1I19 | Genus

Total Genus 179

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	179
sequence length	557
structure length	541
Chain Sequence	VAPLPTPPNFPNDIALFQQAYQNWSKEIMLDATWVCSPKTPQDVVRLANWAHEHDYKIRPRGAMHGWTPLTVEKGANVEKVILADTMTHLNGITVNTGGPVATVTAGAGASIEAIVTELQKHDLGWANLPAPGVLSIGGALAVNAHGAALPAVGQTTLPGHTYGSLSNLVTELTAVVWNGTTYALETYQRNDPRITPLLTNLGRCFLTSVTMQAGPNFRQRCQSYTDIPWRELFAPKGADGRTFEKFVAESGGAEAIWYPFTEKPWMKVWTVSPSLVGKPPQAREVSGPYNYIFSDNLPEPITDMIGAINAGNPGIAPLFGPAMYEITKLGLAATNANDIWGWSKDVQFYIKATTLRLTEGGGAVVTSRANIATVINDFTEWFHERIEFYRAKGEFPLNGPVEIRCCGLDQAADVKVPSVGPPTISATRPRPDHPDWDVAIWLNVLGVPGTPGMFEFYREMEQWMRSHYNNDDATFRPEWSKGWAFGPDPYTDNDIVTNKMRATYIEGVPTTENWDTARARYNQIDPHRVFTNGFMDKLLP

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Oxidoreductase
source organism	Brevibacterium sterolicum
publication title	Oxygen access to the active site of cholesterol oxidase through a narrow channel is gated by an Arg-Glu pair. pubmed doi rcsb
molecule keywords	CHOLESTEROL OXIDASE
total genus	179
structure length	541
sequence length	557
chains with identical sequence	B
ec nomenclature	ec 1.1.3.6: Cholesterol oxidase.
pdb deposition date	2001-01-31

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF01565	FAD_binding_4	FAD binding domain
A	PF09129	Chol_subst-bind	Cholesterol oxidase, substrate-binding

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.45.10	Mainly Alpha	Orthogonal Bundle	Vanillyl-alcohol Oxidase; Chain A, domain 4	Vanillyl-alcohol Oxidase; Chain A, domain 4	1i19A04
3.30.43.10	Alpha Beta	2-Layer Sandwich	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2	1i19A01
3.30.465.10	Alpha Beta	2-Layer Sandwich	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3	1i19A02
3.40.462.10	Alpha Beta	3-Layer(aba) Sandwich	Vanillyl-alcohol Oxidase; Chain A, domain 3	FAD-linked oxidases, C-terminal domain	1i19A03

2VAOA 5HMRA 3NVVB 3HRDC 1W1RA 1FFUC 2VFRA 3PM9A 3FW7A 5FXFA 5FXEA 2P4PA 1W1JA 5G5GB 3D2JA 1I19A 4PVKA 3LAEA 1JROA 3SR6B 1VDVA 3AMZA 1F0XA 1W1KA 4ZOHB 4PWCA 1E0YA 3DQ0A 2P3HA 1E8HA 1WVFA 1FIQB 3VTEA 1W1SA 2OAIA 2VFUA 4OALA 2BVFA 2R8DA 3S1EA 3TX1A 5AE1A 4BC9A 3NRZB 2RK5A 3BW7A 3S1CA 1N5XA 1W1LA 1DIQA 3TSHA 3EUB3 5G5HB 1MBTA 3AN1A 1AHUA 2W55A 3B9JB 4PYTA 4EC3A 2O3GA 1ZR6A 3NVWB 2QKNA 3D2DA 3FW8A 3TSJA 2YVSA 1N63C 1DIIA 1N61C 3FW9A 2VFTA 2GQUA 3AM9A 2AXRA 4PVEA 1N62C 2E3TA 4PWBA 2W54A 5HHZA 1SB3B 1WVEA 4JB1A 1E8FA 4UD8A 2BVGA 1AHZA 2MBRA 4BBYA 2W3SA 1QLUA 3W8XA 5AE3A 1AHVA 4JAYA 1FO4A 5HQXA 1W1OA 3FWAA 2NQWA 5ADZA 1UXYA 1V97A 4O95A 3GSYA 2BVHA 1MBBA 1T3QC 4DNSA 1E8GA 2PLSA 3LLBA 4HG0A 4PZFA 4PVJA 3D2HA 1VAOA 3JS8A 1JRPA 2R2ZA 3C0PA 4BC7A 2QPMA 3NVZB 3S1FA 4PVHA 3W8WA 3NS1B 4XLOA 1W1MA 3W8ZA 1DZNA 2I0KA 2W3RA 1N60C 1N5WC 5FXDA 3KJMA 3ETRB 1ZXIC 4MLAA 5FXPA 2Q85A 1QLTA 1FFVC 2GQTA 3DEDA 5AE2A 1WYGA 2P13A 3I99A 2VFSA 4BCAA 3NVYB 4ML8A 1W1QA 5D79A 2PLIA 1RM6B 2Q4WA 3S1DA 2EXRA 2VFVA 1HSKA
chains in the Genus database with same CATH superfamily

5L6GA 2VAOA 5HMRA 3NVVB 3HRDC 1W1RA 1FFUC 2VFRA 3PM9A 3FW7A 5FXFA 5FXEA 2P4PA 1W1JA 5G5GB 3D2JA 1I19A 4PVKA 3LAEA 1JROA 3SR6B 1VDVA 3AMZA 2Y4GA 1F0XA 1W1KA 4ZOHB 4PWCA 1E0YA 3DQ0A 2P3HA 1E8HA 1WVFA 1FIQB 3VTEA 1W1SA 5I1VA 2WDWA 2OAIA 2VFUA 4OALA 2BVFA 2R8DA 3S1EA 3TX1A 5AE1A 4BC9A 3NRZB 3RJAA 2RK5A 3BW7A 3S1CA 1N5XA 1W1LA 1DIQA 3TSHA 3EUB3 5G5HB 1MBTA 3AN1A 1AHUA 2W55A 3B9JB 4PYTA 4EC3A 2O3GA 2UUUA 1ZR6A 3NVWB 2QKNA 3D2DA 3FW8A 3EJDB 3TSJA 2YVSA 1N63C 2Y08A 1DIIA 1N61C 3FW9A 5AWVA 2VFTA 2GQUA 3EJEB 5L6FA 3AM9A 2AXRA 4PVEA 2Y3RA 1N62C 2E3TA 4PWBA 2W54A 5HHZA 1SB3B 1WVEA 4JB1A 1E8FA 4UD8A 2BVGA 1AHZA 2MBRA 4BBYA 2W3SA 1QLUA 3W8XA 5AE3A 3POPA 1AHVA 4JAYA 1FO4A 5HQXA 1W1OA 3FWAA 2NQWA 5ADZA 1UXYA 1V97A 3PQBA 4O95A 3GSYA 2BVHA 1MBBA 1T3QC 4DNSA 1E8GA 2PLSA 3LLBA 4HG0A 4PZFA 4PVJA 3D2HA 1VAOA 3JS8A 3HSUA 1JRPA 3EJBB 2R2ZA 3C0PA 5I1WA 4BC7A 2QPMA 2Y3SA 3NVZB 3S1FA 4PVHA 3W8WA 3NS1B 4XLOA 3RJ8A 5K8EA 1W1MA 3W8ZA 1DZNA 2I0KA 2W3RA 1N60C 1N5WC 5FXDA 3KJMA 3ETRB 1ZXIC 4MLAA 5FXPA 2Q85A 1QLTA 1FFVC 2GQTA 3DEDA 5AE2A 2IPIA 1WYGA 2P13A 3I99A 2VFSA 4BCAA 3NVYB 4ML8A 1W1QA 5D79A 2PLIA 1RM6B 2Q4WA 3S1DA 2EXRA 2UUVA 2VFVA 1HSKA
chains in the Genus database with same CATH topology

5L6GA 2VAOA 5HMRA 3NVVB 3HRDC 1W1RA 1FFUC 2VFRA 3PM9A 3FW7A 5FXFA 5FXEA 2P4PA 1W1JA 5G5GB 3D2JA 1I19A 4PVKA 3LAEA 1JROA 3SR6B 1VDVA 3AMZA 2Y4GA 1F0XA 1W1KA 4ZOHB 4PWCA 1E0YA 3DQ0A 2P3HA 1E8HA 1WVFA 1FIQB 3VTEA 1W1SA 5I1VA 2WDWA 2OAIA 2VFUA 4OALA 2BVFA 2R8DA 3S1EA 3TX1A 5AE1A 4BC9A 3NRZB 3RJAA 2RK5A 3BW7A 3S1CA 1N5XA 1W1LA 1DIQA 3TSHA 3EUB3 5G5HB 1MBTA 3AN1A 1AHUA 2W55A 3B9JB 4PYTA 4EC3A 2O3GA 2UUUA 1ZR6A 3NVWB 2QKNA 3D2DA 3FW8A 3TSJA 2YVSA 1N63C 2Y08A 1DIIA 1N61C 3FW9A 5AWVA 2VFTA 2GQUA 5L6FA 3AM9A 2AXRA 4PVEA 2Y3RA 1N62C 2E3TA 4PWBA 2W54A 5HHZA 1SB3B 1WVEA 4JB1A 1E8FA 4UD8A 2BVGA 1AHZA 2MBRA 4BBYA 2W3SA 1QLUA 3W8XA 5AE3A 3POPA 1AHVA 4JAYA 1FO4A 5HQXA 1W1OA 3FWAA 2NQWA 5ADZA 1UXYA 1V97A 3PQBA 4O95A 3GSYA 2BVHA 1MBBA 1T3QC 4DNSA 1E8GA 2PLSA 3LLBA 4HG0A 4PZFA 4PVJA 3D2HA 1VAOA 3JS8A 3HSUA 1JRPA 2R2ZA 3C0PA 5I1WA 4BC7A 2QPMA 2Y3SA 3NVZB 3S1FA 4PVHA 3W8WA 3NS1B 4XLOA 3RJ8A 5K8EA 1W1MA 3W8ZA 1DZNA 2I0KA 2W3RA 1N60C 1N5WC 5FXDA 3KJMA 3ETRB 1ZXIC 4MLAA 5FXPA 2Q85A 1QLTA 1FFVC 2GQTA 3DEDA 5AE2A 2IPIA 1WYGA 2P13A 3I99A 2VFSA 4BCAA 3NVYB 4ML8A 1W1QA 5D79A 2PLIA 1RM6B 2Q4WA 3S1DA 2EXRA 2UUVA 2VFVA 1HSKA
chains in the Genus database with same CATH homology

#chains in the Genus database with same CATH superfamily
 2VAO A;  5HMR A;  3NVV B;  3HRD C;  1W1R A;  1FFU C;  2VFR A;  3PM9 A;  3FW7 A;  5FXF A;  5FXE A;  2P4P A;  1W1J A;  5G5G B;  3D2J A;  1I19 A;  4PVK A;  3LAE A;  1JRO A;  3SR6 B;  1VDV A;  3AMZ A;  1F0X A;  1W1K A;  4ZOH B;  4PWC A;  1E0Y A;  3DQ0 A;  2P3H A;  1E8H A;  1WVF A;  1FIQ B;  3VTE A;  1W1S A;  2OAI A;  2VFU A;  4OAL A;  2BVF A;  2R8D A;  3S1E A;  3TX1 A;  5AE1 A;  4BC9 A;  3NRZ B;  2RK5 A;  3BW7 A;  3S1C A;  1N5X A;  1W1L A;  1DIQ A;  3TSH A;  3EUB 3;  5G5H B;  1MBT A;  3AN1 A;  1AHU A;  2W55 A;  3B9J B;  4PYT A;  4EC3 A;  2O3G A;  1ZR6 A;  3NVW B;  2QKN A;  3D2D A;  3FW8 A;  3TSJ A;  2YVS A;  1N63 C;  1DII A;  1N61 C;  3FW9 A;  2VFT A;  2GQU A;  3AM9 A;  2AXR A;  4PVE A;  1N62 C;  2E3T A;  4PWB A;  2W54 A;  5HHZ A;  1SB3 B;  1WVE A;  4JB1 A;  1E8F A;  4UD8 A;  2BVG A;  1AHZ A;  2MBR A;  4BBY A;  2W3S A;  1QLU A;  3W8X A;  5AE3 A;  1AHV A;  4JAY A;  1FO4 A;  5HQX A;  1W1O A;  3FWA A;  2NQW A;  5ADZ A;  1UXY A;  1V97 A;  4O95 A;  3GSY A;  2BVH A;  1MBB A;  1T3Q C;  4DNS A;  1E8G A;  2PLS A;  3LLB A;  4HG0 A;  4PZF A;  4PVJ A;  3D2H A;  1VAO A;  3JS8 A;  1JRP A;  2R2Z A;  3C0P A;  4BC7 A;  2QPM A;  3NVZ B;  3S1F A;  4PVH A;  3W8W A;  3NS1 B;  4XLO A;  1W1M A;  3W8Z A;  1DZN A;  2I0K A;  2W3R A;  1N60 C;  1N5W C;  5FXD A;  3KJM A;  3ETR B;  1ZXI C;  4MLA A;  5FXP A;  2Q85 A;  1QLT A;  1FFV C;  2GQT A;  3DED A;  5AE2 A;  1WYG A;  2P13 A;  3I99 A;  2VFS A;  4BCA A;  3NVY B;  4ML8 A;  1W1Q A;  5D79 A;  2PLI A;  1RM6 B;  2Q4W A;  3S1D A;  2EXR A;  2VFV A;  1HSK A; 
#chains in the Genus database with same CATH topology
 5L6G A;  2VAO A;  5HMR A;  3NVV B;  3HRD C;  1W1R A;  1FFU C;  2VFR A;  3PM9 A;  3FW7 A;  5FXF A;  5FXE A;  2P4P A;  1W1J A;  5G5G B;  3D2J A;  1I19 A;  4PVK A;  3LAE A;  1JRO A;  3SR6 B;  1VDV A;  3AMZ A;  2Y4G A;  1F0X A;  1W1K A;  4ZOH B;  4PWC A;  1E0Y A;  3DQ0 A;  2P3H A;  1E8H A;  1WVF A;  1FIQ B;  3VTE A;  1W1S A;  5I1V A;  2WDW A;  2OAI A;  2VFU A;  4OAL A;  2BVF A;  2R8D A;  3S1E A;  3TX1 A;  5AE1 A;  4BC9 A;  3NRZ B;  3RJA A;  2RK5 A;  3BW7 A;  3S1C A;  1N5X A;  1W1L A;  1DIQ A;  3TSH A;  3EUB 3;  5G5H B;  1MBT A;  3AN1 A;  1AHU A;  2W55 A;  3B9J B;  4PYT A;  4EC3 A;  2O3G A;  2UUU A;  1ZR6 A;  3NVW B;  2QKN A;  3D2D A;  3FW8 A;  3EJD B;  3TSJ A;  2YVS A;  1N63 C;  2Y08 A;  1DII A;  1N61 C;  3FW9 A;  5AWV A;  2VFT A;  2GQU A;  3EJE B;  5L6F A;  3AM9 A;  2AXR A;  4PVE A;  2Y3R A;  1N62 C;  2E3T A;  4PWB A;  2W54 A;  5HHZ A;  1SB3 B;  1WVE A;  4JB1 A;  1E8F A;  4UD8 A;  2BVG A;  1AHZ A;  2MBR A;  4BBY A;  2W3S A;  1QLU A;  3W8X A;  5AE3 A;  3POP A;  1AHV A;  4JAY A;  1FO4 A;  5HQX A;  1W1O A;  3FWA A;  2NQW A;  5ADZ A;  1UXY A;  1V97 A;  3PQB A;  4O95 A;  3GSY A;  2BVH A;  1MBB A;  1T3Q C;  4DNS A;  1E8G A;  2PLS A;  3LLB A;  4HG0 A;  4PZF A;  4PVJ A;  3D2H A;  1VAO A;  3JS8 A;  3HSU A;  1JRP A;  3EJB B;  2R2Z A;  3C0P A;  5I1W A;  4BC7 A;  2QPM A;  2Y3S A;  3NVZ B;  3S1F A;  4PVH A;  3W8W A;  3NS1 B;  4XLO A;  3RJ8 A;  5K8E A;  1W1M A;  3W8Z A;  1DZN A;  2I0K A;  2W3R A;  1N60 C;  1N5W C;  5FXD A;  3KJM A;  3ETR B;  1ZXI C;  4MLA A;  5FXP A;  2Q85 A;  1QLT A;  1FFV C;  2GQT A;  3DED A;  5AE2 A;  2IPI A;  1WYG A;  2P13 A;  3I99 A;  2VFS A;  4BCA A;  3NVY B;  4ML8 A;  1W1Q A;  5D79 A;  2PLI A;  1RM6 B;  2Q4W A;  3S1D A;  2EXR A;  2UUV A;  2VFV A;  1HSK A; 
#chains in the Genus database with same CATH homology
 5L6G A;  2VAO A;  5HMR A;  3NVV B;  3HRD C;  1W1R A;  1FFU C;  2VFR A;  3PM9 A;  3FW7 A;  5FXF A;  5FXE A;  2P4P A;  1W1J A;  5G5G B;  3D2J A;  1I19 A;  4PVK A;  3LAE A;  1JRO A;  3SR6 B;  1VDV A;  3AMZ A;  2Y4G A;  1F0X A;  1W1K A;  4ZOH B;  4PWC A;  1E0Y A;  3DQ0 A;  2P3H A;  1E8H A;  1WVF A;  1FIQ B;  3VTE A;  1W1S A;  5I1V A;  2WDW A;  2OAI A;  2VFU A;  4OAL A;  2BVF A;  2R8D A;  3S1E A;  3TX1 A;  5AE1 A;  4BC9 A;  3NRZ B;  3RJA A;  2RK5 A;  3BW7 A;  3S1C A;  1N5X A;  1W1L A;  1DIQ A;  3TSH A;  3EUB 3;  5G5H B;  1MBT A;  3AN1 A;  1AHU A;  2W55 A;  3B9J B;  4PYT A;  4EC3 A;  2O3G A;  2UUU A;  1ZR6 A;  3NVW B;  2QKN A;  3D2D A;  3FW8 A;  3TSJ A;  2YVS A;  1N63 C;  2Y08 A;  1DII A;  1N61 C;  3FW9 A;  5AWV A;  2VFT A;  2GQU A;  5L6F A;  3AM9 A;  2AXR A;  4PVE A;  2Y3R A;  1N62 C;  2E3T A;  4PWB A;  2W54 A;  5HHZ A;  1SB3 B;  1WVE A;  4JB1 A;  1E8F A;  4UD8 A;  2BVG A;  1AHZ A;  2MBR A;  4BBY A;  2W3S A;  1QLU A;  3W8X A;  5AE3 A;  3POP A;  1AHV A;  4JAY A;  1FO4 A;  5HQX A;  1W1O A;  3FWA A;  2NQW A;  5ADZ A;  1UXY A;  1V97 A;  3PQB A;  4O95 A;  3GSY A;  2BVH A;  1MBB A;  1T3Q C;  4DNS A;  1E8G A;  2PLS A;  3LLB A;  4HG0 A;  4PZF A;  4PVJ A;  3D2H A;  1VAO A;  3JS8 A;  3HSU A;  1JRP A;  2R2Z A;  3C0P A;  5I1W A;  4BC7 A;  2QPM A;  2Y3S A;  3NVZ B;  3S1F A;  4PVH A;  3W8W A;  3NS1 B;  4XLO A;  3RJ8 A;  5K8E A;  1W1M A;  3W8Z A;  1DZN A;  2I0K A;  2W3R A;  1N60 C;  1N5W C;  5FXD A;  3KJM A;  3ETR B;  1ZXI C;  4MLA A;  5FXP A;  2Q85 A;  1QLT A;  1FFV C;  2GQT A;  3DED A;  5AE2 A;  2IPI A;  1WYG A;  2P13 A;  3I99 A;  2VFS A;  4BCA A;  3NVY B;  4ML8 A;  1W1Q A;  5D79 A;  2PLI A;  1RM6 B;  2Q4W A;  3S1D A;  2EXR A;  2UUV A;  2VFV A;  1HSK A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

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#similar chains, but unknotted
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1I19A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations