1HK2A

Human serum albumin mutant r218h complexed with thyroxine (3,3',5,5'-tetraiodo-l-thyronine)
Total Genus 210
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
210
sequence length
572
structure length
560
Chain Sequence
SEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTDCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVAHLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis of Albumin-Thyroxine Interactions and Familial Dysalbuminemic Hyperthyroxinemia
pubmed doi rcsb
molecule tags Plasma protein
source organism Homo sapiens
molecule keywords SERUM ALBUMIN
total genus 210
structure length 560
sequence length 572
ec nomenclature
pdb deposition date 2003-03-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk2A03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk2A02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk2A04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk2A01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk2A06
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk2A05
1H9ZA 4K71A 2BXGA 2BXFA 4S1YA 2BXMA 4IW2A 4F5UA 2BXQA 3B9MA 2BXLA 1BKEA 3A73A 4ZBQA 4L8UA 4N0UD 1E7GA 4L9QA 4K2CA 2BXEA 5HOZA 2BXAA 3LU8A 2VUEA 1J78A 1E7AA 3TDLA 2BXDA 3SQJA 1HK5A 5IJEA 2VDBA 1HK1A 3B9LA 1GNIA 2BXIA 4E99A 1KXPD 4J2VA 2XVUA 5DQFA 4PO0A 4F5VA 4Z69A 5ID9A 1E7EA 1HK2A 4OR0A 2VUFA 2XVVA 1E78A 2BXCA 4F5SA 5FUOA 4LB2A 1BM0A 3CX9A 1AO6A 4EMXA 5IIXA 1N5UA 5GHKA 1E7FA 5IJ5A 2XSIA 2YDFA 4G04A 1E7IA 1MA9A 2BXHA 3LU7A 4ZBRA 1J7EA 2BXOA 3V08A 2XW0A 3V03A 3V09A 2XVQA 3LU6A 2BXNA 1UORA 1BJ5A 3JQZA 5IIUA 3UIVA 2I2ZA 1HA2A 1HK4A 1HK3A 1TF0A 5IIHA 5IJFA 2BXKA 5IFOA 4JK4A 2BXBA 2XVWA 1E7BA 1E7HA 4N0FD 4LA0A 4LB9A 5ID7A 4L9KA 1O9XA 2BX8A 2I30A 1GNJA 1KW2A 4OT2A 1LOTA 4HGKA 4F5TA 3JRYA 4BKEA 2BXPA 1E7CA 2XW1A 4HGMB 4LUHA 4IW1A 4LUFA 5DBYA 4G03A
chains in the Genus database with same CATH superfamily
2Z8JA 4FJCB 1H9ZA 4Z9OA 3G9KD 2EFCA 4K71A 2BXGA 2BXFA 4S1YA 2BXMA 4IW2A 4F5UA 4DM0A 2BXQA 5GIOA 2OT3A 3B9MA 4ZUXV 2BXLA 2OZBB 4FK5B 1BKEA 3A73A 2V36A 4ZBQA 3WHQA 2EFDA 4L8UA 2JUHA 1E7GA 4N0UD 3W1SA 3NVIA 2LQIA 4L9QA 4K2CA 4FIPB 2BXEA 2XMOA 5HOZA 2BXAA 3LU8A 4ZBKA 1IJGA 2VUEA 1J78A 2LXTA 1E7AA 3TDLA 2BXDA 1H5WA 4TQ0A 3SQJA 1HK5A 5IJEA 2DYOA 1SB0A 4W4UB 2VDBA 3FWBC 1HK1A 2KBZA 3B9LA 3FWCC 1GNIA 2BXIA 2DBXA 4E99A 1KXPD 4J2VA 3GQXA 2XVUA 4GDKB 3NVKA 4OTTA 3WHSA 5GINA 2DBUA 5DQFA 4PO0A 4F5VA 4Z69A 5ID9A 2Z8KA 1E7EA 4I9OA 1HK2A 3VQIA 2E0XA 4OR0A 2VUFA 2NQOA 2XVVA 1E78A 2BXCA 3H3AA 4F5SA 5FUOA 4LB2A 1KDXA 1BM0A 1MIYA 1JNBA 3CX9A 1AO6A 4EMXA 3NMUA 2QMCA 5IIXA 2QM6A 1MUHA 4C31B 2LQHA 4GDXA 1N5UA 3PLAA 5GHKA 4MBEC 1E7FA 3KIKA 5IJ5A 1VFIA 2XSIA 2YDFA 4G04A 4OTUA 1MIWA 1FOUA 1E7IA 1MA9A 2BXHA 5BPKA 3LU7A 2K0NA 2EFHA 3BPJA 4ZBRA 1J7EA 2BXOA 1MIVA 3V08A 2NNWA 2LOQA 2XW0A 5D7GA 2AGHB 1VZSA 2LXSA 3MHHB 4ZC6A 5B5TA 1LNSA 3V03A 1MUSA 4GG2A 3V09A 3H37A 3M99C 2XVQA 3LU6A 1NT2B 2BXNA 4NAWB 1UORA 4ZCGA 1BJ5A 3JQZA 5IIUA 3UIVA 2QHBA 2I2ZA 1HA2A 3KJLA 1HK4A 1HK3A 1TF0A 5IIHA 5IJFA 2BXKA 4G01A 5IFOA 4WA6B 4JK4A 2BXBA 1MM8A 5GIPA 3NVMA 3ICXA 4D7XA 2DG5A 1E7BA 2XVWA 1E7HA 2AJEA 4GDLB 4N3ZA 4N0FD 4BY9C 4LA0A 4LB9A 3MHSB 2Z8IA 5ID7A 3SIUB 4L9KA 1O9XA 2EFEA 2BX8A 4DHXB 2I30A 1GNJA 3WHRA 3SIVB 1KW2A 3FNMA 4OT2A 1LOTA 3A75A 2DBWA 4HGKA 2DYMA 4TQ1A 2GUTA 4F5TA 3JRYA 3GA9L 4BKEA 2KWFA 2ROHA 2BXPA 1E7CA 2XW1A 4HGMB 2E0YA 3GQUA 4LUHA 4M70B 3ECPA 1TXUA 4IW1A 2CKXA 4LUFA 5DBYA 4G03A
chains in the Genus database with same CATH topology
2Z8JA 4FJCB 1H9ZA 4Z9OA 3G9KD 2EFCA 4K71A 2BXGA 2BXFA 4S1YA 2BXMA 4IW2A 4F5UA 2BXQA 5GIOA 2OT3A 3B9MA 4ZUXV 2BXLA 2OZBB 4FK5B 1BKEA 3A73A 2V36A 4ZBQA 3WHQA 2EFDA 4L8UA 2JUHA 1E7GA 4N0UD 3W1SA 3NVIA 4L9QA 4K2CA 4FIPB 2BXEA 2XMOA 5HOZA 2BXAA 3LU8A 4ZBKA 1IJGA 2VUEA 1J78A 1E7AA 3TDLA 2BXDA 1H5WA 4TQ0A 3SQJA 1HK5A 5IJEA 2DYOA 4W4UB 2VDBA 3FWBC 1HK1A 2KBZA 3B9LA 3FWCC 1GNIA 2BXIA 2DBXA 4E99A 1KXPD 4J2VA 3GQXA 2XVUA 4GDKB 3NVKA 4OTTA 3WHSA 5GINA 2DBUA 5DQFA 4PO0A 4F5VA 4Z69A 5ID9A 2Z8KA 1E7EA 1HK2A 3VQIA 2E0XA 4OR0A 2VUFA 2NQOA 2XVVA 1E78A 2BXCA 3H3AA 4F5SA 5FUOA 4LB2A 1BM0A 1MIYA 1JNBA 3CX9A 1AO6A 4EMXA 3NMUA 2QMCA 5IIXA 2QM6A 4C31B 4GDXA 1N5UA 3PLAA 5GHKA 4MBEC 1E7FA 3KIKA 5IJ5A 1VFIA 2XSIA 2YDFA 4G04A 4OTUA 1MIWA 1FOUA 1E7IA 1MA9A 2BXHA 5BPKA 3LU7A 2EFHA 4ZBRA 1J7EA 2BXOA 1MIVA 3V08A 2NNWA 2LOQA 2XW0A 5D7GA 3MHHB 1VZSA 4ZC6A 5B5TA 1LNSA 3V03A 4GG2A 3V09A 3H37A 3M99C 2XVQA 3LU6A 1NT2B 2BXNA 4NAWB 1UORA 4ZCGA 1BJ5A 3JQZA 5IIUA 3UIVA 2QHBA 2I2ZA 1HA2A 3KJLA 1HK4A 1HK3A 1TF0A 5IIHA 5IJFA 2BXKA 4G01A 5IFOA 4WA6B 4JK4A 2BXBA 5GIPA 3NVMA 3ICXA 2DG5A 1E7BA 2XVWA 1E7HA 2AJEA 4GDLB 4N3ZA 4N0FD 4BY9C 4LA0A 4LB9A 3MHSB 2Z8IA 5ID7A 3SIUB 4L9KA 1O9XA 2EFEA 2BX8A 4DHXB 2I30A 1GNJA 3WHRA 3SIVB 1KW2A 3FNMA 4OT2A 1LOTA 3A75A 2DBWA 4HGKA 2DYMA 4TQ1A 4F5TA 3JRYA 3GA9L 4BKEA 2ROHA 2BXPA 1E7CA 2XW1A 4HGMB 2E0YA 3GQUA 4LUHA 4M70B 1TXUA 4IW1A 2CKXA 4LUFA 5DBYA 4G03A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1H9Z A;  4K71 A;  2BXG A;  2BXF A;  4S1Y A;  2BXM A;  4IW2 A;  4F5U A;  2BXQ A;  3B9M A;  2BXL A;  1BKE A;  3A73 A;  4ZBQ A;  4L8U A;  4N0U D;  1E7G A;  4L9Q A;  4K2C A;  2BXE A;  5HOZ A;  2BXA A;  3LU8 A;  2VUE A;  1J78 A;  1E7A A;  3TDL A;  2BXD A;  3SQJ A;  1HK5 A;  5IJE A;  2VDB A;  1HK1 A;  3B9L A;  1GNI A;  2BXI A;  4E99 A;  1KXP D;  4J2V A;  2XVU A;  5DQF A;  4PO0 A;  4F5V A;  4Z69 A;  5ID9 A;  1E7E A;  1HK2 A;  4OR0 A;  2VUF A;  2XVV A;  1E78 A;  2BXC A;  4F5S A;  5FUO A;  4LB2 A;  1BM0 A;  3CX9 A;  1AO6 A;  4EMX A;  5IIX A;  1N5U A;  5GHK A;  1E7F A;  5IJ5 A;  2XSI A;  2YDF A;  4G04 A;  1E7I A;  1MA9 A;  2BXH A;  3LU7 A;  4ZBR A;  1J7E A;  2BXO A;  3V08 A;  2XW0 A;  3V03 A;  3V09 A;  2XVQ A;  3LU6 A;  2BXN A;  1UOR A;  1BJ5 A;  3JQZ A;  5IIU A;  3UIV A;  2I2Z A;  1HA2 A;  1HK4 A;  1HK3 A;  1TF0 A;  5IIH A;  5IJF A;  2BXK A;  5IFO A;  4JK4 A;  2BXB A;  2XVW A;  1E7B A;  1E7H A;  4N0F D;  4LA0 A;  4LB9 A;  5ID7 A;  4L9K A;  1O9X A;  2BX8 A;  2I30 A;  1GNJ A;  1KW2 A;  4OT2 A;  1LOT A;  4HGK A;  4F5T A;  3JRY A;  4BKE A;  2BXP A;  1E7C A;  2XW1 A;  4HGM B;  4LUH A;  4IW1 A;  4LUF A;  5DBY A;  4G03 A; 
#chains in the Genus database with same CATH topology
 2Z8J A;  4FJC B;  1H9Z A;  4Z9O A;  3G9K D;  2EFC A;  4K71 A;  2BXG A;  2BXF A;  4S1Y A;  2BXM A;  4IW2 A;  4F5U A;  4DM0 A;  2BXQ A;  5GIO A;  2OT3 A;  3B9M A;  4ZUX V;  2BXL A;  2OZB B;  4FK5 B;  1BKE A;  3A73 A;  2V36 A;  4ZBQ A;  3WHQ A;  2EFD A;  4L8U A;  2JUH A;  1E7G A;  4N0U D;  3W1S A;  3NVI A;  2LQI A;  4L9Q A;  4K2C A;  4FIP B;  2BXE A;  2XMO A;  5HOZ A;  2BXA A;  3LU8 A;  4ZBK A;  1IJG A;  2VUE A;  1J78 A;  2LXT A;  1E7A A;  3TDL A;  2BXD A;  1H5W A;  4TQ0 A;  3SQJ A;  1HK5 A;  5IJE A;  2DYO A;  1SB0 A;  4W4U B;  2VDB A;  3FWB C;  1HK1 A;  2KBZ A;  3B9L A;  3FWC C;  1GNI A;  2BXI A;  2DBX A;  4E99 A;  1KXP D;  4J2V A;  3GQX A;  2XVU A;  4GDK B;  3NVK A;  4OTT A;  3WHS A;  5GIN A;  2DBU A;  5DQF A;  4PO0 A;  4F5V A;  4Z69 A;  5ID9 A;  2Z8K A;  1E7E A;  4I9O A;  1HK2 A;  3VQI A;  2E0X A;  4OR0 A;  2VUF A;  2NQO A;  2XVV A;  1E78 A;  2BXC A;  3H3A A;  4F5S A;  5FUO A;  4LB2 A;  1KDX A;  1BM0 A;  1MIY A;  1JNB A;  3CX9 A;  1AO6 A;  4EMX A;  3NMU A;  2QMC A;  5IIX A;  2QM6 A;  1MUH A;  4C31 B;  2LQH A;  4GDX A;  1N5U A;  3PLA A;  5GHK A;  4MBE C;  1E7F A;  3KIK A;  5IJ5 A;  1VFI A;  2XSI A;  2YDF A;  4G04 A;  4OTU A;  1MIW A;  1FOU A;  1E7I A;  1MA9 A;  2BXH A;  5BPK A;  3LU7 A;  2K0N A;  2EFH A;  3BPJ A;  4ZBR A;  1J7E A;  2BXO A;  1MIV A;  3V08 A;  2NNW A;  2LOQ A;  2XW0 A;  5D7G A;  2AGH B;  1VZS A;  2LXS A;  3MHH B;  4ZC6 A;  5B5T A;  1LNS A;  3V03 A;  1MUS A;  4GG2 A;  3V09 A;  3H37 A;  3M99 C;  2XVQ A;  3LU6 A;  1NT2 B;  2BXN A;  4NAW B;  1UOR A;  4ZCG A;  1BJ5 A;  3JQZ A;  5IIU A;  3UIV A;  2QHB A;  2I2Z A;  1HA2 A;  3KJL A;  1HK4 A;  1HK3 A;  1TF0 A;  5IIH A;  5IJF A;  2BXK A;  4G01 A;  5IFO A;  4WA6 B;  4JK4 A;  2BXB A;  1MM8 A;  5GIP A;  3NVM A;  3ICX A;  4D7X A;  2DG5 A;  1E7B A;  2XVW A;  1E7H A;  2AJE A;  4GDL B;  4N3Z A;  4N0F D;  4BY9 C;  4LA0 A;  4LB9 A;  3MHS B;  2Z8I A;  5ID7 A;  3SIU B;  4L9K A;  1O9X A;  2EFE A;  2BX8 A;  4DHX B;  2I30 A;  1GNJ A;  3WHR A;  3SIV B;  1KW2 A;  3FNM A;  4OT2 A;  1LOT A;  3A75 A;  2DBW A;  4HGK A;  2DYM A;  4TQ1 A;  2GUT A;  4F5T A;  3JRY A;  3GA9 L;  4BKE A;  2KWF A;  2ROH A;  2BXP A;  1E7C A;  2XW1 A;  4HGM B;  2E0Y A;  3GQU A;  4LUH A;  4M70 B;  3ECP A;  1TXU A;  4IW1 A;  2CKX A;  4LUF A;  5DBY A;  4G03 A; 
#chains in the Genus database with same CATH homology
 2Z8J A;  4FJC B;  1H9Z A;  4Z9O A;  3G9K D;  2EFC A;  4K71 A;  2BXG A;  2BXF A;  4S1Y A;  2BXM A;  4IW2 A;  4F5U A;  2BXQ A;  5GIO A;  2OT3 A;  3B9M A;  4ZUX V;  2BXL A;  2OZB B;  4FK5 B;  1BKE A;  3A73 A;  2V36 A;  4ZBQ A;  3WHQ A;  2EFD A;  4L8U A;  2JUH A;  1E7G A;  4N0U D;  3W1S A;  3NVI A;  4L9Q A;  4K2C A;  4FIP B;  2BXE A;  2XMO A;  5HOZ A;  2BXA A;  3LU8 A;  4ZBK A;  1IJG A;  2VUE A;  1J78 A;  1E7A A;  3TDL A;  2BXD A;  1H5W A;  4TQ0 A;  3SQJ A;  1HK5 A;  5IJE A;  2DYO A;  4W4U B;  2VDB A;  3FWB C;  1HK1 A;  2KBZ A;  3B9L A;  3FWC C;  1GNI A;  2BXI A;  2DBX A;  4E99 A;  1KXP D;  4J2V A;  3GQX A;  2XVU A;  4GDK B;  3NVK A;  4OTT A;  3WHS A;  5GIN A;  2DBU A;  5DQF A;  4PO0 A;  4F5V A;  4Z69 A;  5ID9 A;  2Z8K A;  1E7E A;  1HK2 A;  3VQI A;  2E0X A;  4OR0 A;  2VUF A;  2NQO A;  2XVV A;  1E78 A;  2BXC A;  3H3A A;  4F5S A;  5FUO A;  4LB2 A;  1BM0 A;  1MIY A;  1JNB A;  3CX9 A;  1AO6 A;  4EMX A;  3NMU A;  2QMC A;  5IIX A;  2QM6 A;  4C31 B;  4GDX A;  1N5U A;  3PLA A;  5GHK A;  4MBE C;  1E7F A;  3KIK A;  5IJ5 A;  1VFI A;  2XSI A;  2YDF A;  4G04 A;  4OTU A;  1MIW A;  1FOU A;  1E7I A;  1MA9 A;  2BXH A;  5BPK A;  3LU7 A;  2EFH A;  4ZBR A;  1J7E A;  2BXO A;  1MIV A;  3V08 A;  2NNW A;  2LOQ A;  2XW0 A;  5D7G A;  3MHH B;  1VZS A;  4ZC6 A;  5B5T A;  1LNS A;  3V03 A;  4GG2 A;  3V09 A;  3H37 A;  3M99 C;  2XVQ A;  3LU6 A;  1NT2 B;  2BXN A;  4NAW B;  1UOR A;  4ZCG A;  1BJ5 A;  3JQZ A;  5IIU A;  3UIV A;  2QHB A;  2I2Z A;  1HA2 A;  3KJL A;  1HK4 A;  1HK3 A;  1TF0 A;  5IIH A;  5IJF A;  2BXK A;  4G01 A;  5IFO A;  4WA6 B;  4JK4 A;  2BXB A;  5GIP A;  3NVM A;  3ICX A;  2DG5 A;  1E7B A;  2XVW A;  1E7H A;  2AJE A;  4GDL B;  4N3Z A;  4N0F D;  4BY9 C;  4LA0 A;  4LB9 A;  3MHS B;  2Z8I A;  5ID7 A;  3SIU B;  4L9K A;  1O9X A;  2EFE A;  2BX8 A;  4DHX B;  2I30 A;  1GNJ A;  3WHR A;  3SIV B;  1KW2 A;  3FNM A;  4OT2 A;  1LOT A;  3A75 A;  2DBW A;  4HGK A;  2DYM A;  4TQ1 A;  4F5T A;  3JRY A;  3GA9 L;  4BKE A;  2ROH A;  2BXP A;  1E7C A;  2XW1 A;  4HGM B;  2E0Y A;  3GQU A;  4LUH A;  4M70 B;  1TXU A;  4IW1 A;  2CKX A;  4LUF A;  5DBY A;  4G03 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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