4PZFA

Berberine bridge enzyme g164a variant, a reticuline dehydrogenase
Total Genus 163
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
163
sequence length
498
structure length
498
Chain Sequence
DLLSCLTFNGVRNHTVFSADSDSDFNRFLHLSIQNPLFQNSLISKPSAIILPGSKEELSNTIRCIRKGSWTIRLRSGGHSYEGLSYTSDTPFILIDLMNLNRVSIDLESETAWVESGSTLGELYYAITESSSKLGFTAAWCPTVGTGGHISGGGFGMMSRKYGLAADNVVDAILIDANGAILDRQAMGEDVFWAIRGGGGGVWGAIYAWKIKLLPVPEKVTVFRVTKNVAIDEATSLLHKWQFVAEELEEDFTLSVLGGADEKQVWLTMLGFHFGLKTVAKSTFDLLFPELGLVEEDYLEMSWGESFAYLAGLETVSQLNNRFLKFDERAFKTKVDLTKEPLPSKAFYGLLERLSKEPNGFIALNGFGGQMSKISSDFTPFPHRSGTRLMVEYIVAWNQSEQKKKTEFLDWLEKVYEFMKPFVSKNPRLGYVNHIDLDLGGIDWGNKTVVNNAIEISRSWGESYFLSNYERLIRAKTLIDPNNVFNHPQSIPPMANFD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Oxidoreductase
molecule keywords Reticuline oxidase
publication title Rationally engineered flavin-dependent oxidase reveals steric control of dioxygen reduction.
pubmed doi rcsb
source organism Eschscholzia californica
total genus 163
structure length 498
sequence length 498
chains with identical sequence B, C, D
ec nomenclature ec 1.21.3.3: Reticuline oxidase.
pdb deposition date 2014-03-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01565 FAD_binding_4 FAD binding domain
A PF08031 BBE Berberine and berberine like
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.43.10 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2 4pzfA01
3.30.465.50 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 4pzfA02
3.40.462.20 Alpha Beta 3-Layer(aba) Sandwich Vanillyl-alcohol Oxidase; Chain A, domain 3 Vanillyl-alcohol Oxidase; Chain A, domain 3 4pzfA03
2GQUA 1T3QC 1E8GA 3ETRB 1F0XA 1W1QA 1WVEA 1DZNA 2W3SA 3D2JA 2MBRA 3FW7A 1FFVC 1FO4A 3AM9A 3JS8A 4XLOA 4DNSA 3AMZA 3VTEA 1MBTA 2QPMA 2IPIA 4BC9A 4PWBA 1W1RA 3RJAA 4EC3A 4PWCA 1WVFA 2QKNA 5FXFA 5I1VA 1UXYA 4PYTA 5FXDA 1MBBA 1N62C 5K8EA 1W1MA 2Y08A 5HMRA 3HSUA 4PVEA 3PM9A 2WDWA 4O95A 4BCAA 3BW7A 3I99A 1WYGA 2GQTA 2VFTA 1N63C 3NVZB 1W1OA 3B9JB 1AHUA 5HQXA 1DIQA 5D79A 1FFUC 1FIQB 1W1SA 5AE2A 1N5XA 2W3RA 5ADZA 1V97A 4PVJA 2VFRA 1W1JA 4BBYA 4ML8A 5FXEA 2BVHA 2VFVA 4UD8A 2W54A 5AE3A 1HSKA 2VFUA 3FWAA 3SR6B 4JAYA 5HHZA 1AHVA 2VAOA 3TSHA 3RJ8A 3DQ0A 3W8WA 3GSYA 3KJMA 1I19A 1N60C 4JB1A 1QLUA 1VDVA 1JROA 2Y4GA 1W1LA 1E0YA 2Q4WA 5AE1A 3FW8A 1W1KA 3TSJA 2Y3SA 1ZXIC 1E8HA 4PZFA 2AXRA 1VAOA 2W55A 3POPA 1AHZA 3W8ZA 1DIIA 3D2DA 3C0PA 4PVKA 2EXRA 3S1EA 5FXPA 4MLAA 4OALA 3S1DA 2E3TA 1QLTA 3NRZB 3AN1A 5AWVA 3PQBA 1N5WC 3TX1A 3S1CA 1N61C 4ZOHB 2I0KA 2VFSA 2Q85A 2Y3RA 5I1WA 4PVHA 3EUB3 2BVFA 3S1FA 3W8XA 5L6GA 1ZR6A 3FW9A 4BC7A 5L6FA 3D2HA 3NS1B 1E8FA 2BVGA
chains in the Genus database with same CATH superfamily
2GQUA 1T3QC 1E8GA 3ETRB 2UUVA 1F0XA 1W1QA 2NQWA 1WVEA 1RM6B 1DZNA 2W3SA 2O3GA 3D2JA 2MBRA 3FW7A 1FFVC 1FO4A 3AM9A 3JS8A 4XLOA 4DNSA 3AMZA 3VTEA 1MBTA 2QPMA 3NVVB 2IPIA 4BC9A 2R2ZA 4PWBA 1W1RA 2P13A 3RJAA 4EC3A 4PWCA 1WVFA 2QKNA 5FXFA 3DEDA 5I1VA 1UXYA 3NVYB 4PYTA 5FXDA 1MBBA 1N62C 5K8EA 1W1MA 2Y08A 5G5GB 5HMRA 3HSUA 4PVEA 2YVSA 3PM9A 2WDWA 4O95A 4BCAA 3BW7A 3I99A 1WYGA 2GQTA 2VFTA 1N63C 3NVZB 1W1OA 2P3HA 3B9JB 1AHUA 5HQXA 1DIQA 5D79A 1FFUC 1FIQB 1W1SA 5AE2A 1SB3B 1N5XA 2W3RA 5ADZA 1V97A 4PVJA 2VFRA 1W1JA 4BBYA 3EJEB 4ML8A 5FXEA 2BVHA 2VFVA 4UD8A 2W54A 5AE3A 1HSKA 2VFUA 3FWAA 2R8DA 3SR6B 4JAYA 5HHZA 1AHVA 2PLIA 2VAOA 3TSHA 3RJ8A 3DQ0A 3W8WA 3GSYA 3KJMA 3LLBA 1I19A 1N60C 4JB1A 1QLUA 2PLSA 3EJDB 1VDVA 1JROA 2Y4GA 1W1LA 1E0YA 2Q4WA 5AE1A 3FW8A 1W1KA 3TSJA 2Y3SA 1ZXIC 4HG0A 1E8HA 4PZFA 2AXRA 1VAOA 2W55A 3POPA 1AHZA 3W8ZA 1DIIA 2UUUA 3D2DA 3C0PA 4PVKA 2EXRA 1JRPA 3S1EA 5FXPA 4MLAA 4OALA 3S1DA 2OAIA 2E3TA 1QLTA 3EJBB 2RK5A 3NRZB 3AN1A 5AWVA 5G5HB 3PQBA 1N5WC 3TX1A 3S1CA 1N61C 4ZOHB 2I0KA 2VFSA 2Q85A 2Y3RA 5I1WA 3NVWB 4PVHA 3EUB3 2BVFA 3S1FA 2P4PA 3W8XA 3LAEA 5L6GA 1ZR6A 3FW9A 4BC7A 3HRDC 5L6FA 3D2HA 3NS1B 1E8FA 2BVGA
chains in the Genus database with same CATH topology
2GQUA 1T3QC 1E8GA 3ETRB 2UUVA 1F0XA 1W1QA 2NQWA 1WVEA 1RM6B 1DZNA 2W3SA 2O3GA 3D2JA 2MBRA 3FW7A 1FFVC 1FO4A 3AM9A 3JS8A 4XLOA 4DNSA 3AMZA 3VTEA 1MBTA 2QPMA 3NVVB 2IPIA 4BC9A 2R2ZA 4PWBA 1W1RA 2P13A 3RJAA 4EC3A 4PWCA 1WVFA 2QKNA 5FXFA 3DEDA 5I1VA 1UXYA 4PYTA 3NVYB 5FXDA 1MBBA 1N62C 5K8EA 1W1MA 2Y08A 5G5GB 5HMRA 3HSUA 4PVEA 2YVSA 3PM9A 2WDWA 4O95A 4BCAA 3BW7A 3I99A 1WYGA 2GQTA 2VFTA 1N63C 3NVZB 1W1OA 2P3HA 3B9JB 1AHUA 5HQXA 1DIQA 5D79A 1FFUC 1FIQB 1W1SA 5AE2A 1SB3B 1N5XA 2W3RA 5ADZA 1V97A 4PVJA 2VFRA 1W1JA 4BBYA 4ML8A 5FXEA 2BVHA 2VFVA 4UD8A 2W54A 5AE3A 1HSKA 2VFUA 3FWAA 2R8DA 3SR6B 4JAYA 5HHZA 1AHVA 2PLIA 2VAOA 3TSHA 3RJ8A 3DQ0A 3W8WA 3GSYA 3KJMA 3LLBA 1I19A 1N60C 4JB1A 1QLUA 2PLSA 1VDVA 1JROA 2Y4GA 1W1LA 1E0YA 2Q4WA 5AE1A 3FW8A 1W1KA 3TSJA 2Y3SA 1ZXIC 4HG0A 1E8HA 4PZFA 2AXRA 1VAOA 2W55A 3POPA 1AHZA 3W8ZA 1DIIA 2UUUA 3D2DA 3C0PA 4PVKA 2EXRA 1JRPA 3S1EA 5FXPA 4MLAA 4OALA 3S1DA 2OAIA 2E3TA 1QLTA 2RK5A 3NRZB 3AN1A 5AWVA 5G5HB 3PQBA 1N5WC 3TX1A 3S1CA 1N61C 4ZOHB 2I0KA 2VFSA 2Q85A 2Y3RA 5I1WA 3NVWB 4PVHA 3EUB3 2BVFA 3S1FA 2P4PA 3W8XA 3LAEA 5L6GA 1ZR6A 3FW9A 4BC7A 3HRDC 5L6FA 3D2HA 3NS1B 1E8FA 2BVGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GQU A;  1T3Q C;  1E8G A;  3ETR B;  1F0X A;  1W1Q A;  1WVE A;  1DZN A;  2W3S A;  3D2J A;  2MBR A;  3FW7 A;  1FFV C;  1FO4 A;  3AM9 A;  3JS8 A;  4XLO A;  4DNS A;  3AMZ A;  3VTE A;  1MBT A;  2QPM A;  2IPI A;  4BC9 A;  4PWB A;  1W1R A;  3RJA A;  4EC3 A;  4PWC A;  1WVF A;  2QKN A;  5FXF A;  5I1V A;  1UXY A;  4PYT A;  5FXD A;  1MBB A;  1N62 C;  5K8E A;  1W1M A;  2Y08 A;  5HMR A;  3HSU A;  4PVE A;  3PM9 A;  2WDW A;  4O95 A;  4BCA A;  3BW7 A;  3I99 A;  1WYG A;  2GQT A;  2VFT A;  1N63 C;  3NVZ B;  1W1O A;  3B9J B;  1AHU A;  5HQX A;  1DIQ A;  5D79 A;  1FFU C;  1FIQ B;  1W1S A;  5AE2 A;  1N5X A;  2W3R A;  5ADZ A;  1V97 A;  4PVJ A;  2VFR A;  1W1J A;  4BBY A;  4ML8 A;  5FXE A;  2BVH A;  2VFV A;  4UD8 A;  2W54 A;  5AE3 A;  1HSK A;  2VFU A;  3FWA A;  3SR6 B;  4JAY A;  5HHZ A;  1AHV A;  2VAO A;  3TSH A;  3RJ8 A;  3DQ0 A;  3W8W A;  3GSY A;  3KJM A;  1I19 A;  1N60 C;  4JB1 A;  1QLU A;  1VDV A;  1JRO A;  2Y4G A;  1W1L A;  1E0Y A;  2Q4W A;  5AE1 A;  3FW8 A;  1W1K A;  3TSJ A;  2Y3S A;  1ZXI C;  1E8H A;  4PZF A;  2AXR A;  1VAO A;  2W55 A;  3POP A;  1AHZ A;  3W8Z A;  1DII A;  3D2D A;  3C0P A;  4PVK A;  2EXR A;  3S1E A;  5FXP A;  4MLA A;  4OAL A;  3S1D A;  2E3T A;  1QLT A;  3NRZ B;  3AN1 A;  5AWV A;  3PQB A;  1N5W C;  3TX1 A;  3S1C A;  1N61 C;  4ZOH B;  2I0K A;  2VFS A;  2Q85 A;  2Y3R A;  5I1W A;  4PVH A;  3EUB 3;  2BVF A;  3S1F A;  3W8X A;  5L6G A;  1ZR6 A;  3FW9 A;  4BC7 A;  5L6F A;  3D2H A;  3NS1 B;  1E8F A;  2BVG A; 
#chains in the Genus database with same CATH topology
 2GQU A;  1T3Q C;  1E8G A;  3ETR B;  2UUV A;  1F0X A;  1W1Q A;  2NQW A;  1WVE A;  1RM6 B;  1DZN A;  2W3S A;  2O3G A;  3D2J A;  2MBR A;  3FW7 A;  1FFV C;  1FO4 A;  3AM9 A;  3JS8 A;  4XLO A;  4DNS A;  3AMZ A;  3VTE A;  1MBT A;  2QPM A;  3NVV B;  2IPI A;  4BC9 A;  2R2Z A;  4PWB A;  1W1R A;  2P13 A;  3RJA A;  4EC3 A;  4PWC A;  1WVF A;  2QKN A;  5FXF A;  3DED A;  5I1V A;  1UXY A;  3NVY B;  4PYT A;  5FXD A;  1MBB A;  1N62 C;  5K8E A;  1W1M A;  2Y08 A;  5G5G B;  5HMR A;  3HSU A;  4PVE A;  2YVS A;  3PM9 A;  2WDW A;  4O95 A;  4BCA A;  3BW7 A;  3I99 A;  1WYG A;  2GQT A;  2VFT A;  1N63 C;  3NVZ B;  1W1O A;  2P3H A;  3B9J B;  1AHU A;  5HQX A;  1DIQ A;  5D79 A;  1FFU C;  1FIQ B;  1W1S A;  5AE2 A;  1SB3 B;  1N5X A;  2W3R A;  5ADZ A;  1V97 A;  4PVJ A;  2VFR A;  1W1J A;  4BBY A;  3EJE B;  4ML8 A;  5FXE A;  2BVH A;  2VFV A;  4UD8 A;  2W54 A;  5AE3 A;  1HSK A;  2VFU A;  3FWA A;  2R8D A;  3SR6 B;  4JAY A;  5HHZ A;  1AHV A;  2PLI A;  2VAO A;  3TSH A;  3RJ8 A;  3DQ0 A;  3W8W A;  3GSY A;  3KJM A;  3LLB A;  1I19 A;  1N60 C;  4JB1 A;  1QLU A;  2PLS A;  3EJD B;  1VDV A;  1JRO A;  2Y4G A;  1W1L A;  1E0Y A;  2Q4W A;  5AE1 A;  3FW8 A;  1W1K A;  3TSJ A;  2Y3S A;  1ZXI C;  4HG0 A;  1E8H A;  4PZF A;  2AXR A;  1VAO A;  2W55 A;  3POP A;  1AHZ A;  3W8Z A;  1DII A;  2UUU A;  3D2D A;  3C0P A;  4PVK A;  2EXR A;  1JRP A;  3S1E A;  5FXP A;  4MLA A;  4OAL A;  3S1D A;  2OAI A;  2E3T A;  1QLT A;  3EJB B;  2RK5 A;  3NRZ B;  3AN1 A;  5AWV A;  5G5H B;  3PQB A;  1N5W C;  3TX1 A;  3S1C A;  1N61 C;  4ZOH B;  2I0K A;  2VFS A;  2Q85 A;  2Y3R A;  5I1W A;  3NVW B;  4PVH A;  3EUB 3;  2BVF A;  3S1F A;  2P4P A;  3W8X A;  3LAE A;  5L6G A;  1ZR6 A;  3FW9 A;  4BC7 A;  3HRD C;  5L6F A;  3D2H A;  3NS1 B;  1E8F A;  2BVG A; 
#chains in the Genus database with same CATH homology
 2GQU A;  1T3Q C;  1E8G A;  3ETR B;  2UUV A;  1F0X A;  1W1Q A;  2NQW A;  1WVE A;  1RM6 B;  1DZN A;  2W3S A;  2O3G A;  3D2J A;  2MBR A;  3FW7 A;  1FFV C;  1FO4 A;  3AM9 A;  3JS8 A;  4XLO A;  4DNS A;  3AMZ A;  3VTE A;  1MBT A;  2QPM A;  3NVV B;  2IPI A;  4BC9 A;  2R2Z A;  4PWB A;  1W1R A;  2P13 A;  3RJA A;  4EC3 A;  4PWC A;  1WVF A;  2QKN A;  5FXF A;  3DED A;  5I1V A;  1UXY A;  4PYT A;  3NVY B;  5FXD A;  1MBB A;  1N62 C;  5K8E A;  1W1M A;  2Y08 A;  5G5G B;  5HMR A;  3HSU A;  4PVE A;  2YVS A;  3PM9 A;  2WDW A;  4O95 A;  4BCA A;  3BW7 A;  3I99 A;  1WYG A;  2GQT A;  2VFT A;  1N63 C;  3NVZ B;  1W1O A;  2P3H A;  3B9J B;  1AHU A;  5HQX A;  1DIQ A;  5D79 A;  1FFU C;  1FIQ B;  1W1S A;  5AE2 A;  1SB3 B;  1N5X A;  2W3R A;  5ADZ A;  1V97 A;  4PVJ A;  2VFR A;  1W1J A;  4BBY A;  4ML8 A;  5FXE A;  2BVH A;  2VFV A;  4UD8 A;  2W54 A;  5AE3 A;  1HSK A;  2VFU A;  3FWA A;  2R8D A;  3SR6 B;  4JAY A;  5HHZ A;  1AHV A;  2PLI A;  2VAO A;  3TSH A;  3RJ8 A;  3DQ0 A;  3W8W A;  3GSY A;  3KJM A;  3LLB A;  1I19 A;  1N60 C;  4JB1 A;  1QLU A;  2PLS A;  1VDV A;  1JRO A;  2Y4G A;  1W1L A;  1E0Y A;  2Q4W A;  5AE1 A;  3FW8 A;  1W1K A;  3TSJ A;  2Y3S A;  1ZXI C;  4HG0 A;  1E8H A;  4PZF A;  2AXR A;  1VAO A;  2W55 A;  3POP A;  1AHZ A;  3W8Z A;  1DII A;  2UUU A;  3D2D A;  3C0P A;  4PVK A;  2EXR A;  1JRP A;  3S1E A;  5FXP A;  4MLA A;  4OAL A;  3S1D A;  2OAI A;  2E3T A;  1QLT A;  2RK5 A;  3NRZ B;  3AN1 A;  5AWV A;  5G5H B;  3PQB A;  1N5W C;  3TX1 A;  3S1C A;  1N61 C;  4ZOH B;  2I0K A;  2VFS A;  2Q85 A;  2Y3R A;  5I1W A;  3NVW B;  4PVH A;  3EUB 3;  2BVF A;  3S1F A;  2P4P A;  3W8X A;  3LAE A;  5L6G A;  1ZR6 A;  3FW9 A;  4BC7 A;  3HRD C;  5L6F A;  3D2H A;  3NS1 B;  1E8F A;  2BVG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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