1KXPD

Crystal structure of human vitamin d-binding protein in complex with skeletal actin
Total Genus 162
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
162
sequence length
457
structure length
438
Chain Sequence
LERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPLKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLAQKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCCQEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSRRTHLPEVFLSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKKKLAERLKAKLPDATPKELAKLVNKRSDFASNCCSINSPPLYCDSEIDAELKNI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of the vitamin D-binding protein and its complex with actin: structural basis of the actin-scavenger system.
pubmed doi rcsb
molecule tags Contractile protein/protein binding
molecule keywords ACTIN,ALPHA SKELETAL MUSCLE
total genus 162
structure length 438
sequence length 457
ec nomenclature
pdb deposition date 2002-02-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
D PF00273 Serum_albumin Serum albumin family
D PF09164 VitD-bind_III Vitamin D binding protein, domain III
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1kxpD02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1kxpD03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1kxpD01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1kxpD04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 1kxpD05
4IW2A 1KW2A 1HK3A 2BXNA 2XVQA 1KXPD 1TF0A 1UORA 4EMXA 4F5VA 2XVWA 2XW0A 4HGMB 2BXHA 4LA0A 4Z69A 1E7GA 3V03A 2VDBA 5ID9A 4N0FD 2XSIA 2BXLA 3B9LA 3TDLA 3LU8A 5IIXA 5IJEA 1E7IA 1GNJA 1BM0A 1N5UA 1E7AA 1E7HA 1GNIA 4PO0A 5DQFA 4F5TA 2BXDA 4F5SA 2YDFA 1H9ZA 2BXMA 2VUFA 5IIHA 5IJFA 2I30A 3LU7A 3SQJA 4E99A 2BXPA 5GHKA 5DBYA 1HK4A 4IW1A 5HOZA 1O9XA 2BXGA 2BXBA 4LB2A 4OT2A 4G04A 2XVUA 1BJ5A 5IFOA 5IJ5A 1E7EA 1HA2A 1HK2A 4LUFA 2VUEA 1E7FA 2BXFA 1E7BA 2BXQA 4ZBRA 4S1YA 4J2VA 4L8UA 1E78A 4LUHA 4LB9A 4ZBQA 1J78A 3A73A 2BXIA 1LOTA 4F5UA 4N0UD 1HK1A 5IIUA 3CX9A 3UIVA 3JRYA 1J7EA 1HK5A 2BXAA 3LU6A 2I2ZA 3JQZA 4K71A 3V09A 1AO6A 2BXOA 3B9MA 4K2CA 2BXKA 3V08A 4L9KA 4BKEA 5FUOA 4HGKA 4OR0A 2BX8A 2BXCA 1MA9A 2XVVA 2BXEA 1E7CA 1BKEA 4JK4A 2XW1A 4G03A 4L9QA 5ID7A
chains in the Genus database with same CATH superfamily
4FIPB 1FOUA 3H3AA 4IW2A 2DYMA 1KW2A 1MM8A 2AGHB 1HK3A 3NVKA 2DBUA 2BXNA 2XVQA 5GINA 1SB0A 1KXPD 1TF0A 1UORA 2EFDA 4EMXA 2OT3A 4F5VA 2XVWA 2XW0A 2CKXA 4HGMB 4ZBKA 2BXHA 4LA0A 4D7XA 4Z69A 2QMCA 2NQOA 1MIWA 1E7GA 2V36A 2Z8IA 3V03A 2VDBA 3GQUA 5ID9A 4BY9C 4N0FD 1MUHA 2XSIA 1LNSA 2BXLA 3WHSA 1JNBA 3MHSB 3B9LA 3TDLA 3LU8A 5IIXA 5IJEA 3BPJA 3ECPA 2QM6A 1E7IA 1GNJA 3VQIA 5B5TA 1BM0A 1N5UA 4M70B 1E7AA 1E7HA 1GNIA 3H37A 4PO0A 2QHBA 4OTUA 1IJGA 5DQFA 4F5TA 3NVIA 2BXDA 4F5SA 4NAWB 2K0NA 2YDFA 1H9ZA 2BXMA 2VUFA 2EFCA 2LQHA 5IIHA 5IJFA 4FK5B 4GG2A 4WA6B 2I30A 3FWBC 3SIUB 3LU7A 3SQJA 4E99A 3FWCC 2BXPA 5GHKA 1MUSA 5DBYA 1HK4A 2DBWA 4IW1A 2Z8JA 4ZC6A 5HOZA 2DG5A 3W1SA 2AJEA 4GDXA 1O9XA 2BXGA 1MIVA 2BXBA 4N3ZA 2KBZA 3M99C 4LB2A 2LQIA 4OT2A 4GDKB 5GIOA 4G04A 2XVUA 1BJ5A 5IFOA 5D7GA 4W4UB 2LXSA 5IJ5A 2JUHA 1E7EA 1HA2A 1HK2A 4LUFA 2VUEA 1MIYA 3WHQA 4DM0A 1E7FA 2BXFA 3MHHB 2E0YA 1E7BA 2BXQA 4DHXB 5BPKA 4ZBRA 3KJLA 4S1YA 4J2VA 4L8UA 1H5WA 1E78A 4LUHA 5GIPA 1TXUA 4LB9A 4G01A 2DYOA 2E0XA 3GA9L 4ZBQA 2EFHA 1J78A 3A73A 4FJCB 4MBEC 2BXIA 2LOQA 1LOTA 4OTTA 4F5UA 4Z9OA 4N0UD 3WHRA 1HK1A 3NMUA 4ZCGA 5IIUA 3CX9A 3ICXA 1VFIA 3UIVA 1KDXA 2EFEA 4GDLB 3JRYA 1J7EA 1HK5A 2ROHA 2Z8KA 4I9OA 3PLAA 2BXAA 3LU6A 2KWFA 2LXTA 2I2ZA 3JQZA 4K71A 3A75A 3KIKA 3GQXA 3V09A 1AO6A 2BXOA 4C31B 2OZBB 3B9MA 1NT2B 4K2CA 2BXKA 3V08A 3FNMA 4L9KA 4TQ1A 1VZSA 4TQ0A 4BKEA 5FUOA 4HGKA 4OR0A 4ZUXV 2BX8A 2GUTA 2DBXA 2NNWA 2BXCA 3NVMA 1MA9A 2XVVA 2BXEA 1E7CA 1BKEA 4JK4A 3SIVB 2XMOA 2XW1A 4G03A 4L9QA 3G9KD 5ID7A
chains in the Genus database with same CATH topology
4FIPB 1FOUA 3H3AA 4IW2A 2DYMA 1KW2A 3NVKA 1HK3A 2DBUA 2BXNA 2XVQA 5GINA 1KXPD 1TF0A 1UORA 2EFDA 4EMXA 2OT3A 4F5VA 2XVWA 2XW0A 2CKXA 4HGMB 4ZBKA 2BXHA 4LA0A 4Z69A 2QMCA 2NQOA 1MIWA 1E7GA 2V36A 2Z8IA 3V03A 2VDBA 3GQUA 5ID9A 4BY9C 4N0FD 2XSIA 1LNSA 2BXLA 3WHSA 1JNBA 3MHSB 3B9LA 3TDLA 3LU8A 5IIXA 5IJEA 2QM6A 1E7IA 1GNJA 3VQIA 5B5TA 1BM0A 1N5UA 4M70B 1E7AA 1E7HA 1GNIA 3H37A 4PO0A 2QHBA 4OTUA 1IJGA 5DQFA 4F5TA 3NVIA 2BXDA 4F5SA 4NAWB 2YDFA 1H9ZA 2BXMA 2VUFA 2EFCA 5IIHA 5IJFA 4FK5B 4GG2A 4WA6B 2I30A 3FWBC 3SIUB 3LU7A 3SQJA 4E99A 3FWCC 2BXPA 5GHKA 5DBYA 1HK4A 2DBWA 4IW1A 2Z8JA 4ZC6A 5HOZA 2DG5A 3W1SA 2AJEA 4GDXA 1O9XA 2BXGA 1MIVA 2BXBA 4N3ZA 2KBZA 3M99C 4LB2A 4OT2A 4GDKB 5GIOA 4G04A 2XVUA 1BJ5A 5IFOA 5D7GA 4W4UB 5IJ5A 2JUHA 1E7EA 1HA2A 1HK2A 4LUFA 2VUEA 1MIYA 3WHQA 1E7FA 2BXFA 3MHHB 2E0YA 1E7BA 2BXQA 4DHXB 5BPKA 4ZBRA 3KJLA 4S1YA 4J2VA 4L8UA 1H5WA 1E78A 4LUHA 5GIPA 1TXUA 4LB9A 4G01A 2DYOA 2E0XA 3GA9L 4ZBQA 2EFHA 1J78A 3A73A 4FJCB 4MBEC 2BXIA 2LOQA 1LOTA 4OTTA 4F5UA 4Z9OA 4N0UD 3WHRA 1HK1A 3NMUA 4ZCGA 5IIUA 3CX9A 3ICXA 1VFIA 3UIVA 2EFEA 4GDLB 3JRYA 1J7EA 1HK5A 2ROHA 2Z8KA 3PLAA 2BXAA 3LU6A 2I2ZA 3JQZA 4K71A 3A75A 3KIKA 3GQXA 3V09A 1AO6A 2BXOA 4C31B 2OZBB 3B9MA 1NT2B 4K2CA 2BXKA 3V08A 3FNMA 4L9KA 4TQ1A 1VZSA 4TQ0A 4BKEA 5FUOA 4HGKA 4OR0A 4ZUXV 2BX8A 2DBXA 2NNWA 2BXCA 3NVMA 1MA9A 2XVVA 2BXEA 1E7CA 1BKEA 4JK4A 3SIVB 2XMOA 2XW1A 4G03A 4L9QA 3G9KD 5ID7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IW2 A;  1KW2 A;  1HK3 A;  2BXN A;  2XVQ A;  1KXP D;  1TF0 A;  1UOR A;  4EMX A;  4F5V A;  2XVW A;  2XW0 A;  4HGM B;  2BXH A;  4LA0 A;  4Z69 A;  1E7G A;  3V03 A;  2VDB A;  5ID9 A;  4N0F D;  2XSI A;  2BXL A;  3B9L A;  3TDL A;  3LU8 A;  5IIX A;  5IJE A;  1E7I A;  1GNJ A;  1BM0 A;  1N5U A;  1E7A A;  1E7H A;  1GNI A;  4PO0 A;  5DQF A;  4F5T A;  2BXD A;  4F5S A;  2YDF A;  1H9Z A;  2BXM A;  2VUF A;  5IIH A;  5IJF A;  2I30 A;  3LU7 A;  3SQJ A;  4E99 A;  2BXP A;  5GHK A;  5DBY A;  1HK4 A;  4IW1 A;  5HOZ A;  1O9X A;  2BXG A;  2BXB A;  4LB2 A;  4OT2 A;  4G04 A;  2XVU A;  1BJ5 A;  5IFO A;  5IJ5 A;  1E7E A;  1HA2 A;  1HK2 A;  4LUF A;  2VUE A;  1E7F A;  2BXF A;  1E7B A;  2BXQ A;  4ZBR A;  4S1Y A;  4J2V A;  4L8U A;  1E78 A;  4LUH A;  4LB9 A;  4ZBQ A;  1J78 A;  3A73 A;  2BXI A;  1LOT A;  4F5U A;  4N0U D;  1HK1 A;  5IIU A;  3CX9 A;  3UIV A;  3JRY A;  1J7E A;  1HK5 A;  2BXA A;  3LU6 A;  2I2Z A;  3JQZ A;  4K71 A;  3V09 A;  1AO6 A;  2BXO A;  3B9M A;  4K2C A;  2BXK A;  3V08 A;  4L9K A;  4BKE A;  5FUO A;  4HGK A;  4OR0 A;  2BX8 A;  2BXC A;  1MA9 A;  2XVV A;  2BXE A;  1E7C A;  1BKE A;  4JK4 A;  2XW1 A;  4G03 A;  4L9Q A;  5ID7 A; 
#chains in the Genus database with same CATH topology
 4FIP B;  1FOU A;  3H3A A;  4IW2 A;  2DYM A;  1KW2 A;  1MM8 A;  2AGH B;  1HK3 A;  3NVK A;  2DBU A;  2BXN A;  2XVQ A;  5GIN A;  1SB0 A;  1KXP D;  1TF0 A;  1UOR A;  2EFD A;  4EMX A;  2OT3 A;  4F5V A;  2XVW A;  2XW0 A;  2CKX A;  4HGM B;  4ZBK A;  2BXH A;  4LA0 A;  4D7X A;  4Z69 A;  2QMC A;  2NQO A;  1MIW A;  1E7G A;  2V36 A;  2Z8I A;  3V03 A;  2VDB A;  3GQU A;  5ID9 A;  4BY9 C;  4N0F D;  1MUH A;  2XSI A;  1LNS A;  2BXL A;  3WHS A;  1JNB A;  3MHS B;  3B9L A;  3TDL A;  3LU8 A;  5IIX A;  5IJE A;  3BPJ A;  3ECP A;  2QM6 A;  1E7I A;  1GNJ A;  3VQI A;  5B5T A;  1BM0 A;  1N5U A;  4M70 B;  1E7A A;  1E7H A;  1GNI A;  3H37 A;  4PO0 A;  2QHB A;  4OTU A;  1IJG A;  5DQF A;  4F5T A;  3NVI A;  2BXD A;  4F5S A;  4NAW B;  2K0N A;  2YDF A;  1H9Z A;  2BXM A;  2VUF A;  2EFC A;  2LQH A;  5IIH A;  5IJF A;  4FK5 B;  4GG2 A;  4WA6 B;  2I30 A;  3FWB C;  3SIU B;  3LU7 A;  3SQJ A;  4E99 A;  3FWC C;  2BXP A;  5GHK A;  1MUS A;  5DBY A;  1HK4 A;  2DBW A;  4IW1 A;  2Z8J A;  4ZC6 A;  5HOZ A;  2DG5 A;  3W1S A;  2AJE A;  4GDX A;  1O9X A;  2BXG A;  1MIV A;  2BXB A;  4N3Z A;  2KBZ A;  3M99 C;  4LB2 A;  2LQI A;  4OT2 A;  4GDK B;  5GIO A;  4G04 A;  2XVU A;  1BJ5 A;  5IFO A;  5D7G A;  4W4U B;  2LXS A;  5IJ5 A;  2JUH A;  1E7E A;  1HA2 A;  1HK2 A;  4LUF A;  2VUE A;  1MIY A;  3WHQ A;  4DM0 A;  1E7F A;  2BXF A;  3MHH B;  2E0Y A;  1E7B A;  2BXQ A;  4DHX B;  5BPK A;  4ZBR A;  3KJL A;  4S1Y A;  4J2V A;  4L8U A;  1H5W A;  1E78 A;  4LUH A;  5GIP A;  1TXU A;  4LB9 A;  4G01 A;  2DYO A;  2E0X A;  3GA9 L;  4ZBQ A;  2EFH A;  1J78 A;  3A73 A;  4FJC B;  4MBE C;  2BXI A;  2LOQ A;  1LOT A;  4OTT A;  4F5U A;  4Z9O A;  4N0U D;  3WHR A;  1HK1 A;  3NMU A;  4ZCG A;  5IIU A;  3CX9 A;  3ICX A;  1VFI A;  3UIV A;  1KDX A;  2EFE A;  4GDL B;  3JRY A;  1J7E A;  1HK5 A;  2ROH A;  2Z8K A;  4I9O A;  3PLA A;  2BXA A;  3LU6 A;  2KWF A;  2LXT A;  2I2Z A;  3JQZ A;  4K71 A;  3A75 A;  3KIK A;  3GQX A;  3V09 A;  1AO6 A;  2BXO A;  4C31 B;  2OZB B;  3B9M A;  1NT2 B;  4K2C A;  2BXK A;  3V08 A;  3FNM A;  4L9K A;  4TQ1 A;  1VZS A;  4TQ0 A;  4BKE A;  5FUO A;  4HGK A;  4OR0 A;  4ZUX V;  2BX8 A;  2GUT A;  2DBX A;  2NNW A;  2BXC A;  3NVM A;  1MA9 A;  2XVV A;  2BXE A;  1E7C A;  1BKE A;  4JK4 A;  3SIV B;  2XMO A;  2XW1 A;  4G03 A;  4L9Q A;  3G9K D;  5ID7 A; 
#chains in the Genus database with same CATH homology
 4FIP B;  1FOU A;  3H3A A;  4IW2 A;  2DYM A;  1KW2 A;  3NVK A;  1HK3 A;  2DBU A;  2BXN A;  2XVQ A;  5GIN A;  1KXP D;  1TF0 A;  1UOR A;  2EFD A;  4EMX A;  2OT3 A;  4F5V A;  2XVW A;  2XW0 A;  2CKX A;  4HGM B;  4ZBK A;  2BXH A;  4LA0 A;  4Z69 A;  2QMC A;  2NQO A;  1MIW A;  1E7G A;  2V36 A;  2Z8I A;  3V03 A;  2VDB A;  3GQU A;  5ID9 A;  4BY9 C;  4N0F D;  2XSI A;  1LNS A;  2BXL A;  3WHS A;  1JNB A;  3MHS B;  3B9L A;  3TDL A;  3LU8 A;  5IIX A;  5IJE A;  2QM6 A;  1E7I A;  1GNJ A;  3VQI A;  5B5T A;  1BM0 A;  1N5U A;  4M70 B;  1E7A A;  1E7H A;  1GNI A;  3H37 A;  4PO0 A;  2QHB A;  4OTU A;  1IJG A;  5DQF A;  4F5T A;  3NVI A;  2BXD A;  4F5S A;  4NAW B;  2YDF A;  1H9Z A;  2BXM A;  2VUF A;  2EFC A;  5IIH A;  5IJF A;  4FK5 B;  4GG2 A;  4WA6 B;  2I30 A;  3FWB C;  3SIU B;  3LU7 A;  3SQJ A;  4E99 A;  3FWC C;  2BXP A;  5GHK A;  5DBY A;  1HK4 A;  2DBW A;  4IW1 A;  2Z8J A;  4ZC6 A;  5HOZ A;  2DG5 A;  3W1S A;  2AJE A;  4GDX A;  1O9X A;  2BXG A;  1MIV A;  2BXB A;  4N3Z A;  2KBZ A;  3M99 C;  4LB2 A;  4OT2 A;  4GDK B;  5GIO A;  4G04 A;  2XVU A;  1BJ5 A;  5IFO A;  5D7G A;  4W4U B;  5IJ5 A;  2JUH A;  1E7E A;  1HA2 A;  1HK2 A;  4LUF A;  2VUE A;  1MIY A;  3WHQ A;  1E7F A;  2BXF A;  3MHH B;  2E0Y A;  1E7B A;  2BXQ A;  4DHX B;  5BPK A;  4ZBR A;  3KJL A;  4S1Y A;  4J2V A;  4L8U A;  1H5W A;  1E78 A;  4LUH A;  5GIP A;  1TXU A;  4LB9 A;  4G01 A;  2DYO A;  2E0X A;  3GA9 L;  4ZBQ A;  2EFH A;  1J78 A;  3A73 A;  4FJC B;  4MBE C;  2BXI A;  2LOQ A;  1LOT A;  4OTT A;  4F5U A;  4Z9O A;  4N0U D;  3WHR A;  1HK1 A;  3NMU A;  4ZCG A;  5IIU A;  3CX9 A;  3ICX A;  1VFI A;  3UIV A;  2EFE A;  4GDL B;  3JRY A;  1J7E A;  1HK5 A;  2ROH A;  2Z8K A;  3PLA A;  2BXA A;  3LU6 A;  2I2Z A;  3JQZ A;  4K71 A;  3A75 A;  3KIK A;  3GQX A;  3V09 A;  1AO6 A;  2BXO A;  4C31 B;  2OZB B;  3B9M A;  1NT2 B;  4K2C A;  2BXK A;  3V08 A;  3FNM A;  4L9K A;  4TQ1 A;  1VZS A;  4TQ0 A;  4BKE A;  5FUO A;  4HGK A;  4OR0 A;  4ZUX V;  2BX8 A;  2DBX A;  2NNW A;  2BXC A;  3NVM A;  1MA9 A;  2XVV A;  2BXE A;  1E7C A;  1BKE A;  4JK4 A;  3SIV B;  2XMO A;  2XW1 A;  4G03 A;  4L9Q A;  3G9K D;  5ID7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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