2Y4GA

Structure of the tirandamycin-bound fad-dependent tirandamycin oxidase taml in p212121 space group
Total Genus 159
50100150200250300350400450020406080100120140160
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
159
sequence length
500
structure length
500
Chain Sequence
MKHIDSVAPGDIRYEDLRRGENLRFVGDPEEIHLVGSAAEIEQVLSRAVRSGKRVAVRSGGHCYEDFVANSDVRVVMDMSRLSAVGFDEERGAFAVEAGATLGAVYKTLFRVWGVTLPGGACPDVGAGGHILGGGYGPLSRMHGSIVDYLHAVEVVVVDASGDARTVIATREPSDPNHDLWWAHTGGGGGNFGVVVRYWLRTAEADVPPEPGRLLPRPPAEVLLNTTVWPWEGLDEAAFARLVRNHGRWFEQNSGPDSPWCDLYSVLALTRSQSGALAMTTQLDATGPDAEKRLETYLAAVSEGVGVQPHSDTRRLPWLHSTRWPGIAGDGDMTGRAKIKAAYARRSFDDRQIGTLYTRLTSTDYDNPAGVVALIAYGGKVNAVPADRTAVAQRDSILKIVYVTTWEDPAQDPVHVRWIRELYRDVYADTGGVPVPGGAADGAYVNYPDVDLADEEWNTSGVPWSELYYKDAYPRLQAVKARWDPRNVFRHALSVRVPPA
50100150200250300350400450400300200100
050100150Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
molecule tags Oxidoreductase
source organism Streptomyces sp. 307-9
publication title Tirandamycin Biosynthesis is Mediated by Co-Dependent Oxidative Enzymes
pubmed doi rcsb
molecule keywords TAML
total genus 159
structure length 500
sequence length 500
chains with identical sequence B
ec nomenclature
pdb deposition date 2011-01-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01565 FAD_binding_4 FAD binding domain
A PF08031 BBE Berberine and berberine like
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.465.40 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 2y4gA01
3.40.462.20 Alpha Beta 3-Layer(aba) Sandwich Vanillyl-alcohol Oxidase; Chain A, domain 3 Vanillyl-alcohol Oxidase; Chain A, domain 3 2y4gA02
2Y3RA 5AWVA 2BVFA 5L6FA 3D2DA 4PZFA 2UUVA 3TSHA 5L6GA 2Y4GA 1ZR6A 3FW8A 2BVGA 3POPA 2IPIA 5I1WA 2Y08A 2UUUA 3D2JA 4PWBA 3FW7A 3RJAA 3GSYA 5K8EA 4PVHA 3RJ8A 5D79A 3FW9A 2Y3SA 4PVJA 3D2HA 4PVKA 5I1VA 2AXRA 4PVEA 4PWCA 3W8XA 3FWAA 4DNSA 3PQBA 4XLOA 2BVHA 3W8ZA 3W8WA 3VTEA 2WDWA 4UD8A 4EC3A 3HSUA 3TSJA
chains in the Genus database with same CATH superfamily
1W1QA 4HG0A 3D2DA 2R8DA 2PLIA 2UUVA 3I99A 3BW7A 1AHUA 1DIQA 5FXDA 4ML8A 1W1MA 2MBRA 1DZNA 2UUUA 1N61C 1AHZA 3FW7A 2E3TA 3DEDA 1E8HA 2Q4WA 1QLTA 3RJ8A 4MLAA 5FXEA 1W1RA 4PVKA 2AXRA 1UXYA 3FWAA 3HRDC 5ADZA 1W1SA 2BVHA 3W8ZA 3NRZB 1F0XA 2W54A 4BBYA 4JB1A 1N62C 4EC3A 3TSJA 1FIQB 4JAYA 1VDVA 3S1CA 2Y3RA 1QLUA 5G5GB 1FFVC 2BVFA 5HMRA 5AE3A 5HHZA 2Y4GA 5L6GA 2BVGA 2W55A 1VAOA 3POPA 2GQTA 3KJMA 1I19A 3JS8A 2EXRA 3RJAA 5G5HB 2OAIA 1AHVA 1FO4A 2QPMA 4PVJA 3C0PA 1W1OA 3NVYB 3S1FA 2P13A 2VFVA 3EUB3 1E8FA 4DNSA 1N5XA 4OALA 2WDWA 1FFUC 4UD8A 3NVZB 1WVFA 1W1JA 3ETRB 3S1EA 2YVSA 1W1KA 2NQWA 3NVVB 5AWVA 5L6FA 2RK5A 2W3SA 1W1LA 4ZOHB 3TSHA 5AE1A 1ZR6A 2R2ZA 4BC7A 5I1WA 2VFSA 3DQ0A 2Y08A 3D2JA 1DIIA 3AN1A 3GSYA 5K8EA 4PVHA 5AE2A 5HQXA 5D79A 2W3RA 3FW9A 3NS1B 1N63C 3D2HA 4PWCA 2O3GA 1E8GA 1RM6B 4XLOA 3W8WA 2P3HA 2GQUA 4PYTA 2VAOA 1WVEA 5FXFA 2I0KA 2Q85A 3S1DA 1JROA 3PM9A 2VFTA 4BCAA 1T3QC 2QKNA 4PZFA 1HSKA 3LAEA 3NVWB 1SB3B 3FW8A 2IPIA 1JRPA 4PWBA 3B9JB 1MBBA 1N5WC 3AMZA 3TX1A 4O95A 1N60C 4BC9A 3LLBA 2Y3SA 1ZXIC 4PVEA 1V97A 2VFUA 5I1VA 3SR6B 3W8XA 1E0YA 1WYGA 5FXPA 2P4PA 3PQBA 3AM9A 2PLSA 1MBTA 3VTEA 3HSUA 2VFRA
chains in the Genus database with same CATH topology
1W1QA 4HG0A 3D2DA 2R8DA 2PLIA 2UUVA 3I99A 3BW7A 1AHUA 1DIQA 5FXDA 4ML8A 1W1MA 2MBRA 1DZNA 2UUUA 1N61C 1AHZA 3FW7A 2E3TA 3DEDA 1E8HA 2Q4WA 1QLTA 3RJ8A 4MLAA 5FXEA 1W1RA 4PVKA 2AXRA 1UXYA 3FWAA 3HRDC 5ADZA 1W1SA 2BVHA 3W8ZA 3NRZB 1F0XA 2W54A 4BBYA 4JB1A 1N62C 4EC3A 3TSJA 1FIQB 4JAYA 1VDVA 3S1CA 2Y3RA 1QLUA 5G5GB 1FFVC 2BVFA 5HMRA 5AE3A 5HHZA 2Y4GA 5L6GA 2BVGA 2W55A 1VAOA 3POPA 2GQTA 3KJMA 1I19A 3JS8A 2EXRA 3RJAA 5G5HB 2OAIA 1AHVA 1FO4A 2QPMA 4PVJA 3C0PA 1W1OA 3NVYB 3S1FA 2P13A 2VFVA 3EUB3 1E8FA 4DNSA 1N5XA 4OALA 2WDWA 1FFUC 4UD8A 3NVZB 1WVFA 1W1JA 3ETRB 3S1EA 2YVSA 1W1KA 2NQWA 3NVVB 5AWVA 5L6FA 2RK5A 2W3SA 1W1LA 4ZOHB 3TSHA 5AE1A 1ZR6A 2R2ZA 4BC7A 5I1WA 2VFSA 3DQ0A 2Y08A 3D2JA 1DIIA 3AN1A 3GSYA 5K8EA 4PVHA 5AE2A 5HQXA 5D79A 2W3RA 3FW9A 3NS1B 1N63C 3D2HA 4PWCA 2O3GA 1E8GA 1RM6B 4XLOA 3W8WA 2P3HA 2GQUA 4PYTA 2VAOA 1WVEA 5FXFA 2I0KA 2Q85A 3S1DA 1JROA 3PM9A 2VFTA 4BCAA 1T3QC 2QKNA 4PZFA 1HSKA 3LAEA 3NVWB 1SB3B 3FW8A 2IPIA 1JRPA 4PWBA 3B9JB 1MBBA 1N5WC 3AMZA 3TX1A 4O95A 1N60C 4BC9A 3LLBA 2Y3SA 1ZXIC 4PVEA 1V97A 2VFUA 5I1VA 3SR6B 3W8XA 1E0YA 1WYGA 5FXPA 2P4PA 3PQBA 3AM9A 2PLSA 1MBTA 3VTEA 3HSUA 2VFRA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2Y3R A;  5AWV A;  2BVF A;  5L6F A;  3D2D A;  4PZF A;  2UUV A;  3TSH A;  5L6G A;  2Y4G A;  1ZR6 A;  3FW8 A;  2BVG A;  3POP A;  2IPI A;  5I1W A;  2Y08 A;  2UUU A;  3D2J A;  4PWB A;  3FW7 A;  3RJA A;  3GSY A;  5K8E A;  4PVH A;  3RJ8 A;  5D79 A;  3FW9 A;  2Y3S A;  4PVJ A;  3D2H A;  4PVK A;  5I1V A;  2AXR A;  4PVE A;  4PWC A;  3W8X A;  3FWA A;  4DNS A;  3PQB A;  4XLO A;  2BVH A;  3W8Z A;  3W8W A;  3VTE A;  2WDW A;  4UD8 A;  4EC3 A;  3HSU A;  3TSJ A; 
#chains in the Genus database with same CATH topology
 1W1Q A;  4HG0 A;  3D2D A;  2R8D A;  2PLI A;  2UUV A;  3I99 A;  3BW7 A;  1AHU A;  1DIQ A;  5FXD A;  4ML8 A;  1W1M A;  2MBR A;  1DZN A;  2UUU A;  1N61 C;  1AHZ A;  3FW7 A;  2E3T A;  3DED A;  1E8H A;  2Q4W A;  1QLT A;  3RJ8 A;  4MLA A;  5FXE A;  1W1R A;  4PVK A;  2AXR A;  1UXY A;  3FWA A;  3HRD C;  5ADZ A;  1W1S A;  2BVH A;  3W8Z A;  3NRZ B;  1F0X A;  2W54 A;  4BBY A;  4JB1 A;  1N62 C;  4EC3 A;  3TSJ A;  1FIQ B;  4JAY A;  1VDV A;  3S1C A;  2Y3R A;  1QLU A;  5G5G B;  1FFV C;  2BVF A;  5HMR A;  5AE3 A;  5HHZ A;  2Y4G A;  5L6G A;  2BVG A;  2W55 A;  1VAO A;  3POP A;  2GQT A;  3KJM A;  1I19 A;  3JS8 A;  2EXR A;  3RJA A;  5G5H B;  2OAI A;  1AHV A;  1FO4 A;  2QPM A;  4PVJ A;  3C0P A;  1W1O A;  3NVY B;  3S1F A;  2P13 A;  2VFV A;  3EUB 3;  1E8F A;  4DNS A;  1N5X A;  4OAL A;  2WDW A;  1FFU C;  4UD8 A;  3NVZ B;  1WVF A;  1W1J A;  3ETR B;  3S1E A;  2YVS A;  1W1K A;  2NQW A;  3NVV B;  5AWV A;  5L6F A;  2RK5 A;  2W3S A;  1W1L A;  4ZOH B;  3TSH A;  5AE1 A;  1ZR6 A;  2R2Z A;  4BC7 A;  5I1W A;  2VFS A;  3DQ0 A;  2Y08 A;  3D2J A;  1DII A;  3AN1 A;  3GSY A;  5K8E A;  4PVH A;  5AE2 A;  5HQX A;  5D79 A;  2W3R A;  3FW9 A;  3NS1 B;  1N63 C;  3D2H A;  4PWC A;  2O3G A;  1E8G A;  1RM6 B;  4XLO A;  3W8W A;  2P3H A;  2GQU A;  4PYT A;  2VAO A;  1WVE A;  5FXF A;  2I0K A;  2Q85 A;  3S1D A;  1JRO A;  3PM9 A;  2VFT A;  4BCA A;  1T3Q C;  2QKN A;  4PZF A;  1HSK A;  3LAE A;  3NVW B;  1SB3 B;  3FW8 A;  2IPI A;  1JRP A;  4PWB A;  3B9J B;  1MBB A;  1N5W C;  3AMZ A;  3TX1 A;  4O95 A;  1N60 C;  4BC9 A;  3LLB A;  2Y3S A;  1ZXI C;  4PVE A;  1V97 A;  2VFU A;  5I1V A;  3SR6 B;  3W8X A;  1E0Y A;  1WYG A;  5FXP A;  2P4P A;  3PQB A;  3AM9 A;  2PLS A;  1MBT A;  3VTE A;  3HSU A;  2VFR A; 
#chains in the Genus database with same CATH homology
 1W1Q A;  4HG0 A;  3D2D A;  2R8D A;  2PLI A;  2UUV A;  3I99 A;  3BW7 A;  1AHU A;  1DIQ A;  5FXD A;  4ML8 A;  1W1M A;  2MBR A;  1DZN A;  2UUU A;  1N61 C;  1AHZ A;  3FW7 A;  2E3T A;  3DED A;  1E8H A;  2Q4W A;  1QLT A;  3RJ8 A;  4MLA A;  5FXE A;  1W1R A;  4PVK A;  2AXR A;  1UXY A;  3FWA A;  3HRD C;  5ADZ A;  1W1S A;  2BVH A;  3W8Z A;  3NRZ B;  1F0X A;  2W54 A;  4BBY A;  4JB1 A;  1N62 C;  4EC3 A;  3TSJ A;  1FIQ B;  4JAY A;  1VDV A;  3S1C A;  2Y3R A;  1QLU A;  5G5G B;  1FFV C;  2BVF A;  5HMR A;  5AE3 A;  5HHZ A;  2Y4G A;  5L6G A;  2BVG A;  2W55 A;  1VAO A;  3POP A;  2GQT A;  3KJM A;  1I19 A;  3JS8 A;  2EXR A;  3RJA A;  5G5H B;  2OAI A;  1AHV A;  1FO4 A;  2QPM A;  4PVJ A;  3C0P A;  1W1O A;  3NVY B;  3S1F A;  2P13 A;  2VFV A;  3EUB 3;  1E8F A;  4DNS A;  1N5X A;  4OAL A;  2WDW A;  1FFU C;  4UD8 A;  3NVZ B;  1WVF A;  1W1J A;  3ETR B;  3S1E A;  2YVS A;  1W1K A;  2NQW A;  3NVV B;  5AWV A;  5L6F A;  2RK5 A;  2W3S A;  1W1L A;  4ZOH B;  3TSH A;  5AE1 A;  1ZR6 A;  2R2Z A;  4BC7 A;  5I1W A;  2VFS A;  3DQ0 A;  2Y08 A;  3D2J A;  1DII A;  3AN1 A;  3GSY A;  5K8E A;  4PVH A;  5AE2 A;  5HQX A;  5D79 A;  2W3R A;  3FW9 A;  3NS1 B;  1N63 C;  3D2H A;  4PWC A;  2O3G A;  1E8G A;  1RM6 B;  4XLO A;  3W8W A;  2P3H A;  2GQU A;  4PYT A;  2VAO A;  1WVE A;  5FXF A;  2I0K A;  2Q85 A;  3S1D A;  1JRO A;  3PM9 A;  2VFT A;  4BCA A;  1T3Q C;  2QKN A;  4PZF A;  1HSK A;  3LAE A;  3NVW B;  1SB3 B;  3FW8 A;  2IPI A;  1JRP A;  4PWB A;  3B9J B;  1MBB A;  1N5W C;  3AMZ A;  3TX1 A;  4O95 A;  1N60 C;  4BC9 A;  3LLB A;  2Y3S A;  1ZXI C;  4PVE A;  1V97 A;  2VFU A;  5I1V A;  3SR6 B;  3W8X A;  1E0Y A;  1WYG A;  5FXP A;  2P4P A;  3PQB A;  3AM9 A;  2PLS A;  1MBT A;  3VTE A;  3HSU A;  2VFR A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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