1E7BA

Crystal structure of human serum albumin complexed with the general anesthetic halothane
Total Genus 197
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
197
sequence length
578
structure length
578
Chain Sequence
SEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Binding of the General Anesthetics Propofol and Halothane to Human Serum Albumin. High Resolution Crystal Structures
pubmed doi rcsb
molecule tags Carrier protein
source organism Homo sapiens
molecule keywords SERUM ALBUMIN
total genus 197
structure length 578
sequence length 578
chains with identical sequence B
ec nomenclature
pdb deposition date 2000-08-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7bA03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7bA02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7bA04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7bA01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7bA06
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7bA05
5IJ5A 2BXAA 1E7GA 4IW2A 4JK4A 2BXNA 3LU6A 1E7FA 2BXPA 3A73A 2XW0A 4L9KA 2BXLA 3B9MA 4HGMB 3UIVA 2XVUA 2BXHA 2BXBA 3JQZA 4IW1A 2XVVA 2XSIA 3LU7A 1HK4A 5IFOA 1HK3A 4E99A 1BM0A 2XVQA 4Z69A 1HK1A 1O9XA 1GNJA 4LUFA 4LB9A 2BXKA 4J2VA 2YDFA 4BKEA 5HOZA 2BXOA 3V09A 1AO6A 4N0FD 1N5UA 1E78A 4L8UA 1E7CA 5FUOA 4ZBQA 2BX8A 1J7EA 1E7AA 1KW2A 2XW1A 4S1YA 4LA0A 2BXMA 5IJFA 1E7BA 1E7EA 2I30A 4N0UD 2BXIA 4PO0A 4F5TA 3V08A 2BXEA 4LB2A 5DQFA 1E7HA 5ID7A 4F5UA 4K71A 3V03A 5IIXA 1HK2A 2BXGA 1E7IA 4L9QA 2BXCA 3CX9A 1J78A 1TF0A 4G03A 4LUHA 5IIUA 4HGKA 4G04A 2XVWA 2BXDA 1UORA 2VDBA 4EMXA 4K2CA 3LU8A 2VUFA 1LOTA 2BXFA 5GHKA 5IJEA 1H9ZA 1BJ5A 1HK5A 4OT2A 1MA9A 5DBYA 1KXPD 1HA2A 1GNIA 2I2ZA 3B9LA 3JRYA 4ZBRA 4F5VA 5ID9A 1BKEA 5IIHA 3TDLA 2VUEA 2BXQA 4OR0A 4F5SA 3SQJA
chains in the Genus database with same CATH superfamily
5IJ5A 2BXAA 4W4UB 5GIPA 1E7GA 4IW2A 2DBUA 1H5WA 2E0YA 5B5TA 2QM6A 4JK4A 1SB0A 4G01A 2BXNA 3LU6A 3W1SA 1E7FA 2BXPA 3A73A 4N3ZA 3MHHB 2XW0A 2E0XA 4L9KA 4BY9C 4OTTA 3G9KD 2BXLA 3B9MA 4HGMB 3UIVA 3NVKA 2XMOA 2XVUA 3ECPA 2BXHA 2BXBA 3GQXA 3JQZA 4IW1A 2KBZA 2XVVA 4D7XA 2XSIA 2AGHB 1HK4A 3LU7A 1HK3A 5IFOA 4E99A 3A75A 3NMUA 3WHRA 1BM0A 1NT2B 4NAWB 1MM8A 2XVQA 3KJLA 3SIVB 4Z69A 1HK1A 2LXTA 4MBEC 1O9XA 3FWBC 2EFDA 1MUSA 4TQ1A 1GNJA 2DBWA 4GDKB 2DG5A 4LB9A 4LUFA 2BXKA 4J2VA 2YDFA 4BKEA 5HOZA 2BXOA 3V09A 3WHQA 2KWFA 1AO6A 4N0FD 1N5UA 1E78A 2EFEA 4OTUA 2DYOA 4ZCGA 4L8UA 3NVIA 1E7CA 5FUOA 1IJGA 4ZBQA 5GIOA 2BX8A 3SIUB 1J7EA 1E7AA 1KW2A 2XW1A 4ZC6A 4GG2A 4S1YA 4LA0A 2BXMA 5IJFA 1E7BA 1E7EA 3BPJA 2ROHA 2I30A 4C31B 4I9OA 2V36A 4DHXB 4N0UD 2BXIA 4PO0A 4F5TA 3V08A 2BXEA 1MUHA 4LB2A 5DQFA 1E7HA 5ID7A 4F5UA 4K71A 3V03A 2LQIA 5IIXA 3KIKA 1HK2A 4FIPB 1KDXA 2BXGA 3MHSB 1E7IA 4Z9OA 4WA6B 3FWCC 4L9QA 2QMCA 2BXCA 1MIWA 2Z8IA 2EFHA 1FOUA 2DBXA 3CX9A 1J78A 3M99C 1TF0A 2Z8JA 2OT3A 4G03A 4LUHA 5IIUA 4HGKA 4G04A 2XVWA 4ZBKA 2BXDA 2QHBA 1UORA 4FK5B 2NQOA 2VDBA 4EMXA 1MIVA 2Z8KA 2NNWA 3H3AA 3LU8A 4FJCB 4K2CA 1TXUA 5BPKA 2LOQA 2VUFA 4GDXA 1VFIA 1LOTA 2BXFA 4TQ0A 5GINA 5GHKA 5IJEA 2AJEA 1H9ZA 1MIYA 3VQIA 3PLAA 1BJ5A 4GDLB 1HK5A 4OT2A 4DM0A 1MA9A 5DBYA 3WHSA 2EFCA 1KXPD 1LNSA 1HA2A 2LQHA 3GQUA 3FNMA 1GNIA 2DYMA 2I2ZA 1VZSA 3B9LA 3JRYA 4M70B 5D7GA 3ICXA 2OZBB 4ZBRA 4F5VA 5ID9A 3GA9L 4ZUXV 2JUHA 1BKEA 3NVMA 2LXSA 5IIHA 3H37A 2CKXA 3TDLA 2VUEA 2BXQA 4OR0A 4F5SA 2GUTA 2K0NA 3SQJA 1JNBA
chains in the Genus database with same CATH topology
5IJ5A 2BXAA 4W4UB 5GIPA 1E7GA 4IW2A 2DBUA 1H5WA 2E0YA 5B5TA 2QM6A 4JK4A 4G01A 2BXNA 3LU6A 3W1SA 1E7FA 2BXPA 3A73A 4N3ZA 3MHHB 2XW0A 2E0XA 4L9KA 4BY9C 4OTTA 3G9KD 2BXLA 3B9MA 4HGMB 3UIVA 3NVKA 2XMOA 2XVUA 2BXHA 2BXBA 3GQXA 3JQZA 4IW1A 2KBZA 2XVVA 2XSIA 3LU7A 1HK4A 5IFOA 1HK3A 4E99A 3A75A 3NMUA 3WHRA 1BM0A 1NT2B 4NAWB 2XVQA 3KJLA 3SIVB 4Z69A 1HK1A 4MBEC 1O9XA 3FWBC 2EFDA 4TQ1A 1GNJA 2DBWA 4GDKB 2DG5A 4LB9A 4LUFA 2BXKA 4J2VA 2YDFA 4BKEA 5HOZA 2BXOA 3V09A 3WHQA 1AO6A 4N0FD 1N5UA 1E78A 2EFEA 4OTUA 2DYOA 4ZCGA 4L8UA 3NVIA 1E7CA 5FUOA 1IJGA 4ZBQA 5GIOA 2BX8A 3SIUB 1J7EA 1E7AA 1KW2A 2XW1A 4ZC6A 4GG2A 4S1YA 4LA0A 2BXMA 5IJFA 1E7BA 1E7EA 2ROHA 2I30A 4C31B 2V36A 4DHXB 4N0UD 2BXIA 4PO0A 4F5TA 3V08A 2BXEA 4LB2A 5DQFA 1E7HA 5ID7A 4F5UA 4K71A 3V03A 5IIXA 3KIKA 1HK2A 4FIPB 2BXGA 3MHSB 1E7IA 4Z9OA 4WA6B 3FWCC 4L9QA 2QMCA 2BXCA 1MIWA 2Z8IA 2EFHA 1FOUA 2DBXA 3CX9A 1J78A 3M99C 1TF0A 2Z8JA 2OT3A 4G03A 4LUHA 5IIUA 4HGKA 4G04A 2XVWA 4ZBKA 2BXDA 2QHBA 1UORA 4FK5B 2NQOA 2VDBA 4EMXA 1MIVA 2Z8KA 2NNWA 3H3AA 3LU8A 4FJCB 4K2CA 1TXUA 5BPKA 2LOQA 2VUFA 4GDXA 1VFIA 1LOTA 2BXFA 4TQ0A 5GINA 5GHKA 5IJEA 2AJEA 1H9ZA 1MIYA 3VQIA 3PLAA 1BJ5A 4GDLB 1HK5A 4OT2A 1MA9A 5DBYA 3WHSA 2EFCA 1KXPD 1LNSA 1HA2A 3GQUA 3FNMA 1GNIA 2DYMA 2I2ZA 1VZSA 3B9LA 3JRYA 4M70B 5D7GA 3ICXA 2OZBB 4ZBRA 4F5VA 5ID9A 3GA9L 4ZUXV 2JUHA 1BKEA 3NVMA 5IIHA 3H37A 2CKXA 3TDLA 2VUEA 2BXQA 4OR0A 4F5SA 3SQJA 1JNBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5IJ5 A;  2BXA A;  1E7G A;  4IW2 A;  4JK4 A;  2BXN A;  3LU6 A;  1E7F A;  2BXP A;  3A73 A;  2XW0 A;  4L9K A;  2BXL A;  3B9M A;  4HGM B;  3UIV A;  2XVU A;  2BXH A;  2BXB A;  3JQZ A;  4IW1 A;  2XVV A;  2XSI A;  3LU7 A;  1HK4 A;  5IFO A;  1HK3 A;  4E99 A;  1BM0 A;  2XVQ A;  4Z69 A;  1HK1 A;  1O9X A;  1GNJ A;  4LUF A;  4LB9 A;  2BXK A;  4J2V A;  2YDF A;  4BKE A;  5HOZ A;  2BXO A;  3V09 A;  1AO6 A;  4N0F D;  1N5U A;  1E78 A;  4L8U A;  1E7C A;  5FUO A;  4ZBQ A;  2BX8 A;  1J7E A;  1E7A A;  1KW2 A;  2XW1 A;  4S1Y A;  4LA0 A;  2BXM A;  5IJF A;  1E7B A;  1E7E A;  2I30 A;  4N0U D;  2BXI A;  4PO0 A;  4F5T A;  3V08 A;  2BXE A;  4LB2 A;  5DQF A;  1E7H A;  5ID7 A;  4F5U A;  4K71 A;  3V03 A;  5IIX A;  1HK2 A;  2BXG A;  1E7I A;  4L9Q A;  2BXC A;  3CX9 A;  1J78 A;  1TF0 A;  4G03 A;  4LUH A;  5IIU A;  4HGK A;  4G04 A;  2XVW A;  2BXD A;  1UOR A;  2VDB A;  4EMX A;  4K2C A;  3LU8 A;  2VUF A;  1LOT A;  2BXF A;  5GHK A;  5IJE A;  1H9Z A;  1BJ5 A;  1HK5 A;  4OT2 A;  1MA9 A;  5DBY A;  1KXP D;  1HA2 A;  1GNI A;  2I2Z A;  3B9L A;  3JRY A;  4ZBR A;  4F5V A;  5ID9 A;  1BKE A;  5IIH A;  3TDL A;  2VUE A;  2BXQ A;  4OR0 A;  4F5S A;  3SQJ A; 
#chains in the Genus database with same CATH topology
 5IJ5 A;  2BXA A;  4W4U B;  5GIP A;  1E7G A;  4IW2 A;  2DBU A;  1H5W A;  2E0Y A;  5B5T A;  2QM6 A;  4JK4 A;  1SB0 A;  4G01 A;  2BXN A;  3LU6 A;  3W1S A;  1E7F A;  2BXP A;  3A73 A;  4N3Z A;  3MHH B;  2XW0 A;  2E0X A;  4L9K A;  4BY9 C;  4OTT A;  3G9K D;  2BXL A;  3B9M A;  4HGM B;  3UIV A;  3NVK A;  2XMO A;  2XVU A;  3ECP A;  2BXH A;  2BXB A;  3GQX A;  3JQZ A;  4IW1 A;  2KBZ A;  2XVV A;  4D7X A;  2XSI A;  2AGH B;  1HK4 A;  3LU7 A;  1HK3 A;  5IFO A;  4E99 A;  3A75 A;  3NMU A;  3WHR A;  1BM0 A;  1NT2 B;  4NAW B;  1MM8 A;  2XVQ A;  3KJL A;  3SIV B;  4Z69 A;  1HK1 A;  2LXT A;  4MBE C;  1O9X A;  3FWB C;  2EFD A;  1MUS A;  4TQ1 A;  1GNJ A;  2DBW A;  4GDK B;  2DG5 A;  4LB9 A;  4LUF A;  2BXK A;  4J2V A;  2YDF A;  4BKE A;  5HOZ A;  2BXO A;  3V09 A;  3WHQ A;  2KWF A;  1AO6 A;  4N0F D;  1N5U A;  1E78 A;  2EFE A;  4OTU A;  2DYO A;  4ZCG A;  4L8U A;  3NVI A;  1E7C A;  5FUO A;  1IJG A;  4ZBQ A;  5GIO A;  2BX8 A;  3SIU B;  1J7E A;  1E7A A;  1KW2 A;  2XW1 A;  4ZC6 A;  4GG2 A;  4S1Y A;  4LA0 A;  2BXM A;  5IJF A;  1E7B A;  1E7E A;  3BPJ A;  2ROH A;  2I30 A;  4C31 B;  4I9O A;  2V36 A;  4DHX B;  4N0U D;  2BXI A;  4PO0 A;  4F5T A;  3V08 A;  2BXE A;  1MUH A;  4LB2 A;  5DQF A;  1E7H A;  5ID7 A;  4F5U A;  4K71 A;  3V03 A;  2LQI A;  5IIX A;  3KIK A;  1HK2 A;  4FIP B;  1KDX A;  2BXG A;  3MHS B;  1E7I A;  4Z9O A;  4WA6 B;  3FWC C;  4L9Q A;  2QMC A;  2BXC A;  1MIW A;  2Z8I A;  2EFH A;  1FOU A;  2DBX A;  3CX9 A;  1J78 A;  3M99 C;  1TF0 A;  2Z8J A;  2OT3 A;  4G03 A;  4LUH A;  5IIU A;  4HGK A;  4G04 A;  2XVW A;  4ZBK A;  2BXD A;  2QHB A;  1UOR A;  4FK5 B;  2NQO A;  2VDB A;  4EMX A;  1MIV A;  2Z8K A;  2NNW A;  3H3A A;  3LU8 A;  4FJC B;  4K2C A;  1TXU A;  5BPK A;  2LOQ A;  2VUF A;  4GDX A;  1VFI A;  1LOT A;  2BXF A;  4TQ0 A;  5GIN A;  5GHK A;  5IJE A;  2AJE A;  1H9Z A;  1MIY A;  3VQI A;  3PLA A;  1BJ5 A;  4GDL B;  1HK5 A;  4OT2 A;  4DM0 A;  1MA9 A;  5DBY A;  3WHS A;  2EFC A;  1KXP D;  1LNS A;  1HA2 A;  2LQH A;  3GQU A;  3FNM A;  1GNI A;  2DYM A;  2I2Z A;  1VZS A;  3B9L A;  3JRY A;  4M70 B;  5D7G A;  3ICX A;  2OZB B;  4ZBR A;  4F5V A;  5ID9 A;  3GA9 L;  4ZUX V;  2JUH A;  1BKE A;  3NVM A;  2LXS A;  5IIH A;  3H37 A;  2CKX A;  3TDL A;  2VUE A;  2BXQ A;  4OR0 A;  4F5S A;  2GUT A;  2K0N A;  3SQJ A;  1JNB A; 
#chains in the Genus database with same CATH homology
 5IJ5 A;  2BXA A;  4W4U B;  5GIP A;  1E7G A;  4IW2 A;  2DBU A;  1H5W A;  2E0Y A;  5B5T A;  2QM6 A;  4JK4 A;  4G01 A;  2BXN A;  3LU6 A;  3W1S A;  1E7F A;  2BXP A;  3A73 A;  4N3Z A;  3MHH B;  2XW0 A;  2E0X A;  4L9K A;  4BY9 C;  4OTT A;  3G9K D;  2BXL A;  3B9M A;  4HGM B;  3UIV A;  3NVK A;  2XMO A;  2XVU A;  2BXH A;  2BXB A;  3GQX A;  3JQZ A;  4IW1 A;  2KBZ A;  2XVV A;  2XSI A;  3LU7 A;  1HK4 A;  5IFO A;  1HK3 A;  4E99 A;  3A75 A;  3NMU A;  3WHR A;  1BM0 A;  1NT2 B;  4NAW B;  2XVQ A;  3KJL A;  3SIV B;  4Z69 A;  1HK1 A;  4MBE C;  1O9X A;  3FWB C;  2EFD A;  4TQ1 A;  1GNJ A;  2DBW A;  4GDK B;  2DG5 A;  4LB9 A;  4LUF A;  2BXK A;  4J2V A;  2YDF A;  4BKE A;  5HOZ A;  2BXO A;  3V09 A;  3WHQ A;  1AO6 A;  4N0F D;  1N5U A;  1E78 A;  2EFE A;  4OTU A;  2DYO A;  4ZCG A;  4L8U A;  3NVI A;  1E7C A;  5FUO A;  1IJG A;  4ZBQ A;  5GIO A;  2BX8 A;  3SIU B;  1J7E A;  1E7A A;  1KW2 A;  2XW1 A;  4ZC6 A;  4GG2 A;  4S1Y A;  4LA0 A;  2BXM A;  5IJF A;  1E7B A;  1E7E A;  2ROH A;  2I30 A;  4C31 B;  2V36 A;  4DHX B;  4N0U D;  2BXI A;  4PO0 A;  4F5T A;  3V08 A;  2BXE A;  4LB2 A;  5DQF A;  1E7H A;  5ID7 A;  4F5U A;  4K71 A;  3V03 A;  5IIX A;  3KIK A;  1HK2 A;  4FIP B;  2BXG A;  3MHS B;  1E7I A;  4Z9O A;  4WA6 B;  3FWC C;  4L9Q A;  2QMC A;  2BXC A;  1MIW A;  2Z8I A;  2EFH A;  1FOU A;  2DBX A;  3CX9 A;  1J78 A;  3M99 C;  1TF0 A;  2Z8J A;  2OT3 A;  4G03 A;  4LUH A;  5IIU A;  4HGK A;  4G04 A;  2XVW A;  4ZBK A;  2BXD A;  2QHB A;  1UOR A;  4FK5 B;  2NQO A;  2VDB A;  4EMX A;  1MIV A;  2Z8K A;  2NNW A;  3H3A A;  3LU8 A;  4FJC B;  4K2C A;  1TXU A;  5BPK A;  2LOQ A;  2VUF A;  4GDX A;  1VFI A;  1LOT A;  2BXF A;  4TQ0 A;  5GIN A;  5GHK A;  5IJE A;  2AJE A;  1H9Z A;  1MIY A;  3VQI A;  3PLA A;  1BJ5 A;  4GDL B;  1HK5 A;  4OT2 A;  1MA9 A;  5DBY A;  3WHS A;  2EFC A;  1KXP D;  1LNS A;  1HA2 A;  3GQU A;  3FNM A;  1GNI A;  2DYM A;  2I2Z A;  1VZS A;  3B9L A;  3JRY A;  4M70 B;  5D7G A;  3ICX A;  2OZB B;  4ZBR A;  4F5V A;  5ID9 A;  3GA9 L;  4ZUX V;  2JUH A;  1BKE A;  3NVM A;  5IIH A;  3H37 A;  2CKX A;  3TDL A;  2VUE A;  2BXQ A;  4OR0 A;  4F5S A;  3SQJ A;  1JNB A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...