1E7BA

Crystal structure of human serum albumin complexed with the general anesthetic halothane
Total Genus 197
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
197
sequence length
578
structure length
578
Chain Sequence
SEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords SERUM ALBUMIN
publication title Binding of the General Anesthetics Propofol and Halothane to Human Serum Albumin. High Resolution Crystal Structures
pubmed doi rcsb
source organism Homo sapiens
molecule tags Carrier protein
total genus 197
structure length 578
sequence length 578
chains with identical sequence B
ec nomenclature
pdb deposition date 2000-08-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7bA03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7bA02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7bA04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7bA01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7bA06
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7bA05
4F5UA 1HA2A 3JRYA 1HK4A 3B9LA 4ZBRA 2XVUA 4PO0A 2XVWA 1AO6A 5GHKA 1GNJA 4L9QA 1HK1A 1E7IA 3JQZA 2BXPA 1J7EA 2BXGA 2BXIA 5IIXA 3CX9A 4F5TA 4Z69A 3LU8A 3LU6A 1BKEA 1HK3A 4F5SA 1TF0A 4L8UA 1E7FA 3V08A 5ID7A 2XVQA 5ID9A 1O9XA 3V03A 4HGMB 4ZBQA 3B9MA 5FUOA 4F5VA 2VDBA 2XVVA 5IFOA 5IIHA 2BXOA 3SQJA 3V09A 1HK2A 2XSIA 1E7HA 4HGKA 4EMXA 4JK4A 1E7BA 1E78A 5IJ5A 2BXDA 3LU7A 2BXNA 4IW2A 2BXMA 1E7CA 2BXKA 1E7AA 2I30A 5HOZA 4S1YA 2VUEA 1UORA 4J2VA 1KXPD 4LUFA 1BJ5A 4N0UD 2YDFA 2XW1A 4LB2A 3UIVA 2XW0A 2BXAA 4OT2A 1LOTA 5DQFA 1E7GA 4L9KA 4BKEA 2BXFA 2BXEA 4N0FD 4K2CA 4OR0A 1GNIA 2BXLA 1H9ZA 3A73A 2I2ZA 2VUFA 4E99A 1E7EA 4IW1A 1HK5A 2BXBA 2BXCA 4G03A 2BXHA 1MA9A 4G04A 3TDLA 4LA0A 5IIUA 5IJEA 2BX8A 5DBYA 5IJFA 2BXQA 4K71A 1BM0A 4LB9A 1N5UA 1J78A 4LUHA 1KW2A
chains in the Genus database with same CATH superfamily
4F5UA 3FNMA 1HA2A 3JRYA 1HK4A 3B9LA 4GDXA 4N3ZA 2XVUA 4ZBRA 4FIPB 4PO0A 2XVWA 4ZBKA 1AO6A 5GHKA 1GNJA 3FWCC 4L9QA 3PLAA 1HK1A 1E7IA 3JQZA 2BXPA 1J7EA 2BXGA 2EFEA 2BXIA 4FK5B 2DBWA 5IIXA 4I9OA 3CX9A 4F5TA 3NVKA 2EFCA 4Z69A 3LU8A 1JNBA 3NMUA 1FOUA 1MIWA 3LU6A 1BKEA 1HK3A 1KDXA 4F5SA 3KIKA 1TF0A 2KBZA 2CKXA 2KWFA 1MUHA 3M99C 4L8UA 1E7FA 4W4UB 3V08A 5ID7A 2E0YA 2XVQA 2Z8IA 5ID9A 5GIPA 1O9XA 2LOQA 3V03A 4HGMB 1MIVA 2Z8KA 4ZBQA 2LXSA 3B9MA 5FUOA 4F5VA 2VDBA 2DYMA 2XVVA 5IFOA 5IIHA 2BXOA 3KJLA 2DBXA 3SQJA 3V09A 3VQIA 3WHQA 2DG5A 1HK2A 2XSIA 1MUSA 1E7HA 2XMOA 4MBEC 1LNSA 1VZSA 2NQOA 3MHHB 4HGKA 4EMXA 4JK4A 1E7BA 4GDLB 1E78A 2DBUA 4Z9OA 3SIVB 3A75A 5IJ5A 2BXDA 4OTUA 4DM0A 4ZC6A 3LU7A 4FJCB 2BXNA 4IW2A 2BXMA 3GQXA 4TQ0A 1E7CA 2BXKA 1E7AA 2I30A 4M70B 5HOZA 4DHXB 1TXUA 4S1YA 2EFDA 2VUEA 4ZCGA 2K0NA 4NAWB 3G9KD 1UORA 4ZUXV 4J2VA 4BY9C 2OT3A 2LQHA 1MM8A 1KXPD 3ICXA 4OTTA 4LUFA 1BJ5A 3NVMA 2LXTA 4N0UD 2YDFA 2GUTA 1SB0A 2XW1A 4LB2A 4WA6B 3UIVA 4TQ1A 2XW0A 2BXAA 4OT2A 5GINA 5GIOA 1LOTA 5DQFA 1IJGA 1H5WA 1E7GA 4L9KA 4BKEA 4D7XA 2BXFA 2JUHA 3SIUB 2BXEA 2QM6A 3GA9L 2AJEA 4N0FD 4K2CA 2QHBA 4OR0A 1GNIA 2AGHB 2BXLA 4C31B 1H9ZA 3W1SA 1MIYA 3A73A 2I2ZA 2E0XA 2NNWA 5D7GA 2VUFA 4E99A 2ROHA 1E7EA 1VFIA 2Z8JA 4IW1A 3FWBC 1HK5A 2BXBA 3H3AA 2BXCA 4G03A 3H37A 2BXHA 5B5TA 3BPJA 1MA9A 4G04A 3TDLA 3WHRA 1NT2B 4LA0A 5IIUA 2V36A 2EFHA 5IJEA 5BPKA 2BX8A 2QMCA 2OZBB 2DYOA 2LQIA 3MHSB 5DBYA 4GDKB 5IJFA 2BXQA 4K71A 3NVIA 3WHSA 1BM0A 4LB9A 1N5UA 3GQUA 4GG2A 1J78A 4G01A 4LUHA 3ECPA 1KW2A
chains in the Genus database with same CATH topology
4F5UA 3FNMA 1HA2A 3JRYA 1HK4A 3B9LA 4GDXA 4N3ZA 2XVUA 4ZBRA 4FIPB 4PO0A 2XVWA 4ZBKA 1AO6A 5GHKA 1GNJA 3FWCC 4L9QA 3PLAA 1HK1A 1E7IA 3JQZA 2BXPA 1J7EA 2BXGA 2EFEA 2BXIA 4FK5B 2DBWA 5IIXA 3CX9A 4F5TA 3NVKA 2EFCA 4Z69A 3LU8A 1JNBA 3NMUA 1FOUA 1MIWA 3LU6A 1BKEA 1HK3A 4F5SA 3KIKA 1TF0A 2KBZA 2CKXA 3M99C 4L8UA 1E7FA 4W4UB 3V08A 5ID7A 2E0YA 2XVQA 2Z8IA 5ID9A 5GIPA 1O9XA 2LOQA 3V03A 4HGMB 1MIVA 2Z8KA 4ZBQA 3B9MA 5FUOA 4F5VA 2VDBA 2DYMA 2XVVA 5IFOA 5IIHA 2BXOA 3KJLA 2DBXA 3SQJA 3V09A 3VQIA 3WHQA 2DG5A 1HK2A 2XSIA 1E7HA 2XMOA 4MBEC 1LNSA 1VZSA 2NQOA 3MHHB 4HGKA 4EMXA 4JK4A 1E7BA 4GDLB 1E78A 2DBUA 4Z9OA 3SIVB 3A75A 5IJ5A 2BXDA 4OTUA 4ZC6A 3LU7A 4FJCB 2BXNA 4IW2A 2BXMA 3GQXA 4TQ0A 1E7CA 2BXKA 1E7AA 2I30A 4M70B 5HOZA 4DHXB 1TXUA 4S1YA 2EFDA 2VUEA 4ZCGA 4NAWB 3G9KD 1UORA 4ZUXV 4J2VA 4BY9C 2OT3A 1KXPD 3ICXA 4OTTA 4LUFA 1BJ5A 3NVMA 4N0UD 2YDFA 2XW1A 4LB2A 4WA6B 3UIVA 4TQ1A 2XW0A 2BXAA 4OT2A 5GINA 5GIOA 1LOTA 5DQFA 1IJGA 1H5WA 1E7GA 4L9KA 4BKEA 2BXFA 2JUHA 3SIUB 2BXEA 2QM6A 3GA9L 2AJEA 4N0FD 4K2CA 2QHBA 4OR0A 1GNIA 2BXLA 4C31B 1H9ZA 3W1SA 1MIYA 3A73A 2I2ZA 2E0XA 2NNWA 5D7GA 2VUFA 4E99A 2ROHA 1E7EA 1VFIA 2Z8JA 4IW1A 3FWBC 1HK5A 2BXBA 3H3AA 2BXCA 4G03A 3H37A 2BXHA 5B5TA 1MA9A 4G04A 3TDLA 3WHRA 1NT2B 4LA0A 5IIUA 2V36A 2EFHA 5IJEA 5BPKA 2BX8A 2QMCA 2OZBB 2DYOA 3MHSB 5DBYA 4GDKB 5IJFA 2BXQA 4K71A 3NVIA 3WHSA 1BM0A 4LB9A 1N5UA 3GQUA 4GG2A 1J78A 4G01A 4LUHA 1KW2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4F5U A;  1HA2 A;  3JRY A;  1HK4 A;  3B9L A;  4ZBR A;  2XVU A;  4PO0 A;  2XVW A;  1AO6 A;  5GHK A;  1GNJ A;  4L9Q A;  1HK1 A;  1E7I A;  3JQZ A;  2BXP A;  1J7E A;  2BXG A;  2BXI A;  5IIX A;  3CX9 A;  4F5T A;  4Z69 A;  3LU8 A;  3LU6 A;  1BKE A;  1HK3 A;  4F5S A;  1TF0 A;  4L8U A;  1E7F A;  3V08 A;  5ID7 A;  2XVQ A;  5ID9 A;  1O9X A;  3V03 A;  4HGM B;  4ZBQ A;  3B9M A;  5FUO A;  4F5V A;  2VDB A;  2XVV A;  5IFO A;  5IIH A;  2BXO A;  3SQJ A;  3V09 A;  1HK2 A;  2XSI A;  1E7H A;  4HGK A;  4EMX A;  4JK4 A;  1E7B A;  1E78 A;  5IJ5 A;  2BXD A;  3LU7 A;  2BXN A;  4IW2 A;  2BXM A;  1E7C A;  2BXK A;  1E7A A;  2I30 A;  5HOZ A;  4S1Y A;  2VUE A;  1UOR A;  4J2V A;  1KXP D;  4LUF A;  1BJ5 A;  4N0U D;  2YDF A;  2XW1 A;  4LB2 A;  3UIV A;  2XW0 A;  2BXA A;  4OT2 A;  1LOT A;  5DQF A;  1E7G A;  4L9K A;  4BKE A;  2BXF A;  2BXE A;  4N0F D;  4K2C A;  4OR0 A;  1GNI A;  2BXL A;  1H9Z A;  3A73 A;  2I2Z A;  2VUF A;  4E99 A;  1E7E A;  4IW1 A;  1HK5 A;  2BXB A;  2BXC A;  4G03 A;  2BXH A;  1MA9 A;  4G04 A;  3TDL A;  4LA0 A;  5IIU A;  5IJE A;  2BX8 A;  5DBY A;  5IJF A;  2BXQ A;  4K71 A;  1BM0 A;  4LB9 A;  1N5U A;  1J78 A;  4LUH A;  1KW2 A; 
#chains in the Genus database with same CATH topology
 4F5U A;  3FNM A;  1HA2 A;  3JRY A;  1HK4 A;  3B9L A;  4GDX A;  4N3Z A;  2XVU A;  4ZBR A;  4FIP B;  4PO0 A;  2XVW A;  4ZBK A;  1AO6 A;  5GHK A;  1GNJ A;  3FWC C;  4L9Q A;  3PLA A;  1HK1 A;  1E7I A;  3JQZ A;  2BXP A;  1J7E A;  2BXG A;  2EFE A;  2BXI A;  4FK5 B;  2DBW A;  5IIX A;  4I9O A;  3CX9 A;  4F5T A;  3NVK A;  2EFC A;  4Z69 A;  3LU8 A;  1JNB A;  3NMU A;  1FOU A;  1MIW A;  3LU6 A;  1BKE A;  1HK3 A;  1KDX A;  4F5S A;  3KIK A;  1TF0 A;  2KBZ A;  2CKX A;  2KWF A;  1MUH A;  3M99 C;  4L8U A;  1E7F A;  4W4U B;  3V08 A;  5ID7 A;  2E0Y A;  2XVQ A;  2Z8I A;  5ID9 A;  5GIP A;  1O9X A;  2LOQ A;  3V03 A;  4HGM B;  1MIV A;  2Z8K A;  4ZBQ A;  2LXS A;  3B9M A;  5FUO A;  4F5V A;  2VDB A;  2DYM A;  2XVV A;  5IFO A;  5IIH A;  2BXO A;  3KJL A;  2DBX A;  3SQJ A;  3V09 A;  3VQI A;  3WHQ A;  2DG5 A;  1HK2 A;  2XSI A;  1MUS A;  1E7H A;  2XMO A;  4MBE C;  1LNS A;  1VZS A;  2NQO A;  3MHH B;  4HGK A;  4EMX A;  4JK4 A;  1E7B A;  4GDL B;  1E78 A;  2DBU A;  4Z9O A;  3SIV B;  3A75 A;  5IJ5 A;  2BXD A;  4OTU A;  4DM0 A;  4ZC6 A;  3LU7 A;  4FJC B;  2BXN A;  4IW2 A;  2BXM A;  3GQX A;  4TQ0 A;  1E7C A;  2BXK A;  1E7A A;  2I30 A;  4M70 B;  5HOZ A;  4DHX B;  1TXU A;  4S1Y A;  2EFD A;  2VUE A;  4ZCG A;  2K0N A;  4NAW B;  3G9K D;  1UOR A;  4ZUX V;  4J2V A;  4BY9 C;  2OT3 A;  2LQH A;  1MM8 A;  1KXP D;  3ICX A;  4OTT A;  4LUF A;  1BJ5 A;  3NVM A;  2LXT A;  4N0U D;  2YDF A;  2GUT A;  1SB0 A;  2XW1 A;  4LB2 A;  4WA6 B;  3UIV A;  4TQ1 A;  2XW0 A;  2BXA A;  4OT2 A;  5GIN A;  5GIO A;  1LOT A;  5DQF A;  1IJG A;  1H5W A;  1E7G A;  4L9K A;  4BKE A;  4D7X A;  2BXF A;  2JUH A;  3SIU B;  2BXE A;  2QM6 A;  3GA9 L;  2AJE A;  4N0F D;  4K2C A;  2QHB A;  4OR0 A;  1GNI A;  2AGH B;  2BXL A;  4C31 B;  1H9Z A;  3W1S A;  1MIY A;  3A73 A;  2I2Z A;  2E0X A;  2NNW A;  5D7G A;  2VUF A;  4E99 A;  2ROH A;  1E7E A;  1VFI A;  2Z8J A;  4IW1 A;  3FWB C;  1HK5 A;  2BXB A;  3H3A A;  2BXC A;  4G03 A;  3H37 A;  2BXH A;  5B5T A;  3BPJ A;  1MA9 A;  4G04 A;  3TDL A;  3WHR A;  1NT2 B;  4LA0 A;  5IIU A;  2V36 A;  2EFH A;  5IJE A;  5BPK A;  2BX8 A;  2QMC A;  2OZB B;  2DYO A;  2LQI A;  3MHS B;  5DBY A;  4GDK B;  5IJF A;  2BXQ A;  4K71 A;  3NVI A;  3WHS A;  1BM0 A;  4LB9 A;  1N5U A;  3GQU A;  4GG2 A;  1J78 A;  4G01 A;  4LUH A;  3ECP A;  1KW2 A; 
#chains in the Genus database with same CATH homology
 4F5U A;  3FNM A;  1HA2 A;  3JRY A;  1HK4 A;  3B9L A;  4GDX A;  4N3Z A;  2XVU A;  4ZBR A;  4FIP B;  4PO0 A;  2XVW A;  4ZBK A;  1AO6 A;  5GHK A;  1GNJ A;  3FWC C;  4L9Q A;  3PLA A;  1HK1 A;  1E7I A;  3JQZ A;  2BXP A;  1J7E A;  2BXG A;  2EFE A;  2BXI A;  4FK5 B;  2DBW A;  5IIX A;  3CX9 A;  4F5T A;  3NVK A;  2EFC A;  4Z69 A;  3LU8 A;  1JNB A;  3NMU A;  1FOU A;  1MIW A;  3LU6 A;  1BKE A;  1HK3 A;  4F5S A;  3KIK A;  1TF0 A;  2KBZ A;  2CKX A;  3M99 C;  4L8U A;  1E7F A;  4W4U B;  3V08 A;  5ID7 A;  2E0Y A;  2XVQ A;  2Z8I A;  5ID9 A;  5GIP A;  1O9X A;  2LOQ A;  3V03 A;  4HGM B;  1MIV A;  2Z8K A;  4ZBQ A;  3B9M A;  5FUO A;  4F5V A;  2VDB A;  2DYM A;  2XVV A;  5IFO A;  5IIH A;  2BXO A;  3KJL A;  2DBX A;  3SQJ A;  3V09 A;  3VQI A;  3WHQ A;  2DG5 A;  1HK2 A;  2XSI A;  1E7H A;  2XMO A;  4MBE C;  1LNS A;  1VZS A;  2NQO A;  3MHH B;  4HGK A;  4EMX A;  4JK4 A;  1E7B A;  4GDL B;  1E78 A;  2DBU A;  4Z9O A;  3SIV B;  3A75 A;  5IJ5 A;  2BXD A;  4OTU A;  4ZC6 A;  3LU7 A;  4FJC B;  2BXN A;  4IW2 A;  2BXM A;  3GQX A;  4TQ0 A;  1E7C A;  2BXK A;  1E7A A;  2I30 A;  4M70 B;  5HOZ A;  4DHX B;  1TXU A;  4S1Y A;  2EFD A;  2VUE A;  4ZCG A;  4NAW B;  3G9K D;  1UOR A;  4ZUX V;  4J2V A;  4BY9 C;  2OT3 A;  1KXP D;  3ICX A;  4OTT A;  4LUF A;  1BJ5 A;  3NVM A;  4N0U D;  2YDF A;  2XW1 A;  4LB2 A;  4WA6 B;  3UIV A;  4TQ1 A;  2XW0 A;  2BXA A;  4OT2 A;  5GIN A;  5GIO A;  1LOT A;  5DQF A;  1IJG A;  1H5W A;  1E7G A;  4L9K A;  4BKE A;  2BXF A;  2JUH A;  3SIU B;  2BXE A;  2QM6 A;  3GA9 L;  2AJE A;  4N0F D;  4K2C A;  2QHB A;  4OR0 A;  1GNI A;  2BXL A;  4C31 B;  1H9Z A;  3W1S A;  1MIY A;  3A73 A;  2I2Z A;  2E0X A;  2NNW A;  5D7G A;  2VUF A;  4E99 A;  2ROH A;  1E7E A;  1VFI A;  2Z8J A;  4IW1 A;  3FWB C;  1HK5 A;  2BXB A;  3H3A A;  2BXC A;  4G03 A;  3H37 A;  2BXH A;  5B5T A;  1MA9 A;  4G04 A;  3TDL A;  3WHR A;  1NT2 B;  4LA0 A;  5IIU A;  2V36 A;  2EFH A;  5IJE A;  5BPK A;  2BX8 A;  2QMC A;  2OZB B;  2DYO A;  3MHS B;  5DBY A;  4GDK B;  5IJF A;  2BXQ A;  4K71 A;  3NVI A;  3WHS A;  1BM0 A;  4LB9 A;  1N5U A;  3GQU A;  4GG2 A;  1J78 A;  4G01 A;  4LUH A;  1KW2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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