1VBIA

Crystal structure of type 2 malate/lactate dehydrogenase from thermus thermophilus hb8
Total Genus 114
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
114
sequence length
340
structure length
340
Chain Sequence
MRWRADFLSAWAEALLRKAGADEPSAKAVAWALVEADLRGVGSHGLLRLPVYVRRLEAGLVNPSPTLPLEERGPVALLDGEHGFGPRVALKAVEAAQSLARRHGLGAVGVRRSTHFGMAGLYAEKLAREGFVAWVTTNAEPDVVPFGGREKALGTNPLAFAAPAPQGILVADLATSESAMGKVFLAREKGERIPPSWGVDREGSPTDDPHRVYALRPLGGPKGYALALLVEVLSGVLTGAGVAHGIGRMYDEWDRPQDVGHFLLALDPGRFVGKEAFLERMGALWQALKATPPAPGHEEVFLPGELEARRRERALAEGMALPERVVAELKALGERYGVPW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of type 2 malate/lactate dehydrogenase from thermus thermophilus HB8
rcsb
molecule tags Oxidoreductase
source organism Thermus thermophilus
molecule keywords Type 2 malate/lactate dehydrogenase
total genus 114
structure length 340
sequence length 340
ec nomenclature ec 1.1.1.27: L-lactate dehydrogenase.
pdb deposition date 2004-02-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02615 Ldh_2 Malate/L-lactate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1530.10 Mainly Alpha Orthogonal Bundle Hypothetical Oxidoreductase Yiak; Chain: A, domain 1 Hypothetical Oxidoreductase Yiak; Chain: A, domain 1 1vbiA01
3.30.1370.60 Alpha Beta 2-Layer Sandwich Ribosomal Protein S8; Chain: A, domain 1 Hypothetical oxidoreductase yiak; domain 2 1vbiA02
3UOEA 4H8AA 4FJSA 1V9NA 1X0AA 1XRHA 1NXUA 1Z2IA 2CWFA 2G8YA 2CWHA 2X06A 1WTJA 3I0PA 4FJUA 1S20A 1VBIA
chains in the Genus database with same CATH superfamily
1X4MA 4DR2H 3KDGA 4IFDG 4LF6H 3GKUA 1IBMH 2G8YA 4NXNH 3L7ZC 3OTOH 1I6UA 2UUCH 2HH3A 1N36H 2CTJA 4FJSA 3FAUA 4LFBH 4GKKH 3KDKA 3JAMW 3OETA 2A1SA 2BA0A 2UUBH 3J7AK 1TUAA 2UXDH 4WALA 1F0XA 2LTLA 2VQEH 5LMUH 2JVZA 2JE6I 4EC5A 2VQFH 4GKJH 1AN7A 4JI0H 2LRRA 2OPUA 1XMOH 4JVYA 1V9NA 1HR0H 2CWFA 3SB1A 1N33H 4BA2I 4JI4H 3AEVB 4JYAH 4DV1H 2QNDA 3UOEA 2ZM6H 2P2RA 2CTMA 2PT7G 1WE8A 4X65H 1N32H 4LF7H 4OX9H 4JI2H 2MJHA 4DUYH 2DGRA 3U1KA 2X06A 3NCVA 4LF9H 5DT9A 5FLXW 3V69A 3EZJA 1HNZH 2UXBH 4DR4H 1ZTGA 4QMFB 1FKAH 1J4WA 4AQYH 2FMRA 4DR7H 4LF5H 4B8TA 4DV3H 4KHPH 3J80W 4NXMH 2JZXA 4OD6A 1Z2IA 4YY3H 2ZQEA 4LIJA 1WTJA 3T1YH 1X4NA 4DR6H 2FFMA 3QD7X 2O4CA 2UXCH 1KHMA 3GABA 4B3RH 2K1HA 4AIMA 4DV4H 3RF2A 1V8CA 2CTFA 2HHHH 2ANNA 1PQXA 1VIHA 4AM3A 2CTKA 4NZRM 4B3MH 1MSZA 1X9ZA 1ZZJA 2CWHA 2LTMA 5JEAG 1HNXH 1FJGH 2AXYA 1XMQH 4JV5H 2NN6G 2D9IA 4JVHA 4DV0H 5LMNH 1ODHA 2CPQA 1EC6A 1N34H 1ZZKA 1DT4A 1SEIA 4B3SH 2LF0A 4PDBA 1VIGA 2PY9A 2F4VH 4JI7H 5A2QW 5IT9W 4JI6H 2JEBI 5LL6b 2M6QA 4OO1G 2PQUA 2JEAI 4DUZH 1UG8A 2JA9A 2M8WA 4JI3H 4B3TH 5BR8H 1J5EH 4JI1H 3VKEA 4DV6H 4LFCH 1XNRH 4K0KH 4WANA 1IBKH 1WVNA 5IWAH 4YHHH 3J81W 1K1GA 1J5KA 4B8CD 1X0AA 1XRHA 4FJUA 3GR5A 4DR3H 1ZZIA 4NBQA 2BL5A 2ANRA 4LF4H 1S20A 2E3UA 2CTEA 4X64H 2FPHX 2E5LH 4DV7H 5K36G 4OCHA 1IBLH 2OPVA 4NZTM 1XNQH 1NXUA 2Y3MA 2HH2A 4BA1I 4DR5H 4JI8H 1DTJA 2YQRA 1VBIA 3OSSD 4DV2H 4LF8H 4DR1H 1S03G 4X66H 4X62H 3I0PA 4DV5H 2UUAH 1HNWH 3T1HH 4H8AA 4G08A 4JI5H 4E9JA 2UU9H 2Z0SA 5C0XG 2CPMA 2CTLA 1I94H 2VKCA 4LFAH 1WHRA
chains in the Genus database with same CATH topology
3UOEA 4H8AA 4FJSA 1V9NA 1X0AA 1XRHA 1NXUA 1Z2IA 2CWFA 2G8YA 2CWHA 2X06A 1WTJA 3I0PA 4FJUA 1S20A 1VBIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3UOE A;  4H8A A;  4FJS A;  1V9N A;  1X0A A;  1XRH A;  1NXU A;  1Z2I A;  2CWF A;  2G8Y A;  2CWH A;  2X06 A;  1WTJ A;  3I0P A;  4FJU A;  1S20 A;  1VBI A; 
#chains in the Genus database with same CATH topology
 1X4M A;  4DR2 H;  3KDG A;  4IFD G;  4LF6 H;  3GKU A;  1IBM H;  2G8Y A;  4NXN H;  3L7Z C;  3OTO H;  1I6U A;  2UUC H;  2HH3 A;  1N36 H;  2CTJ A;  4FJS A;  3FAU A;  4LFB H;  4GKK H;  3KDK A;  3JAM W;  3OET A;  2A1S A;  2BA0 A;  2UUB H;  3J7A K;  1TUA A;  2UXD H;  4WAL A;  1F0X A;  2LTL A;  2VQE H;  5LMU H;  2JVZ A;  2JE6 I;  4EC5 A;  2VQF H;  4GKJ H;  1AN7 A;  4JI0 H;  2LRR A;  2OPU A;  1XMO H;  4JVY A;  1V9N A;  1HR0 H;  2CWF A;  3SB1 A;  1N33 H;  4BA2 I;  4JI4 H;  3AEV B;  4JYA H;  4DV1 H;  2QND A;  3UOE A;  2ZM6 H;  2P2R A;  2CTM A;  2PT7 G;  1WE8 A;  4X65 H;  1N32 H;  4LF7 H;  4OX9 H;  4JI2 H;  2MJH A;  4DUY H;  2DGR A;  3U1K A;  2X06 A;  3NCV A;  4LF9 H;  5DT9 A;  5FLX W;  3V69 A;  3EZJ A;  1HNZ H;  2UXB H;  4DR4 H;  1ZTG A;  4QMF B;  1FKA H;  1J4W A;  4AQY H;  2FMR A;  4DR7 H;  4LF5 H;  4B8T A;  4DV3 H;  4KHP H;  3J80 W;  4NXM H;  2JZX A;  4OD6 A;  1Z2I A;  4YY3 H;  2ZQE A;  4LIJ A;  1WTJ A;  3T1Y H;  1X4N A;  4DR6 H;  2FFM A;  3QD7 X;  2O4C A;  2UXC H;  1KHM A;  3GAB A;  4B3R H;  2K1H A;  4AIM A;  4DV4 H;  3RF2 A;  1V8C A;  2CTF A;  2HHH H;  2ANN A;  1PQX A;  1VIH A;  4AM3 A;  2CTK A;  4NZR M;  4B3M H;  1MSZ A;  1X9Z A;  1ZZJ A;  2CWH A;  2LTM A;  5JEA G;  1HNX H;  1FJG H;  2AXY A;  1XMQ H;  4JV5 H;  2NN6 G;  2D9I A;  4JVH A;  4DV0 H;  5LMN H;  1ODH A;  2CPQ A;  1EC6 A;  1N34 H;  1ZZK A;  1DT4 A;  1SEI A;  4B3S H;  2LF0 A;  4PDB A;  1VIG A;  2PY9 A;  2F4V H;  4JI7 H;  5A2Q W;  5IT9 W;  4JI6 H;  2JEB I;  5LL6 b;  2M6Q A;  4OO1 G;  2PQU A;  2JEA I;  4DUZ H;  1UG8 A;  2JA9 A;  2M8W A;  4JI3 H;  4B3T H;  5BR8 H;  1J5E H;  4JI1 H;  3VKE A;  4DV6 H;  4LFC H;  1XNR H;  4K0K H;  4WAN A;  1IBK H;  1WVN A;  5IWA H;  4YHH H;  3J81 W;  1K1G A;  1J5K A;  4B8C D;  1X0A A;  1XRH A;  4FJU A;  3GR5 A;  4DR3 H;  1ZZI A;  4NBQ A;  2BL5 A;  2ANR A;  4LF4 H;  1S20 A;  2E3U A;  2CTE A;  4X64 H;  2FPH X;  2E5L H;  4DV7 H;  5K36 G;  4OCH A;  1IBL H;  2OPV A;  4NZT M;  1XNQ H;  1NXU A;  2Y3M A;  2HH2 A;  4BA1 I;  4DR5 H;  4JI8 H;  1DTJ A;  2YQR A;  1VBI A;  3OSS D;  4DV2 H;  4LF8 H;  4DR1 H;  1S03 G;  4X66 H;  4X62 H;  3I0P A;  4DV5 H;  2UUA H;  1HNW H;  3T1H H;  4H8A A;  4G08 A;  4JI5 H;  4E9J A;  2UU9 H;  2Z0S A;  5C0X G;  2CPM A;  2CTL A;  1I94 H;  2VKC A;  4LFA H;  1WHR A; 
#chains in the Genus database with same CATH homology
 3UOE A;  4H8A A;  4FJS A;  1V9N A;  1X0A A;  1XRH A;  1NXU A;  1Z2I A;  2CWF A;  2G8Y A;  2CWH A;  2X06 A;  1WTJ A;  3I0P A;  4FJU A;  1S20 A;  1VBI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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