4PZFA

Berberine bridge enzyme g164a variant, a reticuline dehydrogenase
Total Genus 163
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
163
sequence length
498
structure length
498
Chain Sequence
DLLSCLTFNGVRNHTVFSADSDSDFNRFLHLSIQNPLFQNSLISKPSAIILPGSKEELSNTIRCIRKGSWTIRLRSGGHSYEGLSYTSDTPFILIDLMNLNRVSIDLESETAWVESGSTLGELYYAITESSSKLGFTAAWCPTVGTGGHISGGGFGMMSRKYGLAADNVVDAILIDANGAILDRQAMGEDVFWAIRGGGGGVWGAIYAWKIKLLPVPEKVTVFRVTKNVAIDEATSLLHKWQFVAEELEEDFTLSVLGGADEKQVWLTMLGFHFGLKTVAKSTFDLLFPELGLVEEDYLEMSWGESFAYLAGLETVSQLNNRFLKFDERAFKTKVDLTKEPLPSKAFYGLLERLSKEPNGFIALNGFGGQMSKISSDFTPFPHRSGTRLMVEYIVAWNQSEQKKKTEFLDWLEKVYEFMKPFVSKNPRLGYVNHIDLDLGGIDWGNKTVVNNAIEISRSWGESYFLSNYERLIRAKTLIDPNNVFNHPQSIPPMANFD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Rationally engineered flavin-dependent oxidase reveals steric control of dioxygen reduction.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Eschscholzia californica
molecule keywords Reticuline oxidase
total genus 163
structure length 498
sequence length 498
chains with identical sequence B, C, D
ec nomenclature ec 1.21.3.3: Reticuline oxidase.
pdb deposition date 2014-03-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01565 FAD_binding_4 FAD binding domain
A PF08031 BBE Berberine and berberine like
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.43.10 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2 4pzfA01
3.30.465.50 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 4pzfA02
3.40.462.20 Alpha Beta 3-Layer(aba) Sandwich Vanillyl-alcohol Oxidase; Chain A, domain 3 Vanillyl-alcohol Oxidase; Chain A, domain 3 4pzfA03
3D2DA 4PWBA 2WDWA 2E3TA 2W54A 4DNSA 1AHZA 1I19A 2VFTA 4PVHA 1AHVA 1N5XA 1JROA 5K8EA 1HSKA 5HHZA 1T3QC 2IPIA 3FW8A 2BVGA 1VAOA 4XLOA 1AHUA 1FFVC 1WVFA 3B9JB 5FXPA 1N60C 4OALA 3FW9A 3NS1B 1DIIA 1VDVA 4ZOHB 4PVJA 1N62C 1W1SA 3AMZA 3RJ8A 3PQBA 3SR6B 5L6FA 5FXFA 2W3SA 3KJMA 4PYTA 5AE2A 5HQXA 1DZNA 2BVHA 3AN1A 4O95A 1W1KA 3W8WA 3POPA 3GSYA 5L6GA 4JAYA 1N5WC 1MBBA 3AM9A 1ZXIC 2GQTA 4MLAA 1MBTA 2Q4WA 2AXRA 2VFRA 2W55A 4JB1A 5AWVA 1N61C 2VFVA 2Y3SA 4EC3A 3S1CA 1W1MA 3D2HA 5AE1A 1W1QA 3JS8A 1ZR6A 2QKNA 5D79A 3W8ZA 3S1DA 3TSHA 1QLTA 5ADZA 3FWAA 2W3RA 3W8XA 5I1WA 1E8HA 3S1EA 2Y3RA 2GQUA 2QPMA 3HSUA 1QLUA 3RJAA 3D2JA 2VFSA 4PZFA 2VFUA 3EUB3 2Y08A 4UD8A 1DIQA 1WYGA 1W1OA 5HMRA 1E8GA 1V97A 5AE3A 3BW7A 5I1VA 4BBYA 2MBRA 1W1RA 3DQ0A 4BCAA 3ETRB 2Q85A 3C0PA 4ML8A 2EXRA 4PVEA 1FO4A 1E0YA 3VTEA 1N63C 3NRZB 5FXDA 2BVFA 1E8FA 1FIQB 1UXYA 4PWCA 1FFUC 3TSJA 3PM9A 4PVKA 1F0XA 1W1JA 4BC7A 4BC9A 5FXEA 3FW7A 1WVEA 2VAOA 3TX1A 2I0KA 3I99A 3NVZB 3S1FA 1W1LA 2Y4GA
chains in the Genus database with same CATH superfamily
3D2DA 4PWBA 3LAEA 2WDWA 2E3TA 2W54A 4DNSA 1AHZA 1I19A 2VFTA 4PVHA 2RK5A 1AHVA 1N5XA 1JROA 3EJEB 5K8EA 1HSKA 5HHZA 1T3QC 2IPIA 3FW8A 2BVGA 1VAOA 4XLOA 1AHUA 1FFVC 1WVFA 3EJDB 3B9JB 5FXPA 1N60C 4OALA 3FW9A 3NS1B 1DIIA 1VDVA 4ZOHB 4PVJA 1N62C 1W1SA 3AMZA 3RJ8A 3DEDA 3PQBA 3SR6B 5L6FA 3NVVB 5FXFA 2W3SA 3KJMA 5G5GB 4PYTA 5AE2A 5HQXA 2P4PA 2R8DA 1DZNA 2BVHA 3AN1A 4O95A 1W1KA 3W8WA 2UUVA 3POPA 3GSYA 5L6GA 4JAYA 1N5WC 1MBBA 3AM9A 1ZXIC 2GQTA 4MLAA 1MBTA 2Q4WA 2AXRA 2VFRA 2W55A 1SB3B 4JB1A 5AWVA 3LLBA 1N61C 2VFVA 2O3GA 2Y3SA 4EC3A 3S1CA 1W1MA 3D2HA 5AE1A 1W1QA 2R2ZA 3JS8A 1ZR6A 2QKNA 5D79A 3W8ZA 3S1DA 3TSHA 1QLTA 5ADZA 3FWAA 2W3RA 3W8XA 5I1WA 1E8HA 3S1EA 1JRPA 2Y3RA 2GQUA 2QPMA 2NQWA 3HSUA 1QLUA 1RM6B 3RJAA 2PLSA 3D2JA 2VFSA 2P3HA 4PZFA 2YVSA 2VFUA 3EUB3 2Y08A 4UD8A 2OAIA 1DIQA 2UUUA 1WYGA 1W1OA 5HMRA 2PLIA 4HG0A 1E8GA 1V97A 5AE3A 3BW7A 5G5HB 5I1VA 4BBYA 2MBRA 1W1RA 3DQ0A 4BCAA 3ETRB 2Q85A 3C0PA 4ML8A 2EXRA 4PVEA 1FO4A 1E0YA 3VTEA 1N63C 3NRZB 5FXDA 3NVWB 2BVFA 1E8FA 1FIQB 1UXYA 4PWCA 1FFUC 3TSJA 3PM9A 4PVKA 1F0XA 1W1JA 2P13A 4BC7A 4BC9A 5FXEA 3FW7A 1WVEA 2VAOA 3TX1A 3HRDC 2I0KA 3I99A 3NVYB 3NVZB 3S1FA 1W1LA 2Y4GA 3EJBB
chains in the Genus database with same CATH topology
3D2DA 4PWBA 3LAEA 2WDWA 2E3TA 2W54A 4DNSA 1AHZA 1I19A 2VFTA 4PVHA 2RK5A 1AHVA 1N5XA 1JROA 5K8EA 1HSKA 5HHZA 1T3QC 2IPIA 3FW8A 2BVGA 1VAOA 4XLOA 1AHUA 1FFVC 1WVFA 3B9JB 5FXPA 1N60C 4OALA 3FW9A 3NS1B 1DIIA 1VDVA 4ZOHB 4PVJA 1N62C 1W1SA 3AMZA 3RJ8A 3DEDA 3PQBA 3SR6B 5L6FA 3NVVB 5FXFA 2W3SA 3KJMA 5G5GB 4PYTA 5AE2A 5HQXA 2P4PA 2R8DA 1DZNA 2BVHA 3AN1A 4O95A 1W1KA 3W8WA 2UUVA 3POPA 3GSYA 5L6GA 4JAYA 1N5WC 1MBBA 3AM9A 1ZXIC 2GQTA 4MLAA 1MBTA 2Q4WA 2AXRA 2VFRA 2W55A 1SB3B 4JB1A 5AWVA 3LLBA 1N61C 2VFVA 2O3GA 2Y3SA 4EC3A 3S1CA 1W1MA 3D2HA 5AE1A 1W1QA 2R2ZA 3JS8A 1ZR6A 2QKNA 5D79A 3W8ZA 3S1DA 3TSHA 1QLTA 5ADZA 3FWAA 2W3RA 3W8XA 5I1WA 1E8HA 3S1EA 1JRPA 2Y3RA 2GQUA 2QPMA 2NQWA 3HSUA 1QLUA 1RM6B 3RJAA 2PLSA 3D2JA 2VFSA 2P3HA 4PZFA 2YVSA 2VFUA 3EUB3 2Y08A 4UD8A 2OAIA 1DIQA 2UUUA 1WYGA 1W1OA 5HMRA 2PLIA 4HG0A 1E8GA 1V97A 5AE3A 3BW7A 5G5HB 5I1VA 4BBYA 2MBRA 1W1RA 3DQ0A 4BCAA 3ETRB 2Q85A 3C0PA 4ML8A 2EXRA 4PVEA 1FO4A 1E0YA 3VTEA 1N63C 3NRZB 5FXDA 3NVWB 2BVFA 1E8FA 1FIQB 1UXYA 4PWCA 1FFUC 3TSJA 3PM9A 4PVKA 1F0XA 1W1JA 2P13A 4BC7A 4BC9A 5FXEA 3FW7A 1WVEA 2VAOA 3TX1A 3HRDC 2I0KA 3I99A 3NVZB 3S1FA 3NVYB 1W1LA 2Y4GA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3D2D A;  4PWB A;  2WDW A;  2E3T A;  2W54 A;  4DNS A;  1AHZ A;  1I19 A;  2VFT A;  4PVH A;  1AHV A;  1N5X A;  1JRO A;  5K8E A;  1HSK A;  5HHZ A;  1T3Q C;  2IPI A;  3FW8 A;  2BVG A;  1VAO A;  4XLO A;  1AHU A;  1FFV C;  1WVF A;  3B9J B;  5FXP A;  1N60 C;  4OAL A;  3FW9 A;  3NS1 B;  1DII A;  1VDV A;  4ZOH B;  4PVJ A;  1N62 C;  1W1S A;  3AMZ A;  3RJ8 A;  3PQB A;  3SR6 B;  5L6F A;  5FXF A;  2W3S A;  3KJM A;  4PYT A;  5AE2 A;  5HQX A;  1DZN A;  2BVH A;  3AN1 A;  4O95 A;  1W1K A;  3W8W A;  3POP A;  3GSY A;  5L6G A;  4JAY A;  1N5W C;  1MBB A;  3AM9 A;  1ZXI C;  2GQT A;  4MLA A;  1MBT A;  2Q4W A;  2AXR A;  2VFR A;  2W55 A;  4JB1 A;  5AWV A;  1N61 C;  2VFV A;  2Y3S A;  4EC3 A;  3S1C A;  1W1M A;  3D2H A;  5AE1 A;  1W1Q A;  3JS8 A;  1ZR6 A;  2QKN A;  5D79 A;  3W8Z A;  3S1D A;  3TSH A;  1QLT A;  5ADZ A;  3FWA A;  2W3R A;  3W8X A;  5I1W A;  1E8H A;  3S1E A;  2Y3R A;  2GQU A;  2QPM A;  3HSU A;  1QLU A;  3RJA A;  3D2J A;  2VFS A;  4PZF A;  2VFU A;  3EUB 3;  2Y08 A;  4UD8 A;  1DIQ A;  1WYG A;  1W1O A;  5HMR A;  1E8G A;  1V97 A;  5AE3 A;  3BW7 A;  5I1V A;  4BBY A;  2MBR A;  1W1R A;  3DQ0 A;  4BCA A;  3ETR B;  2Q85 A;  3C0P A;  4ML8 A;  2EXR A;  4PVE A;  1FO4 A;  1E0Y A;  3VTE A;  1N63 C;  3NRZ B;  5FXD A;  2BVF A;  1E8F A;  1FIQ B;  1UXY A;  4PWC A;  1FFU C;  3TSJ A;  3PM9 A;  4PVK A;  1F0X A;  1W1J A;  4BC7 A;  4BC9 A;  5FXE A;  3FW7 A;  1WVE A;  2VAO A;  3TX1 A;  2I0K A;  3I99 A;  3NVZ B;  3S1F A;  1W1L A;  2Y4G A; 
#chains in the Genus database with same CATH topology
 3D2D A;  4PWB A;  3LAE A;  2WDW A;  2E3T A;  2W54 A;  4DNS A;  1AHZ A;  1I19 A;  2VFT A;  4PVH A;  2RK5 A;  1AHV A;  1N5X A;  1JRO A;  3EJE B;  5K8E A;  1HSK A;  5HHZ A;  1T3Q C;  2IPI A;  3FW8 A;  2BVG A;  1VAO A;  4XLO A;  1AHU A;  1FFV C;  1WVF A;  3EJD B;  3B9J B;  5FXP A;  1N60 C;  4OAL A;  3FW9 A;  3NS1 B;  1DII A;  1VDV A;  4ZOH B;  4PVJ A;  1N62 C;  1W1S A;  3AMZ A;  3RJ8 A;  3DED A;  3PQB A;  3SR6 B;  5L6F A;  3NVV B;  5FXF A;  2W3S A;  3KJM A;  5G5G B;  4PYT A;  5AE2 A;  5HQX A;  2P4P A;  2R8D A;  1DZN A;  2BVH A;  3AN1 A;  4O95 A;  1W1K A;  3W8W A;  2UUV A;  3POP A;  3GSY A;  5L6G A;  4JAY A;  1N5W C;  1MBB A;  3AM9 A;  1ZXI C;  2GQT A;  4MLA A;  1MBT A;  2Q4W A;  2AXR A;  2VFR A;  2W55 A;  1SB3 B;  4JB1 A;  5AWV A;  3LLB A;  1N61 C;  2VFV A;  2O3G A;  2Y3S A;  4EC3 A;  3S1C A;  1W1M A;  3D2H A;  5AE1 A;  1W1Q A;  2R2Z A;  3JS8 A;  1ZR6 A;  2QKN A;  5D79 A;  3W8Z A;  3S1D A;  3TSH A;  1QLT A;  5ADZ A;  3FWA A;  2W3R A;  3W8X A;  5I1W A;  1E8H A;  3S1E A;  1JRP A;  2Y3R A;  2GQU A;  2QPM A;  2NQW A;  3HSU A;  1QLU A;  1RM6 B;  3RJA A;  2PLS A;  3D2J A;  2VFS A;  2P3H A;  4PZF A;  2YVS A;  2VFU A;  3EUB 3;  2Y08 A;  4UD8 A;  2OAI A;  1DIQ A;  2UUU A;  1WYG A;  1W1O A;  5HMR A;  2PLI A;  4HG0 A;  1E8G A;  1V97 A;  5AE3 A;  3BW7 A;  5G5H B;  5I1V A;  4BBY A;  2MBR A;  1W1R A;  3DQ0 A;  4BCA A;  3ETR B;  2Q85 A;  3C0P A;  4ML8 A;  2EXR A;  4PVE A;  1FO4 A;  1E0Y A;  3VTE A;  1N63 C;  3NRZ B;  5FXD A;  3NVW B;  2BVF A;  1E8F A;  1FIQ B;  1UXY A;  4PWC A;  1FFU C;  3TSJ A;  3PM9 A;  4PVK A;  1F0X A;  1W1J A;  2P13 A;  4BC7 A;  4BC9 A;  5FXE A;  3FW7 A;  1WVE A;  2VAO A;  3TX1 A;  3HRD C;  2I0K A;  3I99 A;  3NVY B;  3NVZ B;  3S1F A;  1W1L A;  2Y4G A;  3EJB B; 
#chains in the Genus database with same CATH homology
 3D2D A;  4PWB A;  3LAE A;  2WDW A;  2E3T A;  2W54 A;  4DNS A;  1AHZ A;  1I19 A;  2VFT A;  4PVH A;  2RK5 A;  1AHV A;  1N5X A;  1JRO A;  5K8E A;  1HSK A;  5HHZ A;  1T3Q C;  2IPI A;  3FW8 A;  2BVG A;  1VAO A;  4XLO A;  1AHU A;  1FFV C;  1WVF A;  3B9J B;  5FXP A;  1N60 C;  4OAL A;  3FW9 A;  3NS1 B;  1DII A;  1VDV A;  4ZOH B;  4PVJ A;  1N62 C;  1W1S A;  3AMZ A;  3RJ8 A;  3DED A;  3PQB A;  3SR6 B;  5L6F A;  3NVV B;  5FXF A;  2W3S A;  3KJM A;  5G5G B;  4PYT A;  5AE2 A;  5HQX A;  2P4P A;  2R8D A;  1DZN A;  2BVH A;  3AN1 A;  4O95 A;  1W1K A;  3W8W A;  2UUV A;  3POP A;  3GSY A;  5L6G A;  4JAY A;  1N5W C;  1MBB A;  3AM9 A;  1ZXI C;  2GQT A;  4MLA A;  1MBT A;  2Q4W A;  2AXR A;  2VFR A;  2W55 A;  1SB3 B;  4JB1 A;  5AWV A;  3LLB A;  1N61 C;  2VFV A;  2O3G A;  2Y3S A;  4EC3 A;  3S1C A;  1W1M A;  3D2H A;  5AE1 A;  1W1Q A;  2R2Z A;  3JS8 A;  1ZR6 A;  2QKN A;  5D79 A;  3W8Z A;  3S1D A;  3TSH A;  1QLT A;  5ADZ A;  3FWA A;  2W3R A;  3W8X A;  5I1W A;  1E8H A;  3S1E A;  1JRP A;  2Y3R A;  2GQU A;  2QPM A;  2NQW A;  3HSU A;  1QLU A;  1RM6 B;  3RJA A;  2PLS A;  3D2J A;  2VFS A;  2P3H A;  4PZF A;  2YVS A;  2VFU A;  3EUB 3;  2Y08 A;  4UD8 A;  2OAI A;  1DIQ A;  2UUU A;  1WYG A;  1W1O A;  5HMR A;  2PLI A;  4HG0 A;  1E8G A;  1V97 A;  5AE3 A;  3BW7 A;  5G5H B;  5I1V A;  4BBY A;  2MBR A;  1W1R A;  3DQ0 A;  4BCA A;  3ETR B;  2Q85 A;  3C0P A;  4ML8 A;  2EXR A;  4PVE A;  1FO4 A;  1E0Y A;  3VTE A;  1N63 C;  3NRZ B;  5FXD A;  3NVW B;  2BVF A;  1E8F A;  1FIQ B;  1UXY A;  4PWC A;  1FFU C;  3TSJ A;  3PM9 A;  4PVK A;  1F0X A;  1W1J A;  2P13 A;  4BC7 A;  4BC9 A;  5FXE A;  3FW7 A;  1WVE A;  2VAO A;  3TX1 A;  3HRD C;  2I0K A;  3I99 A;  3NVZ B;  3S1F A;  3NVY B;  1W1L A;  2Y4G A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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