3VTEA

Crystal structure of tetrahydrocannabinolic acid synthase from cannabis sativa
Total Genus 159
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
159
sequence length
518
structure length
502
Chain Sequence
ANPRENFLKCFSKHIPNPKLVYTQHDQLYMSILNSTIQNLRFISDTTPKPLVIVTPSNNSHIQATILCSKKVGLQIRTRSGGHDAEGMSYISQVPFVVVDLRNMHSIKIDVHSQTAWVEAGATLGEVYYWINEKNENLSFPGGYCPTVGVGGHFSGGGYGALMRNYGLAADNIIDAHLVNVDGKVLDRKSMGEDLFWAIRGGGGENFGIIAAWKIKLVAVPSKSTIFSVKKNMEIHGLVKLFNKWQNIAYKYDKDLVLMTHFITKNITTTVHGYFSSIFHGGVDSLVDLMNKSFPELGIKKTDCKEFSWIDTTIFYSGVVNFKKEILLDRSAGKKTAFSIKLDYVKKPIPETAMVKILEKLYEEDVGAGMYVLYPYGGIMEEISESAIPFPHRAGIMYELWYTASWEKQEDNEKHINWVRSVYNFTTPYVSQNPRLAYLNYRDLDLGKTNHASPNNYTQARIWGEKYFGKNFNRLVKVKTKVDPNNFFRNEQSIPPLPPHHH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Tetrahydrocannabinolic acid synthase
publication title Structure and function of 1-tetrahydrocannabinolic acid (THCA) synthase, the enzyme controlling the psychoactivity of Cannabis sativa
pubmed doi rcsb
source organism Cannabis sativa
molecule tags Oxidoreductase
total genus 159
structure length 502
sequence length 518
ec nomenclature ec 1.21.3.7: Tetrahydrocannabinolic acid synthase.
pdb deposition date 2012-05-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01565 FAD_binding_4 FAD binding domain
A PF08031 BBE Berberine and berberine like
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.43.10 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2 3vteA01
3.30.465.50 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 3vteA02
3.40.462.20 Alpha Beta 3-Layer(aba) Sandwich Vanillyl-alcohol Oxidase; Chain A, domain 3 Vanillyl-alcohol Oxidase; Chain A, domain 3 3vteA03
1N63C 2AXRA 4XLOA 5FXFA 4JB1A 3PQBA 1E0YA 3GSYA 1DIQA 3S1CA 3VTEA 1E8FA 2VAOA 4PWBA 3S1DA 2Y3RA 3NS1B 3SR6B 3NRZB 3W8XA 1MBBA 2VFVA 1N5WC 5AWVA 1ZXIC 3BW7A 2GQUA 4PYTA 1W1JA 4MLAA 3W8ZA 1MBTA 2QKNA 4ZOHB 4BC9A 5L6FA 5ADZA 2VFSA 1WVEA 5HHZA 1N5XA 3TSHA 5HQXA 2Y4GA 1W1QA 4PZFA 4JAYA 5K8EA 3I99A 1E8HA 2E3TA 2W3RA 1UXYA 4PVKA 3TX1A 1W1SA 1FO4A 3JS8A 1W1RA 2QPMA 3AN1A 3FW7A 4BCAA 4DNSA 3AM9A 3NVZB 4PVEA 1FIQB 2VFTA 3AMZA 1W1KA 3PM9A 3D2DA 1I19A 2Q4WA 4UD8A 2Y08A 1E8GA 3FWAA 3W8WA 2IPIA 2EXRA 1WVFA 3B9JB 5FXDA 3RJ8A 1AHZA 4O95A 1AHVA 1FFVC 2VFUA 5I1WA 1N61C 2W3SA 5AE3A 2GQTA 4BBYA 4PVJA 1QLTA 2W54A 5FXEA 4OALA 4EC3A 1VDVA 3FW8A 1W1OA 5AE2A 1AHUA 3DQ0A 4PWCA 1F0XA 3D2JA 3RJAA 1DIIA 1QLUA 3HSUA 1W1MA 2MBRA 1FFUC 2I0KA 5AE1A 5HMRA 1ZR6A 1N60C 1V97A 1T3QC 2BVFA 3KJMA 5D79A 5FXPA 3S1EA 2WDWA 2VFRA 1JROA 3S1FA 4ML8A 3FW9A 2BVHA 3D2HA 5I1VA 3TSJA 2W55A 1HSKA 2BVGA 3C0PA 4BC7A 5L6GA 2Y3SA 2Q85A 1VAOA 3POPA 3ETRB 3EUB3 1WYGA 1N62C 4PVHA 1W1LA 1DZNA
chains in the Genus database with same CATH superfamily
1N63C 2AXRA 4XLOA 5FXFA 4JB1A 2YVSA 1E0YA 3GSYA 1DIQA 3PQBA 3S1CA 3VTEA 1SB3B 1E8FA 2VAOA 2PLSA 4PWBA 2PLIA 3S1DA 2Y3RA 3NS1B 3SR6B 3NRZB 3W8XA 1MBBA 2VFVA 2O3GA 1N5WC 5AWVA 1ZXIC 3BW7A 2GQUA 4PYTA 1JRPA 1W1JA 2P4PA 4MLAA 3W8ZA 1MBTA 2QKNA 4ZOHB 4BC9A 5L6FA 5ADZA 2VFSA 1WVEA 5HHZA 2UUVA 1N5XA 3TSHA 5HQXA 2Y4GA 1W1QA 4PZFA 4JAYA 5K8EA 3I99A 1E8HA 2E3TA 2W3RA 1UXYA 4PVKA 3TX1A 1RM6B 3NVVB 1W1SA 3EJBB 1FO4A 3LLBA 3JS8A 1W1RA 3EJEB 2QPMA 3AN1A 3FW7A 4BCAA 4DNSA 2P3HA 3AM9A 3NVZB 5G5GB 4PVEA 1FIQB 4HG0A 2VFTA 3AMZA 1W1KA 3PM9A 3D2DA 1I19A 2Q4WA 3DEDA 4UD8A 2Y08A 1E8GA 3FWAA 3W8WA 2IPIA 2EXRA 2R8DA 1WVFA 3B9JB 5FXDA 3EJDB 3RJ8A 1AHZA 3LAEA 4O95A 1AHVA 1FFVC 2VFUA 5I1WA 1N61C 3HRDC 2W3SA 5AE3A 2GQTA 4BBYA 4PVJA 1QLTA 2W54A 3NVWB 5FXEA 4OALA 4EC3A 1VDVA 3FW8A 1W1OA 5AE2A 1AHUA 3DQ0A 4PWCA 2NQWA 2OAIA 1F0XA 3D2JA 3RJAA 1DIIA 1QLUA 3HSUA 1W1MA 2MBRA 1FFUC 2I0KA 5AE1A 5HMRA 1ZR6A 1N60C 1V97A 1T3QC 2BVFA 3KJMA 5D79A 5FXPA 3S1EA 2P13A 2RK5A 2WDWA 5G5HB 2VFRA 1JROA 3S1FA 4ML8A 3FW9A 2BVHA 3D2HA 2UUUA 5I1VA 3TSJA 2W55A 1HSKA 2BVGA 3C0PA 4BC7A 5L6GA 2Y3SA 2Q85A 3NVYB 1VAOA 2R2ZA 3POPA 3ETRB 3EUB3 1WYGA 1N62C 4PVHA 1W1LA 1DZNA
chains in the Genus database with same CATH topology
1N63C 2AXRA 4XLOA 5FXFA 4JB1A 2YVSA 1E0YA 3GSYA 1DIQA 3PQBA 3S1CA 3VTEA 1SB3B 1E8FA 2VAOA 2PLSA 4PWBA 2PLIA 3S1DA 2Y3RA 3NS1B 3SR6B 3NRZB 3W8XA 1MBBA 2VFVA 2O3GA 1N5WC 5AWVA 1ZXIC 3BW7A 2GQUA 4PYTA 1JRPA 1W1JA 2P4PA 4MLAA 3W8ZA 1MBTA 2QKNA 4ZOHB 4BC9A 5L6FA 5ADZA 2VFSA 1WVEA 5HHZA 2UUVA 1N5XA 3TSHA 5HQXA 2Y4GA 1W1QA 4PZFA 4JAYA 5K8EA 3I99A 1E8HA 2E3TA 2W3RA 1UXYA 4PVKA 3TX1A 1RM6B 3NVVB 1W1SA 1FO4A 3LLBA 3JS8A 1W1RA 2QPMA 3AN1A 3FW7A 4BCAA 4DNSA 2P3HA 3AM9A 3NVZB 5G5GB 4PVEA 1FIQB 4HG0A 2VFTA 3AMZA 1W1KA 3PM9A 3D2DA 1I19A 2Q4WA 3DEDA 4UD8A 2Y08A 1E8GA 3FWAA 3W8WA 2IPIA 2EXRA 2R8DA 1WVFA 3B9JB 5FXDA 3RJ8A 1AHZA 3LAEA 4O95A 1AHVA 1FFVC 2VFUA 5I1WA 1N61C 3HRDC 2W3SA 5AE3A 2GQTA 4BBYA 4PVJA 1QLTA 2W54A 5FXEA 3NVWB 4OALA 4EC3A 1VDVA 3FW8A 1W1OA 5AE2A 1AHUA 3DQ0A 4PWCA 2NQWA 2OAIA 1F0XA 3D2JA 3RJAA 1DIIA 1QLUA 3HSUA 1W1MA 2MBRA 1FFUC 2I0KA 5AE1A 5HMRA 1ZR6A 1N60C 1V97A 1T3QC 2BVFA 3KJMA 5D79A 5FXPA 3S1EA 2P13A 2RK5A 2WDWA 5G5HB 2VFRA 1JROA 3S1FA 4ML8A 3FW9A 2BVHA 3D2HA 2UUUA 5I1VA 3TSJA 2W55A 1HSKA 2BVGA 3C0PA 4BC7A 5L6GA 2Y3SA 2Q85A 3NVYB 1VAOA 2R2ZA 3POPA 3ETRB 3EUB3 1WYGA 1N62C 4PVHA 1W1LA 1DZNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1N63 C;  2AXR A;  4XLO A;  5FXF A;  4JB1 A;  3PQB A;  1E0Y A;  3GSY A;  1DIQ A;  3S1C A;  3VTE A;  1E8F A;  2VAO A;  4PWB A;  3S1D A;  2Y3R A;  3NS1 B;  3SR6 B;  3NRZ B;  3W8X A;  1MBB A;  2VFV A;  1N5W C;  5AWV A;  1ZXI C;  3BW7 A;  2GQU A;  4PYT A;  1W1J A;  4MLA A;  3W8Z A;  1MBT A;  2QKN A;  4ZOH B;  4BC9 A;  5L6F A;  5ADZ A;  2VFS A;  1WVE A;  5HHZ A;  1N5X A;  3TSH A;  5HQX A;  2Y4G A;  1W1Q A;  4PZF A;  4JAY A;  5K8E A;  3I99 A;  1E8H A;  2E3T A;  2W3R A;  1UXY A;  4PVK A;  3TX1 A;  1W1S A;  1FO4 A;  3JS8 A;  1W1R A;  2QPM A;  3AN1 A;  3FW7 A;  4BCA A;  4DNS A;  3AM9 A;  3NVZ B;  4PVE A;  1FIQ B;  2VFT A;  3AMZ A;  1W1K A;  3PM9 A;  3D2D A;  1I19 A;  2Q4W A;  4UD8 A;  2Y08 A;  1E8G A;  3FWA A;  3W8W A;  2IPI A;  2EXR A;  1WVF A;  3B9J B;  5FXD A;  3RJ8 A;  1AHZ A;  4O95 A;  1AHV A;  1FFV C;  2VFU A;  5I1W A;  1N61 C;  2W3S A;  5AE3 A;  2GQT A;  4BBY A;  4PVJ A;  1QLT A;  2W54 A;  5FXE A;  4OAL A;  4EC3 A;  1VDV A;  3FW8 A;  1W1O A;  5AE2 A;  1AHU A;  3DQ0 A;  4PWC A;  1F0X A;  3D2J A;  3RJA A;  1DII A;  1QLU A;  3HSU A;  1W1M A;  2MBR A;  1FFU C;  2I0K A;  5AE1 A;  5HMR A;  1ZR6 A;  1N60 C;  1V97 A;  1T3Q C;  2BVF A;  3KJM A;  5D79 A;  5FXP A;  3S1E A;  2WDW A;  2VFR A;  1JRO A;  3S1F A;  4ML8 A;  3FW9 A;  2BVH A;  3D2H A;  5I1V A;  3TSJ A;  2W55 A;  1HSK A;  2BVG A;  3C0P A;  4BC7 A;  5L6G A;  2Y3S A;  2Q85 A;  1VAO A;  3POP A;  3ETR B;  3EUB 3;  1WYG A;  1N62 C;  4PVH A;  1W1L A;  1DZN A; 
#chains in the Genus database with same CATH topology
 1N63 C;  2AXR A;  4XLO A;  5FXF A;  4JB1 A;  2YVS A;  1E0Y A;  3GSY A;  1DIQ A;  3PQB A;  3S1C A;  3VTE A;  1SB3 B;  1E8F A;  2VAO A;  2PLS A;  4PWB A;  2PLI A;  3S1D A;  2Y3R A;  3NS1 B;  3SR6 B;  3NRZ B;  3W8X A;  1MBB A;  2VFV A;  2O3G A;  1N5W C;  5AWV A;  1ZXI C;  3BW7 A;  2GQU A;  4PYT A;  1JRP A;  1W1J A;  2P4P A;  4MLA A;  3W8Z A;  1MBT A;  2QKN A;  4ZOH B;  4BC9 A;  5L6F A;  5ADZ A;  2VFS A;  1WVE A;  5HHZ A;  2UUV A;  1N5X A;  3TSH A;  5HQX A;  2Y4G A;  1W1Q A;  4PZF A;  4JAY A;  5K8E A;  3I99 A;  1E8H A;  2E3T A;  2W3R A;  1UXY A;  4PVK A;  3TX1 A;  1RM6 B;  3NVV B;  1W1S A;  3EJB B;  1FO4 A;  3LLB A;  3JS8 A;  1W1R A;  3EJE B;  2QPM A;  3AN1 A;  3FW7 A;  4BCA A;  4DNS A;  2P3H A;  3AM9 A;  3NVZ B;  5G5G B;  4PVE A;  1FIQ B;  4HG0 A;  2VFT A;  3AMZ A;  1W1K A;  3PM9 A;  3D2D A;  1I19 A;  2Q4W A;  3DED A;  4UD8 A;  2Y08 A;  1E8G A;  3FWA A;  3W8W A;  2IPI A;  2EXR A;  2R8D A;  1WVF A;  3B9J B;  5FXD A;  3EJD B;  3RJ8 A;  1AHZ A;  3LAE A;  4O95 A;  1AHV A;  1FFV C;  2VFU A;  5I1W A;  1N61 C;  3HRD C;  2W3S A;  5AE3 A;  2GQT A;  4BBY A;  4PVJ A;  1QLT A;  2W54 A;  3NVW B;  5FXE A;  4OAL A;  4EC3 A;  1VDV A;  3FW8 A;  1W1O A;  5AE2 A;  1AHU A;  3DQ0 A;  4PWC A;  2NQW A;  2OAI A;  1F0X A;  3D2J A;  3RJA A;  1DII A;  1QLU A;  3HSU A;  1W1M A;  2MBR A;  1FFU C;  2I0K A;  5AE1 A;  5HMR A;  1ZR6 A;  1N60 C;  1V97 A;  1T3Q C;  2BVF A;  3KJM A;  5D79 A;  5FXP A;  3S1E A;  2P13 A;  2RK5 A;  2WDW A;  5G5H B;  2VFR A;  1JRO A;  3S1F A;  4ML8 A;  3FW9 A;  2BVH A;  3D2H A;  2UUU A;  5I1V A;  3TSJ A;  2W55 A;  1HSK A;  2BVG A;  3C0P A;  4BC7 A;  5L6G A;  2Y3S A;  2Q85 A;  3NVY B;  1VAO A;  2R2Z A;  3POP A;  3ETR B;  3EUB 3;  1WYG A;  1N62 C;  4PVH A;  1W1L A;  1DZN A; 
#chains in the Genus database with same CATH homology
 1N63 C;  2AXR A;  4XLO A;  5FXF A;  4JB1 A;  2YVS A;  1E0Y A;  3GSY A;  1DIQ A;  3PQB A;  3S1C A;  3VTE A;  1SB3 B;  1E8F A;  2VAO A;  2PLS A;  4PWB A;  2PLI A;  3S1D A;  2Y3R A;  3NS1 B;  3SR6 B;  3NRZ B;  3W8X A;  1MBB A;  2VFV A;  2O3G A;  1N5W C;  5AWV A;  1ZXI C;  3BW7 A;  2GQU A;  4PYT A;  1JRP A;  1W1J A;  2P4P A;  4MLA A;  3W8Z A;  1MBT A;  2QKN A;  4ZOH B;  4BC9 A;  5L6F A;  5ADZ A;  2VFS A;  1WVE A;  5HHZ A;  2UUV A;  1N5X A;  3TSH A;  5HQX A;  2Y4G A;  1W1Q A;  4PZF A;  4JAY A;  5K8E A;  3I99 A;  1E8H A;  2E3T A;  2W3R A;  1UXY A;  4PVK A;  3TX1 A;  1RM6 B;  3NVV B;  1W1S A;  1FO4 A;  3LLB A;  3JS8 A;  1W1R A;  2QPM A;  3AN1 A;  3FW7 A;  4BCA A;  4DNS A;  2P3H A;  3AM9 A;  3NVZ B;  5G5G B;  4PVE A;  1FIQ B;  4HG0 A;  2VFT A;  3AMZ A;  1W1K A;  3PM9 A;  3D2D A;  1I19 A;  2Q4W A;  3DED A;  4UD8 A;  2Y08 A;  1E8G A;  3FWA A;  3W8W A;  2IPI A;  2EXR A;  2R8D A;  1WVF A;  3B9J B;  5FXD A;  3RJ8 A;  1AHZ A;  3LAE A;  4O95 A;  1AHV A;  1FFV C;  2VFU A;  5I1W A;  1N61 C;  3HRD C;  2W3S A;  5AE3 A;  2GQT A;  4BBY A;  4PVJ A;  1QLT A;  2W54 A;  5FXE A;  3NVW B;  4OAL A;  4EC3 A;  1VDV A;  3FW8 A;  1W1O A;  5AE2 A;  1AHU A;  3DQ0 A;  4PWC A;  2NQW A;  2OAI A;  1F0X A;  3D2J A;  3RJA A;  1DII A;  1QLU A;  3HSU A;  1W1M A;  2MBR A;  1FFU C;  2I0K A;  5AE1 A;  5HMR A;  1ZR6 A;  1N60 C;  1V97 A;  1T3Q C;  2BVF A;  3KJM A;  5D79 A;  5FXP A;  3S1E A;  2P13 A;  2RK5 A;  2WDW A;  5G5H B;  2VFR A;  1JRO A;  3S1F A;  4ML8 A;  3FW9 A;  2BVH A;  3D2H A;  2UUU A;  5I1V A;  3TSJ A;  2W55 A;  1HSK A;  2BVG A;  3C0P A;  4BC7 A;  5L6G A;  2Y3S A;  2Q85 A;  3NVY B;  1VAO A;  2R2Z A;  3POP A;  3ETR B;  3EUB 3;  1WYG A;  1N62 C;  4PVH A;  1W1L A;  1DZN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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