1X0A | Genus

Total Genus 115

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	115
sequence length	344
structure length	344
Chain Sequence	MRWRADFLSAWAEALLRKAGADEPSAKAVAWALVEADLRGVGSHGLLRLPVYVRRLEAGLVNPSPTLPLEERGPVALLDGEHGFGPRVALKAVEAAQSLARRHGLGAVGVRRSTHFGMAGLYAEKLAREGFVAWVTTNAEPDVVPFGGREKALGTNPLAFAAPAPQGILVADLATSESAMGKVFLAREKGERIPPSWGVDREGSPTDDPHRVYALRPLGGPKGYALALLVEVLSGVLTGAGVAHGIGRMYDEWDRPQDVGHFLLALDPGRFVGKEAFLERMGALWQALKATPPAPGHEEVFLPGELEARRRERALAEGMALPERVVAELKALGERYGVPWRDDA

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Oxidoreductase
source organism	Thermus thermophilus
publication title	Crystal Structure of type II malate/lactate dehydrogenase from thermus thermophilus HB8 rcsb
molecule keywords	malate/L-lactate dehydrogenase family protein
total genus	115
structure length	344
sequence length	344
ec nomenclature	ec 1.1.1.27: L-lactate dehydrogenase.
pdb deposition date	2005-03-16

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF02615	Ldh_2	Malate/L-lactate dehydrogenase

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.1530.10	Mainly Alpha	Orthogonal Bundle	Hypothetical Oxidoreductase Yiak; Chain: A, domain 1	Hypothetical Oxidoreductase Yiak; Chain: A, domain 1	1x0aA01
3.30.1370.60	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S8; Chain: A, domain 1	Hypothetical oxidoreductase yiak; domain 2	1x0aA02

2X06A 1WTJA 1X0AA 4FJUA 1V9NA 2G8YA 2CWFA 1Z2IA 1S20A 1VBIA 1XRHA 2CWHA 4H8AA 1NXUA 4FJSA 3I0PA 3UOEA
chains in the Genus database with same CATH superfamily

4B3TH 1MSZA 4JI1H 4JI0H 2UXDH 3J81W 2HH2A 1IBMH 1WHRA 1ZZKA 2A1SA 3OTOH 3EZJA 2ZQEA 2VQFH 2LF0A 1X0AA 1V9NA 2MJHA 1IBKH 4BA2I 1EC6A 4OX9H 1I6UA 1X4MA 3GKUA 2CTMA 3V69A 4B8TA 2UU9H 2PT7G 3KDGA 3SB1A 1WE8A 1X9ZA 2YQRA 1N34H 1ZTGA 2PY9A 2X06A 2DGRA 4E9JA 2PQUA 4LIJA 4DR2H 4K0KH 2FFMA 4JI4H 2FMRA 2JZXA 3GABA 4G08A 4GKKH 5DT9A 1WTJA 2JA9A 5IWAH 3OSSD 4FJUA 1WVNA 2FPHX 5JEAG 4NXNH 4DV1H 1I94H 4JV5H 1S03G 4X64H 1N36H 1VIGA 2OPVA 4AIMA 2JEBI 3J80W 1HNZH 4JVHA 4DR7H 1N32H 4DV2H 4JI7H 4YHHH 2UXCH 4FJSA 2CTEA 2LRRA 5LMNH 3UOEA 1K1GA 2M8WA 2QNDA 1ODHA 5C0XG 4WANA 4LF4H 4DV0H 4B3RH 1KHMA 4DR3H 1NXUA 1DTJA 4NZTM 1N33H 4OO1G 4DV3H 1PQXA 4B3MH 4DR1H 2G8YA 2CTFA 3NCVA 3OETA 1Z2IA 1S20A 1AN7A 4JI2H 3L7ZC 4DUYH 1SEIA 2D9IA 4YY3H 4DUZH 4H8AA 4OCHA 2HHHH 2UUBH 4NXMH 3VKEA 4DR5H 4LFAH 1DT4A 5FLXW 2F4VH 2ANRA 4DR4H 4LFBH 2Y3MA 4OD6A 3U1KA 2OPUA 4JI6H 2CPQA 2M6QA 4JI8H 4LF7H 1IBLH 4QMFB 4LF6H 2VQEH 3T1HH 3T1YH 1HR0H 4PDBA 4AM3A 4WALA 2UUCH 1XRHA 3AEVB 4EC5A 1TUAA 4B8CD 4LF8H 1XNRH 4X65H 2UXBH 2BA0A 4X66H 2CWFA 1UG8A 4DV7H 4X62H 2CTKA 2BL5A 1FJGH 4JI3H 2E3UA 1HNWH 3RF2A 3KDKA 2JVZA 2AXYA 1HNXH 2Z0SA 2O4CA 2E5LH 3J7AK 4LF9H 2UUAH 1FKAH 5A2QW 2P2RA 4NZRM 4B3SH 2ANNA 2NN6G 2LTLA 4LFCH 1V8CA 1F0XA 1XMOH 3I0PA 4JI5H 2VKCA 1ZZJA 2CPMA 5LMUH 3QD7X 1XMQH 1J4WA 2JEAI 1VBIA 4DV4H 4IFDG 2HH3A 5K36G 2CWHA 2K1HA 2CTLA 5LL6b 2JE6I 1J5KA 2CTJA 4KHPH 3FAUA 3GR5A 4DR6H 4JVYA 4BA1I 4DV6H 1ZZIA 1J5EH 4DV5H 2LTMA 5BR8H 4GKJH 5IT9W 2ZM6H 1X4NA 3JAMW 4AQYH 4LF5H 4NBQA 1VIHA 4JYAH 1XNQH
chains in the Genus database with same CATH topology

2X06A 1WTJA 1X0AA 4FJUA 1V9NA 2G8YA 2CWFA 1Z2IA 1S20A 1VBIA 1XRHA 2CWHA 4H8AA 1NXUA 4FJSA 3I0PA 3UOEA
chains in the Genus database with same CATH homology

#chains in the Genus database with same CATH superfamily
 2X06 A;  1WTJ A;  1X0A A;  4FJU A;  1V9N A;  2G8Y A;  2CWF A;  1Z2I A;  1S20 A;  1VBI A;  1XRH A;  2CWH A;  4H8A A;  1NXU A;  4FJS A;  3I0P A;  3UOE A; 
#chains in the Genus database with same CATH topology
 4B3T H;  1MSZ A;  4JI1 H;  4JI0 H;  2UXD H;  3J81 W;  2HH2 A;  1IBM H;  1WHR A;  1ZZK A;  2A1S A;  3OTO H;  3EZJ A;  2ZQE A;  2VQF H;  2LF0 A;  1X0A A;  1V9N A;  2MJH A;  1IBK H;  4BA2 I;  1EC6 A;  4OX9 H;  1I6U A;  1X4M A;  3GKU A;  2CTM A;  3V69 A;  4B8T A;  2UU9 H;  2PT7 G;  3KDG A;  3SB1 A;  1WE8 A;  1X9Z A;  2YQR A;  1N34 H;  1ZTG A;  2PY9 A;  2X06 A;  2DGR A;  4E9J A;  2PQU A;  4LIJ A;  4DR2 H;  4K0K H;  2FFM A;  4JI4 H;  2FMR A;  2JZX A;  3GAB A;  4G08 A;  4GKK H;  5DT9 A;  1WTJ A;  2JA9 A;  5IWA H;  3OSS D;  4FJU A;  1WVN A;  2FPH X;  5JEA G;  4NXN H;  4DV1 H;  1I94 H;  4JV5 H;  1S03 G;  4X64 H;  1N36 H;  1VIG A;  2OPV A;  4AIM A;  2JEB I;  3J80 W;  1HNZ H;  4JVH A;  4DR7 H;  1N32 H;  4DV2 H;  4JI7 H;  4YHH H;  2UXC H;  4FJS A;  2CTE A;  2LRR A;  5LMN H;  3UOE A;  1K1G A;  2M8W A;  2QND A;  1ODH A;  5C0X G;  4WAN A;  4LF4 H;  4DV0 H;  4B3R H;  1KHM A;  4DR3 H;  1NXU A;  1DTJ A;  4NZT M;  1N33 H;  4OO1 G;  4DV3 H;  1PQX A;  4B3M H;  4DR1 H;  2G8Y A;  2CTF A;  3NCV A;  3OET A;  1Z2I A;  1S20 A;  1AN7 A;  4JI2 H;  3L7Z C;  4DUY H;  1SEI A;  2D9I A;  4YY3 H;  4DUZ H;  4H8A A;  4OCH A;  2HHH H;  2UUB H;  4NXM H;  3VKE A;  4DR5 H;  4LFA H;  1DT4 A;  5FLX W;  2F4V H;  2ANR A;  4DR4 H;  4LFB H;  2Y3M A;  4OD6 A;  3U1K A;  2OPU A;  4JI6 H;  2CPQ A;  2M6Q A;  4JI8 H;  4LF7 H;  1IBL H;  4QMF B;  4LF6 H;  2VQE H;  3T1H H;  3T1Y H;  1HR0 H;  4PDB A;  4AM3 A;  4WAL A;  2UUC H;  1XRH A;  3AEV B;  4EC5 A;  1TUA A;  4B8C D;  4LF8 H;  1XNR H;  4X65 H;  2UXB H;  2BA0 A;  4X66 H;  2CWF A;  1UG8 A;  4DV7 H;  4X62 H;  2CTK A;  2BL5 A;  1FJG H;  4JI3 H;  2E3U A;  1HNW H;  3RF2 A;  3KDK A;  2JVZ A;  2AXY A;  1HNX H;  2Z0S A;  2O4C A;  2E5L H;  3J7A K;  4LF9 H;  2UUA H;  1FKA H;  5A2Q W;  2P2R A;  4NZR M;  4B3S H;  2ANN A;  2NN6 G;  2LTL A;  4LFC H;  1V8C A;  1F0X A;  1XMO H;  3I0P A;  4JI5 H;  2VKC A;  1ZZJ A;  2CPM A;  5LMU H;  3QD7 X;  1XMQ H;  1J4W A;  2JEA I;  1VBI A;  4DV4 H;  4IFD G;  2HH3 A;  5K36 G;  2CWH A;  2K1H A;  2CTL A;  5LL6 b;  2JE6 I;  1J5K A;  2CTJ A;  4KHP H;  3FAU A;  3GR5 A;  4DR6 H;  4JVY A;  4BA1 I;  4DV6 H;  1ZZI A;  1J5E H;  4DV5 H;  2LTM A;  5BR8 H;  4GKJ H;  5IT9 W;  2ZM6 H;  1X4N A;  3JAM W;  4AQY H;  4LF5 H;  4NBQ A;  1VIH A;  4JYA H;  1XNQ H; 
#chains in the Genus database with same CATH homology
 2X06 A;  1WTJ A;  1X0A A;  4FJU A;  1V9N A;  2G8Y A;  2CWF A;  1Z2I A;  1S20 A;  1VBI A;  1XRH A;  2CWH A;  4H8A A;  1NXU A;  4FJS A;  3I0P A;  3UOE A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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1X0AA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations