1HK1A

Human serum albumin complexed with thyroxine (3,3',5,5'-tetraiodo-l-thyronine)
Total Genus 210
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
210
sequence length
565
structure length
553
Chain Sequence
SEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTDCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis of Albumin-Thyroxine Interactions and Familial Dysalbuminemic Hyperthyroxinemia
pubmed doi rcsb
molecule tags Plasma protein
source organism Homo sapiens
molecule keywords SERUM ALBUMIN
total genus 210
structure length 553
sequence length 565
ec nomenclature
pdb deposition date 2003-03-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk1A03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk1A02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk1A04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk1A01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk1A06
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk1A05
3TDLA 4JK4A 4F5UA 2I2ZA 4S1YA 4Z69A 4LUHA 1GNJA 3JRYA 1E7AA 5IIUA 3LU8A 4ZBRA 1LOTA 1BKEA 2BXNA 4PO0A 1UORA 1BM0A 3V08A 3V03A 1N5UA 1E78A 2BXGA 4IW1A 2XW1A 2I30A 5IJ5A 4N0UD 5IIHA 2BXKA 1O9XA 5IJEA 5GHKA 3UIVA 4BKEA 1E7HA 5ID9A 2BXEA 1HK5A 1HK3A 5HOZA 2XVVA 1AO6A 4L8UA 1KXPD 2VUEA 1GNIA 2BXLA 1HA2A 4E99A 2BXDA 2VDBA 4LB2A 4LUFA 4ZBQA 1J7EA 4F5VA 5FUOA 1E7GA 2XSIA 4OT2A 4LA0A 1E7FA 1KW2A 5DQFA 3LU6A 4IW2A 4L9KA 1HK2A 3A73A 2BXFA 1E7EA 2XVQA 2BXOA 3LU7A 2BXQA 2XVUA 5ID7A 2BXHA 4LB9A 2BX8A 1E7CA 5IIXA 2BXCA 3SQJA 2XW0A 3CX9A 4F5TA 5IJFA 4EMXA 1HK4A 2VUFA 1MA9A 2BXPA 5DBYA 1E7IA 5IFOA 1BJ5A 3V09A 4F5SA 2BXBA 3B9LA 1E7BA 4OR0A 2BXMA 3JQZA 2XVWA 4HGKA 4J2VA 4K2CA 4G04A 1H9ZA 4G03A 4K71A 2YDFA 1TF0A 4L9QA 1J78A 3B9MA 2BXIA 2BXAA 4N0FD 4HGMB 1HK1A
chains in the Genus database with same CATH superfamily
3TDLA 2EFEA 4OTUA 1MUHA 2ROHA 4G01A 4JK4A 4F5UA 2I2ZA 4HGMB 2DBXA 4S1YA 4TQ0A 4Z69A 4ZUXV 5GIPA 3NVKA 3KIKA 4ZCGA 2DYOA 2GUTA 4LUHA 2LXTA 1GNJA 3JRYA 1E7AA 5IIUA 3LU8A 2LQIA 4ZBRA 1SB0A 1LOTA 2QHBA 1MM8A 1BKEA 5BPKA 2BXNA 2Z8KA 4PO0A 1UORA 1BM0A 3GQXA 3V08A 3V03A 1N5UA 1E78A 2BXGA 4IW1A 2AJEA 1IJGA 4I9OA 3ICXA 2XW1A 3NVIA 3A75A 4N3ZA 2I30A 5IJ5A 4N0UD 5B5TA 5IIHA 3H37A 2BXKA 1O9XA 1VFIA 5IJEA 2KWFA 5GHKA 3UIVA 1MIVA 4BKEA 1E7HA 4NAWB 5ID9A 2BXEA 1HK5A 2DYMA 1HK3A 5HOZA 1LNSA 2XVVA 4DM0A 3WHSA 4L8UA 1KXPD 2NQOA 1AO6A 3KJLA 1JNBA 2VUEA 3FWBC 2DBWA 4FJCB 1KDXA 1MIWA 1GNIA 2BXLA 3WHRA 4BY9C 3GQUA 1HA2A 4GDLB 3M99C 4E99A 2BXDA 2VDBA 3ECPA 4LB2A 4LUFA 4ZBQA 1J7EA 2E0XA 4F5VA 5FUOA 3W1SA 1E7GA 4D7XA 2XSIA 4OT2A 4LA0A 1E7FA 2OZBB 1KW2A 5DQFA 3LU6A 4IW2A 4L9KA 2K0NA 1HK2A 2EFDA 2XMOA 3A73A 2BXFA 1E7EA 2XVQA 1TXUA 5GINA 2BXOA 3LU7A 2AGHB 4ZBKA 2BXQA 3SIUB 4Z9OA 2XVUA 5ID7A 2LOQA 2BXHA 5D7GA 4LB9A 2BX8A 4C31B 2EFHA 1E7CA 1NT2B 2DG5A 2NNWA 5IIXA 2BXCA 3SQJA 2Z8IA 2QMCA 2XW0A 3CX9A 4F5TA 2OT3A 3WHQA 5IJFA 4EMXA 5GIOA 2DBUA 2KBZA 4W4UB 1FOUA 1H5WA 1HK4A 3H3AA 1VZSA 2VUFA 3SIVB 3NVMA 4GDKB 1MA9A 2BXPA 4ZC6A 2EFCA 5DBYA 3G9KD 2JUHA 1E7IA 4FK5B 3VQIA 4FIPB 2Z8JA 1BJ5A 4MBEC 5IFOA 3V09A 4F5SA 2BXBA 3BPJA 2E0YA 3B9LA 3FNMA 3PLAA 2CKXA 1E7BA 4OR0A 1MUSA 2BXMA 3JQZA 2XVWA 4GDXA 4HGKA 4WA6B 4J2VA 3FWCC 4K2CA 2LXSA 4G04A 1H9ZA 4G03A 4M70B 4K71A 2YDFA 4DHXB 3MHHB 1TF0A 1MIYA 3GA9L 4L9QA 3NMUA 2LQHA 1J78A 3B9MA 4OTTA 2BXIA 4TQ1A 2BXAA 2V36A 4GG2A 4N0FD 3MHSB 2QM6A 1HK1A
chains in the Genus database with same CATH topology
3TDLA 2EFEA 4OTUA 2ROHA 4G01A 4JK4A 4F5UA 2I2ZA 4HGMB 2DBXA 4S1YA 4TQ0A 4Z69A 4ZUXV 5GIPA 3NVKA 3KIKA 4ZCGA 2DYOA 4LUHA 1GNJA 3JRYA 1E7AA 5IIUA 3LU8A 4ZBRA 1LOTA 2QHBA 1BKEA 5BPKA 2BXNA 2Z8KA 4PO0A 1UORA 1BM0A 3GQXA 3V08A 3V03A 1N5UA 1E78A 2BXGA 4IW1A 2AJEA 1IJGA 3ICXA 2XW1A 3NVIA 3A75A 4N3ZA 2I30A 5IJ5A 4N0UD 5B5TA 5IIHA 3H37A 2BXKA 1O9XA 1VFIA 5IJEA 5GHKA 3UIVA 1MIVA 4BKEA 1E7HA 4NAWB 5ID9A 2BXEA 1HK5A 2DYMA 1HK3A 5HOZA 1LNSA 2XVVA 3WHSA 4L8UA 1KXPD 2NQOA 1AO6A 3KJLA 1JNBA 2VUEA 3FWBC 2DBWA 4FJCB 1MIWA 1GNIA 2BXLA 3WHRA 4BY9C 3GQUA 1HA2A 4GDLB 3M99C 4E99A 2BXDA 2VDBA 4LB2A 4LUFA 4ZBQA 1J7EA 2E0XA 4F5VA 5FUOA 3W1SA 1E7GA 2XSIA 4OT2A 4LA0A 1E7FA 2OZBB 1KW2A 5DQFA 3LU6A 4IW2A 4L9KA 1HK2A 2EFDA 2XMOA 3A73A 2BXFA 1E7EA 2XVQA 1TXUA 5GINA 2BXOA 3LU7A 4ZBKA 2BXQA 3SIUB 4Z9OA 2XVUA 5ID7A 2LOQA 2BXHA 5D7GA 4LB9A 2BX8A 4C31B 2EFHA 1E7CA 1NT2B 2DG5A 2NNWA 5IIXA 2BXCA 3SQJA 2Z8IA 2QMCA 2XW0A 3CX9A 4F5TA 2OT3A 3WHQA 5IJFA 4EMXA 5GIOA 2DBUA 2KBZA 4W4UB 1FOUA 1H5WA 1HK4A 3H3AA 1VZSA 2VUFA 3SIVB 3NVMA 4GDKB 1MA9A 2BXPA 4ZC6A 2EFCA 5DBYA 3G9KD 2JUHA 1E7IA 4FK5B 3VQIA 4FIPB 2Z8JA 1BJ5A 4MBEC 5IFOA 3V09A 4F5SA 2BXBA 2E0YA 3B9LA 3FNMA 3PLAA 2CKXA 1E7BA 4OR0A 2BXMA 3JQZA 2XVWA 4GDXA 4HGKA 4WA6B 4J2VA 3FWCC 4K2CA 4G04A 1H9ZA 4G03A 4M70B 4K71A 2YDFA 4DHXB 3MHHB 1TF0A 1MIYA 3GA9L 4L9QA 3NMUA 1J78A 3B9MA 4OTTA 2BXIA 4TQ1A 2BXAA 2V36A 4GG2A 4N0FD 3MHSB 2QM6A 1HK1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3TDL A;  4JK4 A;  4F5U A;  2I2Z A;  4S1Y A;  4Z69 A;  4LUH A;  1GNJ A;  3JRY A;  1E7A A;  5IIU A;  3LU8 A;  4ZBR A;  1LOT A;  1BKE A;  2BXN A;  4PO0 A;  1UOR A;  1BM0 A;  3V08 A;  3V03 A;  1N5U A;  1E78 A;  2BXG A;  4IW1 A;  2XW1 A;  2I30 A;  5IJ5 A;  4N0U D;  5IIH A;  2BXK A;  1O9X A;  5IJE A;  5GHK A;  3UIV A;  4BKE A;  1E7H A;  5ID9 A;  2BXE A;  1HK5 A;  1HK3 A;  5HOZ A;  2XVV A;  1AO6 A;  4L8U A;  1KXP D;  2VUE A;  1GNI A;  2BXL A;  1HA2 A;  4E99 A;  2BXD A;  2VDB A;  4LB2 A;  4LUF A;  4ZBQ A;  1J7E A;  4F5V A;  5FUO A;  1E7G A;  2XSI A;  4OT2 A;  4LA0 A;  1E7F A;  1KW2 A;  5DQF A;  3LU6 A;  4IW2 A;  4L9K A;  1HK2 A;  3A73 A;  2BXF A;  1E7E A;  2XVQ A;  2BXO A;  3LU7 A;  2BXQ A;  2XVU A;  5ID7 A;  2BXH A;  4LB9 A;  2BX8 A;  1E7C A;  5IIX A;  2BXC A;  3SQJ A;  2XW0 A;  3CX9 A;  4F5T A;  5IJF A;  4EMX A;  1HK4 A;  2VUF A;  1MA9 A;  2BXP A;  5DBY A;  1E7I A;  5IFO A;  1BJ5 A;  3V09 A;  4F5S A;  2BXB A;  3B9L A;  1E7B A;  4OR0 A;  2BXM A;  3JQZ A;  2XVW A;  4HGK A;  4J2V A;  4K2C A;  4G04 A;  1H9Z A;  4G03 A;  4K71 A;  2YDF A;  1TF0 A;  4L9Q A;  1J78 A;  3B9M A;  2BXI A;  2BXA A;  4N0F D;  4HGM B;  1HK1 A; 
#chains in the Genus database with same CATH topology
 3TDL A;  2EFE A;  4OTU A;  1MUH A;  2ROH A;  4G01 A;  4JK4 A;  4F5U A;  2I2Z A;  4HGM B;  2DBX A;  4S1Y A;  4TQ0 A;  4Z69 A;  4ZUX V;  5GIP A;  3NVK A;  3KIK A;  4ZCG A;  2DYO A;  2GUT A;  4LUH A;  2LXT A;  1GNJ A;  3JRY A;  1E7A A;  5IIU A;  3LU8 A;  2LQI A;  4ZBR A;  1SB0 A;  1LOT A;  2QHB A;  1MM8 A;  1BKE A;  5BPK A;  2BXN A;  2Z8K A;  4PO0 A;  1UOR A;  1BM0 A;  3GQX A;  3V08 A;  3V03 A;  1N5U A;  1E78 A;  2BXG A;  4IW1 A;  2AJE A;  1IJG A;  4I9O A;  3ICX A;  2XW1 A;  3NVI A;  3A75 A;  4N3Z A;  2I30 A;  5IJ5 A;  4N0U D;  5B5T A;  5IIH A;  3H37 A;  2BXK A;  1O9X A;  1VFI A;  5IJE A;  2KWF A;  5GHK A;  3UIV A;  1MIV A;  4BKE A;  1E7H A;  4NAW B;  5ID9 A;  2BXE A;  1HK5 A;  2DYM A;  1HK3 A;  5HOZ A;  1LNS A;  2XVV A;  4DM0 A;  3WHS A;  4L8U A;  1KXP D;  2NQO A;  1AO6 A;  3KJL A;  1JNB A;  2VUE A;  3FWB C;  2DBW A;  4FJC B;  1KDX A;  1MIW A;  1GNI A;  2BXL A;  3WHR A;  4BY9 C;  3GQU A;  1HA2 A;  4GDL B;  3M99 C;  4E99 A;  2BXD A;  2VDB A;  3ECP A;  4LB2 A;  4LUF A;  4ZBQ A;  1J7E A;  2E0X A;  4F5V A;  5FUO A;  3W1S A;  1E7G A;  4D7X A;  2XSI A;  4OT2 A;  4LA0 A;  1E7F A;  2OZB B;  1KW2 A;  5DQF A;  3LU6 A;  4IW2 A;  4L9K A;  2K0N A;  1HK2 A;  2EFD A;  2XMO A;  3A73 A;  2BXF A;  1E7E A;  2XVQ A;  1TXU A;  5GIN A;  2BXO A;  3LU7 A;  2AGH B;  4ZBK A;  2BXQ A;  3SIU B;  4Z9O A;  2XVU A;  5ID7 A;  2LOQ A;  2BXH A;  5D7G A;  4LB9 A;  2BX8 A;  4C31 B;  2EFH A;  1E7C A;  1NT2 B;  2DG5 A;  2NNW A;  5IIX A;  2BXC A;  3SQJ A;  2Z8I A;  2QMC A;  2XW0 A;  3CX9 A;  4F5T A;  2OT3 A;  3WHQ A;  5IJF A;  4EMX A;  5GIO A;  2DBU A;  2KBZ A;  4W4U B;  1FOU A;  1H5W A;  1HK4 A;  3H3A A;  1VZS A;  2VUF A;  3SIV B;  3NVM A;  4GDK B;  1MA9 A;  2BXP A;  4ZC6 A;  2EFC A;  5DBY A;  3G9K D;  2JUH A;  1E7I A;  4FK5 B;  3VQI A;  4FIP B;  2Z8J A;  1BJ5 A;  4MBE C;  5IFO A;  3V09 A;  4F5S A;  2BXB A;  3BPJ A;  2E0Y A;  3B9L A;  3FNM A;  3PLA A;  2CKX A;  1E7B A;  4OR0 A;  1MUS A;  2BXM A;  3JQZ A;  2XVW A;  4GDX A;  4HGK A;  4WA6 B;  4J2V A;  3FWC C;  4K2C A;  2LXS A;  4G04 A;  1H9Z A;  4G03 A;  4M70 B;  4K71 A;  2YDF A;  4DHX B;  3MHH B;  1TF0 A;  1MIY A;  3GA9 L;  4L9Q A;  3NMU A;  2LQH A;  1J78 A;  3B9M A;  4OTT A;  2BXI A;  4TQ1 A;  2BXA A;  2V36 A;  4GG2 A;  4N0F D;  3MHS B;  2QM6 A;  1HK1 A; 
#chains in the Genus database with same CATH homology
 3TDL A;  2EFE A;  4OTU A;  2ROH A;  4G01 A;  4JK4 A;  4F5U A;  2I2Z A;  4HGM B;  2DBX A;  4S1Y A;  4TQ0 A;  4Z69 A;  4ZUX V;  5GIP A;  3NVK A;  3KIK A;  4ZCG A;  2DYO A;  4LUH A;  1GNJ A;  3JRY A;  1E7A A;  5IIU A;  3LU8 A;  4ZBR A;  1LOT A;  2QHB A;  1BKE A;  5BPK A;  2BXN A;  2Z8K A;  4PO0 A;  1UOR A;  1BM0 A;  3GQX A;  3V08 A;  3V03 A;  1N5U A;  1E78 A;  2BXG A;  4IW1 A;  2AJE A;  1IJG A;  3ICX A;  2XW1 A;  3NVI A;  3A75 A;  4N3Z A;  2I30 A;  5IJ5 A;  4N0U D;  5B5T A;  5IIH A;  3H37 A;  2BXK A;  1O9X A;  1VFI A;  5IJE A;  5GHK A;  3UIV A;  1MIV A;  4BKE A;  1E7H A;  4NAW B;  5ID9 A;  2BXE A;  1HK5 A;  2DYM A;  1HK3 A;  5HOZ A;  1LNS A;  2XVV A;  3WHS A;  4L8U A;  1KXP D;  2NQO A;  1AO6 A;  3KJL A;  1JNB A;  2VUE A;  3FWB C;  2DBW A;  4FJC B;  1MIW A;  1GNI A;  2BXL A;  3WHR A;  4BY9 C;  3GQU A;  1HA2 A;  4GDL B;  3M99 C;  4E99 A;  2BXD A;  2VDB A;  4LB2 A;  4LUF A;  4ZBQ A;  1J7E A;  2E0X A;  4F5V A;  5FUO A;  3W1S A;  1E7G A;  2XSI A;  4OT2 A;  4LA0 A;  1E7F A;  2OZB B;  1KW2 A;  5DQF A;  3LU6 A;  4IW2 A;  4L9K A;  1HK2 A;  2EFD A;  2XMO A;  3A73 A;  2BXF A;  1E7E A;  2XVQ A;  1TXU A;  5GIN A;  2BXO A;  3LU7 A;  4ZBK A;  2BXQ A;  3SIU B;  4Z9O A;  2XVU A;  5ID7 A;  2LOQ A;  2BXH A;  5D7G A;  4LB9 A;  2BX8 A;  4C31 B;  2EFH A;  1E7C A;  1NT2 B;  2DG5 A;  2NNW A;  5IIX A;  2BXC A;  3SQJ A;  2Z8I A;  2QMC A;  2XW0 A;  3CX9 A;  4F5T A;  2OT3 A;  3WHQ A;  5IJF A;  4EMX A;  5GIO A;  2DBU A;  2KBZ A;  4W4U B;  1FOU A;  1H5W A;  1HK4 A;  3H3A A;  1VZS A;  2VUF A;  3SIV B;  3NVM A;  4GDK B;  1MA9 A;  2BXP A;  4ZC6 A;  2EFC A;  5DBY A;  3G9K D;  2JUH A;  1E7I A;  4FK5 B;  3VQI A;  4FIP B;  2Z8J A;  1BJ5 A;  4MBE C;  5IFO A;  3V09 A;  4F5S A;  2BXB A;  2E0Y A;  3B9L A;  3FNM A;  3PLA A;  2CKX A;  1E7B A;  4OR0 A;  2BXM A;  3JQZ A;  2XVW A;  4GDX A;  4HGK A;  4WA6 B;  4J2V A;  3FWC C;  4K2C A;  4G04 A;  1H9Z A;  4G03 A;  4M70 B;  4K71 A;  2YDF A;  4DHX B;  3MHH B;  1TF0 A;  1MIY A;  3GA9 L;  4L9Q A;  3NMU A;  1J78 A;  3B9M A;  4OTT A;  2BXI A;  4TQ1 A;  2BXA A;  2V36 A;  4GG2 A;  4N0F D;  3MHS B;  2QM6 A;  1HK1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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