4X28 | Genus

Total Genus 129

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	129
sequence length	373
structure length	364
Chain Sequence	MDFTTTEAAQDLGGLVDTIVDAVCTPEHQRELDKLEQRFDRELWRKLIDAGILSSAAPESLGGDGFGVLEQVAVLVALGHQLAAVPYLESVVLAAGALARFGSPELQQGWGVSAVSGDRILTVALDGEMGEGPVQAAGTGHGYRLTGTRTQVGYGPVADAFLVPAETDSGAAVFLVAAGDPGVAVTALATTGLGSVGHLELNGAKVDAARRVGGTDVAVWLGTLSTLSRTAFQLGVLERGLQMTAEYARTREQFDRPIGSFQAVGQRLADGYIDVKGLRLTLTQAAWRVAEDPADIDVATAGFWAAEAGHRVAHTIVHVHGGVGVDTDHPVHRYFLAAKQTEFALGGATGQLRRIGRELAETPA

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Oxidoreductase
source organism	Mycobacterium tuberculosis (strain atcc 25618 / h37rv)
publication title	Unraveling Cholesterol Catabolism in Mycobacterium tuberculosis: ChsE4-ChsE5 alpha 2 beta 2 Acyl-CoA Dehydrogenase Initiates beta-Oxidation of 3-Oxo-cholest-4-en-26-oyl CoA. pubmed doi rcsb
molecule keywords	Acyl-CoA dehydrogenase
total genus	129
structure length	364
sequence length	373
chains with identical sequence	D
ec nomenclature
pdb deposition date	2014-11-26

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
C	PF00441	Acyl-CoA_dh_1	Acyl-CoA dehydrogenase, C-terminal domain
C	PF02771	Acyl-CoA_dh_N	Acyl-CoA dehydrogenase, N-terminal domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.540.10	Mainly Alpha	Orthogonal Bundle	Butyryl-Coa Dehydrogenase, subunit A; domain 1	Acyl-CoA dehydrogenase/oxidase, N-terminal domain	4x28C01
1.20.140.10	Mainly Alpha	Up-down Bundle	Butyryl-CoA Dehydrogenase, subunit A; domain 3	Butyryl-CoA Dehydrogenase, subunit A, domain 3	4x28C03
2.40.110.10	Mainly Beta	Beta Barrel	Butyryl-CoA Dehydrogenase, subunit A; domain 2	Butyryl-CoA Dehydrogenase, subunit A, domain 2	4x28C02

1RX0A 3MPIA 2D29A 4O5MA 3BNJA 2FONA 1IS2A 3OWMA 5K3JA 4W9UA 2YYGA 4WJYA 1SIQA 1EGEA 3D1IA 3LGQA 2DVLA 4HR3A 2YYJA 2YYLA 3P4TA 4X28C 1FS9A 3MMOA 3BNFA 2IX6A 4L3YA 1W07A 4RM7A 3L1TA 3FO3A 4Q17A 4ZXVA 3D9DA 3EONA 1FS7A 2OT4A 4M9AA 2IX5A 2ZAFA 1U8VA 3R7KA 4Q5CA 2C0UA 3OIBA 3MKHA 1GU6A 4L3ZA 1R2JA 2RFQA 2JBSA 3SWOA 4KCFA 4U83A 3X0XA 2E80A 3NF4A 2JBRA 2DDHA 4NXLA 2CX9A 3RKHA 4P13A 4L3XA 3UU9A 3GQTA 1UDYA 3UBRA 2WBIA 3II9A 4XVXA 3D9EA 3MXLA 3FCJA 4KTOA 1EGCA 3M9VA 2VIGA 2J7AA 2E81A 3F29A 4DOYA 3HWCA 1OAHA 4JEKA 3LG1A 3B96A 4ZYJA 2REHA 2Z1QA 4X28A 2EBAA 1SIRA 3OWAA 3EOMA 4G5EA 2R0MA 4Q5BA 1QDBA 1JQIA 3MDEA 3TTBA 3X0YA 2PG0A 3AFFA 3MPJA 1WS9A 4IRNA 3D9FA 3PFDA 3D6BA 4Q4UA 2RDZA 2ZO5A 5K3IA 3AFEA 4Q1OA 3BNHA 3BNGA 4OO2A 3D9GA 2R0NA 2RF7A 2YYIA 5K3HA 1EGDA 2OR0A 1FS8A 1UKWA 1BUCA 2C12A 2YYMA 2JIFA 1T9GA 4N5FA 3GNCA 2VR0A 3SCEA 3SXQA 4L1FA 2JBTA 4IV6A 5K3GA 1IVHA 3MDDA 4L38A 4Q0TA 2UXWA 3GM6A 3SF6A 3TORA 2YYKA 3S7WA 2A1TA
chains in the Genus database with same CATH superfamily

3TZ5A 1RX0A 4V26A 5M4NA 3MPIA 3Q22A 2LFWA 2D29A 4O5MA 4FF4A 2EBFX 4HKSA 3BNJA 3KMLA 3TZ2A 3X29A 4FF2A 4AKHA 2BU5A 2E0AA 2FONA 1IS2A 3OWMA 5K3JA 1RP3A 4MPEA 4W9UA 3VADA 2YGWA 2YYGA 2FP1A 4WJYA 1SIQA 1EGEA 1GKZA 3D1IA 3LGQA 2DVLA 4HR3A 2YYJA 2YYLA 5GJWE 4H7QA 4MP2A 5B5VA 1PI1A 3P4TA 4X28C 1FS9A 3MMOA 3BNFA 2IX6A 4L3YA 2Q8IA 1W07A 4RM7A 1GKXA 2CJ7A 4FZ4A 2AO2A 2PO4A 2CJ4A 2CJ8A 3L1TA 3FO3A 2EBHX 4Q17A 5J71A 4ZXVA 4LQQB 2R02A 3D9DA 3EONA 1FS7A 2BU8A 4M9AA 2OT4A 1Y8PA 2HJNA 2IX5A 2BTZA 2ZAFA 1U8VA 2BU2A 4V25A 5B6BA 5M4PA 4QICA 3R7KA 4Q5CA 4FF3A 2C0UA 3U33A 2XS1A 3OIBA 4F0XA 1XFYA 3MKHA 1GU6A 4AI6A 4JIZA 4MPCA 4L3ZA 1XFXA 1R2JA 2RFQA 2JBSA 5M4MA 1RJ4A 3SWOA 2EC5A 4KCFA 4U83A 3X0XA 2E80A 3NF4A 2JBRA 2FP2A 2DDHA 4NXLA 2CX9A 3RKHA 4P13A 2PNRA 3VKHA 1SC5A 2BU6A 3CRKA 2Q8FA 3N0RA 5J6AA 1S26A 4L3XA 3UU9A 2ZKJA 3GQTA 4KS9A 3C46A 4J1VA 1UDYA 4HKRA 3UBRA 2WBIA 3II9A 4XVXA 1Y0VA 3D9EA 3MXLA 2CJ6A 1X90A 4LQSB 3FCJA 4KTOA 1GJVA 4KSFA 1EGCA 3M9VA 2OEVA 2AZEA 3D2RA 4JIOA 2VIGA 2J7AA 2R03A 4KSAA 2E81A 2OJQA 2BU7A 3F29A 4DOYA 3HWCA 1OAHA 4JEKA 3LG1A 1XFZA 4MPNA 4DZYA 4E02A 3Q0AA 2QR4A 3B96A 4FF1A 4AKGA 4H81A 4ZYJA 2GBBA 3CE2A 2REHA 2Z1QA 1X91A 2XS8A 4X28A 5BRKA 5EZ3A 2EBAA 1SIRA 3OWAA 2XQRB 3EOMA 4G5EA 2R0MA 5M4KA 4Q5BA 1QDBA 1JQIA 3Q23A 3MDEA 3TTBA 3X0YA 4G97A 3Q24A 1RJ1A 2PG0A 3AFFA 3MPJA 1WS9A 1Y8OA 2OEXA 4IRNA 3D9FA 3PFDA 1JM6A 3D6BA 4P79A 4Q4UA 4AKIA 1K8TA 2RDZA 1LVCA 2ZO5A 5K3IA 3TZ4A 5GJVE 3AFEA 4Q1OA 2F6LA 3BNHA 3BNGA 4OO2A 2VF1A 2CJ5A 3D9GA 2ZDYA 2R0NA 2RF7A 2YYIA 2Q8GA 5K3HA 1EGDA 1X8ZA 2OR0A 1FS8A 1XFWA 1Y8NA 1UKWA 1BUCA 4MP7A 2C12A 2YYMA 2JIFA 1T9GA 1K90A 1R3BA 5B5WA 3C2PA 4N5FA 3GNCA 2VR0A 3SCEA 3SXQA 4E01A 4L1FA 3DJLA 2JBTA 4IV6A 1PK0A 2Q8HA 3CRLA 5BRMA 3TZ0A 3VKGA 5K3GA 1IVHA 3MDDA 2ZDXA 4L38A 3S7WA 4Q0TA 2UXWA 1SK6A 3GM6A 3SF6A 3C3LA 3TORA 2R05A 1XFVA 2YYKA 1XG2B 1XFUA 4E00A 4H85A 1K93A 2A1TA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 1RX0 A;  3MPI A;  2D29 A;  4O5M A;  3BNJ A;  2FON A;  1IS2 A;  3OWM A;  5K3J A;  4W9U A;  2YYG A;  4WJY A;  1SIQ A;  1EGE A;  3D1I A;  3LGQ A;  2DVL A;  4HR3 A;  2YYJ A;  2YYL A;  3P4T A;  4X28 C;  1FS9 A;  3MMO A;  3BNF A;  2IX6 A;  4L3Y A;  1W07 A;  4RM7 A;  3L1T A;  3FO3 A;  4Q17 A;  4ZXV A;  3D9D A;  3EON A;  1FS7 A;  2OT4 A;  4M9A A;  2IX5 A;  2ZAF A;  1U8V A;  3R7K A;  4Q5C A;  2C0U A;  3OIB A;  3MKH A;  1GU6 A;  4L3Z A;  1R2J A;  2RFQ A;  2JBS A;  3SWO A;  4KCF A;  4U83 A;  3X0X A;  2E80 A;  3NF4 A;  2JBR A;  2DDH A;  4NXL A;  2CX9 A;  3RKH A;  4P13 A;  4L3X A;  3UU9 A;  3GQT A;  1UDY A;  3UBR A;  2WBI A;  3II9 A;  4XVX A;  3D9E A;  3MXL A;  3FCJ A;  4KTO A;  1EGC A;  3M9V A;  2VIG A;  2J7A A;  2E81 A;  3F29 A;  4DOY A;  3HWC A;  1OAH A;  4JEK A;  3LG1 A;  3B96 A;  4ZYJ A;  2REH A;  2Z1Q A;  4X28 A;  2EBA A;  1SIR A;  3OWA A;  3EOM A;  4G5E A;  2R0M A;  4Q5B A;  1QDB A;  1JQI A;  3MDE A;  3TTB A;  3X0Y A;  2PG0 A;  3AFF A;  3MPJ A;  1WS9 A;  4IRN A;  3D9F A;  3PFD A;  3D6B A;  4Q4U A;  2RDZ A;  2ZO5 A;  5K3I A;  3AFE A;  4Q1O A;  3BNH A;  3BNG A;  4OO2 A;  3D9G A;  2R0N A;  2RF7 A;  2YYI A;  5K3H A;  1EGD A;  2OR0 A;  1FS8 A;  1UKW A;  1BUC A;  2C12 A;  2YYM A;  2JIF A;  1T9G A;  4N5F A;  3GNC A;  2VR0 A;  3SCE A;  3SXQ A;  4L1F A;  2JBT A;  4IV6 A;  5K3G A;  1IVH A;  3MDD A;  4L38 A;  4Q0T A;  2UXW A;  3GM6 A;  3SF6 A;  3TOR A;  2YYK A;  3S7W A;  2A1T A; 
#chains in the Genus database with same CATH topology
 3TZ5 A;  1RX0 A;  4V26 A;  5M4N A;  3MPI A;  3Q22 A;  2LFW A;  2D29 A;  4O5M A;  4FF4 A;  2EBF X;  4HKS A;  3BNJ A;  3KML A;  3TZ2 A;  3X29 A;  4FF2 A;  4AKH A;  2BU5 A;  2E0A A;  2FON A;  1IS2 A;  3OWM A;  5K3J A;  1RP3 A;  4MPE A;  4W9U A;  3VAD A;  2YGW A;  2YYG A;  2FP1 A;  4WJY A;  1SIQ A;  1EGE A;  1GKZ A;  3D1I A;  3LGQ A;  2DVL A;  4HR3 A;  2YYJ A;  2YYL A;  5GJW E;  4H7Q A;  4MP2 A;  5B5V A;  1PI1 A;  3P4T A;  4X28 C;  1FS9 A;  3MMO A;  3BNF A;  2IX6 A;  4L3Y A;  2Q8I A;  1W07 A;  4RM7 A;  1GKX A;  2CJ7 A;  4FZ4 A;  2AO2 A;  2PO4 A;  2CJ4 A;  2CJ8 A;  3L1T A;  3FO3 A;  2EBH X;  4Q17 A;  5J71 A;  4ZXV A;  4LQQ B;  2R02 A;  3D9D A;  3EON A;  1FS7 A;  2BU8 A;  4M9A A;  2OT4 A;  1Y8P A;  2HJN A;  2IX5 A;  2BTZ A;  2ZAF A;  1U8V A;  2BU2 A;  4V25 A;  5B6B A;  5M4P A;  4QIC A;  3R7K A;  4Q5C A;  4FF3 A;  2C0U A;  3U33 A;  2XS1 A;  3OIB A;  4F0X A;  1XFY A;  3MKH A;  1GU6 A;  4AI6 A;  4JIZ A;  4MPC A;  4L3Z A;  1XFX A;  1R2J A;  2RFQ A;  2JBS A;  5M4M A;  1RJ4 A;  3SWO A;  2EC5 A;  4KCF A;  4U83 A;  3X0X A;  2E80 A;  3NF4 A;  2JBR A;  2FP2 A;  2DDH A;  4NXL A;  2CX9 A;  3RKH A;  4P13 A;  2PNR A;  3VKH A;  1SC5 A;  2BU6 A;  3CRK A;  2Q8F A;  3N0R A;  5J6A A;  1S26 A;  4L3X A;  3UU9 A;  2ZKJ A;  3GQT A;  4KS9 A;  3C46 A;  4J1V A;  1UDY A;  4HKR A;  3UBR A;  2WBI A;  3II9 A;  4XVX A;  1Y0V A;  3D9E A;  3MXL A;  2CJ6 A;  1X90 A;  4LQS B;  3FCJ A;  4KTO A;  1GJV A;  4KSF A;  1EGC A;  3M9V A;  2OEV A;  2AZE A;  3D2R A;  4JIO A;  2VIG A;  2J7A A;  2R03 A;  4KSA A;  2E81 A;  2OJQ A;  2BU7 A;  3F29 A;  4DOY A;  3HWC A;  1OAH A;  4JEK A;  3LG1 A;  1XFZ A;  4MPN A;  4DZY A;  4E02 A;  3Q0A A;  2QR4 A;  3B96 A;  4FF1 A;  4AKG A;  4H81 A;  4ZYJ A;  2GBB A;  3CE2 A;  2REH A;  2Z1Q A;  1X91 A;  2XS8 A;  4X28 A;  5BRK A;  5EZ3 A;  2EBA A;  1SIR A;  3OWA A;  2XQR B;  3EOM A;  4G5E A;  2R0M A;  5M4K A;  4Q5B A;  1QDB A;  1JQI A;  3Q23 A;  3MDE A;  3TTB A;  3X0Y A;  4G97 A;  3Q24 A;  1RJ1 A;  2PG0 A;  3AFF A;  3MPJ A;  1WS9 A;  1Y8O A;  2OEX A;  4IRN A;  3D9F A;  3PFD A;  1JM6 A;  3D6B A;  4P79 A;  4Q4U A;  4AKI A;  1K8T A;  2RDZ A;  1LVC A;  2ZO5 A;  5K3I A;  3TZ4 A;  5GJV E;  3AFE A;  4Q1O A;  2F6L A;  3BNH A;  3BNG A;  4OO2 A;  2VF1 A;  2CJ5 A;  3D9G A;  2ZDY A;  2R0N A;  2RF7 A;  2YYI A;  2Q8G A;  5K3H A;  1EGD A;  1X8Z A;  2OR0 A;  1FS8 A;  1XFW A;  1Y8N A;  1UKW A;  1BUC A;  4MP7 A;  2C12 A;  2YYM A;  2JIF A;  1T9G A;  1K90 A;  1R3B A;  5B5W A;  3C2P A;  4N5F A;  3GNC A;  2VR0 A;  3SCE A;  3SXQ A;  4E01 A;  4L1F A;  3DJL A;  2JBT A;  4IV6 A;  1PK0 A;  2Q8H A;  3CRL A;  5BRM A;  3TZ0 A;  3VKG A;  5K3G A;  1IVH A;  3MDD A;  2ZDX A;  4L38 A;  3S7W A;  4Q0T A;  2UXW A;  1SK6 A;  3GM6 A;  3SF6 A;  3C3L A;  3TOR A;  2R05 A;  1XFV A;  2YYK A;  1XG2 B;  1XFU A;  4E00 A;  4H85 A;  1K93 A;  2A1T A; 
#chains in the Genus database with same CATH homology
 1RX0 A;  3MPI A;  2D29 A;  4O5M A;  3BNJ A;  2FON A;  1IS2 A;  3OWM A;  5K3J A;  4W9U A;  2YYG A;  4WJY A;  1SIQ A;  1EGE A;  3D1I A;  3LGQ A;  2DVL A;  4HR3 A;  2YYJ A;  2YYL A;  3P4T A;  4X28 C;  1FS9 A;  3MMO A;  3BNF A;  2IX6 A;  4L3Y A;  1W07 A;  4RM7 A;  3L1T A;  3FO3 A;  4Q17 A;  4ZXV A;  3D9D A;  3EON A;  1FS7 A;  2OT4 A;  4M9A A;  2IX5 A;  2ZAF A;  1U8V A;  3R7K A;  4Q5C A;  2C0U A;  3OIB A;  3MKH A;  1GU6 A;  4L3Z A;  1R2J A;  2RFQ A;  2JBS A;  3SWO A;  4KCF A;  4U83 A;  3X0X A;  2E80 A;  3NF4 A;  2JBR A;  2DDH A;  4NXL A;  2CX9 A;  3RKH A;  4P13 A;  4L3X A;  3UU9 A;  3GQT A;  1UDY A;  3UBR A;  2WBI A;  3II9 A;  4XVX A;  3D9E A;  3MXL A;  3FCJ A;  4KTO A;  1EGC A;  3M9V A;  2VIG A;  2J7A A;  2E81 A;  3F29 A;  4DOY A;  3HWC A;  1OAH A;  4JEK A;  3LG1 A;  3B96 A;  4ZYJ A;  2REH A;  2Z1Q A;  4X28 A;  2EBA A;  1SIR A;  3OWA A;  3EOM A;  4G5E A;  2R0M A;  4Q5B A;  1QDB A;  1JQI A;  3MDE A;  3TTB A;  3X0Y A;  2PG0 A;  3AFF A;  3MPJ A;  1WS9 A;  4IRN A;  3D9F A;  3PFD A;  3D6B A;  4Q4U A;  2RDZ A;  2ZO5 A;  5K3I A;  3AFE A;  4Q1O A;  3BNH A;  3BNG A;  4OO2 A;  3D9G A;  2R0N A;  2RF7 A;  2YYI A;  5K3H A;  1EGD A;  2OR0 A;  1FS8 A;  1UKW A;  1BUC A;  2C12 A;  2YYM A;  2JIF A;  1T9G A;  4N5F A;  3GNC A;  2VR0 A;  3SCE A;  3SXQ A;  4L1F A;  2JBT A;  4IV6 A;  5K3G A;  1IVH A;  3MDD A;  4L38 A;  4Q0T A;  2UXW A;  3GM6 A;  3SF6 A;  3TOR A;  2YYK A;  3S7W A;  2A1T A;

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similar chains in the Genus database (?% sequence similarity)

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4X28C

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations