3VTEA

Crystal structure of tetrahydrocannabinolic acid synthase from cannabis sativa
Total Genus 159
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
159
sequence length
518
structure length
502
Chain Sequence
b'ANPRENFLKCFSKHIPNPKLVYTQHDQLYMSILNSTIQNLRFISDTTPKPLVIVTPSNNSHIQATILCSKKVGLQIRTRSGGHDAEGMSYISQVPFVVVDLRNMHSIKIDVHSQTAWVEAGATLGEVYYWINEKNENLSFPGGYCPTVGVGGHFSGGGYGALMRNYGLAADNIIDAHLVNVDGKVLDRKSMGEDLFWAIRGGGGENFGIIAAWKIKLVAVPSKSTIFSVKKNMEIHGLVKLFNKWQNIAYKYDKDLVLMTHFITKNITTTVHGYFSSIFHGGVDSLVDLMNKSFPELGIKKTDCKEFSWIDTTIFYSGVVNFKKEILLDRSAGKKTAFSIKLDYVKKPIPETAMVKILEKLYEEDVGAGMYVLYPYGGIMEEISESAIPFPHRAGIMYELWYTASWEKQEDNEKHINWVRSVYNFTTPYVSQNPRLAYLNYRDLDLGKTNHASPNNYTQARIWGEKYFGKNFNRLVKVKTKVDPNNFFRNEQSIPPLPPHHH'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Tetrahydrocannabinolic acid synthase
publication title Structure and function of 1-tetrahydrocannabinolic acid (THCA) synthase, the enzyme controlling the psychoactivity of Cannabis sativa
pubmed doi rcsb
source organism Cannabis sativa
molecule tags Oxidoreductase
total genus 159
structure length 502
sequence length 518
ec nomenclature ec 1.21.3.7: Tetrahydrocannabinolic acid synthase.
pdb deposition date 2012-05-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01565 FAD_binding_4 FAD binding domain
A PF08031 BBE Berberine and berberine like
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.43.10 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2 3vteA01
3.30.465.50 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 3vteA02
3.40.462.20 Alpha Beta 3-Layer(aba) Sandwich Vanillyl-alcohol Oxidase; Chain A, domain 3 Vanillyl-alcohol Oxidase; Chain A, domain 3 3vteA03
3C0PA 5AE3A 1W1OA 3S1FA 1WYGA 3W8WA 2BVHA 1N62C 3BW7A 1E8FA 2W3RA 5FXEA 5FXFA 5I1VA 2VFVA 5K8EA 5AWVA 2GQTA 3NS1B 3KJMA 4OALA 4PZFA 1W1JA 4UD8A 2Y4GA 4PVKA 1DIIA 2Y3RA 2Q4WA 1UXYA 3S1EA 2I0KA 4PWCA 1N60C 3NRZB 2VFTA 3FW8A 3DQ0A 1FIQB 1VAOA 3D2HA 3VTEA 5I1WA 4ZOHB 2VAOA 3FW9A 3POPA 5FXPA 1T3QC 3RJ8A 3S1CA 3PQBA 3ETRB 4BC9A 3RJAA 2EXRA 1V97A 4BBYA 4JB1A 5HHZA 1AHVA 5L6GA 4BC7A 4PWBA 3EUB3 1WVFA 1W1SA 2IPIA 1N5WC 1AHUA 3NVZB 1QLTA 2BVFA 2W3SA 1AHZA 1FFVC 2WDWA 2QPMA 5AE2A 3GSYA 1N63C 2Y08A 2VFUA 1W1RA 2VFRA 1ZXIC 2E3TA 5L6FA 1QLUA 3HSUA 2Q85A 2W54A 1W1QA 4O95A 3D2DA 4BCAA 1JROA 1E8GA 3FWAA 5D79A 3TSHA 3TSJA 1DIQA 4XLOA 3AMZA 1FO4A 1W1KA 2W55A 4PYTA 4PVJA 3B9JB 3W8XA 2Y3SA 3I99A 1HSKA 3PM9A 3D2JA 4EC3A 2MBRA 5HMRA 1MBTA 5HQXA 2VFSA 3W8ZA 1ZR6A 2QKNA 1DZNA 4DNSA 2GQUA 4PVEA 3SR6B 1W1LA 1VDVA 5AE1A 3JS8A 5FXDA 3S1DA 1WVEA 4ML8A 3TX1A 1E0YA 1MBBA 4PVHA 3AM9A 4MLAA 2AXRA 1N5XA 3AN1A 4JAYA 2BVGA 5ADZA 1I19A 3FW7A 1FFUC 1W1MA 1F0XA 1N61C 1E8HA
chains in the Genus database with same CATH superfamily
3C0PA 5AE3A 1W1OA 3S1FA 2R2ZA 1WYGA 3W8WA 2BVHA 1N62C 3BW7A 1E8FA 2UUVA 4HG0A 2W3RA 5FXEA 5FXFA 3LAEA 5I1VA 2VFVA 5K8EA 2PLSA 3NVVB 5AWVA 3EJDB 2GQTA 3NS1B 3KJMA 4OALA 4PZFA 1W1JA 4UD8A 2RK5A 4PVKA 2Y4GA 1DIIA 2Y3RA 2Q4WA 1UXYA 3S1EA 2I0KA 4PWCA 1N60C 2O3GA 3NRZB 2VFTA 3FW8A 3DQ0A 1FIQB 1VAOA 3D2HA 3VTEA 5I1WA 4ZOHB 2VAOA 3FW9A 3POPA 5FXPA 1T3QC 2UUUA 3RJ8A 3S1CA 3PQBA 3ETRB 4BC9A 3RJAA 2EXRA 1V97A 4BBYA 4JB1A 1JRPA 5HHZA 1AHVA 5L6GA 4BC7A 4PWBA 3EUB3 1WVFA 1W1SA 2IPIA 1N5WC 2PLIA 3EJEB 2P3HA 1AHUA 3NVZB 3HRDC 1QLTA 2BVFA 2W3SA 1AHZA 1FFVC 2WDWA 2YVSA 2QPMA 5AE2A 3GSYA 1N63C 2Y08A 2P13A 2VFUA 3NVYB 1W1RA 2VFRA 1ZXIC 2E3TA 5L6FA 1QLUA 3HSUA 2Q85A 2W54A 1W1QA 4O95A 3D2DA 4BCAA 1JROA 1E8GA 3FWAA 5D79A 3TSHA 3TSJA 1DIQA 4XLOA 3AMZA 2P4PA 1FO4A 1W1KA 3EJBB 2W55A 3NVWB 4PYTA 4PVJA 3B9JB 3W8XA 2Y3SA 3LLBA 3I99A 1HSKA 3PM9A 3D2JA 4EC3A 2MBRA 5HMRA 1MBTA 5HQXA 1RM6B 2VFSA 3W8ZA 1ZR6A 2QKNA 1DZNA 4DNSA 2GQUA 2NQWA 4PVEA 3SR6B 1W1LA 1VDVA 5AE1A 3JS8A 5FXDA 3S1DA 1WVEA 4ML8A 3TX1A 1E0YA 5G5GB 1MBBA 4PVHA 3AM9A 4MLAA 2AXRA 1N5XA 3AN1A 4JAYA 2BVGA 5ADZA 2R8DA 1I19A 3FW7A 1FFUC 1SB3B 1W1MA 1F0XA 1N61C 3DEDA 1E8HA 2OAIA 5G5HB
chains in the Genus database with same CATH topology
3C0PA 5AE3A 1W1OA 3S1FA 2R2ZA 1WYGA 3W8WA 2BVHA 1N62C 3BW7A 1E8FA 2UUVA 4HG0A 2W3RA 5FXEA 5FXFA 3LAEA 5I1VA 2VFVA 5K8EA 2PLSA 3NVVB 5AWVA 2GQTA 3NS1B 3KJMA 4OALA 4PZFA 1W1JA 4UD8A 2RK5A 4PVKA 2Y4GA 1DIIA 2Y3RA 2Q4WA 1UXYA 3S1EA 2I0KA 4PWCA 1N60C 2O3GA 3NRZB 2VFTA 3FW8A 3DQ0A 1FIQB 1VAOA 3D2HA 3VTEA 5I1WA 4ZOHB 2VAOA 3FW9A 3POPA 5FXPA 1T3QC 2UUUA 3RJ8A 3S1CA 3PQBA 3ETRB 4BC9A 3RJAA 2EXRA 1V97A 4BBYA 4JB1A 1JRPA 5HHZA 1AHVA 5L6GA 4BC7A 4PWBA 3EUB3 1WVFA 1W1SA 2IPIA 1N5WC 2PLIA 2P3HA 1AHUA 3NVZB 3HRDC 1QLTA 2BVFA 2W3SA 1AHZA 1FFVC 2WDWA 2YVSA 2QPMA 5AE2A 3GSYA 1N63C 2Y08A 2P13A 2VFUA 3NVYB 1W1RA 2VFRA 1ZXIC 2E3TA 5L6FA 1QLUA 3HSUA 2Q85A 2W54A 1W1QA 4O95A 3D2DA 4BCAA 1JROA 1E8GA 3FWAA 5D79A 3TSHA 3TSJA 1DIQA 4XLOA 3AMZA 2P4PA 1FO4A 1W1KA 2W55A 4PYTA 3NVWB 4PVJA 3B9JB 3W8XA 2Y3SA 3LLBA 3I99A 1HSKA 3PM9A 3D2JA 4EC3A 2MBRA 5HMRA 1MBTA 5HQXA 1RM6B 2VFSA 3W8ZA 1ZR6A 2QKNA 1DZNA 4DNSA 2GQUA 2NQWA 4PVEA 3SR6B 1W1LA 1VDVA 5AE1A 3JS8A 5FXDA 3S1DA 1WVEA 4ML8A 3TX1A 1E0YA 5G5GB 1MBBA 4PVHA 3AM9A 4MLAA 2AXRA 1N5XA 3AN1A 4JAYA 2BVGA 5ADZA 2R8DA 1I19A 3FW7A 1FFUC 1SB3B 1W1MA 1F0XA 1N61C 3DEDA 1E8HA 2OAIA 5G5HB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3C0P A;  5AE3 A;  1W1O A;  3S1F A;  1WYG A;  3W8W A;  2BVH A;  1N62 C;  3BW7 A;  1E8F A;  2W3R A;  5FXE A;  5FXF A;  5I1V A;  2VFV A;  5K8E A;  5AWV A;  2GQT A;  3NS1 B;  3KJM A;  4OAL A;  4PZF A;  1W1J A;  4UD8 A;  2Y4G A;  4PVK A;  1DII A;  2Y3R A;  2Q4W A;  1UXY A;  3S1E A;  2I0K A;  4PWC A;  1N60 C;  3NRZ B;  2VFT A;  3FW8 A;  3DQ0 A;  1FIQ B;  1VAO A;  3D2H A;  3VTE A;  5I1W A;  4ZOH B;  2VAO A;  3FW9 A;  3POP A;  5FXP A;  1T3Q C;  3RJ8 A;  3S1C A;  3PQB A;  3ETR B;  4BC9 A;  3RJA A;  2EXR A;  1V97 A;  4BBY A;  4JB1 A;  5HHZ A;  1AHV A;  5L6G A;  4BC7 A;  4PWB A;  3EUB 3;  1WVF A;  1W1S A;  2IPI A;  1N5W C;  1AHU A;  3NVZ B;  1QLT A;  2BVF A;  2W3S A;  1AHZ A;  1FFV C;  2WDW A;  2QPM A;  5AE2 A;  3GSY A;  1N63 C;  2Y08 A;  2VFU A;  1W1R A;  2VFR A;  1ZXI C;  2E3T A;  5L6F A;  1QLU A;  3HSU A;  2Q85 A;  2W54 A;  1W1Q A;  4O95 A;  3D2D A;  4BCA A;  1JRO A;  1E8G A;  3FWA A;  5D79 A;  3TSH A;  3TSJ A;  1DIQ A;  4XLO A;  3AMZ A;  1FO4 A;  1W1K A;  2W55 A;  4PYT A;  4PVJ A;  3B9J B;  3W8X A;  2Y3S A;  3I99 A;  1HSK A;  3PM9 A;  3D2J A;  4EC3 A;  2MBR A;  5HMR A;  1MBT A;  5HQX A;  2VFS A;  3W8Z A;  1ZR6 A;  2QKN A;  1DZN A;  4DNS A;  2GQU A;  4PVE A;  3SR6 B;  1W1L A;  1VDV A;  5AE1 A;  3JS8 A;  5FXD A;  3S1D A;  1WVE A;  4ML8 A;  3TX1 A;  1E0Y A;  1MBB A;  4PVH A;  3AM9 A;  4MLA A;  2AXR A;  1N5X A;  3AN1 A;  4JAY A;  2BVG A;  5ADZ A;  1I19 A;  3FW7 A;  1FFU C;  1W1M A;  1F0X A;  1N61 C;  1E8H A; 
#chains in the Genus database with same CATH topology
 3C0P A;  5AE3 A;  1W1O A;  3S1F A;  2R2Z A;  1WYG A;  3W8W A;  2BVH A;  1N62 C;  3BW7 A;  1E8F A;  2UUV A;  4HG0 A;  2W3R A;  5FXE A;  5FXF A;  3LAE A;  5I1V A;  2VFV A;  5K8E A;  2PLS A;  3NVV B;  5AWV A;  3EJD B;  2GQT A;  3NS1 B;  3KJM A;  4OAL A;  4PZF A;  1W1J A;  4UD8 A;  2RK5 A;  4PVK A;  2Y4G A;  1DII A;  2Y3R A;  2Q4W A;  1UXY A;  3S1E A;  2I0K A;  4PWC A;  1N60 C;  2O3G A;  3NRZ B;  2VFT A;  3FW8 A;  3DQ0 A;  1FIQ B;  1VAO A;  3D2H A;  3VTE A;  5I1W A;  4ZOH B;  2VAO A;  3FW9 A;  3POP A;  5FXP A;  1T3Q C;  2UUU A;  3RJ8 A;  3S1C A;  3PQB A;  3ETR B;  4BC9 A;  3RJA A;  2EXR A;  1V97 A;  4BBY A;  4JB1 A;  1JRP A;  5HHZ A;  1AHV A;  5L6G A;  4BC7 A;  4PWB A;  3EUB 3;  1WVF A;  1W1S A;  2IPI A;  1N5W C;  2PLI A;  3EJE B;  2P3H A;  1AHU A;  3NVZ B;  3HRD C;  1QLT A;  2BVF A;  2W3S A;  1AHZ A;  1FFV C;  2WDW A;  2YVS A;  2QPM A;  5AE2 A;  3GSY A;  1N63 C;  2Y08 A;  2P13 A;  2VFU A;  3NVY B;  1W1R A;  2VFR A;  1ZXI C;  2E3T A;  5L6F A;  1QLU A;  3HSU A;  2Q85 A;  2W54 A;  1W1Q A;  4O95 A;  3D2D A;  4BCA A;  1JRO A;  1E8G A;  3FWA A;  5D79 A;  3TSH A;  3TSJ A;  1DIQ A;  4XLO A;  3AMZ A;  2P4P A;  1FO4 A;  1W1K A;  3EJB B;  2W55 A;  3NVW B;  4PYT A;  4PVJ A;  3B9J B;  3W8X A;  2Y3S A;  3LLB A;  3I99 A;  1HSK A;  3PM9 A;  3D2J A;  4EC3 A;  2MBR A;  5HMR A;  1MBT A;  5HQX A;  1RM6 B;  2VFS A;  3W8Z A;  1ZR6 A;  2QKN A;  1DZN A;  4DNS A;  2GQU A;  2NQW A;  4PVE A;  3SR6 B;  1W1L A;  1VDV A;  5AE1 A;  3JS8 A;  5FXD A;  3S1D A;  1WVE A;  4ML8 A;  3TX1 A;  1E0Y A;  5G5G B;  1MBB A;  4PVH A;  3AM9 A;  4MLA A;  2AXR A;  1N5X A;  3AN1 A;  4JAY A;  2BVG A;  5ADZ A;  2R8D A;  1I19 A;  3FW7 A;  1FFU C;  1SB3 B;  1W1M A;  1F0X A;  1N61 C;  3DED A;  1E8H A;  2OAI A;  5G5H B; 
#chains in the Genus database with same CATH homology
 3C0P A;  5AE3 A;  1W1O A;  3S1F A;  2R2Z A;  1WYG A;  3W8W A;  2BVH A;  1N62 C;  3BW7 A;  1E8F A;  2UUV A;  4HG0 A;  2W3R A;  5FXE A;  5FXF A;  3LAE A;  5I1V A;  2VFV A;  5K8E A;  2PLS A;  3NVV B;  5AWV A;  2GQT A;  3NS1 B;  3KJM A;  4OAL A;  4PZF A;  1W1J A;  4UD8 A;  2RK5 A;  4PVK A;  2Y4G A;  1DII A;  2Y3R A;  2Q4W A;  1UXY A;  3S1E A;  2I0K A;  4PWC A;  1N60 C;  2O3G A;  3NRZ B;  2VFT A;  3FW8 A;  3DQ0 A;  1FIQ B;  1VAO A;  3D2H A;  3VTE A;  5I1W A;  4ZOH B;  2VAO A;  3FW9 A;  3POP A;  5FXP A;  1T3Q C;  2UUU A;  3RJ8 A;  3S1C A;  3PQB A;  3ETR B;  4BC9 A;  3RJA A;  2EXR A;  1V97 A;  4BBY A;  4JB1 A;  1JRP A;  5HHZ A;  1AHV A;  5L6G A;  4BC7 A;  4PWB A;  3EUB 3;  1WVF A;  1W1S A;  2IPI A;  1N5W C;  2PLI A;  2P3H A;  1AHU A;  3NVZ B;  3HRD C;  1QLT A;  2BVF A;  2W3S A;  1AHZ A;  1FFV C;  2WDW A;  2YVS A;  2QPM A;  5AE2 A;  3GSY A;  1N63 C;  2Y08 A;  2P13 A;  2VFU A;  3NVY B;  1W1R A;  2VFR A;  1ZXI C;  2E3T A;  5L6F A;  1QLU A;  3HSU A;  2Q85 A;  2W54 A;  1W1Q A;  4O95 A;  3D2D A;  4BCA A;  1JRO A;  1E8G A;  3FWA A;  5D79 A;  3TSH A;  3TSJ A;  1DIQ A;  4XLO A;  3AMZ A;  2P4P A;  1FO4 A;  1W1K A;  2W55 A;  4PYT A;  3NVW B;  4PVJ A;  3B9J B;  3W8X A;  2Y3S A;  3LLB A;  3I99 A;  1HSK A;  3PM9 A;  3D2J A;  4EC3 A;  2MBR A;  5HMR A;  1MBT A;  5HQX A;  1RM6 B;  2VFS A;  3W8Z A;  1ZR6 A;  2QKN A;  1DZN A;  4DNS A;  2GQU A;  2NQW A;  4PVE A;  3SR6 B;  1W1L A;  1VDV A;  5AE1 A;  3JS8 A;  5FXD A;  3S1D A;  1WVE A;  4ML8 A;  3TX1 A;  1E0Y A;  5G5G B;  1MBB A;  4PVH A;  3AM9 A;  4MLA A;  2AXR A;  1N5X A;  3AN1 A;  4JAY A;  2BVG A;  5ADZ A;  2R8D A;  1I19 A;  3FW7 A;  1FFU C;  1SB3 B;  1W1M A;  1F0X A;  1N61 C;  3DED A;  1E8H A;  2OAI A;  5G5H B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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