5F72C

De novo design and crystallographic validation of antibodies targeting a pre-selected epitope
Total Genus 62
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
62
sequence length
285
structure length
285
Chain Sequence
GRLIYTAGGYFRQSLSYLEAYNPSDGTWLDLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVT
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title De novo design and crystallographic validation of antibodies targeting a pre-selected epitope
rcsb
molecule keywords Kelch-like ECH-associated protein 1
molecule tags De novo protein
source organism Homo sapiens
total genus 62
structure length 285
sequence length 285
chains with identical sequence K
ec nomenclature
pdb deposition date 2015-12-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 5f72C00
4IQKA 5FZJA 4IN4A 5FNSA 1ZGKA 3ADEA 3WDZA 3WN7A 2XN4A 1X2JA 2ZW9A 4IFLX 5F72C 4CH9A 4YY8A 2DYHA 4N1BA 5FNQA 3VNGA 1X2RA 5FNTA 5FNRA 4XMBA 3II7A 5FNUA 4ZGCA 4L7CA 5CGJA 1U6DX 4L7DA 2WOZA 3VNHA 2ZWAA 3ZGDA 2Z32A 2FLUX 2ZZKA 4ZY3A 4ASCA 4CHBA 5FZNA 4IFNX 3ZGCA 4IFJA 2VPJA 4L7BA
chains in the Genus database with same CATH superfamily
4MWRA 4HZYA 1VCJA 1C5KA 5GTQA 4YY8A 2YA8A 2DYHA 2F13A 1OFZA 2VSKA 4FPKA 1CQ1A 4G3NA 2F28A 3SRGA 1NSCA 3DR2A 3NSSA 2FP9A 2F25A 5EX7A 2W5NA 4BBWA 1W8NA 3V65B 5GX2A 1WCQA 4IFNX 3CL0A 4NC5A 4CPMA 1SLIA 1MS5A 3TI5A 3O9JA 4GZXA 5FNSA 1V3EA 2W5OA 4AGIA 2VK5A 4N1BA 5FNQA 1V3CA 4MX0A 2GVXA 3H73A 4KS1A 4M4VA 4GZPA 4FVKA 2ZB5A 4CPLA 1B9SA 3UC1A 2BF6A 2ZB6A 4X6KA 2QWGA 1IUCA 3H72A 3CL2A 4Q1UA 4ASCA 4FPOB 4GZQA 4D52A 3O9KA 1W0PA 3HRPA 4CPOA 5EO8A 2JKBA 4K3YA 1F8DA 4HIZA 4M4NA 1ZI0A 1X2RA 1EUUA 3FW0A 2QWKA 4D52C 4MZEA 1INYA 2YA5A 4FPCA 1N1SA 2FPBA 3PJQA 4I00A 4HW6A 1W0OA 4M4UA 1XOEA 3GVLA 4FPHA 1USRA 1SUUA 4X47A 3WDZA 1B9TA 2ZW9A 4GEZA 3FVZA 4UOUA 1F8CA 3SREA 2AEPA 2FP8A 1NSDA 1S0JA 1MR5A 2G8SA 1MS0A 4MC7A 2POOA 1KITA 4XIKA 3V1SA 1NMBN 1NCDN 3TC9A 1RWLA 2XCYA 1V0FA 4QN5A 3INBA 3SOVA 4ZY3A 2ZZKA 1V2IA 5GX1A 4GZTA 4L7BA 1WP5A 2YA7A 3B69A 1NCAN 2OJHA 2HQSA 3A9GA 4YZ2A 4XIOA 4XOGA 4SLIA 1A4QA 3U0SA 2GVUA 2QE8A 4GDJA 3HLIA 3S94A 4L7CA 2QWBA 2GVWA 4CPNA 5EO7A 4YW1A 5HX0A 2IAOA 4WA3A 4MWLA 1IVFA 4XE9A 4UF7A 4GZWA 2AH2A 3Q6KA 5NN9A 3ZGCA 2B8HA 1MS8A 2QWIA 4GNBA 5H47A 2P4OA 4FPJA 2QWDA 2SLIA 2YDTA 2H2NA 4MWJA 1Q7FA 4C1YB 2GHSA 1K32A 4M3MA 1INVA 3A9HA 3LI3A 4AHAA 2H2UA 5FNUA 3K39A 1NNCA 2C4LA 1XOGA 4GZOA 2F26A 1N7DA 1VCUA 2FPCA 4CHBA 3TI3A 1N6EA 4ZGCA 1IVCA 1V3BA 4HZXA 4K1HA 5FNRA 1QBIA 4QNPA 1INHA 1INGA 2QWAA 2IAXA 2HT8A 4NCSA 5M1ZA 3GVKA 4KS4A 1F8EA 2IAUA 3G4EA 4DGRA 3D11A 2X9MA 4A0PA 4QN6A 4HHOA 3DASA 4GJTA 5GX5A 1NNBA 1MS3A 2IAQA 2F29A 2VWDA 1C9UA 3KYAA 5F72C 2XZIA 4XJAA 4XJ9A 3TI8A 4FOVA 1USXA 4XJ8A 5B2DA 1W21A 4HZVA 4XJUA 4XJWA 1NSBA 1PJXA 1INWA 4O5SA 4XJZA 1E1AA 3IAXA 2IATA 2W8BB 1NN2A 1DIMA 1MZ5A 1W20A 1IVBA 4FOQA 4Q6KA 4WA5A 1NCCN 1CRZA 4KS3A 1SO7A 1IUBA 4H53A 2FHRA 1N1YA 2YA6A 4X4AA 1EUTA 4GN8A 3S8ZA 1MWEA 1IJQA 2IAWA 4FPFA 4FPGA 1Z4ZA 4L7DA 2HU4A 2AEQA 4QN4A 4YW2A 4XHXA 1EUSA 2FLUX 4GZSA 2VW0A 4YW5A 4XILA 4FZHA 4PWZA 1BJIA 1SNTA 4IQKA 4MWVA 1SLLA 1L7GA 4WEGA 1MS1A 1A14N 3Q6TA 4FP2A 3W09A 4MWWA 4R40A 3P5BL 2DSOA 3SALA 1IVGA 3LI4A 4MWYA 2QWFA 3CYEA 4GN7A 2W20A 3OPZA 1H6LA 1EURA 2VW1A 2F12A 2SIMA 3ZGDA 2F0ZA 2IASA 1NMCA 1E8VA 4D8SA 1E8TA 2WOZA 4FQ4A 5D9BA 4AGTA 4D52B 1N1TA 4FPEA 4XMAA 7NN9A 2YDPA 5HUNA 5GX4A 3K3AA 3GVJA 4B7QA 3E5ZA 3ALXA 4CSDA 2QWHA 3SLIA 4CPZA 4FPYA 4IMBA 4B7NA 2RKCA 1W8OA 2DG1A 3K37A 4MWXA 4MJVA 2W38A 1CVMA 4XYXA 2ZWAA 2VK6A 1V0EA 4D4UA 3TIAA 2BZDA 4XHBA 2Z32A 1Z4XA 3V64C 4IFJA 5FZJA 3CKZA 3ADEA 5FWWA 4DG6A 2HTQA 2XN4A 3K38A 4FP3A 3VNGA 4XJQA 2GVVA 3L6VA 1POOA 3BYCA 6NN9A 2F11A 1N1VA 4FOYA 3I1CA 2QWCA 2HTYA 3K36A 2HTWA 1QLGA 2HT7A 3Q6PA 2BATA 1CRUA 1Z4WA 3SANA 1V04A 1MS9A 4MZAA 5HUGA 1F8BA 4IN4A 3TI4A 3KGGA 4HZZA 3G4HA 3S2KA 5D9CA 1X2JA 1MZ6A 4IFLX 2F24A 2DG0A 4XJRA 4YW3A 4FJ6A 4GB1A 4YW4A 5B2CA 3JU4A 1MS4A 4YZ1A 4GN9A 4AH4A 1S0IA 2IAVA 1Z4YA 2CMLA 1Z4VA 1N6DA 4B7MA 5CGJA 4GNAA 1U6DX 2AGSA 4YZ4A 3NN9A 4FPLA 4YZ5A 4H52A 4QN3A 5FZNA 1V3DA 2C4AA 2XZKA 4XMIA 2HU0A 1V0ZA 1N6FA 2VW2A 1S1DA 4ZLRA 3WN7A 4C1YA 2BERA 2VAQA 1IVEA 1E8UA 5HUMA 4O5TA 4J9TA 1S18A 3NO0A 2HT5A 4KS2A 4MWQA 1NMAN 1NCBN 1Z50A 1INXA 3AMSA 4HZWA 1A4GA 3VNHA 2ISMA 3WWAA 1L7HA 2F27A 3H6JA 2HTUA 1B9VA 5D9DA 1NNAA 3TICA 4QN7A 4IYGA 3TIBA 1INFA 4NN9A 3WW9A 2F10A 1NPEA 4K1IA 4CH9A 3O4PA 3AMRA 1W1XA 4KS5A 4YZ3A 4K1JA 2IAPA 4HHQA 2IVZA 2XZJA 3HLHA 5F9TA 3SOQA 2IARA 3S8VA 4B7RA 2HTRA 2YA4A 2SILA 4MJUA 3SILA 3A72A 4WEFA 4CPYA 4JF7A 4B7JA 4K1KA 3D12A 2VK7A 1ZGKA 2VSMA 3B7EA 4WA4A 4X49A 2QWJA 4GDIA 3TI6A 2HTVA 5GX3A 5HUKA 3LI5A 4JMLA 5FNTA 2VVZA 3T1EA 3A71A 4XMBA 3II7A 3ALWA 2A75A 1RWIA 1WCSA 3BEQA 2W8BA 1IVDA 4FOWA 1DILA 4MWUA 2QWEA 3SOBB 4GNCA 3H71A 5JYYA 2V91A 1L7FA 2VPJA
chains in the Genus database with same CATH topology
4IQKA 5FZJA 4IN4A 5FNSA 1ZGKA 3ADEA 3WDZA 3WN7A 2XN4A 1X2JA 2ZW9A 4IFLX 5F72C 4CH9A 4YY8A 2DYHA 4N1BA 5FNQA 3VNGA 1X2RA 5FNTA 5FNRA 4XMBA 3II7A 5FNUA 4ZGCA 4L7CA 5CGJA 1U6DX 4L7DA 2WOZA 3VNHA 2ZWAA 3ZGDA 2Z32A 2FLUX 2ZZKA 4ZY3A 4ASCA 4CHBA 5FZNA 4IFNX 3ZGCA 4IFJA 2VPJA 4L7BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IQK A;  5FZJ A;  4IN4 A;  5FNS A;  1ZGK A;  3ADE A;  3WDZ A;  3WN7 A;  2XN4 A;  1X2J A;  2ZW9 A;  4IFL X;  5F72 C;  4CH9 A;  4YY8 A;  2DYH A;  4N1B A;  5FNQ A;  3VNG A;  1X2R A;  5FNT A;  5FNR A;  4XMB A;  3II7 A;  5FNU A;  4ZGC A;  4L7C A;  5CGJ A;  1U6D X;  4L7D A;  2WOZ A;  3VNH A;  2ZWA A;  3ZGD A;  2Z32 A;  2FLU X;  2ZZK A;  4ZY3 A;  4ASC A;  4CHB A;  5FZN A;  4IFN X;  3ZGC A;  4IFJ A;  2VPJ A;  4L7B A; 
#chains in the Genus database with same CATH topology
 4MWR A;  4HZY A;  1VCJ A;  1C5K A;  5GTQ A;  4YY8 A;  2YA8 A;  2DYH A;  2F13 A;  1OFZ A;  2VSK A;  4FPK A;  1CQ1 A;  4G3N A;  2F28 A;  3SRG A;  1NSC A;  3DR2 A;  3NSS A;  2FP9 A;  2F25 A;  5EX7 A;  2W5N A;  4BBW A;  1W8N A;  3V65 B;  5GX2 A;  1WCQ A;  4IFN X;  3CL0 A;  4NC5 A;  4CPM A;  1SLI A;  1MS5 A;  3TI5 A;  3O9J A;  4GZX A;  5FNS A;  1V3E A;  2W5O A;  4AGI A;  2VK5 A;  4N1B A;  5FNQ A;  1V3C A;  4MX0 A;  2GVX A;  3H73 A;  4KS1 A;  4M4V A;  4GZP A;  4FVK A;  2ZB5 A;  4CPL A;  1B9S A;  3UC1 A;  2BF6 A;  2ZB6 A;  4X6K A;  2QWG A;  1IUC A;  3H72 A;  3CL2 A;  4Q1U A;  4ASC A;  4FPO B;  4GZQ A;  4D52 A;  3O9K A;  1W0P A;  3HRP A;  4CPO A;  5EO8 A;  2JKB A;  4K3Y A;  1F8D A;  4HIZ A;  4M4N A;  1ZI0 A;  1X2R A;  1EUU A;  3FW0 A;  2QWK A;  4D52 C;  4MZE A;  1INY A;  2YA5 A;  4FPC A;  1N1S A;  2FPB A;  3PJQ A;  4I00 A;  4HW6 A;  1W0O A;  4M4U A;  1XOE A;  3GVL A;  4FPH A;  1USR A;  1SUU A;  4X47 A;  3WDZ A;  1B9T A;  2ZW9 A;  4GEZ A;  3FVZ A;  4UOU A;  1F8C A;  3SRE A;  2AEP A;  2FP8 A;  1NSD A;  1S0J A;  1MR5 A;  2G8S A;  1MS0 A;  4MC7 A;  2POO A;  1KIT A;  4XIK A;  3V1S A;  1NMB N;  1NCD N;  3TC9 A;  1RWL A;  2XCY A;  1V0F A;  4QN5 A;  3INB A;  3SOV A;  4ZY3 A;  2ZZK A;  1V2I A;  5GX1 A;  4GZT A;  4L7B A;  1WP5 A;  2YA7 A;  3B69 A;  1NCA N;  2OJH A;  2HQS A;  3A9G A;  4YZ2 A;  4XIO A;  4XOG A;  4SLI A;  1A4Q A;  3U0S A;  2GVU A;  2QE8 A;  4GDJ A;  3HLI A;  3S94 A;  4L7C A;  2QWB A;  2GVW A;  4CPN A;  5EO7 A;  4YW1 A;  5HX0 A;  2IAO A;  4WA3 A;  4MWL A;  1IVF A;  4XE9 A;  4UF7 A;  4GZW A;  2AH2 A;  3Q6K A;  5NN9 A;  3ZGC A;  2B8H A;  1MS8 A;  2QWI A;  4GNB A;  5H47 A;  2P4O A;  4FPJ A;  2QWD A;  2SLI A;  2YDT A;  2H2N A;  4MWJ A;  1Q7F A;  4C1Y B;  2GHS A;  1K32 A;  4M3M A;  1INV A;  3A9H A;  3LI3 A;  4AHA A;  2H2U A;  5FNU A;  3K39 A;  1NNC A;  2C4L A;  1XOG A;  4GZO A;  2F26 A;  1N7D A;  1VCU A;  2FPC A;  4CHB A;  3TI3 A;  1N6E A;  4ZGC A;  1IVC A;  1V3B A;  4HZX A;  4K1H A;  5FNR A;  1QBI A;  4QNP A;  1INH A;  1ING A;  2QWA A;  2IAX A;  2HT8 A;  4NCS A;  5M1Z A;  3GVK A;  4KS4 A;  1F8E A;  2IAU A;  3G4E A;  4DGR A;  3D11 A;  2X9M A;  4A0P A;  4QN6 A;  4HHO A;  3DAS A;  4GJT A;  5GX5 A;  1NNB A;  1MS3 A;  2IAQ A;  2F29 A;  2VWD A;  1C9U A;  3KYA A;  5F72 C;  2XZI A;  4XJA A;  4XJ9 A;  3TI8 A;  4FOV A;  1USX A;  4XJ8 A;  5B2D A;  1W21 A;  4HZV A;  4XJU A;  4XJW A;  1NSB A;  1PJX A;  1INW A;  4O5S A;  4XJZ A;  1E1A A;  3IAX A;  2IAT A;  2W8B B;  1NN2 A;  1DIM A;  1MZ5 A;  1W20 A;  1IVB A;  4FOQ A;  4Q6K A;  4WA5 A;  1NCC N;  1CRZ A;  4KS3 A;  1SO7 A;  1IUB A;  4H53 A;  2FHR A;  1N1Y A;  2YA6 A;  4X4A A;  1EUT A;  4GN8 A;  3S8Z A;  1MWE A;  1IJQ A;  2IAW A;  4FPF A;  4FPG A;  1Z4Z A;  4L7D A;  2HU4 A;  2AEQ A;  4QN4 A;  4YW2 A;  4XHX A;  1EUS A;  2FLU X;  4GZS A;  2VW0 A;  4YW5 A;  4XIL A;  4FZH A;  4PWZ A;  1BJI A;  1SNT A;  4IQK A;  4MWV A;  1SLL A;  1L7G A;  4WEG A;  1MS1 A;  1A14 N;  3Q6T A;  4FP2 A;  3W09 A;  4MWW A;  4R40 A;  3P5B L;  2DSO A;  3SAL A;  1IVG A;  3LI4 A;  4MWY A;  2QWF A;  3CYE A;  4GN7 A;  2W20 A;  3OPZ A;  1H6L A;  1EUR A;  2VW1 A;  2F12 A;  2SIM A;  3ZGD A;  2F0Z A;  2IAS A;  1NMC A;  1E8V A;  4D8S A;  1E8T A;  2WOZ A;  4FQ4 A;  5D9B A;  4AGT A;  4D52 B;  1N1T A;  4FPE A;  4XMA A;  7NN9 A;  2YDP A;  5HUN A;  5GX4 A;  3K3A A;  3GVJ A;  4B7Q A;  3E5Z A;  3ALX A;  4CSD A;  2QWH A;  3SLI A;  4CPZ A;  4FPY A;  4IMB A;  4B7N A;  2RKC A;  1W8O A;  2DG1 A;  3K37 A;  4MWX A;  4MJV A;  2W38 A;  1CVM A;  4XYX A;  2ZWA A;  2VK6 A;  1V0E A;  4D4U A;  3TIA A;  2BZD A;  4XHB A;  2Z32 A;  1Z4X A;  3V64 C;  4IFJ A;  5FZJ A;  3CKZ A;  3ADE A;  5FWW A;  4DG6 A;  2HTQ A;  2XN4 A;  3K38 A;  4FP3 A;  3VNG A;  4XJQ A;  2GVV A;  3L6V A;  1POO A;  3BYC A;  6NN9 A;  2F11 A;  1N1V A;  4FOY A;  3I1C A;  2QWC A;  2HTY A;  3K36 A;  2HTW A;  1QLG A;  2HT7 A;  3Q6P A;  2BAT A;  1CRU A;  1Z4W A;  3SAN A;  1V04 A;  1MS9 A;  4MZA A;  5HUG A;  1F8B A;  4IN4 A;  3TI4 A;  3KGG A;  4HZZ A;  3G4H A;  3S2K A;  5D9C A;  1X2J A;  1MZ6 A;  4IFL X;  2F24 A;  2DG0 A;  4XJR A;  4YW3 A;  4FJ6 A;  4GB1 A;  4YW4 A;  5B2C A;  3JU4 A;  1MS4 A;  4YZ1 A;  4GN9 A;  4AH4 A;  1S0I A;  2IAV A;  1Z4Y A;  2CML A;  1Z4V A;  1N6D A;  4B7M A;  5CGJ A;  4GNA A;  1U6D X;  2AGS A;  4YZ4 A;  3NN9 A;  4FPL A;  4YZ5 A;  4H52 A;  4QN3 A;  5FZN A;  1V3D A;  2C4A A;  2XZK A;  4XMI A;  2HU0 A;  1V0Z A;  1N6F A;  2VW2 A;  1S1D A;  4ZLR A;  3WN7 A;  4C1Y A;  2BER A;  2VAQ A;  1IVE A;  1E8U A;  5HUM A;  4O5T A;  4J9T A;  1S18 A;  3NO0 A;  2HT5 A;  4KS2 A;  4MWQ A;  1NMA N;  1NCB N;  1Z50 A;  1INX A;  3AMS A;  4HZW A;  1A4G A;  3VNH A;  2ISM A;  3WWA A;  1L7H A;  2F27 A;  3H6J A;  2HTU A;  1B9V A;  5D9D A;  1NNA A;  3TIC A;  4QN7 A;  4IYG A;  3TIB A;  1INF A;  4NN9 A;  3WW9 A;  2F10 A;  1NPE A;  4K1I A;  4CH9 A;  3O4P A;  3AMR A;  1W1X A;  4KS5 A;  4YZ3 A;  4K1J A;  2IAP A;  4HHQ A;  2IVZ A;  2XZJ A;  3HLH A;  5F9T A;  3SOQ A;  2IAR A;  3S8V A;  4B7R A;  2HTR A;  2YA4 A;  2SIL A;  4MJU A;  3SIL A;  3A72 A;  4WEF A;  4CPY A;  4JF7 A;  4B7J A;  4K1K A;  3D12 A;  2VK7 A;  1ZGK A;  2VSM A;  3B7E A;  4WA4 A;  4X49 A;  2QWJ A;  4GDI A;  3TI6 A;  2HTV A;  5GX3 A;  5HUK A;  3LI5 A;  4JML A;  5FNT A;  2VVZ A;  3T1E A;  3A71 A;  4XMB A;  3II7 A;  3ALW A;  2A75 A;  1RWI A;  1WCS A;  3BEQ A;  2W8B A;  1IVD A;  4FOW A;  1DIL A;  4MWU A;  2QWE A;  3SOB B;  4GNC A;  3H71 A;  5JYY A;  2V91 A;  1L7F A;  2VPJ A; 
#chains in the Genus database with same CATH homology
 4IQK A;  5FZJ A;  4IN4 A;  5FNS A;  1ZGK A;  3ADE A;  3WDZ A;  3WN7 A;  2XN4 A;  1X2J A;  2ZW9 A;  4IFL X;  5F72 C;  4CH9 A;  4YY8 A;  2DYH A;  4N1B A;  5FNQ A;  3VNG A;  1X2R A;  5FNT A;  5FNR A;  4XMB A;  3II7 A;  5FNU A;  4ZGC A;  4L7C A;  5CGJ A;  1U6D X;  4L7D A;  2WOZ A;  3VNH A;  2ZWA A;  3ZGD A;  2Z32 A;  2FLU X;  2ZZK A;  4ZY3 A;  4ASC A;  4CHB A;  5FZN A;  4IFN X;  3ZGC A;  4IFJ A;  2VPJ A;  4L7B A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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