5CGJA

Crystal structure of murine keap1 in complex with ra839, a non-covalent small-molecule binder to keap1 and selective activator of nrf2 signalling.
Total Genus 61

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
61
sequence length
290
structure length
290
Chain Sequence
VGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Protein binding
source organism Mus musculus
publication title Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling.
pubmed doi rcsb
molecule keywords Kelch-like ECH-associated protein 1
total genus 61
structure length 290
sequence length 290
ec nomenclature
pdb deposition date 2015-07-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 5cgjA00
3WDZA 2FLUX 5FNQA 5F72C 1X2JA 4IN4A 2Z32A 4ASCA 3WN7A 5FNRA 4L7CA 3ZGCA 4XMBA 5CGJA 2ZW9A 2DYHA 2WOZA 3VNHA 4L7BA 4IQKA 4ZY3A 2XN4A 3ZGDA 3VNGA 1X2RA 4L7DA 1ZGKA 4N1BA 2ZWAA 5FNTA 5FZNA 5FNSA 5FNUA 4ZGCA 3ADEA 4YY8A 1U6DX 4IFJA 3II7A 2ZZKA 4IFLX 5FZJA 4CH9A 2VPJA 4IFNX 4CHBA
chains in the Genus database with same CATH superfamily
4XJ9A 2GHSA 1NCDN 4HZVA 4IN4A 7NN9A 1MR5A 3HRPA 4ASCA 1H6LA 4NC5A 2IARA 2HU4A 2P4OA 3K38A 5H47A 2ZB5A 5GX1A 4GZSA 4A0PA 1NMAN 4YZ1A 1IUCA 1NN2A 4O5TA 3K36A 4N1BA 5FNTA 4M3MA 1E8UA 2YA5A 1INHA 4ZGCA 3S8VA 2VK5A 2W38A 1EUUA 4B7QA 1WCQA 3V64C 4CH9A 5EX7A 5EO8A 4GJTA 4QN4A 4GDIA 2JKBA 4KS4A 4MWYA 4AGIA 4AHAA 1NCCN 4M4UA 2HTYA 4XMBA 1IJQA 4HW6A 4K1JA 2F28A 1V2IA 1NNBA 2ZB6A 4B7NA 1MS3A 4GNAA 2HT8A 3TI3A 1U6DX 5HX0A 5D9BA 3AMRA 1MS4A 1V3DA 3Q6TA 3TI6A 2QWIA 4MWQA 2VVZA 2IAVA 5HUMA 3H72A 3LI3A 4NN9A 3W09A 4C1YB 4XJQA 1W1XA 2X9MA 2F0ZA 4X6KA 4J9TA 1W21A 3K3AA 2XZJA 5B2CA 2F25A 3Q6PA 1PJXA 4L7DA 4QN5A 2F10A 4HZWA 3TI4A 1W20A 2BF6A 2VK7A 1INWA 1L7GA 1POOA 5GX2A 2BZDA 4Q6KA 4XJWA 3CYEA 4FPKA 2IAXA 1W8OA 1V0EA 5FNRA 4HHOA 2IASA 3E5ZA 2AGSA 5FWWA 1EUTA 3GVKA 5EO7A 4HIZA 1CQ1A 4MWXA 4MZAA 3S8ZA 4HZZA 3T1EA 1L7FA 1N6EA 2IVZA 5D9CA 1IVBA 2VW0A 4QN6A 1SNTA 2QWHA 3WW9A 2F12A 1ZI0A 2HTWA 2BATA 2GVXA 4GZXA 3GVLA 1N6DA 2IATA 3A72A 1XOGA 2VWDA 1NSDA 5CGJA 5M1ZA 1K32A 4FOWA 4ZY3A 4CPNA 4XE9A 1N1SA 4FPLA 4FPYA 4SLIA 3V65B 1MS9A 1F8EA 3D12A 2VW1A 2QWDA 2VK6A 4XHXA 1V0FA 3NSSA 4MWJA 4FPCA 1MS5A 4XJUA 3WDZA 1F8CA 1A14N 4MC7A 4IMBA 3SOVA 4KS1A 2GVVA 2SIMA 3BEQA 4K1KA 1IVEA 4JMLA 2HU0A 3O4PA 1MZ5A 1B9SA 1IVCA 1Z4WA 4GZQA 1E8TA 4H53A 4FP3A 5FNUA 4MJUA 4WEFA 5JYYA 5F9TA 2IAPA 4GZWA 1MWEA 3B69A 4CSDA 1MS0A 2IAQA 2B8HA 4CPOA 2FHRA 3BYCA 4B7MA 4QN7A 1INGA 2F27A 5F72C 4FPGA 3V1SA 2F29A 1INXA 1A4GA 3ALXA 4FOYA 1KITA 2SILA 1S18A 1E1AA 2GVUA 2XN4A 1NCBN 4D52A 4DG6A 4UF7A 1Q7FA 3L6VA 2ZWAA 1S0JA 3H6JA 5FZNA 2FPCA 1L7HA 1SLIA 1USXA 4CPLA 1N7DA 1NMBN 1IVDA 3WN7A 3H73A 3DR2A 1WCSA 3O9JA 4MWUA 4X47A 1W0OA 2ZW9A 2VSMA 4HZYA 4QNPA 2OJHA 2DSOA 1NPEA 2F26A 1MS8A 4GN7A 1IUBA 2VAQA 1W0PA 1SO7A 2YA8A 4YZ5A 1Z50A 3FW0A 4IYGA 1CVMA 2FPBA 2VPJA 4MJVA 1W8NA 2YA6A 4MX0A 4FZHA 4GZPA 2HTVA 4XMIA 3KGGA 1NMCA 2FP9A 4XJZA 5HUGA 1F8DA 1XOEA 4X49A 4L7BA 4GZOA 4WEGA 4XJRA 4WA3A 2H2UA 3JU4A 2XCYA 4GN9A 2YDPA 3ADEA 4YY8A 1N1TA 2DG0A 1N6FA 3CL0A 4QN3A 1BJIA 2QWGA 4C1YA 2G8SA 2XZKA 2CMLA 2HTUA 2C4LA 4L7CA 2F24A 5GX4A 4DGRA 3LI5A 3VNHA 4IQKA 4MZEA 3TIBA 1EURA 2VW2A 3I1CA 2HTRA 3FVZA 4H52A 4YZ3A 2AEPA 4IFLX 2QWEA 5FZJA 3SILA 2ISMA 1CRZA 5HUNA 1USRA 2FLUX 3P5BL 2SLIA 2W5NA 4I00A 2Z32A 3TICA 1NCAN 3SOQA 1SUUA 1Z4YA 2QE8A 3TC9A 3PJQA 3ZGDA 3TI8A 1A4QA 4ZLRA 4FP2A 4G3NA 1NSCA 3LI4A 4GNCA 3O9KA 1INYA 4K1HA 5D9DA 4CHBA 3G4HA 4O5SA 4GB1A 2IAWA 3SLIA 3A71A 3NO0A 1F8BA 1INFA 2H2NA 1Z4XA 3ZGCA 3DASA 4MWVA 4FOVA 5HUKA 4FVKA 3CL2A 1V3EA 3OPZA 5GTQA 4WA4A 4FPEA 3VNGA 3SOBB 1V3BA 2GVWA 4XMAA 2A75A 1C5KA 3B7EA 3HLIA 1Z4ZA 2HT7A 2RKCA 2W8BB 3SALA 2XZIA 4XJAA 1OFZA 1X2JA 5B2DA 1NSBA 4FPJA 1RWIA 4MWRA 4MWWA 4PWZA 3D11A 4YW2A 4JF7A 5NN9A 3KYAA 4XILA 2QWCA 2DYHA 4BBWA 4YZ4A 4B7JA 4B7RA 4FPHA 4KS2A 4FJ6A 3IAXA 1V0ZA 2W20A 1DIMA 2IAOA 3S94A 1V04A 2YDTA 4YW3A 2W5OA 4M4VA 3SREA 1IVFA 4IFNX 4CPMA 2FP8A 3K37A 4WA5A 1N1VA 1RWLA 2HT5A 4AH4A 2V91A 4D4UA 1DILA 2YA4A 2WOZA 5GX5A 3ALWA 2W8BA 4XIOA 6NN9A 1B9TA 2QWFA 3G4EA 1NNCA 1ZGKA 5GX3A 4YW4A 2QWKA 4KS5A 2YA7A 4K3YA 3GVJA 3NN9A 4Q1UA 3SANA 4MWLA 3A9HA 1S0IA 1QBIA 4FPOB 3TI5A 4XYXA 4X4AA 2BERA 3Q6KA 4KS3A 1N1YA 4CPYA 2VSKA 1INVA 2C4AA 4NCSA 1QLGA 3TIAA 4UOUA 2POOA 2QWBA 1VCJA 1C9UA 1MS1A 4XIKA 1X2RA 4R40A 4HZXA 2F11A 4D52C 4HHQA 4FQ4A 3S2KA 3K39A 1IVGA 1S1DA 4GNBA 4D8SA 4GZTA 3II7A 4GEZA 4FPFA 4YW5A 4CPZA 1VCUA 4GDJA 4M4NA 1CRUA 3H71A 5FNQA 4YZ2A 1SLLA 3CKZA 4FOQA 1V3CA 4K1IA 4YW1A 3A9GA 3HLHA 2AEQA 2HQSA 4GN8A 2QWJA 4XJ8A 1EUSA 3INBA 1NNAA 3SRGA 3WWAA 2DG1A 1WP5A 3U0SA 1E8VA 2IAUA 1B9VA 1MZ6A 3AMSA 3UC1A 2HTQA 5FNSA 1Z4VA 4AGTA 4XOGA 4IFJA 4D52B 2ZZKA 4XHBA 2QWAA 2AH2A 2F13A
chains in the Genus database with same CATH topology
3WDZA 2FLUX 5FNQA 5F72C 1X2JA 4IN4A 2Z32A 4ASCA 3WN7A 5FNRA 4L7CA 3ZGCA 4XMBA 5CGJA 2ZW9A 2DYHA 2WOZA 3VNHA 4L7BA 4IQKA 4ZY3A 2XN4A 3ZGDA 3VNGA 1X2RA 4L7DA 1ZGKA 4N1BA 2ZWAA 5FNTA 5FZNA 5FNSA 5FNUA 4ZGCA 3ADEA 4YY8A 1U6DX 4IFJA 3II7A 2ZZKA 4IFLX 5FZJA 4CH9A 2VPJA 4IFNX 4CHBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3WDZ A;  2FLU X;  5FNQ A;  5F72 C;  1X2J A;  4IN4 A;  2Z32 A;  4ASC A;  3WN7 A;  5FNR A;  4L7C A;  3ZGC A;  4XMB A;  5CGJ A;  2ZW9 A;  2DYH A;  2WOZ A;  3VNH A;  4L7B A;  4IQK A;  4ZY3 A;  2XN4 A;  3ZGD A;  3VNG A;  1X2R A;  4L7D A;  1ZGK A;  4N1B A;  2ZWA A;  5FNT A;  5FZN A;  5FNS A;  5FNU A;  4ZGC A;  3ADE A;  4YY8 A;  1U6D X;  4IFJ A;  3II7 A;  2ZZK A;  4IFL X;  5FZJ A;  4CH9 A;  2VPJ A;  4IFN X;  4CHB A; 
#chains in the Genus database with same CATH topology
 4XJ9 A;  2GHS A;  1NCD N;  4HZV A;  4IN4 A;  7NN9 A;  1MR5 A;  3HRP A;  4ASC A;  1H6L A;  4NC5 A;  2IAR A;  2HU4 A;  2P4O A;  3K38 A;  5H47 A;  2ZB5 A;  5GX1 A;  4GZS A;  4A0P A;  1NMA N;  4YZ1 A;  1IUC A;  1NN2 A;  4O5T A;  3K36 A;  4N1B A;  5FNT A;  4M3M A;  1E8U A;  2YA5 A;  1INH A;  4ZGC A;  3S8V A;  2VK5 A;  2W38 A;  1EUU A;  4B7Q A;  1WCQ A;  3V64 C;  4CH9 A;  5EX7 A;  5EO8 A;  4GJT A;  4QN4 A;  4GDI A;  2JKB A;  4KS4 A;  4MWY A;  4AGI A;  4AHA A;  1NCC N;  4M4U A;  2HTY A;  4XMB A;  1IJQ A;  4HW6 A;  4K1J A;  2F28 A;  1V2I A;  1NNB A;  2ZB6 A;  4B7N A;  1MS3 A;  4GNA A;  2HT8 A;  3TI3 A;  1U6D X;  5HX0 A;  5D9B A;  3AMR A;  1MS4 A;  1V3D A;  3Q6T A;  3TI6 A;  2QWI A;  4MWQ A;  2VVZ A;  2IAV A;  5HUM A;  3H72 A;  3LI3 A;  4NN9 A;  3W09 A;  4C1Y B;  4XJQ A;  1W1X A;  2X9M A;  2F0Z A;  4X6K A;  4J9T A;  1W21 A;  3K3A A;  2XZJ A;  5B2C A;  2F25 A;  3Q6P A;  1PJX A;  4L7D A;  4QN5 A;  2F10 A;  4HZW A;  3TI4 A;  1W20 A;  2BF6 A;  2VK7 A;  1INW A;  1L7G A;  1POO A;  5GX2 A;  2BZD A;  4Q6K A;  4XJW A;  3CYE A;  4FPK A;  2IAX A;  1W8O A;  1V0E A;  5FNR A;  4HHO A;  2IAS A;  3E5Z A;  2AGS A;  5FWW A;  1EUT A;  3GVK A;  5EO7 A;  4HIZ A;  1CQ1 A;  4MWX A;  4MZA A;  3S8Z A;  4HZZ A;  3T1E A;  1L7F A;  1N6E A;  2IVZ A;  5D9C A;  1IVB A;  2VW0 A;  4QN6 A;  1SNT A;  2QWH A;  3WW9 A;  2F12 A;  1ZI0 A;  2HTW A;  2BAT A;  2GVX A;  4GZX A;  3GVL A;  1N6D A;  2IAT A;  3A72 A;  1XOG A;  2VWD A;  1NSD A;  5CGJ A;  5M1Z A;  1K32 A;  4FOW A;  4ZY3 A;  4CPN A;  4XE9 A;  1N1S A;  4FPL A;  4FPY A;  4SLI A;  3V65 B;  1MS9 A;  1F8E A;  3D12 A;  2VW1 A;  2QWD A;  2VK6 A;  4XHX A;  1V0F A;  3NSS A;  4MWJ A;  4FPC A;  1MS5 A;  4XJU A;  3WDZ A;  1F8C A;  1A14 N;  4MC7 A;  4IMB A;  3SOV A;  4KS1 A;  2GVV A;  2SIM A;  3BEQ A;  4K1K A;  1IVE A;  4JML A;  2HU0 A;  3O4P A;  1MZ5 A;  1B9S A;  1IVC A;  1Z4W A;  4GZQ A;  1E8T A;  4H53 A;  4FP3 A;  5FNU A;  4MJU A;  4WEF A;  5JYY A;  5F9T A;  2IAP A;  4GZW A;  1MWE A;  3B69 A;  4CSD A;  1MS0 A;  2IAQ A;  2B8H A;  4CPO A;  2FHR A;  3BYC A;  4B7M A;  4QN7 A;  1ING A;  2F27 A;  5F72 C;  4FPG A;  3V1S A;  2F29 A;  1INX A;  1A4G A;  3ALX A;  4FOY A;  1KIT A;  2SIL A;  1S18 A;  1E1A A;  2GVU A;  2XN4 A;  1NCB N;  4D52 A;  4DG6 A;  4UF7 A;  1Q7F A;  3L6V A;  2ZWA A;  1S0J A;  3H6J A;  5FZN A;  2FPC A;  1L7H A;  1SLI A;  1USX A;  4CPL A;  1N7D A;  1NMB N;  1IVD A;  3WN7 A;  3H73 A;  3DR2 A;  1WCS A;  3O9J A;  4MWU A;  4X47 A;  1W0O A;  2ZW9 A;  2VSM A;  4HZY A;  4QNP A;  2OJH A;  2DSO A;  1NPE A;  2F26 A;  1MS8 A;  4GN7 A;  1IUB A;  2VAQ A;  1W0P A;  1SO7 A;  2YA8 A;  4YZ5 A;  1Z50 A;  3FW0 A;  4IYG A;  1CVM A;  2FPB A;  2VPJ A;  4MJV A;  1W8N A;  2YA6 A;  4MX0 A;  4FZH A;  4GZP A;  2HTV A;  4XMI A;  3KGG A;  1NMC A;  2FP9 A;  4XJZ A;  5HUG A;  1F8D A;  1XOE A;  4X49 A;  4L7B A;  4GZO A;  4WEG A;  4XJR A;  4WA3 A;  2H2U A;  3JU4 A;  2XCY A;  4GN9 A;  2YDP A;  3ADE A;  4YY8 A;  1N1T A;  2DG0 A;  1N6F A;  3CL0 A;  4QN3 A;  1BJI A;  2QWG A;  4C1Y A;  2G8S A;  2XZK A;  2CML A;  2HTU A;  2C4L A;  4L7C A;  2F24 A;  5GX4 A;  4DGR A;  3LI5 A;  3VNH A;  4IQK A;  4MZE A;  3TIB A;  1EUR A;  2VW2 A;  3I1C A;  2HTR A;  3FVZ A;  4H52 A;  4YZ3 A;  2AEP A;  4IFL X;  2QWE A;  5FZJ A;  3SIL A;  2ISM A;  1CRZ A;  5HUN A;  1USR A;  2FLU X;  3P5B L;  2SLI A;  2W5N A;  4I00 A;  2Z32 A;  3TIC A;  1NCA N;  3SOQ A;  1SUU A;  1Z4Y A;  2QE8 A;  3TC9 A;  3PJQ A;  3ZGD A;  3TI8 A;  1A4Q A;  4ZLR A;  4FP2 A;  4G3N A;  1NSC A;  3LI4 A;  4GNC A;  3O9K A;  1INY A;  4K1H A;  5D9D A;  4CHB A;  3G4H A;  4O5S A;  4GB1 A;  2IAW A;  3SLI A;  3A71 A;  3NO0 A;  1F8B A;  1INF A;  2H2N A;  1Z4X A;  3ZGC A;  3DAS A;  4MWV A;  4FOV A;  5HUK A;  4FVK A;  3CL2 A;  1V3E A;  3OPZ A;  5GTQ A;  4WA4 A;  4FPE A;  3VNG A;  3SOB B;  1V3B A;  2GVW A;  4XMA A;  2A75 A;  1C5K A;  3B7E A;  3HLI A;  1Z4Z A;  2HT7 A;  2RKC A;  2W8B B;  3SAL A;  2XZI A;  4XJA A;  1OFZ A;  1X2J A;  5B2D A;  1NSB A;  4FPJ A;  1RWI A;  4MWR A;  4MWW A;  4PWZ A;  3D11 A;  4YW2 A;  4JF7 A;  5NN9 A;  3KYA A;  4XIL A;  2QWC A;  2DYH A;  4BBW A;  4YZ4 A;  4B7J A;  4B7R A;  4FPH A;  4KS2 A;  4FJ6 A;  3IAX A;  1V0Z A;  2W20 A;  1DIM A;  2IAO A;  3S94 A;  1V04 A;  2YDT A;  4YW3 A;  2W5O A;  4M4V A;  3SRE A;  1IVF A;  4IFN X;  4CPM A;  2FP8 A;  3K37 A;  4WA5 A;  1N1V A;  1RWL A;  2HT5 A;  4AH4 A;  2V91 A;  4D4U A;  1DIL A;  2YA4 A;  2WOZ A;  5GX5 A;  3ALW A;  2W8B A;  4XIO A;  6NN9 A;  1B9T A;  2QWF A;  3G4E A;  1NNC A;  1ZGK A;  5GX3 A;  4YW4 A;  2QWK A;  4KS5 A;  2YA7 A;  4K3Y A;  3GVJ A;  3NN9 A;  4Q1U A;  3SAN A;  4MWL A;  3A9H A;  1S0I A;  1QBI A;  4FPO B;  3TI5 A;  4XYX A;  4X4A A;  2BER A;  3Q6K A;  4KS3 A;  1N1Y A;  4CPY A;  2VSK A;  1INV A;  2C4A A;  4NCS A;  1QLG A;  3TIA A;  4UOU A;  2POO A;  2QWB A;  1VCJ A;  1C9U A;  1MS1 A;  4XIK A;  1X2R A;  4R40 A;  4HZX A;  2F11 A;  4D52 C;  4HHQ A;  4FQ4 A;  3S2K A;  3K39 A;  1IVG A;  1S1D A;  4GNB A;  4D8S A;  4GZT A;  3II7 A;  4GEZ A;  4FPF A;  4YW5 A;  4CPZ A;  1VCU A;  4GDJ A;  4M4N A;  1CRU A;  3H71 A;  5FNQ A;  4YZ2 A;  1SLL A;  3CKZ A;  4FOQ A;  1V3C A;  4K1I A;  4YW1 A;  3A9G A;  3HLH A;  2AEQ A;  2HQS A;  4GN8 A;  2QWJ A;  4XJ8 A;  1EUS A;  3INB A;  1NNA A;  3SRG A;  3WWA A;  2DG1 A;  1WP5 A;  3U0S A;  1E8V A;  2IAU A;  1B9V A;  1MZ6 A;  3AMS A;  3UC1 A;  2HTQ A;  5FNS A;  1Z4V A;  4AGT A;  4XOG A;  4IFJ A;  4D52 B;  2ZZK A;  4XHB A;  2QWA A;  2AH2 A;  2F13 A; 
#chains in the Genus database with same CATH homology
 3WDZ A;  2FLU X;  5FNQ A;  5F72 C;  1X2J A;  4IN4 A;  2Z32 A;  4ASC A;  3WN7 A;  5FNR A;  4L7C A;  3ZGC A;  4XMB A;  5CGJ A;  2ZW9 A;  2DYH A;  2WOZ A;  3VNH A;  4L7B A;  4IQK A;  4ZY3 A;  2XN4 A;  3ZGD A;  3VNG A;  1X2R A;  4L7D A;  1ZGK A;  4N1B A;  2ZWA A;  5FNT A;  5FZN A;  5FNS A;  5FNU A;  4ZGC A;  3ADE A;  4YY8 A;  1U6D X;  4IFJ A;  3II7 A;  2ZZK A;  4IFL X;  5FZJ A;  4CH9 A;  2VPJ A;  4IFN X;  4CHB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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