1X0AA

Crystal structure of type ii malate/lactate dehydrogenase from thermus thermophilus hb8
Total Genus 115
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
115
sequence length
344
structure length
344
Chain Sequence
MRWRADFLSAWAEALLRKAGADEPSAKAVAWALVEADLRGVGSHGLLRLPVYVRRLEAGLVNPSPTLPLEERGPVALLDGEHGFGPRVALKAVEAAQSLARRHGLGAVGVRRSTHFGMAGLYAEKLAREGFVAWVTTNAEPDVVPFGGREKALGTNPLAFAAPAPQGILVADLATSESAMGKVFLAREKGERIPPSWGVDREGSPTDDPHRVYALRPLGGPKGYALALLVEVLSGVLTGAGVAHGIGRMYDEWDRPQDVGHFLLALDPGRFVGKEAFLERMGALWQALKATPPAPGHEEVFLPGELEARRRERALAEGMALPERVVAELKALGERYGVPWRDDA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of type II malate/lactate dehydrogenase from thermus thermophilus HB8
rcsb
molecule tags Oxidoreductase
source organism Thermus thermophilus
molecule keywords malate/L-lactate dehydrogenase family protein
total genus 115
structure length 344
sequence length 344
ec nomenclature ec 1.1.1.27: L-lactate dehydrogenase.
pdb deposition date 2005-03-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02615 Ldh_2 Malate/L-lactate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1530.10 Mainly Alpha Orthogonal Bundle Hypothetical Oxidoreductase Yiak; Chain: A, domain 1 Hypothetical Oxidoreductase Yiak; Chain: A, domain 1 1x0aA01
3.30.1370.60 Alpha Beta 2-Layer Sandwich Ribosomal Protein S8; Chain: A, domain 1 Hypothetical oxidoreductase yiak; domain 2 1x0aA02
2CWFA 4H8AA 3UOEA 1X0AA 1XRHA 1V9NA 1WTJA 4FJSA 1S20A 2G8YA 3I0PA 1VBIA 1Z2IA 1NXUA 2X06A 2CWHA 4FJUA
chains in the Genus database with same CATH superfamily
1F0XA 3OSSD 3J7AK 3I0PA 2UUAH 1K1GA 1XNQH 3U1KA 3OETA 2CWFA 2OPUA 4DR1H 2LF0A 2CTLA 2HH3A 1XMOH 1I94H 2UUBH 4B8TA 4KHPH 2FFMA 4NXNH 4LF9H 2JA9A 5BR8H 4JI6H 2ZQEA 4FJSA 2JZXA 4JI5H 4BA2I 5K36G 2M6QA 2ZM6H 2P2RA 3AEVB 4B8CD 1J4WA 1IBKH 4FJUA 4X64H 1N36H 2E3UA 3RF2A 1X0AA 1XRHA 1V9NA 2CTMA 4X65H 1SEIA 4B3MH 4LFCH 1HNXH 2O4CA 4OX9H 2JEAI 2CTKA 4JI8H 4DV4H 4DR3H 4JI1H 1PQXA 4JI0H 1N33H 1X9ZA 5FLXW 4DV7H 2DGRA 4GKJH 4LF7H 3NCVA 3KDGA 4B3SH 2A1SA 1KHMA 3FAUA 4NZRM 4LF8H 4DR7H 4OD6A 1N34H 4IFDG 2VQEH 2CWHA 3T1YH 1TUAA 1ZZJA 2UXBH 1AN7A 4JVYA 4JI4H 1MSZA 2YQRA 1S03G 2F4VH 3KDKA 2MJHA 2UXCH 1WHRA 4YY3H 2ANNA 1XMQH 3UOEA 2JVZA 4AQYH 3J80W 2ANRA 4BA1I 1HNZH 4EC5A 2NN6G 2UUCH 2PT7G 2JE6I 4PDBA 1DT4A 1FKAH 1FJGH 1WTJA 4LFAH 2M8WA 2AXYA 3VKEA 2CTJA 4DV5H 4DR5H 1UG8A 4G08A 2BL5A 1HR0H 5DT9A 1VIGA 4LIJA 4WALA 2LRRA 2K1HA 2HHHH 4DR4H 5LL6b 1ZZKA 1HNWH 4DV0H 3GR5A 1ODHA 1Z2IA 1VIHA 2FMRA 2X06A 2LTLA 4NZTM 5LMNH 1I6UA 4JVHA 2LTMA 4DUZH 1DTJA 1X4MA 5JEAG 4JV5H 4DR2H 1N32H 2VKCA 1ZTGA 1NXUA 2QNDA 4QMFB 4B3TH 1EC6A 2CTFA 1WVNA 2UXDH 3OTOH 1J5EH 4JI2H 2D9IA 2Y3MA 1X4NA 2UU9H 1XNRH 4X62H 4AM3A 4OO1G 1V8CA 4H8AA 4JI7H 1IBMH 3SB1A 3J81W 3T1HH 4LF6H 3GABA 4AIMA 1VBIA 2BA0A 5IWAH 4JI3H 2CPQA 4K0KH 1J5KA 4E9JA 3QD7X 2JEBI 2PQUA 4LFBH 4DV6H 5IT9W 2CPMA 1S20A 3JAMW 4X66H 4DUYH 4JYAH 4NXMH 2CTEA 3V69A 4DR6H 4GKKH 3L7ZC 4YHHH 3EZJA 2OPVA 4DV2H 2E5LH 5C0XG 4LF4H 2PY9A 1WE8A 4LF5H 4DV3H 4WANA 1IBLH 3GKUA 2Z0SA 4B3RH 5LMUH 4DV1H 2G8YA 5A2QW 2HH2A 4OCHA 2FPHX 4NBQA 1ZZIA 2VQFH
chains in the Genus database with same CATH topology
2CWFA 4H8AA 3UOEA 1X0AA 1XRHA 1V9NA 1WTJA 4FJSA 1S20A 2G8YA 3I0PA 1VBIA 1Z2IA 1NXUA 2X06A 2CWHA 4FJUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2CWF A;  4H8A A;  3UOE A;  1X0A A;  1XRH A;  1V9N A;  1WTJ A;  4FJS A;  1S20 A;  2G8Y A;  3I0P A;  1VBI A;  1Z2I A;  1NXU A;  2X06 A;  2CWH A;  4FJU A; 
#chains in the Genus database with same CATH topology
 1F0X A;  3OSS D;  3J7A K;  3I0P A;  2UUA H;  1K1G A;  1XNQ H;  3U1K A;  3OET A;  2CWF A;  2OPU A;  4DR1 H;  2LF0 A;  2CTL A;  2HH3 A;  1XMO H;  1I94 H;  2UUB H;  4B8T A;  4KHP H;  2FFM A;  4NXN H;  4LF9 H;  2JA9 A;  5BR8 H;  4JI6 H;  2ZQE A;  4FJS A;  2JZX A;  4JI5 H;  4BA2 I;  5K36 G;  2M6Q A;  2ZM6 H;  2P2R A;  3AEV B;  4B8C D;  1J4W A;  1IBK H;  4FJU A;  4X64 H;  1N36 H;  2E3U A;  3RF2 A;  1X0A A;  1XRH A;  1V9N A;  2CTM A;  4X65 H;  1SEI A;  4B3M H;  4LFC H;  1HNX H;  2O4C A;  4OX9 H;  2JEA I;  2CTK A;  4JI8 H;  4DV4 H;  4DR3 H;  4JI1 H;  1PQX A;  4JI0 H;  1N33 H;  1X9Z A;  5FLX W;  4DV7 H;  2DGR A;  4GKJ H;  4LF7 H;  3NCV A;  3KDG A;  4B3S H;  2A1S A;  1KHM A;  3FAU A;  4NZR M;  4LF8 H;  4DR7 H;  4OD6 A;  1N34 H;  4IFD G;  2VQE H;  2CWH A;  3T1Y H;  1TUA A;  1ZZJ A;  2UXB H;  1AN7 A;  4JVY A;  4JI4 H;  1MSZ A;  2YQR A;  1S03 G;  2F4V H;  3KDK A;  2MJH A;  2UXC H;  1WHR A;  4YY3 H;  2ANN A;  1XMQ H;  3UOE A;  2JVZ A;  4AQY H;  3J80 W;  2ANR A;  4BA1 I;  1HNZ H;  4EC5 A;  2NN6 G;  2UUC H;  2PT7 G;  2JE6 I;  4PDB A;  1DT4 A;  1FKA H;  1FJG H;  1WTJ A;  4LFA H;  2M8W A;  2AXY A;  3VKE A;  2CTJ A;  4DV5 H;  4DR5 H;  1UG8 A;  4G08 A;  2BL5 A;  1HR0 H;  5DT9 A;  1VIG A;  4LIJ A;  4WAL A;  2LRR A;  2K1H A;  2HHH H;  4DR4 H;  5LL6 b;  1ZZK A;  1HNW H;  4DV0 H;  3GR5 A;  1ODH A;  1Z2I A;  1VIH A;  2FMR A;  2X06 A;  2LTL A;  4NZT M;  5LMN H;  1I6U A;  4JVH A;  2LTM A;  4DUZ H;  1DTJ A;  1X4M A;  5JEA G;  4JV5 H;  4DR2 H;  1N32 H;  2VKC A;  1ZTG A;  1NXU A;  2QND A;  4QMF B;  4B3T H;  1EC6 A;  2CTF A;  1WVN A;  2UXD H;  3OTO H;  1J5E H;  4JI2 H;  2D9I A;  2Y3M A;  1X4N A;  2UU9 H;  1XNR H;  4X62 H;  4AM3 A;  4OO1 G;  1V8C A;  4H8A A;  4JI7 H;  1IBM H;  3SB1 A;  3J81 W;  3T1H H;  4LF6 H;  3GAB A;  4AIM A;  1VBI A;  2BA0 A;  5IWA H;  4JI3 H;  2CPQ A;  4K0K H;  1J5K A;  4E9J A;  3QD7 X;  2JEB I;  2PQU A;  4LFB H;  4DV6 H;  5IT9 W;  2CPM A;  1S20 A;  3JAM W;  4X66 H;  4DUY H;  4JYA H;  4NXM H;  2CTE A;  3V69 A;  4DR6 H;  4GKK H;  3L7Z C;  4YHH H;  3EZJ A;  2OPV A;  4DV2 H;  2E5L H;  5C0X G;  4LF4 H;  2PY9 A;  1WE8 A;  4LF5 H;  4DV3 H;  4WAN A;  1IBL H;  3GKU A;  2Z0S A;  4B3R H;  5LMU H;  4DV1 H;  2G8Y A;  5A2Q W;  2HH2 A;  4OCH A;  2FPH X;  4NBQ A;  1ZZI A;  2VQF H; 
#chains in the Genus database with same CATH homology
 2CWF A;  4H8A A;  3UOE A;  1X0A A;  1XRH A;  1V9N A;  1WTJ A;  4FJS A;  1S20 A;  2G8Y A;  3I0P A;  1VBI A;  1Z2I A;  1NXU A;  2X06 A;  2CWH A;  4FJU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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