1HK5A

Human serum albumin mutant r218h complexed with thyroxine (3,3',5,5'-tetraiodo-l-thyronine) and myristic acid (tetradecanoic acid)
Total Genus 218
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
218
sequence length
582
structure length
582
Chain Sequence
HKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVAHLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis of Albumin-Thyroxine Interactions and Familial Dysalbuminemic Hyperthyroxinemia
pubmed doi rcsb
molecule tags Plasma protein
source organism Homo sapiens
molecule keywords SERUM ALBUMIN
total genus 218
structure length 582
sequence length 582
ec nomenclature
pdb deposition date 2003-03-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk5A03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk5A02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk5A04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk5A01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk5A06
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1hk5A05
1J78A 1HA2A 1E7BA 3SQJA 1GNIA 2VUEA 4IW2A 4LB2A 1AO6A 3LU6A 3LU8A 4L8UA 3UIVA 1E7CA 4PO0A 2BXPA 3B9MA 4OT2A 4J2VA 2BXNA 3TDLA 5FUOA 4JK4A 1LOTA 2BXCA 4LB9A 5IJFA 2BXKA 5IJEA 2I30A 2BXGA 2I2ZA 5IFOA 2XW0A 4LUHA 4LUFA 3B9LA 4L9KA 5IIHA 2XVVA 1BM0A 1HK2A 1O9XA 3A73A 5IIUA 5DBYA 1HK1A 1TF0A 4K2CA 4L9QA 4LA0A 5GHKA 2XVQA 4F5SA 4ZBRA 1KXPD 2BXLA 3V03A 4OR0A 4IW1A 4BKEA 2YDFA 4HGMB 4G04A 2BX8A 2XSIA 5ID9A 1E7GA 1E7IA 5HOZA 2BXIA 3V09A 4N0UD 1E78A 2BXDA 4G03A 1E7EA 4K71A 2BXFA 3LU7A 3V08A 1MA9A 1H9ZA 1HK5A 1E7FA 5DQFA 2BXQA 4E99A 2BXHA 1N5UA 2XW1A 5ID7A 3CX9A 4EMXA 2BXBA 1J7EA 1E7HA 2BXMA 1HK3A 2VDBA 2XVUA 2VUFA 4F5UA 3JQZA 4N0FD 1BKEA 1UORA 1BJ5A 4S1YA 2BXAA 4F5TA 4F5VA 2BXEA 5IIXA 5IJ5A 1GNJA 4HGKA 2XVWA 1E7AA 1HK4A 1KW2A 3JRYA 2BXOA 4ZBQA 4Z69A
chains in the Genus database with same CATH superfamily
2DYMA 3FNMA 1J78A 1HA2A 1E7BA 3SQJA 1GNIA 2OT3A 4GDLB 2ROHA 2Z8KA 2VUEA 4D7XA 2QHBA 2DBXA 4IW2A 2QMCA 4LB2A 1AO6A 3LU6A 5GIOA 3LU8A 4N3ZA 4ZUXV 1SB0A 4GDXA 3NVMA 4L8UA 2NNWA 3UIVA 1H5WA 1E7CA 4M70B 4PO0A 2BXPA 3B9MA 4OT2A 4OTTA 3FWCC 4J2VA 2BXNA 3TDLA 5FUOA 4JK4A 2GUTA 1LOTA 2BXCA 4LB9A 5IJFA 2BXKA 4GDKB 4GG2A 5IJEA 1MM8A 2I30A 2BXGA 3SIUB 2I2ZA 5IFOA 3GA9L 2LQIA 5GIPA 2OZBB 2XW0A 4LUHA 4LUFA 1NT2B 1JNBA 3GQUA 4FK5B 3B9LA 2EFDA 2E0YA 2EFHA 4L9KA 5IIHA 3JRYA 2XVVA 2DG5A 4MBEC 2JUHA 1BM0A 1HK2A 1FOUA 1O9XA 3GQXA 3A73A 4ZC6A 3M99C 5IIUA 1MIVA 3ECPA 5DBYA 3SIVB 3MHHB 1HK1A 1TF0A 3BPJA 4K2CA 1MUSA 4L9QA 4LA0A 5GHKA 4BY9C 2XVQA 4FIPB 4F5SA 3H37A 5B5TA 4ZBRA 1KXPD 2BXLA 2DBWA 3V03A 4OR0A 5GINA 3A75A 2Z8JA 4IW1A 2KBZA 4BKEA 2YDFA 4HGMB 1VFIA 4G04A 2BX8A 2XSIA 3WHQA 5ID9A 1E7GA 4ZBKA 4NAWB 2Z8IA 4G01A 2LXSA 2KWFA 1E7IA 1MIYA 3KJLA 2XMOA 5HOZA 1TXUA 5D7GA 2BXIA 3V09A 4N0UD 1E78A 4DHXB 2BXDA 4G03A 1E7EA 2AGHB 4K71A 2BXFA 3W1SA 2LXTA 3LU7A 1LNSA 1MA9A 3V08A 1H9ZA 1HK5A 1E7FA 5DQFA 2BXQA 3WHSA 4E99A 2BXHA 1N5UA 2V36A 2XW1A 4TQ1A 5ID7A 4DM0A 2EFCA 1VZSA 2DBUA 3CX9A 4EMXA 4Z69A 2BXBA 3NVIA 1J7EA 1KDXA 1E7HA 4ZCGA 2BXMA 2K0NA 1HK3A 4C31B 2VDBA 2XVUA 2VUFA 3MHSB 2CKXA 4F5UA 3JQZA 4I9OA 2LOQA 4FJCB 4N0FD 3WHRA 3NMUA 4WA6B 3VQIA 1BKEA 1UORA 1IJGA 1BJ5A 1MIWA 2BXAA 3H3AA 3G9KD 4S1YA 2NQOA 4F5TA 1MUHA 2DYOA 4F5VA 2E0XA 3KIKA 4Z9OA 4TQ0A 3NVKA 2QM6A 2BXEA 3ICXA 5IJ5A 5IIXA 2LQHA 3PLAA 1GNJA 4OTUA 2EFEA 2AJEA 4HGKA 5BPKA 2XVWA 1E7AA 1HK4A 1KW2A 2BXOA 3FWBC 4ZBQA 4W4UB
chains in the Genus database with same CATH topology
2DYMA 3FNMA 1J78A 1HA2A 1E7BA 3SQJA 1GNIA 2OT3A 4GDLB 2ROHA 2Z8KA 2VUEA 2QHBA 2DBXA 4IW2A 2QMCA 4LB2A 1AO6A 3LU6A 5GIOA 3LU8A 4N3ZA 4ZUXV 4GDXA 3NVMA 4L8UA 2NNWA 3UIVA 1H5WA 1E7CA 4M70B 4PO0A 2BXPA 3B9MA 4OT2A 4OTTA 3FWCC 4J2VA 2BXNA 3TDLA 5FUOA 4JK4A 1LOTA 2BXCA 4LB9A 5IJFA 2BXKA 4GDKB 4GG2A 5IJEA 2I30A 2BXGA 3SIUB 2I2ZA 5IFOA 3GA9L 5GIPA 2OZBB 2XW0A 4LUHA 4LUFA 1NT2B 1JNBA 3GQUA 4FK5B 3B9LA 2EFDA 2E0YA 2EFHA 4L9KA 5IIHA 3JRYA 2XVVA 2DG5A 4MBEC 2JUHA 1BM0A 1HK2A 1FOUA 1O9XA 3GQXA 3A73A 4ZC6A 3M99C 5IIUA 1MIVA 5DBYA 3SIVB 3MHHB 1HK1A 1TF0A 4K2CA 4L9QA 4LA0A 5GHKA 4BY9C 2XVQA 4FIPB 4F5SA 3H37A 5B5TA 4ZBRA 1KXPD 2BXLA 2DBWA 3V03A 4OR0A 5GINA 3A75A 2Z8JA 4IW1A 2KBZA 4BKEA 2YDFA 4HGMB 1VFIA 4G04A 2BX8A 2XSIA 3WHQA 5ID9A 1E7GA 4ZBKA 4NAWB 2Z8IA 4G01A 1E7IA 1MIYA 3KJLA 2XMOA 5HOZA 1TXUA 5D7GA 2BXIA 3V09A 4N0UD 1E78A 4DHXB 2BXDA 4G03A 1E7EA 4K71A 2BXFA 3W1SA 3LU7A 1LNSA 1MA9A 3V08A 1H9ZA 1HK5A 1E7FA 5DQFA 2BXQA 3WHSA 4E99A 2BXHA 1N5UA 2V36A 2XW1A 4TQ1A 5ID7A 2EFCA 1VZSA 2DBUA 3CX9A 4EMXA 4Z69A 2BXBA 3NVIA 1J7EA 1E7HA 4ZCGA 2BXMA 1HK3A 4C31B 2VDBA 2XVUA 2VUFA 3MHSB 2CKXA 4F5UA 3JQZA 2LOQA 4FJCB 4N0FD 3WHRA 3NMUA 4WA6B 3VQIA 1BKEA 1UORA 1IJGA 1BJ5A 1MIWA 2BXAA 3H3AA 3G9KD 4S1YA 2NQOA 4F5TA 2DYOA 4F5VA 2E0XA 3KIKA 4Z9OA 4TQ0A 3NVKA 2QM6A 2BXEA 3ICXA 5IJ5A 5IIXA 3PLAA 1GNJA 4OTUA 2EFEA 2AJEA 4HGKA 5BPKA 2XVWA 1E7AA 1HK4A 1KW2A 2BXOA 3FWBC 4ZBQA 4W4UB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1J78 A;  1HA2 A;  1E7B A;  3SQJ A;  1GNI A;  2VUE A;  4IW2 A;  4LB2 A;  1AO6 A;  3LU6 A;  3LU8 A;  4L8U A;  3UIV A;  1E7C A;  4PO0 A;  2BXP A;  3B9M A;  4OT2 A;  4J2V A;  2BXN A;  3TDL A;  5FUO A;  4JK4 A;  1LOT A;  2BXC A;  4LB9 A;  5IJF A;  2BXK A;  5IJE A;  2I30 A;  2BXG A;  2I2Z A;  5IFO A;  2XW0 A;  4LUH A;  4LUF A;  3B9L A;  4L9K A;  5IIH A;  2XVV A;  1BM0 A;  1HK2 A;  1O9X A;  3A73 A;  5IIU A;  5DBY A;  1HK1 A;  1TF0 A;  4K2C A;  4L9Q A;  4LA0 A;  5GHK A;  2XVQ A;  4F5S A;  4ZBR A;  1KXP D;  2BXL A;  3V03 A;  4OR0 A;  4IW1 A;  4BKE A;  2YDF A;  4HGM B;  4G04 A;  2BX8 A;  2XSI A;  5ID9 A;  1E7G A;  1E7I A;  5HOZ A;  2BXI A;  3V09 A;  4N0U D;  1E78 A;  2BXD A;  4G03 A;  1E7E A;  4K71 A;  2BXF A;  3LU7 A;  3V08 A;  1MA9 A;  1H9Z A;  1HK5 A;  1E7F A;  5DQF A;  2BXQ A;  4E99 A;  2BXH A;  1N5U A;  2XW1 A;  5ID7 A;  3CX9 A;  4EMX A;  2BXB A;  1J7E A;  1E7H A;  2BXM A;  1HK3 A;  2VDB A;  2XVU A;  2VUF A;  4F5U A;  3JQZ A;  4N0F D;  1BKE A;  1UOR A;  1BJ5 A;  4S1Y A;  2BXA A;  4F5T A;  4F5V A;  2BXE A;  5IIX A;  5IJ5 A;  1GNJ A;  4HGK A;  2XVW A;  1E7A A;  1HK4 A;  1KW2 A;  3JRY A;  2BXO A;  4ZBQ A;  4Z69 A; 
#chains in the Genus database with same CATH topology
 2DYM A;  3FNM A;  1J78 A;  1HA2 A;  1E7B A;  3SQJ A;  1GNI A;  2OT3 A;  4GDL B;  2ROH A;  2Z8K A;  2VUE A;  4D7X A;  2QHB A;  2DBX A;  4IW2 A;  2QMC A;  4LB2 A;  1AO6 A;  3LU6 A;  5GIO A;  3LU8 A;  4N3Z A;  4ZUX V;  1SB0 A;  4GDX A;  3NVM A;  4L8U A;  2NNW A;  3UIV A;  1H5W A;  1E7C A;  4M70 B;  4PO0 A;  2BXP A;  3B9M A;  4OT2 A;  4OTT A;  3FWC C;  4J2V A;  2BXN A;  3TDL A;  5FUO A;  4JK4 A;  2GUT A;  1LOT A;  2BXC A;  4LB9 A;  5IJF A;  2BXK A;  4GDK B;  4GG2 A;  5IJE A;  1MM8 A;  2I30 A;  2BXG A;  3SIU B;  2I2Z A;  5IFO A;  3GA9 L;  2LQI A;  5GIP A;  2OZB B;  2XW0 A;  4LUH A;  4LUF A;  1NT2 B;  1JNB A;  3GQU A;  4FK5 B;  3B9L A;  2EFD A;  2E0Y A;  2EFH A;  4L9K A;  5IIH A;  3JRY A;  2XVV A;  2DG5 A;  4MBE C;  2JUH A;  1BM0 A;  1HK2 A;  1FOU A;  1O9X A;  3GQX A;  3A73 A;  4ZC6 A;  3M99 C;  5IIU A;  1MIV A;  3ECP A;  5DBY A;  3SIV B;  3MHH B;  1HK1 A;  1TF0 A;  3BPJ A;  4K2C A;  1MUS A;  4L9Q A;  4LA0 A;  5GHK A;  4BY9 C;  2XVQ A;  4FIP B;  4F5S A;  3H37 A;  5B5T A;  4ZBR A;  1KXP D;  2BXL A;  2DBW A;  3V03 A;  4OR0 A;  5GIN A;  3A75 A;  2Z8J A;  4IW1 A;  2KBZ A;  4BKE A;  2YDF A;  4HGM B;  1VFI A;  4G04 A;  2BX8 A;  2XSI A;  3WHQ A;  5ID9 A;  1E7G A;  4ZBK A;  4NAW B;  2Z8I A;  4G01 A;  2LXS A;  2KWF A;  1E7I A;  1MIY A;  3KJL A;  2XMO A;  5HOZ A;  1TXU A;  5D7G A;  2BXI A;  3V09 A;  4N0U D;  1E78 A;  4DHX B;  2BXD A;  4G03 A;  1E7E A;  2AGH B;  4K71 A;  2BXF A;  3W1S A;  2LXT A;  3LU7 A;  1LNS A;  1MA9 A;  3V08 A;  1H9Z A;  1HK5 A;  1E7F A;  5DQF A;  2BXQ A;  3WHS A;  4E99 A;  2BXH A;  1N5U A;  2V36 A;  2XW1 A;  4TQ1 A;  5ID7 A;  4DM0 A;  2EFC A;  1VZS A;  2DBU A;  3CX9 A;  4EMX A;  4Z69 A;  2BXB A;  3NVI A;  1J7E A;  1KDX A;  1E7H A;  4ZCG A;  2BXM A;  2K0N A;  1HK3 A;  4C31 B;  2VDB A;  2XVU A;  2VUF A;  3MHS B;  2CKX A;  4F5U A;  3JQZ A;  4I9O A;  2LOQ A;  4FJC B;  4N0F D;  3WHR A;  3NMU A;  4WA6 B;  3VQI A;  1BKE A;  1UOR A;  1IJG A;  1BJ5 A;  1MIW A;  2BXA A;  3H3A A;  3G9K D;  4S1Y A;  2NQO A;  4F5T A;  1MUH A;  2DYO A;  4F5V A;  2E0X A;  3KIK A;  4Z9O A;  4TQ0 A;  3NVK A;  2QM6 A;  2BXE A;  3ICX A;  5IJ5 A;  5IIX A;  2LQH A;  3PLA A;  1GNJ A;  4OTU A;  2EFE A;  2AJE A;  4HGK A;  5BPK A;  2XVW A;  1E7A A;  1HK4 A;  1KW2 A;  2BXO A;  3FWB C;  4ZBQ A;  4W4U B; 
#chains in the Genus database with same CATH homology
 2DYM A;  3FNM A;  1J78 A;  1HA2 A;  1E7B A;  3SQJ A;  1GNI A;  2OT3 A;  4GDL B;  2ROH A;  2Z8K A;  2VUE A;  2QHB A;  2DBX A;  4IW2 A;  2QMC A;  4LB2 A;  1AO6 A;  3LU6 A;  5GIO A;  3LU8 A;  4N3Z A;  4ZUX V;  4GDX A;  3NVM A;  4L8U A;  2NNW A;  3UIV A;  1H5W A;  1E7C A;  4M70 B;  4PO0 A;  2BXP A;  3B9M A;  4OT2 A;  4OTT A;  3FWC C;  4J2V A;  2BXN A;  3TDL A;  5FUO A;  4JK4 A;  1LOT A;  2BXC A;  4LB9 A;  5IJF A;  2BXK A;  4GDK B;  4GG2 A;  5IJE A;  2I30 A;  2BXG A;  3SIU B;  2I2Z A;  5IFO A;  3GA9 L;  5GIP A;  2OZB B;  2XW0 A;  4LUH A;  4LUF A;  1NT2 B;  1JNB A;  3GQU A;  4FK5 B;  3B9L A;  2EFD A;  2E0Y A;  2EFH A;  4L9K A;  5IIH A;  3JRY A;  2XVV A;  2DG5 A;  4MBE C;  2JUH A;  1BM0 A;  1HK2 A;  1FOU A;  1O9X A;  3GQX A;  3A73 A;  4ZC6 A;  3M99 C;  5IIU A;  1MIV A;  5DBY A;  3SIV B;  3MHH B;  1HK1 A;  1TF0 A;  4K2C A;  4L9Q A;  4LA0 A;  5GHK A;  4BY9 C;  2XVQ A;  4FIP B;  4F5S A;  3H37 A;  5B5T A;  4ZBR A;  1KXP D;  2BXL A;  2DBW A;  3V03 A;  4OR0 A;  5GIN A;  3A75 A;  2Z8J A;  4IW1 A;  2KBZ A;  4BKE A;  2YDF A;  4HGM B;  1VFI A;  4G04 A;  2BX8 A;  2XSI A;  3WHQ A;  5ID9 A;  1E7G A;  4ZBK A;  4NAW B;  2Z8I A;  4G01 A;  1E7I A;  1MIY A;  3KJL A;  2XMO A;  5HOZ A;  1TXU A;  5D7G A;  2BXI A;  3V09 A;  4N0U D;  1E78 A;  4DHX B;  2BXD A;  4G03 A;  1E7E A;  4K71 A;  2BXF A;  3W1S A;  3LU7 A;  1LNS A;  1MA9 A;  3V08 A;  1H9Z A;  1HK5 A;  1E7F A;  5DQF A;  2BXQ A;  3WHS A;  4E99 A;  2BXH A;  1N5U A;  2V36 A;  2XW1 A;  4TQ1 A;  5ID7 A;  2EFC A;  1VZS A;  2DBU A;  3CX9 A;  4EMX A;  4Z69 A;  2BXB A;  3NVI A;  1J7E A;  1E7H A;  4ZCG A;  2BXM A;  1HK3 A;  4C31 B;  2VDB A;  2XVU A;  2VUF A;  3MHS B;  2CKX A;  4F5U A;  3JQZ A;  2LOQ A;  4FJC B;  4N0F D;  3WHR A;  3NMU A;  4WA6 B;  3VQI A;  1BKE A;  1UOR A;  1IJG A;  1BJ5 A;  1MIW A;  2BXA A;  3H3A A;  3G9K D;  4S1Y A;  2NQO A;  4F5T A;  2DYO A;  4F5V A;  2E0X A;  3KIK A;  4Z9O A;  4TQ0 A;  3NVK A;  2QM6 A;  2BXE A;  3ICX A;  5IJ5 A;  5IIX A;  3PLA A;  1GNJ A;  4OTU A;  2EFE A;  2AJE A;  4HGK A;  5BPK A;  2XVW A;  1E7A A;  1HK4 A;  1KW2 A;  2BXO A;  3FWB C;  4ZBQ A;  4W4U B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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