1W1LA

Structure of the octameric flavoenzyme vanillyl-alcohol oxidase: phe454tyr mutant
Total Genus 170
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
170
sequence length
555
structure length
550
Chain Sequence
EFRPLTLPPKLSLSDFNEFIQDIIRIVGSENVEVISVDGSYMKPTHTHDPHHVMDQDYFLASAIVAPRNVADVQSIVGLANKFSFPLWPISIGRNSGYGGAAPRVSGSVVLDMGKNMNRVLEVNVEGAYCVVEPGVTYHDLHNYLEANNLRDKLWLDVPDLGGGSVLGNAVERGVGYTPYGDHWMMHSGMEVVLANGELLRTGMGALPDPKRPETMGLKPEDQPWSKIAHLFPYGFGPYIDGLFSQSNMGIVTKIGIWLMPNPRGYQSYLITLPKDGDLKQAVDIIRPLRLGMALQNVPTIRHILLDAAVLGDKRSYSSRTEPLSDEELDKIAKQLNLGRWNFYGALYGPEPIRRVLWETIKDAFSAIPGVKFYFPEDTPENSVLRVRDKTMQGIPTYDELKWIDWLPNGAHLFFSPIAKVSGEDAMMQYAVTKKRCQEAGLDYIGTFTVGMREMHHIVCIVFNKKDLIQKRKVQWLMRTLIDDCAANGWGEYRTHLAFMDQIMETYNWNNSSFLRFNEVLKNAVDPNGIIAPGKSGVWPSQYSHVTWKL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Oxidoreductase
molecule keywords VANILLYL-ALCOHOL OXIDASE
publication title Laboratory-Evolved Vanillyl-Alcohol Oxidase Produces Natural Vanillin
pubmed doi rcsb
source organism Penicillium simplicissimum
total genus 170
structure length 550
sequence length 555
chains with identical sequence B
ec nomenclature ec 1.1.3.38: Vanillyl-alcohol oxidase.
pdb deposition date 2004-06-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01565 FAD_binding_4 FAD binding domain
A PF02913 FAD-oxidase_C FAD linked oxidases, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.45.10 Mainly Alpha Orthogonal Bundle Vanillyl-alcohol Oxidase; Chain A, domain 4 Vanillyl-alcohol Oxidase; Chain A, domain 4 1w1lA04
3.30.43.10 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2 1w1lA01
3.30.465.10 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 1w1lA02
3.40.462.10 Alpha Beta 3-Layer(aba) Sandwich Vanillyl-alcohol Oxidase; Chain A, domain 3 FAD-linked oxidases, C-terminal domain 1w1lA03
2YVSA 1N5WC 4JB1A 1UXYA 5HQXA 5AE1A 5G5HB 5HHZA 1QLUA 2W54A 1T3QC 3LAEA 1DIIA 1FFUC 1FO4A 5AE3A 1QLTA 3DQ0A 3HRDC 1N62C 1E8GA 2QKNA 3NVYB 3AM9A 4PWCA 5D79A 1W1SA 4XLOA 1FIQB 1VDVA 1E8FA 1RM6B 2VAOA 4PVKA 2W55A 2VFVA 4OALA 2R2ZA 1AHZA 3NVWB 3S1DA 1JRPA 3TX1A 3W8ZA 3W8XA 1W1QA 3NRZB 2OAIA 1WVEA 2O3GA 3PM9A 4BC9A 1ZXIC 1N5XA 2P3HA 2PLIA 3BW7A 1E8HA 3FW7A 1N61C 3TSHA 1WVFA 3S1CA 1JROA 2RK5A 1W1JA 3S1EA 3W8WA 1AHVA 2VFTA 3S1FA 2BVHA 5FXFA 2VFSA 1I19A 2VFUA 3EUB3 2P4PA 1N63C 3FW9A 2PLSA 2P13A 4ML8A 3C0PA 3ETRB 1MBTA 5ADZA 5AE2A 2W3RA 3NS1B 3AN1A 3FW8A 5HMRA 3NVVB 4BBYA 1ZR6A 2W3SA 2BVFA 2EXRA 3I99A 2GQUA 1W1MA 1HSKA 1F0XA 1N60C 2I0KA 2Q85A 1V97A 4JAYA 2R8DA 1DIQA 4MLAA 4PYTA 2E3TA 3NVZB 5FXEA 1W1KA 2Q4WA 3D2HA 3GSYA 1SB3B 4PVJA 1W1OA 1DZNA 4O95A 2NQWA 4BC7A 2MBRA 3DEDA 5G5GB 4PWBA 3B9JB 3LLBA 2VFRA 3KJMA 3SR6B 1MBBA 1W1RA 3TSJA 4PVEA 4HG0A 4ZOHB 5FXDA 5FXPA 3VTEA 3D2DA 4DNSA 2AXRA 4PVHA 1AHUA 3JS8A 1W1LA 1E0YA 4PZFA 2BVGA 4EC3A 1WYGA 2QPMA 2GQTA 3AMZA 1FFVC 3D2JA 4BCAA 4UD8A 1VAOA 3FWAA
chains in the Genus database with same CATH superfamily
2YVSA 1N5WC 4JB1A 1UXYA 5HQXA 5AE1A 5G5HB 5AWVA 5HHZA 1QLUA 2W54A 1T3QC 2Y08A 3LAEA 1DIIA 1FFUC 1FO4A 5AE3A 1QLTA 3EJBB 3DQ0A 3HRDC 1N62C 1E8GA 3PQBA 2QKNA 3NVYB 3HSUA 3AM9A 2Y3SA 4PWCA 5D79A 1W1SA 4XLOA 1FIQB 1VDVA 1E8FA 1RM6B 2IPIA 2VAOA 4PVKA 5I1WA 2W55A 2VFVA 4OALA 2R2ZA 1AHZA 3NVWB 3S1DA 3POPA 1JRPA 3TX1A 3W8ZA 3W8XA 1W1QA 3NRZB 2OAIA 5L6GA 1WVEA 2O3GA 3PM9A 4BC9A 1ZXIC 1N5XA 2P3HA 2PLIA 3BW7A 1E8HA 3FW7A 5I1VA 1N61C 3TSHA 1WVFA 3S1CA 1JROA 2RK5A 1W1JA 3S1EA 3EJEB 3W8WA 1AHVA 2VFTA 3S1FA 2BVHA 5FXFA 2VFSA 3EJDB 3RJ8A 1I19A 2VFUA 3RJAA 3EUB3 2P4PA 1N63C 3FW9A 2PLSA 2P13A 4ML8A 3C0PA 3ETRB 1MBTA 5ADZA 5K8EA 5AE2A 2W3RA 3NS1B 2WDWA 3AN1A 3FW8A 5HMRA 3NVVB 4BBYA 1ZR6A 2W3SA 2BVFA 2EXRA 3I99A 2GQUA 1W1MA 1HSKA 1F0XA 1N60C 5L6FA 2I0KA 2Q85A 1V97A 4JAYA 2R8DA 1DIQA 4MLAA 4PYTA 2Y4GA 2E3TA 3NVZB 5FXEA 1W1KA 2Q4WA 3D2HA 3GSYA 1SB3B 4PVJA 1W1OA 1DZNA 4O95A 2NQWA 4BC7A 2MBRA 3DEDA 5G5GB 4PWBA 3B9JB 3LLBA 2VFRA 3KJMA 3SR6B 2UUUA 1MBBA 1W1RA 3TSJA 4PVEA 4HG0A 4ZOHB 5FXDA 5FXPA 3VTEA 2Y3RA 3D2DA 4DNSA 2AXRA 4PVHA 1AHUA 3JS8A 1W1LA 1E0YA 2UUVA 4PZFA 2BVGA 4EC3A 1WYGA 2QPMA 2GQTA 3AMZA 1FFVC 3D2JA 4BCAA 4UD8A 1VAOA 3FWAA
chains in the Genus database with same CATH topology
2YVSA 1N5WC 4JB1A 1UXYA 5HQXA 5AE1A 5G5HB 5AWVA 5HHZA 1QLUA 2W54A 1T3QC 2Y08A 3LAEA 1DIIA 1FFUC 1FO4A 5AE3A 1QLTA 3DQ0A 3HRDC 1N62C 1E8GA 3PQBA 2QKNA 3NVYB 3HSUA 3AM9A 2Y3SA 4PWCA 5D79A 1W1SA 4XLOA 1FIQB 1VDVA 1E8FA 1RM6B 2IPIA 2VAOA 4PVKA 5I1WA 2W55A 2VFVA 4OALA 2R2ZA 1AHZA 3NVWB 3S1DA 3POPA 1JRPA 3TX1A 3W8ZA 3W8XA 1W1QA 3NRZB 2OAIA 5L6GA 1WVEA 2O3GA 3PM9A 4BC9A 1ZXIC 1N5XA 2P3HA 2PLIA 3BW7A 1E8HA 3FW7A 5I1VA 1N61C 3TSHA 1WVFA 3S1CA 1JROA 2RK5A 1W1JA 3S1EA 3W8WA 1AHVA 2VFTA 3S1FA 2BVHA 5FXFA 2VFSA 3RJ8A 1I19A 2VFUA 3RJAA 3EUB3 2P4PA 1N63C 3FW9A 2PLSA 2P13A 4ML8A 3C0PA 3ETRB 1MBTA 5ADZA 5K8EA 5AE2A 2W3RA 3NS1B 2WDWA 3AN1A 3FW8A 5HMRA 3NVVB 4BBYA 1ZR6A 2W3SA 2BVFA 2EXRA 3I99A 2GQUA 1W1MA 1HSKA 1F0XA 1N60C 5L6FA 2I0KA 2Q85A 1V97A 4JAYA 2R8DA 1DIQA 4MLAA 4PYTA 2Y4GA 2E3TA 3NVZB 5FXEA 1W1KA 2Q4WA 3D2HA 3GSYA 1SB3B 4PVJA 1W1OA 1DZNA 4O95A 2NQWA 4BC7A 2MBRA 3DEDA 5G5GB 4PWBA 3B9JB 3LLBA 2VFRA 3KJMA 3SR6B 2UUUA 1MBBA 1W1RA 3TSJA 4PVEA 4HG0A 4ZOHB 5FXDA 5FXPA 3VTEA 2Y3RA 3D2DA 4DNSA 2AXRA 4PVHA 1AHUA 3JS8A 1W1LA 1E0YA 2UUVA 4PZFA 2BVGA 4EC3A 1WYGA 2QPMA 2GQTA 3AMZA 1FFVC 3D2JA 4BCAA 4UD8A 1VAOA 3FWAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2YVS A;  1N5W C;  4JB1 A;  1UXY A;  5HQX A;  5AE1 A;  5G5H B;  5HHZ A;  1QLU A;  2W54 A;  1T3Q C;  3LAE A;  1DII A;  1FFU C;  1FO4 A;  5AE3 A;  1QLT A;  3DQ0 A;  3HRD C;  1N62 C;  1E8G A;  2QKN A;  3NVY B;  3AM9 A;  4PWC A;  5D79 A;  1W1S A;  4XLO A;  1FIQ B;  1VDV A;  1E8F A;  1RM6 B;  2VAO A;  4PVK A;  2W55 A;  2VFV A;  4OAL A;  2R2Z A;  1AHZ A;  3NVW B;  3S1D A;  1JRP A;  3TX1 A;  3W8Z A;  3W8X A;  1W1Q A;  3NRZ B;  2OAI A;  1WVE A;  2O3G A;  3PM9 A;  4BC9 A;  1ZXI C;  1N5X A;  2P3H A;  2PLI A;  3BW7 A;  1E8H A;  3FW7 A;  1N61 C;  3TSH A;  1WVF A;  3S1C A;  1JRO A;  2RK5 A;  1W1J A;  3S1E A;  3W8W A;  1AHV A;  2VFT A;  3S1F A;  2BVH A;  5FXF A;  2VFS A;  1I19 A;  2VFU A;  3EUB 3;  2P4P A;  1N63 C;  3FW9 A;  2PLS A;  2P13 A;  4ML8 A;  3C0P A;  3ETR B;  1MBT A;  5ADZ A;  5AE2 A;  2W3R A;  3NS1 B;  3AN1 A;  3FW8 A;  5HMR A;  3NVV B;  4BBY A;  1ZR6 A;  2W3S A;  2BVF A;  2EXR A;  3I99 A;  2GQU A;  1W1M A;  1HSK A;  1F0X A;  1N60 C;  2I0K A;  2Q85 A;  1V97 A;  4JAY A;  2R8D A;  1DIQ A;  4MLA A;  4PYT A;  2E3T A;  3NVZ B;  5FXE A;  1W1K A;  2Q4W A;  3D2H A;  3GSY A;  1SB3 B;  4PVJ A;  1W1O A;  1DZN A;  4O95 A;  2NQW A;  4BC7 A;  2MBR A;  3DED A;  5G5G B;  4PWB A;  3B9J B;  3LLB A;  2VFR A;  3KJM A;  3SR6 B;  1MBB A;  1W1R A;  3TSJ A;  4PVE A;  4HG0 A;  4ZOH B;  5FXD A;  5FXP A;  3VTE A;  3D2D A;  4DNS A;  2AXR A;  4PVH A;  1AHU A;  3JS8 A;  1W1L A;  1E0Y A;  4PZF A;  2BVG A;  4EC3 A;  1WYG A;  2QPM A;  2GQT A;  3AMZ A;  1FFV C;  3D2J A;  4BCA A;  4UD8 A;  1VAO A;  3FWA A; 
#chains in the Genus database with same CATH topology
 2YVS A;  1N5W C;  4JB1 A;  1UXY A;  5HQX A;  5AE1 A;  5G5H B;  5AWV A;  5HHZ A;  1QLU A;  2W54 A;  1T3Q C;  2Y08 A;  3LAE A;  1DII A;  1FFU C;  1FO4 A;  5AE3 A;  1QLT A;  3EJB B;  3DQ0 A;  3HRD C;  1N62 C;  1E8G A;  3PQB A;  2QKN A;  3NVY B;  3HSU A;  3AM9 A;  2Y3S A;  4PWC A;  5D79 A;  1W1S A;  4XLO A;  1FIQ B;  1VDV A;  1E8F A;  1RM6 B;  2IPI A;  2VAO A;  4PVK A;  5I1W A;  2W55 A;  2VFV A;  4OAL A;  2R2Z A;  1AHZ A;  3NVW B;  3S1D A;  3POP A;  1JRP A;  3TX1 A;  3W8Z A;  3W8X A;  1W1Q A;  3NRZ B;  2OAI A;  5L6G A;  1WVE A;  2O3G A;  3PM9 A;  4BC9 A;  1ZXI C;  1N5X A;  2P3H A;  2PLI A;  3BW7 A;  1E8H A;  3FW7 A;  5I1V A;  1N61 C;  3TSH A;  1WVF A;  3S1C A;  1JRO A;  2RK5 A;  1W1J A;  3S1E A;  3EJE B;  3W8W A;  1AHV A;  2VFT A;  3S1F A;  2BVH A;  5FXF A;  2VFS A;  3EJD B;  3RJ8 A;  1I19 A;  2VFU A;  3RJA A;  3EUB 3;  2P4P A;  1N63 C;  3FW9 A;  2PLS A;  2P13 A;  4ML8 A;  3C0P A;  3ETR B;  1MBT A;  5ADZ A;  5K8E A;  5AE2 A;  2W3R A;  3NS1 B;  2WDW A;  3AN1 A;  3FW8 A;  5HMR A;  3NVV B;  4BBY A;  1ZR6 A;  2W3S A;  2BVF A;  2EXR A;  3I99 A;  2GQU A;  1W1M A;  1HSK A;  1F0X A;  1N60 C;  5L6F A;  2I0K A;  2Q85 A;  1V97 A;  4JAY A;  2R8D A;  1DIQ A;  4MLA A;  4PYT A;  2Y4G A;  2E3T A;  3NVZ B;  5FXE A;  1W1K A;  2Q4W A;  3D2H A;  3GSY A;  1SB3 B;  4PVJ A;  1W1O A;  1DZN A;  4O95 A;  2NQW A;  4BC7 A;  2MBR A;  3DED A;  5G5G B;  4PWB A;  3B9J B;  3LLB A;  2VFR A;  3KJM A;  3SR6 B;  2UUU A;  1MBB A;  1W1R A;  3TSJ A;  4PVE A;  4HG0 A;  4ZOH B;  5FXD A;  5FXP A;  3VTE A;  2Y3R A;  3D2D A;  4DNS A;  2AXR A;  4PVH A;  1AHU A;  3JS8 A;  1W1L A;  1E0Y A;  2UUV A;  4PZF A;  2BVG A;  4EC3 A;  1WYG A;  2QPM A;  2GQT A;  3AMZ A;  1FFV C;  3D2J A;  4BCA A;  4UD8 A;  1VAO A;  3FWA A; 
#chains in the Genus database with same CATH homology
 2YVS A;  1N5W C;  4JB1 A;  1UXY A;  5HQX A;  5AE1 A;  5G5H B;  5AWV A;  5HHZ A;  1QLU A;  2W54 A;  1T3Q C;  2Y08 A;  3LAE A;  1DII A;  1FFU C;  1FO4 A;  5AE3 A;  1QLT A;  3DQ0 A;  3HRD C;  1N62 C;  1E8G A;  3PQB A;  2QKN A;  3NVY B;  3HSU A;  3AM9 A;  2Y3S A;  4PWC A;  5D79 A;  1W1S A;  4XLO A;  1FIQ B;  1VDV A;  1E8F A;  1RM6 B;  2IPI A;  2VAO A;  4PVK A;  5I1W A;  2W55 A;  2VFV A;  4OAL A;  2R2Z A;  1AHZ A;  3NVW B;  3S1D A;  3POP A;  1JRP A;  3TX1 A;  3W8Z A;  3W8X A;  1W1Q A;  3NRZ B;  2OAI A;  5L6G A;  1WVE A;  2O3G A;  3PM9 A;  4BC9 A;  1ZXI C;  1N5X A;  2P3H A;  2PLI A;  3BW7 A;  1E8H A;  3FW7 A;  5I1V A;  1N61 C;  3TSH A;  1WVF A;  3S1C A;  1JRO A;  2RK5 A;  1W1J A;  3S1E A;  3W8W A;  1AHV A;  2VFT A;  3S1F A;  2BVH A;  5FXF A;  2VFS A;  3RJ8 A;  1I19 A;  2VFU A;  3RJA A;  3EUB 3;  2P4P A;  1N63 C;  3FW9 A;  2PLS A;  2P13 A;  4ML8 A;  3C0P A;  3ETR B;  1MBT A;  5ADZ A;  5K8E A;  5AE2 A;  2W3R A;  3NS1 B;  2WDW A;  3AN1 A;  3FW8 A;  5HMR A;  3NVV B;  4BBY A;  1ZR6 A;  2W3S A;  2BVF A;  2EXR A;  3I99 A;  2GQU A;  1W1M A;  1HSK A;  1F0X A;  1N60 C;  5L6F A;  2I0K A;  2Q85 A;  1V97 A;  4JAY A;  2R8D A;  1DIQ A;  4MLA A;  4PYT A;  2Y4G A;  2E3T A;  3NVZ B;  5FXE A;  1W1K A;  2Q4W A;  3D2H A;  3GSY A;  1SB3 B;  4PVJ A;  1W1O A;  1DZN A;  4O95 A;  2NQW A;  4BC7 A;  2MBR A;  3DED A;  5G5G B;  4PWB A;  3B9J B;  3LLB A;  2VFR A;  3KJM A;  3SR6 B;  2UUU A;  1MBB A;  1W1R A;  3TSJ A;  4PVE A;  4HG0 A;  4ZOH B;  5FXD A;  5FXP A;  3VTE A;  2Y3R A;  3D2D A;  4DNS A;  2AXR A;  4PVH A;  1AHU A;  3JS8 A;  1W1L A;  1E0Y A;  2UUV A;  4PZF A;  2BVG A;  4EC3 A;  1WYG A;  2QPM A;  2GQT A;  3AMZ A;  1FFV C;  3D2J A;  4BCA A;  4UD8 A;  1VAO A;  3FWA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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