1E7AA

Crystal structure of human serum albumin complexed with the general anesthetic propofol
Total Genus 212
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
212
sequence length
578
structure length
578
Chain Sequence
SEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Binding of the General Anesthetics Propofol and Halothane to Human Serum Albumin. High Resolution Crystal Structures
pubmed doi rcsb
molecule tags Carrier protein
source organism Homo sapiens
molecule keywords SERUM ALBUMIN
total genus 212
structure length 578
sequence length 578
chains with identical sequence B
ec nomenclature
pdb deposition date 2000-08-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7aA03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7aA02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7aA04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7aA01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7aA06
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7aA05
2VUEA 4K71A 4K2CA 4LUFA 4HGKA 1E7EA 3V09A 4ZBRA 4F5TA 2BXLA 2BXBA 1BM0A 5ID9A 1E7GA 2XSIA 2I30A 2XVWA 1HK1A 2XVQA 1HK2A 4PO0A 2BXGA 2VUFA 2XVUA 1TF0A 1E7CA 1BKEA 4JK4A 3B9LA 5IJ5A 5ID7A 3LU6A 1AO6A 4G03A 4J2VA 2BXEA 4BKEA 5IIHA 1E7AA 2BXQA 2BXFA 1KW2A 5FUOA 2XVVA 5IIUA 2XW1A 3V03A 5IJFA 4F5VA 1E78A 4L9KA 3V08A 1MA9A 2BXNA 4G04A 2BX8A 4LUHA 3CX9A 4S1YA 4IW1A 4E99A 1J7EA 3JQZA 2YDFA 3LU7A 1GNIA 5DQFA 2BXKA 1HK5A 5IIXA 4HGMB 4L8UA 1GNJA 5GHKA 4ZBQA 1LOTA 4IW2A 5IFOA 1N5UA 4L9QA 2BXAA 5DBYA 3UIVA 1J78A 3SQJA 2BXIA 5IJEA 2I2ZA 1E7HA 2VDBA 1HA2A 2BXHA 3A73A 3LU8A 4F5UA 4LB2A 1KXPD 1E7BA 4LB9A 3B9MA 2BXDA 1HK3A 4LA0A 2BXMA 1UORA 1HK4A 2BXCA 2BXOA 4OT2A 4F5SA 4N0UD 1H9ZA 4OR0A 1E7IA 2BXPA 4EMXA 4N0FD 1BJ5A 4Z69A 3JRYA 5HOZA 2XW0A 1O9XA 1E7FA 3TDLA
chains in the Genus database with same CATH superfamily
2VUEA 4K71A 4K2CA 4ZC6A 2LXTA 4LUFA 4HGKA 2EFDA 1E7EA 3V09A 4I9OA 4FIPB 4ZBRA 4F5TA 2BXLA 2BXBA 2EFEA 1BM0A 3WHSA 4ZBKA 2LQHA 3WHQA 2Z8IA 4N3ZA 5ID9A 1E7GA 2ROHA 2XSIA 2QHBA 2I30A 2XVWA 1HK1A 2XVQA 1HK2A 2QM6A 4PO0A 4ZUXV 3NMUA 2EFHA 2BXGA 2VUFA 2XVUA 4FK5B 1TF0A 2Z8KA 1TXUA 2OZBB 1E7CA 2DBUA 1BKEA 4JK4A 3B9LA 3W1SA 1IJGA 2AGHB 2V36A 5IJ5A 3LU6A 5ID7A 5GIOA 3FWCC 3PLAA 3MHHB 1AO6A 4G03A 2DBXA 4G01A 2E0XA 4J2VA 3SIUB 2K0NA 2BXEA 2KBZA 4BKEA 4DM0A 2Z8JA 5IIHA 3FNMA 4Z9OA 4MBEC 3WHRA 1E7AA 5GIPA 2BXQA 3G9KD 1MIVA 4GDXA 3GQXA 2BXFA 1KW2A 5FUOA 2XVVA 5IIUA 4OTTA 2XW1A 4GDKB 3V03A 5IJFA 2LXSA 1MM8A 4F5VA 1E78A 2XMOA 1NT2B 4L9KA 3V08A 3NVIA 2LOQA 3GQUA 1MA9A 3ICXA 2BXNA 4G04A 2LQIA 2BX8A 4LUHA 4WA6B 3CX9A 4S1YA 4IW1A 4E99A 1J7EA 2AJEA 3H3AA 4TQ0A 3JQZA 2YDFA 1GNIA 2DYMA 3LU7A 5DQFA 2BXKA 1HK5A 2DG5A 3KIKA 5IIXA 3ECPA 4OTUA 1SB0A 2E0YA 1MIYA 3M99C 4HGMB 4L8UA 1GNJA 4W4UB 4ZCGA 5GHKA 2DBWA 4ZBQA 1MIWA 3BPJA 1LOTA 3KJLA 4IW2A 5IFOA 2QMCA 1N5UA 1VFIA 4L9QA 2BXAA 5DBYA 3UIVA 4DHXB 1J78A 3SQJA 2BXIA 5IJEA 2I2ZA 1VZSA 1H5WA 3GA9L 3MHSB 1E7HA 2VDBA 1HA2A 2EFCA 2BXHA 2DYOA 3A73A 3LU8A 3H37A 4F5UA 4LB2A 4GG2A 5GINA 1KXPD 4TQ1A 1E7BA 2OT3A 4LB9A 3B9MA 4BY9C 2BXDA 2CKXA 1HK3A 3FWBC 4LA0A 2BXMA 3A75A 1UORA 1HK4A 4M70B 1JNBA 5BPKA 4FJCB 1FOUA 3VQIA 2BXCA 2BXOA 3NVMA 4OT2A 4F5SA 4D7XA 4C31B 4N0UD 2GUTA 1H9ZA 4OR0A 1MUHA 2NQOA 1E7IA 2BXPA 4GDLB 4EMXA 4NAWB 3NVKA 4N0FD 2JUHA 1BJ5A 4Z69A 3SIVB 3JRYA 5HOZA 2XW0A 1KDXA 2KWFA 1O9XA 5D7GA 5B5TA 1MUSA 1E7FA 3TDLA 1LNSA 2NNWA
chains in the Genus database with same CATH topology
2VUEA 4K71A 4K2CA 4ZC6A 4LUFA 4HGKA 2EFDA 1E7EA 3V09A 4FIPB 4ZBRA 4F5TA 2BXLA 2BXBA 2EFEA 1BM0A 3WHSA 4ZBKA 3WHQA 2Z8IA 4N3ZA 5ID9A 1E7GA 2ROHA 2XSIA 2QHBA 2I30A 2XVWA 1HK1A 2XVQA 1HK2A 2QM6A 4PO0A 4ZUXV 3NMUA 2EFHA 2BXGA 2VUFA 2XVUA 4FK5B 1TF0A 2Z8KA 1TXUA 2OZBB 1E7CA 2DBUA 1BKEA 4JK4A 3B9LA 3W1SA 1IJGA 2V36A 5IJ5A 3LU6A 5ID7A 5GIOA 3FWCC 3PLAA 3MHHB 1AO6A 4G03A 2DBXA 4G01A 2E0XA 4J2VA 3SIUB 2BXEA 2KBZA 4BKEA 2Z8JA 5IIHA 3FNMA 4Z9OA 4MBEC 3WHRA 1E7AA 5GIPA 2BXQA 3G9KD 1MIVA 4GDXA 3GQXA 2BXFA 1KW2A 5FUOA 2XVVA 5IIUA 4OTTA 2XW1A 4GDKB 3V03A 5IJFA 4F5VA 1E78A 2XMOA 1NT2B 4L9KA 3V08A 3NVIA 2LOQA 3GQUA 1MA9A 3ICXA 2BXNA 4G04A 2BX8A 4LUHA 4WA6B 3CX9A 4S1YA 4IW1A 4E99A 1J7EA 2AJEA 3H3AA 4TQ0A 3JQZA 2YDFA 1GNIA 2DYMA 3LU7A 5DQFA 2BXKA 1HK5A 2DG5A 3KIKA 5IIXA 4OTUA 4HGMB 2E0YA 1MIYA 3M99C 4L8UA 1GNJA 4W4UB 4ZCGA 5GHKA 2DBWA 4ZBQA 1MIWA 1LOTA 3KJLA 4IW2A 5IFOA 2QMCA 1N5UA 1VFIA 4L9QA 2BXAA 5DBYA 3UIVA 4DHXB 1J78A 3SQJA 2BXIA 5IJEA 2I2ZA 1VZSA 1H5WA 3GA9L 3MHSB 1E7HA 2VDBA 1HA2A 2EFCA 2BXHA 2DYOA 3A73A 3LU8A 3H37A 4F5UA 4LB2A 4GG2A 5GINA 1KXPD 4TQ1A 1E7BA 2OT3A 4LB9A 3B9MA 4BY9C 2BXDA 2CKXA 1HK3A 3FWBC 4LA0A 2BXMA 3A75A 1UORA 1HK4A 4M70B 1JNBA 5BPKA 4FJCB 1FOUA 3VQIA 2BXCA 2BXOA 3NVMA 4OT2A 4F5SA 4C31B 4N0UD 1H9ZA 4OR0A 2NQOA 1E7IA 2BXPA 4GDLB 4EMXA 4NAWB 3NVKA 4N0FD 2JUHA 1BJ5A 4Z69A 3SIVB 3JRYA 5HOZA 2XW0A 1O9XA 5D7GA 5B5TA 1E7FA 3TDLA 1LNSA 2NNWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2VUE A;  4K71 A;  4K2C A;  4LUF A;  4HGK A;  1E7E A;  3V09 A;  4ZBR A;  4F5T A;  2BXL A;  2BXB A;  1BM0 A;  5ID9 A;  1E7G A;  2XSI A;  2I30 A;  2XVW A;  1HK1 A;  2XVQ A;  1HK2 A;  4PO0 A;  2BXG A;  2VUF A;  2XVU A;  1TF0 A;  1E7C A;  1BKE A;  4JK4 A;  3B9L A;  5IJ5 A;  5ID7 A;  3LU6 A;  1AO6 A;  4G03 A;  4J2V A;  2BXE A;  4BKE A;  5IIH A;  1E7A A;  2BXQ A;  2BXF A;  1KW2 A;  5FUO A;  2XVV A;  5IIU A;  2XW1 A;  3V03 A;  5IJF A;  4F5V A;  1E78 A;  4L9K A;  3V08 A;  1MA9 A;  2BXN A;  4G04 A;  2BX8 A;  4LUH A;  3CX9 A;  4S1Y A;  4IW1 A;  4E99 A;  1J7E A;  3JQZ A;  2YDF A;  3LU7 A;  1GNI A;  5DQF A;  2BXK A;  1HK5 A;  5IIX A;  4HGM B;  4L8U A;  1GNJ A;  5GHK A;  4ZBQ A;  1LOT A;  4IW2 A;  5IFO A;  1N5U A;  4L9Q A;  2BXA A;  5DBY A;  3UIV A;  1J78 A;  3SQJ A;  2BXI A;  5IJE A;  2I2Z A;  1E7H A;  2VDB A;  1HA2 A;  2BXH A;  3A73 A;  3LU8 A;  4F5U A;  4LB2 A;  1KXP D;  1E7B A;  4LB9 A;  3B9M A;  2BXD A;  1HK3 A;  4LA0 A;  2BXM A;  1UOR A;  1HK4 A;  2BXC A;  2BXO A;  4OT2 A;  4F5S A;  4N0U D;  1H9Z A;  4OR0 A;  1E7I A;  2BXP A;  4EMX A;  4N0F D;  1BJ5 A;  4Z69 A;  3JRY A;  5HOZ A;  2XW0 A;  1O9X A;  1E7F A;  3TDL A; 
#chains in the Genus database with same CATH topology
 2VUE A;  4K71 A;  4K2C A;  4ZC6 A;  2LXT A;  4LUF A;  4HGK A;  2EFD A;  1E7E A;  3V09 A;  4I9O A;  4FIP B;  4ZBR A;  4F5T A;  2BXL A;  2BXB A;  2EFE A;  1BM0 A;  3WHS A;  4ZBK A;  2LQH A;  3WHQ A;  2Z8I A;  4N3Z A;  5ID9 A;  1E7G A;  2ROH A;  2XSI A;  2QHB A;  2I30 A;  2XVW A;  1HK1 A;  2XVQ A;  1HK2 A;  2QM6 A;  4PO0 A;  4ZUX V;  3NMU A;  2EFH A;  2BXG A;  2VUF A;  2XVU A;  4FK5 B;  1TF0 A;  2Z8K A;  1TXU A;  2OZB B;  1E7C A;  2DBU A;  1BKE A;  4JK4 A;  3B9L A;  3W1S A;  1IJG A;  2AGH B;  2V36 A;  5IJ5 A;  3LU6 A;  5ID7 A;  5GIO A;  3FWC C;  3PLA A;  3MHH B;  1AO6 A;  4G03 A;  2DBX A;  4G01 A;  2E0X A;  4J2V A;  3SIU B;  2K0N A;  2BXE A;  2KBZ A;  4BKE A;  4DM0 A;  2Z8J A;  5IIH A;  3FNM A;  4Z9O A;  4MBE C;  3WHR A;  1E7A A;  5GIP A;  2BXQ A;  3G9K D;  1MIV A;  4GDX A;  3GQX A;  2BXF A;  1KW2 A;  5FUO A;  2XVV A;  5IIU A;  4OTT A;  2XW1 A;  4GDK B;  3V03 A;  5IJF A;  2LXS A;  1MM8 A;  4F5V A;  1E78 A;  2XMO A;  1NT2 B;  4L9K A;  3V08 A;  3NVI A;  2LOQ A;  3GQU A;  1MA9 A;  3ICX A;  2BXN A;  4G04 A;  2LQI A;  2BX8 A;  4LUH A;  4WA6 B;  3CX9 A;  4S1Y A;  4IW1 A;  4E99 A;  1J7E A;  2AJE A;  3H3A A;  4TQ0 A;  3JQZ A;  2YDF A;  1GNI A;  2DYM A;  3LU7 A;  5DQF A;  2BXK A;  1HK5 A;  2DG5 A;  3KIK A;  5IIX A;  3ECP A;  4OTU A;  1SB0 A;  2E0Y A;  1MIY A;  3M99 C;  4HGM B;  4L8U A;  1GNJ A;  4W4U B;  4ZCG A;  5GHK A;  2DBW A;  4ZBQ A;  1MIW A;  3BPJ A;  1LOT A;  3KJL A;  4IW2 A;  5IFO A;  2QMC A;  1N5U A;  1VFI A;  4L9Q A;  2BXA A;  5DBY A;  3UIV A;  4DHX B;  1J78 A;  3SQJ A;  2BXI A;  5IJE A;  2I2Z A;  1VZS A;  1H5W A;  3GA9 L;  3MHS B;  1E7H A;  2VDB A;  1HA2 A;  2EFC A;  2BXH A;  2DYO A;  3A73 A;  3LU8 A;  3H37 A;  4F5U A;  4LB2 A;  4GG2 A;  5GIN A;  1KXP D;  4TQ1 A;  1E7B A;  2OT3 A;  4LB9 A;  3B9M A;  4BY9 C;  2BXD A;  2CKX A;  1HK3 A;  3FWB C;  4LA0 A;  2BXM A;  3A75 A;  1UOR A;  1HK4 A;  4M70 B;  1JNB A;  5BPK A;  4FJC B;  1FOU A;  3VQI A;  2BXC A;  2BXO A;  3NVM A;  4OT2 A;  4F5S A;  4D7X A;  4C31 B;  4N0U D;  2GUT A;  1H9Z A;  4OR0 A;  1MUH A;  2NQO A;  1E7I A;  2BXP A;  4GDL B;  4EMX A;  4NAW B;  3NVK A;  4N0F D;  2JUH A;  1BJ5 A;  4Z69 A;  3SIV B;  3JRY A;  5HOZ A;  2XW0 A;  1KDX A;  2KWF A;  1O9X A;  5D7G A;  5B5T A;  1MUS A;  1E7F A;  3TDL A;  1LNS A;  2NNW A; 
#chains in the Genus database with same CATH homology
 2VUE A;  4K71 A;  4K2C A;  4ZC6 A;  4LUF A;  4HGK A;  2EFD A;  1E7E A;  3V09 A;  4FIP B;  4ZBR A;  4F5T A;  2BXL A;  2BXB A;  2EFE A;  1BM0 A;  3WHS A;  4ZBK A;  3WHQ A;  2Z8I A;  4N3Z A;  5ID9 A;  1E7G A;  2ROH A;  2XSI A;  2QHB A;  2I30 A;  2XVW A;  1HK1 A;  2XVQ A;  1HK2 A;  2QM6 A;  4PO0 A;  4ZUX V;  3NMU A;  2EFH A;  2BXG A;  2VUF A;  2XVU A;  4FK5 B;  1TF0 A;  2Z8K A;  1TXU A;  2OZB B;  1E7C A;  2DBU A;  1BKE A;  4JK4 A;  3B9L A;  3W1S A;  1IJG A;  2V36 A;  5IJ5 A;  3LU6 A;  5ID7 A;  5GIO A;  3FWC C;  3PLA A;  3MHH B;  1AO6 A;  4G03 A;  2DBX A;  4G01 A;  2E0X A;  4J2V A;  3SIU B;  2BXE A;  2KBZ A;  4BKE A;  2Z8J A;  5IIH A;  3FNM A;  4Z9O A;  4MBE C;  3WHR A;  1E7A A;  5GIP A;  2BXQ A;  3G9K D;  1MIV A;  4GDX A;  3GQX A;  2BXF A;  1KW2 A;  5FUO A;  2XVV A;  5IIU A;  4OTT A;  2XW1 A;  4GDK B;  3V03 A;  5IJF A;  4F5V A;  1E78 A;  2XMO A;  1NT2 B;  4L9K A;  3V08 A;  3NVI A;  2LOQ A;  3GQU A;  1MA9 A;  3ICX A;  2BXN A;  4G04 A;  2BX8 A;  4LUH A;  4WA6 B;  3CX9 A;  4S1Y A;  4IW1 A;  4E99 A;  1J7E A;  2AJE A;  3H3A A;  4TQ0 A;  3JQZ A;  2YDF A;  1GNI A;  2DYM A;  3LU7 A;  5DQF A;  2BXK A;  1HK5 A;  2DG5 A;  3KIK A;  5IIX A;  4OTU A;  4HGM B;  2E0Y A;  1MIY A;  3M99 C;  4L8U A;  1GNJ A;  4W4U B;  4ZCG A;  5GHK A;  2DBW A;  4ZBQ A;  1MIW A;  1LOT A;  3KJL A;  4IW2 A;  5IFO A;  2QMC A;  1N5U A;  1VFI A;  4L9Q A;  2BXA A;  5DBY A;  3UIV A;  4DHX B;  1J78 A;  3SQJ A;  2BXI A;  5IJE A;  2I2Z A;  1VZS A;  1H5W A;  3GA9 L;  3MHS B;  1E7H A;  2VDB A;  1HA2 A;  2EFC A;  2BXH A;  2DYO A;  3A73 A;  3LU8 A;  3H37 A;  4F5U A;  4LB2 A;  4GG2 A;  5GIN A;  1KXP D;  4TQ1 A;  1E7B A;  2OT3 A;  4LB9 A;  3B9M A;  4BY9 C;  2BXD A;  2CKX A;  1HK3 A;  3FWB C;  4LA0 A;  2BXM A;  3A75 A;  1UOR A;  1HK4 A;  4M70 B;  1JNB A;  5BPK A;  4FJC B;  1FOU A;  3VQI A;  2BXC A;  2BXO A;  3NVM A;  4OT2 A;  4F5S A;  4C31 B;  4N0U D;  1H9Z A;  4OR0 A;  2NQO A;  1E7I A;  2BXP A;  4GDL B;  4EMX A;  4NAW B;  3NVK A;  4N0F D;  2JUH A;  1BJ5 A;  4Z69 A;  3SIV B;  3JRY A;  5HOZ A;  2XW0 A;  1O9X A;  5D7G A;  5B5T A;  1E7F A;  3TDL A;  1LNS A;  2NNW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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