1E7BA

Crystal structure of human serum albumin complexed with the general anesthetic halothane
Total Genus 197
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
197
sequence length
578
structure length
578
Chain Sequence
SEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Binding of the General Anesthetics Propofol and Halothane to Human Serum Albumin. High Resolution Crystal Structures
pubmed doi rcsb
molecule keywords SERUM ALBUMIN
molecule tags Carrier protein
source organism Homo sapiens
total genus 197
structure length 578
sequence length 578
chains with identical sequence B
ec nomenclature
pdb deposition date 2000-08-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7bA03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7bA02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7bA04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7bA01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7bA06
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7bA05
3LU8A 3V03A 2VUFA 2BXPA 4HGMB 2XVWA 5IJFA 2XW0A 4ZBQA 2BX8A 2BXAA 4E99A 1O9XA 4ZBRA 1E7FA 5IFOA 1HK3A 1KW2A 1HA2A 4F5TA 1KXPD 2XVUA 4OR0A 1LOTA 1HK4A 4G03A 2BXOA 4OT2A 5IJ5A 5GHKA 3SQJA 4L9KA 1J7EA 4J2VA 1H9ZA 3JQZA 2I30A 4LUFA 2BXMA 2YDFA 3LU7A 1UORA 5IIHA 4G04A 2BXEA 4L8UA 3LU6A 4LB2A 4N0UD 1E7BA 2BXBA 1E7IA 2BXQA 3JRYA 2BXCA 1N5UA 3A73A 4EMXA 1HK2A 3TDLA 4K2CA 1BM0A 2I2ZA 1AO6A 5DBYA 1E78A 5ID7A 1GNIA 4K71A 2BXLA 1E7HA 1BKEA 1HK1A 5ID9A 1E7EA 4HGKA 4F5VA 4LA0A 5IIXA 3UIVA 2BXHA 2XW1A 4LUHA 1J78A 4Z69A 3V09A 1MA9A 4L9QA 3V08A 4JK4A 1E7CA 2BXFA 4IW1A 2XSIA 2VDBA 5HOZA 4F5UA 2BXGA 1GNJA 2XVVA 4BKEA 2XVQA 1BJ5A 1HK5A 2BXKA 3CX9A 5FUOA 3B9MA 2VUEA 3B9LA 5IIUA 2BXIA 2BXDA 4N0FD 4PO0A 4S1YA 5IJEA 1E7AA 1E7GA 4LB9A 2BXNA 5DQFA 1TF0A 4F5SA 4IW2A
chains in the Genus database with same CATH superfamily
2AGHB 3LU8A 4DM0A 3V03A 4ZBKA 2VUFA 2BXPA 3GQUA 4HGMB 2XVWA 3FWCC 2DG5A 4ZUXV 5IJFA 2KWFA 2JUHA 2EFCA 2EFDA 2XW0A 4OTTA 2BX8A 4ZBQA 3PLAA 2BXAA 4GDLB 4E99A 1O9XA 3FNMA 4GG2A 2QMCA 4ZBRA 1E7FA 5IFOA 4BY9C 3NVKA 5GIOA 1HK3A 5GINA 1IJGA 4C31B 4GDXA 1KW2A 1HA2A 3FWBC 1H5WA 4TQ0A 2DBUA 4F5TA 4DHXB 1KXPD 2XVUA 4I9OA 3M99C 3H3AA 2ROHA 4OR0A 3ECPA 1NT2B 2NNWA 1LOTA 3GA9L 5BPKA 1HK4A 4G03A 2BXOA 4OT2A 5IJ5A 5GHKA 3SQJA 4L9KA 1J7EA 4J2VA 4NAWB 1H9ZA 3BPJA 3JQZA 2I30A 4LUFA 1SB0A 3NVMA 4GDKB 2CKXA 2BXMA 3GQXA 2YDFA 4FJCB 2V36A 1MIVA 3LU7A 1UORA 1JNBA 4ZC6A 2QHBA 4TQ1A 5IIHA 4W4UB 4G04A 2LXTA 2BXEA 1MUHA 4L8UA 3LU6A 4LB2A 4N0UD 1E7BA 2BXBA 4N3ZA 4OTUA 1E7IA 2LOQA 1MIYA 2BXQA 2QM6A 3JRYA 2BXCA 1N5UA 2E0XA 3A73A 4EMXA 1HK2A 3TDLA 4K2CA 2DBXA 3W1SA 1BM0A 2EFHA 2KBZA 2I2ZA 1AO6A 5DBYA 1E78A 3VQIA 1TXUA 1GNIA 5ID7A 4D7XA 4M70B 2E0YA 1LNSA 1MIWA 2Z8IA 3KIKA 4K71A 2BXLA 3MHHB 4MBEC 3SIVB 2Z8KA 1E7HA 1BKEA 3A75A 5B5TA 1HK1A 3H37A 4FK5B 1E7EA 4HGKA 4F5VA 2AJEA 1VFIA 4LA0A 5ID9A 3UIVA 5IIXA 2BXHA 2XW1A 4LUHA 3NMUA 1J78A 4Z69A 2Z8JA 3V09A 1MA9A 2LXSA 4L9QA 3V08A 4JK4A 1E7CA 2BXFA 2VDBA 2XSIA 4IW1A 2DYMA 1MM8A 5HOZA 3WHRA 4F5UA 2BXGA 1GNJA 1VZSA 2LQHA 2OZBB 3WHSA 3ICXA 2XVVA 2NQOA 2K0NA 4BKEA 2XVQA 1BJ5A 5D7GA 3MHSB 2DBWA 1HK5A 2BXKA 3CX9A 5FUOA 3SIUB 2LQIA 2OT3A 3B9MA 2VUEA 3B9LA 2DYOA 4ZCGA 1MUSA 3G9KD 1KDXA 5IIUA 4FIPB 3NVIA 2BXIA 2BXDA 2XMOA 2GUTA 4N0FD 3KJLA 4PO0A 4S1YA 4Z9OA 5IJEA 1FOUA 4WA6B 5GIPA 1E7AA 2EFEA 1E7GA 4LB9A 2BXNA 5DQFA 4G01A 1TF0A 4F5SA 4IW2A 3WHQA
chains in the Genus database with same CATH topology
3LU8A 3V03A 4ZBKA 2VUFA 2BXPA 3GQUA 4HGMB 2XVWA 3FWCC 2DG5A 4ZUXV 5IJFA 2JUHA 2EFCA 2EFDA 2XW0A 4OTTA 2BX8A 4ZBQA 3PLAA 2BXAA 4GDLB 4E99A 1O9XA 3FNMA 4GG2A 2QMCA 4ZBRA 1E7FA 5IFOA 4BY9C 3NVKA 5GIOA 1HK3A 5GINA 1IJGA 4C31B 4GDXA 1KW2A 1HA2A 3FWBC 1H5WA 4TQ0A 2DBUA 4F5TA 4DHXB 1KXPD 2XVUA 3M99C 3H3AA 2ROHA 4OR0A 1NT2B 2NNWA 1LOTA 3GA9L 5BPKA 1HK4A 4G03A 2BXOA 4OT2A 5IJ5A 5GHKA 3SQJA 4L9KA 1J7EA 4J2VA 4NAWB 1H9ZA 3JQZA 2I30A 4LUFA 3NVMA 4GDKB 2CKXA 2BXMA 3GQXA 2YDFA 4FJCB 2V36A 1MIVA 3LU7A 1UORA 1JNBA 4ZC6A 2QHBA 4TQ1A 5IIHA 4W4UB 4G04A 2BXEA 4L8UA 3LU6A 4LB2A 4N0UD 1E7BA 2BXBA 4N3ZA 4OTUA 1E7IA 2LOQA 1MIYA 2BXQA 2QM6A 3JRYA 2BXCA 1N5UA 2E0XA 3A73A 4EMXA 1HK2A 3TDLA 4K2CA 2DBXA 3W1SA 1BM0A 2EFHA 2KBZA 2I2ZA 1AO6A 5DBYA 1E78A 3VQIA 1TXUA 1GNIA 5ID7A 4M70B 2E0YA 1LNSA 1MIWA 2Z8IA 3KIKA 4K71A 2BXLA 3MHHB 4MBEC 3SIVB 2Z8KA 1E7HA 1BKEA 3A75A 5B5TA 1HK1A 3H37A 4FK5B 1E7EA 4HGKA 4F5VA 2AJEA 1VFIA 4LA0A 5ID9A 3UIVA 5IIXA 2BXHA 2XW1A 4LUHA 3NMUA 1J78A 4Z69A 2Z8JA 3V09A 1MA9A 4L9QA 3V08A 4JK4A 1E7CA 2BXFA 2VDBA 2XSIA 4IW1A 2DYMA 5HOZA 3WHRA 4F5UA 2BXGA 1GNJA 1VZSA 2OZBB 3WHSA 3ICXA 2XVVA 2NQOA 4BKEA 2XVQA 1BJ5A 5D7GA 3MHSB 2DBWA 1HK5A 2BXKA 3CX9A 5FUOA 3SIUB 2OT3A 3B9MA 2VUEA 3B9LA 2DYOA 4ZCGA 3G9KD 5IIUA 4FIPB 3NVIA 2BXIA 2BXDA 2XMOA 4N0FD 3KJLA 4PO0A 4S1YA 4Z9OA 5IJEA 1FOUA 4WA6B 5GIPA 1E7AA 2EFEA 1E7GA 4LB9A 2BXNA 5DQFA 4G01A 1TF0A 4F5SA 4IW2A 3WHQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3LU8 A;  3V03 A;  2VUF A;  2BXP A;  4HGM B;  2XVW A;  5IJF A;  2XW0 A;  4ZBQ A;  2BX8 A;  2BXA A;  4E99 A;  1O9X A;  4ZBR A;  1E7F A;  5IFO A;  1HK3 A;  1KW2 A;  1HA2 A;  4F5T A;  1KXP D;  2XVU A;  4OR0 A;  1LOT A;  1HK4 A;  4G03 A;  2BXO A;  4OT2 A;  5IJ5 A;  5GHK A;  3SQJ A;  4L9K A;  1J7E A;  4J2V A;  1H9Z A;  3JQZ A;  2I30 A;  4LUF A;  2BXM A;  2YDF A;  3LU7 A;  1UOR A;  5IIH A;  4G04 A;  2BXE A;  4L8U A;  3LU6 A;  4LB2 A;  4N0U D;  1E7B A;  2BXB A;  1E7I A;  2BXQ A;  3JRY A;  2BXC A;  1N5U A;  3A73 A;  4EMX A;  1HK2 A;  3TDL A;  4K2C A;  1BM0 A;  2I2Z A;  1AO6 A;  5DBY A;  1E78 A;  5ID7 A;  1GNI A;  4K71 A;  2BXL A;  1E7H A;  1BKE A;  1HK1 A;  5ID9 A;  1E7E A;  4HGK A;  4F5V A;  4LA0 A;  5IIX A;  3UIV A;  2BXH A;  2XW1 A;  4LUH A;  1J78 A;  4Z69 A;  3V09 A;  1MA9 A;  4L9Q A;  3V08 A;  4JK4 A;  1E7C A;  2BXF A;  4IW1 A;  2XSI A;  2VDB A;  5HOZ A;  4F5U A;  2BXG A;  1GNJ A;  2XVV A;  4BKE A;  2XVQ A;  1BJ5 A;  1HK5 A;  2BXK A;  3CX9 A;  5FUO A;  3B9M A;  2VUE A;  3B9L A;  5IIU A;  2BXI A;  2BXD A;  4N0F D;  4PO0 A;  4S1Y A;  5IJE A;  1E7A A;  1E7G A;  4LB9 A;  2BXN A;  5DQF A;  1TF0 A;  4F5S A;  4IW2 A; 
#chains in the Genus database with same CATH topology
 2AGH B;  3LU8 A;  4DM0 A;  3V03 A;  4ZBK A;  2VUF A;  2BXP A;  3GQU A;  4HGM B;  2XVW A;  3FWC C;  2DG5 A;  4ZUX V;  5IJF A;  2KWF A;  2JUH A;  2EFC A;  2EFD A;  2XW0 A;  4OTT A;  2BX8 A;  4ZBQ A;  3PLA A;  2BXA A;  4GDL B;  4E99 A;  1O9X A;  3FNM A;  4GG2 A;  2QMC A;  4ZBR A;  1E7F A;  5IFO A;  4BY9 C;  3NVK A;  5GIO A;  1HK3 A;  5GIN A;  1IJG A;  4C31 B;  4GDX A;  1KW2 A;  1HA2 A;  3FWB C;  1H5W A;  4TQ0 A;  2DBU A;  4F5T A;  4DHX B;  1KXP D;  2XVU A;  4I9O A;  3M99 C;  3H3A A;  2ROH A;  4OR0 A;  3ECP A;  1NT2 B;  2NNW A;  1LOT A;  3GA9 L;  5BPK A;  1HK4 A;  4G03 A;  2BXO A;  4OT2 A;  5IJ5 A;  5GHK A;  3SQJ A;  4L9K A;  1J7E A;  4J2V A;  4NAW B;  1H9Z A;  3BPJ A;  3JQZ A;  2I30 A;  4LUF A;  1SB0 A;  3NVM A;  4GDK B;  2CKX A;  2BXM A;  3GQX A;  2YDF A;  4FJC B;  2V36 A;  1MIV A;  3LU7 A;  1UOR A;  1JNB A;  4ZC6 A;  2QHB A;  4TQ1 A;  5IIH A;  4W4U B;  4G04 A;  2LXT A;  2BXE A;  1MUH A;  4L8U A;  3LU6 A;  4LB2 A;  4N0U D;  1E7B A;  2BXB A;  4N3Z A;  4OTU A;  1E7I A;  2LOQ A;  1MIY A;  2BXQ A;  2QM6 A;  3JRY A;  2BXC A;  1N5U A;  2E0X A;  3A73 A;  4EMX A;  1HK2 A;  3TDL A;  4K2C A;  2DBX A;  3W1S A;  1BM0 A;  2EFH A;  2KBZ A;  2I2Z A;  1AO6 A;  5DBY A;  1E78 A;  3VQI A;  1TXU A;  1GNI A;  5ID7 A;  4D7X A;  4M70 B;  2E0Y A;  1LNS A;  1MIW A;  2Z8I A;  3KIK A;  4K71 A;  2BXL A;  3MHH B;  4MBE C;  3SIV B;  2Z8K A;  1E7H A;  1BKE A;  3A75 A;  5B5T A;  1HK1 A;  3H37 A;  4FK5 B;  1E7E A;  4HGK A;  4F5V A;  2AJE A;  1VFI A;  4LA0 A;  5ID9 A;  3UIV A;  5IIX A;  2BXH A;  2XW1 A;  4LUH A;  3NMU A;  1J78 A;  4Z69 A;  2Z8J A;  3V09 A;  1MA9 A;  2LXS A;  4L9Q A;  3V08 A;  4JK4 A;  1E7C A;  2BXF A;  2VDB A;  2XSI A;  4IW1 A;  2DYM A;  1MM8 A;  5HOZ A;  3WHR A;  4F5U A;  2BXG A;  1GNJ A;  1VZS A;  2LQH A;  2OZB B;  3WHS A;  3ICX A;  2XVV A;  2NQO A;  2K0N A;  4BKE A;  2XVQ A;  1BJ5 A;  5D7G A;  3MHS B;  2DBW A;  1HK5 A;  2BXK A;  3CX9 A;  5FUO A;  3SIU B;  2LQI A;  2OT3 A;  3B9M A;  2VUE A;  3B9L A;  2DYO A;  4ZCG A;  1MUS A;  3G9K D;  1KDX A;  5IIU A;  4FIP B;  3NVI A;  2BXI A;  2BXD A;  2XMO A;  2GUT A;  4N0F D;  3KJL A;  4PO0 A;  4S1Y A;  4Z9O A;  5IJE A;  1FOU A;  4WA6 B;  5GIP A;  1E7A A;  2EFE A;  1E7G A;  4LB9 A;  2BXN A;  5DQF A;  4G01 A;  1TF0 A;  4F5S A;  4IW2 A;  3WHQ A; 
#chains in the Genus database with same CATH homology
 3LU8 A;  3V03 A;  4ZBK A;  2VUF A;  2BXP A;  3GQU A;  4HGM B;  2XVW A;  3FWC C;  2DG5 A;  4ZUX V;  5IJF A;  2JUH A;  2EFC A;  2EFD A;  2XW0 A;  4OTT A;  2BX8 A;  4ZBQ A;  3PLA A;  2BXA A;  4GDL B;  4E99 A;  1O9X A;  3FNM A;  4GG2 A;  2QMC A;  4ZBR A;  1E7F A;  5IFO A;  4BY9 C;  3NVK A;  5GIO A;  1HK3 A;  5GIN A;  1IJG A;  4C31 B;  4GDX A;  1KW2 A;  1HA2 A;  3FWB C;  1H5W A;  4TQ0 A;  2DBU A;  4F5T A;  4DHX B;  1KXP D;  2XVU A;  3M99 C;  3H3A A;  2ROH A;  4OR0 A;  1NT2 B;  2NNW A;  1LOT A;  3GA9 L;  5BPK A;  1HK4 A;  4G03 A;  2BXO A;  4OT2 A;  5IJ5 A;  5GHK A;  3SQJ A;  4L9K A;  1J7E A;  4J2V A;  4NAW B;  1H9Z A;  3JQZ A;  2I30 A;  4LUF A;  3NVM A;  4GDK B;  2CKX A;  2BXM A;  3GQX A;  2YDF A;  4FJC B;  2V36 A;  1MIV A;  3LU7 A;  1UOR A;  1JNB A;  4ZC6 A;  2QHB A;  4TQ1 A;  5IIH A;  4W4U B;  4G04 A;  2BXE A;  4L8U A;  3LU6 A;  4LB2 A;  4N0U D;  1E7B A;  2BXB A;  4N3Z A;  4OTU A;  1E7I A;  2LOQ A;  1MIY A;  2BXQ A;  2QM6 A;  3JRY A;  2BXC A;  1N5U A;  2E0X A;  3A73 A;  4EMX A;  1HK2 A;  3TDL A;  4K2C A;  2DBX A;  3W1S A;  1BM0 A;  2EFH A;  2KBZ A;  2I2Z A;  1AO6 A;  5DBY A;  1E78 A;  3VQI A;  1TXU A;  1GNI A;  5ID7 A;  4M70 B;  2E0Y A;  1LNS A;  1MIW A;  2Z8I A;  3KIK A;  4K71 A;  2BXL A;  3MHH B;  4MBE C;  3SIV B;  2Z8K A;  1E7H A;  1BKE A;  3A75 A;  5B5T A;  1HK1 A;  3H37 A;  4FK5 B;  1E7E A;  4HGK A;  4F5V A;  2AJE A;  1VFI A;  4LA0 A;  5ID9 A;  3UIV A;  5IIX A;  2BXH A;  2XW1 A;  4LUH A;  3NMU A;  1J78 A;  4Z69 A;  2Z8J A;  3V09 A;  1MA9 A;  4L9Q A;  3V08 A;  4JK4 A;  1E7C A;  2BXF A;  2VDB A;  2XSI A;  4IW1 A;  2DYM A;  5HOZ A;  3WHR A;  4F5U A;  2BXG A;  1GNJ A;  1VZS A;  2OZB B;  3WHS A;  3ICX A;  2XVV A;  2NQO A;  4BKE A;  2XVQ A;  1BJ5 A;  5D7G A;  3MHS B;  2DBW A;  1HK5 A;  2BXK A;  3CX9 A;  5FUO A;  3SIU B;  2OT3 A;  3B9M A;  2VUE A;  3B9L A;  2DYO A;  4ZCG A;  3G9K D;  5IIU A;  4FIP B;  3NVI A;  2BXI A;  2BXD A;  2XMO A;  4N0F D;  3KJL A;  4PO0 A;  4S1Y A;  4Z9O A;  5IJE A;  1FOU A;  4WA6 B;  5GIP A;  1E7A A;  2EFE A;  1E7G A;  4LB9 A;  2BXN A;  5DQF A;  4G01 A;  1TF0 A;  4F5S A;  4IW2 A;  3WHQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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