5FNTA

Structure of the keap1 kelch domain in complex with a small molecule inhibitor.
Total Genus 72
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
72
sequence length
289
structure length
289
Chain Sequence
GRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Mono-Acidic Inhibitors of the Kelch-Like Ech-Associated Protein 1 : Nuclear Factor Erythroid 2-Related Factor 2 (Keap1:Nrf2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
pubmed doi rcsb
molecule keywords KELCH-LIKE ECH-ASSOCIATED PROTEIN 1
molecule tags Transcription
source organism Mus musculus
total genus 72
structure length 289
sequence length 289
ec nomenclature
pdb deposition date 2015-11-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 5fntA00
4IFLX 1X2JA 5FNRA 1X2RA 3WN7A 4ZY3A 1ZGKA 4L7DA 4IFJA 2ZW9A 2Z32A 5FNUA 5F72C 4IFNX 3WDZA 3ZGDA 4XMBA 3ZGCA 1U6DX 4CHBA 2WOZA 5FZJA 4YY8A 2FLUX 2XN4A 4L7BA 2ZZKA 4N1BA 2ZWAA 4L7CA 5FNTA 5FNQA 4ZGCA 4IN4A 4ASCA 5CGJA 5FZNA 3VNHA 3ADEA 3VNGA 5FNSA 2VPJA 4CH9A 2DYHA 4IQKA 3II7A
chains in the Genus database with same CATH superfamily
4IFLX 4XMAA 2QWJA 3TICA 4FOYA 1SNTA 1B9VA 1N1VA 2FP9A 4FOQA 4MWUA 1V0EA 4FPJA 2WOZA 5EX7A 5NN9A 1V04A 3FW0A 4K1JA 4K1IA 1E8VA 4YW4A 3LI4A 2VW2A 4Q1UA 2XZIA 4BBWA 1CVMA 4GN8A 4CH9A 1NNCA 4K3YA 1NPEA 5HUKA 3CKZA 3TI5A 1Z4WA 4MC7A 2VW0A 2F25A 4MWJA 2BATA 4FPOB 1SO7A 2YA7A 3SREA 3UC1A 2HTRA 4L7DA 2ZW9A 2HQSA 1V3CA 2YA5A 3H73A 4GDIA 4GZTA 1IVFA 1E1AA 3K3AA 4WA5A 4DG6A 2DSOA 1NCCN 2HT5A 2IAVA 1S1DA 4X49A 4FPCA 5GX5A 4M4VA 4XJRA 4SLIA 3NN9A 2FP8A 5GTQA 3II7A 2F13A 4GJTA 4AHAA 4D8SA 5JYYA 1MZ5A 1USXA 2QWAA 2FHRA 3DASA 3NSSA 1SLIA 4KS1A 2HT7A 4XJWA 4XJQA 3ZGCA 3LI5A 4X47A 2F24A 4C1YB 3BYCA 2QWDA 4KS3A 2QWKA 3TIAA 2W8BB 1H6LA 3SLIA 4FPGA 3O4PA 5HUNA 4MWWA 3SRGA 3SALA 4X6KA 4CPOA 1B9TA 1DIMA 2HT8A 4B7MA 4QNPA 3O9JA 1PJXA 4GN7A 4D4UA 1A4GA 1NNAA 3E5ZA 5HX0A 1N6DA 2W5NA 1W20A 1CRZA 4MWVA 2AGSA 2VSMA 3S94A 4YZ5A 4N1BA 4XJ9A 4HIZA 2IAWA 1IVBA 4O5SA 1N7DA 2IASA 3TI3A 5EO7A 4IMBA 5F9TA 1WCSA 3LI3A 2QWFA 4CPYA 2Z32A 4IFNX 2GVXA 3S8ZA 2VK7A 1U6DX 4YZ3A 4GZPA 2W5OA 4KS2A 2JKBA 3TI6A 4L7BA 3TIBA 3SILA 4XMIA 3GVLA 1INGA 1C9UA 5D9CA 1W0OA 3DR2A 2F26A 4FPEA 4FVKA 2P4OA 4YZ2A 1L7HA 1EUUA 3V1SA 4GEZA 3Q6PA 5FZJA 2GVUA 4D52B 1ZGKA 2F12A 2VK5A 1NNBA 1EUTA 1MS1A 1S0JA 3HLHA 4FOVA 1NSBA 5GX2A 7NN9A 2FPBA 2ZWAA 3Q6KA 4JF7A 4XHBA 1WP5A 1S0IA 4H52A 1F8BA 4AH4A 4CPNA 4NC5A 4PWZA 2HTYA 3V65B 3WW9A 1MS9A 1X2JA 2IAQA 3S8VA 4MWQA 2G8SA 3OPZA 2F28A 4HHOA 5FNUA 1L7FA 4FPYA 3SANA 1MR5A 2VVZA 4MWXA 1INYA 1Z4ZA 2BERA 2SLIA 2W38A 2ZZKA 3G4HA 4MWLA 4I00A 1ZI0A 1W8NA 5FNTA 4GNCA 6NN9A 2QWGA 3KGGA 4GZSA 3A9HA 3TC9A 2SIMA 4QN4A 4XOGA 2OJHA 3HRPA 1XOEA 3D12A 1NMCA 4FP3A 1SUUA 3W09A 2QWEA 1INXA 2YDTA 3JU4A 4B7JA 3S2KA 2F29A 4QN5A 4XIKA 4HHQA 4GZQA 1IUBA 4M4UA 1W1XA 4CPZA 4WEFA 2IARA 3K39A 3U0SA 1V3BA 1K32A 2F10A 4KS5A 2HTVA 4ASCA 1C5KA 4C1YA 1MS4A 1W21A 3CYEA 3WWAA 3SOBB 4WEGA 1INHA 4WA3A 2C4AA 1E8TA 2W8BA 5EO8A 4G3NA 5FNRA 1V2IA 4FJ6A 2C4LA 4FPKA 3WDZA 4Q6KA 4FOWA 3GVJA 5B2DA 4UF7A 3H6JA 3H72A 1N6EA 2QWIA 4ZGCA 2AEPA 4XJAA 1IVDA 4YW2A 2F11A 2VK6A 3VNHA 2YA6A 1S18A 2BZDA 4GNAA 3ALXA 4XILA 1A4QA 5FWWA 1NCDN 4FZHA 4XJUA 4M4NA 3AMSA 2VWDA 4D52C 3ZGDA 3K37A 2CMLA 4KS4A 2FPCA 4GDJA 4XMBA 4YW5A 1QBIA 2RKCA 4FQ4A 4FPFA 4FP2A 4M3MA 4QN3A 1RWIA 2YA4A 2ZB6A 1V3DA 2HU4A 2IAPA 2VAQA 3ADEA 2DG1A 4MX0A 4XJ8A 4GN9A 4FPHA 1W8OA 5FNSA 2VPJA 3KYAA 2DYHA 1QLGA 4J9TA 3B69A 1V0FA 4GZWA 1VCUA 2XZKA 1F8DA 3WN7A 2X9MA 1EURA 1IJQA 4XE9A 1NMBN 4D52A 2B8HA 4DGRA 5H47A 5FNQA 3B7EA 1NSDA 2VSKA 3CL0A 3K36A 2HTWA 4HZWA 5GX4A 2AH2A 4AGIA 4X4AA 2GHSA 3AMRA 3IAXA 2IAUA 3D11A 3GVKA 1IVCA 3TI4A 3H71A 4HZZA 2XN4A 2QWHA 2H2NA 1POOA 1INVA 4AGTA 1IVGA 3A9GA 3SOQA 3A72A 3NO0A 2V91A 1IUCA 3A71A 1Q7FA 1W0PA 2A75A 4QN7A 1CQ1A 1B9SA 1N1YA 4MWRA 2HTUA 4NN9A 4ZY3A 4YW3A 1NN2A 1E8UA 4IFJA 2IATA 3I1CA 1N6FA 3G4EA 3ALWA 4GB1A 4GNBA 1MS3A 1V0ZA 5B2CA 2FLUX 1INFA 4ZLRA 1IVEA 1NCAN 3PJQA 1A14N 5CGJA 2F27A 1F8CA 4GZXA 3FVZA 4A0PA 5HUGA 1MZ6A 4GZOA 4K1KA 4MWYA 5D9DA 4MJUA 3TI8A 1Z50A 4CSDA 1MS8A 1X2RA 2HTQA 4XJZA 1MS5A 5F72C 4CPLA 4IYGA 1F8EA 2IAOA 4JMLA 1DILA 2HU0A 4XHXA 1INWA 4YY8A 3P5BL 4YZ1A 1RWLA 4L7CA 1USRA 4XYXA 2F0ZA 4YZ4A 1N1SA 2QE8A 3T1EA 4IQKA 2BF6A 4K1HA 1BJIA 4MZAA 3HLIA 1SLLA 3CL2A 2GVWA 4HZXA 4B7RA 1NCBN 1NMAN 2QWCA 2VW1A 2XZJA 3BEQA 1XOGA 1Z4YA 3V64C 2DG0A 2GVVA 1WCQA 2ZB5A 4XIOA 1EUSA 4WA4A 2H2UA 2AEQA 1L7GA 3VNGA 4H53A 1VCJA 3L6VA 2YA8A 3SOVA 5D9BA 4MJVA 4HZYA 1CRUA 4YW1A 5GX1A 1MS0A 1NSCA 1KITA 5HUMA 2YDPA 1Z4VA 4R40A 3K38A 2POOA 4QN6A 3INBA 1OFZA 2XCYA 4CHBA 3Q6TA 1MWEA 3O9KA 5M1ZA 1N1TA 2ISMA 2QWBA 4B7NA 5GX3A 4B7QA 4O5TA 4IN4A 1V3EA 1Z4XA 5FZNA 4MZEA 4HZVA 2IVZA 4NCSA 4FPLA 4CPMA 2SILA 2W20A 4HW6A 4UOUA 2IAXA
chains in the Genus database with same CATH topology
4IFLX 1X2JA 5FNRA 1X2RA 3WN7A 4ZY3A 1ZGKA 4L7DA 4IFJA 2ZW9A 2Z32A 5FNUA 5F72C 4IFNX 3WDZA 3ZGDA 4XMBA 3ZGCA 1U6DX 4CHBA 2WOZA 5FZJA 4YY8A 2FLUX 2XN4A 4L7BA 2ZZKA 4N1BA 2ZWAA 4L7CA 5FNTA 5FNQA 4ZGCA 4IN4A 4ASCA 5CGJA 5FZNA 3VNHA 3ADEA 3VNGA 5FNSA 2VPJA 4CH9A 2DYHA 4IQKA 3II7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IFL X;  1X2J A;  5FNR A;  1X2R A;  3WN7 A;  4ZY3 A;  1ZGK A;  4L7D A;  4IFJ A;  2ZW9 A;  2Z32 A;  5FNU A;  5F72 C;  4IFN X;  3WDZ A;  3ZGD A;  4XMB A;  3ZGC A;  1U6D X;  4CHB A;  2WOZ A;  5FZJ A;  4YY8 A;  2FLU X;  2XN4 A;  4L7B A;  2ZZK A;  4N1B A;  2ZWA A;  4L7C A;  5FNT A;  5FNQ A;  4ZGC A;  4IN4 A;  4ASC A;  5CGJ A;  5FZN A;  3VNH A;  3ADE A;  3VNG A;  5FNS A;  2VPJ A;  4CH9 A;  2DYH A;  4IQK A;  3II7 A; 
#chains in the Genus database with same CATH topology
 4IFL X;  4XMA A;  2QWJ A;  3TIC A;  4FOY A;  1SNT A;  1B9V A;  1N1V A;  2FP9 A;  4FOQ A;  4MWU A;  1V0E A;  4FPJ A;  2WOZ A;  5EX7 A;  5NN9 A;  1V04 A;  3FW0 A;  4K1J A;  4K1I A;  1E8V A;  4YW4 A;  3LI4 A;  2VW2 A;  4Q1U A;  2XZI A;  4BBW A;  1CVM A;  4GN8 A;  4CH9 A;  1NNC A;  4K3Y A;  1NPE A;  5HUK A;  3CKZ A;  3TI5 A;  1Z4W A;  4MC7 A;  2VW0 A;  2F25 A;  4MWJ A;  2BAT A;  4FPO B;  1SO7 A;  2YA7 A;  3SRE A;  3UC1 A;  2HTR A;  4L7D A;  2ZW9 A;  2HQS A;  1V3C A;  2YA5 A;  3H73 A;  4GDI A;  4GZT A;  1IVF A;  1E1A A;  3K3A A;  4WA5 A;  4DG6 A;  2DSO A;  1NCC N;  2HT5 A;  2IAV A;  1S1D A;  4X49 A;  4FPC A;  5GX5 A;  4M4V A;  4XJR A;  4SLI A;  3NN9 A;  2FP8 A;  5GTQ A;  3II7 A;  2F13 A;  4GJT A;  4AHA A;  4D8S A;  5JYY A;  1MZ5 A;  1USX A;  2QWA A;  2FHR A;  3DAS A;  3NSS A;  1SLI A;  4KS1 A;  2HT7 A;  4XJW A;  4XJQ A;  3ZGC A;  3LI5 A;  4X47 A;  2F24 A;  4C1Y B;  3BYC A;  2QWD A;  4KS3 A;  2QWK A;  3TIA A;  2W8B B;  1H6L A;  3SLI A;  4FPG A;  3O4P A;  5HUN A;  4MWW A;  3SRG A;  3SAL A;  4X6K A;  4CPO A;  1B9T A;  1DIM A;  2HT8 A;  4B7M A;  4QNP A;  3O9J A;  1PJX A;  4GN7 A;  4D4U A;  1A4G A;  1NNA A;  3E5Z A;  5HX0 A;  1N6D A;  2W5N A;  1W20 A;  1CRZ A;  4MWV A;  2AGS A;  2VSM A;  3S94 A;  4YZ5 A;  4N1B A;  4XJ9 A;  4HIZ A;  2IAW A;  1IVB A;  4O5S A;  1N7D A;  2IAS A;  3TI3 A;  5EO7 A;  4IMB A;  5F9T A;  1WCS A;  3LI3 A;  2QWF A;  4CPY A;  2Z32 A;  4IFN X;  2GVX A;  3S8Z A;  2VK7 A;  1U6D X;  4YZ3 A;  4GZP A;  2W5O A;  4KS2 A;  2JKB A;  3TI6 A;  4L7B A;  3TIB A;  3SIL A;  4XMI A;  3GVL A;  1ING A;  1C9U A;  5D9C A;  1W0O A;  3DR2 A;  2F26 A;  4FPE A;  4FVK A;  2P4O A;  4YZ2 A;  1L7H A;  1EUU A;  3V1S A;  4GEZ A;  3Q6P A;  5FZJ A;  2GVU A;  4D52 B;  1ZGK A;  2F12 A;  2VK5 A;  1NNB A;  1EUT A;  1MS1 A;  1S0J A;  3HLH A;  4FOV A;  1NSB A;  5GX2 A;  7NN9 A;  2FPB A;  2ZWA A;  3Q6K A;  4JF7 A;  4XHB A;  1WP5 A;  1S0I A;  4H52 A;  1F8B A;  4AH4 A;  4CPN A;  4NC5 A;  4PWZ A;  2HTY A;  3V65 B;  3WW9 A;  1MS9 A;  1X2J A;  2IAQ A;  3S8V A;  4MWQ A;  2G8S A;  3OPZ A;  2F28 A;  4HHO A;  5FNU A;  1L7F A;  4FPY A;  3SAN A;  1MR5 A;  2VVZ A;  4MWX A;  1INY A;  1Z4Z A;  2BER A;  2SLI A;  2W38 A;  2ZZK A;  3G4H A;  4MWL A;  4I00 A;  1ZI0 A;  1W8N A;  5FNT A;  4GNC A;  6NN9 A;  2QWG A;  3KGG A;  4GZS A;  3A9H A;  3TC9 A;  2SIM A;  4QN4 A;  4XOG A;  2OJH A;  3HRP A;  1XOE A;  3D12 A;  1NMC A;  4FP3 A;  1SUU A;  3W09 A;  2QWE A;  1INX A;  2YDT A;  3JU4 A;  4B7J A;  3S2K A;  2F29 A;  4QN5 A;  4XIK A;  4HHQ A;  4GZQ A;  1IUB A;  4M4U A;  1W1X A;  4CPZ A;  4WEF A;  2IAR A;  3K39 A;  3U0S A;  1V3B A;  1K32 A;  2F10 A;  4KS5 A;  2HTV A;  4ASC A;  1C5K A;  4C1Y A;  1MS4 A;  1W21 A;  3CYE A;  3WWA A;  3SOB B;  4WEG A;  1INH A;  4WA3 A;  2C4A A;  1E8T A;  2W8B A;  5EO8 A;  4G3N A;  5FNR A;  1V2I A;  4FJ6 A;  2C4L A;  4FPK A;  3WDZ A;  4Q6K A;  4FOW A;  3GVJ A;  5B2D A;  4UF7 A;  3H6J A;  3H72 A;  1N6E A;  2QWI A;  4ZGC A;  2AEP A;  4XJA A;  1IVD A;  4YW2 A;  2F11 A;  2VK6 A;  3VNH A;  2YA6 A;  1S18 A;  2BZD A;  4GNA A;  3ALX A;  4XIL A;  1A4Q A;  5FWW A;  1NCD N;  4FZH A;  4XJU A;  4M4N A;  3AMS A;  2VWD A;  4D52 C;  3ZGD A;  3K37 A;  2CML A;  4KS4 A;  2FPC A;  4GDJ A;  4XMB A;  4YW5 A;  1QBI A;  2RKC A;  4FQ4 A;  4FPF A;  4FP2 A;  4M3M A;  4QN3 A;  1RWI A;  2YA4 A;  2ZB6 A;  1V3D A;  2HU4 A;  2IAP A;  2VAQ A;  3ADE A;  2DG1 A;  4MX0 A;  4XJ8 A;  4GN9 A;  4FPH A;  1W8O A;  5FNS A;  2VPJ A;  3KYA A;  2DYH A;  1QLG A;  4J9T A;  3B69 A;  1V0F A;  4GZW A;  1VCU A;  2XZK A;  1F8D A;  3WN7 A;  2X9M A;  1EUR A;  1IJQ A;  4XE9 A;  1NMB N;  4D52 A;  2B8H A;  4DGR A;  5H47 A;  5FNQ A;  3B7E A;  1NSD A;  2VSK A;  3CL0 A;  3K36 A;  2HTW A;  4HZW A;  5GX4 A;  2AH2 A;  4AGI A;  4X4A A;  2GHS A;  3AMR A;  3IAX A;  2IAU A;  3D11 A;  3GVK A;  1IVC A;  3TI4 A;  3H71 A;  4HZZ A;  2XN4 A;  2QWH A;  2H2N A;  1POO A;  1INV A;  4AGT A;  1IVG A;  3A9G A;  3SOQ A;  3A72 A;  3NO0 A;  2V91 A;  1IUC A;  3A71 A;  1Q7F A;  1W0P A;  2A75 A;  4QN7 A;  1CQ1 A;  1B9S A;  1N1Y A;  4MWR A;  2HTU A;  4NN9 A;  4ZY3 A;  4YW3 A;  1NN2 A;  1E8U A;  4IFJ A;  2IAT A;  3I1C A;  1N6F A;  3G4E A;  3ALW A;  4GB1 A;  4GNB A;  1MS3 A;  1V0Z A;  5B2C A;  2FLU X;  1INF A;  4ZLR A;  1IVE A;  1NCA N;  3PJQ A;  1A14 N;  5CGJ A;  2F27 A;  1F8C A;  4GZX A;  3FVZ A;  4A0P A;  5HUG A;  1MZ6 A;  4GZO A;  4K1K A;  4MWY A;  5D9D A;  4MJU A;  3TI8 A;  1Z50 A;  4CSD A;  1MS8 A;  1X2R A;  2HTQ A;  4XJZ A;  1MS5 A;  5F72 C;  4CPL A;  4IYG A;  1F8E A;  2IAO A;  4JML A;  1DIL A;  2HU0 A;  4XHX A;  1INW A;  4YY8 A;  3P5B L;  4YZ1 A;  1RWL A;  4L7C A;  1USR A;  4XYX A;  2F0Z A;  4YZ4 A;  1N1S A;  2QE8 A;  3T1E A;  4IQK A;  2BF6 A;  4K1H A;  1BJI A;  4MZA A;  3HLI A;  1SLL A;  3CL2 A;  2GVW A;  4HZX A;  4B7R A;  1NCB N;  1NMA N;  2QWC A;  2VW1 A;  2XZJ A;  3BEQ A;  1XOG A;  1Z4Y A;  3V64 C;  2DG0 A;  2GVV A;  1WCQ A;  2ZB5 A;  4XIO A;  1EUS A;  4WA4 A;  2H2U A;  2AEQ A;  1L7G A;  3VNG A;  4H53 A;  1VCJ A;  3L6V A;  2YA8 A;  3SOV A;  5D9B A;  4MJV A;  4HZY A;  1CRU A;  4YW1 A;  5GX1 A;  1MS0 A;  1NSC A;  1KIT A;  5HUM A;  2YDP A;  1Z4V A;  4R40 A;  3K38 A;  2POO A;  4QN6 A;  3INB A;  1OFZ A;  2XCY A;  4CHB A;  3Q6T A;  1MWE A;  3O9K A;  5M1Z A;  1N1T A;  2ISM A;  2QWB A;  4B7N A;  5GX3 A;  4B7Q A;  4O5T A;  4IN4 A;  1V3E A;  1Z4X A;  5FZN A;  4MZE A;  4HZV A;  2IVZ A;  4NCS A;  4FPL A;  4CPM A;  2SIL A;  2W20 A;  4HW6 A;  4UOU A;  2IAX A; 
#chains in the Genus database with same CATH homology
 4IFL X;  1X2J A;  5FNR A;  1X2R A;  3WN7 A;  4ZY3 A;  1ZGK A;  4L7D A;  4IFJ A;  2ZW9 A;  2Z32 A;  5FNU A;  5F72 C;  4IFN X;  3WDZ A;  3ZGD A;  4XMB A;  3ZGC A;  1U6D X;  4CHB A;  2WOZ A;  5FZJ A;  4YY8 A;  2FLU X;  2XN4 A;  4L7B A;  2ZZK A;  4N1B A;  2ZWA A;  4L7C A;  5FNT A;  5FNQ A;  4ZGC A;  4IN4 A;  4ASC A;  5CGJ A;  5FZN A;  3VNH A;  3ADE A;  3VNG A;  5FNS A;  2VPJ A;  4CH9 A;  2DYH A;  4IQK A;  3II7 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...