5F72C

De novo design and crystallographic validation of antibodies targeting a pre-selected epitope
Total Genus 62
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
62
sequence length
285
structure length
285
Chain Sequence
GRLIYTAGGYFRQSLSYLEAYNPSDGTWLDLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVT
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags De novo protein
source organism Homo sapiens
publication title De novo design and crystallographic validation of antibodies targeting a pre-selected epitope
rcsb
molecule keywords Kelch-like ECH-associated protein 1
total genus 62
structure length 285
sequence length 285
chains with identical sequence K
ec nomenclature
pdb deposition date 2015-12-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 5f72C00
5FNQA 5FNSA 3ZGCA 1ZGKA 2FLUX 5FNRA 4IFJA 3II7A 2WOZA 2Z32A 4L7DA 4IFLX 2ZW9A 2ZZKA 4ZY3A 4N1BA 2ZWAA 3ZGDA 5FNTA 4L7BA 4IN4A 4XMBA 3VNHA 1X2JA 4CH9A 4IFNX 3WDZA 1X2RA 4L7CA 2XN4A 5FZJA 5CGJA 3WN7A 2VPJA 3ADEA 3VNGA 4ASCA 5FZNA 5FNUA 4ZGCA 1U6DX 4CHBA 4YY8A 5F72C 2DYHA 4IQKA
chains in the Genus database with same CATH superfamily
3ZGCA 3OPZA 4HIZA 1IUBA 1CRUA 5GX4A 3HLHA 2AGSA 2YA5A 4NN9A 1XOEA 4AHAA 4JMLA 3TI5A 3E5ZA 3A9HA 4GZWA 3G4HA 4KS4A 2YA6A 1MWEA 4C1YA 5FZJA 5B2CA 2HQSA 2QWJA 2QWEA 4GN9A 1NCCN 4X47A 1K32A 4M4NA 5H47A 5B2DA 5EX7A 2BF6A 4FOQA 2DYHA 3ZGDA 1E8TA 4IQKA 5FNSA 5JYYA 1ZI0A 4YZ3A 2QE8A 1H6LA 2QWCA 1SNTA 3CL2A 4M4VA 4N1BA 3V1SA 3S94A 5D9BA 3NN9A 2VAQA 3JU4A 1Q7FA 2IAWA 4IFNX 1W1XA 4XILA 4FOVA 4GZTA 2FPBA 2ISMA 4MZEA 2HTVA 2FP8A 4ZGCA 2QWHA 1N6DA 1N6FA 2H2UA 1Z4XA 1Z4ZA 4YW4A 4Q6KA 2FPCA 4K1JA 3L6VA 4DG6A 1L7FA 2W5NA 1MS4A 4FPEA 1SUUA 4B7RA 3V64C 3Q6TA 1OFZA 4FP3A 4FQ4A 1IUCA 1X2RA 4Q1UA 4XJ9A 2YA4A 4CPMA 5CGJA 1CVMA 4G3NA 1Z50A 2F13A 7NN9A 5FWWA 3FW0A 1E1AA 4XHBA 2IAQA 4MX0A 4WA5A 4NCSA 1MS8A 4D52B 2F29A 2F25A 5FNQA 5FNRA 1Z4WA 2HTWA 2DG1A 4M4UA 4XJUA 3HLIA 1Z4VA 3K39A 4X6KA 4HZVA 2GVXA 4IMBA 2HU4A 4A0PA 4SLIA 1V3EA 4HZXA 2IATA 1MZ5A 1CRZA 3DR2A 6NN9A 1MZ6A 2GHSA 2XN4A 1C5KA 4X49A 4MWJA 1MS5A 4NC5A 4X4AA 3O9KA 5FZNA 1CQ1A 1B9SA 3UC1A 4FPCA 4D52A 3KGGA 3SREA 3LI4A 1V0FA 1W8OA 3II7A 4FZHA 3S8VA 1N1SA 3S8ZA 1MS9A 2C4LA 3GVLA 4HZYA 1INVA 3G4EA 2AH2A 4DGRA 1SO7A 2YDTA 4ASCA 5FNUA 4XHXA 3FVZA 2QWGA 2F11A 4FPKA 4MWYA 2VK5A 4O5TA 1L7GA 3ALWA 4UOUA 4GB1A 4MWUA 1NNAA 1KITA 3SLIA 4WA3A 2IAVA 4L7BA 1V0EA 4I00A 4FOYA 1A4GA 4PWZA 4YZ1A 1E8UA 3A72A 3D12A 3WW9A 1BJIA 2QWFA 4QN5A 2YA7A 4MWXA 4FPOB 1L7HA 3HRPA 4K1IA 2HT7A 2F28A 2ZB6A 1NCBN 1V3CA 1INYA 2VVZA 4YY8A 3H6JA 4D52C 2WOZA 4L7DA 1MS1A 3K36A 1A4QA 3K3AA 4XJQA 3SALA 1Z4YA 4B7NA 1F8DA 3O9JA 1W0OA 1IVBA 4FPYA 2IAXA 4L7CA 1POOA 1IVGA 1USXA 2VPJA 3TI6A 4QNPA 4GN8A 3A9GA 2IAUA 3NO0A 1RWIA 4GN7A 4XE9A 2V91A 2FP9A 4FPGA 4CPLA 4R40A 4YW5A 5GX3A 3DASA 4KS2A 4GZOA 2VSKA 3BEQA 4CSDA 2JKBA 3TC9A 4XJWA 5GX2A 1EURA 4XJ8A 2SILA 2B8HA 4GZPA 3VNHA 4IYGA 3INBA 2CMLA 3TI8A 4FOWA 4GDJA 4WEFA 5M1ZA 1WCQA 3KYAA 1W20A 2RKCA 3PJQA 5HUGA 2VW0A 3S2KA 2W20A 4CPNA 1W0PA 4H52A 3SILA 1INFA 3GVKA 1S18A 2IVZA 2BATA 2W38A 4HZWA 2QWBA 3I1CA 2VSMA 1INGA 4FP2A 4XOGA 3SRGA 2Z32A 1EUSA 4YZ5A 2ZZKA 1V04A 2ZWAA 4B7QA 1DILA 5GX5A 4BBWA 2FHRA 1QLGA 4MC7A 4MZAA 3TICA 4O5SA 3B7EA 3K37A 1W21A 4K3YA 4XJAA 4FPFA 1WCSA 4QN3A 2HU0A 4YW3A 1NMAN 2GVVA 4YW1A 4CHBA 2F0ZA 2QWDA 1NSCA 3A71A 4JF7A 4QN4A 2HTQA 4FPLA 4CPOA 3Q6PA 1NCAN 1IVCA 5HX0A 1V3BA 4CPZA 1W8NA 3GVJA 1PJXA 4QN7A 2P4OA 1NNCA 1IJQA 3P5BL 4XYXA 3NSSA 3AMSA 5D9CA 2XZKA 1QBIA 2A75A 3O4PA 2YDPA 1MS3A 2YA8A 5GTQA 1SLLA 2GVUA 2POOA 2VK6A 3W09A 1VCUA 1NSDA 2HT8A 4QN6A 2XCYA 2ZW9A 4FPHA 4J9TA 4KS1A 1RWLA 3WDZA 2IARA 3SOQA 1B9VA 4XMAA 5D9DA 3ADEA 1NNBA 3CYEA 2IASA 5NN9A 2SIMA 1NMBN 4CPYA 2C4AA 2QWKA 1NN2A 4HZZA 3H72A 1F8EA 1F8BA 1V3DA 4IFJA 1USRA 4XJRA 1S0IA 4XIKA 4AGIA 4FJ6A 1DIMA 2W8BA 4IN4A 2OJHA 4XMBA 1INWA 2AEPA 3V65B 5EO7A 2F10A 2BERA 3K38A 1IVDA 3SOBB 2VW1A 3VNGA 4GNBA 5GX1A 1IVFA 3SANA 3AMRA 4K1HA 2QWAA 3WWAA 1S0JA 3CL0A 1N1VA 1N1YA 3CKZA 2G8SA 2GVWA 4D4UA 4GNAA 1E8VA 3ALXA 1IVEA 2DSOA 2F26A 1EUTA 2IAPA 4YZ4A 4MWRA 2F24A 1B9TA 2FLUX 3Q6KA 4XIOA 4GJTA 3SOVA 4AGTA 5HUNA 2IAOA 4ZY3A 1NCDN 1A14N 1NSBA 3H71A 4GZQA 3LI5A 4K1KA 4CH9A 4H53A 4MWQA 2SLIA 4GZXA 3LI3A 5HUKA 4GDIA 3D11A 1VCJA 4GEZA 3B69A 1N6EA 5F72C 4AH4A 1XOGA 4HW6A 4KS5A 1INHA 4MWLA 4FPJA 3TI4A 1SLIA 4B7MA 4YW2A 1S1DA 4M3MA 4KS3A 5FNTA 3U0SA 4HHQA 2HTRA 1X2JA 4FVKA 3TIAA 2X9MA 3WN7A 2AEQA 3TIBA 2DG0A 1U6DX 2W5OA 5HUMA 3BYCA 1F8CA 4D8SA 4WA4A 4UF7A 2VWDA 1ZGKA 4GZSA 1NMCA 2VW2A 4MWWA 4IFLX 1EUUA 2H2NA 1MR5A 2HTYA 3IAXA 4HHOA 5EO8A 1NPEA 5F9TA 1V2IA 4WEGA 4MWVA 1N1TA 2W8BB 2ZB5A 2QWIA 2XZJA 2HTUA 2F12A 1N7DA 4C1YB 2XZIA 4XMIA 4XJZA 1V0ZA 1INXA 4GNCA 4ZLRA 1C9UA 2HT5A 4MJUA 4B7JA 4YZ2A 1MS0A 3TI3A 3H73A 3T1EA 2VK7A 2BZDA 1WP5A 2F27A 4MJVA
chains in the Genus database with same CATH topology
5FNQA 5FNSA 3ZGCA 1ZGKA 2FLUX 5FNRA 4IFJA 3II7A 2WOZA 2Z32A 4L7DA 4IFLX 2ZW9A 2ZZKA 4ZY3A 4N1BA 2ZWAA 3ZGDA 5FNTA 4L7BA 4IN4A 4XMBA 3VNHA 1X2JA 4CH9A 4IFNX 3WDZA 1X2RA 4L7CA 2XN4A 5FZJA 5CGJA 3WN7A 2VPJA 3ADEA 3VNGA 4ASCA 5FZNA 5FNUA 4ZGCA 1U6DX 4CHBA 4YY8A 5F72C 2DYHA 4IQKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5FNQ A;  5FNS A;  3ZGC A;  1ZGK A;  2FLU X;  5FNR A;  4IFJ A;  3II7 A;  2WOZ A;  2Z32 A;  4L7D A;  4IFL X;  2ZW9 A;  2ZZK A;  4ZY3 A;  4N1B A;  2ZWA A;  3ZGD A;  5FNT A;  4L7B A;  4IN4 A;  4XMB A;  3VNH A;  1X2J A;  4CH9 A;  4IFN X;  3WDZ A;  1X2R A;  4L7C A;  2XN4 A;  5FZJ A;  5CGJ A;  3WN7 A;  2VPJ A;  3ADE A;  3VNG A;  4ASC A;  5FZN A;  5FNU A;  4ZGC A;  1U6D X;  4CHB A;  4YY8 A;  5F72 C;  2DYH A;  4IQK A; 
#chains in the Genus database with same CATH topology
 3ZGC A;  3OPZ A;  4HIZ A;  1IUB A;  1CRU A;  5GX4 A;  3HLH A;  2AGS A;  2YA5 A;  4NN9 A;  1XOE A;  4AHA A;  4JML A;  3TI5 A;  3E5Z A;  3A9H A;  4GZW A;  3G4H A;  4KS4 A;  2YA6 A;  1MWE A;  4C1Y A;  5FZJ A;  5B2C A;  2HQS A;  2QWJ A;  2QWE A;  4GN9 A;  1NCC N;  4X47 A;  1K32 A;  4M4N A;  5H47 A;  5B2D A;  5EX7 A;  2BF6 A;  4FOQ A;  2DYH A;  3ZGD A;  1E8T A;  4IQK A;  5FNS A;  5JYY A;  1ZI0 A;  4YZ3 A;  2QE8 A;  1H6L A;  2QWC A;  1SNT A;  3CL2 A;  4M4V A;  4N1B A;  3V1S A;  3S94 A;  5D9B A;  3NN9 A;  2VAQ A;  3JU4 A;  1Q7F A;  2IAW A;  4IFN X;  1W1X A;  4XIL A;  4FOV A;  4GZT A;  2FPB A;  2ISM A;  4MZE A;  2HTV A;  2FP8 A;  4ZGC A;  2QWH A;  1N6D A;  1N6F A;  2H2U A;  1Z4X A;  1Z4Z A;  4YW4 A;  4Q6K A;  2FPC A;  4K1J A;  3L6V A;  4DG6 A;  1L7F A;  2W5N A;  1MS4 A;  4FPE A;  1SUU A;  4B7R A;  3V64 C;  3Q6T A;  1OFZ A;  4FP3 A;  4FQ4 A;  1IUC A;  1X2R A;  4Q1U A;  4XJ9 A;  2YA4 A;  4CPM A;  5CGJ A;  1CVM A;  4G3N A;  1Z50 A;  2F13 A;  7NN9 A;  5FWW A;  3FW0 A;  1E1A A;  4XHB A;  2IAQ A;  4MX0 A;  4WA5 A;  4NCS A;  1MS8 A;  4D52 B;  2F29 A;  2F25 A;  5FNQ A;  5FNR A;  1Z4W A;  2HTW A;  2DG1 A;  4M4U A;  4XJU A;  3HLI A;  1Z4V A;  3K39 A;  4X6K A;  4HZV A;  2GVX A;  4IMB A;  2HU4 A;  4A0P A;  4SLI A;  1V3E A;  4HZX A;  2IAT A;  1MZ5 A;  1CRZ A;  3DR2 A;  6NN9 A;  1MZ6 A;  2GHS A;  2XN4 A;  1C5K A;  4X49 A;  4MWJ A;  1MS5 A;  4NC5 A;  4X4A A;  3O9K A;  5FZN A;  1CQ1 A;  1B9S A;  3UC1 A;  4FPC A;  4D52 A;  3KGG A;  3SRE A;  3LI4 A;  1V0F A;  1W8O A;  3II7 A;  4FZH A;  3S8V A;  1N1S A;  3S8Z A;  1MS9 A;  2C4L A;  3GVL A;  4HZY A;  1INV A;  3G4E A;  2AH2 A;  4DGR A;  1SO7 A;  2YDT A;  4ASC A;  5FNU A;  4XHX A;  3FVZ A;  2QWG A;  2F11 A;  4FPK A;  4MWY A;  2VK5 A;  4O5T A;  1L7G A;  3ALW A;  4UOU A;  4GB1 A;  4MWU A;  1NNA A;  1KIT A;  3SLI A;  4WA3 A;  2IAV A;  4L7B A;  1V0E A;  4I00 A;  4FOY A;  1A4G A;  4PWZ A;  4YZ1 A;  1E8U A;  3A72 A;  3D12 A;  3WW9 A;  1BJI A;  2QWF A;  4QN5 A;  2YA7 A;  4MWX A;  4FPO B;  1L7H A;  3HRP A;  4K1I A;  2HT7 A;  2F28 A;  2ZB6 A;  1NCB N;  1V3C A;  1INY A;  2VVZ A;  4YY8 A;  3H6J A;  4D52 C;  2WOZ A;  4L7D A;  1MS1 A;  3K36 A;  1A4Q A;  3K3A A;  4XJQ A;  3SAL A;  1Z4Y A;  4B7N A;  1F8D A;  3O9J A;  1W0O A;  1IVB A;  4FPY A;  2IAX A;  4L7C A;  1POO A;  1IVG A;  1USX A;  2VPJ A;  3TI6 A;  4QNP A;  4GN8 A;  3A9G A;  2IAU A;  3NO0 A;  1RWI A;  4GN7 A;  4XE9 A;  2V91 A;  2FP9 A;  4FPG A;  4CPL A;  4R40 A;  4YW5 A;  5GX3 A;  3DAS A;  4KS2 A;  4GZO A;  2VSK A;  3BEQ A;  4CSD A;  2JKB A;  3TC9 A;  4XJW A;  5GX2 A;  1EUR A;  4XJ8 A;  2SIL A;  2B8H A;  4GZP A;  3VNH A;  4IYG A;  3INB A;  2CML A;  3TI8 A;  4FOW A;  4GDJ A;  4WEF A;  5M1Z A;  1WCQ A;  3KYA A;  1W20 A;  2RKC A;  3PJQ A;  5HUG A;  2VW0 A;  3S2K A;  2W20 A;  4CPN A;  1W0P A;  4H52 A;  3SIL A;  1INF A;  3GVK A;  1S18 A;  2IVZ A;  2BAT A;  2W38 A;  4HZW A;  2QWB A;  3I1C A;  2VSM A;  1ING A;  4FP2 A;  4XOG A;  3SRG A;  2Z32 A;  1EUS A;  4YZ5 A;  2ZZK A;  1V04 A;  2ZWA A;  4B7Q A;  1DIL A;  5GX5 A;  4BBW A;  2FHR A;  1QLG A;  4MC7 A;  4MZA A;  3TIC A;  4O5S A;  3B7E A;  3K37 A;  1W21 A;  4K3Y A;  4XJA A;  4FPF A;  1WCS A;  4QN3 A;  2HU0 A;  4YW3 A;  1NMA N;  2GVV A;  4YW1 A;  4CHB A;  2F0Z A;  2QWD A;  1NSC A;  3A71 A;  4JF7 A;  4QN4 A;  2HTQ A;  4FPL A;  4CPO A;  3Q6P A;  1NCA N;  1IVC A;  5HX0 A;  1V3B A;  4CPZ A;  1W8N A;  3GVJ A;  1PJX A;  4QN7 A;  2P4O A;  1NNC A;  1IJQ A;  3P5B L;  4XYX A;  3NSS A;  3AMS A;  5D9C A;  2XZK A;  1QBI A;  2A75 A;  3O4P A;  2YDP A;  1MS3 A;  2YA8 A;  5GTQ A;  1SLL A;  2GVU A;  2POO A;  2VK6 A;  3W09 A;  1VCU A;  1NSD A;  2HT8 A;  4QN6 A;  2XCY A;  2ZW9 A;  4FPH A;  4J9T A;  4KS1 A;  1RWL A;  3WDZ A;  2IAR A;  3SOQ A;  1B9V A;  4XMA A;  5D9D A;  3ADE A;  1NNB A;  3CYE A;  2IAS A;  5NN9 A;  2SIM A;  1NMB N;  4CPY A;  2C4A A;  2QWK A;  1NN2 A;  4HZZ A;  3H72 A;  1F8E A;  1F8B A;  1V3D A;  4IFJ A;  1USR A;  4XJR A;  1S0I A;  4XIK A;  4AGI A;  4FJ6 A;  1DIM A;  2W8B A;  4IN4 A;  2OJH A;  4XMB A;  1INW A;  2AEP A;  3V65 B;  5EO7 A;  2F10 A;  2BER A;  3K38 A;  1IVD A;  3SOB B;  2VW1 A;  3VNG A;  4GNB A;  5GX1 A;  1IVF A;  3SAN A;  3AMR A;  4K1H A;  2QWA A;  3WWA A;  1S0J A;  3CL0 A;  1N1V A;  1N1Y A;  3CKZ A;  2G8S A;  2GVW A;  4D4U A;  4GNA A;  1E8V A;  3ALX A;  1IVE A;  2DSO A;  2F26 A;  1EUT A;  2IAP A;  4YZ4 A;  4MWR A;  2F24 A;  1B9T A;  2FLU X;  3Q6K A;  4XIO A;  4GJT A;  3SOV A;  4AGT A;  5HUN A;  2IAO A;  4ZY3 A;  1NCD N;  1A14 N;  1NSB A;  3H71 A;  4GZQ A;  3LI5 A;  4K1K A;  4CH9 A;  4H53 A;  4MWQ A;  2SLI A;  4GZX A;  3LI3 A;  5HUK A;  4GDI A;  3D11 A;  1VCJ A;  4GEZ A;  3B69 A;  1N6E A;  5F72 C;  4AH4 A;  1XOG A;  4HW6 A;  4KS5 A;  1INH A;  4MWL A;  4FPJ A;  3TI4 A;  1SLI A;  4B7M A;  4YW2 A;  1S1D A;  4M3M A;  4KS3 A;  5FNT A;  3U0S A;  4HHQ A;  2HTR A;  1X2J A;  4FVK A;  3TIA A;  2X9M A;  3WN7 A;  2AEQ A;  3TIB A;  2DG0 A;  1U6D X;  2W5O A;  5HUM A;  3BYC A;  1F8C A;  4D8S A;  4WA4 A;  4UF7 A;  2VWD A;  1ZGK A;  4GZS A;  1NMC A;  2VW2 A;  4MWW A;  4IFL X;  1EUU A;  2H2N A;  1MR5 A;  2HTY A;  3IAX A;  4HHO A;  5EO8 A;  1NPE A;  5F9T A;  1V2I A;  4WEG A;  4MWV A;  1N1T A;  2W8B B;  2ZB5 A;  2QWI A;  2XZJ A;  2HTU A;  2F12 A;  1N7D A;  4C1Y B;  2XZI A;  4XMI A;  4XJZ A;  1V0Z A;  1INX A;  4GNC A;  4ZLR A;  1C9U A;  2HT5 A;  4MJU A;  4B7J A;  4YZ2 A;  1MS0 A;  3TI3 A;  3H73 A;  3T1E A;  2VK7 A;  2BZD A;  1WP5 A;  2F27 A;  4MJV A; 
#chains in the Genus database with same CATH homology
 5FNQ A;  5FNS A;  3ZGC A;  1ZGK A;  2FLU X;  5FNR A;  4IFJ A;  3II7 A;  2WOZ A;  2Z32 A;  4L7D A;  4IFL X;  2ZW9 A;  2ZZK A;  4ZY3 A;  4N1B A;  2ZWA A;  3ZGD A;  5FNT A;  4L7B A;  4IN4 A;  4XMB A;  3VNH A;  1X2J A;  4CH9 A;  4IFN X;  3WDZ A;  1X2R A;  4L7C A;  2XN4 A;  5FZJ A;  5CGJ A;  3WN7 A;  2VPJ A;  3ADE A;  3VNG A;  4ASC A;  5FZN A;  5FNU A;  4ZGC A;  1U6D X;  4CHB A;  4YY8 A;  5F72 C;  2DYH A;  4IQK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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