1W1LA

Structure of the octameric flavoenzyme vanillyl-alcohol oxidase: phe454tyr mutant
Total Genus 170
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
170
sequence length
555
structure length
550
Chain Sequence
EFRPLTLPPKLSLSDFNEFIQDIIRIVGSENVEVISVDGSYMKPTHTHDPHHVMDQDYFLASAIVAPRNVADVQSIVGLANKFSFPLWPISIGRNSGYGGAAPRVSGSVVLDMGKNMNRVLEVNVEGAYCVVEPGVTYHDLHNYLEANNLRDKLWLDVPDLGGGSVLGNAVERGVGYTPYGDHWMMHSGMEVVLANGELLRTGMGALPDPKRPETMGLKPEDQPWSKIAHLFPYGFGPYIDGLFSQSNMGIVTKIGIWLMPNPRGYQSYLITLPKDGDLKQAVDIIRPLRLGMALQNVPTIRHILLDAAVLGDKRSYSSRTEPLSDEELDKIAKQLNLGRWNFYGALYGPEPIRRVLWETIKDAFSAIPGVKFYFPEDTPENSVLRVRDKTMQGIPTYDELKWIDWLPNGAHLFFSPIAKVSGEDAMMQYAVTKKRCQEAGLDYIGTFTVGMREMHHIVCIVFNKKDLIQKRKVQWLMRTLIDDCAANGWGEYRTHLAFMDQIMETYNWNNSSFLRFNEVLKNAVDPNGIIAPGKSGVWPSQYSHVTWKL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Laboratory-Evolved Vanillyl-Alcohol Oxidase Produces Natural Vanillin
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Penicillium simplicissimum
molecule keywords VANILLYL-ALCOHOL OXIDASE
total genus 170
structure length 550
sequence length 555
chains with identical sequence B
ec nomenclature ec 1.1.3.38: Vanillyl-alcohol oxidase.
pdb deposition date 2004-06-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01565 FAD_binding_4 FAD binding domain
A PF02913 FAD-oxidase_C FAD linked oxidases, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.45.10 Mainly Alpha Orthogonal Bundle Vanillyl-alcohol Oxidase; Chain A, domain 4 Vanillyl-alcohol Oxidase; Chain A, domain 4 1w1lA04
3.30.43.10 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2 1w1lA01
3.30.465.10 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 1w1lA02
3.40.462.10 Alpha Beta 3-Layer(aba) Sandwich Vanillyl-alcohol Oxidase; Chain A, domain 3 FAD-linked oxidases, C-terminal domain 1w1lA03
3JS8A 3AM9A 4MLAA 5G5GB 1SB3B 2AXRA 5AE1A 2W54A 2YVSA 2GQUA 5HQXA 1W1MA 3VTEA 5AE3A 2O3GA 3ETRB 1W1RA 5FXEA 5FXPA 3W8XA 3TSHA 1W1KA 4PVEA 1W1JA 1N61C 4ZOHB 4EC3A 5FXDA 5ADZA 2BVGA 2R8DA 3S1EA 3DEDA 3NVVB 2EXRA 3LLBA 3D2HA 1W1OA 4PVHA 5HMRA 5D79A 4HG0A 2W3RA 2VFVA 1N63C 4PVKA 2W55A 1W1SA 3NVWB 2NQWA 1AHVA 4PYTA 3FWAA 4BBYA 2PLSA 2I0KA 1ZXIC 1F0XA 3FW8A 1N5WC 3S1DA 4JB1A 2VFUA 1MBTA 1W1LA 4PWCA 3NRZB 3NVYB 2BVHA 2BVFA 3SR6B 1QLUA 1E8GA 5HHZA 2P3HA 3TSJA 1VDVA 5AE2A 2VFSA 1E8HA 3LAEA 3FW7A 2Q4WA 3NVZB 4BCAA 2W3SA 5G5HB 1I19A 3B9JB 2PLIA 2VFTA 1T3QC 4OALA 2P4PA 3PM9A 1DIIA 1N62C 3HRDC 2VFRA 2QPMA 1FO4A 3D2JA 3BW7A 4O95A 1FFUC 1FFVC 3S1FA 2RK5A 1E0YA 1DZNA 4BC9A 3TX1A 3GSYA 2OAIA 1AHZA 3AN1A 4UD8A 3W8ZA 2GQTA 3S1CA 1HSKA 2QKNA 3DQ0A 2MBRA 1N5XA 1VAOA 4PWBA 4PVJA 1WVEA 1WVFA 1V97A 1N60C 3KJMA 3AMZA 1MBBA 4DNSA 3NS1B 4BC7A 1W1QA 1ZR6A 3C0PA 1JROA 1WYGA 2P13A 1QLTA 2E3TA 1UXYA 1AHUA 2Q85A 3I99A 1RM6B 4JAYA 2VAOA 4ML8A 1DIQA 4XLOA 3EUB3 1JRPA 1E8FA 3W8WA 1FIQB 3FW9A 3D2DA 4PZFA 2R2ZA 5FXFA
chains in the Genus database with same CATH superfamily
3JS8A 3AM9A 4MLAA 5G5GB 1SB3B 2AXRA 5AE1A 2W54A 2YVSA 3RJ8A 2GQUA 5HQXA 1W1MA 3VTEA 5AE3A 2O3GA 3ETRB 2Y08A 1W1RA 5FXEA 5FXPA 3W8XA 5I1WA 3TSHA 1W1KA 4PVEA 1W1JA 1N61C 3NVVB 4ZOHB 5FXDA 5ADZA 2BVGA 4EC3A 3S1EA 2R8DA 3DEDA 3POPA 2EXRA 3LLBA 3D2HA 1W1OA 4PVHA 5HMRA 5D79A 4HG0A 2WDWA 2W3RA 2VFVA 1N63C 4PVKA 2W55A 1W1SA 3NVWB 2NQWA 1AHVA 4PYTA 3FWAA 4BBYA 2PLSA 3RJAA 2I0KA 1ZXIC 1F0XA 3FW8A 1N5WC 3S1DA 3EJEB 4JB1A 2VFUA 1MBTA 1W1LA 4PWCA 3NRZB 3NVYB 3PQBA 2BVHA 2BVFA 3SR6B 1QLUA 1E8GA 5HHZA 2P3HA 3TSJA 1VDVA 5AE2A 2VFSA 5L6GA 3EJDB 1E8HA 3LAEA 3FW7A 5K8EA 2Q4WA 3NVZB 4BCAA 2W3SA 5G5HB 1I19A 3B9JB 2PLIA 2VFTA 1T3QC 4OALA 3HSUA 2P4PA 3PM9A 1DIIA 1N62C 3HRDC 2VFRA 2QPMA 1FO4A 3D2JA 3BW7A 4O95A 1FFUC 5AWVA 5L6FA 1FFVC 3S1FA 2RK5A 2UUUA 1E0YA 1DZNA 4BC9A 3TX1A 3GSYA 2OAIA 1AHZA 3AN1A 4UD8A 2Y3SA 3W8ZA 2GQTA 3S1CA 1HSKA 2QKNA 3DQ0A 2MBRA 1N5XA 1VAOA 4PWBA 4PVJA 1WVEA 1WVFA 1V97A 1N60C 3KJMA 3AMZA 1MBBA 4DNSA 3NS1B 4BC7A 1W1QA 1ZR6A 3C0PA 1JROA 2Y3RA 1WYGA 3EJBB 2P13A 1QLTA 2E3TA 1UXYA 2Y4GA 1AHUA 2Q85A 3I99A 2UUVA 1RM6B 4JAYA 2VAOA 4ML8A 1DIQA 4XLOA 3EUB3 5I1VA 1JRPA 1E8FA 3W8WA 1FIQB 3FW9A 3D2DA 4PZFA 2R2ZA 2IPIA 5FXFA
chains in the Genus database with same CATH topology
3JS8A 3AM9A 4MLAA 5G5GB 1SB3B 2AXRA 5AE1A 2W54A 2YVSA 3RJ8A 2GQUA 5HQXA 1W1MA 3VTEA 5AE3A 2O3GA 3ETRB 2Y08A 1W1RA 5FXEA 5FXPA 3W8XA 5I1WA 3TSHA 1W1KA 4PVEA 1W1JA 1N61C 4ZOHB 4EC3A 5FXDA 5ADZA 2BVGA 2R8DA 3S1EA 3DEDA 3NVVB 3POPA 2EXRA 3LLBA 3D2HA 1W1OA 4PVHA 5HMRA 5D79A 4HG0A 2WDWA 2W3RA 2VFVA 1N63C 4PVKA 2W55A 1W1SA 3NVWB 2NQWA 1AHVA 4PYTA 3FWAA 4BBYA 2PLSA 3RJAA 2I0KA 1ZXIC 1F0XA 3FW8A 1N5WC 3S1DA 4JB1A 2VFUA 1MBTA 1W1LA 4PWCA 3NRZB 3NVYB 3PQBA 2BVHA 2BVFA 3SR6B 1QLUA 1E8GA 5HHZA 2P3HA 3TSJA 1VDVA 5AE2A 2VFSA 5L6GA 1E8HA 3LAEA 3FW7A 5K8EA 2Q4WA 3NVZB 4BCAA 2W3SA 5G5HB 1I19A 3B9JB 2PLIA 2VFTA 1T3QC 4OALA 3HSUA 2P4PA 3PM9A 1DIIA 1N62C 3HRDC 2VFRA 2QPMA 1FO4A 3D2JA 3BW7A 4O95A 1FFUC 5AWVA 5L6FA 1FFVC 3S1FA 2RK5A 2UUUA 1E0YA 1DZNA 4BC9A 3TX1A 3GSYA 2OAIA 1AHZA 3AN1A 4UD8A 2Y3SA 3W8ZA 2GQTA 3S1CA 1HSKA 2QKNA 3DQ0A 2MBRA 1N5XA 1VAOA 4PWBA 4PVJA 1WVEA 1WVFA 1V97A 1N60C 3KJMA 3AMZA 1MBBA 4DNSA 3NS1B 4BC7A 1W1QA 1ZR6A 3C0PA 1JROA 2Y3RA 1WYGA 2P13A 1QLTA 2E3TA 1UXYA 2Y4GA 1AHUA 2Q85A 3I99A 2UUVA 1RM6B 4JAYA 2VAOA 4ML8A 1DIQA 4XLOA 3EUB3 5I1VA 1JRPA 1E8FA 3W8WA 1FIQB 3FW9A 3D2DA 4PZFA 2R2ZA 2IPIA 5FXFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3JS8 A;  3AM9 A;  4MLA A;  5G5G B;  1SB3 B;  2AXR A;  5AE1 A;  2W54 A;  2YVS A;  2GQU A;  5HQX A;  1W1M A;  3VTE A;  5AE3 A;  2O3G A;  3ETR B;  1W1R A;  5FXE A;  5FXP A;  3W8X A;  3TSH A;  1W1K A;  4PVE A;  1W1J A;  1N61 C;  4ZOH B;  4EC3 A;  5FXD A;  5ADZ A;  2BVG A;  2R8D A;  3S1E A;  3DED A;  3NVV B;  2EXR A;  3LLB A;  3D2H A;  1W1O A;  4PVH A;  5HMR A;  5D79 A;  4HG0 A;  2W3R A;  2VFV A;  1N63 C;  4PVK A;  2W55 A;  1W1S A;  3NVW B;  2NQW A;  1AHV A;  4PYT A;  3FWA A;  4BBY A;  2PLS A;  2I0K A;  1ZXI C;  1F0X A;  3FW8 A;  1N5W C;  3S1D A;  4JB1 A;  2VFU A;  1MBT A;  1W1L A;  4PWC A;  3NRZ B;  3NVY B;  2BVH A;  2BVF A;  3SR6 B;  1QLU A;  1E8G A;  5HHZ A;  2P3H A;  3TSJ A;  1VDV A;  5AE2 A;  2VFS A;  1E8H A;  3LAE A;  3FW7 A;  2Q4W A;  3NVZ B;  4BCA A;  2W3S A;  5G5H B;  1I19 A;  3B9J B;  2PLI A;  2VFT A;  1T3Q C;  4OAL A;  2P4P A;  3PM9 A;  1DII A;  1N62 C;  3HRD C;  2VFR A;  2QPM A;  1FO4 A;  3D2J A;  3BW7 A;  4O95 A;  1FFU C;  1FFV C;  3S1F A;  2RK5 A;  1E0Y A;  1DZN A;  4BC9 A;  3TX1 A;  3GSY A;  2OAI A;  1AHZ A;  3AN1 A;  4UD8 A;  3W8Z A;  2GQT A;  3S1C A;  1HSK A;  2QKN A;  3DQ0 A;  2MBR A;  1N5X A;  1VAO A;  4PWB A;  4PVJ A;  1WVE A;  1WVF A;  1V97 A;  1N60 C;  3KJM A;  3AMZ A;  1MBB A;  4DNS A;  3NS1 B;  4BC7 A;  1W1Q A;  1ZR6 A;  3C0P A;  1JRO A;  1WYG A;  2P13 A;  1QLT A;  2E3T A;  1UXY A;  1AHU A;  2Q85 A;  3I99 A;  1RM6 B;  4JAY A;  2VAO A;  4ML8 A;  1DIQ A;  4XLO A;  3EUB 3;  1JRP A;  1E8F A;  3W8W A;  1FIQ B;  3FW9 A;  3D2D A;  4PZF A;  2R2Z A;  5FXF A; 
#chains in the Genus database with same CATH topology
 3JS8 A;  3AM9 A;  4MLA A;  5G5G B;  1SB3 B;  2AXR A;  5AE1 A;  2W54 A;  2YVS A;  3RJ8 A;  2GQU A;  5HQX A;  1W1M A;  3VTE A;  5AE3 A;  2O3G A;  3ETR B;  2Y08 A;  1W1R A;  5FXE A;  5FXP A;  3W8X A;  5I1W A;  3TSH A;  1W1K A;  4PVE A;  1W1J A;  1N61 C;  3NVV B;  4ZOH B;  5FXD A;  5ADZ A;  2BVG A;  4EC3 A;  3S1E A;  2R8D A;  3DED A;  3POP A;  2EXR A;  3LLB A;  3D2H A;  1W1O A;  4PVH A;  5HMR A;  5D79 A;  4HG0 A;  2WDW A;  2W3R A;  2VFV A;  1N63 C;  4PVK A;  2W55 A;  1W1S A;  3NVW B;  2NQW A;  1AHV A;  4PYT A;  3FWA A;  4BBY A;  2PLS A;  3RJA A;  2I0K A;  1ZXI C;  1F0X A;  3FW8 A;  1N5W C;  3S1D A;  3EJE B;  4JB1 A;  2VFU A;  1MBT A;  1W1L A;  4PWC A;  3NRZ B;  3NVY B;  3PQB A;  2BVH A;  2BVF A;  3SR6 B;  1QLU A;  1E8G A;  5HHZ A;  2P3H A;  3TSJ A;  1VDV A;  5AE2 A;  2VFS A;  5L6G A;  3EJD B;  1E8H A;  3LAE A;  3FW7 A;  5K8E A;  2Q4W A;  3NVZ B;  4BCA A;  2W3S A;  5G5H B;  1I19 A;  3B9J B;  2PLI A;  2VFT A;  1T3Q C;  4OAL A;  3HSU A;  2P4P A;  3PM9 A;  1DII A;  1N62 C;  3HRD C;  2VFR A;  2QPM A;  1FO4 A;  3D2J A;  3BW7 A;  4O95 A;  1FFU C;  5AWV A;  5L6F A;  1FFV C;  3S1F A;  2RK5 A;  2UUU A;  1E0Y A;  1DZN A;  4BC9 A;  3TX1 A;  3GSY A;  2OAI A;  1AHZ A;  3AN1 A;  4UD8 A;  2Y3S A;  3W8Z A;  2GQT A;  3S1C A;  1HSK A;  2QKN A;  3DQ0 A;  2MBR A;  1N5X A;  1VAO A;  4PWB A;  4PVJ A;  1WVE A;  1WVF A;  1V97 A;  1N60 C;  3KJM A;  3AMZ A;  1MBB A;  4DNS A;  3NS1 B;  4BC7 A;  1W1Q A;  1ZR6 A;  3C0P A;  1JRO A;  2Y3R A;  1WYG A;  3EJB B;  2P13 A;  1QLT A;  2E3T A;  1UXY A;  2Y4G A;  1AHU A;  2Q85 A;  3I99 A;  2UUV A;  1RM6 B;  4JAY A;  2VAO A;  4ML8 A;  1DIQ A;  4XLO A;  3EUB 3;  5I1V A;  1JRP A;  1E8F A;  3W8W A;  1FIQ B;  3FW9 A;  3D2D A;  4PZF A;  2R2Z A;  2IPI A;  5FXF A; 
#chains in the Genus database with same CATH homology
 3JS8 A;  3AM9 A;  4MLA A;  5G5G B;  1SB3 B;  2AXR A;  5AE1 A;  2W54 A;  2YVS A;  3RJ8 A;  2GQU A;  5HQX A;  1W1M A;  3VTE A;  5AE3 A;  2O3G A;  3ETR B;  2Y08 A;  1W1R A;  5FXE A;  5FXP A;  3W8X A;  5I1W A;  3TSH A;  1W1K A;  4PVE A;  1W1J A;  1N61 C;  4ZOH B;  4EC3 A;  5FXD A;  5ADZ A;  2BVG A;  2R8D A;  3S1E A;  3DED A;  3NVV B;  3POP A;  2EXR A;  3LLB A;  3D2H A;  1W1O A;  4PVH A;  5HMR A;  5D79 A;  4HG0 A;  2WDW A;  2W3R A;  2VFV A;  1N63 C;  4PVK A;  2W55 A;  1W1S A;  3NVW B;  2NQW A;  1AHV A;  4PYT A;  3FWA A;  4BBY A;  2PLS A;  3RJA A;  2I0K A;  1ZXI C;  1F0X A;  3FW8 A;  1N5W C;  3S1D A;  4JB1 A;  2VFU A;  1MBT A;  1W1L A;  4PWC A;  3NRZ B;  3NVY B;  3PQB A;  2BVH A;  2BVF A;  3SR6 B;  1QLU A;  1E8G A;  5HHZ A;  2P3H A;  3TSJ A;  1VDV A;  5AE2 A;  2VFS A;  5L6G A;  1E8H A;  3LAE A;  3FW7 A;  5K8E A;  2Q4W A;  3NVZ B;  4BCA A;  2W3S A;  5G5H B;  1I19 A;  3B9J B;  2PLI A;  2VFT A;  1T3Q C;  4OAL A;  3HSU A;  2P4P A;  3PM9 A;  1DII A;  1N62 C;  3HRD C;  2VFR A;  2QPM A;  1FO4 A;  3D2J A;  3BW7 A;  4O95 A;  1FFU C;  5AWV A;  5L6F A;  1FFV C;  3S1F A;  2RK5 A;  2UUU A;  1E0Y A;  1DZN A;  4BC9 A;  3TX1 A;  3GSY A;  2OAI A;  1AHZ A;  3AN1 A;  4UD8 A;  2Y3S A;  3W8Z A;  2GQT A;  3S1C A;  1HSK A;  2QKN A;  3DQ0 A;  2MBR A;  1N5X A;  1VAO A;  4PWB A;  4PVJ A;  1WVE A;  1WVF A;  1V97 A;  1N60 C;  3KJM A;  3AMZ A;  1MBB A;  4DNS A;  3NS1 B;  4BC7 A;  1W1Q A;  1ZR6 A;  3C0P A;  1JRO A;  2Y3R A;  1WYG A;  2P13 A;  1QLT A;  2E3T A;  1UXY A;  2Y4G A;  1AHU A;  2Q85 A;  3I99 A;  2UUV A;  1RM6 B;  4JAY A;  2VAO A;  4ML8 A;  1DIQ A;  4XLO A;  3EUB 3;  5I1V A;  1JRP A;  1E8F A;  3W8W A;  1FIQ B;  3FW9 A;  3D2D A;  4PZF A;  2R2Z A;  2IPI A;  5FXF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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