1E7BA

Crystal structure of human serum albumin complexed with the general anesthetic halothane
Total Genus 197
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
197
sequence length
578
structure length
578
Chain Sequence
SEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Binding of the General Anesthetics Propofol and Halothane to Human Serum Albumin. High Resolution Crystal Structures
pubmed doi rcsb
molecule tags Carrier protein
source organism Homo sapiens
molecule keywords SERUM ALBUMIN
total genus 197
structure length 578
sequence length 578
chains with identical sequence B
ec nomenclature
pdb deposition date 2000-08-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7bA03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7bA02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7bA04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7bA01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7bA06
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1e7bA05
4J2VA 4LB2A 4K2CA 5IJFA 1HK1A 4PO0A 2BX8A 2BXPA 1HK4A 1UORA 4LA0A 4IW2A 4OT2A 5FUOA 1E7HA 5ID9A 2YDFA 4BKEA 4ZBRA 2XVWA 4HGKA 2BXKA 4S1YA 4F5SA 3JRYA 4LUFA 5DQFA 1H9ZA 4G03A 1E7GA 3LU7A 4OR0A 5IFOA 4Z69A 5IJEA 1HA2A 4E99A 3LU6A 1E7EA 2BXQA 4HGMB 1O9XA 2BXLA 1MA9A 1HK5A 3V09A 2I30A 1GNIA 3B9LA 1E7FA 2VUFA 1BM0A 2BXHA 4ZBQA 4N0FD 5GHKA 2BXAA 2BXNA 5DBYA 5IJ5A 4F5UA 1TF0A 2BXGA 3UIVA 2XVUA 2VUEA 3SQJA 4F5VA 4JK4A 2I2ZA 4IW1A 3B9MA 2XSIA 1KXPD 2XVQA 1HK2A 1AO6A 5IIXA 1BKEA 2XVVA 1E7IA 5IIUA 2BXEA 3LU8A 4EMXA 2VDBA 4LUHA 1GNJA 5ID7A 2BXOA 2BXCA 5HOZA 1N5UA 4K71A 4L9KA 2BXMA 2XW1A 3JQZA 4G04A 4LB9A 2BXFA 1BJ5A 4F5TA 4L8UA 1E78A 2XW0A 4N0UD 1J7EA 2BXBA 3V08A 5IIHA 1HK3A 1J78A 2BXDA 3TDLA 1E7BA 1E7CA 2BXIA 1LOTA 3CX9A 1E7AA 1KW2A 3V03A 3A73A 4L9QA
chains in the Genus database with same CATH superfamily
4J2VA 4LB2A 2EFDA 4TQ1A 4K2CA 5IJFA 1HK1A 4PO0A 4Z9OA 2BX8A 2BXPA 1TXUA 4GDLB 1IJGA 1HK4A 2DBWA 2DYOA 1NT2B 1UORA 2LXSA 2Z8IA 4IW2A 4LA0A 4OT2A 5FUOA 4C31B 1E7HA 5ID9A 2YDFA 2Z8JA 4BKEA 4ZBRA 2XVWA 4HGKA 2K0NA 2BXKA 1MIVA 4S1YA 2DBXA 3JRYA 4F5SA 4LUFA 5DQFA 1H9ZA 4G03A 1E7GA 3LU7A 4OR0A 5IFOA 4D7XA 4Z69A 5IJEA 5GIOA 1HA2A 2DBUA 3NVKA 2LOQA 5B5TA 2NQOA 2NNWA 4E99A 3LU6A 1E7EA 5BPKA 2AJEA 4WA6B 2QHBA 4ZUXV 2BXQA 2EFHA 1O9XA 2BXLA 4HGMB 5GINA 1MA9A 1HK5A 2KBZA 2LQIA 4W4UB 3V09A 2I30A 3NMUA 1GNIA 3KIKA 4MBEC 3SIUB 2Z8KA 3B9LA 1E7FA 4GDXA 2OZBB 2VUFA 1BM0A 5D7GA 2QM6A 2BXHA 1VFIA 4N0FD 4ZBQA 3M99C 5GHKA 2BXAA 2BXNA 3WHQA 3GQUA 5DBYA 3GQXA 4ZC6A 3FNMA 4GDKB 5IJ5A 2E0YA 1TF0A 4F5UA 3NVMA 2BXGA 3UIVA 2XVUA 2VUEA 3FWCC 3PLAA 3SQJA 1KDXA 4F5VA 4JK4A 3W1SA 2I2ZA 4IW1A 3B9MA 3BPJA 3H37A 2XSIA 4G01A 4DHXB 1MUHA 1KXPD 2XVQA 2CKXA 1HK2A 1AO6A 4GG2A 4FK5B 5IIXA 3H3AA 1BKEA 2XVVA 2KWFA 1E7IA 3GA9L 4OTUA 4M70B 5IIUA 3SIVB 4ZCGA 2GUTA 4DM0A 2BXEA 3LU8A 2E0XA 4EMXA 3KJLA 4TQ0A 2VDBA 2ROHA 4FIPB 5GIPA 4LUHA 1GNJA 4N3ZA 2LXTA 5ID7A 3FWBC 2DG5A 2BXOA 2DYMA 3WHRA 2BXCA 3ICXA 4OTTA 4ZBKA 2LQHA 1SB0A 5HOZA 1N5UA 3MHHB 3G9KD 4K71A 4L9KA 2BXMA 3MHSB 1MIWA 2XW1A 1MUSA 3NVIA 3JQZA 2EFCA 4G04A 4LB9A 3WHSA 1MM8A 2BXFA 4I9OA 1BJ5A 2XMOA 4F5TA 2AGHB 3ECPA 4BY9C 4L8UA 1E78A 2V36A 2XW0A 2OT3A 4N0UD 4FJCB 1H5WA 1VZSA 1JNBA 1J7EA 2BXBA 3V08A 5IIHA 1FOUA 1HK3A 1J78A 2BXDA 2QMCA 3TDLA 1E7BA 1MIYA 1E7CA 2EFEA 3A75A 2JUHA 3VQIA 2BXIA 4NAWB 1LOTA 3CX9A 1E7AA 1KW2A 3V03A 3A73A 4L9QA 1LNSA
chains in the Genus database with same CATH topology
4J2VA 4LB2A 2EFDA 4TQ1A 4K2CA 5IJFA 1HK1A 4PO0A 4Z9OA 2BX8A 2BXPA 1TXUA 4GDLB 1IJGA 1HK4A 2DBWA 2DYOA 1NT2B 1UORA 2Z8IA 4IW2A 4LA0A 4OT2A 5FUOA 4C31B 1E7HA 5ID9A 2YDFA 2Z8JA 4BKEA 4ZBRA 2XVWA 4HGKA 2BXKA 1MIVA 4S1YA 2DBXA 3JRYA 4F5SA 4LUFA 5DQFA 1H9ZA 4G03A 1E7GA 3LU7A 4OR0A 5IFOA 4Z69A 5IJEA 5GIOA 1HA2A 2DBUA 3NVKA 2LOQA 5B5TA 2NQOA 2NNWA 4E99A 3LU6A 1E7EA 5BPKA 2AJEA 4WA6B 2QHBA 4ZUXV 2BXQA 2EFHA 1O9XA 2BXLA 4HGMB 5GINA 1MA9A 1HK5A 2KBZA 4W4UB 3V09A 2I30A 3NMUA 1GNIA 3KIKA 4MBEC 3SIUB 2Z8KA 3B9LA 1E7FA 4GDXA 2OZBB 2VUFA 1BM0A 5D7GA 2QM6A 2BXHA 1VFIA 4N0FD 4ZBQA 3M99C 5GHKA 2BXAA 2BXNA 3WHQA 3GQUA 5DBYA 3GQXA 4ZC6A 3FNMA 4GDKB 5IJ5A 2E0YA 1TF0A 4F5UA 3NVMA 2BXGA 3UIVA 2XVUA 2VUEA 3FWCC 3PLAA 3SQJA 4F5VA 4JK4A 3W1SA 2I2ZA 4IW1A 3B9MA 3H37A 2XSIA 4G01A 4DHXB 1KXPD 2XVQA 2CKXA 1HK2A 1AO6A 4GG2A 4FK5B 5IIXA 3H3AA 1BKEA 2XVVA 1E7IA 3GA9L 4OTUA 4M70B 5IIUA 3SIVB 4ZCGA 2BXEA 3LU8A 2E0XA 4EMXA 3KJLA 4TQ0A 2VDBA 2ROHA 4FIPB 5GIPA 4LUHA 1GNJA 4N3ZA 5ID7A 3FWBC 2DG5A 2BXOA 2DYMA 3WHRA 2BXCA 3ICXA 4OTTA 4ZBKA 5HOZA 1N5UA 3MHHB 3G9KD 4K71A 4L9KA 2BXMA 3MHSB 1MIWA 2XW1A 3NVIA 3JQZA 2EFCA 4G04A 4LB9A 3WHSA 2BXFA 1BJ5A 2XMOA 4F5TA 4BY9C 4L8UA 1E78A 2V36A 2XW0A 2OT3A 4N0UD 4FJCB 1H5WA 1VZSA 1JNBA 1J7EA 2BXBA 3V08A 5IIHA 1FOUA 1HK3A 1J78A 2BXDA 2QMCA 3TDLA 1E7BA 1MIYA 1E7CA 2EFEA 3A75A 2JUHA 3VQIA 2BXIA 4NAWB 1LOTA 3CX9A 1E7AA 1KW2A 3V03A 3A73A 4L9QA 1LNSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4J2V A;  4LB2 A;  4K2C A;  5IJF A;  1HK1 A;  4PO0 A;  2BX8 A;  2BXP A;  1HK4 A;  1UOR A;  4LA0 A;  4IW2 A;  4OT2 A;  5FUO A;  1E7H A;  5ID9 A;  2YDF A;  4BKE A;  4ZBR A;  2XVW A;  4HGK A;  2BXK A;  4S1Y A;  4F5S A;  3JRY A;  4LUF A;  5DQF A;  1H9Z A;  4G03 A;  1E7G A;  3LU7 A;  4OR0 A;  5IFO A;  4Z69 A;  5IJE A;  1HA2 A;  4E99 A;  3LU6 A;  1E7E A;  2BXQ A;  4HGM B;  1O9X A;  2BXL A;  1MA9 A;  1HK5 A;  3V09 A;  2I30 A;  1GNI A;  3B9L A;  1E7F A;  2VUF A;  1BM0 A;  2BXH A;  4ZBQ A;  4N0F D;  5GHK A;  2BXA A;  2BXN A;  5DBY A;  5IJ5 A;  4F5U A;  1TF0 A;  2BXG A;  3UIV A;  2XVU A;  2VUE A;  3SQJ A;  4F5V A;  4JK4 A;  2I2Z A;  4IW1 A;  3B9M A;  2XSI A;  1KXP D;  2XVQ A;  1HK2 A;  1AO6 A;  5IIX A;  1BKE A;  2XVV A;  1E7I A;  5IIU A;  2BXE A;  3LU8 A;  4EMX A;  2VDB A;  4LUH A;  1GNJ A;  5ID7 A;  2BXO A;  2BXC A;  5HOZ A;  1N5U A;  4K71 A;  4L9K A;  2BXM A;  2XW1 A;  3JQZ A;  4G04 A;  4LB9 A;  2BXF A;  1BJ5 A;  4F5T A;  4L8U A;  1E78 A;  2XW0 A;  4N0U D;  1J7E A;  2BXB A;  3V08 A;  5IIH A;  1HK3 A;  1J78 A;  2BXD A;  3TDL A;  1E7B A;  1E7C A;  2BXI A;  1LOT A;  3CX9 A;  1E7A A;  1KW2 A;  3V03 A;  3A73 A;  4L9Q A; 
#chains in the Genus database with same CATH topology
 4J2V A;  4LB2 A;  2EFD A;  4TQ1 A;  4K2C A;  5IJF A;  1HK1 A;  4PO0 A;  4Z9O A;  2BX8 A;  2BXP A;  1TXU A;  4GDL B;  1IJG A;  1HK4 A;  2DBW A;  2DYO A;  1NT2 B;  1UOR A;  2LXS A;  2Z8I A;  4IW2 A;  4LA0 A;  4OT2 A;  5FUO A;  4C31 B;  1E7H A;  5ID9 A;  2YDF A;  2Z8J A;  4BKE A;  4ZBR A;  2XVW A;  4HGK A;  2K0N A;  2BXK A;  1MIV A;  4S1Y A;  2DBX A;  3JRY A;  4F5S A;  4LUF A;  5DQF A;  1H9Z A;  4G03 A;  1E7G A;  3LU7 A;  4OR0 A;  5IFO A;  4D7X A;  4Z69 A;  5IJE A;  5GIO A;  1HA2 A;  2DBU A;  3NVK A;  2LOQ A;  5B5T A;  2NQO A;  2NNW A;  4E99 A;  3LU6 A;  1E7E A;  5BPK A;  2AJE A;  4WA6 B;  2QHB A;  4ZUX V;  2BXQ A;  2EFH A;  1O9X A;  2BXL A;  4HGM B;  5GIN A;  1MA9 A;  1HK5 A;  2KBZ A;  2LQI A;  4W4U B;  3V09 A;  2I30 A;  3NMU A;  1GNI A;  3KIK A;  4MBE C;  3SIU B;  2Z8K A;  3B9L A;  1E7F A;  4GDX A;  2OZB B;  2VUF A;  1BM0 A;  5D7G A;  2QM6 A;  2BXH A;  1VFI A;  4N0F D;  4ZBQ A;  3M99 C;  5GHK A;  2BXA A;  2BXN A;  3WHQ A;  3GQU A;  5DBY A;  3GQX A;  4ZC6 A;  3FNM A;  4GDK B;  5IJ5 A;  2E0Y A;  1TF0 A;  4F5U A;  3NVM A;  2BXG A;  3UIV A;  2XVU A;  2VUE A;  3FWC C;  3PLA A;  3SQJ A;  1KDX A;  4F5V A;  4JK4 A;  3W1S A;  2I2Z A;  4IW1 A;  3B9M A;  3BPJ A;  3H37 A;  2XSI A;  4G01 A;  4DHX B;  1MUH A;  1KXP D;  2XVQ A;  2CKX A;  1HK2 A;  1AO6 A;  4GG2 A;  4FK5 B;  5IIX A;  3H3A A;  1BKE A;  2XVV A;  2KWF A;  1E7I A;  3GA9 L;  4OTU A;  4M70 B;  5IIU A;  3SIV B;  4ZCG A;  2GUT A;  4DM0 A;  2BXE A;  3LU8 A;  2E0X A;  4EMX A;  3KJL A;  4TQ0 A;  2VDB A;  2ROH A;  4FIP B;  5GIP A;  4LUH A;  1GNJ A;  4N3Z A;  2LXT A;  5ID7 A;  3FWB C;  2DG5 A;  2BXO A;  2DYM A;  3WHR A;  2BXC A;  3ICX A;  4OTT A;  4ZBK A;  2LQH A;  1SB0 A;  5HOZ A;  1N5U A;  3MHH B;  3G9K D;  4K71 A;  4L9K A;  2BXM A;  3MHS B;  1MIW A;  2XW1 A;  1MUS A;  3NVI A;  3JQZ A;  2EFC A;  4G04 A;  4LB9 A;  3WHS A;  1MM8 A;  2BXF A;  4I9O A;  1BJ5 A;  2XMO A;  4F5T A;  2AGH B;  3ECP A;  4BY9 C;  4L8U A;  1E78 A;  2V36 A;  2XW0 A;  2OT3 A;  4N0U D;  4FJC B;  1H5W A;  1VZS A;  1JNB A;  1J7E A;  2BXB A;  3V08 A;  5IIH A;  1FOU A;  1HK3 A;  1J78 A;  2BXD A;  2QMC A;  3TDL A;  1E7B A;  1MIY A;  1E7C A;  2EFE A;  3A75 A;  2JUH A;  3VQI A;  2BXI A;  4NAW B;  1LOT A;  3CX9 A;  1E7A A;  1KW2 A;  3V03 A;  3A73 A;  4L9Q A;  1LNS A; 
#chains in the Genus database with same CATH homology
 4J2V A;  4LB2 A;  2EFD A;  4TQ1 A;  4K2C A;  5IJF A;  1HK1 A;  4PO0 A;  4Z9O A;  2BX8 A;  2BXP A;  1TXU A;  4GDL B;  1IJG A;  1HK4 A;  2DBW A;  2DYO A;  1NT2 B;  1UOR A;  2Z8I A;  4IW2 A;  4LA0 A;  4OT2 A;  5FUO A;  4C31 B;  1E7H A;  5ID9 A;  2YDF A;  2Z8J A;  4BKE A;  4ZBR A;  2XVW A;  4HGK A;  2BXK A;  1MIV A;  4S1Y A;  2DBX A;  3JRY A;  4F5S A;  4LUF A;  5DQF A;  1H9Z A;  4G03 A;  1E7G A;  3LU7 A;  4OR0 A;  5IFO A;  4Z69 A;  5IJE A;  5GIO A;  1HA2 A;  2DBU A;  3NVK A;  2LOQ A;  5B5T A;  2NQO A;  2NNW A;  4E99 A;  3LU6 A;  1E7E A;  5BPK A;  2AJE A;  4WA6 B;  2QHB A;  4ZUX V;  2BXQ A;  2EFH A;  1O9X A;  2BXL A;  4HGM B;  5GIN A;  1MA9 A;  1HK5 A;  2KBZ A;  4W4U B;  3V09 A;  2I30 A;  3NMU A;  1GNI A;  3KIK A;  4MBE C;  3SIU B;  2Z8K A;  3B9L A;  1E7F A;  4GDX A;  2OZB B;  2VUF A;  1BM0 A;  5D7G A;  2QM6 A;  2BXH A;  1VFI A;  4N0F D;  4ZBQ A;  3M99 C;  5GHK A;  2BXA A;  2BXN A;  3WHQ A;  3GQU A;  5DBY A;  3GQX A;  4ZC6 A;  3FNM A;  4GDK B;  5IJ5 A;  2E0Y A;  1TF0 A;  4F5U A;  3NVM A;  2BXG A;  3UIV A;  2XVU A;  2VUE A;  3FWC C;  3PLA A;  3SQJ A;  4F5V A;  4JK4 A;  3W1S A;  2I2Z A;  4IW1 A;  3B9M A;  3H37 A;  2XSI A;  4G01 A;  4DHX B;  1KXP D;  2XVQ A;  2CKX A;  1HK2 A;  1AO6 A;  4GG2 A;  4FK5 B;  5IIX A;  3H3A A;  1BKE A;  2XVV A;  1E7I A;  3GA9 L;  4OTU A;  4M70 B;  5IIU A;  3SIV B;  4ZCG A;  2BXE A;  3LU8 A;  2E0X A;  4EMX A;  3KJL A;  4TQ0 A;  2VDB A;  2ROH A;  4FIP B;  5GIP A;  4LUH A;  1GNJ A;  4N3Z A;  5ID7 A;  3FWB C;  2DG5 A;  2BXO A;  2DYM A;  3WHR A;  2BXC A;  3ICX A;  4OTT A;  4ZBK A;  5HOZ A;  1N5U A;  3MHH B;  3G9K D;  4K71 A;  4L9K A;  2BXM A;  3MHS B;  1MIW A;  2XW1 A;  3NVI A;  3JQZ A;  2EFC A;  4G04 A;  4LB9 A;  3WHS A;  2BXF A;  1BJ5 A;  2XMO A;  4F5T A;  4BY9 C;  4L8U A;  1E78 A;  2V36 A;  2XW0 A;  2OT3 A;  4N0U D;  4FJC B;  1H5W A;  1VZS A;  1JNB A;  1J7E A;  2BXB A;  3V08 A;  5IIH A;  1FOU A;  1HK3 A;  1J78 A;  2BXD A;  2QMC A;  3TDL A;  1E7B A;  1MIY A;  1E7C A;  2EFE A;  3A75 A;  2JUH A;  3VQI A;  2BXI A;  4NAW B;  1LOT A;  3CX9 A;  1E7A A;  1KW2 A;  3V03 A;  3A73 A;  4L9Q A;  1LNS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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