1EGDA

Structure of t255e, e376g mutant of human medium chain acyl-coa dehydrogenase
Total Genus 148
50100150200250300350020406080100120140
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
148
sequence length
387
structure length
387
Chain Sequence
LGFSFEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKERPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYGGTSQIQRLIVAREHIDKYKN
5010015020025030035035030025020015010050
050100Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
AH1 (18-45)AH3 (77-90)S6 (206-211)TI6 (357-360)TI4 (200-203)S3 (157-168)EMPTYO1 (48-50)AH2 (50-59)AH5 (114-126)AH4 (92-110)TIV1 (61-64)3H1 (68-70)AH6 (244-279)AH9 (361-369)3H3 (190-192)TII1 (167-170)TII'1 (154-157)O2 (127-129)S1 (131-134)TI2 (137-140)TII2 (169-172)TIV2 (140-143)S2 (150-154)TI5 (217-220)TIV5 (215-218)TI3 (185-188)TVIII1 (173-176)TIV4 (170-173)S7 (222-233)S4 (175-181)3H4 (234-236)S5 (194-200)TIV7 (237-240)AH8 (325-356)S8 (282-283)TIV8 (282-285)3H5 (288-290)S9 (286-287)AH10 (379-393)AH7 (292-320)3H6 (370-373)TII5 (374-377)TIV9 (375-378)3H2 (144-146)TI1 (63-66)TII4 (240-243)Updating...
connected with : NaN
molecule tags Electron transfer
source organism Homo sapiens
publication title Crystal structures of the wild type and the Glu376Gly/Thr255Glu mutant of human medium-chain acyl-CoA dehydrogenase: influence of the location of the catalytic base on substrate specificity.
pubmed doi rcsb
molecule keywords MEDIUM CHAIN ACYL-COA DEHYDROGENASE
total genus 148
structure length 387
sequence length 387
chains with identical sequence B, C, D
ec nomenclature ec 1.3.8.7: Medium-chain acyl-CoA dehydrogenase.
pdb deposition date 1996-04-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00441 Acyl-CoA_dh_1 Acyl-CoA dehydrogenase, C-terminal domain
A PF02770 Acyl-CoA_dh_M Acyl-CoA dehydrogenase, middle domain
A PF02771 Acyl-CoA_dh_N Acyl-CoA dehydrogenase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.540.10 Mainly Alpha Orthogonal Bundle Butyryl-Coa Dehydrogenase, subunit A; domain 1 Acyl-CoA dehydrogenase/oxidase, N-terminal domain 1egdA01
1.20.140.10 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A, domain 3 1egdA03
2.40.110.10 Mainly Beta Beta Barrel Butyryl-CoA Dehydrogenase, subunit A; domain 2 Butyryl-CoA Dehydrogenase, subunit A, domain 2 1egdA02
2RF7A 2YYIA 5K3IA 2R0MA 3AFFA 3D9FA 4XVXA 3MPIA 4M9AA 3LGQA 2WBIA 3MPJA 4ZYJA 2YYJA 3EOMA 1W07A 4NXLA 2IX6A 2DVLA 2PG0A 4X28C 3B96A 4P13A 3MDEA 1EGDA 4HR3A 3MDDA 2YYMA 3SCEA 2E81A 3MKHA 4N5FA 3MMOA 2CX9A 4W9UA 1UDYA 3D6BA 4ZXVA 3GM6A 2VIGA 4JEKA 2YYKA 3D9EA 1SIQA 5K3JA 3D9DA 3GNCA 1JQIA 3FO3A 2JBSA 2C12A 4L3ZA 3MXLA 1FS8A 2RFQA 2ZO5A 3SWOA 3OWMA 2R0NA 2JIFA 2C0UA 3BNFA 3SF6A 2JBRA 2IX5A 1FS9A 4IV6A 1R2JA 2D29A 3D1IA 3UBRA 3GQTA 4L38A 2ZAFA 2Z1QA 3X0XA 4DOYA 4Q0TA 4Q1OA 2JBTA 5K3HA 4WJYA 1RX0A 2EBAA 2YYGA 2REHA 4OO2A 2RDZA 3F29A 3R7KA 4KTOA 2J7AA 1U8VA 4G5EA 4O5MA 3LG1A 2E80A 1EGCA 4IRNA 4U83A 1EGEA 4L3YA 4RM7A 3UU9A 3SXQA 1SIRA 3X0YA 4Q4UA 3S7WA 4L3XA 1QDBA 1IVHA 4Q17A 1OAHA 1FS7A 3L1TA 2FONA 2YYLA 2VR0A 1T9GA 3EONA 1UKWA 1IS2A 2DDHA 5K3GA 1BUCA 3RKHA 1GU6A 4KCFA 3NF4A 3AFEA 2A1TA 3D9GA 3OIBA 3PFDA 3HWCA 3P4TA 2UXWA 3M9VA 3II9A 4Q5BA 3TTBA 1WS9A 2OR0A 3OWAA 3BNHA 2OT4A 3TORA 3BNJA 3BNGA 4L1FA 3FCJA 4Q5CA 4X28A
chains in the Genus database with same CATH superfamily
2RF7A 2YYIA 4E00A 2Q8GA 1XG2B 4MP7A 1K93A 2BU7A 5BRMA 5K3IA 2R0MA 2R05A 3AFFA 3D9FA 4QICA 4XVXA 1XFWA 3MPIA 2HJNA 4M9AA 4J1VA 3LGQA 2WBIA 1Y8PA 3MPJA 4ZYJA 4MPEA 2YYJA 3EOMA 2CJ8A 1RJ1A 3Q0AA 1W07A 4NXLA 2IX6A 2OJQA 3KMLA 2DVLA 2PG0A 4X28C 4F0XA 3B96A 1RP3A 4P13A 3MDEA 2VF1A 1EGDA 2CJ5A 4HR3A 2Q8HA 2EBFX 3MDDA 2BU8A 2YYMA 3SCEA 4KS9A 2E81A 4E02A 3MKHA 2CJ4A 4N5FA 1JM6A 3D2RA 4AKHA 1GJVA 3MMOA 2CX9A 4W9UA 4AKIA 1UDYA 3D6BA 4ZXVA 3GM6A 5EZ3A 2VIGA 2F6LA 4JEKA 2YYKA 3D9EA 1XFYA 1SIQA 1GKZA 2AO2A 1PI1A 5K3JA 5B5WA 3D9DA 1XFXA 1XFVA 1Y0VA 4AI6A 3GNCA 3N0RA 1JQIA 2GBBA 3FO3A 4H81A 2JBSA 3CRLA 2C12A 4L3ZA 3MXLA 1FS8A 4H7QA 1Y8NA 2RFQA 5M4PA 2ZO5A 2BU6A 4FZ4A 3SWOA 4KSFA 2ZDXA 3OWMA 2R0NA 1XFZA 5GJVE 2JIFA 2BU2A 4JIZA 4DZYA 2C0UA 1X8ZA 2LFWA 3C3LA 1K90A 2FP1A 3BNFA 3SF6A 2Q8FA 2JBRA 2IX5A 1FS9A 4IV6A 2R02A 1R2JA 2D29A 1SK6A 3D1IA 4MPNA 3GQTA 4L38A 3UBRA 4FF2A 4HKSA 2PO4A 3TZ0A 1LVCA 2ZAFA 3C46A 1X91A 2Z1QA 3X0XA 1S26A 4DOYA 4Q0TA 4Q1OA 1PK0A 5B6BA 2JBTA 4KSAA 3VKGA 5K3HA 2EC5A 4WJYA 5M4NA 2BTZA 1RX0A 2XS8A 2EBAA 2YYGA 2REHA 3TZ4A 4OO2A 4FF3A 2CJ6A 5B5VA 2RDZA 2OEXA 3F29A 3R7KA 4LQQB 4KTOA 2J7AA 3VADA 2ZKJA 1U8VA 4MP2A 3CE2A 2Q8IA 4G5EA 4O5MA 3LG1A 1XFUA 2E80A 1EGCA 4IRNA 3U33A 4U83A 2FP2A 3CRKA 3VKHA 3X29A 1EGEA 4L3YA 4RM7A 3UU9A 1GKXA 4E01A 2CJ7A 5BRKA 3TZ5A 3DJLA 3SXQA 1SIRA 3X0YA 2E0AA 4JIOA 4L3XA 1QDBA 4Q4UA 3S7WA 1IVHA 4Q17A 1OAHA 1R3BA 1FS7A 3L1TA 2FONA 3Q24A 2YYLA 2VR0A 4MPCA 1T9GA 2BU5A 5J6AA 5M4KA 3EONA 4G97A 4FF1A 1UKWA 2QR4A 1IS2A 2DDHA 3Q22A 5K3GA 1BUCA 3RKHA 1GU6A 2ZDYA 4KCFA 1SC5A 3TZ2A 5M4MA 1K8TA 2PNRA 4AKGA 3NF4A 3AFEA 2A1TA 3D9GA 3OIBA 3PFDA 2OEVA 1Y8OA 3HWCA 4FF4A 4H85A 2EBHX 4P79A 3Q23A 4V25A 1X90A 2YGWA 3P4TA 5J71A 2UXWA 3M9VA 3C2PA 3II9A 4Q5BA 3TTBA 2XS1A 1WS9A 2OR0A 3OWAA 2R03A 3BNHA 5GJWE 2OT4A 3BNJA 3TORA 2AZEA 4V26A 3BNGA 2XQRB 4HKRA 4LQSB 4L1FA 3FCJA 4Q5CA 4X28A 1RJ4A
chains in the Genus database with same CATH topology
2RF7A 2YYIA 5K3IA 2R0MA 3AFFA 3D9FA 4XVXA 3MPIA 4M9AA 3LGQA 2WBIA 3MPJA 4ZYJA 2YYJA 3EOMA 1W07A 4NXLA 2IX6A 2DVLA 2PG0A 4X28C 3B96A 4P13A 3MDEA 1EGDA 4HR3A 3MDDA 2YYMA 3SCEA 2E81A 3MKHA 4N5FA 3MMOA 2CX9A 4W9UA 1UDYA 3D6BA 4ZXVA 3GM6A 2VIGA 4JEKA 2YYKA 3D9EA 1SIQA 5K3JA 3D9DA 3GNCA 1JQIA 3FO3A 2JBSA 2C12A 4L3ZA 3MXLA 1FS8A 2RFQA 2ZO5A 3SWOA 3OWMA 2R0NA 2JIFA 2C0UA 3BNFA 3SF6A 2JBRA 2IX5A 1FS9A 4IV6A 1R2JA 2D29A 3D1IA 3UBRA 3GQTA 4L38A 2ZAFA 2Z1QA 3X0XA 4DOYA 4Q0TA 4Q1OA 2JBTA 5K3HA 4WJYA 1RX0A 2EBAA 2YYGA 2REHA 4OO2A 2RDZA 3F29A 3R7KA 4KTOA 2J7AA 1U8VA 4G5EA 4O5MA 3LG1A 2E80A 1EGCA 4IRNA 4U83A 1EGEA 4L3YA 4RM7A 3UU9A 3SXQA 1SIRA 3X0YA 4Q4UA 3S7WA 4L3XA 1QDBA 1IVHA 4Q17A 1OAHA 1FS7A 3L1TA 2FONA 2YYLA 2VR0A 1T9GA 3EONA 1UKWA 1IS2A 2DDHA 5K3GA 1BUCA 3RKHA 1GU6A 4KCFA 3NF4A 3AFEA 2A1TA 3D9GA 3OIBA 3PFDA 3HWCA 3P4TA 2UXWA 3M9VA 3II9A 4Q5BA 3TTBA 1WS9A 2OR0A 3OWAA 3BNHA 2OT4A 3TORA 3BNJA 3BNGA 4L1FA 3FCJA 4Q5CA 4X28A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2RF7 A;  2YYI A;  5K3I A;  2R0M A;  3AFF A;  3D9F A;  4XVX A;  3MPI A;  4M9A A;  3LGQ A;  2WBI A;  3MPJ A;  4ZYJ A;  2YYJ A;  3EOM A;  1W07 A;  4NXL A;  2IX6 A;  2DVL A;  2PG0 A;  4X28 C;  3B96 A;  4P13 A;  3MDE A;  1EGD A;  4HR3 A;  3MDD A;  2YYM A;  3SCE A;  2E81 A;  3MKH A;  4N5F A;  3MMO A;  2CX9 A;  4W9U A;  1UDY A;  3D6B A;  4ZXV A;  3GM6 A;  2VIG A;  4JEK A;  2YYK A;  3D9E A;  1SIQ A;  5K3J A;  3D9D A;  3GNC A;  1JQI A;  3FO3 A;  2JBS A;  2C12 A;  4L3Z A;  3MXL A;  1FS8 A;  2RFQ A;  2ZO5 A;  3SWO A;  3OWM A;  2R0N A;  2JIF A;  2C0U A;  3BNF A;  3SF6 A;  2JBR A;  2IX5 A;  1FS9 A;  4IV6 A;  1R2J A;  2D29 A;  3D1I A;  3UBR A;  3GQT A;  4L38 A;  2ZAF A;  2Z1Q A;  3X0X A;  4DOY A;  4Q0T A;  4Q1O A;  2JBT A;  5K3H A;  4WJY A;  1RX0 A;  2EBA A;  2YYG A;  2REH A;  4OO2 A;  2RDZ A;  3F29 A;  3R7K A;  4KTO A;  2J7A A;  1U8V A;  4G5E A;  4O5M A;  3LG1 A;  2E80 A;  1EGC A;  4IRN A;  4U83 A;  1EGE A;  4L3Y A;  4RM7 A;  3UU9 A;  3SXQ A;  1SIR A;  3X0Y A;  4Q4U A;  3S7W A;  4L3X A;  1QDB A;  1IVH A;  4Q17 A;  1OAH A;  1FS7 A;  3L1T A;  2FON A;  2YYL A;  2VR0 A;  1T9G A;  3EON A;  1UKW A;  1IS2 A;  2DDH A;  5K3G A;  1BUC A;  3RKH A;  1GU6 A;  4KCF A;  3NF4 A;  3AFE A;  2A1T A;  3D9G A;  3OIB A;  3PFD A;  3HWC A;  3P4T A;  2UXW A;  3M9V A;  3II9 A;  4Q5B A;  3TTB A;  1WS9 A;  2OR0 A;  3OWA A;  3BNH A;  2OT4 A;  3TOR A;  3BNJ A;  3BNG A;  4L1F A;  3FCJ A;  4Q5C A;  4X28 A; 
#chains in the Genus database with same CATH topology
 2RF7 A;  2YYI A;  4E00 A;  2Q8G A;  1XG2 B;  4MP7 A;  1K93 A;  2BU7 A;  5BRM A;  5K3I A;  2R0M A;  2R05 A;  3AFF A;  3D9F A;  4QIC A;  4XVX A;  1XFW A;  3MPI A;  2HJN A;  4M9A A;  4J1V A;  3LGQ A;  2WBI A;  1Y8P A;  3MPJ A;  4ZYJ A;  4MPE A;  2YYJ A;  3EOM A;  2CJ8 A;  1RJ1 A;  3Q0A A;  1W07 A;  4NXL A;  2IX6 A;  2OJQ A;  3KML A;  2DVL A;  2PG0 A;  4X28 C;  4F0X A;  3B96 A;  1RP3 A;  4P13 A;  3MDE A;  2VF1 A;  1EGD A;  2CJ5 A;  4HR3 A;  2Q8H A;  2EBF X;  3MDD A;  2BU8 A;  2YYM A;  3SCE A;  4KS9 A;  2E81 A;  4E02 A;  3MKH A;  2CJ4 A;  4N5F A;  1JM6 A;  3D2R A;  4AKH A;  1GJV A;  3MMO A;  2CX9 A;  4W9U A;  4AKI A;  1UDY A;  3D6B A;  4ZXV A;  3GM6 A;  5EZ3 A;  2VIG A;  2F6L A;  4JEK A;  2YYK A;  3D9E A;  1XFY A;  1SIQ A;  1GKZ A;  2AO2 A;  1PI1 A;  5K3J A;  5B5W A;  3D9D A;  1XFX A;  1XFV A;  1Y0V A;  4AI6 A;  3GNC A;  3N0R A;  1JQI A;  2GBB A;  3FO3 A;  4H81 A;  2JBS A;  3CRL A;  2C12 A;  4L3Z A;  3MXL A;  1FS8 A;  4H7Q A;  1Y8N A;  2RFQ A;  5M4P A;  2ZO5 A;  2BU6 A;  4FZ4 A;  3SWO A;  4KSF A;  2ZDX A;  3OWM A;  2R0N A;  1XFZ A;  5GJV E;  2JIF A;  2BU2 A;  4JIZ A;  4DZY A;  2C0U A;  1X8Z A;  2LFW A;  3C3L A;  1K90 A;  2FP1 A;  3BNF A;  3SF6 A;  2Q8F A;  2JBR A;  2IX5 A;  1FS9 A;  4IV6 A;  2R02 A;  1R2J A;  2D29 A;  1SK6 A;  3D1I A;  4MPN A;  3GQT A;  4L38 A;  3UBR A;  4FF2 A;  4HKS A;  2PO4 A;  3TZ0 A;  1LVC A;  2ZAF A;  3C46 A;  1X91 A;  2Z1Q A;  3X0X A;  1S26 A;  4DOY A;  4Q0T A;  4Q1O A;  1PK0 A;  5B6B A;  2JBT A;  4KSA A;  3VKG A;  5K3H A;  2EC5 A;  4WJY A;  5M4N A;  2BTZ A;  1RX0 A;  2XS8 A;  2EBA A;  2YYG A;  2REH A;  3TZ4 A;  4OO2 A;  4FF3 A;  2CJ6 A;  5B5V A;  2RDZ A;  2OEX A;  3F29 A;  3R7K A;  4LQQ B;  4KTO A;  2J7A A;  3VAD A;  2ZKJ A;  1U8V A;  4MP2 A;  3CE2 A;  2Q8I A;  4G5E A;  4O5M A;  3LG1 A;  1XFU A;  2E80 A;  1EGC A;  4IRN A;  3U33 A;  4U83 A;  2FP2 A;  3CRK A;  3VKH A;  3X29 A;  1EGE A;  4L3Y A;  4RM7 A;  3UU9 A;  1GKX A;  4E01 A;  2CJ7 A;  5BRK A;  3TZ5 A;  3DJL A;  3SXQ A;  1SIR A;  3X0Y A;  2E0A A;  4JIO A;  4L3X A;  1QDB A;  4Q4U A;  3S7W A;  1IVH A;  4Q17 A;  1OAH A;  1R3B A;  1FS7 A;  3L1T A;  2FON A;  3Q24 A;  2YYL A;  2VR0 A;  4MPC A;  1T9G A;  2BU5 A;  5J6A A;  5M4K A;  3EON A;  4G97 A;  4FF1 A;  1UKW A;  2QR4 A;  1IS2 A;  2DDH A;  3Q22 A;  5K3G A;  1BUC A;  3RKH A;  1GU6 A;  2ZDY A;  4KCF A;  1SC5 A;  3TZ2 A;  5M4M A;  1K8T A;  2PNR A;  4AKG A;  3NF4 A;  3AFE A;  2A1T A;  3D9G A;  3OIB A;  3PFD A;  2OEV A;  1Y8O A;  3HWC A;  4FF4 A;  4H85 A;  2EBH X;  4P79 A;  3Q23 A;  4V25 A;  1X90 A;  2YGW A;  3P4T A;  5J71 A;  2UXW A;  3M9V A;  3C2P A;  3II9 A;  4Q5B A;  3TTB A;  2XS1 A;  1WS9 A;  2OR0 A;  3OWA A;  2R03 A;  3BNH A;  5GJW E;  2OT4 A;  3BNJ A;  3TOR A;  2AZE A;  4V26 A;  3BNG A;  2XQR B;  4HKR A;  4LQS B;  4L1F A;  3FCJ A;  4Q5C A;  4X28 A;  1RJ4 A; 
#chains in the Genus database with same CATH homology
 2RF7 A;  2YYI A;  5K3I A;  2R0M A;  3AFF A;  3D9F A;  4XVX A;  3MPI A;  4M9A A;  3LGQ A;  2WBI A;  3MPJ A;  4ZYJ A;  2YYJ A;  3EOM A;  1W07 A;  4NXL A;  2IX6 A;  2DVL A;  2PG0 A;  4X28 C;  3B96 A;  4P13 A;  3MDE A;  1EGD A;  4HR3 A;  3MDD A;  2YYM A;  3SCE A;  2E81 A;  3MKH A;  4N5F A;  3MMO A;  2CX9 A;  4W9U A;  1UDY A;  3D6B A;  4ZXV A;  3GM6 A;  2VIG A;  4JEK A;  2YYK A;  3D9E A;  1SIQ A;  5K3J A;  3D9D A;  3GNC A;  1JQI A;  3FO3 A;  2JBS A;  2C12 A;  4L3Z A;  3MXL A;  1FS8 A;  2RFQ A;  2ZO5 A;  3SWO A;  3OWM A;  2R0N A;  2JIF A;  2C0U A;  3BNF A;  3SF6 A;  2JBR A;  2IX5 A;  1FS9 A;  4IV6 A;  1R2J A;  2D29 A;  3D1I A;  3UBR A;  3GQT A;  4L38 A;  2ZAF A;  2Z1Q A;  3X0X A;  4DOY A;  4Q0T A;  4Q1O A;  2JBT A;  5K3H A;  4WJY A;  1RX0 A;  2EBA A;  2YYG A;  2REH A;  4OO2 A;  2RDZ A;  3F29 A;  3R7K A;  4KTO A;  2J7A A;  1U8V A;  4G5E A;  4O5M A;  3LG1 A;  2E80 A;  1EGC A;  4IRN A;  4U83 A;  1EGE A;  4L3Y A;  4RM7 A;  3UU9 A;  3SXQ A;  1SIR A;  3X0Y A;  4Q4U A;  3S7W A;  4L3X A;  1QDB A;  1IVH A;  4Q17 A;  1OAH A;  1FS7 A;  3L1T A;  2FON A;  2YYL A;  2VR0 A;  1T9G A;  3EON A;  1UKW A;  1IS2 A;  2DDH A;  5K3G A;  1BUC A;  3RKH A;  1GU6 A;  4KCF A;  3NF4 A;  3AFE A;  2A1T A;  3D9G A;  3OIB A;  3PFD A;  3HWC A;  3P4T A;  2UXW A;  3M9V A;  3II9 A;  4Q5B A;  3TTB A;  1WS9 A;  2OR0 A;  3OWA A;  3BNH A;  2OT4 A;  3TOR A;  3BNJ A;  3BNG A;  4L1F A;  3FCJ A;  4Q5C A;  4X28 A; 
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similar chains in the Genus database (?% sequence similarity)
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