5F72C

De novo design and crystallographic validation of antibodies targeting a pre-selected epitope
Total Genus 62
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
62
sequence length
285
structure length
285
Chain Sequence
GRLIYTAGGYFRQSLSYLEAYNPSDGTWLDLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVT
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags De novo protein
molecule keywords Kelch-like ECH-associated protein 1
publication title De novo design and crystallographic validation of antibodies targeting a pre-selected epitope
rcsb
source organism Homo sapiens
total genus 62
structure length 285
sequence length 285
chains with identical sequence K
ec nomenclature
pdb deposition date 2015-12-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 5f72C00
5F72C 5CGJA 2ZWAA 3VNGA 4CH9A 4IFLX 5FNQA 1X2RA 4IFJA 4IN4A 5FZJA 4ASCA 4L7DA 5FZNA 4CHBA 4N1BA 3ADEA 4IQKA 3WN7A 5FNTA 2Z32A 5FNUA 3II7A 2ZZKA 2VPJA 3ZGCA 4L7BA 1ZGKA 4L7CA 4ZY3A 3VNHA 2FLUX 2WOZA 2XN4A 1U6DX 4XMBA 5FNSA 2DYHA 5FNRA 3WDZA 4YY8A 3ZGDA 4IFNX 2ZW9A 4ZGCA 1X2JA
chains in the Genus database with same CATH superfamily
4MWVA 4KS4A 4A0PA 3H72A 4MWLA 2BERA 2ZWAA 4MZEA 4GNAA 3W09A 4M3MA 4XE9A 4YZ2A 4XIKA 2XCYA 5FNUA 5HUNA 1S0IA 1OFZA 3KYAA 2QWAA 1USRA 3SREA 2IASA 4CPZA 3TIBA 4XJ8A 4GZTA 2BATA 5FNSA 4K1JA 3H71A 5FNRA 3SANA 2ZW9A 2F0ZA 2IAPA 4FPHA 2A75A 4CH9A 2YA5A 4FQ4A 3O9KA 2F10A 3GVJA 4XHXA 1IVEA 1W1XA 1N1TA 3H73A 4GZSA 5HUMA 4YW5A 3S8ZA 2QE8A 1NNAA 4B7QA 4QN3A 2HU4A 1V3DA 4FP3A 1Z50A 1N7DA 4MZAA 4GDJA 2HTWA 1BJIA 3KGGA 2W5OA 2FPBA 2C4AA 2QWJA 2VWDA 3BYCA 4ZGCA 3HLHA 4XJAA 4SLIA 5F72C 1B9SA 2FP8A 1NMCA 4B7MA 2RKCA 4R40A 3TI8A 2H2UA 1WCQA 2F27A 4CPLA 1INYA 4YZ3A 2FHRA 2JKBA 1ZI0A 1N6FA 2DSOA 1MS8A 1QLGA 1IVFA 4D8SA 4BBWA 4MC7A 4FOVA 3A71A 2GVXA 2GVUA 2IATA 1MS5A 2DG0A 1W20A 2B8HA 1K32A 2YA8A 1NCCN 1VCJA 2VK5A 4MX0A 3DR2A 2VSMA 4O5TA 2SIMA 2GVWA 4N1BA 4XJ9A 1IUBA 1V0ZA 3A9HA 4GN9A 2IARA 2QWGA 4MWUA 4YW2A 4L7CA 1W0PA 3V65B 1MZ5A 1Z4VA 4IFNX 1PJXA 1X2JA 3O4PA 1Z4WA 1NNBA 4IFLX 4HZVA 3AMRA 4FPGA 4D52C 4CHBA 1CVMA 5HUKA 5NN9A 4FPCA 1N1SA 4GNBA 1NCBN 3K38A 4CPMA 3Q6PA 1SUUA 3G4HA 4ZY3A 3A9GA 1NPEA 3WW9A 3WDZA 2QWEA 7NN9A 1EUSA 4YZ1A 4KS2A 2IAQA 1Z4XA 4GZQA 4ASCA 1C5KA 4XJQA 1L7GA 3D12A 4FPOB 4O5SA 2QWKA 5HX0A 1S1DA 3FW0A 3II7A 2VAQA 3NSSA 3CL2A 5GX1A 2FPCA 1IVDA 1Q7FA 4KS5A 2HTUA 3GVLA 1V3CA 5H47A 1KITA 1B9VA 4YW1A 1USXA 3TICA 3ALWA 4MWWA 3NN9A 2QWHA 1NSDA 3LI5A 4FPLA 4WEFA 1E8UA 4D52A 1V3EA 2VVZA 4ZLRA 1RWLA 4FOQA 4MWJA 2F29A 2IAUA 2IAOA 2AEPA 2HQSA 3OPZA 1N6EA 3SALA 1L7HA 4DGRA 1MZ6A 2G8SA 3S8VA 3VNHA 2W20A 4GZPA 1N1YA 2XN4A 3SILA 4FPEA 5D9DA 5F9TA 2VW1A 2F25A 2AH2A 4FJ6A 2V91A 1INHA 3HLIA 3VNGA 2HTQA 4GB1A 5B2DA 3V1SA 4YW4A 1A4QA 4GDIA 4JMLA 5GX3A 1MS9A 3B69A 3SOVA 4HZYA 1CQ1A 5M1ZA 3LI3A 4G3NA 5EX7A 1NSBA 3ZGCA 1A14N 2HT8A 1INGA 2POOA 2SLIA 4UF7A 1MR5A 4XMBA 2XZIA 1EURA 1CRZA 3K39A 1INVA 4HW6A 1F8CA 4WA3A 3HRPA 3Q6TA 4FZHA 2F26A 3AMSA 3L6VA 2IVZA 2YDPA 4C1YB 1IVCA 2HU0A 3O9JA 4NCSA 3WN7A 2ZZKA 4XILA 4IYGA 4B7JA 4GZWA 3S94A 4CPNA 1WCSA 3K3AA 2WOZA 3SLIA 3CKZA 1B9TA 2HTYA 1IJQA 1E8TA 3LI4A 1MS3A 2DG1A 4B7NA 3H6JA 1VCUA 1XOEA 2GHSA 3NO0A 6NN9A 5GX4A 1NN2A 2AGSA 1X2RA 3K37A 5FNQA 5EO8A 3FVZA 1NMBN 3P5BL 3SRGA 1XOGA 2F13A 2HTRA 4FPYA 4M4VA 4K3YA 2QWDA 2IAXA 1ZGKA 2CMLA 3U0SA 4AH4A 3PJQA 2ISMA 2QWBA 2DYHA 1W8NA 4DG6A 2HT7A 1IVGA 4HIZA 1MWEA 3CL0A 5D9CA 4AHAA 2OJHA 4Q1UA 3ALXA 4M4NA 5JYYA 4IN4A 4KS1A 1NMAN 4L7DA 4B7RA 4MWRA 4GZOA 1SNTA 1F8BA 4PWZA 1WP5A 1L7FA 4IMBA 4L7BA 4FVKA 4FOYA 1V2IA 1POOA 3DASA 4X47A 3WWAA 2F28A 1MS1A 1V04A 5D9BA 2C4LA 1CRUA 4GEZA 4XJUA 4QN4A 1Z4YA 4GN7A 3TIAA 4MJUA 3ADEA 1W21A 1V0FA 2QWFA 5GX2A 4J9TA 4XJWA 2VSKA 3A72A 2P4OA 4KS3A 4XYXA 1S0JA 2W5NA 3V64C 2VW0A 3Q6KA 4H52A 4XIOA 1EUUA 4GZXA 4MWYA 1V3BA 1NSCA 1N1VA 5CGJA 4X4AA 2HTVA 1QBIA 3S2KA 1F8EA 4XJZA 2F11A 4HHOA 2QWCA 4K1HA 4D4UA 1N6DA 4IQKA 4HZZA 1Z4ZA 4M4UA 2IAVA 5B2CA 1INXA 4YW3A 2W8BB 4XJRA 2BZDA 2FLUX 2XZJA 3IAXA 2X9MA 3UC1A 1IUCA 4YY8A 4X6KA 4MJVA 2F24A 4MWXA 2HT5A 4XHBA 3JU4A 2VK7A 1IVBA 4AGIA 4HHQA 1E1AA 5FZJA 4JF7A 1V0EA 4K1IA 1E8VA 2Z32A 4YZ4A 4K1KA 1NNCA 2XZKA 1INWA 4XMAA 2GVVA 4HZWA 4XOGA 2AEQA 1C9UA 2IAWA 3TI3A 3E5ZA 1EUTA 3TI5A 4YZ5A 1SLIA 4NC5A 5HUGA 4GNCA 1DILA 4XMIA 5GTQA 2VW2A 1F8DA 4UOUA 3G4EA 2W8BA 4MWQA 4WEGA 2ZB5A 4FP2A 4FPKA 3SOBB 3BEQA 4WA4A 2ZB6A 5FNTA 2YA4A 4FPFA 1RWIA 4X49A 1A4GA 4GN8A 3TC9A 1W8OA 4H53A 4GJTA 3K36A 3T1EA 2YDTA 1DIMA 4CSDA 4Q6KA 2QWIA 1H6LA 1U6DX 4C1YA 4AGTA 1MS0A 1NCAN 3ZGDA 4FOWA 2SILA 2YA6A 1SLLA 4QNPA 1W0OA 4FPJA 3D11A 5GX5A 4QN6A 2F12A 2FP9A 3TI4A 4NN9A 4IFJA 5FWWA 4QN7A 5FZNA 3GVKA 4I00A 4HZXA 2VK6A 3SOQA 3CYEA 3TI6A 4CPOA 1INFA 1S18A 3B7EA 2BF6A 2VPJA 2YA7A 1SO7A 4D52B 4WA5A 1NCDN 4QN5A 1MS4A 2H2NA 3I1CA 2W38A 4CPYA 5EO7A 3INBA
chains in the Genus database with same CATH topology
5F72C 5CGJA 2ZWAA 3VNGA 4CH9A 4IFLX 5FNQA 1X2RA 4IFJA 4IN4A 5FZJA 4ASCA 4L7DA 5FZNA 4CHBA 4N1BA 3ADEA 4IQKA 3WN7A 5FNTA 2Z32A 5FNUA 3II7A 2ZZKA 2VPJA 3ZGCA 4L7BA 1ZGKA 4L7CA 4ZY3A 3VNHA 2FLUX 2WOZA 2XN4A 1U6DX 4XMBA 5FNSA 2DYHA 5FNRA 3WDZA 4YY8A 3ZGDA 4IFNX 2ZW9A 4ZGCA 1X2JA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5F72 C;  5CGJ A;  2ZWA A;  3VNG A;  4CH9 A;  4IFL X;  5FNQ A;  1X2R A;  4IFJ A;  4IN4 A;  5FZJ A;  4ASC A;  4L7D A;  5FZN A;  4CHB A;  4N1B A;  3ADE A;  4IQK A;  3WN7 A;  5FNT A;  2Z32 A;  5FNU A;  3II7 A;  2ZZK A;  2VPJ A;  3ZGC A;  4L7B A;  1ZGK A;  4L7C A;  4ZY3 A;  3VNH A;  2FLU X;  2WOZ A;  2XN4 A;  1U6D X;  4XMB A;  5FNS A;  2DYH A;  5FNR A;  3WDZ A;  4YY8 A;  3ZGD A;  4IFN X;  2ZW9 A;  4ZGC A;  1X2J A; 
#chains in the Genus database with same CATH topology
 4MWV A;  4KS4 A;  4A0P A;  3H72 A;  4MWL A;  2BER A;  2ZWA A;  4MZE A;  4GNA A;  3W09 A;  4M3M A;  4XE9 A;  4YZ2 A;  4XIK A;  2XCY A;  5FNU A;  5HUN A;  1S0I A;  1OFZ A;  3KYA A;  2QWA A;  1USR A;  3SRE A;  2IAS A;  4CPZ A;  3TIB A;  4XJ8 A;  4GZT A;  2BAT A;  5FNS A;  4K1J A;  3H71 A;  5FNR A;  3SAN A;  2ZW9 A;  2F0Z A;  2IAP A;  4FPH A;  2A75 A;  4CH9 A;  2YA5 A;  4FQ4 A;  3O9K A;  2F10 A;  3GVJ A;  4XHX A;  1IVE A;  1W1X A;  1N1T A;  3H73 A;  4GZS A;  5HUM A;  4YW5 A;  3S8Z A;  2QE8 A;  1NNA A;  4B7Q A;  4QN3 A;  2HU4 A;  1V3D A;  4FP3 A;  1Z50 A;  1N7D A;  4MZA A;  4GDJ A;  2HTW A;  1BJI A;  3KGG A;  2W5O A;  2FPB A;  2C4A A;  2QWJ A;  2VWD A;  3BYC A;  4ZGC A;  3HLH A;  4XJA A;  4SLI A;  5F72 C;  1B9S A;  2FP8 A;  1NMC A;  4B7M A;  2RKC A;  4R40 A;  3TI8 A;  2H2U A;  1WCQ A;  2F27 A;  4CPL A;  1INY A;  4YZ3 A;  2FHR A;  2JKB A;  1ZI0 A;  1N6F A;  2DSO A;  1MS8 A;  1QLG A;  1IVF A;  4D8S A;  4BBW A;  4MC7 A;  4FOV A;  3A71 A;  2GVX A;  2GVU A;  2IAT A;  1MS5 A;  2DG0 A;  1W20 A;  2B8H A;  1K32 A;  2YA8 A;  1NCC N;  1VCJ A;  2VK5 A;  4MX0 A;  3DR2 A;  2VSM A;  4O5T A;  2SIM A;  2GVW A;  4N1B A;  4XJ9 A;  1IUB A;  1V0Z A;  3A9H A;  4GN9 A;  2IAR A;  2QWG A;  4MWU A;  4YW2 A;  4L7C A;  1W0P A;  3V65 B;  1MZ5 A;  1Z4V A;  4IFN X;  1PJX A;  1X2J A;  3O4P A;  1Z4W A;  1NNB A;  4IFL X;  4HZV A;  3AMR A;  4FPG A;  4D52 C;  4CHB A;  1CVM A;  5HUK A;  5NN9 A;  4FPC A;  1N1S A;  4GNB A;  1NCB N;  3K38 A;  4CPM A;  3Q6P A;  1SUU A;  3G4H A;  4ZY3 A;  3A9G A;  1NPE A;  3WW9 A;  3WDZ A;  2QWE A;  7NN9 A;  1EUS A;  4YZ1 A;  4KS2 A;  2IAQ A;  1Z4X A;  4GZQ A;  4ASC A;  1C5K A;  4XJQ A;  1L7G A;  3D12 A;  4FPO B;  4O5S A;  2QWK A;  5HX0 A;  1S1D A;  3FW0 A;  3II7 A;  2VAQ A;  3NSS A;  3CL2 A;  5GX1 A;  2FPC A;  1IVD A;  1Q7F A;  4KS5 A;  2HTU A;  3GVL A;  1V3C A;  5H47 A;  1KIT A;  1B9V A;  4YW1 A;  1USX A;  3TIC A;  3ALW A;  4MWW A;  3NN9 A;  2QWH A;  1NSD A;  3LI5 A;  4FPL A;  4WEF A;  1E8U A;  4D52 A;  1V3E A;  2VVZ A;  4ZLR A;  1RWL A;  4FOQ A;  4MWJ A;  2F29 A;  2IAU A;  2IAO A;  2AEP A;  2HQS A;  3OPZ A;  1N6E A;  3SAL A;  1L7H A;  4DGR A;  1MZ6 A;  2G8S A;  3S8V A;  3VNH A;  2W20 A;  4GZP A;  1N1Y A;  2XN4 A;  3SIL A;  4FPE A;  5D9D A;  5F9T A;  2VW1 A;  2F25 A;  2AH2 A;  4FJ6 A;  2V91 A;  1INH A;  3HLI A;  3VNG A;  2HTQ A;  4GB1 A;  5B2D A;  3V1S A;  4YW4 A;  1A4Q A;  4GDI A;  4JML A;  5GX3 A;  1MS9 A;  3B69 A;  3SOV A;  4HZY A;  1CQ1 A;  5M1Z A;  3LI3 A;  4G3N A;  5EX7 A;  1NSB A;  3ZGC A;  1A14 N;  2HT8 A;  1ING A;  2POO A;  2SLI A;  4UF7 A;  1MR5 A;  4XMB A;  2XZI A;  1EUR A;  1CRZ A;  3K39 A;  1INV A;  4HW6 A;  1F8C A;  4WA3 A;  3HRP A;  3Q6T A;  4FZH A;  2F26 A;  3AMS A;  3L6V A;  2IVZ A;  2YDP A;  4C1Y B;  1IVC A;  2HU0 A;  3O9J A;  4NCS A;  3WN7 A;  2ZZK A;  4XIL A;  4IYG A;  4B7J A;  4GZW A;  3S94 A;  4CPN A;  1WCS A;  3K3A A;  2WOZ A;  3SLI A;  3CKZ A;  1B9T A;  2HTY A;  1IJQ A;  1E8T A;  3LI4 A;  1MS3 A;  2DG1 A;  4B7N A;  3H6J A;  1VCU A;  1XOE A;  2GHS A;  3NO0 A;  6NN9 A;  5GX4 A;  1NN2 A;  2AGS A;  1X2R A;  3K37 A;  5FNQ A;  5EO8 A;  3FVZ A;  1NMB N;  3P5B L;  3SRG A;  1XOG A;  2F13 A;  2HTR A;  4FPY A;  4M4V A;  4K3Y A;  2QWD A;  2IAX A;  1ZGK A;  2CML A;  3U0S A;  4AH4 A;  3PJQ A;  2ISM A;  2QWB A;  2DYH A;  1W8N A;  4DG6 A;  2HT7 A;  1IVG A;  4HIZ A;  1MWE A;  3CL0 A;  5D9C A;  4AHA A;  2OJH A;  4Q1U A;  3ALX A;  4M4N A;  5JYY A;  4IN4 A;  4KS1 A;  1NMA N;  4L7D A;  4B7R A;  4MWR A;  4GZO A;  1SNT A;  1F8B A;  4PWZ A;  1WP5 A;  1L7F A;  4IMB A;  4L7B A;  4FVK A;  4FOY A;  1V2I A;  1POO A;  3DAS A;  4X47 A;  3WWA A;  2F28 A;  1MS1 A;  1V04 A;  5D9B A;  2C4L A;  1CRU A;  4GEZ A;  4XJU A;  4QN4 A;  1Z4Y A;  4GN7 A;  3TIA A;  4MJU A;  3ADE A;  1W21 A;  1V0F A;  2QWF A;  5GX2 A;  4J9T A;  4XJW A;  2VSK A;  3A72 A;  2P4O A;  4KS3 A;  4XYX A;  1S0J A;  2W5N A;  3V64 C;  2VW0 A;  3Q6K A;  4H52 A;  4XIO A;  1EUU A;  4GZX A;  4MWY A;  1V3B A;  1NSC A;  1N1V A;  5CGJ A;  4X4A A;  2HTV A;  1QBI A;  3S2K A;  1F8E A;  4XJZ A;  2F11 A;  4HHO A;  2QWC A;  4K1H A;  4D4U A;  1N6D A;  4IQK A;  4HZZ A;  1Z4Z A;  4M4U A;  2IAV A;  5B2C A;  1INX A;  4YW3 A;  2W8B B;  4XJR A;  2BZD A;  2FLU X;  2XZJ A;  3IAX A;  2X9M A;  3UC1 A;  1IUC A;  4YY8 A;  4X6K A;  4MJV A;  2F24 A;  4MWX A;  2HT5 A;  4XHB A;  3JU4 A;  2VK7 A;  1IVB A;  4AGI A;  4HHQ A;  1E1A A;  5FZJ A;  4JF7 A;  1V0E A;  4K1I A;  1E8V A;  2Z32 A;  4YZ4 A;  4K1K A;  1NNC A;  2XZK A;  1INW A;  4XMA A;  2GVV A;  4HZW A;  4XOG A;  2AEQ A;  1C9U A;  2IAW A;  3TI3 A;  3E5Z A;  1EUT A;  3TI5 A;  4YZ5 A;  1SLI A;  4NC5 A;  5HUG A;  4GNC A;  1DIL A;  4XMI A;  5GTQ A;  2VW2 A;  1F8D A;  4UOU A;  3G4E A;  2W8B A;  4MWQ A;  4WEG A;  2ZB5 A;  4FP2 A;  4FPK A;  3SOB B;  3BEQ A;  4WA4 A;  2ZB6 A;  5FNT A;  2YA4 A;  4FPF A;  1RWI A;  4X49 A;  1A4G A;  4GN8 A;  3TC9 A;  1W8O A;  4H53 A;  4GJT A;  3K36 A;  3T1E A;  2YDT A;  1DIM A;  4CSD A;  4Q6K A;  2QWI A;  1H6L A;  1U6D X;  4C1Y A;  4AGT A;  1MS0 A;  1NCA N;  3ZGD A;  4FOW A;  2SIL A;  2YA6 A;  1SLL A;  4QNP A;  1W0O A;  4FPJ A;  3D11 A;  5GX5 A;  4QN6 A;  2F12 A;  2FP9 A;  3TI4 A;  4NN9 A;  4IFJ A;  5FWW A;  4QN7 A;  5FZN A;  3GVK A;  4I00 A;  4HZX A;  2VK6 A;  3SOQ A;  3CYE A;  3TI6 A;  4CPO A;  1INF A;  1S18 A;  3B7E A;  2BF6 A;  2VPJ A;  2YA7 A;  1SO7 A;  4D52 B;  4WA5 A;  1NCD N;  4QN5 A;  1MS4 A;  2H2N A;  3I1C A;  2W38 A;  4CPY A;  5EO7 A;  3INB A; 
#chains in the Genus database with same CATH homology
 5F72 C;  5CGJ A;  2ZWA A;  3VNG A;  4CH9 A;  4IFL X;  5FNQ A;  1X2R A;  4IFJ A;  4IN4 A;  5FZJ A;  4ASC A;  4L7D A;  5FZN A;  4CHB A;  4N1B A;  3ADE A;  4IQK A;  3WN7 A;  5FNT A;  2Z32 A;  5FNU A;  3II7 A;  2ZZK A;  2VPJ A;  3ZGC A;  4L7B A;  1ZGK A;  4L7C A;  4ZY3 A;  3VNH A;  2FLU X;  2WOZ A;  2XN4 A;  1U6D X;  4XMB A;  5FNS A;  2DYH A;  5FNR A;  3WDZ A;  4YY8 A;  3ZGD A;  4IFN X;  2ZW9 A;  4ZGC A;  1X2J A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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