5FNUA

Structure of the keap1 kelch domain in complex with a small molecule inhibitor.
Total Genus 74
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
74
sequence length
288
structure length
288
Chain Sequence
RLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transcription
molecule keywords KELCH-LIKE ECH-ASSOCIATED PROTEIN 1
publication title Mono-Acidic Inhibitors of the Kelch-Like Ech-Associated Protein 1 : Nuclear Factor Erythroid 2-Related Factor 2 (Keap1:Nrf2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
pubmed doi rcsb
source organism Mus musculus
total genus 74
structure length 288
sequence length 288
ec nomenclature
pdb deposition date 2015-11-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 5fnuA00
2ZW9A 2VPJA 4IFJA 5FNSA 4ZY3A 3II7A 2XN4A 2DYHA 4XMBA 4N1BA 4L7BA 5FZJA 4ASCA 5FNRA 5FNUA 3WDZA 1U6DX 4CHBA 4YY8A 5CGJA 1ZGKA 2WOZA 4IQKA 2Z32A 4L7DA 3WN7A 1X2RA 3ZGDA 5FNQA 2ZWAA 1X2JA 4L7CA 3VNHA 4CH9A 5FNTA 4IN4A 3VNGA 3ZGCA 4IFLX 3ADEA 4ZGCA 5FZNA 4IFNX 2FLUX 2ZZKA 5F72C
chains in the Genus database with same CATH superfamily
4H53A 2HT7A 1SLLA 4O5SA 1F8DA 4HIZA 1W0OA 4DGRA 4YZ4A 3I1CA 1IVGA 4A0PA 1C5KA 1NCDN 2HTUA 2IVZA 1N1VA 3SRGA 2VVZA 1EUUA 4FOYA 1A4QA 3B69A 3JU4A 4WEFA 1CRUA 1S0IA 4MWJA 4XJ9A 3V64C 2HT8A 4FOWA 4AGIA 4XILA 2F0ZA 4FJ6A 2F26A 4D4UA 1KITA 4GNCA 2HTRA 2W5NA 4M3MA 4XMAA 4MWUA 4JF7A 1Z4XA 2FPCA 4YZ1A 3KYAA 2YA6A 3K39A 1W8NA 3DASA 1L7FA 1USRA 4GN8A 3ALXA 4WA3A 4L7DA 2IARA 1INFA 3WN7A 4XMIA 4FPJA 2P4OA 4C1YB 4CH9A 1INHA 4KS1A 2JKBA 2F13A 2H2UA 4K3YA 2QWBA 2A75A 3H71A 1USXA 1H6LA 1IUCA 3WWAA 1NMBN 3GVLA 4DG6A 1NCBN 4FPCA 3S8ZA 5D9BA 4WA5A 3DR2A 2HTWA 3H73A 1MS4A 4MJVA 4FOQA 3WW9A 4YZ3A 1WP5A 3O9KA 4K1IA 1W1XA 2B8HA 5HUKA 3K37A 1NN2A 3O9JA 4L7CA 5FNTA 3T1EA 1XOGA 1BJIA 3BEQA 4CPZA 2QWDA 2AGSA 3KGGA 3S2KA 1INWA 1W0PA 2YA7A 3W09A 4HZYA 4FP3A 3CKZA 1V0ZA 1E8VA 2ISMA 2FPBA 4GN9A 4XJUA 4XJAA 3A9HA 1N6DA 3ALWA 3A72A 4SLIA 1Z4VA 3H6JA 4XJ8A 2DG0A 3VNHA 4H52A 3SOVA 1N7DA 3VNGA 2AH2A 4FQ4A 4ZGCA 1IJQA 2F11A 3G4EA 4FOVA 4CPOA 1L7GA 3GVJA 4QN4A 5F72C 1E1AA 4FPKA 5FNSA 2ZB6A 4J9TA 4XYXA 2F29A 2XN4A 3TC9A 2H2NA 2G8SA 3TI5A 3UC1A 5HX0A 4IQKA 2SILA 1X2RA 5NN9A 4HW6A 4AH4A 4IMBA 4HZWA 1NPEA 1MZ5A 4FVKA 1NNCA 2BZDA 1NSDA 1MS0A 1E8UA 1F8BA 2FHRA 2W8BB 4YW2A 1QBIA 4B7MA 3U0SA 4M4NA 1B9TA 2FP8A 2F10A 3PJQA 4CSDA 3L6VA 1MS1A 4FPHA 4L7BA 3FW0A 3IAXA 2QWHA 4PWZA 5JYYA 1U6DX 2X9MA 1ZGKA 4CPMA 2IAWA 4GNBA 1DILA 4MX0A 4GEZA 4QNPA 5H47A 4HHQA 3GVKA 1CRZA 3CYEA 5HUGA 4HZZA 5EO7A 5D9CA 4IYGA 4FPLA 2VSKA 3SOBB 5HUNA 4O5TA 2GVWA 3CL2A 3BYCA 2IAPA 1A4GA 4CHBA 4D52C 2XZIA 5CGJA 2Z32A 5B2CA 1F8CA 4KS2A 5FNQA 2YA8A 4X6KA 4Q1UA 2IATA 2F24A 2QWCA 1OFZA 1MS9A 3A9GA 2QE8A 1DIMA 1IVEA 4YW1A 4NN9A 4MJUA 2GVUA 2VAQA 4XJRA 2ZB5A 2XCYA 7NN9A 1MS8A 3O4PA 2HTYA 3B7EA 3HLHA 4K1HA 3D12A 4CPYA 4K1KA 3E5ZA 2IAOA 1ZI0A 2VK5A 2IAQA 4YY8A 1C9UA 5EO8A 2YDTA 4MWWA 4MZAA 4FPGA 3K36A 4GZSA 4BBWA 3TI8A 1NMAN 4IFLX 4K1JA 3LI5A 1IVFA 3ADEA 3S8VA 4CPNA 1MS3A 1NSBA 2W20A 1N1TA 1NCCN 2AEQA 4GZQA 2W5OA 5M1ZA 4QN5A 2IAVA 3OPZA 4MWYA 1EUTA 4D52A 4GZTA 1EURA 4MWQA 1Z4ZA 5FNUA 5GX5A 2IASA 3SANA 2BF6A 3NO0A 2W38A 4XJZA 1INGA 1B9VA 3CL0A 3Q6PA 4XHBA 2F27A 4IFNX 4QN7A 2QWJA 4UOUA 4FPOB 2OJHA 3D11A 1SLIA 4B7RA 3S94A 5GX3A 4NC5A 1MWEA 4MC7A 5D9DA 3Q6TA 4XJQA 1RWLA 3SOQA 1Z4WA 1Z50A 3TI6A 3TI3A 1SNTA 1PJXA 2QWGA 2V91A 1E8TA 2FP9A 4QN6A 4X4AA 3HLIA 4M4VA 1CQ1A 4GZXA 4C1YA 1V3DA 1Q7FA 1QLGA 4CPLA 4IFJA 2VSMA 2XZJA 4MWVA 4GN7A 4N1BA 4B7JA 3TIBA 4ASCA 1IVDA 2QWFA 3AMRA 2VWDA 4XIOA 1NCAN 1X2JA 1RWIA 2QWAA 3FVZA 3ZGCA 4MWXA 2C4AA 1A14N 2DG1A 2HQSA 5FZNA 1V04A 1XOEA 2CMLA 3LI4A 4WA4A 2RKCA 2ZW9A 3NN9A 1V0EA 1VCJA 2HTVA 3II7A 4HZVA 1IVBA 3H72A 1W20A 2BERA 2IAUA 1N6EA 4I00A 4JMLA 2F25A 4NCSA 3TIAA 1IUBA 3Q6KA 1V3EA 3ZGDA 4FPYA 2F28A 4KS3A 4MWLA 4XE9A 2HU0A 2YA5A 2POOA 2GVXA 1CVMA 1MS5A 2VW2A 2QWKA 4FPFA 3LI3A 4XOGA 2FLUX 5GX2A 2HT5A 4ZY3A 2QWEA 3INBA 2DYHA 4XMBA 1S0JA 5FZJA 1SUUA 5FNRA 2GHSA 2YA4A 2DSOA 3SLIA 2F12A 1V3BA 2VK6A 2VW0A 4YZ2A 4KS4A 4GZOA 2SIMA 4KS5A 4YW5A 1NNAA 5EX7A 2HU4A 4MZEA 4XHXA 1WCQA 4B7NA 4MWRA 6NN9A 5F9TA 1N1SA 3SREA 2C4LA 4AGTA 4X47A 5GTQA 1W21A 2SLIA 3TICA 1EUSA 3SILA 2YDPA 2W8BA 4YZ5A 1IVCA 5GX1A 4GNAA 2VW1A 3P5BL 1MR5A 4XIKA 1S1DA 2WOZA 1V3CA 4D8SA 4X49A 4QN3A 1WCSA 1V0FA 4R40A 1MZ6A 4GDIA 4GB1A 2IAXA 3V65B 3A71A 3AMSA 1INVA 3HRPA 3TI4A 1N6FA 3SALA 2AEPA 2VPJA 4FP2A 1NMCA 1VCUA 4WEGA 5GX4A 1NSCA 2XZKA 1Z4YA 3WDZA 4HZXA 4M4UA 1NNBA 2BATA 4GJTA 4B7QA 1POOA 5HUMA 2HTQA 4YW3A 4IN4A 3G4HA 4G3NA 5B2DA 1F8EA 3NSSA 1INYA 4AHAA 2VK7A 3K3AA 4XJWA 2QWIA 4FPEA 1N1YA 4HHOA 4GZPA 3K38A 1W8OA 4GZWA 1K32A 4GDJA 4Q6KA 4YW4A 1L7HA 3V1SA 2ZWAA 1V2IA 1S18A 1SO7A 1INXA 2GVVA 4UF7A 5FWWA 4FZHA 4ZLRA 1B9SA 4D52B 2ZZKA
chains in the Genus database with same CATH topology
2ZW9A 2VPJA 4IFJA 5FNSA 4ZY3A 3II7A 2XN4A 2DYHA 4XMBA 4N1BA 4L7BA 5FZJA 4ASCA 5FNRA 5FNUA 3WDZA 1U6DX 4CHBA 4YY8A 5CGJA 1ZGKA 2WOZA 4IQKA 2Z32A 4L7DA 3WN7A 1X2RA 3ZGDA 5FNQA 2ZWAA 1X2JA 4L7CA 3VNHA 4CH9A 5FNTA 4IN4A 3VNGA 3ZGCA 4IFLX 3ADEA 4ZGCA 5FZNA 4IFNX 2FLUX 2ZZKA 5F72C
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ZW9 A;  2VPJ A;  4IFJ A;  5FNS A;  4ZY3 A;  3II7 A;  2XN4 A;  2DYH A;  4XMB A;  4N1B A;  4L7B A;  5FZJ A;  4ASC A;  5FNR A;  5FNU A;  3WDZ A;  1U6D X;  4CHB A;  4YY8 A;  5CGJ A;  1ZGK A;  2WOZ A;  4IQK A;  2Z32 A;  4L7D A;  3WN7 A;  1X2R A;  3ZGD A;  5FNQ A;  2ZWA A;  1X2J A;  4L7C A;  3VNH A;  4CH9 A;  5FNT A;  4IN4 A;  3VNG A;  3ZGC A;  4IFL X;  3ADE A;  4ZGC A;  5FZN A;  4IFN X;  2FLU X;  2ZZK A;  5F72 C; 
#chains in the Genus database with same CATH topology
 4H53 A;  2HT7 A;  1SLL A;  4O5S A;  1F8D A;  4HIZ A;  1W0O A;  4DGR A;  4YZ4 A;  3I1C A;  1IVG A;  4A0P A;  1C5K A;  1NCD N;  2HTU A;  2IVZ A;  1N1V A;  3SRG A;  2VVZ A;  1EUU A;  4FOY A;  1A4Q A;  3B69 A;  3JU4 A;  4WEF A;  1CRU A;  1S0I A;  4MWJ A;  4XJ9 A;  3V64 C;  2HT8 A;  4FOW A;  4AGI A;  4XIL A;  2F0Z A;  4FJ6 A;  2F26 A;  4D4U A;  1KIT A;  4GNC A;  2HTR A;  2W5N A;  4M3M A;  4XMA A;  4MWU A;  4JF7 A;  1Z4X A;  2FPC A;  4YZ1 A;  3KYA A;  2YA6 A;  3K39 A;  1W8N A;  3DAS A;  1L7F A;  1USR A;  4GN8 A;  3ALX A;  4WA3 A;  4L7D A;  2IAR A;  1INF A;  3WN7 A;  4XMI A;  4FPJ A;  2P4O A;  4C1Y B;  4CH9 A;  1INH A;  4KS1 A;  2JKB A;  2F13 A;  2H2U A;  4K3Y A;  2QWB A;  2A75 A;  3H71 A;  1USX A;  1H6L A;  1IUC A;  3WWA A;  1NMB N;  3GVL A;  4DG6 A;  1NCB N;  4FPC A;  3S8Z A;  5D9B A;  4WA5 A;  3DR2 A;  2HTW A;  3H73 A;  1MS4 A;  4MJV A;  4FOQ A;  3WW9 A;  4YZ3 A;  1WP5 A;  3O9K A;  4K1I A;  1W1X A;  2B8H A;  5HUK A;  3K37 A;  1NN2 A;  3O9J A;  4L7C A;  5FNT A;  3T1E A;  1XOG A;  1BJI A;  3BEQ A;  4CPZ A;  2QWD A;  2AGS A;  3KGG A;  3S2K A;  1INW A;  1W0P A;  2YA7 A;  3W09 A;  4HZY A;  4FP3 A;  3CKZ A;  1V0Z A;  1E8V A;  2ISM A;  2FPB A;  4GN9 A;  4XJU A;  4XJA A;  3A9H A;  1N6D A;  3ALW A;  3A72 A;  4SLI A;  1Z4V A;  3H6J A;  4XJ8 A;  2DG0 A;  3VNH A;  4H52 A;  3SOV A;  1N7D A;  3VNG A;  2AH2 A;  4FQ4 A;  4ZGC A;  1IJQ A;  2F11 A;  3G4E A;  4FOV A;  4CPO A;  1L7G A;  3GVJ A;  4QN4 A;  5F72 C;  1E1A A;  4FPK A;  5FNS A;  2ZB6 A;  4J9T A;  4XYX A;  2F29 A;  2XN4 A;  3TC9 A;  2H2N A;  2G8S A;  3TI5 A;  3UC1 A;  5HX0 A;  4IQK A;  2SIL A;  1X2R A;  5NN9 A;  4HW6 A;  4AH4 A;  4IMB A;  4HZW A;  1NPE A;  1MZ5 A;  4FVK A;  1NNC A;  2BZD A;  1NSD A;  1MS0 A;  1E8U A;  1F8B A;  2FHR A;  2W8B B;  4YW2 A;  1QBI A;  4B7M A;  3U0S A;  4M4N A;  1B9T A;  2FP8 A;  2F10 A;  3PJQ A;  4CSD A;  3L6V A;  1MS1 A;  4FPH A;  4L7B A;  3FW0 A;  3IAX A;  2QWH A;  4PWZ A;  5JYY A;  1U6D X;  2X9M A;  1ZGK A;  4CPM A;  2IAW A;  4GNB A;  1DIL A;  4MX0 A;  4GEZ A;  4QNP A;  5H47 A;  4HHQ A;  3GVK A;  1CRZ A;  3CYE A;  5HUG A;  4HZZ A;  5EO7 A;  5D9C A;  4IYG A;  4FPL A;  2VSK A;  3SOB B;  5HUN A;  4O5T A;  2GVW A;  3CL2 A;  3BYC A;  2IAP A;  1A4G A;  4CHB A;  4D52 C;  2XZI A;  5CGJ A;  2Z32 A;  5B2C A;  1F8C A;  4KS2 A;  5FNQ A;  2YA8 A;  4X6K A;  4Q1U A;  2IAT A;  2F24 A;  2QWC A;  1OFZ A;  1MS9 A;  3A9G A;  2QE8 A;  1DIM A;  1IVE A;  4YW1 A;  4NN9 A;  4MJU A;  2GVU A;  2VAQ A;  4XJR A;  2ZB5 A;  2XCY A;  7NN9 A;  1MS8 A;  3O4P A;  2HTY A;  3B7E A;  3HLH A;  4K1H A;  3D12 A;  4CPY A;  4K1K A;  3E5Z A;  2IAO A;  1ZI0 A;  2VK5 A;  2IAQ A;  4YY8 A;  1C9U A;  5EO8 A;  2YDT A;  4MWW A;  4MZA A;  4FPG A;  3K36 A;  4GZS A;  4BBW A;  3TI8 A;  1NMA N;  4IFL X;  4K1J A;  3LI5 A;  1IVF A;  3ADE A;  3S8V A;  4CPN A;  1MS3 A;  1NSB A;  2W20 A;  1N1T A;  1NCC N;  2AEQ A;  4GZQ A;  2W5O A;  5M1Z A;  4QN5 A;  2IAV A;  3OPZ A;  4MWY A;  1EUT A;  4D52 A;  4GZT A;  1EUR A;  4MWQ A;  1Z4Z A;  5FNU A;  5GX5 A;  2IAS A;  3SAN A;  2BF6 A;  3NO0 A;  2W38 A;  4XJZ A;  1ING A;  1B9V A;  3CL0 A;  3Q6P A;  4XHB A;  2F27 A;  4IFN X;  4QN7 A;  2QWJ A;  4UOU A;  4FPO B;  2OJH A;  3D11 A;  1SLI A;  4B7R A;  3S94 A;  5GX3 A;  4NC5 A;  1MWE A;  4MC7 A;  5D9D A;  3Q6T A;  4XJQ A;  1RWL A;  3SOQ A;  1Z4W A;  1Z50 A;  3TI6 A;  3TI3 A;  1SNT A;  1PJX A;  2QWG A;  2V91 A;  1E8T A;  2FP9 A;  4QN6 A;  4X4A A;  3HLI A;  4M4V A;  1CQ1 A;  4GZX A;  4C1Y A;  1V3D A;  1Q7F A;  1QLG A;  4CPL A;  4IFJ A;  2VSM A;  2XZJ A;  4MWV A;  4GN7 A;  4N1B A;  4B7J A;  3TIB A;  4ASC A;  1IVD A;  2QWF A;  3AMR A;  2VWD A;  4XIO A;  1NCA N;  1X2J A;  1RWI A;  2QWA A;  3FVZ A;  3ZGC A;  4MWX A;  2C4A A;  1A14 N;  2DG1 A;  2HQS A;  5FZN A;  1V04 A;  1XOE A;  2CML A;  3LI4 A;  4WA4 A;  2RKC A;  2ZW9 A;  3NN9 A;  1V0E A;  1VCJ A;  2HTV A;  3II7 A;  4HZV A;  1IVB A;  3H72 A;  1W20 A;  2BER A;  2IAU A;  1N6E A;  4I00 A;  4JML A;  2F25 A;  4NCS A;  3TIA A;  1IUB A;  3Q6K A;  1V3E A;  3ZGD A;  4FPY A;  2F28 A;  4KS3 A;  4MWL A;  4XE9 A;  2HU0 A;  2YA5 A;  2POO A;  2GVX A;  1CVM A;  1MS5 A;  2VW2 A;  2QWK A;  4FPF A;  3LI3 A;  4XOG A;  2FLU X;  5GX2 A;  2HT5 A;  4ZY3 A;  2QWE A;  3INB A;  2DYH A;  4XMB A;  1S0J A;  5FZJ A;  1SUU A;  5FNR A;  2GHS A;  2YA4 A;  2DSO A;  3SLI A;  2F12 A;  1V3B A;  2VK6 A;  2VW0 A;  4YZ2 A;  4KS4 A;  4GZO A;  2SIM A;  4KS5 A;  4YW5 A;  1NNA A;  5EX7 A;  2HU4 A;  4MZE A;  4XHX A;  1WCQ A;  4B7N A;  4MWR A;  6NN9 A;  5F9T A;  1N1S A;  3SRE A;  2C4L A;  4AGT A;  4X47 A;  5GTQ A;  1W21 A;  2SLI A;  3TIC A;  1EUS A;  3SIL A;  2YDP A;  2W8B A;  4YZ5 A;  1IVC A;  5GX1 A;  4GNA A;  2VW1 A;  3P5B L;  1MR5 A;  4XIK A;  1S1D A;  2WOZ A;  1V3C A;  4D8S A;  4X49 A;  4QN3 A;  1WCS A;  1V0F A;  4R40 A;  1MZ6 A;  4GDI A;  4GB1 A;  2IAX A;  3V65 B;  3A71 A;  3AMS A;  1INV A;  3HRP A;  3TI4 A;  1N6F A;  3SAL A;  2AEP A;  2VPJ A;  4FP2 A;  1NMC A;  1VCU A;  4WEG A;  5GX4 A;  1NSC A;  2XZK A;  1Z4Y A;  3WDZ A;  4HZX A;  4M4U A;  1NNB A;  2BAT A;  4GJT A;  4B7Q A;  1POO A;  5HUM A;  2HTQ A;  4YW3 A;  4IN4 A;  3G4H A;  4G3N A;  5B2D A;  1F8E A;  3NSS A;  1INY A;  4AHA A;  2VK7 A;  3K3A A;  4XJW A;  2QWI A;  4FPE A;  1N1Y A;  4HHO A;  4GZP A;  3K38 A;  1W8O A;  4GZW A;  1K32 A;  4GDJ A;  4Q6K A;  4YW4 A;  1L7H A;  3V1S A;  2ZWA A;  1V2I A;  1S18 A;  1SO7 A;  1INX A;  2GVV A;  4UF7 A;  5FWW A;  4FZH A;  4ZLR A;  1B9S A;  4D52 B;  2ZZK A; 
#chains in the Genus database with same CATH homology
 2ZW9 A;  2VPJ A;  4IFJ A;  5FNS A;  4ZY3 A;  3II7 A;  2XN4 A;  2DYH A;  4XMB A;  4N1B A;  4L7B A;  5FZJ A;  4ASC A;  5FNR A;  5FNU A;  3WDZ A;  1U6D X;  4CHB A;  4YY8 A;  5CGJ A;  1ZGK A;  2WOZ A;  4IQK A;  2Z32 A;  4L7D A;  3WN7 A;  1X2R A;  3ZGD A;  5FNQ A;  2ZWA A;  1X2J A;  4L7C A;  3VNH A;  4CH9 A;  5FNT A;  4IN4 A;  3VNG A;  3ZGC A;  4IFL X;  3ADE A;  4ZGC A;  5FZN A;  4IFN X;  2FLU X;  2ZZK A;  5F72 C; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...