5FNTA

Structure of the keap1 kelch domain in complex with a small molecule inhibitor.
Total Genus 72
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
72
sequence length
289
structure length
289
Chain Sequence
GRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Mono-Acidic Inhibitors of the Kelch-Like Ech-Associated Protein 1 : Nuclear Factor Erythroid 2-Related Factor 2 (Keap1:Nrf2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
pubmed doi rcsb
molecule keywords KELCH-LIKE ECH-ASSOCIATED PROTEIN 1
molecule tags Transcription
source organism Mus musculus
total genus 72
structure length 289
sequence length 289
ec nomenclature
pdb deposition date 2015-11-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 5fntA00
4ASCA 2ZWAA 1X2RA 3II7A 5FNRA 5FZNA 3VNGA 4YY8A 4N1BA 1X2JA 4L7DA 3VNHA 3ZGDA 3WN7A 5F72C 2ZZKA 4L7BA 4L7CA 5FZJA 2VPJA 3ADEA 2ZW9A 4IFNX 3WDZA 2XN4A 4CHBA 4ZGCA 5CGJA 4IQKA 4CH9A 2Z32A 5FNQA 1ZGKA 3ZGCA 4ZY3A 2DYHA 2FLUX 1U6DX 4IFLX 2WOZA 4IN4A 5FNTA 5FNUA 4XMBA 5FNSA 4IFJA
chains in the Genus database with same CATH superfamily
1WCSA 4YY8A 2VW0A 4L7DA 4O5TA 4FOVA 1W20A 1N6DA 2OJHA 4GDJA 2F0ZA 4NC5A 1F8EA 2VPJA 2YA8A 4IYGA 1F8CA 4GZXA 2QE8A 3S8VA 3WDZA 1Z50A 5M1ZA 3H6JA 1NNBA 3V64C 1C5KA 3D11A 1N1TA 5D9CA 2QWGA 4GNCA 4CPYA 1SO7A 2QWJA 1W0PA 3PJQA 2ZWAA 1S18A 5FZNA 4A0PA 2GVUA 4FPGA 4FPKA 1IVBA 4FOQA 1XOEA 2BERA 4NN9A 4MWQA 4L7CA 1E8TA 4DG6A 1IVCA 3CYEA 4MX0A 1Z4VA 2IVZA 3TI4A 2C4LA 4YZ1A 4WEFA 4B7QA 4X4AA 4IFLX 4WA4A 1IUBA 3BEQA 3B7EA 4MZEA 4UF7A 4XIOA 3Q6PA 3II7A 1V0ZA 4FOYA 4MWRA 3BYCA 4ZLRA 1C9UA 2AGSA 2GHSA 3TI6A 3ALXA 1CRZA 1L7FA 3S8ZA 1MS5A 2AEQA 4M4NA 3TICA 4IFNX 2HQSA 3T1EA 2YA4A 1S0IA 4CPNA 2QWAA 4YW5A 4HW6A 1ZGKA 4FQ4A 4HZYA 2W8BA 2YA6A 1NCBN 2H2NA 2HU0A 2RKCA 5EX7A 4Q1UA 2F12A 5FNSA 1EUTA 1USRA 5B2CA 4D52A 3HRPA 4C1YA 3VNGA 1X2JA 4SLIA 3SALA 1IJQA 1L7HA 1QLGA 2POOA 3A9GA 4IMBA 3SLIA 4XJAA 2HT5A 4CPLA 1F8BA 7NN9A 4XJ9A 1NNCA 4YZ2A 2F24A 4ZGCA 5CGJA 2VW2A 1SNTA 1INHA 3S94A 1B9TA 5FNQA 4DGRA 4MWLA 1MS0A 2F25A 4D4UA 4HZWA 1E8VA 4GNAA 4MWUA 1DILA 2QWHA 5HUNA 4XMAA 4N1BA 3W09A 2W38A 3SRGA 1WP5A 2BZDA 3SILA 3V65B 3KGGA 2QWCA 3A72A 4FPCA 4YW4A 5HUMA 4CH9A 1V3BA 4AHAA 5HUGA 3INBA 5HX0A 1EUUA 3B69A 2WOZA 3FW0A 4IFJA 4MWVA 4GNBA 3TI8A 5FNRA 2HU4A 4XYXA 1INGA 2G8SA 1W8OA 1Z4XA 3NN9A 1MZ5A 4XILA 4BBWA 2JKBA 1OFZA 3H71A 1V04A 3WW9A 4FPHA 2F11A 2SILA 4KS2A 3ZGCA 4AGIA 2V91A 2W20A 4JF7A 5FNTA 2DSOA 3LI3A 3KYAA 4XOGA 3U0SA 4GZWA 4QN6A 5GTQA 4FPJA 2QWKA 1A14N 4XJQA 2SLIA 5GX3A 3K37A 4M3MA 4GZPA 2F13A 4L7BA 4WEGA 2YA5A 4FPFA 4GZSA 4M4UA 3ADEA 4JMLA 4G3NA 4CPOA 2AEPA 3NO0A 1IVDA 2IAXA 4MWWA 1N7DA 2VSMA 2FHRA 4KS4A 4MWXA 1W21A 3D12A 2BATA 4HIZA 1W8NA 2FP9A 5GX2A 2HT7A 1NMAN 4HZXA 4FPYA 2VAQA 4YW3A 1L7GA 1PJXA 2X9MA 4QNPA 3S2KA 4KS3A 5NN9A 1IVEA 4FPLA 1BJIA 2IAWA 3VNHA 1NN2A 2ZZKA 1INFA 1Z4WA 1XOGA 4YW1A 2VK7A 2ZB5A 5GX5A 4UOUA 2HTRA 2HT8A 1VCJA 4FZHA 2BF6A 4IQKA 3DASA 3K36A 1B9SA 3G4EA 1F8DA 1V0FA 1MWEA 4ZY3A 1N6FA 2VSKA 4GZOA 1NMCA 3SOQA 3GVLA 3H72A 1N6EA 1VCUA 2HTUA 2QWEA 3LI4A 4MJUA 1E8UA 4HZVA 1SUUA 3CL2A 3G4HA 3NSSA 2XCYA 2IAUA 3Q6KA 5HUKA 4FPOB 4H53A 4YW2A 3V1SA 2IATA 3AMRA 4XHBA 1INVA 2HTWA 2ISMA 4B7MA 4QN4A 3SREA 3K38A 2A75A 1K32A 2P4OA 4FPEA 2FLUX 3O9KA 4XMBA 1MZ6A 4X47A 3TIAA 3IAXA 2IARA 2F10A 4J9TA 1USXA 4HHQA 4XJUA 4B7JA 4XJRA 2DG0A 3I1CA 1KITA 4HZZA 1IUCA 1N1YA 1WCQA 4QN7A 2XZIA 3GVJA 4K1IA 1INWA 4X49A 2QWFA 1NPEA 1U6DX 2VK5A 4HHOA 5H47A 4XE9A 2HTQA 4CPZA 4KS1A 1N1SA 4FJ6A 4WA3A 2IAVA 2CMLA 1B9VA 4YZ5A 1RWLA 1SLLA 1S1DA 1Z4ZA 3TIBA 4WA5A 3JU4A 1INXA 5D9DA 3CKZA 4K1KA 2Z32A 2FP8A 4B7NA 4GB1A 1W0OA 2XZKA 4I00A 4XMIA 4NCSA 1DIMA 1IVGA 3DR2A 1V3CA 3TC9A 2IASA 4GJTA 4MWJA 4D52C 5B2DA 5F72C 2VVZA 4MZAA 4O5SA 1CRUA 1CVMA 2QWIA 2C4AA 1IVFA 4GN7A 2YDPA 2DG1A 1RWIA 2IAOA 4CSDA 1A4GA 4XJZA 1NCAN 2YA7A 3TI5A 2XZJA 3WWAA 4B7RA 2DYHA 1V3DA 5FNUA 2F28A 1NSBA 3O9JA 1V0EA 4GEZA 1X2RA 3HLHA 3AMSA 1N1VA 4KS5A 3ZGDA 3A71A 3WN7A 5JYYA 4CPMA 5FZJA 4QN3A 3A9HA 2GVWA 1Z4YA 1MS1A 2ZW9A 4X6KA 2F29A 4K1HA 3HLIA 2HTYA 2VWDA 3H73A 1CQ1A 1QBIA 2GVXA 1NCDN 1ZI0A 2SIMA 3ALWA 2FPBA 2QWDA 5GX4A 1MS4A 4MC7A 3OPZA 4GN8A 4M4VA 4MWYA 3Q6TA 2VK6A 2VW1A 2F26A 3GVKA 1V2IA 2IAQA 1SLIA 3UC1A 4R40A 2XN4A 4CHBA 2B8HA 4K3YA 5EO7A 6NN9A 2W5OA 1MS9A 3SOBB 4AGTA 3TI3A 1V3EA 1POOA 2HTVA 4Q6KA 1MS3A 3K39A 4YZ3A 1NSDA 1NCCN 5FWWA 2W8BB 1H6LA 4ASCA 4GZTA 1INYA 5F9TA 3SANA 5D9BA 3FVZA 5GX1A 4GDIA 4D52B 4GZQA 4C1YB 1W1XA 2ZB6A 2QWBA 4FP3A 4K1JA 1Q7FA 4FP2A 4FOWA 3L6VA 3LI5A 4YZ4A 4MJVA 4AH4A 4D8SA 3E5ZA 4GN9A 2W5NA 1NNAA 4IN4A 2IAPA 4QN5A 5EO8A 1A4QA 2FPCA 4FVKA 3CL0A 4PWZA 1E1AA 2GVVA 1MR5A 1NMBN 4XIKA 4XHXA 2F27A 4H52A 2AH2A 4XJ8A 2H2UA 3SOVA 3P5BL 3O4PA 1S0JA 4XJWA 1NSCA 1EUSA 1MS8A 1EURA 2YDTA 3K3AA
chains in the Genus database with same CATH topology
4ASCA 2ZWAA 1X2RA 3II7A 5FNRA 5FZNA 3VNGA 4YY8A 4N1BA 1X2JA 4L7DA 3VNHA 3ZGDA 3WN7A 5F72C 2ZZKA 4L7BA 4L7CA 5FZJA 2VPJA 3ADEA 2ZW9A 4IFNX 3WDZA 2XN4A 4CHBA 4ZGCA 5CGJA 4IQKA 4CH9A 2Z32A 5FNQA 1ZGKA 3ZGCA 4ZY3A 2DYHA 2FLUX 1U6DX 4IFLX 2WOZA 4IN4A 5FNTA 5FNUA 4XMBA 5FNSA 4IFJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ASC A;  2ZWA A;  1X2R A;  3II7 A;  5FNR A;  5FZN A;  3VNG A;  4YY8 A;  4N1B A;  1X2J A;  4L7D A;  3VNH A;  3ZGD A;  3WN7 A;  5F72 C;  2ZZK A;  4L7B A;  4L7C A;  5FZJ A;  2VPJ A;  3ADE A;  2ZW9 A;  4IFN X;  3WDZ A;  2XN4 A;  4CHB A;  4ZGC A;  5CGJ A;  4IQK A;  4CH9 A;  2Z32 A;  5FNQ A;  1ZGK A;  3ZGC A;  4ZY3 A;  2DYH A;  2FLU X;  1U6D X;  4IFL X;  2WOZ A;  4IN4 A;  5FNT A;  5FNU A;  4XMB A;  5FNS A;  4IFJ A; 
#chains in the Genus database with same CATH topology
 1WCS A;  4YY8 A;  2VW0 A;  4L7D A;  4O5T A;  4FOV A;  1W20 A;  1N6D A;  2OJH A;  4GDJ A;  2F0Z A;  4NC5 A;  1F8E A;  2VPJ A;  2YA8 A;  4IYG A;  1F8C A;  4GZX A;  2QE8 A;  3S8V A;  3WDZ A;  1Z50 A;  5M1Z A;  3H6J A;  1NNB A;  3V64 C;  1C5K A;  3D11 A;  1N1T A;  5D9C A;  2QWG A;  4GNC A;  4CPY A;  1SO7 A;  2QWJ A;  1W0P A;  3PJQ A;  2ZWA A;  1S18 A;  5FZN A;  4A0P A;  2GVU A;  4FPG A;  4FPK A;  1IVB A;  4FOQ A;  1XOE A;  2BER A;  4NN9 A;  4MWQ A;  4L7C A;  1E8T A;  4DG6 A;  1IVC A;  3CYE A;  4MX0 A;  1Z4V A;  2IVZ A;  3TI4 A;  2C4L A;  4YZ1 A;  4WEF A;  4B7Q A;  4X4A A;  4IFL X;  4WA4 A;  1IUB A;  3BEQ A;  3B7E A;  4MZE A;  4UF7 A;  4XIO A;  3Q6P A;  3II7 A;  1V0Z A;  4FOY A;  4MWR A;  3BYC A;  4ZLR A;  1C9U A;  2AGS A;  2GHS A;  3TI6 A;  3ALX A;  1CRZ A;  1L7F A;  3S8Z A;  1MS5 A;  2AEQ A;  4M4N A;  3TIC A;  4IFN X;  2HQS A;  3T1E A;  2YA4 A;  1S0I A;  4CPN A;  2QWA A;  4YW5 A;  4HW6 A;  1ZGK A;  4FQ4 A;  4HZY A;  2W8B A;  2YA6 A;  1NCB N;  2H2N A;  2HU0 A;  2RKC A;  5EX7 A;  4Q1U A;  2F12 A;  5FNS A;  1EUT A;  1USR A;  5B2C A;  4D52 A;  3HRP A;  4C1Y A;  3VNG A;  1X2J A;  4SLI A;  3SAL A;  1IJQ A;  1L7H A;  1QLG A;  2POO A;  3A9G A;  4IMB A;  3SLI A;  4XJA A;  2HT5 A;  4CPL A;  1F8B A;  7NN9 A;  4XJ9 A;  1NNC A;  4YZ2 A;  2F24 A;  4ZGC A;  5CGJ A;  2VW2 A;  1SNT A;  1INH A;  3S94 A;  1B9T A;  5FNQ A;  4DGR A;  4MWL A;  1MS0 A;  2F25 A;  4D4U A;  4HZW A;  1E8V A;  4GNA A;  4MWU A;  1DIL A;  2QWH A;  5HUN A;  4XMA A;  4N1B A;  3W09 A;  2W38 A;  3SRG A;  1WP5 A;  2BZD A;  3SIL A;  3V65 B;  3KGG A;  2QWC A;  3A72 A;  4FPC A;  4YW4 A;  5HUM A;  4CH9 A;  1V3B A;  4AHA A;  5HUG A;  3INB A;  5HX0 A;  1EUU A;  3B69 A;  2WOZ A;  3FW0 A;  4IFJ A;  4MWV A;  4GNB A;  3TI8 A;  5FNR A;  2HU4 A;  4XYX A;  1ING A;  2G8S A;  1W8O A;  1Z4X A;  3NN9 A;  1MZ5 A;  4XIL A;  4BBW A;  2JKB A;  1OFZ A;  3H71 A;  1V04 A;  3WW9 A;  4FPH A;  2F11 A;  2SIL A;  4KS2 A;  3ZGC A;  4AGI A;  2V91 A;  2W20 A;  4JF7 A;  5FNT A;  2DSO A;  3LI3 A;  3KYA A;  4XOG A;  3U0S A;  4GZW A;  4QN6 A;  5GTQ A;  4FPJ A;  2QWK A;  1A14 N;  4XJQ A;  2SLI A;  5GX3 A;  3K37 A;  4M3M A;  4GZP A;  2F13 A;  4L7B A;  4WEG A;  2YA5 A;  4FPF A;  4GZS A;  4M4U A;  3ADE A;  4JML A;  4G3N A;  4CPO A;  2AEP A;  3NO0 A;  1IVD A;  2IAX A;  4MWW A;  1N7D A;  2VSM A;  2FHR A;  4KS4 A;  4MWX A;  1W21 A;  3D12 A;  2BAT A;  4HIZ A;  1W8N A;  2FP9 A;  5GX2 A;  2HT7 A;  1NMA N;  4HZX A;  4FPY A;  2VAQ A;  4YW3 A;  1L7G A;  1PJX A;  2X9M A;  4QNP A;  3S2K A;  4KS3 A;  5NN9 A;  1IVE A;  4FPL A;  1BJI A;  2IAW A;  3VNH A;  1NN2 A;  2ZZK A;  1INF A;  1Z4W A;  1XOG A;  4YW1 A;  2VK7 A;  2ZB5 A;  5GX5 A;  4UOU A;  2HTR A;  2HT8 A;  1VCJ A;  4FZH A;  2BF6 A;  4IQK A;  3DAS A;  3K36 A;  1B9S A;  3G4E A;  1F8D A;  1V0F A;  1MWE A;  4ZY3 A;  1N6F A;  2VSK A;  4GZO A;  1NMC A;  3SOQ A;  3GVL A;  3H72 A;  1N6E A;  1VCU A;  2HTU A;  2QWE A;  3LI4 A;  4MJU A;  1E8U A;  4HZV A;  1SUU A;  3CL2 A;  3G4H A;  3NSS A;  2XCY A;  2IAU A;  3Q6K A;  5HUK A;  4FPO B;  4H53 A;  4YW2 A;  3V1S A;  2IAT A;  3AMR A;  4XHB A;  1INV A;  2HTW A;  2ISM A;  4B7M A;  4QN4 A;  3SRE A;  3K38 A;  2A75 A;  1K32 A;  2P4O A;  4FPE A;  2FLU X;  3O9K A;  4XMB A;  1MZ6 A;  4X47 A;  3TIA A;  3IAX A;  2IAR A;  2F10 A;  4J9T A;  1USX A;  4HHQ A;  4XJU A;  4B7J A;  4XJR A;  2DG0 A;  3I1C A;  1KIT A;  4HZZ A;  1IUC A;  1N1Y A;  1WCQ A;  4QN7 A;  2XZI A;  3GVJ A;  4K1I A;  1INW A;  4X49 A;  2QWF A;  1NPE A;  1U6D X;  2VK5 A;  4HHO A;  5H47 A;  4XE9 A;  2HTQ A;  4CPZ A;  4KS1 A;  1N1S A;  4FJ6 A;  4WA3 A;  2IAV A;  2CML A;  1B9V A;  4YZ5 A;  1RWL A;  1SLL A;  1S1D A;  1Z4Z A;  3TIB A;  4WA5 A;  3JU4 A;  1INX A;  5D9D A;  3CKZ A;  4K1K A;  2Z32 A;  2FP8 A;  4B7N A;  4GB1 A;  1W0O A;  2XZK A;  4I00 A;  4XMI A;  4NCS A;  1DIM A;  1IVG A;  3DR2 A;  1V3C A;  3TC9 A;  2IAS A;  4GJT A;  4MWJ A;  4D52 C;  5B2D A;  5F72 C;  2VVZ A;  4MZA A;  4O5S A;  1CRU A;  1CVM A;  2QWI A;  2C4A A;  1IVF A;  4GN7 A;  2YDP A;  2DG1 A;  1RWI A;  2IAO A;  4CSD A;  1A4G A;  4XJZ A;  1NCA N;  2YA7 A;  3TI5 A;  2XZJ A;  3WWA A;  4B7R A;  2DYH A;  1V3D A;  5FNU A;  2F28 A;  1NSB A;  3O9J A;  1V0E A;  4GEZ A;  1X2R A;  3HLH A;  3AMS A;  1N1V A;  4KS5 A;  3ZGD A;  3A71 A;  3WN7 A;  5JYY A;  4CPM A;  5FZJ A;  4QN3 A;  3A9H A;  2GVW A;  1Z4Y A;  1MS1 A;  2ZW9 A;  4X6K A;  2F29 A;  4K1H A;  3HLI A;  2HTY A;  2VWD A;  3H73 A;  1CQ1 A;  1QBI A;  2GVX A;  1NCD N;  1ZI0 A;  2SIM A;  3ALW A;  2FPB A;  2QWD A;  5GX4 A;  1MS4 A;  4MC7 A;  3OPZ A;  4GN8 A;  4M4V A;  4MWY A;  3Q6T A;  2VK6 A;  2VW1 A;  2F26 A;  3GVK A;  1V2I A;  2IAQ A;  1SLI A;  3UC1 A;  4R40 A;  2XN4 A;  4CHB A;  2B8H A;  4K3Y A;  5EO7 A;  6NN9 A;  2W5O A;  1MS9 A;  3SOB B;  4AGT A;  3TI3 A;  1V3E A;  1POO A;  2HTV A;  4Q6K A;  1MS3 A;  3K39 A;  4YZ3 A;  1NSD A;  1NCC N;  5FWW A;  2W8B B;  1H6L A;  4ASC A;  4GZT A;  1INY A;  5F9T A;  3SAN A;  5D9B A;  3FVZ A;  5GX1 A;  4GDI A;  4D52 B;  4GZQ A;  4C1Y B;  1W1X A;  2ZB6 A;  2QWB A;  4FP3 A;  4K1J A;  1Q7F A;  4FP2 A;  4FOW A;  3L6V A;  3LI5 A;  4YZ4 A;  4MJV A;  4AH4 A;  4D8S A;  3E5Z A;  4GN9 A;  2W5N A;  1NNA A;  4IN4 A;  2IAP A;  4QN5 A;  5EO8 A;  1A4Q A;  2FPC A;  4FVK A;  3CL0 A;  4PWZ A;  1E1A A;  2GVV A;  1MR5 A;  1NMB N;  4XIK A;  4XHX A;  2F27 A;  4H52 A;  2AH2 A;  4XJ8 A;  2H2U A;  3SOV A;  3P5B L;  3O4P A;  1S0J A;  4XJW A;  1NSC A;  1EUS A;  1MS8 A;  1EUR A;  2YDT A;  3K3A A; 
#chains in the Genus database with same CATH homology
 4ASC A;  2ZWA A;  1X2R A;  3II7 A;  5FNR A;  5FZN A;  3VNG A;  4YY8 A;  4N1B A;  1X2J A;  4L7D A;  3VNH A;  3ZGD A;  3WN7 A;  5F72 C;  2ZZK A;  4L7B A;  4L7C A;  5FZJ A;  2VPJ A;  3ADE A;  2ZW9 A;  4IFN X;  3WDZ A;  2XN4 A;  4CHB A;  4ZGC A;  5CGJ A;  4IQK A;  4CH9 A;  2Z32 A;  5FNQ A;  1ZGK A;  3ZGC A;  4ZY3 A;  2DYH A;  2FLU X;  1U6D X;  4IFL X;  2WOZ A;  4IN4 A;  5FNT A;  5FNU A;  4XMB A;  5FNS A;  4IFJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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