1EGC | Genus

Total Genus 132

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	132
sequence length	387
structure length	387
Chain Sequence	LGFSFEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKERPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYGGTSQIQRLIVAREHIDKYKN

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Electron transfer
source organism	Homo sapiens
publication title	Crystal structures of the wild type and the Glu376Gly/Thr255Glu mutant of human medium-chain acyl-CoA dehydrogenase: influence of the location of the catalytic base on substrate specificity. pubmed doi rcsb
molecule keywords	MEDIUM CHAIN ACYL-COA DEHYDROGENASE
total genus	132
structure length	387
sequence length	387
chains with identical sequence	B, C, D
ec nomenclature	ec 1.3.8.7: Medium-chain acyl-CoA dehydrogenase.
pdb deposition date	1996-04-11

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00441	Acyl-CoA_dh_1	Acyl-CoA dehydrogenase, C-terminal domain
A	PF02770	Acyl-CoA_dh_M	Acyl-CoA dehydrogenase, middle domain
A	PF02771	Acyl-CoA_dh_N	Acyl-CoA dehydrogenase, N-terminal domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.540.10	Mainly Alpha	Orthogonal Bundle	Butyryl-Coa Dehydrogenase, subunit A; domain 1	Acyl-CoA dehydrogenase/oxidase, N-terminal domain	1egcA01
1.20.140.10	Mainly Alpha	Up-down Bundle	Butyryl-CoA Dehydrogenase, subunit A; domain 3	Butyryl-CoA Dehydrogenase, subunit A, domain 3	1egcA03
2.40.110.10	Mainly Beta	Beta Barrel	Butyryl-CoA Dehydrogenase, subunit A; domain 2	Butyryl-CoA Dehydrogenase, subunit A, domain 2	1egcA02

4L3YA 4NXLA 2WBIA 3BNHA 3EOMA 4IRNA 3RKHA 4ZXVA 3OWAA 3UBRA 2YYGA 2A1TA 4DOYA 3L1TA 4KCFA 3UU9A 1EGDA 2R0NA 3X0YA 1QDBA 4M9AA 2DDHA 4OO2A 3B96A 3D9GA 3FCJA 1IVHA 3MPIA 1IS2A 4XVXA 3BNGA 2D29A 2YYKA 2OT4A 4N5FA 3MDEA 2YYIA 3D6BA 4ZYJA 2C0UA 5K3JA 2VR0A 1R2JA 2JIFA 3X0XA 3PFDA 3SWOA 2CX9A 2R0MA 1FS8A 2YYJA 1UKWA 2ZO5A 1SIRA 1BUCA 1WS9A 4Q5BA 2RF7A 4U83A 1EGCA 3D9FA 2Z1QA 3GNCA 4O5MA 2RFQA 4JEKA 3S7WA 3SXQA 3TTBA 2C12A 1RX0A 4X28A 4L1FA 3D9EA 2IX6A 1FS9A 3LG1A 3GM6A 3M9VA 3MPJA 3D1IA 2E80A 4G5EA 2PG0A 3EONA 2E81A 2YYLA 2RDZA 2YYMA 1UDYA 2VIGA 3II9A 4X28C 4KTOA 3MDDA 4L3ZA 1EGEA 3NF4A 2EBAA 4RM7A 3R7KA 3HWCA 1JQIA 1T9GA 4L38A 3TORA 1U8VA 3SCEA 4HR3A 2J7AA 3D9DA 4L3XA 2JBSA 3F29A 4Q17A 4WJYA 5K3HA 3MXLA 1GU6A 3FO3A 2JBTA 5K3IA 2OR0A 5K3GA 4IV6A 1W07A 4P13A 3MMOA 3GQTA 2UXWA 3OIBA 2JBRA 2DVLA 2FONA 2IX5A 4Q4UA 3SF6A 3LGQA 1OAHA 3P4TA 1FS7A 2ZAFA 1SIQA 4Q1OA 3AFEA 3BNFA 3OWMA 4W9UA 2REHA 3BNJA 3MKHA 4Q0TA 4Q5CA 3AFFA
chains in the Genus database with same CATH superfamily

4L3YA 4NXLA 2WBIA 3BNHA 4MPEA 1GKZA 4AKHA 3EOMA 4IRNA 2BU8A 2E0AA 2ZDYA 4ZXVA 3OWAA 3RKHA 3UBRA 2EBFX 4FF4A 2YYGA 2A1TA 4DOYA 3L1TA 4KCFA 3UU9A 2XQRB 1EGDA 2R0NA 3X0YA 1QDBA 5M4KA 4M9AA 1GJVA 2DDHA 1GKXA 2XS1A 4OO2A 3B96A 2Q8IA 3D9GA 3FCJA 2EC5A 3C2PA 1IVHA 3MPIA 1K93A 1XFVA 3DJLA 1IS2A 4XVXA 5J71A 3Q23A 1Y8PA 2AO2A 3BNGA 4KSFA 2D29A 2YYKA 2OT4A 4N5FA 4E01A 4AKGA 3MDEA 2YYIA 1XG2B 3D6BA 4ZYJA 4FF2A 2C0UA 5K3JA 2VR0A 4HKRA 4MPCA 3TZ2A 1R2JA 2JIFA 5M4MA 1X91A 3X0XA 2GBBA 3CRKA 2CJ6A 4J1VA 3PFDA 2R05A 1SC5A 4P79A 3SWOA 2CX9A 2R0MA 1FS8A 2BU2A 2YYJA 4LQQB 1Y0VA 4JIOA 1XFWA 1UKWA 4H81A 4LQSB 2PNRA 2CJ5A 2XS8A 1SIRA 1BUCA 2ZO5A 3D2RA 1WS9A 4Q5BA 2RF7A 5GJVE 4E02A 4U83A 5M4NA 1EGCA 3D9FA 2Z1QA 3GNCA 4O5MA 2CJ4A 5J6AA 2RFQA 4JEKA 4HKSA 3S7WA 2YGWA 3SXQA 2F6LA 3TTBA 2C12A 2CJ7A 3VKHA 1RX0A 4X28A 4L1FA 1X8ZA 3D9EA 2IX6A 1FS9A 4H85A 3LG1A 3GM6A 4F0XA 3M9VA 3MPJA 1RJ4A 3D1IA 2EBHX 2E80A 3X29A 1RJ1A 2PO4A 4G5EA 3CE2A 2PG0A 2BU7A 3EONA 2E81A 2YYLA 2RDZA 2YYMA 5B5VA 1K90A 1UDYA 2VIGA 5BRMA 3II9A 4X28C 4MPNA 4KTOA 3MDDA 4L3ZA 2Q8FA 2FP2A 1EGEA 2OEXA 1JM6A 4MP2A 3NF4A 2EBAA 4V25A 2Q8GA 1XFUA 3TZ0A 3C3LA 4RM7A 3R7KA 4G97A 5B6BA 2FP1A 3HWCA 4FF3A 1XFYA 4V26A 1JQIA 1T9GA 4L38A 2Q8HA 1S26A 3TORA 1U8VA 3SCEA 4HR3A 2J7AA 3D9DA 4L3XA 2JBSA 4JIZA 4FZ4A 1PK0A 3F29A 3N0RA 4AKIA 2CJ8A 1R3BA 4Q17A 4WJYA 5K3HA 3MXLA 4MP7A 3TZ4A 3VADA 1GU6A 1SK6A 2LFWA 3FO3A 2VF1A 2JBTA 5K3IA 2OEVA 2R02A 3Q24A 2OR0A 5K3GA 2ZDXA 5EZ3A 3CRLA 2OJQA 4IV6A 1W07A 3TZ5A 4FF1A 1K8TA 2BU5A 4P13A 2QR4A 3MMOA 5GJWE 5BRKA 5M4PA 3C46A 4AI6A 3GQTA 2UXWA 3OIBA 2BTZA 2JBRA 4H7QA 2HJNA 2DVLA 2FONA 2IX5A 2R03A 4Q4UA 3SF6A 1LVCA 4KS9A 3Q22A 3U33A 5B5WA 3LGQA 1OAHA 4E00A 3P4TA 1FS7A 4QICA 2ZAFA 1SIQA 1X90A 3AFEA 2AZEA 4Q1OA 3BNFA 3OWMA 4W9UA 2REHA 1RP3A 1XFXA 3KMLA 4KSAA 3VKGA 1XFZA 3BNJA 4DZYA 2BU6A 3MKHA 2ZKJA 1Y8OA 4Q0TA 3Q0AA 1PI1A 4Q5CA 3AFFA 1Y8NA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 4L3Y A;  4NXL A;  2WBI A;  3BNH A;  3EOM A;  4IRN A;  3RKH A;  4ZXV A;  3OWA A;  3UBR A;  2YYG A;  2A1T A;  4DOY A;  3L1T A;  4KCF A;  3UU9 A;  1EGD A;  2R0N A;  3X0Y A;  1QDB A;  4M9A A;  2DDH A;  4OO2 A;  3B96 A;  3D9G A;  3FCJ A;  1IVH A;  3MPI A;  1IS2 A;  4XVX A;  3BNG A;  2D29 A;  2YYK A;  2OT4 A;  4N5F A;  3MDE A;  2YYI A;  3D6B A;  4ZYJ A;  2C0U A;  5K3J A;  2VR0 A;  1R2J A;  2JIF A;  3X0X A;  3PFD A;  3SWO A;  2CX9 A;  2R0M A;  1FS8 A;  2YYJ A;  1UKW A;  2ZO5 A;  1SIR A;  1BUC A;  1WS9 A;  4Q5B A;  2RF7 A;  4U83 A;  1EGC A;  3D9F A;  2Z1Q A;  3GNC A;  4O5M A;  2RFQ A;  4JEK A;  3S7W A;  3SXQ A;  3TTB A;  2C12 A;  1RX0 A;  4X28 A;  4L1F A;  3D9E A;  2IX6 A;  1FS9 A;  3LG1 A;  3GM6 A;  3M9V A;  3MPJ A;  3D1I A;  2E80 A;  4G5E A;  2PG0 A;  3EON A;  2E81 A;  2YYL A;  2RDZ A;  2YYM A;  1UDY A;  2VIG A;  3II9 A;  4X28 C;  4KTO A;  3MDD A;  4L3Z A;  1EGE A;  3NF4 A;  2EBA A;  4RM7 A;  3R7K A;  3HWC A;  1JQI A;  1T9G A;  4L38 A;  3TOR A;  1U8V A;  3SCE A;  4HR3 A;  2J7A A;  3D9D A;  4L3X A;  2JBS A;  3F29 A;  4Q17 A;  4WJY A;  5K3H A;  3MXL A;  1GU6 A;  3FO3 A;  2JBT A;  5K3I A;  2OR0 A;  5K3G A;  4IV6 A;  1W07 A;  4P13 A;  3MMO A;  3GQT A;  2UXW A;  3OIB A;  2JBR A;  2DVL A;  2FON A;  2IX5 A;  4Q4U A;  3SF6 A;  3LGQ A;  1OAH A;  3P4T A;  1FS7 A;  2ZAF A;  1SIQ A;  4Q1O A;  3AFE A;  3BNF A;  3OWM A;  4W9U A;  2REH A;  3BNJ A;  3MKH A;  4Q0T A;  4Q5C A;  3AFF A; 
#chains in the Genus database with same CATH topology
 4L3Y A;  4NXL A;  2WBI A;  3BNH A;  4MPE A;  1GKZ A;  4AKH A;  3EOM A;  4IRN A;  2BU8 A;  2E0A A;  2ZDY A;  4ZXV A;  3OWA A;  3RKH A;  3UBR A;  2EBF X;  4FF4 A;  2YYG A;  2A1T A;  4DOY A;  3L1T A;  4KCF A;  3UU9 A;  2XQR B;  1EGD A;  2R0N A;  3X0Y A;  1QDB A;  5M4K A;  4M9A A;  1GJV A;  2DDH A;  1GKX A;  2XS1 A;  4OO2 A;  3B96 A;  2Q8I A;  3D9G A;  3FCJ A;  2EC5 A;  3C2P A;  1IVH A;  3MPI A;  1K93 A;  1XFV A;  3DJL A;  1IS2 A;  4XVX A;  5J71 A;  3Q23 A;  1Y8P A;  2AO2 A;  3BNG A;  4KSF A;  2D29 A;  2YYK A;  2OT4 A;  4N5F A;  4E01 A;  4AKG A;  3MDE A;  2YYI A;  1XG2 B;  3D6B A;  4ZYJ A;  4FF2 A;  2C0U A;  5K3J A;  2VR0 A;  4HKR A;  4MPC A;  3TZ2 A;  1R2J A;  2JIF A;  5M4M A;  1X91 A;  3X0X A;  2GBB A;  3CRK A;  2CJ6 A;  4J1V A;  3PFD A;  2R05 A;  1SC5 A;  4P79 A;  3SWO A;  2CX9 A;  2R0M A;  1FS8 A;  2BU2 A;  2YYJ A;  4LQQ B;  1Y0V A;  4JIO A;  1XFW A;  1UKW A;  4H81 A;  4LQS B;  2PNR A;  2CJ5 A;  2XS8 A;  1SIR A;  1BUC A;  2ZO5 A;  3D2R A;  1WS9 A;  4Q5B A;  2RF7 A;  5GJV E;  4E02 A;  4U83 A;  5M4N A;  1EGC A;  3D9F A;  2Z1Q A;  3GNC A;  4O5M A;  2CJ4 A;  5J6A A;  2RFQ A;  4JEK A;  4HKS A;  3S7W A;  2YGW A;  3SXQ A;  2F6L A;  3TTB A;  2C12 A;  2CJ7 A;  3VKH A;  1RX0 A;  4X28 A;  4L1F A;  1X8Z A;  3D9E A;  2IX6 A;  1FS9 A;  4H85 A;  3LG1 A;  3GM6 A;  4F0X A;  3M9V A;  3MPJ A;  1RJ4 A;  3D1I A;  2EBH X;  2E80 A;  3X29 A;  1RJ1 A;  2PO4 A;  4G5E A;  3CE2 A;  2PG0 A;  2BU7 A;  3EON A;  2E81 A;  2YYL A;  2RDZ A;  2YYM A;  5B5V A;  1K90 A;  1UDY A;  2VIG A;  5BRM A;  3II9 A;  4X28 C;  4MPN A;  4KTO A;  3MDD A;  4L3Z A;  2Q8F A;  2FP2 A;  1EGE A;  2OEX A;  1JM6 A;  4MP2 A;  3NF4 A;  2EBA A;  4V25 A;  2Q8G A;  1XFU A;  3TZ0 A;  3C3L A;  4RM7 A;  3R7K A;  4G97 A;  5B6B A;  2FP1 A;  3HWC A;  4FF3 A;  1XFY A;  4V26 A;  1JQI A;  1T9G A;  4L38 A;  2Q8H A;  1S26 A;  3TOR A;  1U8V A;  3SCE A;  4HR3 A;  2J7A A;  3D9D A;  4L3X A;  2JBS A;  4JIZ A;  4FZ4 A;  1PK0 A;  3F29 A;  3N0R A;  4AKI A;  2CJ8 A;  1R3B A;  4Q17 A;  4WJY A;  5K3H A;  3MXL A;  4MP7 A;  3TZ4 A;  3VAD A;  1GU6 A;  1SK6 A;  2LFW A;  3FO3 A;  2VF1 A;  2JBT A;  5K3I A;  2OEV A;  2R02 A;  3Q24 A;  2OR0 A;  5K3G A;  2ZDX A;  5EZ3 A;  3CRL A;  2OJQ A;  4IV6 A;  1W07 A;  3TZ5 A;  4FF1 A;  1K8T A;  2BU5 A;  4P13 A;  2QR4 A;  3MMO A;  5GJW E;  5BRK A;  5M4P A;  3C46 A;  4AI6 A;  3GQT A;  2UXW A;  3OIB A;  2BTZ A;  2JBR A;  4H7Q A;  2HJN A;  2DVL A;  2FON A;  2IX5 A;  2R03 A;  4Q4U A;  3SF6 A;  1LVC A;  4KS9 A;  3Q22 A;  3U33 A;  5B5W A;  3LGQ A;  1OAH A;  4E00 A;  3P4T A;  1FS7 A;  4QIC A;  2ZAF A;  1SIQ A;  1X90 A;  3AFE A;  2AZE A;  4Q1O A;  3BNF A;  3OWM A;  4W9U A;  2REH A;  1RP3 A;  1XFX A;  3KML A;  4KSA A;  3VKG A;  1XFZ A;  3BNJ A;  4DZY A;  2BU6 A;  3MKH A;  2ZKJ A;  1Y8O A;  4Q0T A;  3Q0A A;  1PI1 A;  4Q5C A;  3AFF A;  1Y8N A; 
#chains in the Genus database with same CATH homology
 4L3Y A;  4NXL A;  2WBI A;  3BNH A;  3EOM A;  4IRN A;  3RKH A;  4ZXV A;  3OWA A;  3UBR A;  2YYG A;  2A1T A;  4DOY A;  3L1T A;  4KCF A;  3UU9 A;  1EGD A;  2R0N A;  3X0Y A;  1QDB A;  4M9A A;  2DDH A;  4OO2 A;  3B96 A;  3D9G A;  3FCJ A;  1IVH A;  3MPI A;  1IS2 A;  4XVX A;  3BNG A;  2D29 A;  2YYK A;  2OT4 A;  4N5F A;  3MDE A;  2YYI A;  3D6B A;  4ZYJ A;  2C0U A;  5K3J A;  2VR0 A;  1R2J A;  2JIF A;  3X0X A;  3PFD A;  3SWO A;  2CX9 A;  2R0M A;  1FS8 A;  2YYJ A;  1UKW A;  2ZO5 A;  1SIR A;  1BUC A;  1WS9 A;  4Q5B A;  2RF7 A;  4U83 A;  1EGC A;  3D9F A;  2Z1Q A;  3GNC A;  4O5M A;  2RFQ A;  4JEK A;  3S7W A;  3SXQ A;  3TTB A;  2C12 A;  1RX0 A;  4X28 A;  4L1F A;  3D9E A;  2IX6 A;  1FS9 A;  3LG1 A;  3GM6 A;  3M9V A;  3MPJ A;  3D1I A;  2E80 A;  4G5E A;  2PG0 A;  3EON A;  2E81 A;  2YYL A;  2RDZ A;  2YYM A;  1UDY A;  2VIG A;  3II9 A;  4X28 C;  4KTO A;  3MDD A;  4L3Z A;  1EGE A;  3NF4 A;  2EBA A;  4RM7 A;  3R7K A;  3HWC A;  1JQI A;  1T9G A;  4L38 A;  3TOR A;  1U8V A;  3SCE A;  4HR3 A;  2J7A A;  3D9D A;  4L3X A;  2JBS A;  3F29 A;  4Q17 A;  4WJY A;  5K3H A;  3MXL A;  1GU6 A;  3FO3 A;  2JBT A;  5K3I A;  2OR0 A;  5K3G A;  4IV6 A;  1W07 A;  4P13 A;  3MMO A;  3GQT A;  2UXW A;  3OIB A;  2JBR A;  2DVL A;  2FON A;  2IX5 A;  4Q4U A;  3SF6 A;  3LGQ A;  1OAH A;  3P4T A;  1FS7 A;  2ZAF A;  1SIQ A;  4Q1O A;  3AFE A;  3BNF A;  3OWM A;  4W9U A;  2REH A;  3BNJ A;  3MKH A;  4Q0T A;  4Q5C A;  3AFF A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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1EGCA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations