1HK2A

Human serum albumin mutant r218h complexed with thyroxine (3,3',5,5'-tetraiodo-l-thyronine)
Total Genus 210
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
210
sequence length
572
structure length
560
Chain Sequence
SEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTDCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVAHLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis of Albumin-Thyroxine Interactions and Familial Dysalbuminemic Hyperthyroxinemia
pubmed doi rcsb
molecule tags Plasma protein
source organism Homo sapiens
molecule keywords SERUM ALBUMIN
total genus 210
structure length 560
sequence length 572
ec nomenclature
pdb deposition date 2003-03-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk2A03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk2A02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk2A04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk2A01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk2A06
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk2A05
1O9XA 4K71A 4LUHA 1BJ5A 4J2VA 2BXMA 1E7HA 2I30A 1HK1A 4G04A 2BXFA 1KXPD 4ZBRA 4HGMB 3A73A 4N0FD 2BXHA 3JQZA 1AO6A 1BKEA 2XSIA 1HA2A 1N5UA 4E99A 1LOTA 2YDFA 4BKEA 5FUOA 3V08A 3V09A 4LB9A 3SQJA 2BXCA 1E7GA 5IIXA 1E7FA 4HGKA 4F5VA 2VUFA 4IW1A 5DBYA 4LUFA 4G03A 2BXBA 3V03A 1E7AA 3CX9A 3LU6A 1J78A 3LU8A 4F5TA 1HK2A 1BM0A 2BXAA 4OT2A 1HK3A 5IIUA 4Z69A 1GNIA 1E7CA 2VUEA 2BXKA 3JRYA 2BX8A 1HK5A 4K2CA 2BXGA 1H9ZA 1E7IA 2XVVA 1UORA 4L8UA 4PO0A 1TF0A 2I2ZA 4JK4A 2XW1A 3B9LA 5IFOA 2BXLA 1J7EA 1GNJA 5IJEA 1E7EA 4EMXA 5IJFA 1HK4A 4L9QA 2BXQA 2XVQA 4N0UD 4L9KA 2VDBA 4F5SA 2BXNA 4ZBQA 5ID7A 1E78A 1MA9A 5IIHA 2BXPA 1KW2A 3TDLA 3UIVA 4LA0A 2BXOA 5DQFA 2XVWA 5HOZA 2BXDA 4IW2A 3B9MA 4S1YA 4OR0A 5GHKA 4F5UA 5IJ5A 2XVUA 2XW0A 3LU7A 1E7BA 2BXEA 5ID9A 2BXIA 4LB2A
chains in the Genus database with same CATH superfamily
2LQIA 3WHSA 1O9XA 4K71A 4LUHA 1BJ5A 2LQHA 2DBWA 4J2VA 2BXMA 1E7HA 2I30A 4I9OA 3PLAA 2LXSA 3WHRA 4FK5B 2ROHA 1HK1A 4OTUA 3GQXA 2LOQA 4ZC6A 2AGHB 4GDLB 4G04A 4Z9OA 2BXFA 1KDXA 4N3ZA 1KXPD 2CKXA 2DBXA 4ZBRA 2NNWA 3NVKA 5GINA 4HGMB 3GA9L 3A73A 4ZUXV 4N0FD 1MUHA 3SIVB 2BXHA 5D7GA 3JQZA 2E0YA 1AO6A 2Z8JA 3MHSB 1BKEA 2XSIA 3NMUA 2EFCA 1HA2A 1N5UA 4MBEC 4FJCB 1LOTA 4E99A 2YDFA 4BKEA 5FUOA 3V08A 4W4UB 4DM0A 3V09A 4LB9A 1IJGA 4ZBKA 3SQJA 2BXCA 2XMOA 2Z8IA 1MIWA 2KWFA 3WHQA 4BY9C 1E7GA 3BPJA 5IIXA 1E7FA 2JUHA 4TQ0A 4HGKA 4F5VA 2EFEA 2VUFA 2QMCA 4GDXA 4IW1A 2DYOA 3ECPA 5DBYA 4LUFA 4G03A 4TQ1A 2BXBA 3GQUA 1H5WA 4LB2A 4OTTA 3V03A 1FOUA 4GG2A 2EFHA 1E7AA 3CX9A 3LU6A 1J78A 3LU8A 2GUTA 4M70B 4F5TA 3VQIA 1HK2A 4NAWB 1BM0A 2BXAA 4OT2A 1HK3A 5IIUA 4Z69A 2DYMA 1GNIA 1NT2B 1E7CA 2VUEA 2BXKA 3G9KD 3JRYA 1MIYA 2BX8A 4DHXB 1HK5A 4K2CA 2BXGA 4ZCGA 3H3AA 2OZBB 3FNMA 3A75A 1H9ZA 1E7IA 4D7XA 2XVVA 5GIOA 3NVMA 1UORA 4L8UA 4PO0A 4C31B 3M99C 1TF0A 2I2ZA 4JK4A 2XW1A 2NQOA 3B9LA 5IFOA 2BXLA 2QHBA 1J7EA 2AJEA 1GNJA 2OT3A 5IJEA 1E7EA 4EMXA 3W1SA 5IJFA 1HK4A 4L9QA 2E0XA 2BXQA 2XVQA 4N0UD 4L9KA 3MHHB 2VDBA 4FIPB 2K0NA 4GDKB 1MIVA 4F5SA 2BXNA 5GIPA 4ZBQA 5ID7A 1VZSA 2DG5A 1MUSA 3KIKA 1E78A 1MA9A 5IIHA 4WA6B 2BXPA 1VFIA 1KW2A 3TDLA 3UIVA 4LA0A 2BXOA 5DQFA 2XVWA 3FWBC 4G01A 1TXUA 1MM8A 5HOZA 2BXDA 4IW2A 3B9MA 3ICXA 4S1YA 3SIUB 2V36A 3H37A 1LNSA 4OR0A 5GHKA 4F5UA 2LXTA 5IJ5A 2XVUA 3FWCC 2XW0A 3LU7A 2EFDA 1SB0A 1JNBA 1E7BA 2BXEA 3KJLA 2KBZA 2DBUA 5B5TA 5ID9A 2QM6A 3NVIA 2BXIA 5BPKA 2Z8KA
chains in the Genus database with same CATH topology
3WHSA 1O9XA 4K71A 4LUHA 1BJ5A 2DBWA 4J2VA 2BXMA 1E7HA 2I30A 3PLAA 3WHRA 4FK5B 2ROHA 1HK1A 4OTUA 3GQXA 2LOQA 4ZC6A 4GDLB 4G04A 4Z9OA 2BXFA 4N3ZA 1KXPD 2CKXA 2DBXA 4ZBRA 2NNWA 3NVKA 5GINA 4HGMB 3GA9L 3A73A 4ZUXV 4N0FD 3SIVB 2BXHA 5D7GA 3JQZA 2E0YA 1AO6A 2Z8JA 3MHSB 1BKEA 2XSIA 3NMUA 2EFCA 1HA2A 1N5UA 4MBEC 4FJCB 1LOTA 4E99A 2YDFA 4BKEA 5FUOA 3V08A 4W4UB 3V09A 4LB9A 1IJGA 4ZBKA 3SQJA 2BXCA 2XMOA 2Z8IA 1MIWA 3WHQA 4BY9C 1E7GA 5IIXA 1E7FA 2JUHA 4TQ0A 4HGKA 4F5VA 2EFEA 2VUFA 2QMCA 4GDXA 4IW1A 2DYOA 5DBYA 4LUFA 4G03A 4TQ1A 2BXBA 3GQUA 1H5WA 4LB2A 4OTTA 3V03A 1FOUA 4GG2A 2EFHA 1E7AA 3CX9A 3LU6A 1J78A 3LU8A 4M70B 4F5TA 3VQIA 1HK2A 4NAWB 1BM0A 2BXAA 4OT2A 1HK3A 5IIUA 4Z69A 2DYMA 1GNIA 1NT2B 1E7CA 2VUEA 2BXKA 3G9KD 3JRYA 1MIYA 2BX8A 4DHXB 1HK5A 4K2CA 2BXGA 4ZCGA 3H3AA 2OZBB 3FNMA 3A75A 1H9ZA 1E7IA 2XVVA 5GIOA 3NVMA 1UORA 4L8UA 4PO0A 4C31B 3M99C 1TF0A 2I2ZA 4JK4A 2XW1A 2NQOA 3B9LA 5IFOA 2BXLA 2QHBA 1J7EA 2AJEA 1GNJA 2OT3A 5IJEA 1E7EA 4EMXA 3W1SA 5IJFA 1HK4A 4L9QA 2E0XA 2BXQA 2XVQA 4N0UD 4L9KA 3MHHB 2VDBA 4FIPB 4GDKB 1MIVA 4F5SA 2BXNA 5GIPA 4ZBQA 5ID7A 1VZSA 2DG5A 3KIKA 1E78A 1MA9A 5IIHA 4WA6B 2BXPA 1VFIA 1KW2A 3TDLA 3UIVA 4LA0A 2BXOA 5DQFA 2XVWA 3FWBC 4G01A 1TXUA 5HOZA 2BXDA 4IW2A 3B9MA 3ICXA 4S1YA 3SIUB 2V36A 3H37A 1LNSA 4OR0A 5GHKA 4F5UA 5IJ5A 2XVUA 3FWCC 2XW0A 3LU7A 2EFDA 1JNBA 1E7BA 2BXEA 3KJLA 2KBZA 2DBUA 5B5TA 5ID9A 2QM6A 3NVIA 2BXIA 5BPKA 2Z8KA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1O9X A;  4K71 A;  4LUH A;  1BJ5 A;  4J2V A;  2BXM A;  1E7H A;  2I30 A;  1HK1 A;  4G04 A;  2BXF A;  1KXP D;  4ZBR A;  4HGM B;  3A73 A;  4N0F D;  2BXH A;  3JQZ A;  1AO6 A;  1BKE A;  2XSI A;  1HA2 A;  1N5U A;  4E99 A;  1LOT A;  2YDF A;  4BKE A;  5FUO A;  3V08 A;  3V09 A;  4LB9 A;  3SQJ A;  2BXC A;  1E7G A;  5IIX A;  1E7F A;  4HGK A;  4F5V A;  2VUF A;  4IW1 A;  5DBY A;  4LUF A;  4G03 A;  2BXB A;  3V03 A;  1E7A A;  3CX9 A;  3LU6 A;  1J78 A;  3LU8 A;  4F5T A;  1HK2 A;  1BM0 A;  2BXA A;  4OT2 A;  1HK3 A;  5IIU A;  4Z69 A;  1GNI A;  1E7C A;  2VUE A;  2BXK A;  3JRY A;  2BX8 A;  1HK5 A;  4K2C A;  2BXG A;  1H9Z A;  1E7I A;  2XVV A;  1UOR A;  4L8U A;  4PO0 A;  1TF0 A;  2I2Z A;  4JK4 A;  2XW1 A;  3B9L A;  5IFO A;  2BXL A;  1J7E A;  1GNJ A;  5IJE A;  1E7E A;  4EMX A;  5IJF A;  1HK4 A;  4L9Q A;  2BXQ A;  2XVQ A;  4N0U D;  4L9K A;  2VDB A;  4F5S A;  2BXN A;  4ZBQ A;  5ID7 A;  1E78 A;  1MA9 A;  5IIH A;  2BXP A;  1KW2 A;  3TDL A;  3UIV A;  4LA0 A;  2BXO A;  5DQF A;  2XVW A;  5HOZ A;  2BXD A;  4IW2 A;  3B9M A;  4S1Y A;  4OR0 A;  5GHK A;  4F5U A;  5IJ5 A;  2XVU A;  2XW0 A;  3LU7 A;  1E7B A;  2BXE A;  5ID9 A;  2BXI A;  4LB2 A; 
#chains in the Genus database with same CATH topology
 2LQI A;  3WHS A;  1O9X A;  4K71 A;  4LUH A;  1BJ5 A;  2LQH A;  2DBW A;  4J2V A;  2BXM A;  1E7H A;  2I30 A;  4I9O A;  3PLA A;  2LXS A;  3WHR A;  4FK5 B;  2ROH A;  1HK1 A;  4OTU A;  3GQX A;  2LOQ A;  4ZC6 A;  2AGH B;  4GDL B;  4G04 A;  4Z9O A;  2BXF A;  1KDX A;  4N3Z A;  1KXP D;  2CKX A;  2DBX A;  4ZBR A;  2NNW A;  3NVK A;  5GIN A;  4HGM B;  3GA9 L;  3A73 A;  4ZUX V;  4N0F D;  1MUH A;  3SIV B;  2BXH A;  5D7G A;  3JQZ A;  2E0Y A;  1AO6 A;  2Z8J A;  3MHS B;  1BKE A;  2XSI A;  3NMU A;  2EFC A;  1HA2 A;  1N5U A;  4MBE C;  4FJC B;  1LOT A;  4E99 A;  2YDF A;  4BKE A;  5FUO A;  3V08 A;  4W4U B;  4DM0 A;  3V09 A;  4LB9 A;  1IJG A;  4ZBK A;  3SQJ A;  2BXC A;  2XMO A;  2Z8I A;  1MIW A;  2KWF A;  3WHQ A;  4BY9 C;  1E7G A;  3BPJ A;  5IIX A;  1E7F A;  2JUH A;  4TQ0 A;  4HGK A;  4F5V A;  2EFE A;  2VUF A;  2QMC A;  4GDX A;  4IW1 A;  2DYO A;  3ECP A;  5DBY A;  4LUF A;  4G03 A;  4TQ1 A;  2BXB A;  3GQU A;  1H5W A;  4LB2 A;  4OTT A;  3V03 A;  1FOU A;  4GG2 A;  2EFH A;  1E7A A;  3CX9 A;  3LU6 A;  1J78 A;  3LU8 A;  2GUT A;  4M70 B;  4F5T A;  3VQI A;  1HK2 A;  4NAW B;  1BM0 A;  2BXA A;  4OT2 A;  1HK3 A;  5IIU A;  4Z69 A;  2DYM A;  1GNI A;  1NT2 B;  1E7C A;  2VUE A;  2BXK A;  3G9K D;  3JRY A;  1MIY A;  2BX8 A;  4DHX B;  1HK5 A;  4K2C A;  2BXG A;  4ZCG A;  3H3A A;  2OZB B;  3FNM A;  3A75 A;  1H9Z A;  1E7I A;  4D7X A;  2XVV A;  5GIO A;  3NVM A;  1UOR A;  4L8U A;  4PO0 A;  4C31 B;  3M99 C;  1TF0 A;  2I2Z A;  4JK4 A;  2XW1 A;  2NQO A;  3B9L A;  5IFO A;  2BXL A;  2QHB A;  1J7E A;  2AJE A;  1GNJ A;  2OT3 A;  5IJE A;  1E7E A;  4EMX A;  3W1S A;  5IJF A;  1HK4 A;  4L9Q A;  2E0X A;  2BXQ A;  2XVQ A;  4N0U D;  4L9K A;  3MHH B;  2VDB A;  4FIP B;  2K0N A;  4GDK B;  1MIV A;  4F5S A;  2BXN A;  5GIP A;  4ZBQ A;  5ID7 A;  1VZS A;  2DG5 A;  1MUS A;  3KIK A;  1E78 A;  1MA9 A;  5IIH A;  4WA6 B;  2BXP A;  1VFI A;  1KW2 A;  3TDL A;  3UIV A;  4LA0 A;  2BXO A;  5DQF A;  2XVW A;  3FWB C;  4G01 A;  1TXU A;  1MM8 A;  5HOZ A;  2BXD A;  4IW2 A;  3B9M A;  3ICX A;  4S1Y A;  3SIU B;  2V36 A;  3H37 A;  1LNS A;  4OR0 A;  5GHK A;  4F5U A;  2LXT A;  5IJ5 A;  2XVU A;  3FWC C;  2XW0 A;  3LU7 A;  2EFD A;  1SB0 A;  1JNB A;  1E7B A;  2BXE A;  3KJL A;  2KBZ A;  2DBU A;  5B5T A;  5ID9 A;  2QM6 A;  3NVI A;  2BXI A;  5BPK A;  2Z8K A; 
#chains in the Genus database with same CATH homology
 3WHS A;  1O9X A;  4K71 A;  4LUH A;  1BJ5 A;  2DBW A;  4J2V A;  2BXM A;  1E7H A;  2I30 A;  3PLA A;  3WHR A;  4FK5 B;  2ROH A;  1HK1 A;  4OTU A;  3GQX A;  2LOQ A;  4ZC6 A;  4GDL B;  4G04 A;  4Z9O A;  2BXF A;  4N3Z A;  1KXP D;  2CKX A;  2DBX A;  4ZBR A;  2NNW A;  3NVK A;  5GIN A;  4HGM B;  3GA9 L;  3A73 A;  4ZUX V;  4N0F D;  3SIV B;  2BXH A;  5D7G A;  3JQZ A;  2E0Y A;  1AO6 A;  2Z8J A;  3MHS B;  1BKE A;  2XSI A;  3NMU A;  2EFC A;  1HA2 A;  1N5U A;  4MBE C;  4FJC B;  1LOT A;  4E99 A;  2YDF A;  4BKE A;  5FUO A;  3V08 A;  4W4U B;  3V09 A;  4LB9 A;  1IJG A;  4ZBK A;  3SQJ A;  2BXC A;  2XMO A;  2Z8I A;  1MIW A;  3WHQ A;  4BY9 C;  1E7G A;  5IIX A;  1E7F A;  2JUH A;  4TQ0 A;  4HGK A;  4F5V A;  2EFE A;  2VUF A;  2QMC A;  4GDX A;  4IW1 A;  2DYO A;  5DBY A;  4LUF A;  4G03 A;  4TQ1 A;  2BXB A;  3GQU A;  1H5W A;  4LB2 A;  4OTT A;  3V03 A;  1FOU A;  4GG2 A;  2EFH A;  1E7A A;  3CX9 A;  3LU6 A;  1J78 A;  3LU8 A;  4M70 B;  4F5T A;  3VQI A;  1HK2 A;  4NAW B;  1BM0 A;  2BXA A;  4OT2 A;  1HK3 A;  5IIU A;  4Z69 A;  2DYM A;  1GNI A;  1NT2 B;  1E7C A;  2VUE A;  2BXK A;  3G9K D;  3JRY A;  1MIY A;  2BX8 A;  4DHX B;  1HK5 A;  4K2C A;  2BXG A;  4ZCG A;  3H3A A;  2OZB B;  3FNM A;  3A75 A;  1H9Z A;  1E7I A;  2XVV A;  5GIO A;  3NVM A;  1UOR A;  4L8U A;  4PO0 A;  4C31 B;  3M99 C;  1TF0 A;  2I2Z A;  4JK4 A;  2XW1 A;  2NQO A;  3B9L A;  5IFO A;  2BXL A;  2QHB A;  1J7E A;  2AJE A;  1GNJ A;  2OT3 A;  5IJE A;  1E7E A;  4EMX A;  3W1S A;  5IJF A;  1HK4 A;  4L9Q A;  2E0X A;  2BXQ A;  2XVQ A;  4N0U D;  4L9K A;  3MHH B;  2VDB A;  4FIP B;  4GDK B;  1MIV A;  4F5S A;  2BXN A;  5GIP A;  4ZBQ A;  5ID7 A;  1VZS A;  2DG5 A;  3KIK A;  1E78 A;  1MA9 A;  5IIH A;  4WA6 B;  2BXP A;  1VFI A;  1KW2 A;  3TDL A;  3UIV A;  4LA0 A;  2BXO A;  5DQF A;  2XVW A;  3FWB C;  4G01 A;  1TXU A;  5HOZ A;  2BXD A;  4IW2 A;  3B9M A;  3ICX A;  4S1Y A;  3SIU B;  2V36 A;  3H37 A;  1LNS A;  4OR0 A;  5GHK A;  4F5U A;  5IJ5 A;  2XVU A;  3FWC C;  2XW0 A;  3LU7 A;  2EFD A;  1JNB A;  1E7B A;  2BXE A;  3KJL A;  2KBZ A;  2DBU A;  5B5T A;  5ID9 A;  2QM6 A;  3NVI A;  2BXI A;  5BPK A;  2Z8K A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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