1HA2A

Human serum albumin complexed with myristic acid and the s-(-) enantiomer of warfarin
Total Genus 222
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
222
sequence length
582
structure length
582
Chain Sequence
HKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure Analysis of Warfarin Binding to Human Serum Albumin: Anatomy of Drug Site I
pubmed doi rcsb
molecule tags Transport protein
source organism Homo sapiens
molecule keywords SERUM ALBUMIN
total genus 222
structure length 582
sequence length 582
ec nomenclature
pdb deposition date 2001-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1ha2A03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1ha2A02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1ha2A04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1ha2A01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1ha2A06
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1ha2A05
4EMXA 1J7EA 2VDBA 4IW2A 3SQJA 1AO6A 4E99A 4L8UA 2VUFA 3LU6A 2XVVA 1GNJA 4LUHA 2BXIA 1BJ5A 2BXGA 2XVUA 2BXOA 4HGMB 4Z69A 5ID9A 4JK4A 3V03A 1TF0A 2BXLA 4F5UA 1E7AA 1HK5A 1E7CA 1BM0A 4ZBRA 1E7FA 3UIVA 2BX8A 5GHKA 3TDLA 1LOTA 1E7IA 4F5TA 3A73A 1HK2A 2XVWA 4LB2A 5IJ5A 1J78A 4LB9A 1E7EA 5IFOA 5IIXA 4OR0A 3JRYA 3LU8A 1N5UA 5DBYA 1HK1A 4L9QA 2YDFA 4LUFA 4PO0A 4HGKA 2XW1A 4ZBQA 1E7HA 2BXBA 5IIUA 1HK3A 4K71A 2BXEA 2XVQA 5IIHA 1KW2A 1E78A 4LA0A 4N0FD 2BXQA 1H9ZA 4N0UD 1BKEA 1KXPD 5ID7A 5IJEA 5FUOA 4F5SA 2XSIA 1HA2A 2BXKA 4G04A 2BXAA 1E7BA 2BXDA 4IW1A 4OT2A 3V08A 2VUEA 1E7GA 2I2ZA 1HK4A 2BXFA 3V09A 1UORA 4K2CA 4J2VA 5DQFA 3LU7A 4S1YA 4F5VA 2I30A 5IJFA 1O9XA 2BXHA 3CX9A 3B9MA 5HOZA 2XW0A 2BXPA 3JQZA 3B9LA 4G03A 4L9KA 1GNIA 2BXMA 2BXCA 4BKEA 1MA9A 2BXNA
chains in the Genus database with same CATH superfamily
4EMXA 5GINA 1J7EA 2VDBA 4IW2A 4DHXB 3M99C 2QHBA 3SQJA 1H5WA 1AO6A 4E99A 4L8UA 2VUFA 4BY9C 1FOUA 3GA9L 1VZSA 2NQOA 4G01A 3LU6A 2XVVA 1GNJA 2Z8KA 4LUHA 2K0NA 2BXIA 4BKEA 1NT2B 2GUTA 1BJ5A 2BXGA 2LQIA 2XVUA 3FNMA 2KWFA 3ECPA 2AGHB 5B5TA 2JUHA 2BXOA 5BPKA 4HGMB 4Z69A 5ID9A 4JK4A 5D7GA 3BPJA 2DBXA 4N3ZA 1TF0A 3KJLA 2BXLA 4MBEC 3V03A 1E7AA 1HK5A 3WHSA 4F5UA 3NMUA 3SIUB 1MIVA 1E7CA 1BM0A 4OTTA 3GQXA 2NNWA 4D7XA 2Z8JA 4Z9OA 1E7FA 3MHSB 4ZBRA 2DYOA 3UIVA 2BX8A 5GHKA 2LXSA 3TDLA 2CKXA 1LOTA 1E7IA 4F5TA 4GG2A 3SIVB 3FWBC 3ICXA 1MUSA 3A73A 1HK2A 3VQIA 4TQ1A 2XVWA 4LB2A 5IJ5A 1J78A 1VFIA 2QMCA 4LB9A 1E7EA 5IFOA 5IIXA 2V36A 4OR0A 3JRYA 3LU8A 1N5UA 3NVKA 2AJEA 1HK1A 4GDLB 4W4UB 5DBYA 4ZC6A 3G9KD 4L9QA 1MIWA 2YDFA 4LUFA 4PO0A 2DYMA 4GDKB 4HGKA 2XW1A 4ZBQA 1E7HA 3H37A 4M70B 1MIYA 4DM0A 2LOQA 3KIKA 1JNBA 2BXBA 5IIUA 1HK3A 4FJCB 4FK5B 2BXEA 2XVQA 3GQUA 4K71A 3MHHB 5IIHA 1KW2A 1TXUA 1E78A 4LA0A 4N0FD 2BXQA 1H9ZA 4N0UD 1BKEA 1KXPD 5ID7A 2EFHA 4ZCGA 5IJEA 5FUOA 4F5SA 2DBWA 2XSIA 1HA2A 1KDXA 1SB0A 2BXKA 3A75A 4G04A 1MUHA 2BXAA 4GDXA 3NVMA 1E7BA 2BXDA 4IW1A 4OT2A 3V08A 2LXTA 2QM6A 3WHRA 4OTUA 2VUEA 1IJGA 1E7GA 3NVIA 2I2ZA 4I9OA 3W1SA 3WHQA 1HK4A 2BXFA 2KBZA 3V09A 1UORA 4FIPB 4NAWB 4WA6B 2DG5A 4ZBKA 3H3AA 2LQHA 4K2CA 5GIPA 4J2VA 5DQFA 3FWCC 3PLAA 3LU7A 4S1YA 2E0XA 4F5VA 2OT3A 2I30A 4ZUXV 2OZBB 2EFCA 2Z8IA 1LNSA 5IJFA 2EFEA 1O9XA 2BXHA 2XMOA 3CX9A 4C31B 3B9MA 2ROHA 2E0YA 5HOZA 2XW0A 2BXPA 3JQZA 3B9LA 4G03A 4L9KA 1MM8A 4TQ0A 5GIOA 1GNIA 2EFDA 2BXMA 2BXCA 2DBUA 1MA9A 2BXNA
chains in the Genus database with same CATH topology
4EMXA 5GINA 1J7EA 2VDBA 4IW2A 4DHXB 3M99C 2QHBA 3SQJA 1H5WA 1AO6A 4E99A 4L8UA 2VUFA 4BY9C 1FOUA 3GA9L 1VZSA 2NQOA 4G01A 3LU6A 2XVVA 1GNJA 2Z8KA 4LUHA 2BXIA 1NT2B 1BJ5A 2BXGA 2XVUA 3FNMA 5B5TA 2JUHA 2BXOA 4HGMB 4Z69A 5ID9A 4JK4A 5D7GA 4N3ZA 2DBXA 3V03A 1TF0A 3KJLA 2BXLA 4MBEC 3WHSA 1E7AA 1HK5A 4F5UA 3NMUA 3SIUB 1MIVA 1E7CA 1BM0A 4OTTA 3GQXA 2NNWA 2Z8JA 4Z9OA 1E7FA 3MHSB 4ZBRA 2DYOA 3UIVA 2BX8A 5GHKA 3TDLA 2CKXA 1LOTA 1E7IA 4F5TA 4GG2A 3SIVB 3FWBC 3ICXA 3A73A 1HK2A 3VQIA 4TQ1A 2XVWA 4LB2A 5IJ5A 1J78A 1VFIA 2QMCA 4LB9A 1E7EA 5IFOA 5IIXA 2V36A 4OR0A 3JRYA 3LU8A 1N5UA 3NVKA 2AJEA 1HK1A 4GDLB 4W4UB 5DBYA 4ZC6A 3G9KD 4L9QA 1MIWA 2YDFA 4LUFA 4PO0A 2DYMA 4GDKB 4HGKA 2XW1A 4ZBQA 1E7HA 3H37A 4M70B 1MIYA 2LOQA 3KIKA 1JNBA 2BXBA 5IIUA 1HK3A 4FJCB 4FK5B 2BXEA 2XVQA 3GQUA 4K71A 3MHHB 5IIHA 1KW2A 1TXUA 1E78A 4LA0A 4N0FD 2BXQA 1H9ZA 4N0UD 1BKEA 1KXPD 5ID7A 2EFHA 4ZCGA 5IJEA 5FUOA 4F5SA 2DBWA 2XSIA 1HA2A 2BXKA 3A75A 4G04A 2BXAA 4GDXA 3NVMA 1E7BA 2BXDA 4IW1A 4OT2A 3V08A 3WHRA 2QM6A 4BKEA 4OTUA 2VUEA 1IJGA 1E7GA 3NVIA 2I2ZA 3WHQA 3W1SA 5BPKA 1HK4A 2BXFA 2KBZA 3V09A 1UORA 4FIPB 4NAWB 4WA6B 2DG5A 4ZBKA 3H3AA 4K2CA 5GIPA 4J2VA 5DQFA 3FWCC 3PLAA 3LU7A 4S1YA 2E0XA 4F5VA 2OT3A 2I30A 4ZUXV 2OZBB 2EFCA 2Z8IA 1LNSA 5IJFA 2EFEA 1O9XA 2BXHA 2XMOA 3CX9A 4C31B 3B9MA 2ROHA 2E0YA 5HOZA 2XW0A 2BXPA 3JQZA 3B9LA 4G03A 4L9KA 4TQ0A 5GIOA 1GNIA 2EFDA 2BXMA 2BXCA 2DBUA 1MA9A 2BXNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4EMX A;  1J7E A;  2VDB A;  4IW2 A;  3SQJ A;  1AO6 A;  4E99 A;  4L8U A;  2VUF A;  3LU6 A;  2XVV A;  1GNJ A;  4LUH A;  2BXI A;  1BJ5 A;  2BXG A;  2XVU A;  2BXO A;  4HGM B;  4Z69 A;  5ID9 A;  4JK4 A;  3V03 A;  1TF0 A;  2BXL A;  4F5U A;  1E7A A;  1HK5 A;  1E7C A;  1BM0 A;  4ZBR A;  1E7F A;  3UIV A;  2BX8 A;  5GHK A;  3TDL A;  1LOT A;  1E7I A;  4F5T A;  3A73 A;  1HK2 A;  2XVW A;  4LB2 A;  5IJ5 A;  1J78 A;  4LB9 A;  1E7E A;  5IFO A;  5IIX A;  4OR0 A;  3JRY A;  3LU8 A;  1N5U A;  5DBY A;  1HK1 A;  4L9Q A;  2YDF A;  4LUF A;  4PO0 A;  4HGK A;  2XW1 A;  4ZBQ A;  1E7H A;  2BXB A;  5IIU A;  1HK3 A;  4K71 A;  2BXE A;  2XVQ A;  5IIH A;  1KW2 A;  1E78 A;  4LA0 A;  4N0F D;  2BXQ A;  1H9Z A;  4N0U D;  1BKE A;  1KXP D;  5ID7 A;  5IJE A;  5FUO A;  4F5S A;  2XSI A;  1HA2 A;  2BXK A;  4G04 A;  2BXA A;  1E7B A;  2BXD A;  4IW1 A;  4OT2 A;  3V08 A;  2VUE A;  1E7G A;  2I2Z A;  1HK4 A;  2BXF A;  3V09 A;  1UOR A;  4K2C A;  4J2V A;  5DQF A;  3LU7 A;  4S1Y A;  4F5V A;  2I30 A;  5IJF A;  1O9X A;  2BXH A;  3CX9 A;  3B9M A;  5HOZ A;  2XW0 A;  2BXP A;  3JQZ A;  3B9L A;  4G03 A;  4L9K A;  1GNI A;  2BXM A;  2BXC A;  4BKE A;  1MA9 A;  2BXN A; 
#chains in the Genus database with same CATH topology
 4EMX A;  5GIN A;  1J7E A;  2VDB A;  4IW2 A;  4DHX B;  3M99 C;  2QHB A;  3SQJ A;  1H5W A;  1AO6 A;  4E99 A;  4L8U A;  2VUF A;  4BY9 C;  1FOU A;  3GA9 L;  1VZS A;  2NQO A;  4G01 A;  3LU6 A;  2XVV A;  1GNJ A;  2Z8K A;  4LUH A;  2K0N A;  2BXI A;  4BKE A;  1NT2 B;  2GUT A;  1BJ5 A;  2BXG A;  2LQI A;  2XVU A;  3FNM A;  2KWF A;  3ECP A;  2AGH B;  5B5T A;  2JUH A;  2BXO A;  5BPK A;  4HGM B;  4Z69 A;  5ID9 A;  4JK4 A;  5D7G A;  3BPJ A;  2DBX A;  4N3Z A;  1TF0 A;  3KJL A;  2BXL A;  4MBE C;  3V03 A;  1E7A A;  1HK5 A;  3WHS A;  4F5U A;  3NMU A;  3SIU B;  1MIV A;  1E7C A;  1BM0 A;  4OTT A;  3GQX A;  2NNW A;  4D7X A;  2Z8J A;  4Z9O A;  1E7F A;  3MHS B;  4ZBR A;  2DYO A;  3UIV A;  2BX8 A;  5GHK A;  2LXS A;  3TDL A;  2CKX A;  1LOT A;  1E7I A;  4F5T A;  4GG2 A;  3SIV B;  3FWB C;  3ICX A;  1MUS A;  3A73 A;  1HK2 A;  3VQI A;  4TQ1 A;  2XVW A;  4LB2 A;  5IJ5 A;  1J78 A;  1VFI A;  2QMC A;  4LB9 A;  1E7E A;  5IFO A;  5IIX A;  2V36 A;  4OR0 A;  3JRY A;  3LU8 A;  1N5U A;  3NVK A;  2AJE A;  1HK1 A;  4GDL B;  4W4U B;  5DBY A;  4ZC6 A;  3G9K D;  4L9Q A;  1MIW A;  2YDF A;  4LUF A;  4PO0 A;  2DYM A;  4GDK B;  4HGK A;  2XW1 A;  4ZBQ A;  1E7H A;  3H37 A;  4M70 B;  1MIY A;  4DM0 A;  2LOQ A;  3KIK A;  1JNB A;  2BXB A;  5IIU A;  1HK3 A;  4FJC B;  4FK5 B;  2BXE A;  2XVQ A;  3GQU A;  4K71 A;  3MHH B;  5IIH A;  1KW2 A;  1TXU A;  1E78 A;  4LA0 A;  4N0F D;  2BXQ A;  1H9Z A;  4N0U D;  1BKE A;  1KXP D;  5ID7 A;  2EFH A;  4ZCG A;  5IJE A;  5FUO A;  4F5S A;  2DBW A;  2XSI A;  1HA2 A;  1KDX A;  1SB0 A;  2BXK A;  3A75 A;  4G04 A;  1MUH A;  2BXA A;  4GDX A;  3NVM A;  1E7B A;  2BXD A;  4IW1 A;  4OT2 A;  3V08 A;  2LXT A;  2QM6 A;  3WHR A;  4OTU A;  2VUE A;  1IJG A;  1E7G A;  3NVI A;  2I2Z A;  4I9O A;  3W1S A;  3WHQ A;  1HK4 A;  2BXF A;  2KBZ A;  3V09 A;  1UOR A;  4FIP B;  4NAW B;  4WA6 B;  2DG5 A;  4ZBK A;  3H3A A;  2LQH A;  4K2C A;  5GIP A;  4J2V A;  5DQF A;  3FWC C;  3PLA A;  3LU7 A;  4S1Y A;  2E0X A;  4F5V A;  2OT3 A;  2I30 A;  4ZUX V;  2OZB B;  2EFC A;  2Z8I A;  1LNS A;  5IJF A;  2EFE A;  1O9X A;  2BXH A;  2XMO A;  3CX9 A;  4C31 B;  3B9M A;  2ROH A;  2E0Y A;  5HOZ A;  2XW0 A;  2BXP A;  3JQZ A;  3B9L A;  4G03 A;  4L9K A;  1MM8 A;  4TQ0 A;  5GIO A;  1GNI A;  2EFD A;  2BXM A;  2BXC A;  2DBU A;  1MA9 A;  2BXN A; 
#chains in the Genus database with same CATH homology
 4EMX A;  5GIN A;  1J7E A;  2VDB A;  4IW2 A;  4DHX B;  3M99 C;  2QHB A;  3SQJ A;  1H5W A;  1AO6 A;  4E99 A;  4L8U A;  2VUF A;  4BY9 C;  1FOU A;  3GA9 L;  1VZS A;  2NQO A;  4G01 A;  3LU6 A;  2XVV A;  1GNJ A;  2Z8K A;  4LUH A;  2BXI A;  1NT2 B;  1BJ5 A;  2BXG A;  2XVU A;  3FNM A;  5B5T A;  2JUH A;  2BXO A;  4HGM B;  4Z69 A;  5ID9 A;  4JK4 A;  5D7G A;  4N3Z A;  2DBX A;  3V03 A;  1TF0 A;  3KJL A;  2BXL A;  4MBE C;  3WHS A;  1E7A A;  1HK5 A;  4F5U A;  3NMU A;  3SIU B;  1MIV A;  1E7C A;  1BM0 A;  4OTT A;  3GQX A;  2NNW A;  2Z8J A;  4Z9O A;  1E7F A;  3MHS B;  4ZBR A;  2DYO A;  3UIV A;  2BX8 A;  5GHK A;  3TDL A;  2CKX A;  1LOT A;  1E7I A;  4F5T A;  4GG2 A;  3SIV B;  3FWB C;  3ICX A;  3A73 A;  1HK2 A;  3VQI A;  4TQ1 A;  2XVW A;  4LB2 A;  5IJ5 A;  1J78 A;  1VFI A;  2QMC A;  4LB9 A;  1E7E A;  5IFO A;  5IIX A;  2V36 A;  4OR0 A;  3JRY A;  3LU8 A;  1N5U A;  3NVK A;  2AJE A;  1HK1 A;  4GDL B;  4W4U B;  5DBY A;  4ZC6 A;  3G9K D;  4L9Q A;  1MIW A;  2YDF A;  4LUF A;  4PO0 A;  2DYM A;  4GDK B;  4HGK A;  2XW1 A;  4ZBQ A;  1E7H A;  3H37 A;  4M70 B;  1MIY A;  2LOQ A;  3KIK A;  1JNB A;  2BXB A;  5IIU A;  1HK3 A;  4FJC B;  4FK5 B;  2BXE A;  2XVQ A;  3GQU A;  4K71 A;  3MHH B;  5IIH A;  1KW2 A;  1TXU A;  1E78 A;  4LA0 A;  4N0F D;  2BXQ A;  1H9Z A;  4N0U D;  1BKE A;  1KXP D;  5ID7 A;  2EFH A;  4ZCG A;  5IJE A;  5FUO A;  4F5S A;  2DBW A;  2XSI A;  1HA2 A;  2BXK A;  3A75 A;  4G04 A;  2BXA A;  4GDX A;  3NVM A;  1E7B A;  2BXD A;  4IW1 A;  4OT2 A;  3V08 A;  3WHR A;  2QM6 A;  4BKE A;  4OTU A;  2VUE A;  1IJG A;  1E7G A;  3NVI A;  2I2Z A;  3WHQ A;  3W1S A;  5BPK A;  1HK4 A;  2BXF A;  2KBZ A;  3V09 A;  1UOR A;  4FIP B;  4NAW B;  4WA6 B;  2DG5 A;  4ZBK A;  3H3A A;  4K2C A;  5GIP A;  4J2V A;  5DQF A;  3FWC C;  3PLA A;  3LU7 A;  4S1Y A;  2E0X A;  4F5V A;  2OT3 A;  2I30 A;  4ZUX V;  2OZB B;  2EFC A;  2Z8I A;  1LNS A;  5IJF A;  2EFE A;  1O9X A;  2BXH A;  2XMO A;  3CX9 A;  4C31 B;  3B9M A;  2ROH A;  2E0Y A;  5HOZ A;  2XW0 A;  2BXP A;  3JQZ A;  3B9L A;  4G03 A;  4L9K A;  4TQ0 A;  5GIO A;  1GNI A;  2EFD A;  2BXM A;  2BXC A;  2DBU A;  1MA9 A;  2BXN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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