2R0M | Genus

Total Genus 155

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	155
sequence length	390
structure length	390
Chain Sequence	EFDWQDPLVLEEQLTTDEILIRDTFRTYCQERLMPRILLANRNEVFHREIISEMGELGVLGPTIKGYGCAGVSSVAYGLLARELERVDSGYRSAMSVQSSLVMHPIYAYGSEEQRQKYLPQLAKGELLGCFGLTEPNSGSDPSSMETRAHYNSSNKSYTLNGTKTWITNSPMADLFVVWARCEDGCIRGFLLEKGMRGLSAPRIQGKFSLRASATGMIIMDGVEVPEENVLPGASSLGGPFGCLNNARYGIAWGVLGASEFCLHTARQYALDRMQFGVPLARNQLIQKKLADMLTEITLGLHACLQLGRLKDQDKAAPEMVSLLKRNNCGKALDIARQARDMLGGNGISDEYHVIRHAMNLEAVNTYDGTHDIHALILGRAITGIQAFTA

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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reading 390 atoms

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390 atoms created

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Oxidoreductase
source organism	Homo sapiens
publication title	The effect of a Glu370Asp mutation in glutaryl-CoA dehydrogenase on proton transfer to the dienolate intermediate. pubmed doi rcsb
molecule keywords	Glutaryl-CoA dehydrogenase
total genus	155
structure length	390
sequence length	390
ec nomenclature	ec 1.3.8.6: Glutaryl-CoA dehydrogenase (ETF).
pdb deposition date	2007-08-20

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00441	Acyl-CoA_dh_1	Acyl-CoA dehydrogenase, C-terminal domain
A	PF02770	Acyl-CoA_dh_M	Acyl-CoA dehydrogenase, middle domain
A	PF02771	Acyl-CoA_dh_N	Acyl-CoA dehydrogenase, N-terminal domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.540.10	Mainly Alpha	Orthogonal Bundle	Butyryl-Coa Dehydrogenase, subunit A; domain 1	Acyl-CoA dehydrogenase/oxidase, N-terminal domain	2r0mA01
1.20.140.10	Mainly Alpha	Up-down Bundle	Butyryl-CoA Dehydrogenase, subunit A; domain 3	Butyryl-CoA Dehydrogenase, subunit A, domain 3	2r0mA03
2.40.110.10	Mainly Beta	Beta Barrel	Butyryl-CoA Dehydrogenase, subunit A; domain 2	Butyryl-CoA Dehydrogenase, subunit A, domain 2	2r0mA02

3SCEA 3BNHA 4ZYJA 4L3YA 4Q0TA 3MKHA 4ZXVA 3EOMA 5K3IA 3D9FA 3SF6A 2RF7A 3FCJA 2IX6A 4IRNA 1WS9A 3AFEA 3X0XA 1FS7A 1EGCA 4Q17A 4L3ZA 2R0MA 3GQTA 2IX5A 2ZO5A 1JQIA 2EBAA 4L38A 3AFFA 3NF4A 1FS9A 3BNFA 3MPIA 3D6BA 1BUCA 3BNJA 3UBRA 3SWOA 1FS8A 3HWCA 4WJYA 3S7WA 1OAHA 2YYKA 2YYLA 2E80A 2Z1QA 1UDYA 2RDZA 3BNGA 1IVHA 5K3JA 3OWMA 1QDBA 1EGDA 4DOYA 2ZAFA 4N5FA 2CX9A 3II9A 4IV6A 3LG1A 1RX0A 2DDHA 1T9GA 1W07A 4X28A 2J7AA 3PFDA 2JBRA 3MDDA 1R2JA 3UU9A 3MDEA 1U8VA 2DVLA 2RFQA 2REHA 4U83A 2YYIA 2JIFA 4L1FA 4XVXA 4RM7A 1IS2A 3X0YA 2JBTA 4W9UA 1SIRA 4KCFA 4Q5CA 2VIGA 3SXQA 4X28C 3M9VA 3D9DA 3MXLA 2YYJA 2UXWA 3D9EA 3TTBA 3D1IA 4P13A 2R0NA 4JEKA 3B96A 2E81A 4NXLA 4Q4UA 3GNCA 2OR0A 1SIQA 4L3XA 4M9AA 2C0UA 4G5EA 3R7KA 2OT4A 3RKHA 1UKWA 4OO2A 2A1TA 4KTOA 3EONA 2YYGA 2WBIA 1GU6A 3GM6A 1EGEA 4Q5BA 4Q1OA 2JBSA 2YYMA 3TORA 3MMOA 3P4TA 3MPJA 2D29A 3OWAA 4HR3A 2FONA 3L1TA 3D9GA 3FO3A 5K3GA 2VR0A 3F29A 3OIBA 2C12A 4O5MA 3LGQA 5K3HA 2PG0A
chains in the Genus database with same CATH superfamily

2E0AA 1X90A 2QR4A 2AO2A 2ZDYA 3BNHA 4KS9A 3SCEA 4ZYJA 2CJ6A 4L3YA 4Q0TA 2LFWA 1SK6A 4HKRA 3MKHA 4ZXVA 3EOMA 5K3IA 2CJ4A 1S26A 1XFZA 1Y8OA 4V25A 1GKXA 1XFXA 3D9FA 3C3LA 3SF6A 2R05A 4FF1A 4LQSB 2RF7A 3VKGA 1SC5A 3FCJA 2IX6A 4IRNA 1RJ1A 1WS9A 3AFEA 3VADA 3X0XA 1K8TA 5BRKA 1XFWA 1FS7A 1XG2B 1EGCA 4Q17A 4LQQB 5GJWE 2ZDXA 4L3ZA 2R0MA 3GQTA 1R3BA 2IX5A 2ZO5A 1JQIA 2EBAA 1JM6A 4L38A 4QICA 3AFFA 3NF4A 1FS9A 4G97A 3CE2A 3BNFA 4MPCA 3MPIA 1XFUA 3KMLA 3D6BA 4V26A 1BUCA 3BNJA 3UBRA 5M4MA 3SWOA 1FS8A 2F6LA 2CJ8A 4FZ4A 3HWCA 2Q8FA 4E00A 4WJYA 3S7WA 1OAHA 5B5WA 2YYKA 2YYLA 3TZ5A 2E80A 3Q22A 4F0XA 1X8ZA 2BU7A 2Z1QA 4JIZA 1UDYA 1PK0A 2FP2A 2RDZA 3C46A 4AI6A 3N0RA 3BNGA 2EBHX 5M4NA 1IVHA 5K3JA 3OWMA 2Q8IA 1QDBA 2XS8A 4FF2A 1EGDA 3CRKA 4H81A 4DOYA 1GJVA 4H7QA 2ZAFA 2FP1A 4N5FA 2CX9A 3II9A 4IV6A 3LG1A 1RX0A 2DDHA 3TZ0A 1T9GA 5EZ3A 1W07A 4X28A 2J7AA 3PFDA 5B6BA 2JBRA 2HJNA 1XFVA 2R03A 4FF4A 1PI1A 3MDDA 3DJLA 1R2JA 3UU9A 3MDEA 1U8VA 4MPNA 4P79A 2DVLA 1LVCA 2RFQA 2CJ5A 2REHA 1RP3A 4U83A 1Y0VA 2BU5A 2JIFA 2YYIA 4MP2A 4L1FA 3VKHA 4XVXA 4RM7A 1XFYA 1IS2A 2CJ7A 2OJQA 3X0YA 2JBTA 4J1VA 4W9UA 1SIRA 4KCFA 4Q5CA 2VIGA 3D2RA 2Q8GA 4JIOA 3Q0AA 3X29A 3Q24A 2OEXA 3SXQA 4X28C 4E01A 3M9VA 4MP7A 3D9DA 3MXLA 2AZEA 2YYJA 2UXWA 5M4KA 2PNRA 2VF1A 3D9EA 3CRLA 5BRMA 3TTBA 3D1IA 4P13A 3TZ2A 4AKHA 2R0NA 2Q8HA 2BTZA 3U33A 4JEKA 4KSFA 3B96A 2E81A 4NXLA 1X91A 4Q4UA 3GNCA 2OR0A 1SIQA 4L3XA 4E02A 4M9AA 2C0UA 2EC5A 4G5EA 3R7KA 1GKZA 2XS1A 2OT4A 4KSAA 3RKHA 1UKWA 1K90A 2EBFX 4AKIA 1Y8NA 4OO2A 2A1TA 4KTOA 3EONA 2YGWA 2YYGA 5GJVE 2WBIA 1GU6A 3GM6A 1EGEA 4Q5BA 3TZ4A 3C2PA 4Q1OA 2JBSA 2YYMA 2GBBA 3TORA 5J71A 3MMOA 4AKGA 3P4TA 3MPJA 2D29A 3OWAA 1Y8PA 4HR3A 2BU6A 4DZYA 5B5VA 5J6AA 1RJ4A 2FONA 3L1TA 3D9GA 1K93A 2BU8A 2OEVA 3FO3A 4H85A 5M4PA 4FF3A 4MPEA 3Q23A 4HKSA 5K3GA 2PO4A 2VR0A 2R02A 2XQRB 3F29A 3OIBA 2C12A 4O5MA 2BU2A 3LGQA 5K3HA 2PG0A 2ZKJA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 3SCE A;  3BNH A;  4ZYJ A;  4L3Y A;  4Q0T A;  3MKH A;  4ZXV A;  3EOM A;  5K3I A;  3D9F A;  3SF6 A;  2RF7 A;  3FCJ A;  2IX6 A;  4IRN A;  1WS9 A;  3AFE A;  3X0X A;  1FS7 A;  1EGC A;  4Q17 A;  4L3Z A;  2R0M A;  3GQT A;  2IX5 A;  2ZO5 A;  1JQI A;  2EBA A;  4L38 A;  3AFF A;  3NF4 A;  1FS9 A;  3BNF A;  3MPI A;  3D6B A;  1BUC A;  3BNJ A;  3UBR A;  3SWO A;  1FS8 A;  3HWC A;  4WJY A;  3S7W A;  1OAH A;  2YYK A;  2YYL A;  2E80 A;  2Z1Q A;  1UDY A;  2RDZ A;  3BNG A;  1IVH A;  5K3J A;  3OWM A;  1QDB A;  1EGD A;  4DOY A;  2ZAF A;  4N5F A;  2CX9 A;  3II9 A;  4IV6 A;  3LG1 A;  1RX0 A;  2DDH A;  1T9G A;  1W07 A;  4X28 A;  2J7A A;  3PFD A;  2JBR A;  3MDD A;  1R2J A;  3UU9 A;  3MDE A;  1U8V A;  2DVL A;  2RFQ A;  2REH A;  4U83 A;  2YYI A;  2JIF A;  4L1F A;  4XVX A;  4RM7 A;  1IS2 A;  3X0Y A;  2JBT A;  4W9U A;  1SIR A;  4KCF A;  4Q5C A;  2VIG A;  3SXQ A;  4X28 C;  3M9V A;  3D9D A;  3MXL A;  2YYJ A;  2UXW A;  3D9E A;  3TTB A;  3D1I A;  4P13 A;  2R0N A;  4JEK A;  3B96 A;  2E81 A;  4NXL A;  4Q4U A;  3GNC A;  2OR0 A;  1SIQ A;  4L3X A;  4M9A A;  2C0U A;  4G5E A;  3R7K A;  2OT4 A;  3RKH A;  1UKW A;  4OO2 A;  2A1T A;  4KTO A;  3EON A;  2YYG A;  2WBI A;  1GU6 A;  3GM6 A;  1EGE A;  4Q5B A;  4Q1O A;  2JBS A;  2YYM A;  3TOR A;  3MMO A;  3P4T A;  3MPJ A;  2D29 A;  3OWA A;  4HR3 A;  2FON A;  3L1T A;  3D9G A;  3FO3 A;  5K3G A;  2VR0 A;  3F29 A;  3OIB A;  2C12 A;  4O5M A;  3LGQ A;  5K3H A;  2PG0 A; 
#chains in the Genus database with same CATH topology
 2E0A A;  1X90 A;  2QR4 A;  2AO2 A;  2ZDY A;  3BNH A;  4KS9 A;  3SCE A;  4ZYJ A;  2CJ6 A;  4L3Y A;  4Q0T A;  2LFW A;  1SK6 A;  4HKR A;  3MKH A;  4ZXV A;  3EOM A;  5K3I A;  2CJ4 A;  1S26 A;  1XFZ A;  1Y8O A;  4V25 A;  1GKX A;  1XFX A;  3D9F A;  3C3L A;  3SF6 A;  2R05 A;  4FF1 A;  4LQS B;  2RF7 A;  3VKG A;  1SC5 A;  3FCJ A;  2IX6 A;  4IRN A;  1RJ1 A;  1WS9 A;  3AFE A;  3VAD A;  3X0X A;  1K8T A;  5BRK A;  1XFW A;  1FS7 A;  1XG2 B;  1EGC A;  4Q17 A;  4LQQ B;  5GJW E;  2ZDX A;  4L3Z A;  2R0M A;  3GQT A;  1R3B A;  2IX5 A;  2ZO5 A;  1JQI A;  2EBA A;  1JM6 A;  4L38 A;  4QIC A;  3AFF A;  3NF4 A;  1FS9 A;  4G97 A;  3CE2 A;  3BNF A;  4MPC A;  3MPI A;  1XFU A;  3KML A;  3D6B A;  4V26 A;  1BUC A;  3BNJ A;  3UBR A;  5M4M A;  3SWO A;  1FS8 A;  2F6L A;  2CJ8 A;  4FZ4 A;  3HWC A;  2Q8F A;  4E00 A;  4WJY A;  3S7W A;  1OAH A;  5B5W A;  2YYK A;  2YYL A;  3TZ5 A;  2E80 A;  3Q22 A;  4F0X A;  1X8Z A;  2BU7 A;  2Z1Q A;  4JIZ A;  1UDY A;  1PK0 A;  2FP2 A;  2RDZ A;  3C46 A;  4AI6 A;  3N0R A;  3BNG A;  2EBH X;  5M4N A;  1IVH A;  5K3J A;  3OWM A;  2Q8I A;  1QDB A;  2XS8 A;  4FF2 A;  1EGD A;  3CRK A;  4H81 A;  4DOY A;  1GJV A;  4H7Q A;  2ZAF A;  2FP1 A;  4N5F A;  2CX9 A;  3II9 A;  4IV6 A;  3LG1 A;  1RX0 A;  2DDH A;  3TZ0 A;  1T9G A;  5EZ3 A;  1W07 A;  4X28 A;  2J7A A;  3PFD A;  5B6B A;  2JBR A;  2HJN A;  1XFV A;  2R03 A;  4FF4 A;  1PI1 A;  3MDD A;  3DJL A;  1R2J A;  3UU9 A;  3MDE A;  1U8V A;  4MPN A;  4P79 A;  2DVL A;  1LVC A;  2RFQ A;  2CJ5 A;  2REH A;  1RP3 A;  4U83 A;  1Y0V A;  2BU5 A;  2JIF A;  2YYI A;  4MP2 A;  4L1F A;  3VKH A;  4XVX A;  4RM7 A;  1XFY A;  1IS2 A;  2CJ7 A;  2OJQ A;  3X0Y A;  2JBT A;  4J1V A;  4W9U A;  1SIR A;  4KCF A;  4Q5C A;  2VIG A;  3D2R A;  2Q8G A;  4JIO A;  3Q0A A;  3X29 A;  3Q24 A;  2OEX A;  3SXQ A;  4X28 C;  4E01 A;  3M9V A;  4MP7 A;  3D9D A;  3MXL A;  2AZE A;  2YYJ A;  2UXW A;  5M4K A;  2PNR A;  2VF1 A;  3D9E A;  3CRL A;  5BRM A;  3TTB A;  3D1I A;  4P13 A;  3TZ2 A;  4AKH A;  2R0N A;  2Q8H A;  2BTZ A;  3U33 A;  4JEK A;  4KSF A;  3B96 A;  2E81 A;  4NXL A;  1X91 A;  4Q4U A;  3GNC A;  2OR0 A;  1SIQ A;  4L3X A;  4E02 A;  4M9A A;  2C0U A;  2EC5 A;  4G5E A;  3R7K A;  1GKZ A;  2XS1 A;  2OT4 A;  4KSA A;  3RKH A;  1UKW A;  1K90 A;  2EBF X;  4AKI A;  1Y8N A;  4OO2 A;  2A1T A;  4KTO A;  3EON A;  2YGW A;  2YYG A;  5GJV E;  2WBI A;  1GU6 A;  3GM6 A;  1EGE A;  4Q5B A;  3TZ4 A;  3C2P A;  4Q1O A;  2JBS A;  2YYM A;  2GBB A;  3TOR A;  5J71 A;  3MMO A;  4AKG A;  3P4T A;  3MPJ A;  2D29 A;  3OWA A;  1Y8P A;  4HR3 A;  2BU6 A;  4DZY A;  5B5V A;  5J6A A;  1RJ4 A;  2FON A;  3L1T A;  3D9G A;  1K93 A;  2BU8 A;  2OEV A;  3FO3 A;  4H85 A;  5M4P A;  4FF3 A;  4MPE A;  3Q23 A;  4HKS A;  5K3G A;  2PO4 A;  2VR0 A;  2R02 A;  2XQR B;  3F29 A;  3OIB A;  2C12 A;  4O5M A;  2BU2 A;  3LGQ A;  5K3H A;  2PG0 A;  2ZKJ A; 
#chains in the Genus database with same CATH homology
 3SCE A;  3BNH A;  4ZYJ A;  4L3Y A;  4Q0T A;  3MKH A;  4ZXV A;  3EOM A;  5K3I A;  3D9F A;  3SF6 A;  2RF7 A;  3FCJ A;  2IX6 A;  4IRN A;  1WS9 A;  3AFE A;  3X0X A;  1FS7 A;  1EGC A;  4Q17 A;  4L3Z A;  2R0M A;  3GQT A;  2IX5 A;  2ZO5 A;  1JQI A;  2EBA A;  4L38 A;  3AFF A;  3NF4 A;  1FS9 A;  3BNF A;  3MPI A;  3D6B A;  1BUC A;  3BNJ A;  3UBR A;  3SWO A;  1FS8 A;  3HWC A;  4WJY A;  3S7W A;  1OAH A;  2YYK A;  2YYL A;  2E80 A;  2Z1Q A;  1UDY A;  2RDZ A;  3BNG A;  1IVH A;  5K3J A;  3OWM A;  1QDB A;  1EGD A;  4DOY A;  2ZAF A;  4N5F A;  2CX9 A;  3II9 A;  4IV6 A;  3LG1 A;  1RX0 A;  2DDH A;  1T9G A;  1W07 A;  4X28 A;  2J7A A;  3PFD A;  2JBR A;  3MDD A;  1R2J A;  3UU9 A;  3MDE A;  1U8V A;  2DVL A;  2RFQ A;  2REH A;  4U83 A;  2YYI A;  2JIF A;  4L1F A;  4XVX A;  4RM7 A;  1IS2 A;  3X0Y A;  2JBT A;  4W9U A;  1SIR A;  4KCF A;  4Q5C A;  2VIG A;  3SXQ A;  4X28 C;  3M9V A;  3D9D A;  3MXL A;  2YYJ A;  2UXW A;  3D9E A;  3TTB A;  3D1I A;  4P13 A;  2R0N A;  4JEK A;  3B96 A;  2E81 A;  4NXL A;  4Q4U A;  3GNC A;  2OR0 A;  1SIQ A;  4L3X A;  4M9A A;  2C0U A;  4G5E A;  3R7K A;  2OT4 A;  3RKH A;  1UKW A;  4OO2 A;  2A1T A;  4KTO A;  3EON A;  2YYG A;  2WBI A;  1GU6 A;  3GM6 A;  1EGE A;  4Q5B A;  4Q1O A;  2JBS A;  2YYM A;  3TOR A;  3MMO A;  3P4T A;  3MPJ A;  2D29 A;  3OWA A;  4HR3 A;  2FON A;  3L1T A;  3D9G A;  3FO3 A;  5K3G A;  2VR0 A;  3F29 A;  3OIB A;  2C12 A;  4O5M A;  3LGQ A;  5K3H A;  2PG0 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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2R0MA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations