1W1LA

Structure of the octameric flavoenzyme vanillyl-alcohol oxidase: phe454tyr mutant
Total Genus 170
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
170
sequence length
555
structure length
550
Chain Sequence
EFRPLTLPPKLSLSDFNEFIQDIIRIVGSENVEVISVDGSYMKPTHTHDPHHVMDQDYFLASAIVAPRNVADVQSIVGLANKFSFPLWPISIGRNSGYGGAAPRVSGSVVLDMGKNMNRVLEVNVEGAYCVVEPGVTYHDLHNYLEANNLRDKLWLDVPDLGGGSVLGNAVERGVGYTPYGDHWMMHSGMEVVLANGELLRTGMGALPDPKRPETMGLKPEDQPWSKIAHLFPYGFGPYIDGLFSQSNMGIVTKIGIWLMPNPRGYQSYLITLPKDGDLKQAVDIIRPLRLGMALQNVPTIRHILLDAAVLGDKRSYSSRTEPLSDEELDKIAKQLNLGRWNFYGALYGPEPIRRVLWETIKDAFSAIPGVKFYFPEDTPENSVLRVRDKTMQGIPTYDELKWIDWLPNGAHLFFSPIAKVSGEDAMMQYAVTKKRCQEAGLDYIGTFTVGMREMHHIVCIVFNKKDLIQKRKVQWLMRTLIDDCAANGWGEYRTHLAFMDQIMETYNWNNSSFLRFNEVLKNAVDPNGIIAPGKSGVWPSQYSHVTWKL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Laboratory-Evolved Vanillyl-Alcohol Oxidase Produces Natural Vanillin
pubmed doi rcsb
source organism Penicillium simplicissimum
molecule tags Oxidoreductase
molecule keywords VANILLYL-ALCOHOL OXIDASE
total genus 170
structure length 550
sequence length 555
chains with identical sequence B
ec nomenclature ec 1.1.3.38: Vanillyl-alcohol oxidase.
pdb deposition date 2004-06-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01565 FAD_binding_4 FAD binding domain
A PF02913 FAD-oxidase_C FAD linked oxidases, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.45.10 Mainly Alpha Orthogonal Bundle Vanillyl-alcohol Oxidase; Chain A, domain 4 Vanillyl-alcohol Oxidase; Chain A, domain 4 1w1lA04
3.30.43.10 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2 1w1lA01
3.30.465.10 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 1w1lA02
3.40.462.10 Alpha Beta 3-Layer(aba) Sandwich Vanillyl-alcohol Oxidase; Chain A, domain 3 FAD-linked oxidases, C-terminal domain 1w1lA03
2BVGA 2VFSA 2OAIA 4PVKA 1T3QC 4HG0A 3FW7A 4JB1A 3W8ZA 3D2HA 5FXPA 1W1OA 3S1EA 1W1JA 1JROA 2Q85A 1WVEA 5AE2A 3NVVB 3BW7A 1WYGA 4JAYA 1JRPA 3SR6B 5HHZA 5FXDA 3VTEA 1V97A 3JS8A 1E8HA 2EXRA 4DNSA 1UXYA 1ZR6A 3LAEA 1FIQB 2QPMA 1AHZA 1SB3B 5G5GB 1I19A 2VFVA 3S1FA 2AXRA 1DZNA 4ML8A 1VDVA 3NRZB 5ADZA 1N63C 3C0PA 4PWBA 1AHVA 1W1RA 3AMZA 3GSYA 2W3SA 3DQ0A 4BBYA 2Q4WA 3EUB3 3S1CA 3AM9A 4ZOHB 1WVFA 4BCAA 3NS1B 3LLBA 1N61C 2P13A 1VAOA 3DEDA 4PYTA 2PLIA 2I0KA 4OALA 1E8FA 1FO4A 2O3GA 2E3TA 2W3RA 1N5WC 5AE1A 3B9JB 1W1LA 4PVJA 3TX1A 1E8GA 2NQWA 3NVYB 2MBRA 3D2JA 1DIQA 5FXFA 3AN1A 1E0YA 1FFVC 5HMRA 1HSKA 1ZXIC 2P4PA 4PVEA 1N62C 2VAOA 3ETRB 1N60C 1W1MA 3HRDC 5G5HB 3FW8A 3TSHA 2R2ZA 3W8XA 1W1KA 4MLAA 2QKNA 1RM6B 1FFUC 3FW9A 3NVWB 2GQUA 3PM9A 3TSJA 4XLOA 2YVSA 5FXEA 3S1DA 1DIIA 2VFRA 2P3HA 3FWAA 4PVHA 3W8WA 5D79A 4EC3A 2W54A 2BVHA 5HQXA 2RK5A 1W1SA 3NVZB 1N5XA 3I99A 2PLSA 1QLUA 3KJMA 4O95A 1F0XA 2W55A 4PZFA 3D2DA 2R8DA 1QLTA 2BVFA 1MBTA 2VFTA 4BC7A 4PWCA 4UD8A 1AHUA 1MBBA 2GQTA 1W1QA 5AE3A 2VFUA 4BC9A
chains in the Genus database with same CATH superfamily
2BVGA 3EJDB 2VFSA 2OAIA 4PVKA 1T3QC 4HG0A 3FW7A 4JB1A 3W8ZA 3D2HA 5FXPA 1W1OA 3S1EA 5I1WA 2Y08A 1W1JA 1JROA 2Q85A 1WVEA 5AE2A 3NVVB 3HSUA 3BW7A 1WYGA 3PQBA 4JAYA 1JRPA 3RJ8A 3SR6B 5HHZA 5FXDA 3VTEA 1V97A 3JS8A 1E8HA 2EXRA 5L6GA 2WDWA 4DNSA 1UXYA 1ZR6A 2Y3SA 3LAEA 1FIQB 2QPMA 1AHZA 3RJAA 1SB3B 5G5GB 1I19A 2VFVA 3S1FA 3POPA 2AXRA 1DZNA 4ML8A 1VDVA 3NRZB 5ADZA 1N63C 3C0PA 3EJEB 4PWBA 1AHVA 1W1RA 2Y3RA 3AMZA 3GSYA 2W3SA 3DQ0A 4BBYA 2Q4WA 3EUB3 3S1CA 3AM9A 4ZOHB 1WVFA 4BCAA 3NS1B 3LLBA 1N61C 2P13A 1VAOA 3DEDA 5L6FA 4PYTA 2PLIA 2I0KA 4OALA 1E8FA 3EJBB 1FO4A 2O3GA 2E3TA 2W3RA 1N5WC 5AE1A 3B9JB 1W1LA 3NVYB 4PVJA 1E8GA 3TX1A 2NQWA 2MBRA 3D2JA 1DIQA 5FXFA 3AN1A 1E0YA 1FFVC 5HMRA 1HSKA 1ZXIC 2P4PA 4PVEA 1N62C 2VAOA 3ETRB 1N60C 1W1MA 3HRDC 5G5HB 3FW8A 3TSHA 2R2ZA 3W8XA 1W1KA 4MLAA 2QKNA 1RM6B 1FFUC 3FW9A 3NVWB 2GQUA 2UUUA 3PM9A 3TSJA 4XLOA 2YVSA 5FXEA 3S1DA 1DIIA 2VFRA 2P3HA 3FWAA 4PVHA 3W8WA 5D79A 4EC3A 2W54A 2BVHA 5HQXA 2RK5A 1W1SA 3NVZB 1N5XA 3I99A 2PLSA 1QLUA 2IPIA 3KJMA 5K8EA 2Y4GA 4O95A 1F0XA 2W55A 4PZFA 3D2DA 2UUVA 5AWVA 2R8DA 1QLTA 2BVFA 1MBTA 2VFTA 4BC7A 4PWCA 4UD8A 1AHUA 5I1VA 1MBBA 2GQTA 1W1QA 5AE3A 2VFUA 4BC9A
chains in the Genus database with same CATH topology
2BVGA 2VFSA 2OAIA 4PVKA 1T3QC 4HG0A 3FW7A 4JB1A 3W8ZA 3D2HA 5FXPA 1W1OA 3S1EA 5I1WA 2Y08A 1W1JA 1JROA 2Q85A 1WVEA 5AE2A 3NVVB 3HSUA 3BW7A 1WYGA 3PQBA 4JAYA 1JRPA 3RJ8A 3SR6B 5HHZA 5FXDA 3VTEA 1V97A 3JS8A 1E8HA 2EXRA 5L6GA 2WDWA 4DNSA 1UXYA 1ZR6A 2Y3SA 3LAEA 1FIQB 2QPMA 1AHZA 3RJAA 1SB3B 5G5GB 1I19A 2VFVA 3S1FA 3POPA 2AXRA 1DZNA 4ML8A 1VDVA 3NRZB 5ADZA 1N63C 3C0PA 4PWBA 1AHVA 1W1RA 2Y3RA 3AMZA 3GSYA 2W3SA 3DQ0A 4BBYA 2Q4WA 3EUB3 3S1CA 3AM9A 4ZOHB 1WVFA 4BCAA 3NS1B 3LLBA 1N61C 2P13A 1VAOA 3DEDA 5L6FA 4PYTA 2PLIA 2I0KA 4OALA 1E8FA 1FO4A 2O3GA 2E3TA 2W3RA 1N5WC 5AE1A 3B9JB 1W1LA 4PVJA 3TX1A 1E8GA 2NQWA 3NVYB 2MBRA 3D2JA 1DIQA 5FXFA 3AN1A 1E0YA 1FFVC 5HMRA 1HSKA 1ZXIC 2P4PA 4PVEA 1N62C 2VAOA 3ETRB 1N60C 1W1MA 3HRDC 5G5HB 3FW8A 3TSHA 2R2ZA 3W8XA 1W1KA 4MLAA 2QKNA 1RM6B 1FFUC 3FW9A 3NVWB 2GQUA 2UUUA 3PM9A 3TSJA 4XLOA 2YVSA 5FXEA 3S1DA 1DIIA 2VFRA 2P3HA 3FWAA 4PVHA 3W8WA 5D79A 4EC3A 2W54A 2BVHA 5HQXA 2RK5A 1W1SA 3NVZB 1N5XA 3I99A 2PLSA 1QLUA 2IPIA 3KJMA 5K8EA 2Y4GA 4O95A 1F0XA 2W55A 4PZFA 3D2DA 2UUVA 5AWVA 2R8DA 1QLTA 2BVFA 1MBTA 2VFTA 4BC7A 4PWCA 4UD8A 1AHUA 5I1VA 1MBBA 2GQTA 1W1QA 5AE3A 2VFUA 4BC9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BVG A;  2VFS A;  2OAI A;  4PVK A;  1T3Q C;  4HG0 A;  3FW7 A;  4JB1 A;  3W8Z A;  3D2H A;  5FXP A;  1W1O A;  3S1E A;  1W1J A;  1JRO A;  2Q85 A;  1WVE A;  5AE2 A;  3NVV B;  3BW7 A;  1WYG A;  4JAY A;  1JRP A;  3SR6 B;  5HHZ A;  5FXD A;  3VTE A;  1V97 A;  3JS8 A;  1E8H A;  2EXR A;  4DNS A;  1UXY A;  1ZR6 A;  3LAE A;  1FIQ B;  2QPM A;  1AHZ A;  1SB3 B;  5G5G B;  1I19 A;  2VFV A;  3S1F A;  2AXR A;  1DZN A;  4ML8 A;  1VDV A;  3NRZ B;  5ADZ A;  1N63 C;  3C0P A;  4PWB A;  1AHV A;  1W1R A;  3AMZ A;  3GSY A;  2W3S A;  3DQ0 A;  4BBY A;  2Q4W A;  3EUB 3;  3S1C A;  3AM9 A;  4ZOH B;  1WVF A;  4BCA A;  3NS1 B;  3LLB A;  1N61 C;  2P13 A;  1VAO A;  3DED A;  4PYT A;  2PLI A;  2I0K A;  4OAL A;  1E8F A;  1FO4 A;  2O3G A;  2E3T A;  2W3R A;  1N5W C;  5AE1 A;  3B9J B;  1W1L A;  4PVJ A;  3TX1 A;  1E8G A;  2NQW A;  3NVY B;  2MBR A;  3D2J A;  1DIQ A;  5FXF A;  3AN1 A;  1E0Y A;  1FFV C;  5HMR A;  1HSK A;  1ZXI C;  2P4P A;  4PVE A;  1N62 C;  2VAO A;  3ETR B;  1N60 C;  1W1M A;  3HRD C;  5G5H B;  3FW8 A;  3TSH A;  2R2Z A;  3W8X A;  1W1K A;  4MLA A;  2QKN A;  1RM6 B;  1FFU C;  3FW9 A;  3NVW B;  2GQU A;  3PM9 A;  3TSJ A;  4XLO A;  2YVS A;  5FXE A;  3S1D A;  1DII A;  2VFR A;  2P3H A;  3FWA A;  4PVH A;  3W8W A;  5D79 A;  4EC3 A;  2W54 A;  2BVH A;  5HQX A;  2RK5 A;  1W1S A;  3NVZ B;  1N5X A;  3I99 A;  2PLS A;  1QLU A;  3KJM A;  4O95 A;  1F0X A;  2W55 A;  4PZF A;  3D2D A;  2R8D A;  1QLT A;  2BVF A;  1MBT A;  2VFT A;  4BC7 A;  4PWC A;  4UD8 A;  1AHU A;  1MBB A;  2GQT A;  1W1Q A;  5AE3 A;  2VFU A;  4BC9 A; 
#chains in the Genus database with same CATH topology
 2BVG A;  3EJD B;  2VFS A;  2OAI A;  4PVK A;  1T3Q C;  4HG0 A;  3FW7 A;  4JB1 A;  3W8Z A;  3D2H A;  5FXP A;  1W1O A;  3S1E A;  5I1W A;  2Y08 A;  1W1J A;  1JRO A;  2Q85 A;  1WVE A;  5AE2 A;  3NVV B;  3HSU A;  3BW7 A;  1WYG A;  3PQB A;  4JAY A;  1JRP A;  3RJ8 A;  3SR6 B;  5HHZ A;  5FXD A;  3VTE A;  1V97 A;  3JS8 A;  1E8H A;  2EXR A;  5L6G A;  2WDW A;  4DNS A;  1UXY A;  1ZR6 A;  2Y3S A;  3LAE A;  1FIQ B;  2QPM A;  1AHZ A;  3RJA A;  1SB3 B;  5G5G B;  1I19 A;  2VFV A;  3S1F A;  3POP A;  2AXR A;  1DZN A;  4ML8 A;  1VDV A;  3NRZ B;  5ADZ A;  1N63 C;  3C0P A;  3EJE B;  4PWB A;  1AHV A;  1W1R A;  2Y3R A;  3AMZ A;  3GSY A;  2W3S A;  3DQ0 A;  4BBY A;  2Q4W A;  3EUB 3;  3S1C A;  3AM9 A;  4ZOH B;  1WVF A;  4BCA A;  3NS1 B;  3LLB A;  1N61 C;  2P13 A;  1VAO A;  3DED A;  5L6F A;  4PYT A;  2PLI A;  2I0K A;  4OAL A;  1E8F A;  3EJB B;  1FO4 A;  2O3G A;  2E3T A;  2W3R A;  1N5W C;  5AE1 A;  3B9J B;  1W1L A;  3NVY B;  4PVJ A;  1E8G A;  3TX1 A;  2NQW A;  2MBR A;  3D2J A;  1DIQ A;  5FXF A;  3AN1 A;  1E0Y A;  1FFV C;  5HMR A;  1HSK A;  1ZXI C;  2P4P A;  4PVE A;  1N62 C;  2VAO A;  3ETR B;  1N60 C;  1W1M A;  3HRD C;  5G5H B;  3FW8 A;  3TSH A;  2R2Z A;  3W8X A;  1W1K A;  4MLA A;  2QKN A;  1RM6 B;  1FFU C;  3FW9 A;  3NVW B;  2GQU A;  2UUU A;  3PM9 A;  3TSJ A;  4XLO A;  2YVS A;  5FXE A;  3S1D A;  1DII A;  2VFR A;  2P3H A;  3FWA A;  4PVH A;  3W8W A;  5D79 A;  4EC3 A;  2W54 A;  2BVH A;  5HQX A;  2RK5 A;  1W1S A;  3NVZ B;  1N5X A;  3I99 A;  2PLS A;  1QLU A;  2IPI A;  3KJM A;  5K8E A;  2Y4G A;  4O95 A;  1F0X A;  2W55 A;  4PZF A;  3D2D A;  2UUV A;  5AWV A;  2R8D A;  1QLT A;  2BVF A;  1MBT A;  2VFT A;  4BC7 A;  4PWC A;  4UD8 A;  1AHU A;  5I1V A;  1MBB A;  2GQT A;  1W1Q A;  5AE3 A;  2VFU A;  4BC9 A; 
#chains in the Genus database with same CATH homology
 2BVG A;  2VFS A;  2OAI A;  4PVK A;  1T3Q C;  4HG0 A;  3FW7 A;  4JB1 A;  3W8Z A;  3D2H A;  5FXP A;  1W1O A;  3S1E A;  5I1W A;  2Y08 A;  1W1J A;  1JRO A;  2Q85 A;  1WVE A;  5AE2 A;  3NVV B;  3HSU A;  3BW7 A;  1WYG A;  3PQB A;  4JAY A;  1JRP A;  3RJ8 A;  3SR6 B;  5HHZ A;  5FXD A;  3VTE A;  1V97 A;  3JS8 A;  1E8H A;  2EXR A;  5L6G A;  2WDW A;  4DNS A;  1UXY A;  1ZR6 A;  2Y3S A;  3LAE A;  1FIQ B;  2QPM A;  1AHZ A;  3RJA A;  1SB3 B;  5G5G B;  1I19 A;  2VFV A;  3S1F A;  3POP A;  2AXR A;  1DZN A;  4ML8 A;  1VDV A;  3NRZ B;  5ADZ A;  1N63 C;  3C0P A;  4PWB A;  1AHV A;  1W1R A;  2Y3R A;  3AMZ A;  3GSY A;  2W3S A;  3DQ0 A;  4BBY A;  2Q4W A;  3EUB 3;  3S1C A;  3AM9 A;  4ZOH B;  1WVF A;  4BCA A;  3NS1 B;  3LLB A;  1N61 C;  2P13 A;  1VAO A;  3DED A;  5L6F A;  4PYT A;  2PLI A;  2I0K A;  4OAL A;  1E8F A;  1FO4 A;  2O3G A;  2E3T A;  2W3R A;  1N5W C;  5AE1 A;  3B9J B;  1W1L A;  4PVJ A;  3TX1 A;  1E8G A;  2NQW A;  3NVY B;  2MBR A;  3D2J A;  1DIQ A;  5FXF A;  3AN1 A;  1E0Y A;  1FFV C;  5HMR A;  1HSK A;  1ZXI C;  2P4P A;  4PVE A;  1N62 C;  2VAO A;  3ETR B;  1N60 C;  1W1M A;  3HRD C;  5G5H B;  3FW8 A;  3TSH A;  2R2Z A;  3W8X A;  1W1K A;  4MLA A;  2QKN A;  1RM6 B;  1FFU C;  3FW9 A;  3NVW B;  2GQU A;  2UUU A;  3PM9 A;  3TSJ A;  4XLO A;  2YVS A;  5FXE A;  3S1D A;  1DII A;  2VFR A;  2P3H A;  3FWA A;  4PVH A;  3W8W A;  5D79 A;  4EC3 A;  2W54 A;  2BVH A;  5HQX A;  2RK5 A;  1W1S A;  3NVZ B;  1N5X A;  3I99 A;  2PLS A;  1QLU A;  2IPI A;  3KJM A;  5K8E A;  2Y4G A;  4O95 A;  1F0X A;  2W55 A;  4PZF A;  3D2D A;  2UUV A;  5AWV A;  2R8D A;  1QLT A;  2BVF A;  1MBT A;  2VFT A;  4BC7 A;  4PWC A;  4UD8 A;  1AHU A;  5I1V A;  1MBB A;  2GQT A;  1W1Q A;  5AE3 A;  2VFU A;  4BC9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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