3JQZA

Crystal structure of human serum albumin complexed with lidocaine
Total Genus 185
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
185
sequence length
582
structure length
582
Chain Sequence
DAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Serum albumin
publication title Crystallographic analysis reveals a unique lidocaine binding site on human serum albumin.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transport protein
total genus 185
structure length 582
sequence length 582
chains with identical sequence B
ec nomenclature
pdb deposition date 2009-09-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 3jqzA03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 3jqzA02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 3jqzA04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 3jqzA01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 3jqzA06
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 3jqzA05
1HK4A 4ZBRA 5IIHA 1E7GA 4N0UD 2XVUA 3V08A 2YDFA 3SQJA 5HOZA 2BXGA 1HA2A 5DQFA 4LB9A 4LUFA 4L9QA 5IIXA 1E7CA 1E7AA 1HK2A 1TF0A 2BXQA 2BXLA 1E7IA 2BXNA 3LU7A 4G04A 2BXKA 3B9MA 2BXEA 4OT2A 2XVVA 4K2CA 3LU6A 2BXOA 1HK1A 5ID9A 4PO0A 2BXAA 4L9KA 5IJ5A 1GNIA 4ZBQA 2VDBA 2XW0A 4BKEA 5DBYA 4IW2A 2BXPA 4LB2A 5IJFA 4L8UA 1E78A 3V03A 4E99A 4S1YA 2XVWA 1O9XA 5GHKA 4K71A 4OR0A 5IJEA 2BXIA 3TDLA 4F5TA 1BM0A 1HK5A 2XVQA 4F5UA 2VUFA 4IW1A 1GNJA 1E7FA 3LU8A 1BKEA 4EMXA 2BXMA 4LA0A 3V09A 1KXPD 1E7BA 4HGMB 1KW2A 4JK4A 2BX8A 2XSIA 4G03A 1J7EA 2XW1A 1H9ZA 2BXHA 3A73A 5IIUA 1MA9A 3B9LA 5ID7A 1AO6A 4HGKA 4N0FD 2BXBA 1E7HA 1N5UA 2I30A 1HK3A 2VUEA 3JRYA 4LUHA 1BJ5A 1E7EA 2BXDA 2BXFA 5IFOA 3CX9A 4Z69A 2BXCA 1J78A 3UIVA 4J2VA 4F5VA 3JQZA 2I2ZA 5FUOA 1LOTA 1UORA 4F5SA
chains in the Genus database with same CATH superfamily
1HK4A 1NT2B 4ZBRA 5IIHA 1E7GA 4N0UD 2XVUA 3A75A 2ROHA 3V08A 2EFEA 3MHSB 2OZBB 2YDFA 3SQJA 3MHHB 1MUSA 2DBUA 5HOZA 2BXGA 1HA2A 2KWFA 5DQFA 4LB9A 2LXTA 3GA9L 4FIPB 4TQ0A 4LUFA 4L9QA 5IIXA 1E7CA 4OTTA 1E7AA 1HK2A 2E0YA 1TF0A 2XMOA 4DM0A 3W1SA 2BXQA 2BXLA 1E7IA 1JNBA 2BXNA 4MBEC 2DYOA 3LU7A 4G04A 2BXKA 3B9MA 3G9KD 2BXEA 4OT2A 2XVVA 4K2CA 3LU6A 2BXOA 1HK1A 5ID9A 2EFCA 4M70B 2QMCA 4PO0A 2BXAA 4L9KA 2LXSA 5GIOA 5IJ5A 1GNIA 4ZBQA 4GDKB 2OT3A 2VDBA 2XW0A 1MUHA 4BKEA 3NVIA 5GINA 2DBXA 2CKXA 5DBYA 3FWBC 4IW2A 2BXPA 1VFIA 5B5TA 4LB2A 3ICXA 4ZUXV 3ECPA 5IJFA 4TQ1A 4L8UA 1IJGA 3NVMA 1E78A 4D7XA 3V03A 4GDLB 3VQIA 2EFDA 4S1YA 4E99A 2XVWA 1O9XA 2NNWA 4ZBKA 4K71A 2DYMA 2K0NA 5GHKA 2AGHB 1FOUA 3KIKA 3PLAA 2V36A 4OR0A 5IJEA 2BXIA 3SIUB 3TDLA 4F5TA 2QHBA 2Z8JA 2LOQA 1BM0A 1HK5A 2JUHA 2XVQA 4OTUA 4I9OA 3WHRA 2QM6A 4ZCGA 4F5UA 3KJLA 2VUFA 3GQUA 4IW1A 5GIPA 1GNJA 1E7FA 4FK5B 2EFHA 2KBZA 3LU8A 1BKEA 4EMXA 2BXMA 4LA0A 3V09A 1KXPD 1E7BA 4HGMB 3BPJA 1KW2A 4JK4A 2BX8A 3NMUA 2XSIA 2LQIA 1J7EA 2NQOA 2XW1A 3GQXA 3H37A 4G01A 2AJEA 1MIWA 3H3AA 1H9ZA 2BXHA 3A73A 5IIUA 1MA9A 3B9LA 4FJCB 5ID7A 1SB0A 1AO6A 4GDXA 4HGKA 4N0FD 4GG2A 2BXBA 5D7GA 1MM8A 3M99C 1MIVA 1E7HA 1N5UA 2GUTA 4NAWB 2I30A 3WHQA 1HK3A 1H5WA 2VUEA 4G03A 4N3ZA 3JRYA 5BPKA 4WA6B 3FWCC 4LUHA 1BJ5A 1E7EA 3FNMA 4C31B 2BXDA 4Z9OA 1KDXA 4ZC6A 2BXFA 5IFOA 3NVKA 2DG5A 3CX9A 4Z69A 3SIVB 1TXUA 2BXCA 1J78A 1VZSA 3UIVA 4J2VA 2E0XA 2DBWA 4F5VA 2LQHA 4W4UB 1LNSA 4BY9C 3JQZA 2Z8IA 4DHXB 2I2ZA 1MIYA 2Z8KA 3WHSA 1LOTA 5FUOA 1UORA 4F5SA
chains in the Genus database with same CATH topology
1HK4A 1NT2B 4ZBRA 5IIHA 1E7GA 4N0UD 2XVUA 3A75A 2ROHA 3V08A 2EFEA 3MHSB 2OZBB 2YDFA 3SQJA 3MHHB 2DBUA 5HOZA 2BXGA 1HA2A 5DQFA 4LB9A 4TQ0A 3GA9L 4FIPB 4LUFA 4L9QA 5IIXA 1E7CA 4OTTA 1E7AA 1HK2A 2E0YA 1TF0A 2XMOA 3W1SA 2BXQA 2BXLA 1E7IA 1JNBA 2BXNA 4MBEC 2DYOA 3LU7A 4G04A 2BXKA 3B9MA 3G9KD 2BXEA 4OT2A 2XVVA 4K2CA 3LU6A 2BXOA 1HK1A 5ID9A 2EFCA 4M70B 2QMCA 4PO0A 2BXAA 4L9KA 5GIOA 5IJ5A 1GNIA 4ZBQA 4GDKB 2OT3A 2VDBA 2XW0A 4BKEA 3NVIA 5GINA 2DBXA 2CKXA 5DBYA 3FWBC 4IW2A 2BXPA 1VFIA 5B5TA 4LB2A 3ICXA 4ZUXV 5IJFA 4TQ1A 4L8UA 1IJGA 3NVMA 1E78A 3V03A 4GDLB 3VQIA 2EFDA 4S1YA 4E99A 2XVWA 1O9XA 2NNWA 4ZBKA 4K71A 2DYMA 5GHKA 1FOUA 3KIKA 3PLAA 2V36A 4OR0A 5IJEA 2BXIA 3SIUB 3TDLA 4F5TA 2QHBA 2Z8JA 2LOQA 1BM0A 1HK5A 2JUHA 2XVQA 4OTUA 3WHRA 2QM6A 4ZCGA 4F5UA 3KJLA 2VUFA 3GQUA 4IW1A 5GIPA 1GNJA 1E7FA 4FK5B 2EFHA 2KBZA 3LU8A 1BKEA 4EMXA 2BXMA 4LA0A 3V09A 1KXPD 1E7BA 4HGMB 1KW2A 4JK4A 2BX8A 3NMUA 2XSIA 4G03A 1J7EA 2NQOA 2XW1A 3GQXA 3H37A 4G01A 2AJEA 1MIWA 3H3AA 1H9ZA 2BXHA 3A73A 5IIUA 1MA9A 3B9LA 4FJCB 5ID7A 1AO6A 4GDXA 4HGKA 4N0FD 4GG2A 2BXBA 5D7GA 3M99C 1MIVA 1E7HA 1N5UA 4NAWB 2I30A 3WHQA 1HK3A 1H5WA 2VUEA 4N3ZA 3JRYA 5BPKA 4WA6B 3FWCC 4LUHA 1BJ5A 1E7EA 3FNMA 4C31B 2BXDA 4Z9OA 4ZC6A 2BXFA 5IFOA 3NVKA 2DG5A 3CX9A 4Z69A 3SIVB 1TXUA 2BXCA 1J78A 1VZSA 3UIVA 4J2VA 2E0XA 2DBWA 4F5VA 4W4UB 1LNSA 4BY9C 3JQZA 2Z8IA 4DHXB 2I2ZA 1MIYA 2Z8KA 3WHSA 1LOTA 5FUOA 1UORA 4F5SA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1HK4 A;  4ZBR A;  5IIH A;  1E7G A;  4N0U D;  2XVU A;  3V08 A;  2YDF A;  3SQJ A;  5HOZ A;  2BXG A;  1HA2 A;  5DQF A;  4LB9 A;  4LUF A;  4L9Q A;  5IIX A;  1E7C A;  1E7A A;  1HK2 A;  1TF0 A;  2BXQ A;  2BXL A;  1E7I A;  2BXN A;  3LU7 A;  4G04 A;  2BXK A;  3B9M A;  2BXE A;  4OT2 A;  2XVV A;  4K2C A;  3LU6 A;  2BXO A;  1HK1 A;  5ID9 A;  4PO0 A;  2BXA A;  4L9K A;  5IJ5 A;  1GNI A;  4ZBQ A;  2VDB A;  2XW0 A;  4BKE A;  5DBY A;  4IW2 A;  2BXP A;  4LB2 A;  5IJF A;  4L8U A;  1E78 A;  3V03 A;  4E99 A;  4S1Y A;  2XVW A;  1O9X A;  5GHK A;  4K71 A;  4OR0 A;  5IJE A;  2BXI A;  3TDL A;  4F5T A;  1BM0 A;  1HK5 A;  2XVQ A;  4F5U A;  2VUF A;  4IW1 A;  1GNJ A;  1E7F A;  3LU8 A;  1BKE A;  4EMX A;  2BXM A;  4LA0 A;  3V09 A;  1KXP D;  1E7B A;  4HGM B;  1KW2 A;  4JK4 A;  2BX8 A;  2XSI A;  4G03 A;  1J7E A;  2XW1 A;  1H9Z A;  2BXH A;  3A73 A;  5IIU A;  1MA9 A;  3B9L A;  5ID7 A;  1AO6 A;  4HGK A;  4N0F D;  2BXB A;  1E7H A;  1N5U A;  2I30 A;  1HK3 A;  2VUE A;  3JRY A;  4LUH A;  1BJ5 A;  1E7E A;  2BXD A;  2BXF A;  5IFO A;  3CX9 A;  4Z69 A;  2BXC A;  1J78 A;  3UIV A;  4J2V A;  4F5V A;  3JQZ A;  2I2Z A;  5FUO A;  1LOT A;  1UOR A;  4F5S A; 
#chains in the Genus database with same CATH topology
 1HK4 A;  1NT2 B;  4ZBR A;  5IIH A;  1E7G A;  4N0U D;  2XVU A;  3A75 A;  2ROH A;  3V08 A;  2EFE A;  3MHS B;  2OZB B;  2YDF A;  3SQJ A;  3MHH B;  1MUS A;  2DBU A;  5HOZ A;  2BXG A;  1HA2 A;  2KWF A;  5DQF A;  4LB9 A;  2LXT A;  3GA9 L;  4FIP B;  4TQ0 A;  4LUF A;  4L9Q A;  5IIX A;  1E7C A;  4OTT A;  1E7A A;  1HK2 A;  2E0Y A;  1TF0 A;  2XMO A;  4DM0 A;  3W1S A;  2BXQ A;  2BXL A;  1E7I A;  1JNB A;  2BXN A;  4MBE C;  2DYO A;  3LU7 A;  4G04 A;  2BXK A;  3B9M A;  3G9K D;  2BXE A;  4OT2 A;  2XVV A;  4K2C A;  3LU6 A;  2BXO A;  1HK1 A;  5ID9 A;  2EFC A;  4M70 B;  2QMC A;  4PO0 A;  2BXA A;  4L9K A;  2LXS A;  5GIO A;  5IJ5 A;  1GNI A;  4ZBQ A;  4GDK B;  2OT3 A;  2VDB A;  2XW0 A;  1MUH A;  4BKE A;  3NVI A;  5GIN A;  2DBX A;  2CKX A;  5DBY A;  3FWB C;  4IW2 A;  2BXP A;  1VFI A;  5B5T A;  4LB2 A;  3ICX A;  4ZUX V;  3ECP A;  5IJF A;  4TQ1 A;  4L8U A;  1IJG A;  3NVM A;  1E78 A;  4D7X A;  3V03 A;  4GDL B;  3VQI A;  2EFD A;  4S1Y A;  4E99 A;  2XVW A;  1O9X A;  2NNW A;  4ZBK A;  4K71 A;  2DYM A;  2K0N A;  5GHK A;  2AGH B;  1FOU A;  3KIK A;  3PLA A;  2V36 A;  4OR0 A;  5IJE A;  2BXI A;  3SIU B;  3TDL A;  4F5T A;  2QHB A;  2Z8J A;  2LOQ A;  1BM0 A;  1HK5 A;  2JUH A;  2XVQ A;  4OTU A;  4I9O A;  3WHR A;  2QM6 A;  4ZCG A;  4F5U A;  3KJL A;  2VUF A;  3GQU A;  4IW1 A;  5GIP A;  1GNJ A;  1E7F A;  4FK5 B;  2EFH A;  2KBZ A;  3LU8 A;  1BKE A;  4EMX A;  2BXM A;  4LA0 A;  3V09 A;  1KXP D;  1E7B A;  4HGM B;  3BPJ A;  1KW2 A;  4JK4 A;  2BX8 A;  3NMU A;  2XSI A;  2LQI A;  1J7E A;  2NQO A;  2XW1 A;  3GQX A;  3H37 A;  4G01 A;  2AJE A;  1MIW A;  3H3A A;  1H9Z A;  2BXH A;  3A73 A;  5IIU A;  1MA9 A;  3B9L A;  4FJC B;  5ID7 A;  1SB0 A;  1AO6 A;  4GDX A;  4HGK A;  4N0F D;  4GG2 A;  2BXB A;  5D7G A;  1MM8 A;  3M99 C;  1MIV A;  1E7H A;  1N5U A;  2GUT A;  4NAW B;  2I30 A;  3WHQ A;  1HK3 A;  1H5W A;  2VUE A;  4G03 A;  4N3Z A;  3JRY A;  5BPK A;  4WA6 B;  3FWC C;  4LUH A;  1BJ5 A;  1E7E A;  3FNM A;  4C31 B;  2BXD A;  4Z9O A;  1KDX A;  4ZC6 A;  2BXF A;  5IFO A;  3NVK A;  2DG5 A;  3CX9 A;  4Z69 A;  3SIV B;  1TXU A;  2BXC A;  1J78 A;  1VZS A;  3UIV A;  4J2V A;  2E0X A;  2DBW A;  4F5V A;  2LQH A;  4W4U B;  1LNS A;  4BY9 C;  3JQZ A;  2Z8I A;  4DHX B;  2I2Z A;  1MIY A;  2Z8K A;  3WHS A;  1LOT A;  5FUO A;  1UOR A;  4F5S A; 
#chains in the Genus database with same CATH homology
 1HK4 A;  1NT2 B;  4ZBR A;  5IIH A;  1E7G A;  4N0U D;  2XVU A;  3A75 A;  2ROH A;  3V08 A;  2EFE A;  3MHS B;  2OZB B;  2YDF A;  3SQJ A;  3MHH B;  2DBU A;  5HOZ A;  2BXG A;  1HA2 A;  5DQF A;  4LB9 A;  4TQ0 A;  3GA9 L;  4FIP B;  4LUF A;  4L9Q A;  5IIX A;  1E7C A;  4OTT A;  1E7A A;  1HK2 A;  2E0Y A;  1TF0 A;  2XMO A;  3W1S A;  2BXQ A;  2BXL A;  1E7I A;  1JNB A;  2BXN A;  4MBE C;  2DYO A;  3LU7 A;  4G04 A;  2BXK A;  3B9M A;  3G9K D;  2BXE A;  4OT2 A;  2XVV A;  4K2C A;  3LU6 A;  2BXO A;  1HK1 A;  5ID9 A;  2EFC A;  4M70 B;  2QMC A;  4PO0 A;  2BXA A;  4L9K A;  5GIO A;  5IJ5 A;  1GNI A;  4ZBQ A;  4GDK B;  2OT3 A;  2VDB A;  2XW0 A;  4BKE A;  3NVI A;  5GIN A;  2DBX A;  2CKX A;  5DBY A;  3FWB C;  4IW2 A;  2BXP A;  1VFI A;  5B5T A;  4LB2 A;  3ICX A;  4ZUX V;  5IJF A;  4TQ1 A;  4L8U A;  1IJG A;  3NVM A;  1E78 A;  3V03 A;  4GDL B;  3VQI A;  2EFD A;  4S1Y A;  4E99 A;  2XVW A;  1O9X A;  2NNW A;  4ZBK A;  4K71 A;  2DYM A;  5GHK A;  1FOU A;  3KIK A;  3PLA A;  2V36 A;  4OR0 A;  5IJE A;  2BXI A;  3SIU B;  3TDL A;  4F5T A;  2QHB A;  2Z8J A;  2LOQ A;  1BM0 A;  1HK5 A;  2JUH A;  2XVQ A;  4OTU A;  3WHR A;  2QM6 A;  4ZCG A;  4F5U A;  3KJL A;  2VUF A;  3GQU A;  4IW1 A;  5GIP A;  1GNJ A;  1E7F A;  4FK5 B;  2EFH A;  2KBZ A;  3LU8 A;  1BKE A;  4EMX A;  2BXM A;  4LA0 A;  3V09 A;  1KXP D;  1E7B A;  4HGM B;  1KW2 A;  4JK4 A;  2BX8 A;  3NMU A;  2XSI A;  4G03 A;  1J7E A;  2NQO A;  2XW1 A;  3GQX A;  3H37 A;  4G01 A;  2AJE A;  1MIW A;  3H3A A;  1H9Z A;  2BXH A;  3A73 A;  5IIU A;  1MA9 A;  3B9L A;  4FJC B;  5ID7 A;  1AO6 A;  4GDX A;  4HGK A;  4N0F D;  4GG2 A;  2BXB A;  5D7G A;  3M99 C;  1MIV A;  1E7H A;  1N5U A;  4NAW B;  2I30 A;  3WHQ A;  1HK3 A;  1H5W A;  2VUE A;  4N3Z A;  3JRY A;  5BPK A;  4WA6 B;  3FWC C;  4LUH A;  1BJ5 A;  1E7E A;  3FNM A;  4C31 B;  2BXD A;  4Z9O A;  4ZC6 A;  2BXF A;  5IFO A;  3NVK A;  2DG5 A;  3CX9 A;  4Z69 A;  3SIV B;  1TXU A;  2BXC A;  1J78 A;  1VZS A;  3UIV A;  4J2V A;  2E0X A;  2DBW A;  4F5V A;  4W4U B;  1LNS A;  4BY9 C;  3JQZ A;  2Z8I A;  4DHX B;  2I2Z A;  1MIY A;  2Z8K A;  3WHS A;  1LOT A;  5FUO A;  1UOR A;  4F5S A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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