5FNRA

Structure of the keap1 kelch domain in complex with a small molecule inhibitor.
Total Genus 65
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
65
sequence length
289
structure length
289
Chain Sequence
GRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transcription
molecule keywords KELCH-LIKE ECH-ASSOCIATED PROTEIN 1
publication title Mono-Acidic Inhibitors of the Kelch-Like Ech-Associated Protein 1 : Nuclear Factor Erythroid 2-Related Factor 2 (Keap1:Nrf2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
pubmed doi rcsb
source organism Mus musculus
total genus 65
structure length 289
sequence length 289
ec nomenclature
pdb deposition date 2015-11-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 5fnrA00
3WN7A 1ZGKA 4IFNX 5FNTA 1X2JA 5CGJA 4L7BA 4ZY3A 2ZZKA 3WDZA 3ZGDA 3ZGCA 5FNSA 2VPJA 1U6DX 2FLUX 2WOZA 2ZWAA 4IFLX 4IN4A 3II7A 3VNGA 4IQKA 5FZNA 4L7CA 2DYHA 4N1BA 5F72C 5FNRA 4ZGCA 5FZJA 4YY8A 4IFJA 4XMBA 1X2RA 4ASCA 4L7DA 5FNQA 5FNUA 2XN4A 2Z32A 2ZW9A 4CH9A 3ADEA 4CHBA 3VNHA
chains in the Genus database with same CATH superfamily
4D52A 1NNBA 3H72A 1E8TA 1SNTA 2VW2A 4X49A 1IUBA 1A14N 1E1AA 2DG0A 1EUUA 4HZXA 4YW1A 5NN9A 5GX5A 5FNRA 3TC9A 4X47A 1S0JA 5FZJA 1L7FA 3L6VA 2FP9A 5H47A 2VK6A 4XIOA 2BF6A 3DR2A 3A72A 4FQ4A 1NSCA 1E8UA 2XN4A 1NNAA 4ZLRA 3SILA 4CH9A 4XJZA 1IVCA 2VVZA 4YW4A 3Q6PA 1Z4WA 3TI8A 4YW2A 2HU4A 2HTQA 4D52C 4KS1A 1Z4YA 1EURA 4CSDA 1SLIA 1C5KA 5D9DA 3TI3A 3SLIA 2SIMA 4FPLA 1KITA 4GNAA 1F8BA 1W0OA 4PWZA 1X2RA 1F8DA 2JKBA 2QWFA 1NNCA 2BZDA 5B2CA 1N7DA 1W20A 2F25A 3VNHA 1EUSA 4H53A 3WN7A 4IMBA 4QN3A 3ZGDA 3NSSA 2FP8A 1N6DA 1K32A 1NCAN 4IFLX 3II7A 2X9MA 4CPNA 4DG6A 4ZGCA 2W5NA 4K1HA 4K1KA 4MWYA 4GZOA 2ZW9A 2SLIA 2IARA 3V65B 2QWKA 3TIAA 3BEQA 2POOA 2QWGA 4A0PA 3K36A 1X2JA 4M4VA 3O9JA 5FNSA 1MZ5A 1INHA 3I1CA 2HTWA 3BYCA 1C9UA 4J9TA 3TICA 4XILA 4CPLA 4XMBA 4CPYA 5JYYA 4XJ8A 2YA4A 4KS4A 5EO7A 1A4GA 2IAXA 1MZ6A 3B69A 1MS8A 1V3EA 3Q6TA 4XMIA 1S0IA 4FPOB 4GZSA 2F29A 4M4UA 1F8CA 2ZWAA 3V1SA 2XZIA 1INGA 2C4AA 4C1YB 1CRUA 4B7RA 5F72C 4QN5A 4NCSA 2F13A 4O5TA 4UOUA 2HTVA 2OJHA 1V2IA 4XJAA 3H73A 4CHBA 1DIMA 3ALXA 1NCBN 4AGIA 3D11A 1MR5A 1SLLA 4QN4A 1Q7FA 4B7JA 3O9KA 4MX0A 4MJVA 1U6DX 2FLUX 4FP2A 1OFZA 3CKZA 1CQ1A 1V0EA 3T1EA 4L7CA 3WWAA 1S1DA 2W38A 1B9SA 3HLIA 4D8SA 2HTYA 6NN9A 2IAUA 1NCCN 7NN9A 2ZB6A 4M3MA 4YZ3A 1POOA 4D4UA 1B9VA 1N1VA 3S2KA 4MWUA 2V91A 5FWWA 2VW1A 2YA5A 4HZYA 4FPFA 1MS1A 4Q1UA 4MWWA 2YA6A 2XZJA 1N6EA 1W8OA 3OPZA 4CPMA 4XJWA 3TIBA 3KYAA 4XHBA 2IAOA 2FHRA 1VCUA 4GZPA 1INWA 1L7HA 4MC7A 4K3YA 1V3BA 2P4OA 3B7EA 3G4EA 5GX3A 4AHAA 2HT8A 2VSKA 4NC5A 5B2DA 3SOVA 2F10A 4YZ1A 3E5ZA 4FPGA 2GVVA 2WOZA 4FP3A 4CPOA 3SOBB 2VK7A 3K38A 4D52B 3Q6KA 1IVFA 1USXA 1N1TA 1W8NA 4YY8A 3TI6A 1QBIA 4WA5A 4XIKA 1MS9A 5HUMA 2RKCA 1SO7A 5HUNA 4WEFA 2GVXA 4MWQA 4MZAA 2W8BA 1BJIA 2BERA 5CGJA 4GDIA 4JMLA 3AMRA 3ZGCA 1V3CA 2QWEA 4MWRA 3P5BL 3A9GA 1INXA 1V0ZA 1NPEA 1CRZA 1VCJA 4QNPA 3GVKA 3HLHA 5GTQA 1IVGA 4QN7A 2VW0A 4BBWA 2QWDA 2QWJA 4ASCA 4L7DA 2HTRA 1Z4ZA 2CMLA 4B7NA 4AGTA 2FPBA 1NSBA 4YZ2A 2H2UA 4YW3A 4XE9A 2F11A 1WCSA 2BATA 1INFA 4HW6A 3VNGA 2AH2A 3AMSA 4IQKA 4XYXA 2HU0A 5GX4A 1W0PA 5HUKA 4Q6KA 4HZVA 1IVBA 3LI3A 1PJXA 4MWLA 5GX2A 2QWBA 4GN7A 1NMBN 4MZEA 4FPCA 4HZWA 2F27A 2QWAA 2G8SA 2YDTA 2IAQA 4JF7A 4CPZA 1WP5A 3K3AA 1W1XA 2B8HA 4FPYA 4G3NA 1DILA 4SLIA 2HTUA 1Z50A 2C4LA 1N1SA 2VWDA 4GB1A 3S94A 4K1IA 1RWIA 1MS5A 1RWLA 3LI4A 3INBA 3W09A 2SILA 4XJRA 4X4AA 1IJQA 1NCDN 3CL0A 2F24A 4FOYA 2IATA 1S18A 4HHQA 4FPJA 1NN2A 1XOEA 4XHXA 3HRPA 2QE8A 2H2NA 4X6KA 4M4NA 1L7GA 1F8EA 3TI4A 3FVZA 4KS2A 3SRGA 3IAXA 1IVEA 4N1BA 4FPEA 5D9CA 2GHSA 2F0ZA 4GZXA 1W21A 4XOGA 3K37A 5FNUA 3SREA 2F28A 4GN9A 1MWEA 4H52A 4MWVA 3FW0A 2GVWA 5EX7A 5D9BA 2AGSA 4NN9A 1USRA 1NMCA 1MS0A 4YW5A 3TI5A 1MS3A 2FPCA 4YZ4A 2W20A 4ZY3A 4GZQA 2ZZKA 1INYA 3A71A 1NSDA 1V0FA 3H71A 4AH4A 1IVDA 1EUTA 4FPHA 4IN4A 2F12A 4IYGA 2VK5A 4MWJA 1QLGA 3SALA 4FOQA 4QN6A 5HUGA 4WEGA 4KS3A 2IAPA 1SUUA 3ADEA 4UF7A 4HIZA 1Z4VA 2VAQA 4C1YA 2GVUA 3CYEA 2HT7A 4I00A 3ALWA 4MJUA 2IAVA 4B7QA 2F26A 3S8ZA 1B9TA 2QWHA 3CL2A 5FZNA 2YDPA 4FVKA 2QWIA 5GX1A 4IFJA 3DASA 1A4QA 1N1YA 4DGRA 4GZTA 3A9HA 3D12A 3O4PA 3JU4A 1INVA 3SOQA 3WW9A 2VSMA 2YA8A 4GNBA 1ZGKA 1V04A 4KS5A 4FOVA 4O5SA 4HZZA 1N6FA 4YZ5A 4GN8A 5F9TA 2QWCA 1V3DA 2IVZA 2A75A 2DG1A 4WA4A 2DYHA 3S8VA 4FJ6A 1ZI0A 2W5OA 3H6JA 2XCYA 1NMAN 3U0SA 3G4HA 2AEQA 2DSOA 2YA7A 2AEPA 3UC1A 3V64C 4K1JA 4FOWA 2Z32A 2IAWA 2ISMA 5EO8A 3NO0A 4GJTA 3GVLA 2XZKA 4GDJA 2HQSA 5M1ZA 4XMAA 1MS4A 4IFNX 5FNTA 4FZHA 2ZB5A 4L7BA 3WDZA 4MWXA 2VPJA 4FPKA 1IUCA 4HHOA 2W8BB 4XJ9A 3NN9A 1WCQA 1CVMA 4GZWA 1E8VA 1Z4XA 3GVJA 3PJQA 4B7MA 1XOGA 4R40A 4GEZA 4XJQA 3LI5A 3SANA 4XJUA 2IASA 5FNQA 3K39A 4GNCA 1H6LA 2HT5A 4WA3A 3KGGA 5HX0A
chains in the Genus database with same CATH topology
3WN7A 1ZGKA 4IFNX 5FNTA 1X2JA 5CGJA 4L7BA 4ZY3A 2ZZKA 3WDZA 3ZGDA 3ZGCA 5FNSA 2VPJA 1U6DX 2FLUX 2WOZA 2ZWAA 4IFLX 4IN4A 3II7A 3VNGA 4IQKA 5FZNA 4L7CA 2DYHA 4N1BA 5F72C 5FNRA 4ZGCA 5FZJA 4YY8A 4IFJA 4XMBA 1X2RA 4ASCA 4L7DA 5FNQA 5FNUA 2XN4A 2Z32A 2ZW9A 4CH9A 3ADEA 4CHBA 3VNHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3WN7 A;  1ZGK A;  4IFN X;  5FNT A;  1X2J A;  5CGJ A;  4L7B A;  4ZY3 A;  2ZZK A;  3WDZ A;  3ZGD A;  3ZGC A;  5FNS A;  2VPJ A;  1U6D X;  2FLU X;  2WOZ A;  2ZWA A;  4IFL X;  4IN4 A;  3II7 A;  3VNG A;  4IQK A;  5FZN A;  4L7C A;  2DYH A;  4N1B A;  5F72 C;  5FNR A;  4ZGC A;  5FZJ A;  4YY8 A;  4IFJ A;  4XMB A;  1X2R A;  4ASC A;  4L7D A;  5FNQ A;  5FNU A;  2XN4 A;  2Z32 A;  2ZW9 A;  4CH9 A;  3ADE A;  4CHB A;  3VNH A; 
#chains in the Genus database with same CATH topology
 4D52 A;  1NNB A;  3H72 A;  1E8T A;  1SNT A;  2VW2 A;  4X49 A;  1IUB A;  1A14 N;  1E1A A;  2DG0 A;  1EUU A;  4HZX A;  4YW1 A;  5NN9 A;  5GX5 A;  5FNR A;  3TC9 A;  4X47 A;  1S0J A;  5FZJ A;  1L7F A;  3L6V A;  2FP9 A;  5H47 A;  2VK6 A;  4XIO A;  2BF6 A;  3DR2 A;  3A72 A;  4FQ4 A;  1NSC A;  1E8U A;  2XN4 A;  1NNA A;  4ZLR A;  3SIL A;  4CH9 A;  4XJZ A;  1IVC A;  2VVZ A;  4YW4 A;  3Q6P A;  1Z4W A;  3TI8 A;  4YW2 A;  2HU4 A;  2HTQ A;  4D52 C;  4KS1 A;  1Z4Y A;  1EUR A;  4CSD A;  1SLI A;  1C5K A;  5D9D A;  3TI3 A;  3SLI A;  2SIM A;  4FPL A;  1KIT A;  4GNA A;  1F8B A;  1W0O A;  4PWZ A;  1X2R A;  1F8D A;  2JKB A;  2QWF A;  1NNC A;  2BZD A;  5B2C A;  1N7D A;  1W20 A;  2F25 A;  3VNH A;  1EUS A;  4H53 A;  3WN7 A;  4IMB A;  4QN3 A;  3ZGD A;  3NSS A;  2FP8 A;  1N6D A;  1K32 A;  1NCA N;  4IFL X;  3II7 A;  2X9M A;  4CPN A;  4DG6 A;  4ZGC A;  2W5N A;  4K1H A;  4K1K A;  4MWY A;  4GZO A;  2ZW9 A;  2SLI A;  2IAR A;  3V65 B;  2QWK A;  3TIA A;  3BEQ A;  2POO A;  2QWG A;  4A0P A;  3K36 A;  1X2J A;  4M4V A;  3O9J A;  5FNS A;  1MZ5 A;  1INH A;  3I1C A;  2HTW A;  3BYC A;  1C9U A;  4J9T A;  3TIC A;  4XIL A;  4CPL A;  4XMB A;  4CPY A;  5JYY A;  4XJ8 A;  2YA4 A;  4KS4 A;  5EO7 A;  1A4G A;  2IAX A;  1MZ6 A;  3B69 A;  1MS8 A;  1V3E A;  3Q6T A;  4XMI A;  1S0I A;  4FPO B;  4GZS A;  2F29 A;  4M4U A;  1F8C A;  2ZWA A;  3V1S A;  2XZI A;  1ING A;  2C4A A;  4C1Y B;  1CRU A;  4B7R A;  5F72 C;  4QN5 A;  4NCS A;  2F13 A;  4O5T A;  4UOU A;  2HTV A;  2OJH A;  1V2I A;  4XJA A;  3H73 A;  4CHB A;  1DIM A;  3ALX A;  1NCB N;  4AGI A;  3D11 A;  1MR5 A;  1SLL A;  4QN4 A;  1Q7F A;  4B7J A;  3O9K A;  4MX0 A;  4MJV A;  1U6D X;  2FLU X;  4FP2 A;  1OFZ A;  3CKZ A;  1CQ1 A;  1V0E A;  3T1E A;  4L7C A;  3WWA A;  1S1D A;  2W38 A;  1B9S A;  3HLI A;  4D8S A;  2HTY A;  6NN9 A;  2IAU A;  1NCC N;  7NN9 A;  2ZB6 A;  4M3M A;  4YZ3 A;  1POO A;  4D4U A;  1B9V A;  1N1V A;  3S2K A;  4MWU A;  2V91 A;  5FWW A;  2VW1 A;  2YA5 A;  4HZY A;  4FPF A;  1MS1 A;  4Q1U A;  4MWW A;  2YA6 A;  2XZJ A;  1N6E A;  1W8O A;  3OPZ A;  4CPM A;  4XJW A;  3TIB A;  3KYA A;  4XHB A;  2IAO A;  2FHR A;  1VCU A;  4GZP A;  1INW A;  1L7H A;  4MC7 A;  4K3Y A;  1V3B A;  2P4O A;  3B7E A;  3G4E A;  5GX3 A;  4AHA A;  2HT8 A;  2VSK A;  4NC5 A;  5B2D A;  3SOV A;  2F10 A;  4YZ1 A;  3E5Z A;  4FPG A;  2GVV A;  2WOZ A;  4FP3 A;  4CPO A;  3SOB B;  2VK7 A;  3K38 A;  4D52 B;  3Q6K A;  1IVF A;  1USX A;  1N1T A;  1W8N A;  4YY8 A;  3TI6 A;  1QBI A;  4WA5 A;  4XIK A;  1MS9 A;  5HUM A;  2RKC A;  1SO7 A;  5HUN A;  4WEF A;  2GVX A;  4MWQ A;  4MZA A;  2W8B A;  1BJI A;  2BER A;  5CGJ A;  4GDI A;  4JML A;  3AMR A;  3ZGC A;  1V3C A;  2QWE A;  4MWR A;  3P5B L;  3A9G A;  1INX A;  1V0Z A;  1NPE A;  1CRZ A;  1VCJ A;  4QNP A;  3GVK A;  3HLH A;  5GTQ A;  1IVG A;  4QN7 A;  2VW0 A;  4BBW A;  2QWD A;  2QWJ A;  4ASC A;  4L7D A;  2HTR A;  1Z4Z A;  2CML A;  4B7N A;  4AGT A;  2FPB A;  1NSB A;  4YZ2 A;  2H2U A;  4YW3 A;  4XE9 A;  2F11 A;  1WCS A;  2BAT A;  1INF A;  4HW6 A;  3VNG A;  2AH2 A;  3AMS A;  4IQK A;  4XYX A;  2HU0 A;  5GX4 A;  1W0P A;  5HUK A;  4Q6K A;  4HZV A;  1IVB A;  3LI3 A;  1PJX A;  4MWL A;  5GX2 A;  2QWB A;  4GN7 A;  1NMB N;  4MZE A;  4FPC A;  4HZW A;  2F27 A;  2QWA A;  2G8S A;  2YDT A;  2IAQ A;  4JF7 A;  4CPZ A;  1WP5 A;  3K3A A;  1W1X A;  2B8H A;  4FPY A;  4G3N A;  1DIL A;  4SLI A;  2HTU A;  1Z50 A;  2C4L A;  1N1S A;  2VWD A;  4GB1 A;  3S94 A;  4K1I A;  1RWI A;  1MS5 A;  1RWL A;  3LI4 A;  3INB A;  3W09 A;  2SIL A;  4XJR A;  4X4A A;  1IJQ A;  1NCD N;  3CL0 A;  2F24 A;  4FOY A;  2IAT A;  1S18 A;  4HHQ A;  4FPJ A;  1NN2 A;  1XOE A;  4XHX A;  3HRP A;  2QE8 A;  2H2N A;  4X6K A;  4M4N A;  1L7G A;  1F8E A;  3TI4 A;  3FVZ A;  4KS2 A;  3SRG A;  3IAX A;  1IVE A;  4N1B A;  4FPE A;  5D9C A;  2GHS A;  2F0Z A;  4GZX A;  1W21 A;  4XOG A;  3K37 A;  5FNU A;  3SRE A;  2F28 A;  4GN9 A;  1MWE A;  4H52 A;  4MWV A;  3FW0 A;  2GVW A;  5EX7 A;  5D9B A;  2AGS A;  4NN9 A;  1USR A;  1NMC A;  1MS0 A;  4YW5 A;  3TI5 A;  1MS3 A;  2FPC A;  4YZ4 A;  2W20 A;  4ZY3 A;  4GZQ A;  2ZZK A;  1INY A;  3A71 A;  1NSD A;  1V0F A;  3H71 A;  4AH4 A;  1IVD A;  1EUT A;  4FPH A;  4IN4 A;  2F12 A;  4IYG A;  2VK5 A;  4MWJ A;  1QLG A;  3SAL A;  4FOQ A;  4QN6 A;  5HUG A;  4WEG A;  4KS3 A;  2IAP A;  1SUU A;  3ADE A;  4UF7 A;  4HIZ A;  1Z4V A;  2VAQ A;  4C1Y A;  2GVU A;  3CYE A;  2HT7 A;  4I00 A;  3ALW A;  4MJU A;  2IAV A;  4B7Q A;  2F26 A;  3S8Z A;  1B9T A;  2QWH A;  3CL2 A;  5FZN A;  2YDP A;  4FVK A;  2QWI A;  5GX1 A;  4IFJ A;  3DAS A;  1A4Q A;  1N1Y A;  4DGR A;  4GZT A;  3A9H A;  3D12 A;  3O4P A;  3JU4 A;  1INV A;  3SOQ A;  3WW9 A;  2VSM A;  2YA8 A;  4GNB A;  1ZGK A;  1V04 A;  4KS5 A;  4FOV A;  4O5S A;  4HZZ A;  1N6F A;  4YZ5 A;  4GN8 A;  5F9T A;  2QWC A;  1V3D A;  2IVZ A;  2A75 A;  2DG1 A;  4WA4 A;  2DYH A;  3S8V A;  4FJ6 A;  1ZI0 A;  2W5O A;  3H6J A;  2XCY A;  1NMA N;  3U0S A;  3G4H A;  2AEQ A;  2DSO A;  2YA7 A;  2AEP A;  3UC1 A;  3V64 C;  4K1J A;  4FOW A;  2Z32 A;  2IAW A;  2ISM A;  5EO8 A;  3NO0 A;  4GJT A;  3GVL A;  2XZK A;  4GDJ A;  2HQS A;  5M1Z A;  4XMA A;  1MS4 A;  4IFN X;  5FNT A;  4FZH A;  2ZB5 A;  4L7B A;  3WDZ A;  4MWX A;  2VPJ A;  4FPK A;  1IUC A;  4HHO A;  2W8B B;  4XJ9 A;  3NN9 A;  1WCQ A;  1CVM A;  4GZW A;  1E8V A;  1Z4X A;  3GVJ A;  3PJQ A;  4B7M A;  1XOG A;  4R40 A;  4GEZ A;  4XJQ A;  3LI5 A;  3SAN A;  4XJU A;  2IAS A;  5FNQ A;  3K39 A;  4GNC A;  1H6L A;  2HT5 A;  4WA3 A;  3KGG A;  5HX0 A; 
#chains in the Genus database with same CATH homology
 3WN7 A;  1ZGK A;  4IFN X;  5FNT A;  1X2J A;  5CGJ A;  4L7B A;  4ZY3 A;  2ZZK A;  3WDZ A;  3ZGD A;  3ZGC A;  5FNS A;  2VPJ A;  1U6D X;  2FLU X;  2WOZ A;  2ZWA A;  4IFL X;  4IN4 A;  3II7 A;  3VNG A;  4IQK A;  5FZN A;  4L7C A;  2DYH A;  4N1B A;  5F72 C;  5FNR A;  4ZGC A;  5FZJ A;  4YY8 A;  4IFJ A;  4XMB A;  1X2R A;  4ASC A;  4L7D A;  5FNQ A;  5FNU A;  2XN4 A;  2Z32 A;  2ZW9 A;  4CH9 A;  3ADE A;  4CHB A;  3VNH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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