3VTEA

Crystal structure of tetrahydrocannabinolic acid synthase from cannabis sativa
Total Genus 159
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
159
sequence length
518
structure length
502
Chain Sequence
ANPRENFLKCFSKHIPNPKLVYTQHDQLYMSILNSTIQNLRFISDTTPKPLVIVTPSNNSHIQATILCSKKVGLQIRTRSGGHDAEGMSYISQVPFVVVDLRNMHSIKIDVHSQTAWVEAGATLGEVYYWINEKNENLSFPGGYCPTVGVGGHFSGGGYGALMRNYGLAADNIIDAHLVNVDGKVLDRKSMGEDLFWAIRGGGGENFGIIAAWKIKLVAVPSKSTIFSVKKNMEIHGLVKLFNKWQNIAYKYDKDLVLMTHFITKNITTTVHGYFSSIFHGGVDSLVDLMNKSFPELGIKKTDCKEFSWIDTTIFYSGVVNFKKEILLDRSAGKKTAFSIKLDYVKKPIPETAMVKILEKLYEEDVGAGMYVLYPYGGIMEEISESAIPFPHRAGIMYELWYTASWEKQEDNEKHINWVRSVYNFTTPYVSQNPRLAYLNYRDLDLGKTNHASPNNYTQARIWGEKYFGKNFNRLVKVKTKVDPNNFFRNEQSIPPLPPHHH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure and function of 1-tetrahydrocannabinolic acid (THCA) synthase, the enzyme controlling the psychoactivity of Cannabis sativa
pubmed doi rcsb
source organism Cannabis sativa
molecule tags Oxidoreductase
molecule keywords Tetrahydrocannabinolic acid synthase
total genus 159
structure length 502
sequence length 518
ec nomenclature ec 1.21.3.7: Tetrahydrocannabinolic acid synthase.
pdb deposition date 2012-05-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01565 FAD_binding_4 FAD binding domain
A PF08031 BBE Berberine and berberine like
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.43.10 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2 3vteA01
3.30.465.50 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 3vteA02
3.40.462.20 Alpha Beta 3-Layer(aba) Sandwich Vanillyl-alcohol Oxidase; Chain A, domain 3 Vanillyl-alcohol Oxidase; Chain A, domain 3 3vteA03
5AE2A 4ML8A 4XLOA 4PZFA 3HSUA 2Y08A 2VFUA 1N5WC 4JAYA 2BVGA 1ZXIC 5FXPA 1WVFA 1FO4A 5L6GA 1N63C 1N62C 1UXYA 1N61C 3PM9A 4DNSA 3TSJA 2BVHA 3BW7A 2Q85A 1WVEA 3I99A 1MBTA 3W8ZA 1HSKA 3ETRB 1N5XA 4BCAA 3AN1A 4PWCA 4PYTA 1FIQB 3KJMA 1I19A 2BVFA 3S1EA 3VTEA 2Y3RA 3POPA 1VAOA 2W55A 3D2DA 3PQBA 5AE1A 2E3TA 3NRZB 2GQUA 1E8HA 1VDVA 5HHZA 2QPMA 4PVEA 3D2JA 4BC9A 3W8WA 1JROA 3NVZB 1AHUA 2GQTA 3B9JB 2Y4GA 3GSYA 1F0XA 1DIQA 5I1VA 3SR6B 5FXDA 1W1SA 1N60C 5D79A 1FFVC 1T3QC 1W1MA 1QLUA 1WYGA 5FXEA 2QKNA 3DQ0A 4PVHA 1AHZA 2IPIA 2W3SA 2VFVA 1DIIA 1W1LA 5AE3A 3AMZA 2W3RA 3FW8A 5I1WA 1E0YA 4BBYA 3RJAA 3NS1B 3S1FA 3TSHA 3FW9A 1MBBA 4BC7A 4JB1A 5ADZA 5HMRA 3D2HA 4UD8A 1AHVA 3AM9A 3S1CA 5AWVA 3RJ8A 1V97A 3FWAA 1W1QA 2WDWA 1W1OA 3EUB3 1DZNA 3C0PA 3FW7A 2I0KA 3W8XA 4MLAA 3TX1A 2MBRA 1E8GA 2VAOA 4EC3A 1ZR6A 4OALA 4PVKA 4PVJA 1FFUC 5HQXA 3JS8A 5L6FA 2Q4WA 2VFTA 1QLTA 2EXRA 5FXFA 2W54A 2VFRA 1W1KA 4O95A 4PWBA 5K8EA 2AXRA 4ZOHB 1W1RA 1W1JA 2Y3SA 3S1DA 2VFSA 1E8FA
chains in the Genus database with same CATH superfamily
3EJBB 5AE2A 4ML8A 4XLOA 4PZFA 3HSUA 2Y08A 2VFUA 1N5WC 4JAYA 2BVGA 1ZXIC 3EJDB 5FXPA 1WVFA 1FO4A 5L6GA 3LAEA 1N63C 1N62C 1UXYA 1N61C 2P4PA 3PM9A 3NVWB 2R8DA 4DNSA 3TSJA 2BVHA 3BW7A 3EJEB 2P3HA 2Q85A 1WVEA 3I99A 1MBTA 3NVVB 1HSKA 3W8ZA 3DEDA 3ETRB 1N5XA 4BCAA 3AN1A 4PWCA 4PYTA 2P13A 1FIQB 3NVYB 3KJMA 1I19A 2BVFA 3S1EA 3VTEA 2Y3RA 3POPA 1VAOA 2W55A 3D2DA 3PQBA 5AE1A 2E3TA 3NRZB 2GQUA 1E8HA 1VDVA 5HHZA 2PLIA 2QPMA 4PVEA 3D2JA 2YVSA 4BC9A 3W8WA 1JROA 3NVZB 1AHUA 2GQTA 3B9JB 2Y4GA 3GSYA 1F0XA 1DIQA 2UUVA 5I1VA 3SR6B 2RK5A 5FXDA 1W1SA 1N60C 5D79A 1FFVC 1T3QC 1W1MA 1QLUA 2O3GA 1WYGA 5FXEA 2QKNA 3HRDC 3DQ0A 4PVHA 1JRPA 1AHZA 2IPIA 2W3SA 5G5HB 2VFVA 1DIIA 1W1LA 2UUUA 5AE3A 3AMZA 2W3RA 3FW8A 5I1WA 1E0YA 4BBYA 3RJAA 3NS1B 3S1FA 3TSHA 3FW9A 1MBBA 4BC7A 4JB1A 5ADZA 5HMRA 3D2HA 4UD8A 1AHVA 3AM9A 3S1CA 5AWVA 3RJ8A 1V97A 2PLSA 3FWAA 1W1QA 2WDWA 1W1OA 3EUB3 1DZNA 3C0PA 3FW7A 4HG0A 2I0KA 3W8XA 4MLAA 3TX1A 2MBRA 3LLBA 1E8GA 2VAOA 4EC3A 1ZR6A 4OALA 4PVKA 4PVJA 5G5GB 1FFUC 5HQXA 3JS8A 5L6FA 2Q4WA 2VFTA 2NQWA 1QLTA 2EXRA 5FXFA 1SB3B 1RM6B 2W54A 2OAIA 2R2ZA 2VFRA 1W1KA 4O95A 4PWBA 5K8EA 2AXRA 4ZOHB 1W1RA 1W1JA 2Y3SA 3S1DA 2VFSA 1E8FA
chains in the Genus database with same CATH topology
5AE2A 4ML8A 4XLOA 4PZFA 3HSUA 2Y08A 2VFUA 1N5WC 4JAYA 2BVGA 1ZXIC 5FXPA 1WVFA 1FO4A 5L6GA 3LAEA 1N63C 1N62C 1UXYA 1N61C 2P4PA 3PM9A 3NVWB 2R8DA 4DNSA 3TSJA 2BVHA 3BW7A 2P3HA 2Q85A 1WVEA 3I99A 1MBTA 3W8ZA 1HSKA 3DEDA 3NVVB 3ETRB 1N5XA 4BCAA 3AN1A 4PWCA 4PYTA 2P13A 1FIQB 3NVYB 3KJMA 1I19A 2BVFA 3S1EA 3VTEA 2Y3RA 3POPA 1VAOA 2W55A 3D2DA 3PQBA 5AE1A 2E3TA 3NRZB 2GQUA 1E8HA 1VDVA 5HHZA 2PLIA 2QPMA 4PVEA 3D2JA 2YVSA 4BC9A 3W8WA 1JROA 3NVZB 1AHUA 2GQTA 3B9JB 2Y4GA 3GSYA 1F0XA 1DIQA 2UUVA 5I1VA 3SR6B 2RK5A 5FXDA 1W1SA 1N60C 5D79A 1FFVC 1T3QC 1W1MA 1QLUA 2O3GA 1WYGA 5FXEA 2QKNA 3HRDC 3DQ0A 4PVHA 1JRPA 1AHZA 2IPIA 2W3SA 5G5HB 2VFVA 1DIIA 1W1LA 2UUUA 5AE3A 3AMZA 2W3RA 3FW8A 5I1WA 1E0YA 4BBYA 3RJAA 3NS1B 3S1FA 3TSHA 3FW9A 1MBBA 4BC7A 4JB1A 5ADZA 5HMRA 3D2HA 4UD8A 1AHVA 3AM9A 3S1CA 5AWVA 3RJ8A 1V97A 2PLSA 3FWAA 1W1QA 2WDWA 1W1OA 3EUB3 1DZNA 3C0PA 3FW7A 4HG0A 2I0KA 3W8XA 4MLAA 3TX1A 2MBRA 3LLBA 1E8GA 2VAOA 4EC3A 1ZR6A 4OALA 4PVKA 4PVJA 5G5GB 1FFUC 5HQXA 3JS8A 5L6FA 2Q4WA 2VFTA 2NQWA 1QLTA 2EXRA 5FXFA 1SB3B 1RM6B 2W54A 2OAIA 2R2ZA 2VFRA 1W1KA 4O95A 4PWBA 5K8EA 2AXRA 4ZOHB 1W1RA 1W1JA 2Y3SA 3S1DA 2VFSA 1E8FA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5AE2 A;  4ML8 A;  4XLO A;  4PZF A;  3HSU A;  2Y08 A;  2VFU A;  1N5W C;  4JAY A;  2BVG A;  1ZXI C;  5FXP A;  1WVF A;  1FO4 A;  5L6G A;  1N63 C;  1N62 C;  1UXY A;  1N61 C;  3PM9 A;  4DNS A;  3TSJ A;  2BVH A;  3BW7 A;  2Q85 A;  1WVE A;  3I99 A;  1MBT A;  3W8Z A;  1HSK A;  3ETR B;  1N5X A;  4BCA A;  3AN1 A;  4PWC A;  4PYT A;  1FIQ B;  3KJM A;  1I19 A;  2BVF A;  3S1E A;  3VTE A;  2Y3R A;  3POP A;  1VAO A;  2W55 A;  3D2D A;  3PQB A;  5AE1 A;  2E3T A;  3NRZ B;  2GQU A;  1E8H A;  1VDV A;  5HHZ A;  2QPM A;  4PVE A;  3D2J A;  4BC9 A;  3W8W A;  1JRO A;  3NVZ B;  1AHU A;  2GQT A;  3B9J B;  2Y4G A;  3GSY A;  1F0X A;  1DIQ A;  5I1V A;  3SR6 B;  5FXD A;  1W1S A;  1N60 C;  5D79 A;  1FFV C;  1T3Q C;  1W1M A;  1QLU A;  1WYG A;  5FXE A;  2QKN A;  3DQ0 A;  4PVH A;  1AHZ A;  2IPI A;  2W3S A;  2VFV A;  1DII A;  1W1L A;  5AE3 A;  3AMZ A;  2W3R A;  3FW8 A;  5I1W A;  1E0Y A;  4BBY A;  3RJA A;  3NS1 B;  3S1F A;  3TSH A;  3FW9 A;  1MBB A;  4BC7 A;  4JB1 A;  5ADZ A;  5HMR A;  3D2H A;  4UD8 A;  1AHV A;  3AM9 A;  3S1C A;  5AWV A;  3RJ8 A;  1V97 A;  3FWA A;  1W1Q A;  2WDW A;  1W1O A;  3EUB 3;  1DZN A;  3C0P A;  3FW7 A;  2I0K A;  3W8X A;  4MLA A;  3TX1 A;  2MBR A;  1E8G A;  2VAO A;  4EC3 A;  1ZR6 A;  4OAL A;  4PVK A;  4PVJ A;  1FFU C;  5HQX A;  3JS8 A;  5L6F A;  2Q4W A;  2VFT A;  1QLT A;  2EXR A;  5FXF A;  2W54 A;  2VFR A;  1W1K A;  4O95 A;  4PWB A;  5K8E A;  2AXR A;  4ZOH B;  1W1R A;  1W1J A;  2Y3S A;  3S1D A;  2VFS A;  1E8F A; 
#chains in the Genus database with same CATH topology
 3EJB B;  5AE2 A;  4ML8 A;  4XLO A;  4PZF A;  3HSU A;  2Y08 A;  2VFU A;  1N5W C;  4JAY A;  2BVG A;  1ZXI C;  3EJD B;  5FXP A;  1WVF A;  1FO4 A;  5L6G A;  3LAE A;  1N63 C;  1N62 C;  1UXY A;  1N61 C;  2P4P A;  3PM9 A;  3NVW B;  2R8D A;  4DNS A;  3TSJ A;  2BVH A;  3BW7 A;  3EJE B;  2P3H A;  2Q85 A;  1WVE A;  3I99 A;  1MBT A;  3NVV B;  1HSK A;  3W8Z A;  3DED A;  3ETR B;  1N5X A;  4BCA A;  3AN1 A;  4PWC A;  4PYT A;  2P13 A;  1FIQ B;  3NVY B;  3KJM A;  1I19 A;  2BVF A;  3S1E A;  3VTE A;  2Y3R A;  3POP A;  1VAO A;  2W55 A;  3D2D A;  3PQB A;  5AE1 A;  2E3T A;  3NRZ B;  2GQU A;  1E8H A;  1VDV A;  5HHZ A;  2PLI A;  2QPM A;  4PVE A;  3D2J A;  2YVS A;  4BC9 A;  3W8W A;  1JRO A;  3NVZ B;  1AHU A;  2GQT A;  3B9J B;  2Y4G A;  3GSY A;  1F0X A;  1DIQ A;  2UUV A;  5I1V A;  3SR6 B;  2RK5 A;  5FXD A;  1W1S A;  1N60 C;  5D79 A;  1FFV C;  1T3Q C;  1W1M A;  1QLU A;  2O3G A;  1WYG A;  5FXE A;  2QKN A;  3HRD C;  3DQ0 A;  4PVH A;  1JRP A;  1AHZ A;  2IPI A;  2W3S A;  5G5H B;  2VFV A;  1DII A;  1W1L A;  2UUU A;  5AE3 A;  3AMZ A;  2W3R A;  3FW8 A;  5I1W A;  1E0Y A;  4BBY A;  3RJA A;  3NS1 B;  3S1F A;  3TSH A;  3FW9 A;  1MBB A;  4BC7 A;  4JB1 A;  5ADZ A;  5HMR A;  3D2H A;  4UD8 A;  1AHV A;  3AM9 A;  3S1C A;  5AWV A;  3RJ8 A;  1V97 A;  2PLS A;  3FWA A;  1W1Q A;  2WDW A;  1W1O A;  3EUB 3;  1DZN A;  3C0P A;  3FW7 A;  4HG0 A;  2I0K A;  3W8X A;  4MLA A;  3TX1 A;  2MBR A;  3LLB A;  1E8G A;  2VAO A;  4EC3 A;  1ZR6 A;  4OAL A;  4PVK A;  4PVJ A;  5G5G B;  1FFU C;  5HQX A;  3JS8 A;  5L6F A;  2Q4W A;  2VFT A;  2NQW A;  1QLT A;  2EXR A;  5FXF A;  1SB3 B;  1RM6 B;  2W54 A;  2OAI A;  2R2Z A;  2VFR A;  1W1K A;  4O95 A;  4PWB A;  5K8E A;  2AXR A;  4ZOH B;  1W1R A;  1W1J A;  2Y3S A;  3S1D A;  2VFS A;  1E8F A; 
#chains in the Genus database with same CATH homology
 5AE2 A;  4ML8 A;  4XLO A;  4PZF A;  3HSU A;  2Y08 A;  2VFU A;  1N5W C;  4JAY A;  2BVG A;  1ZXI C;  5FXP A;  1WVF A;  1FO4 A;  5L6G A;  3LAE A;  1N63 C;  1N62 C;  1UXY A;  1N61 C;  2P4P A;  3PM9 A;  3NVW B;  2R8D A;  4DNS A;  3TSJ A;  2BVH A;  3BW7 A;  2P3H A;  2Q85 A;  1WVE A;  3I99 A;  1MBT A;  3W8Z A;  1HSK A;  3DED A;  3NVV B;  3ETR B;  1N5X A;  4BCA A;  3AN1 A;  4PWC A;  4PYT A;  2P13 A;  1FIQ B;  3NVY B;  3KJM A;  1I19 A;  2BVF A;  3S1E A;  3VTE A;  2Y3R A;  3POP A;  1VAO A;  2W55 A;  3D2D A;  3PQB A;  5AE1 A;  2E3T A;  3NRZ B;  2GQU A;  1E8H A;  1VDV A;  5HHZ A;  2PLI A;  2QPM A;  4PVE A;  3D2J A;  2YVS A;  4BC9 A;  3W8W A;  1JRO A;  3NVZ B;  1AHU A;  2GQT A;  3B9J B;  2Y4G A;  3GSY A;  1F0X A;  1DIQ A;  2UUV A;  5I1V A;  3SR6 B;  2RK5 A;  5FXD A;  1W1S A;  1N60 C;  5D79 A;  1FFV C;  1T3Q C;  1W1M A;  1QLU A;  2O3G A;  1WYG A;  5FXE A;  2QKN A;  3HRD C;  3DQ0 A;  4PVH A;  1JRP A;  1AHZ A;  2IPI A;  2W3S A;  5G5H B;  2VFV A;  1DII A;  1W1L A;  2UUU A;  5AE3 A;  3AMZ A;  2W3R A;  3FW8 A;  5I1W A;  1E0Y A;  4BBY A;  3RJA A;  3NS1 B;  3S1F A;  3TSH A;  3FW9 A;  1MBB A;  4BC7 A;  4JB1 A;  5ADZ A;  5HMR A;  3D2H A;  4UD8 A;  1AHV A;  3AM9 A;  3S1C A;  5AWV A;  3RJ8 A;  1V97 A;  2PLS A;  3FWA A;  1W1Q A;  2WDW A;  1W1O A;  3EUB 3;  1DZN A;  3C0P A;  3FW7 A;  4HG0 A;  2I0K A;  3W8X A;  4MLA A;  3TX1 A;  2MBR A;  3LLB A;  1E8G A;  2VAO A;  4EC3 A;  1ZR6 A;  4OAL A;  4PVK A;  4PVJ A;  5G5G B;  1FFU C;  5HQX A;  3JS8 A;  5L6F A;  2Q4W A;  2VFT A;  2NQW A;  1QLT A;  2EXR A;  5FXF A;  1SB3 B;  1RM6 B;  2W54 A;  2OAI A;  2R2Z A;  2VFR A;  1W1K A;  4O95 A;  4PWB A;  5K8E A;  2AXR A;  4ZOH B;  1W1R A;  1W1J A;  2Y3S A;  3S1D A;  2VFS A;  1E8F A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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