The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
73
|
sequence length |
290
|
structure length |
290
|
Chain Sequence |
VGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Mono-Acidic Inhibitors of the Kelch-Like Ech-Associated Protein 1 : Nuclear Factor Erythroid 2-Related Factor 2 (Keap1:Nrf2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
pubmed doi rcsb |
| molecule keywords |
KELCH-LIKE ECH-ASSOCIATED PROTEIN 1
|
| molecule tags |
Inhibitor
|
| source organism |
Mus musculus
|
| total genus |
73
|
| structure length |
290
|
| sequence length |
290
|
| ec nomenclature | |
| pdb deposition date | 2016-03-15 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF01344 | Kelch_1 | Kelch motif |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Beta | 6 Propeller | Neuraminidase | Kelch-type beta propeller |
#chains in the Genus database with same CATH superfamily 5FNU A; 3VNG A; 2WOZ A; 4N1B A; 3ZGC A; 2ZW9 A; 3ZGD A; 5F72 C; 4IQK A; 4IN4 A; 4IFJ A; 5FNR A; 3II7 A; 4IFN X; 5FZJ A; 4YY8 A; 3VNH A; 4ASC A; 4ZGC A; 4CHB A; 1X2J A; 2XN4 A; 2VPJ A; 1X2R A; 5FNT A; 1U6D X; 4IFL X; 5FNS A; 4L7D A; 4L7C A; 4L7B A; 2FLU X; 2DYH A; 3ADE A; 4XMB A; 5FZN A; 2ZZK A; 4CH9 A; 5CGJ A; 4ZY3 A; 3WDZ A; 5FNQ A; 3WN7 A; 2ZWA A; 1ZGK A; 2Z32 A; #chains in the Genus database with same CATH topology 2AEQ A; 3JU4 A; 1V0Z A; 4XJQ A; 1B9V A; 4KS1 A; 3Q6P A; 3ZGD A; 2QWE A; 1S18 A; 3TIB A; 1NSC A; 1INH A; 2VK6 A; 3H71 A; 1XOG A; 4XIO A; 2XN4 A; 4GN8 A; 4HHQ A; 1IVC A; 4IYG A; 4CH9 A; 2F26 A; 4C1Y B; 5FNQ A; 4QN3 A; 4X6K A; 2F27 A; 1F8E A; 3TI6 A; 4FPG A; 4MC7 A; 3SAL A; 3W09 A; 3SOB B; 1W1X A; 3LI3 A; 3O4P A; 2F12 A; 4FPC A; 4B7J A; 2YA8 A; 4NCS A; 1Z4Y A; 2W8B A; 2YA4 A; 7NN9 A; 3TI3 A; 5JYY A; 2B8H A; 4KS5 A; 3FVZ A; 4YZ2 A; 2HT7 A; 3V64 C; 3TI4 A; 1MS4 A; 4FPY A; 2YDT A; 2RKC A; 1V3D A; 1A4G A; 4M4V A; 4GNA A; 4M4N A; 2ZWA A; 2QE8 A; 3WN7 A; 1NMC A; 1RWI A; 1RWL A; 3D11 A; 4MWJ A; 4X47 A; 4GEZ A; 2IAW A; 5D9D A; 2ISM A; 2IAO A; 1DIM A; 4QNP A; 2HU0 A; 4WEG A; 4MJU A; 3S8V A; 1WCS A; 2F13 A; 1V04 A; 1ZI0 A; 3O9J A; 2FP9 A; 2QWF A; 3SRE A; 1A14 N; 3SRG A; 2OJH A; 4FOQ A; 1V3E A; 3D12 A; 1C5K A; 1MS1 A; 4CPY A; 4IMB A; 4FPK A; 2XZI A; 4XJ9 A; 3LI5 A; 4FPE A; 3GVJ A; 1ZGK A; 3PJQ A; 2Z32 A; 1INF A; 3BEQ A; 5FNU A; 5H47 A; 3K39 A; 3S8Z A; 2C4A A; 3II7 A; 2DSO A; 4MJV A; 3S94 A; 4A0P A; 5HUN A; 5D9B A; 3DR2 A; 1WP5 A; 2FPB A; 3P5B L; 2YA5 A; 3DAS A; 4FPO B; 3A9G A; 4FOV A; 4FPL A; 1S0I A; 4DG6 A; 4XIK A; 3HLI A; 4I00 A; 2ZZK A; 4MWW A; 2QWI A; 1NCB N; 3K37 A; 1IUB A; 4GB1 A; 3Q6K A; 1NPE A; 4MWQ A; 5B2C A; 4D52 C; 1ING A; 1F8B A; 2HTR A; 3B69 A; 3G4H A; 4AGI A; 2BAT A; 3ZGC A; 4MWL A; 3G4E A; 2HU4 A; 2XZK A; 4FOY A; 1S0J A; 4FPJ A; 1F8D A; 3TIC A; 4GNC A; 3SOV A; 1IVE A; 1INX A; 2HTU A; 2AEP A; 4M4U A; 3CYE A; 2P4O A; 2QWA A; 3KGG A; 1C9U A; 1WCQ A; 2HTV A; 5HUM A; 4BBW A; 4HHO A; 3KYA A; 4HZY A; 4JML A; 4GZT A; 4XJW A; 1SLL A; 3CL2 A; 4HZX A; 3SLI A; 3Q6T A; 3TIA A; 4D52 A; 2W8B B; 4FJ6 A; 3CKZ A; 2F24 A; 3A71 A; 4XMA A; 5HUK A; 1Z4V A; 2QWD A; 2DYH A; 1N6F A; 5NN9 A; 4FP3 A; 3V65 B; 1A4Q A; 3INB A; 1N1S A; 3VNG A; 1KIT A; 2XCY A; 4YW1 A; 3LI4 A; 4GN7 A; 5FZJ A; 4IFN X; 1IJQ A; 1OFZ A; 1N1Y A; 3U0S A; 2SIM A; 2VAQ A; 2QWH A; 4R40 A; 4D4U A; 4YW2 A; 4FQ4 A; 1IVB A; 4AHA A; 3HRP A; 1F8C A; 5EX7 A; 5FZN A; 2QWC A; 5EO7 A; 4CPN A; 1CQ1 A; 1W0P A; 2BZD A; 4Q6K A; 1L7H A; 1Z50 A; 4AGT A; 4YZ5 A; 4HZW A; 2VWD A; 4YW4 A; 1V2I A; 1E8V A; 1SLI A; 4HZZ A; 5GTQ A; 4IN4 A; 2QWK A; 4GNB A; 3I1C A; 4YW5 A; 3IAX A; 2F10 A; 4CPL A; 3O9K A; 4MX0 A; 4YZ1 A; 4YZ3 A; 3NO0 A; 4QN6 A; 4XJR A; 4FVK A; 1N1V A; 2HTY A; 1EUU A; 1EUT A; 3B7E A; 3A72 A; 5HUG A; 3K3A A; 3NSS A; 2FPC A; 1POO A; 5GX2 A; 4MWX A; 1Z4Z A; 2XZJ A; 2VW2 A; 2GVX A; 5F9T A; 1Z4W A; 3UC1 A; 4H53 A; 1SNT A; 4X49 A; 4O5T A; 1QLG A; 2HTW A; 1MWE A; 1NMA N; 4MZA A; 4GDI A; 4CSD A; 1NSD A; 5FNT A; 4WEF A; 1NNC A; 2DG1 A; 2YDP A; 2IAQ A; 4MWV A; 2VW0 A; 1MS5 A; 3TI8 A; 3OPZ A; 1BJI A; 3AMS A; 4Q1U A; 1E1A A; 4UF7 A; 2ZW9 A; 4FPH A; 4HZV A; 4K3Y A; 4XJA A; 3VNH A; 4ZGC A; 4KS4 A; 4MWY A; 5M1Z A; 3S2K A; 1NCA N; 4AH4 A; 4QN5 A; 1U6D X; 4D52 B; 1N7D A; 2VW1 A; 1NNB A; 2AGS A; 4CPM A; 6NN9 A; 1DIL A; 2BER A; 2POO A; 1IVD A; 2W38 A; 1H6L A; 4K1H A; 2X9M A; 1MS0 A; 4FP2 A; 4G3N A; 4HW6 A; 2VK5 A; 5F72 C; 1MS3 A; 3K38 A; 1NN2 A; 1Q7F A; 1INV A; 1MR5 A; 3GVL A; 4ASC A; 4GZO A; 4CHB A; 1X2J A; 2W20 A; 2SIL A; 4L7D A; 5FWW A; 4XMB A; 3WWA A; 4WA4 A; 4XYX A; 4MWU A; 2YA6 A; 1S1D A; 4DGR A; 2F11 A; 4YW3 A; 4XJ8 A; 5EO8 A; 2FHR A; 3H72 A; 4FZH A; 2GHS A; 2VSK A; 4XJZ A; 4N1B A; 4XJU A; 4IQK A; 2IAU A; 1L7F A; 4K1I A; 1N6D A; 1IVG A; 4GZS A; 3TC9 A; 4H52 A; 2HT5 A; 5HX0 A; 1MZ5 A; 2H2U A; 2C4L A; 2VK7 A; 2BF6 A; 1N1T A; 1NMB N; 3CL0 A; 1X2R A; 2ZB5 A; 4XMI A; 1MS9 A; 4ZLR A; 3AMR A; 1K32 A; 1VCJ A; 4NN9 A; 4D8S A; 4PWZ A; 4M3M A; 4WA3 A; 1INY A; 3V1S A; 2F29 A; 2VVZ A; 2IAT A; 2W5O A; 4KS3 A; 4GZW A; 4O5S A; 4CPZ A; 1CRU A; 1EUR A; 3FW0 A; 2HT8 A; 4B7R A; 4FPF A; 3TI5 A; 4XIL A; 1V3B A; 4XHB A; 4K1K A; 3E5Z A; 4J9T A; 3SOQ A; 1V0E A; 1MZ6 A; 1IVF A; 1W21 A; 3ALX A; 4L7B A; 4C1Y A; 4B7M A; 4X4A A; 4ZY3 A; 3WDZ A; 4FOW A; 5GX4 A; 4QN7 A; 5GX1 A; 1XOE A; 5GX3 A; 1N6E A; 1USR A; 4K1J A; 4B7Q A; 4XHX A; 2IAR A; 2SLI A; 2G8S A; 2F0Z A; 1MS8 A; 3H6J A; 3ALW A; 2IAS A; 3A9H A; 4B7N A; 5FNR A; 1SUU A; 3L6V A; 1NNA A; 2IAX A; 3H73 A; 4YZ4 A; 4SLI A; 2GVW A; 1B9S A; 1IUC A; 1W8N A; 1NSB A; 4GZX A; 2IAV A; 2AH2 A; 4QN4 A; 5FNS A; 4L7C A; 1CRZ A; 1CVM A; 2QWB A; 1SO7 A; 4XE9 A; 2W5N A; 1B9T A; 2A75 A; 2GVU A; 2HTQ A; 4JF7 A; 1W0O A; 2GVV A; 3SAN A; 3WW9 A; 2F28 A; 2QWG A; 5GX5 A; 4KS2 A; 4MZE A; 1EUS A; 4IFJ A; 1L7G A; 2JKB A; 1INW A; 2DG0 A; 4HIZ A; 1V0F A; 4UOU A; 2IAP A; 4GDJ A; 2QWJ A; 2VPJ A; 3SIL A; 4GZP A; 2FLU X; 3NN9 A; 2ZB6 A; 5CGJ A; 1E8T A; 4CPO A; 1USX A; 2FP8 A; 4GJT A; 3BYC A; 4GZQ A; 4XOG A; 1PJX A; 3HLH A; 1VCU A; 4NC5 A; 2WOZ A; 2IVZ A; 4GN9 A; 3K36 A; 2F25 A; 1NCD N; 4YY8 A; 1Z4X A; 5D9C A; 1W20 A; 2HQS A; 3GVK A; 2CML A; 3T1E A; 1V3C A; 2YA7 A; 4IFL X; 1QBI A; 5B2D A; 3ADE A; 1E8U A; 1W8O A; 4MWR A; 2V91 A; 4WA5 A; 2H2N A; 1NCC N; 2VSM A; #chains in the Genus database with same CATH homology 5FNU A; 3VNG A; 2WOZ A; 4N1B A; 3ZGC A; 2ZW9 A; 3ZGD A; 5F72 C; 4IQK A; 4IN4 A; 4IFJ A; 5FNR A; 3II7 A; 4IFN X; 5FZJ A; 4YY8 A; 3VNH A; 4ASC A; 4ZGC A; 4CHB A; 1X2J A; 2XN4 A; 2VPJ A; 1X2R A; 5FNT A; 1U6D X; 4IFL X; 5FNS A; 4L7D A; 4L7C A; 4L7B A; 2FLU X; 2DYH A; 3ADE A; 4XMB A; 5FZN A; 2ZZK A; 4CH9 A; 5CGJ A; 4ZY3 A; 3WDZ A; 5FNQ A; 3WN7 A; 2ZWA A; 1ZGK A; 2Z32 A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
