1W1LA

Structure of the octameric flavoenzyme vanillyl-alcohol oxidase: phe454tyr mutant
Total Genus 170
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
170
sequence length
555
structure length
550
Chain Sequence
EFRPLTLPPKLSLSDFNEFIQDIIRIVGSENVEVISVDGSYMKPTHTHDPHHVMDQDYFLASAIVAPRNVADVQSIVGLANKFSFPLWPISIGRNSGYGGAAPRVSGSVVLDMGKNMNRVLEVNVEGAYCVVEPGVTYHDLHNYLEANNLRDKLWLDVPDLGGGSVLGNAVERGVGYTPYGDHWMMHSGMEVVLANGELLRTGMGALPDPKRPETMGLKPEDQPWSKIAHLFPYGFGPYIDGLFSQSNMGIVTKIGIWLMPNPRGYQSYLITLPKDGDLKQAVDIIRPLRLGMALQNVPTIRHILLDAAVLGDKRSYSSRTEPLSDEELDKIAKQLNLGRWNFYGALYGPEPIRRVLWETIKDAFSAIPGVKFYFPEDTPENSVLRVRDKTMQGIPTYDELKWIDWLPNGAHLFFSPIAKVSGEDAMMQYAVTKKRCQEAGLDYIGTFTVGMREMHHIVCIVFNKKDLIQKRKVQWLMRTLIDDCAANGWGEYRTHLAFMDQIMETYNWNNSSFLRFNEVLKNAVDPNGIIAPGKSGVWPSQYSHVTWKL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Laboratory-Evolved Vanillyl-Alcohol Oxidase Produces Natural Vanillin
pubmed doi rcsb
source organism Penicillium simplicissimum
molecule tags Oxidoreductase
molecule keywords VANILLYL-ALCOHOL OXIDASE
total genus 170
structure length 550
sequence length 555
chains with identical sequence B
ec nomenclature ec 1.1.3.38: Vanillyl-alcohol oxidase.
pdb deposition date 2004-06-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01565 FAD_binding_4 FAD binding domain
A PF02913 FAD-oxidase_C FAD linked oxidases, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.45.10 Mainly Alpha Orthogonal Bundle Vanillyl-alcohol Oxidase; Chain A, domain 4 Vanillyl-alcohol Oxidase; Chain A, domain 4 1w1lA04
3.30.43.10 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2 1w1lA01
3.30.465.10 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 1w1lA02
3.40.462.10 Alpha Beta 3-Layer(aba) Sandwich Vanillyl-alcohol Oxidase; Chain A, domain 3 FAD-linked oxidases, C-terminal domain 1w1lA03
5AE2A 3TSHA 3DEDA 4PWBA 3LLBA 3BW7A 3NVVB 2Q4WA 4BCAA 3VTEA 5HHZA 5HMRA 3D2HA 3W8WA 4BBYA 4PVEA 3FW8A 1VDVA 3KJMA 4PVJA 2BVFA 3FW9A 1I19A 2OAIA 3AN1A 4ML8A 2PLSA 2I0KA 1E8GA 4PZFA 1WYGA 3I99A 3TSJA 1RM6B 4BC9A 2P4PA 1W1MA 2VFVA 3D2DA 5FXDA 1W1JA 4DNSA 1JRPA 2AXRA 3NVZB 3JS8A 1HSKA 2QPMA 1N5WC 3HRDC 1T3QC 4HG0A 1ZR6A 4PVHA 5FXFA 1W1OA 5ADZA 5FXEA 1JROA 4JB1A 1E8HA 1V97A 4PWCA 2EXRA 1UXYA 1FO4A 1MBBA 1W1SA 3LAEA 4UD8A 3D2JA 4XLOA 3NVWB 2O3GA 1VAOA 1WVEA 1W1RA 3AM9A 4OALA 1DIQA 3EUB3 2R2ZA 3NVYB 2E3TA 2VFSA 2VFRA 5D79A 5G5GB 1W1LA 4MLAA 3S1DA 2VFTA 1DZNA 2P3HA 2YVSA 1FFVC 5G5HB 2VFUA 1QLTA 5FXPA 2GQTA 2QKNA 1AHUA 3TX1A 2RK5A 3S1CA 2Q85A 1DIIA 2GQUA 2W3RA 1AHVA 2MBRA 3FW7A 1N60C 1QLUA 3W8ZA 3S1FA 2NQWA 3W8XA 1N61C 1W1QA 2BVGA 3NRZB 4ZOHB 1FIQB 3SR6B 2W55A 2W54A 1N5XA 1AHZA 1WVFA 4JAYA 5AE3A 3ETRB 2P13A 1N62C 3S1EA 4EC3A 3C0PA 3B9JB 4PYTA 1E0YA 1N63C 3GSYA 5HQXA 1E8FA 5AE1A 3FWAA 1SB3B 2R8DA 3NS1B 2PLIA 1FFUC 3DQ0A 1MBTA 1F0XA 4PVKA 3PM9A 1W1KA 2VAOA 3AMZA 1ZXIC 2W3SA 4O95A 4BC7A 2BVHA
chains in the Genus database with same CATH superfamily
5AE2A 3TSHA 3DEDA 4PWBA 3LLBA 2Y3RA 3BW7A 3NVVB 2Q4WA 4BCAA 3VTEA 5HHZA 5HMRA 3D2HA 3W8WA 5I1WA 4BBYA 4PVEA 3FW8A 1VDVA 3KJMA 4PVJA 2BVFA 3FW9A 1I19A 2OAIA 3AN1A 4ML8A 2PLSA 2I0KA 1E8GA 3EJBB 4PZFA 5L6FA 1WYGA 3I99A 3TSJA 1RM6B 4BC9A 3HSUA 2P4PA 1W1MA 2VFVA 2IPIA 3D2DA 5FXDA 1W1JA 4DNSA 1JRPA 5K8EA 2UUVA 2AXRA 3NVZB 3POPA 3JS8A 2Y08A 1HSKA 2QPMA 1N5WC 3HRDC 1T3QC 4HG0A 5L6GA 2Y3SA 1ZR6A 4PVHA 5FXFA 5AWVA 1W1OA 5ADZA 5FXEA 1JROA 4JB1A 5I1VA 1E8HA 1V97A 4PWCA 2EXRA 1UXYA 1FO4A 1MBBA 1W1SA 3LAEA 4UD8A 3D2JA 4XLOA 3NVWB 2O3GA 1VAOA 1WVEA 1W1RA 3AM9A 4OALA 1DIQA 3EUB3 2R2ZA 3NVYB 2E3TA 2VFSA 2VFRA 5D79A 5G5GB 1W1LA 4MLAA 3S1DA 2VFTA 1DZNA 2P3HA 3EJEB 2YVSA 1FFVC 5G5HB 2VFUA 1QLTA 5FXPA 2GQTA 3RJ8A 2QKNA 1AHUA 3TX1A 2RK5A 3S1CA 2Q85A 1DIIA 2GQUA 2W3RA 1AHVA 3PQBA 2MBRA 3FW7A 1N60C 1QLUA 3W8ZA 3S1FA 2NQWA 3W8XA 1N61C 1W1QA 2BVGA 3NRZB 4ZOHB 1FIQB 3SR6B 2W55A 2W54A 1N5XA 2UUUA 1AHZA 1WVFA 4JAYA 3RJAA 5AE3A 3ETRB 2P13A 1N62C 3S1EA 4EC3A 3C0PA 3B9JB 4PYTA 1E0YA 3EJDB 1N63C 3GSYA 5HQXA 1E8FA 5AE1A 3FWAA 2Y4GA 1SB3B 2R8DA 3NS1B 2PLIA 1FFUC 3DQ0A 1MBTA 1F0XA 4PVKA 2WDWA 3PM9A 1W1KA 2VAOA 3AMZA 1ZXIC 2W3SA 4O95A 4BC7A 2BVHA
chains in the Genus database with same CATH topology
5AE2A 3TSHA 3DEDA 4PWBA 3LLBA 2Y3RA 3BW7A 3NVVB 2Q4WA 4BCAA 3VTEA 5HHZA 5HMRA 3D2HA 3W8WA 5I1WA 4BBYA 4PVEA 3FW8A 1VDVA 3KJMA 4PVJA 2BVFA 3FW9A 1I19A 2OAIA 3AN1A 4ML8A 2PLSA 2I0KA 1E8GA 4PZFA 5L6FA 1WYGA 3I99A 3TSJA 1RM6B 4BC9A 3HSUA 2P4PA 1W1MA 2VFVA 2IPIA 3D2DA 5FXDA 1W1JA 4DNSA 1JRPA 5K8EA 2UUVA 2AXRA 3NVZB 3POPA 3JS8A 2Y08A 1HSKA 2QPMA 1N5WC 3HRDC 1T3QC 4HG0A 5L6GA 2Y3SA 1ZR6A 4PVHA 5FXFA 5AWVA 1W1OA 5ADZA 5FXEA 1JROA 4JB1A 5I1VA 1E8HA 1V97A 4PWCA 2EXRA 1UXYA 1FO4A 1MBBA 1W1SA 3LAEA 4UD8A 3D2JA 4XLOA 3NVWB 2O3GA 1VAOA 1WVEA 1W1RA 3AM9A 4OALA 1DIQA 3EUB3 2R2ZA 3NVYB 2E3TA 2VFSA 2VFRA 5D79A 5G5GB 1W1LA 4MLAA 3S1DA 2VFTA 1DZNA 2P3HA 2YVSA 1FFVC 5G5HB 2VFUA 1QLTA 5FXPA 2GQTA 3RJ8A 2QKNA 1AHUA 3TX1A 2RK5A 3S1CA 2Q85A 1DIIA 2GQUA 2W3RA 1AHVA 3PQBA 2MBRA 3FW7A 1N60C 1QLUA 3W8ZA 3S1FA 2NQWA 3W8XA 1N61C 1W1QA 2BVGA 3NRZB 4ZOHB 1FIQB 3SR6B 2W55A 2W54A 1N5XA 2UUUA 1AHZA 1WVFA 4JAYA 3RJAA 5AE3A 3ETRB 2P13A 1N62C 3S1EA 4EC3A 3C0PA 3B9JB 4PYTA 1E0YA 1N63C 3GSYA 5HQXA 1E8FA 5AE1A 3FWAA 2Y4GA 1SB3B 2R8DA 3NS1B 2PLIA 1FFUC 3DQ0A 1MBTA 1F0XA 4PVKA 2WDWA 3PM9A 1W1KA 2VAOA 3AMZA 1ZXIC 2W3SA 4O95A 4BC7A 2BVHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5AE2 A;  3TSH A;  3DED A;  4PWB A;  3LLB A;  3BW7 A;  3NVV B;  2Q4W A;  4BCA A;  3VTE A;  5HHZ A;  5HMR A;  3D2H A;  3W8W A;  4BBY A;  4PVE A;  3FW8 A;  1VDV A;  3KJM A;  4PVJ A;  2BVF A;  3FW9 A;  1I19 A;  2OAI A;  3AN1 A;  4ML8 A;  2PLS A;  2I0K A;  1E8G A;  4PZF A;  1WYG A;  3I99 A;  3TSJ A;  1RM6 B;  4BC9 A;  2P4P A;  1W1M A;  2VFV A;  3D2D A;  5FXD A;  1W1J A;  4DNS A;  1JRP A;  2AXR A;  3NVZ B;  3JS8 A;  1HSK A;  2QPM A;  1N5W C;  3HRD C;  1T3Q C;  4HG0 A;  1ZR6 A;  4PVH A;  5FXF A;  1W1O A;  5ADZ A;  5FXE A;  1JRO A;  4JB1 A;  1E8H A;  1V97 A;  4PWC A;  2EXR A;  1UXY A;  1FO4 A;  1MBB A;  1W1S A;  3LAE A;  4UD8 A;  3D2J A;  4XLO A;  3NVW B;  2O3G A;  1VAO A;  1WVE A;  1W1R A;  3AM9 A;  4OAL A;  1DIQ A;  3EUB 3;  2R2Z A;  3NVY B;  2E3T A;  2VFS A;  2VFR A;  5D79 A;  5G5G B;  1W1L A;  4MLA A;  3S1D A;  2VFT A;  1DZN A;  2P3H A;  2YVS A;  1FFV C;  5G5H B;  2VFU A;  1QLT A;  5FXP A;  2GQT A;  2QKN A;  1AHU A;  3TX1 A;  2RK5 A;  3S1C A;  2Q85 A;  1DII A;  2GQU A;  2W3R A;  1AHV A;  2MBR A;  3FW7 A;  1N60 C;  1QLU A;  3W8Z A;  3S1F A;  2NQW A;  3W8X A;  1N61 C;  1W1Q A;  2BVG A;  3NRZ B;  4ZOH B;  1FIQ B;  3SR6 B;  2W55 A;  2W54 A;  1N5X A;  1AHZ A;  1WVF A;  4JAY A;  5AE3 A;  3ETR B;  2P13 A;  1N62 C;  3S1E A;  4EC3 A;  3C0P A;  3B9J B;  4PYT A;  1E0Y A;  1N63 C;  3GSY A;  5HQX A;  1E8F A;  5AE1 A;  3FWA A;  1SB3 B;  2R8D A;  3NS1 B;  2PLI A;  1FFU C;  3DQ0 A;  1MBT A;  1F0X A;  4PVK A;  3PM9 A;  1W1K A;  2VAO A;  3AMZ A;  1ZXI C;  2W3S A;  4O95 A;  4BC7 A;  2BVH A; 
#chains in the Genus database with same CATH topology
 5AE2 A;  3TSH A;  3DED A;  4PWB A;  3LLB A;  2Y3R A;  3BW7 A;  3NVV B;  2Q4W A;  4BCA A;  3VTE A;  5HHZ A;  5HMR A;  3D2H A;  3W8W A;  5I1W A;  4BBY A;  4PVE A;  3FW8 A;  1VDV A;  3KJM A;  4PVJ A;  2BVF A;  3FW9 A;  1I19 A;  2OAI A;  3AN1 A;  4ML8 A;  2PLS A;  2I0K A;  1E8G A;  3EJB B;  4PZF A;  5L6F A;  1WYG A;  3I99 A;  3TSJ A;  1RM6 B;  4BC9 A;  3HSU A;  2P4P A;  1W1M A;  2VFV A;  2IPI A;  3D2D A;  5FXD A;  1W1J A;  4DNS A;  1JRP A;  5K8E A;  2UUV A;  2AXR A;  3NVZ B;  3POP A;  3JS8 A;  2Y08 A;  1HSK A;  2QPM A;  1N5W C;  3HRD C;  1T3Q C;  4HG0 A;  5L6G A;  2Y3S A;  1ZR6 A;  4PVH A;  5FXF A;  5AWV A;  1W1O A;  5ADZ A;  5FXE A;  1JRO A;  4JB1 A;  5I1V A;  1E8H A;  1V97 A;  4PWC A;  2EXR A;  1UXY A;  1FO4 A;  1MBB A;  1W1S A;  3LAE A;  4UD8 A;  3D2J A;  4XLO A;  3NVW B;  2O3G A;  1VAO A;  1WVE A;  1W1R A;  3AM9 A;  4OAL A;  1DIQ A;  3EUB 3;  2R2Z A;  3NVY B;  2E3T A;  2VFS A;  2VFR A;  5D79 A;  5G5G B;  1W1L A;  4MLA A;  3S1D A;  2VFT A;  1DZN A;  2P3H A;  3EJE B;  2YVS A;  1FFV C;  5G5H B;  2VFU A;  1QLT A;  5FXP A;  2GQT A;  3RJ8 A;  2QKN A;  1AHU A;  3TX1 A;  2RK5 A;  3S1C A;  2Q85 A;  1DII A;  2GQU A;  2W3R A;  1AHV A;  3PQB A;  2MBR A;  3FW7 A;  1N60 C;  1QLU A;  3W8Z A;  3S1F A;  2NQW A;  3W8X A;  1N61 C;  1W1Q A;  2BVG A;  3NRZ B;  4ZOH B;  1FIQ B;  3SR6 B;  2W55 A;  2W54 A;  1N5X A;  2UUU A;  1AHZ A;  1WVF A;  4JAY A;  3RJA A;  5AE3 A;  3ETR B;  2P13 A;  1N62 C;  3S1E A;  4EC3 A;  3C0P A;  3B9J B;  4PYT A;  1E0Y A;  3EJD B;  1N63 C;  3GSY A;  5HQX A;  1E8F A;  5AE1 A;  3FWA A;  2Y4G A;  1SB3 B;  2R8D A;  3NS1 B;  2PLI A;  1FFU C;  3DQ0 A;  1MBT A;  1F0X A;  4PVK A;  2WDW A;  3PM9 A;  1W1K A;  2VAO A;  3AMZ A;  1ZXI C;  2W3S A;  4O95 A;  4BC7 A;  2BVH A; 
#chains in the Genus database with same CATH homology
 5AE2 A;  3TSH A;  3DED A;  4PWB A;  3LLB A;  2Y3R A;  3BW7 A;  3NVV B;  2Q4W A;  4BCA A;  3VTE A;  5HHZ A;  5HMR A;  3D2H A;  3W8W A;  5I1W A;  4BBY A;  4PVE A;  3FW8 A;  1VDV A;  3KJM A;  4PVJ A;  2BVF A;  3FW9 A;  1I19 A;  2OAI A;  3AN1 A;  4ML8 A;  2PLS A;  2I0K A;  1E8G A;  4PZF A;  5L6F A;  1WYG A;  3I99 A;  3TSJ A;  1RM6 B;  4BC9 A;  3HSU A;  2P4P A;  1W1M A;  2VFV A;  2IPI A;  3D2D A;  5FXD A;  1W1J A;  4DNS A;  1JRP A;  5K8E A;  2UUV A;  2AXR A;  3NVZ B;  3POP A;  3JS8 A;  2Y08 A;  1HSK A;  2QPM A;  1N5W C;  3HRD C;  1T3Q C;  4HG0 A;  5L6G A;  2Y3S A;  1ZR6 A;  4PVH A;  5FXF A;  5AWV A;  1W1O A;  5ADZ A;  5FXE A;  1JRO A;  4JB1 A;  5I1V A;  1E8H A;  1V97 A;  4PWC A;  2EXR A;  1UXY A;  1FO4 A;  1MBB A;  1W1S A;  3LAE A;  4UD8 A;  3D2J A;  4XLO A;  3NVW B;  2O3G A;  1VAO A;  1WVE A;  1W1R A;  3AM9 A;  4OAL A;  1DIQ A;  3EUB 3;  2R2Z A;  3NVY B;  2E3T A;  2VFS A;  2VFR A;  5D79 A;  5G5G B;  1W1L A;  4MLA A;  3S1D A;  2VFT A;  1DZN A;  2P3H A;  2YVS A;  1FFV C;  5G5H B;  2VFU A;  1QLT A;  5FXP A;  2GQT A;  3RJ8 A;  2QKN A;  1AHU A;  3TX1 A;  2RK5 A;  3S1C A;  2Q85 A;  1DII A;  2GQU A;  2W3R A;  1AHV A;  3PQB A;  2MBR A;  3FW7 A;  1N60 C;  1QLU A;  3W8Z A;  3S1F A;  2NQW A;  3W8X A;  1N61 C;  1W1Q A;  2BVG A;  3NRZ B;  4ZOH B;  1FIQ B;  3SR6 B;  2W55 A;  2W54 A;  1N5X A;  2UUU A;  1AHZ A;  1WVF A;  4JAY A;  3RJA A;  5AE3 A;  3ETR B;  2P13 A;  1N62 C;  3S1E A;  4EC3 A;  3C0P A;  3B9J B;  4PYT A;  1E0Y A;  1N63 C;  3GSY A;  5HQX A;  1E8F A;  5AE1 A;  3FWA A;  2Y4G A;  1SB3 B;  2R8D A;  3NS1 B;  2PLI A;  1FFU C;  3DQ0 A;  1MBT A;  1F0X A;  4PVK A;  2WDW A;  3PM9 A;  1W1K A;  2VAO A;  3AMZ A;  1ZXI C;  2W3S A;  4O95 A;  4BC7 A;  2BVH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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