2ANNA

Crystal structure (i) of nova-1 kh1/kh2 domain tandem with 25 nt rna hairpin
Total Genus 41
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
41
sequence length
175
structure length
148
Chain Sequence
GSQYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKDFYPGTTERVCLIQGTIEALNAVHGFIAEKIREMPPDRANQVKIIVPNSTAGLIIGKGGATVKAIMEQSGAWVQLSQNRVVTVSGEPEQNRKAVELIIQKIQEDP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords 5'-R(*CP*GP*CP*GP*CP*GP*GP*AP*UP*CP*AP*GP*UP*CP*AP*CP*CP*CP*
publication title Protein-RNA and protein-protein recognition by dual KH1/2 domains of the neuronal splicing factor Nova-1.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Rna-binding protein/rna
total genus 41
structure length 148
sequence length 175
ec nomenclature
pdb deposition date 2005-08-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00013 KH_1 KH domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1370.10 Alpha Beta 2-Layer Sandwich Ribosomal Protein S8; Chain: A, domain 1 K Homology domain, type 1 2annA01
3.30.1370.10 Alpha Beta 2-Layer Sandwich Ribosomal Protein S8; Chain: A, domain 1 K Homology domain, type 1 2annA02
2CTKA 2JEBI 2OPUA 4NBQA 1ZZJA 1VIHA 1ZZIA 4BA2I 2FMRA 4OO1G 2E3UA 4QMFB 2MJHA 2CTJA 2JEAI 2ANRA 2AXYA 4JVHA 4AM3A 2CTLA 4JVYA 4B8TA 1DTJA 2ANNA 5JEAG 2CTMA 2Z0SA 1DT4A 3VKEA 1J4WA 1ZTGA 2NN6G 1X4NA 2P2RA 2CTFA 2QNDA 3L7ZC 2JZXA 1WE8A 3U1KA 2YQRA 2PQUA 2BA0A 2CTEA 2HH2A 1WVNA 4IFDG 3AEVB 4AIMA 1K1GA 1EC6A 1X4MA 2PY9A 1ZZKA 2JE6I 2OPVA 4WANA 2JVZA 5K36G 2JA9A 5C0XG 3V69A 2CPQA 2BL5A 1KHMA 1J5KA 4LIJA 4WALA 2DGRA 4BA1I 1VIGA 1TUAA 2HH3A
chains in the Genus database with same CATH superfamily
4JI6H 3I0PA 2OPUA 1MSZA 4NBQA 2VQFH 2E5LH 2E3UA 4QMFB 3GKUA 4X65H 4AQYH 1VBIA 2ANRA 2AXYA 4JVYA 1X0AA 5JEAG 4GKKH 1WTJA 4LFAH 4DR3H 4JI8H 2F4VH 5IT9W 4DV0H 4DV6H 3FAUA 2K1HA 3JAMW 2VQEH 3GR5A 4JI4H 4DR5H 3RF2A 2CPMA 1K1GA 4OX9H 1EC6A 2PY9A 1ZZKA 4X64H 2JVZA 5FLXW 3NCVA 5C0XG 4DR1H 1HNXH 1KHMA 1AN7A 4KHPH 1I94H 1J5KA 2LTMA 5BR8H 2ZM6H 4DV3H 2JEBI 4DUZH 1ZZJA 1UG8A 4OO1G 4LF8H 4K0KH 3OTOH 1J5EH 4JVHA 4JI5H 3T1HH 4AM3A 4DR4H 1DTJA 2ANNA 1N36H 3J81W 4LF4H 4JI7H 4LF6H 2Z0SA 1DT4A 4JYAH 3J80W 2CTFA 2ZQEA 2QNDA 1PQXA 1NXUA 1WE8A 1ODHA 4JI0H 2YQRA 2UXCH 1S20A 2G8YA 4EC5A 4JI1H 2UXDH 4X66H 1IBLH 5K36G 2FPHX 3EZJA 2UUCH 4B3SH 2JA9A 4NXNH 2UXBH 4WANA 1X9ZA 2BL5A 1XMOH 1SEIA 4DR2H 4JI2H 4BA1I 4H8AA 2CWHA 2CTKA 1XNQH 1N32H 4FJSA 4LF9H 1ZZIA 1FKAH 2FMRA 4LF7H 1V9NA 2LTLA 5DT9A 1N33H 2CTLA 1HR0H 1FJGH 2CTMA 1V8CA 3KDKA 3VKEA 2NN6G 2PT7G 2LRRA 2JZXA 4DV1H 2UU9H 4DV2H 2M6QA 2PQUA 2BA0A 4B8CD 2CTEA 5A2QW 2A1SA 1WVNA 4YHHH 4JV5H 4OD6A 2CWFA 4AIMA 4DV7H 4NZTM 1XRHA 4B3RH 3V69A 4G08A 3UOEA 5IWAH 4LIJA 4PDBA 1VIGA 1I6UA 3SB1A 2HH3A 1WHRA 3J7AK 4DR6H 4LFBH 3KDGA 3OSSD 1VIHA 2HHHH 4BA2I 2MJHA 2CTJA 4FJUA 4NXMH 1XMQH 2JEAI 4JI3H 4DV5H 4B8TA 3T1YH 2UUAH 4B3MH 4B3TH 5LL6b 2O4CA 1Z2IA 1J4WA 2X06A 1ZTGA 2P2RA 4GKJH 1X4NA 1IBMH 3L7ZC 3QD7X 4OCHA 3U1KA 4E9JA 2LF0A 2Y3MA 2M8WA 4DV4H 4LF5H 4LFCH 1XNRH 2HH2A 4IFDG 1HNZH 4DUYH 3AEVB 1HNWH 1X4MA 1N34H 4DR7H 2JE6I 2OPVA 4NZRM 4YY3H 1F0XA 2FFMA 5LMUH 3GABA 2D9IA 3OETA 2CPQA 2VKCA 5LMNH 1S03G 2UUBH 4WALA 4X62H 2DGRA 1IBKH 1TUAA
chains in the Genus database with same CATH topology
2CTKA 2JEBI 2OPUA 4NBQA 1ZZJA 1VIHA 1ZZIA 4BA2I 2FMRA 4OO1G 2E3UA 4QMFB 2MJHA 2CTJA 2JEAI 2ANRA 2AXYA 4JVHA 4AM3A 2CTLA 4JVYA 4B8TA 1DTJA 2ANNA 5JEAG 2CTMA 2Z0SA 1DT4A 3VKEA 1J4WA 1ZTGA 2NN6G 1X4NA 2P2RA 2CTFA 2QNDA 3L7ZC 2JZXA 1WE8A 3U1KA 2YQRA 2PQUA 2BA0A 2CTEA 2HH2A 1WVNA 4IFDG 3AEVB 4AIMA 1K1GA 1EC6A 1X4MA 2PY9A 1ZZKA 2JE6I 2OPVA 4WANA 2JVZA 5K36G 2JA9A 5C0XG 3V69A 2CPQA 2BL5A 1KHMA 1J5KA 4LIJA 4WALA 2DGRA 4BA1I 1VIGA 1TUAA 2HH3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2CTK A;  2JEB I;  2OPU A;  4NBQ A;  1ZZJ A;  1VIH A;  1ZZI A;  4BA2 I;  2FMR A;  4OO1 G;  2E3U A;  4QMF B;  2MJH A;  2CTJ A;  2JEA I;  2ANR A;  2AXY A;  4JVH A;  4AM3 A;  2CTL A;  4JVY A;  4B8T A;  1DTJ A;  2ANN A;  5JEA G;  2CTM A;  2Z0S A;  1DT4 A;  3VKE A;  1J4W A;  1ZTG A;  2NN6 G;  1X4N A;  2P2R A;  2CTF A;  2QND A;  3L7Z C;  2JZX A;  1WE8 A;  3U1K A;  2YQR A;  2PQU A;  2BA0 A;  2CTE A;  2HH2 A;  1WVN A;  4IFD G;  3AEV B;  4AIM A;  1K1G A;  1EC6 A;  1X4M A;  2PY9 A;  1ZZK A;  2JE6 I;  2OPV A;  4WAN A;  2JVZ A;  5K36 G;  2JA9 A;  5C0X G;  3V69 A;  2CPQ A;  2BL5 A;  1KHM A;  1J5K A;  4LIJ A;  4WAL A;  2DGR A;  4BA1 I;  1VIG A;  1TUA A;  2HH3 A; 
#chains in the Genus database with same CATH topology
 4JI6 H;  3I0P A;  2OPU A;  1MSZ A;  4NBQ A;  2VQF H;  2E5L H;  2E3U A;  4QMF B;  3GKU A;  4X65 H;  4AQY H;  1VBI A;  2ANR A;  2AXY A;  4JVY A;  1X0A A;  5JEA G;  4GKK H;  1WTJ A;  4LFA H;  4DR3 H;  4JI8 H;  2F4V H;  5IT9 W;  4DV0 H;  4DV6 H;  3FAU A;  2K1H A;  3JAM W;  2VQE H;  3GR5 A;  4JI4 H;  4DR5 H;  3RF2 A;  2CPM A;  1K1G A;  4OX9 H;  1EC6 A;  2PY9 A;  1ZZK A;  4X64 H;  2JVZ A;  5FLX W;  3NCV A;  5C0X G;  4DR1 H;  1HNX H;  1KHM A;  1AN7 A;  4KHP H;  1I94 H;  1J5K A;  2LTM A;  5BR8 H;  2ZM6 H;  4DV3 H;  2JEB I;  4DUZ H;  1ZZJ A;  1UG8 A;  4OO1 G;  4LF8 H;  4K0K H;  3OTO H;  1J5E H;  4JVH A;  4JI5 H;  3T1H H;  4AM3 A;  4DR4 H;  1DTJ A;  2ANN A;  1N36 H;  3J81 W;  4LF4 H;  4JI7 H;  4LF6 H;  2Z0S A;  1DT4 A;  4JYA H;  3J80 W;  2CTF A;  2ZQE A;  2QND A;  1PQX A;  1NXU A;  1WE8 A;  1ODH A;  4JI0 H;  2YQR A;  2UXC H;  1S20 A;  2G8Y A;  4EC5 A;  4JI1 H;  2UXD H;  4X66 H;  1IBL H;  5K36 G;  2FPH X;  3EZJ A;  2UUC H;  4B3S H;  2JA9 A;  4NXN H;  2UXB H;  4WAN A;  1X9Z A;  2BL5 A;  1XMO H;  1SEI A;  4DR2 H;  4JI2 H;  4BA1 I;  4H8A A;  2CWH A;  2CTK A;  1XNQ H;  1N32 H;  4FJS A;  4LF9 H;  1ZZI A;  1FKA H;  2FMR A;  4LF7 H;  1V9N A;  2LTL A;  5DT9 A;  1N33 H;  2CTL A;  1HR0 H;  1FJG H;  2CTM A;  1V8C A;  3KDK A;  3VKE A;  2NN6 G;  2PT7 G;  2LRR A;  2JZX A;  4DV1 H;  2UU9 H;  4DV2 H;  2M6Q A;  2PQU A;  2BA0 A;  4B8C D;  2CTE A;  5A2Q W;  2A1S A;  1WVN A;  4YHH H;  4JV5 H;  4OD6 A;  2CWF A;  4AIM A;  4DV7 H;  4NZT M;  1XRH A;  4B3R H;  3V69 A;  4G08 A;  3UOE A;  5IWA H;  4LIJ A;  4PDB A;  1VIG A;  1I6U A;  3SB1 A;  2HH3 A;  1WHR A;  3J7A K;  4DR6 H;  4LFB H;  3KDG A;  3OSS D;  1VIH A;  2HHH H;  4BA2 I;  2MJH A;  2CTJ A;  4FJU A;  4NXM H;  1XMQ H;  2JEA I;  4JI3 H;  4DV5 H;  4B8T A;  3T1Y H;  2UUA H;  4B3M H;  4B3T H;  5LL6 b;  2O4C A;  1Z2I A;  1J4W A;  2X06 A;  1ZTG A;  2P2R A;  4GKJ H;  1X4N A;  1IBM H;  3L7Z C;  3QD7 X;  4OCH A;  3U1K A;  4E9J A;  2LF0 A;  2Y3M A;  2M8W A;  4DV4 H;  4LF5 H;  4LFC H;  1XNR H;  2HH2 A;  4IFD G;  1HNZ H;  4DUY H;  3AEV B;  1HNW H;  1X4M A;  1N34 H;  4DR7 H;  2JE6 I;  2OPV A;  4NZR M;  4YY3 H;  1F0X A;  2FFM A;  5LMU H;  3GAB A;  2D9I A;  3OET A;  2CPQ A;  2VKC A;  5LMN H;  1S03 G;  2UUB H;  4WAL A;  4X62 H;  2DGR A;  1IBK H;  1TUA A; 
#chains in the Genus database with same CATH homology
 2CTK A;  2JEB I;  2OPU A;  4NBQ A;  1ZZJ A;  1VIH A;  1ZZI A;  4BA2 I;  2FMR A;  4OO1 G;  2E3U A;  4QMF B;  2MJH A;  2CTJ A;  2JEA I;  2ANR A;  2AXY A;  4JVH A;  4AM3 A;  2CTL A;  4JVY A;  4B8T A;  1DTJ A;  2ANN A;  5JEA G;  2CTM A;  2Z0S A;  1DT4 A;  3VKE A;  1J4W A;  1ZTG A;  2NN6 G;  1X4N A;  2P2R A;  2CTF A;  2QND A;  3L7Z C;  2JZX A;  1WE8 A;  3U1K A;  2YQR A;  2PQU A;  2BA0 A;  2CTE A;  2HH2 A;  1WVN A;  4IFD G;  3AEV B;  4AIM A;  1K1G A;  1EC6 A;  1X4M A;  2PY9 A;  1ZZK A;  2JE6 I;  2OPV A;  4WAN A;  2JVZ A;  5K36 G;  2JA9 A;  5C0X G;  3V69 A;  2CPQ A;  2BL5 A;  1KHM A;  1J5K A;  4LIJ A;  4WAL A;  2DGR A;  4BA1 I;  1VIG A;  1TUA A;  2HH3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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