1E7AA

Crystal structure of human serum albumin complexed with the general anesthetic propofol
Total Genus 212
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
212
sequence length
578
structure length
578
Chain Sequence
SEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Binding of the General Anesthetics Propofol and Halothane to Human Serum Albumin. High Resolution Crystal Structures
pubmed doi rcsb
molecule tags Carrier protein
source organism Homo sapiens
molecule keywords SERUM ALBUMIN
total genus 212
structure length 578
sequence length 578
chains with identical sequence B
ec nomenclature
pdb deposition date 2000-08-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7aA03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7aA02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7aA04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7aA01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7aA06
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7aA05
2BXDA 1HK3A 5DQFA 1HK2A 4N0FD 4F5TA 2BXEA 4IW1A 4JK4A 2XVUA 3LU8A 4J2VA 1O9XA 3JQZA 4K2CA 4LUHA 1BM0A 1LOTA 4PO0A 5ID9A 3TDLA 1MA9A 1E7AA 5DBYA 2BXBA 2BXNA 4LA0A 4G03A 1E7FA 4LB9A 2VUFA 4F5UA 1J78A 1KW2A 5IIHA 1E7HA 4Z69A 1HA2A 1GNJA 4HGMB 5IIXA 2BXLA 5HOZA 4ZBRA 1BJ5A 4S1YA 5ID7A 2VUEA 2BXIA 4LB2A 4OR0A 3B9LA 1HK4A 2I2ZA 1E7BA 5IJFA 1AO6A 3A73A 2XW1A 4L8UA 3V03A 2YDFA 1J7EA 2BXCA 2BXFA 1E78A 1KXPD 3JRYA 1E7EA 3LU6A 4LUFA 4G04A 1E7CA 1HK1A 3CX9A 2BXQA 1E7IA 3B9MA 4IW2A 2BXGA 2XVQA 4F5VA 2BX8A 3V09A 3V08A 5IIUA 4K71A 1UORA 3LU7A 4N0UD 2BXPA 4HGKA 2XVVA 4BKEA 4L9QA 5FUOA 5IFOA 2XVWA 2XW0A 2XSIA 2BXAA 1GNIA 4EMXA 3UIVA 4L9KA 4OT2A 1H9ZA 3SQJA 1TF0A 5IJEA 2BXKA 1BKEA 5IJ5A 4F5SA 2I30A 2BXHA 1HK5A 4ZBQA 5GHKA 1E7GA 4E99A 2BXOA 2VDBA 1N5UA 2BXMA
chains in the Genus database with same CATH superfamily
2JUHA 2BXDA 3WHSA 1HK3A 5DQFA 1HK2A 4N0FD 3G9KD 4F5TA 2BXEA 1VFIA 2OT3A 4IW1A 4JK4A 1H5WA 2XVUA 3LU8A 3VQIA 3FWCC 2K0NA 4J2VA 1O9XA 1MIWA 1SB0A 3JQZA 4ZBKA 4K2CA 4LUHA 1BM0A 1LOTA 4PO0A 5ID9A 3NVIA 1NT2B 4FK5B 1LNSA 3M99C 1MA9A 1E7AA 2GUTA 4GDKB 5DBYA 3TDLA 2BXBA 1MM8A 2Z8KA 2BXNA 4N3ZA 2E0YA 3BPJA 2QM6A 3FNMA 4LA0A 2DBXA 4G01A 2V36A 2KWFA 4G03A 1E7FA 3H3AA 4LB9A 1MIYA 5D7GA 2LXSA 3SIUB 3WHRA 1VZSA 1FOUA 2VUFA 4WA6B 4F5UA 1J78A 1KW2A 5IIHA 2QHBA 1MUSA 1E7HA 4Z69A 1HA2A 1GNJA 3FWBC 4HGMB 2BXLA 5IIXA 5GIOA 5HOZA 1MUHA 4ZBRA 1BJ5A 3GQUA 4S1YA 5ID7A 2VUEA 4MBEC 4ZC6A 5GINA 2BXIA 4LB2A 4W4UB 4OR0A 3B9LA 1HK4A 3MHSB 4ZCGA 3MHHB 2I2ZA 4I9OA 2E0XA 1E7BA 2EFCA 3KIKA 5IJFA 2OZBB 4FIPB 1AO6A 4DM0A 3A75A 3A73A 4D7XA 5BPKA 2XW1A 4L8UA 3KJLA 3V03A 2YDFA 1J7EA 2BXCA 2AGHB 2BXFA 1E78A 1KXPD 2DYMA 2Z8IA 3JRYA 4NAWB 1E7EA 3LU6A 2DG5A 4LUFA 3NMUA 1KDXA 4G04A 1E7CA 2LXTA 2EFEA 4TQ0A 4ZUXV 1HK1A 3PLAA 3CX9A 2CKXA 3W1SA 4BY9C 5B5TA 2BXQA 5GIPA 1E7IA 2Z8JA 3B9MA 4OTUA 2NNWA 2KBZA 4IW2A 2BXGA 2XVQA 4GDXA 2DBUA 4F5VA 2BX8A 4FJCB 4C31B 3V09A 3V08A 5IIUA 2XMOA 4K71A 1UORA 3LU7A 4N0UD 2LQHA 2QMCA 4TQ1A 1IJGA 3GA9L 2BXPA 4HGKA 2XVVA 4BKEA 1JNBA 2EFDA 3NVKA 3NVMA 4L9QA 5FUOA 5IFOA 2XVWA 2LOQA 2XW0A 2XSIA 1TXUA 4DHXB 2BXAA 2NQOA 1GNIA 3ICXA 4GG2A 3H37A 4EMXA 3UIVA 4L9KA 4OT2A 2EFHA 2LQIA 1H9ZA 2DYOA 3SQJA 1TF0A 4GDLB 2AJEA 5IJEA 2BXKA 1MIVA 1BKEA 2ROHA 5IJ5A 4F5SA 3SIVB 4OTTA 3ECPA 2I30A 2BXHA 1HK5A 4ZBQA 5GHKA 1E7GA 3WHQA 4M70B 4E99A 2DBWA 4Z9OA 2BXOA 2VDBA 3GQXA 1N5UA 2BXMA
chains in the Genus database with same CATH topology
2JUHA 2BXDA 3WHSA 1HK3A 5DQFA 1HK2A 4N0FD 3G9KD 4F5TA 2BXEA 1VFIA 2OT3A 4IW1A 4JK4A 1H5WA 2XVUA 3LU8A 3VQIA 3FWCC 4J2VA 1O9XA 1MIWA 3JQZA 4ZBKA 4K2CA 4LUHA 1BM0A 1LOTA 4PO0A 5ID9A 3NVIA 1NT2B 4FK5B 1LNSA 3M99C 1MA9A 1E7AA 5DBYA 4GDKB 3TDLA 2BXBA 2Z8KA 2BXNA 4N3ZA 2E0YA 2QM6A 3FNMA 4LA0A 2DBXA 4G01A 2V36A 4G03A 1E7FA 3H3AA 4LB9A 1MIYA 5D7GA 3SIUB 3WHRA 1VZSA 1FOUA 2VUFA 4WA6B 4F5UA 1J78A 1KW2A 5IIHA 2QHBA 1E7HA 4Z69A 1HA2A 1GNJA 3FWBC 4HGMB 2BXLA 5IIXA 5GIOA 5HOZA 4ZBRA 1BJ5A 3GQUA 4S1YA 5ID7A 2VUEA 4MBEC 4ZC6A 5GINA 2BXIA 4LB2A 4W4UB 4OR0A 3B9LA 1HK4A 3MHSB 4ZCGA 3MHHB 2I2ZA 2E0XA 1E7BA 2EFCA 3KIKA 5IJFA 2OZBB 4FIPB 1AO6A 3A75A 3A73A 5BPKA 2XW1A 4L8UA 3KJLA 3V03A 2YDFA 1J7EA 2BXCA 2BXFA 1E78A 1KXPD 2DYMA 2Z8IA 3JRYA 4NAWB 1E7EA 3LU6A 2DG5A 4LUFA 3NMUA 4G04A 1E7CA 2EFEA 4TQ0A 4ZUXV 1HK1A 3PLAA 3CX9A 2CKXA 3W1SA 4BY9C 5B5TA 2BXQA 5GIPA 1E7IA 2Z8JA 3B9MA 4OTUA 2NNWA 2KBZA 4IW2A 2BXGA 2XVQA 4GDXA 2DBUA 4F5VA 2BX8A 4FJCB 4C31B 3V09A 3V08A 5IIUA 2XMOA 4K71A 1UORA 3LU7A 4N0UD 2QMCA 4TQ1A 1IJGA 3GA9L 2BXPA 4HGKA 2XVVA 4BKEA 1JNBA 2EFDA 3NVKA 3NVMA 4L9QA 5FUOA 5IFOA 2XVWA 2LOQA 2XW0A 2XSIA 1TXUA 4DHXB 2BXAA 2NQOA 1GNIA 3ICXA 4GG2A 3H37A 4EMXA 3UIVA 4L9KA 4OT2A 2EFHA 1H9ZA 2DYOA 3SQJA 1TF0A 4GDLB 2AJEA 5IJEA 2BXKA 1MIVA 1BKEA 2ROHA 5IJ5A 4F5SA 3SIVB 4OTTA 2I30A 2BXHA 1HK5A 4ZBQA 5GHKA 1E7GA 3WHQA 4M70B 4E99A 2DBWA 4Z9OA 2BXOA 2VDBA 3GQXA 1N5UA 2BXMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BXD A;  1HK3 A;  5DQF A;  1HK2 A;  4N0F D;  4F5T A;  2BXE A;  4IW1 A;  4JK4 A;  2XVU A;  3LU8 A;  4J2V A;  1O9X A;  3JQZ A;  4K2C A;  4LUH A;  1BM0 A;  1LOT A;  4PO0 A;  5ID9 A;  3TDL A;  1MA9 A;  1E7A A;  5DBY A;  2BXB A;  2BXN A;  4LA0 A;  4G03 A;  1E7F A;  4LB9 A;  2VUF A;  4F5U A;  1J78 A;  1KW2 A;  5IIH A;  1E7H A;  4Z69 A;  1HA2 A;  1GNJ A;  4HGM B;  5IIX A;  2BXL A;  5HOZ A;  4ZBR A;  1BJ5 A;  4S1Y A;  5ID7 A;  2VUE A;  2BXI A;  4LB2 A;  4OR0 A;  3B9L A;  1HK4 A;  2I2Z A;  1E7B A;  5IJF A;  1AO6 A;  3A73 A;  2XW1 A;  4L8U A;  3V03 A;  2YDF A;  1J7E A;  2BXC A;  2BXF A;  1E78 A;  1KXP D;  3JRY A;  1E7E A;  3LU6 A;  4LUF A;  4G04 A;  1E7C A;  1HK1 A;  3CX9 A;  2BXQ A;  1E7I A;  3B9M A;  4IW2 A;  2BXG A;  2XVQ A;  4F5V A;  2BX8 A;  3V09 A;  3V08 A;  5IIU A;  4K71 A;  1UOR A;  3LU7 A;  4N0U D;  2BXP A;  4HGK A;  2XVV A;  4BKE A;  4L9Q A;  5FUO A;  5IFO A;  2XVW A;  2XW0 A;  2XSI A;  2BXA A;  1GNI A;  4EMX A;  3UIV A;  4L9K A;  4OT2 A;  1H9Z A;  3SQJ A;  1TF0 A;  5IJE A;  2BXK A;  1BKE A;  5IJ5 A;  4F5S A;  2I30 A;  2BXH A;  1HK5 A;  4ZBQ A;  5GHK A;  1E7G A;  4E99 A;  2BXO A;  2VDB A;  1N5U A;  2BXM A; 
#chains in the Genus database with same CATH topology
 2JUH A;  2BXD A;  3WHS A;  1HK3 A;  5DQF A;  1HK2 A;  4N0F D;  3G9K D;  4F5T A;  2BXE A;  1VFI A;  2OT3 A;  4IW1 A;  4JK4 A;  1H5W A;  2XVU A;  3LU8 A;  3VQI A;  3FWC C;  2K0N A;  4J2V A;  1O9X A;  1MIW A;  1SB0 A;  3JQZ A;  4ZBK A;  4K2C A;  4LUH A;  1BM0 A;  1LOT A;  4PO0 A;  5ID9 A;  3NVI A;  1NT2 B;  4FK5 B;  1LNS A;  3M99 C;  1MA9 A;  1E7A A;  2GUT A;  4GDK B;  5DBY A;  3TDL A;  2BXB A;  1MM8 A;  2Z8K A;  2BXN A;  4N3Z A;  2E0Y A;  3BPJ A;  2QM6 A;  3FNM A;  4LA0 A;  2DBX A;  4G01 A;  2V36 A;  2KWF A;  4G03 A;  1E7F A;  3H3A A;  4LB9 A;  1MIY A;  5D7G A;  2LXS A;  3SIU B;  3WHR A;  1VZS A;  1FOU A;  2VUF A;  4WA6 B;  4F5U A;  1J78 A;  1KW2 A;  5IIH A;  2QHB A;  1MUS A;  1E7H A;  4Z69 A;  1HA2 A;  1GNJ A;  3FWB C;  4HGM B;  2BXL A;  5IIX A;  5GIO A;  5HOZ A;  1MUH A;  4ZBR A;  1BJ5 A;  3GQU A;  4S1Y A;  5ID7 A;  2VUE A;  4MBE C;  4ZC6 A;  5GIN A;  2BXI A;  4LB2 A;  4W4U B;  4OR0 A;  3B9L A;  1HK4 A;  3MHS B;  4ZCG A;  3MHH B;  2I2Z A;  4I9O A;  2E0X A;  1E7B A;  2EFC A;  3KIK A;  5IJF A;  2OZB B;  4FIP B;  1AO6 A;  4DM0 A;  3A75 A;  3A73 A;  4D7X A;  5BPK A;  2XW1 A;  4L8U A;  3KJL A;  3V03 A;  2YDF A;  1J7E A;  2BXC A;  2AGH B;  2BXF A;  1E78 A;  1KXP D;  2DYM A;  2Z8I A;  3JRY A;  4NAW B;  1E7E A;  3LU6 A;  2DG5 A;  4LUF A;  3NMU A;  1KDX A;  4G04 A;  1E7C A;  2LXT A;  2EFE A;  4TQ0 A;  4ZUX V;  1HK1 A;  3PLA A;  3CX9 A;  2CKX A;  3W1S A;  4BY9 C;  5B5T A;  2BXQ A;  5GIP A;  1E7I A;  2Z8J A;  3B9M A;  4OTU A;  2NNW A;  2KBZ A;  4IW2 A;  2BXG A;  2XVQ A;  4GDX A;  2DBU A;  4F5V A;  2BX8 A;  4FJC B;  4C31 B;  3V09 A;  3V08 A;  5IIU A;  2XMO A;  4K71 A;  1UOR A;  3LU7 A;  4N0U D;  2LQH A;  2QMC A;  4TQ1 A;  1IJG A;  3GA9 L;  2BXP A;  4HGK A;  2XVV A;  4BKE A;  1JNB A;  2EFD A;  3NVK A;  3NVM A;  4L9Q A;  5FUO A;  5IFO A;  2XVW A;  2LOQ A;  2XW0 A;  2XSI A;  1TXU A;  4DHX B;  2BXA A;  2NQO A;  1GNI A;  3ICX A;  4GG2 A;  3H37 A;  4EMX A;  3UIV A;  4L9K A;  4OT2 A;  2EFH A;  2LQI A;  1H9Z A;  2DYO A;  3SQJ A;  1TF0 A;  4GDL B;  2AJE A;  5IJE A;  2BXK A;  1MIV A;  1BKE A;  2ROH A;  5IJ5 A;  4F5S A;  3SIV B;  4OTT A;  3ECP A;  2I30 A;  2BXH A;  1HK5 A;  4ZBQ A;  5GHK A;  1E7G A;  3WHQ A;  4M70 B;  4E99 A;  2DBW A;  4Z9O A;  2BXO A;  2VDB A;  3GQX A;  1N5U A;  2BXM A; 
#chains in the Genus database with same CATH homology
 2JUH A;  2BXD A;  3WHS A;  1HK3 A;  5DQF A;  1HK2 A;  4N0F D;  3G9K D;  4F5T A;  2BXE A;  1VFI A;  2OT3 A;  4IW1 A;  4JK4 A;  1H5W A;  2XVU A;  3LU8 A;  3VQI A;  3FWC C;  4J2V A;  1O9X A;  1MIW A;  3JQZ A;  4ZBK A;  4K2C A;  4LUH A;  1BM0 A;  1LOT A;  4PO0 A;  5ID9 A;  3NVI A;  1NT2 B;  4FK5 B;  1LNS A;  3M99 C;  1MA9 A;  1E7A A;  5DBY A;  4GDK B;  3TDL A;  2BXB A;  2Z8K A;  2BXN A;  4N3Z A;  2E0Y A;  2QM6 A;  3FNM A;  4LA0 A;  2DBX A;  4G01 A;  2V36 A;  4G03 A;  1E7F A;  3H3A A;  4LB9 A;  1MIY A;  5D7G A;  3SIU B;  3WHR A;  1VZS A;  1FOU A;  2VUF A;  4WA6 B;  4F5U A;  1J78 A;  1KW2 A;  5IIH A;  2QHB A;  1E7H A;  4Z69 A;  1HA2 A;  1GNJ A;  3FWB C;  4HGM B;  2BXL A;  5IIX A;  5GIO A;  5HOZ A;  4ZBR A;  1BJ5 A;  3GQU A;  4S1Y A;  5ID7 A;  2VUE A;  4MBE C;  4ZC6 A;  5GIN A;  2BXI A;  4LB2 A;  4W4U B;  4OR0 A;  3B9L A;  1HK4 A;  3MHS B;  4ZCG A;  3MHH B;  2I2Z A;  2E0X A;  1E7B A;  2EFC A;  3KIK A;  5IJF A;  2OZB B;  4FIP B;  1AO6 A;  3A75 A;  3A73 A;  5BPK A;  2XW1 A;  4L8U A;  3KJL A;  3V03 A;  2YDF A;  1J7E A;  2BXC A;  2BXF A;  1E78 A;  1KXP D;  2DYM A;  2Z8I A;  3JRY A;  4NAW B;  1E7E A;  3LU6 A;  2DG5 A;  4LUF A;  3NMU A;  4G04 A;  1E7C A;  2EFE A;  4TQ0 A;  4ZUX V;  1HK1 A;  3PLA A;  3CX9 A;  2CKX A;  3W1S A;  4BY9 C;  5B5T A;  2BXQ A;  5GIP A;  1E7I A;  2Z8J A;  3B9M A;  4OTU A;  2NNW A;  2KBZ A;  4IW2 A;  2BXG A;  2XVQ A;  4GDX A;  2DBU A;  4F5V A;  2BX8 A;  4FJC B;  4C31 B;  3V09 A;  3V08 A;  5IIU A;  2XMO A;  4K71 A;  1UOR A;  3LU7 A;  4N0U D;  2QMC A;  4TQ1 A;  1IJG A;  3GA9 L;  2BXP A;  4HGK A;  2XVV A;  4BKE A;  1JNB A;  2EFD A;  3NVK A;  3NVM A;  4L9Q A;  5FUO A;  5IFO A;  2XVW A;  2LOQ A;  2XW0 A;  2XSI A;  1TXU A;  4DHX B;  2BXA A;  2NQO A;  1GNI A;  3ICX A;  4GG2 A;  3H37 A;  4EMX A;  3UIV A;  4L9K A;  4OT2 A;  2EFH A;  1H9Z A;  2DYO A;  3SQJ A;  1TF0 A;  4GDL B;  2AJE A;  5IJE A;  2BXK A;  1MIV A;  1BKE A;  2ROH A;  5IJ5 A;  4F5S A;  3SIV B;  4OTT A;  2I30 A;  2BXH A;  1HK5 A;  4ZBQ A;  5GHK A;  1E7G A;  3WHQ A;  4M70 B;  4E99 A;  2DBW A;  4Z9O A;  2BXO A;  2VDB A;  3GQX A;  1N5U A;  2BXM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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