2BXDA

Human serum albumin complexed with warfarin
Total Genus 214
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
214
sequence length
578
structure length
578
Chain Sequence
SEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis of the Drug-Binding Specificity of Human Serum Albumin.
pubmed doi rcsb
molecule tags Transport protein
source organism Homo sapiens
molecule keywords SERUM ALBUMIN
total genus 214
structure length 578
sequence length 578
chains with identical sequence B
ec nomenclature
pdb deposition date 2005-07-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 2bxdA03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 2bxdA02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 2bxdA04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 2bxdA01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 2bxdA06
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 2bxdA05
2XSIA 1E7FA 3V03A 4F5SA 2BXEA 2VDBA 4LUFA 4EMXA 4K2CA 2BXHA 5IJEA 2BXKA 1GNJA 1E7EA 4G03A 1E7AA 1HK2A 1J78A 5IFOA 2VUEA 3UIVA 5ID7A 2BXPA 4LB9A 2BXQA 5IIHA 1O9XA 5DQFA 3LU7A 1HK1A 4ZBRA 1J7EA 4L9KA 4LUHA 1MA9A 2BXMA 2BXAA 4OR0A 4L9QA 3B9MA 3CX9A 4IW2A 1E7GA 4J2VA 2I30A 2BXLA 3V09A 1E7HA 2BXNA 1KXPD 1E7BA 1H9ZA 2BXFA 1LOTA 2BXOA 1BKEA 3B9LA 4S1YA 1AO6A 4F5VA 2XVQA 5IJFA 2I2ZA 2VUFA 5HOZA 2YDFA 2XW0A 5DBYA 4PO0A 5IIUA 3JRYA 3JQZA 1KW2A 1BM0A 4F5TA 4JK4A 2BXCA 1E7CA 1HK5A 1HK3A 1N5UA 4Z69A 2XVVA 2XVUA 4N0FD 5GHKA 4IW1A 4K71A 3TDLA 2BXBA 2BXIA 1TF0A 1GNIA 2XW1A 1BJ5A 2BXGA 4BKEA 1UORA 3SQJA 5ID9A 5IJ5A 4E99A 1HA2A 1HK4A 4N0UD 4LA0A 1E78A 4ZBQA 2BX8A 4LB2A 4OT2A 3LU8A 4L8UA 5IIXA 1E7IA 4G04A 2XVWA 5FUOA 3A73A 3V08A 4HGKA 4F5UA 2BXDA 4HGMB 3LU6A
chains in the Genus database with same CATH superfamily
2EFHA 4DM0A 2XSIA 1E7FA 2JUHA 3V03A 1H5WA 2AJEA 2V36A 4F5SA 2OZBB 2DBWA 2DBUA 1MUSA 2BXEA 2VDBA 4LUFA 3NMUA 4EMXA 4K2CA 2LQHA 2BXHA 4TQ1A 5IJEA 2BXKA 1GNJA 4Z9OA 1E7EA 4G03A 1E7AA 5B5TA 1HK2A 2OT3A 1J78A 3FWCC 5IFOA 4C31B 5BPKA 5GINA 2E0YA 2VUEA 2DG5A 4BY9C 3UIVA 5ID7A 2BXPA 2LXTA 4OTTA 3NVKA 4LB9A 3ECPA 3H37A 2BXQA 4GG2A 2GUTA 5IIHA 1O9XA 2XMOA 3SIUB 5DQFA 1HK1A 3LU7A 2EFEA 4ZBRA 3G9KD 1J7EA 2ROHA 4L9KA 4LUHA 4FK5B 1MA9A 2KBZA 5D7GA 2BXMA 1MIYA 3W1SA 2BXAA 3M99C 4OR0A 2QHBA 4L9QA 4MBEC 2NNWA 3B9MA 3CX9A 1VZSA 4IW2A 1E7GA 2NQOA 4J2VA 1KDXA 2I30A 3GQUA 3FWBC 3KIKA 4GDKB 3SIVB 2BXLA 3V09A 1E7HA 4I9OA 2BXNA 4GDXA 1KXPD 2LQIA 1E7BA 1H9ZA 3VQIA 2DBXA 3ICXA 2BXFA 1LOTA 2BXOA 3BPJA 1BKEA 2DYOA 3B9LA 4S1YA 1AO6A 3NVIA 2QM6A 4ZUXV 4F5VA 2XVQA 5IJFA 2I2ZA 2VUFA 4D7XA 2Z8IA 2K0NA 3KJLA 4M70B 5HOZA 3MHSB 2YDFA 2XW0A 4FJCB 5DBYA 4PO0A 3NVMA 5IIUA 2LXSA 2KWFA 3JRYA 4FIPB 4GDLB 3JQZA 3A75A 3PLAA 4DHXB 3H3AA 1KW2A 3GA9L 3LU6A 1BM0A 4F5TA 4JK4A 2BXCA 4ZCGA 5GIOA 1E7CA 1HK5A 1HK3A 1N5UA 4Z69A 2Z8KA 2CKXA 3WHRA 4TQ0A 2XVVA 3WHQA 2XVUA 4N0FD 5GHKA 3WHSA 4G01A 4IW1A 3MHHB 2DYMA 4K71A 3TDLA 1LNSA 2BXIA 1TF0A 1GNIA 2XW1A 1MIVA 1BJ5A 2BXGA 1MM8A 2LOQA 1SB0A 4BKEA 1UORA 3SQJA 5ID9A 5IJ5A 4E99A 4OTUA 1HA2A 1HK4A 4N0UD 1NT2B 4LA0A 1E78A 4ZBKA 1IJGA 1VFIA 4ZBQA 2BX8A 4LB2A 4OT2A 3LU8A 1MIWA 2E0XA 4L8UA 5GIPA 4N3ZA 1MUHA 5IIXA 1TXUA 2AGHB 4NAWB 1E7IA 4WA6B 3GQXA 4ZC6A 1FOUA 3FNMA 4G04A 2XVWA 5FUOA 4W4UB 3A73A 2QMCA 1JNBA 3V08A 2EFCA 4HGKA 4F5UA 2EFDA 2Z8JA 2BXDA 4HGMB 2BXBA
chains in the Genus database with same CATH topology
2EFHA 2XSIA 1E7FA 2JUHA 3V03A 1H5WA 2AJEA 2V36A 4F5SA 2OZBB 2DBWA 2DBUA 2BXEA 2VDBA 4LUFA 3NMUA 4EMXA 4K2CA 2BXHA 4TQ1A 5IJEA 2BXKA 1GNJA 4Z9OA 1E7EA 4G03A 1E7AA 5B5TA 1HK2A 2OT3A 1J78A 3FWCC 5IFOA 4C31B 5BPKA 5GINA 2E0YA 2VUEA 2DG5A 4BY9C 3UIVA 5ID7A 2BXPA 4OTTA 3NVKA 4LB9A 3H37A 2BXQA 4GG2A 5IIHA 1O9XA 2XMOA 3SIUB 5DQFA 1HK1A 3LU7A 2EFEA 4ZBRA 3G9KD 1J7EA 2ROHA 4L9KA 4LUHA 4FK5B 1MA9A 2KBZA 5D7GA 2BXMA 1MIYA 3W1SA 2BXAA 3M99C 4OR0A 2QHBA 4L9QA 4MBEC 2NNWA 3B9MA 3CX9A 1VZSA 4IW2A 1E7GA 2NQOA 4J2VA 2I30A 3GQUA 3FWBC 3KIKA 4GDKB 3SIVB 2BXLA 3V09A 1E7HA 2BXNA 4GDXA 1KXPD 1E7BA 1H9ZA 3VQIA 2DBXA 3ICXA 2BXFA 1LOTA 2BXOA 1BKEA 2DYOA 3B9LA 4S1YA 1AO6A 3NVIA 2QM6A 4ZUXV 4F5VA 2XVQA 5IJFA 2I2ZA 2VUFA 2Z8IA 3KJLA 4M70B 5HOZA 3MHSB 2YDFA 2XW0A 4FJCB 5DBYA 4PO0A 3NVMA 5IIUA 3JRYA 4FIPB 4GDLB 3JQZA 3A75A 3PLAA 4DHXB 3H3AA 1KW2A 3GA9L 3LU6A 1BM0A 4F5TA 4JK4A 2BXCA 4ZCGA 5GIOA 1E7CA 1HK5A 1HK3A 1N5UA 4Z69A 2Z8KA 2CKXA 3WHRA 4TQ0A 2XVVA 3WHQA 2XVUA 4N0FD 5GHKA 3WHSA 4G01A 4IW1A 3MHHB 2DYMA 4K71A 3TDLA 1LNSA 2BXIA 1TF0A 1GNIA 2XW1A 1MIVA 1BJ5A 2BXGA 2LOQA 4BKEA 1UORA 3SQJA 5ID9A 5IJ5A 4E99A 4OTUA 1HA2A 1HK4A 4N0UD 1NT2B 4LA0A 1E78A 4ZBKA 1IJGA 1VFIA 4ZBQA 2BX8A 4LB2A 4OT2A 3LU8A 1MIWA 2E0XA 4L8UA 5GIPA 4N3ZA 5IIXA 1TXUA 4NAWB 1E7IA 4WA6B 3GQXA 4ZC6A 1FOUA 3FNMA 4G04A 2XVWA 5FUOA 4W4UB 3A73A 2QMCA 1JNBA 3V08A 2EFCA 4HGKA 4F5UA 2EFDA 2Z8JA 2BXDA 4HGMB 2BXBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XSI A;  1E7F A;  3V03 A;  4F5S A;  2BXE A;  2VDB A;  4LUF A;  4EMX A;  4K2C A;  2BXH A;  5IJE A;  2BXK A;  1GNJ A;  1E7E A;  4G03 A;  1E7A A;  1HK2 A;  1J78 A;  5IFO A;  2VUE A;  3UIV A;  5ID7 A;  2BXP A;  4LB9 A;  2BXQ A;  5IIH A;  1O9X A;  5DQF A;  3LU7 A;  1HK1 A;  4ZBR A;  1J7E A;  4L9K A;  4LUH A;  1MA9 A;  2BXM A;  2BXA A;  4OR0 A;  4L9Q A;  3B9M A;  3CX9 A;  4IW2 A;  1E7G A;  4J2V A;  2I30 A;  2BXL A;  3V09 A;  1E7H A;  2BXN A;  1KXP D;  1E7B A;  1H9Z A;  2BXF A;  1LOT A;  2BXO A;  1BKE A;  3B9L A;  4S1Y A;  1AO6 A;  4F5V A;  2XVQ A;  5IJF A;  2I2Z A;  2VUF A;  5HOZ A;  2YDF A;  2XW0 A;  5DBY A;  4PO0 A;  5IIU A;  3JRY A;  3JQZ A;  1KW2 A;  1BM0 A;  4F5T A;  4JK4 A;  2BXC A;  1E7C A;  1HK5 A;  1HK3 A;  1N5U A;  4Z69 A;  2XVV A;  2XVU A;  4N0F D;  5GHK A;  4IW1 A;  4K71 A;  3TDL A;  2BXB A;  2BXI A;  1TF0 A;  1GNI A;  2XW1 A;  1BJ5 A;  2BXG A;  4BKE A;  1UOR A;  3SQJ A;  5ID9 A;  5IJ5 A;  4E99 A;  1HA2 A;  1HK4 A;  4N0U D;  4LA0 A;  1E78 A;  4ZBQ A;  2BX8 A;  4LB2 A;  4OT2 A;  3LU8 A;  4L8U A;  5IIX A;  1E7I A;  4G04 A;  2XVW A;  5FUO A;  3A73 A;  3V08 A;  4HGK A;  4F5U A;  2BXD A;  4HGM B;  3LU6 A; 
#chains in the Genus database with same CATH topology
 2EFH A;  4DM0 A;  2XSI A;  1E7F A;  2JUH A;  3V03 A;  1H5W A;  2AJE A;  2V36 A;  4F5S A;  2OZB B;  2DBW A;  2DBU A;  1MUS A;  2BXE A;  2VDB A;  4LUF A;  3NMU A;  4EMX A;  4K2C A;  2LQH A;  2BXH A;  4TQ1 A;  5IJE A;  2BXK A;  1GNJ A;  4Z9O A;  1E7E A;  4G03 A;  1E7A A;  5B5T A;  1HK2 A;  2OT3 A;  1J78 A;  3FWC C;  5IFO A;  4C31 B;  5BPK A;  5GIN A;  2E0Y A;  2VUE A;  2DG5 A;  4BY9 C;  3UIV A;  5ID7 A;  2BXP A;  2LXT A;  4OTT A;  3NVK A;  4LB9 A;  3ECP A;  3H37 A;  2BXQ A;  4GG2 A;  2GUT A;  5IIH A;  1O9X A;  2XMO A;  3SIU B;  5DQF A;  1HK1 A;  3LU7 A;  2EFE A;  4ZBR A;  3G9K D;  1J7E A;  2ROH A;  4L9K A;  4LUH A;  4FK5 B;  1MA9 A;  2KBZ A;  5D7G A;  2BXM A;  1MIY A;  3W1S A;  2BXA A;  3M99 C;  4OR0 A;  2QHB A;  4L9Q A;  4MBE C;  2NNW A;  3B9M A;  3CX9 A;  1VZS A;  4IW2 A;  1E7G A;  2NQO A;  4J2V A;  1KDX A;  2I30 A;  3GQU A;  3FWB C;  3KIK A;  4GDK B;  3SIV B;  2BXL A;  3V09 A;  1E7H A;  4I9O A;  2BXN A;  4GDX A;  1KXP D;  2LQI A;  1E7B A;  1H9Z A;  3VQI A;  2DBX A;  3ICX A;  2BXF A;  1LOT A;  2BXO A;  3BPJ A;  1BKE A;  2DYO A;  3B9L A;  4S1Y A;  1AO6 A;  3NVI A;  2QM6 A;  4ZUX V;  4F5V A;  2XVQ A;  5IJF A;  2I2Z A;  2VUF A;  4D7X A;  2Z8I A;  2K0N A;  3KJL A;  4M70 B;  5HOZ A;  3MHS B;  2YDF A;  2XW0 A;  4FJC B;  5DBY A;  4PO0 A;  3NVM A;  5IIU A;  2LXS A;  2KWF A;  3JRY A;  4FIP B;  4GDL B;  3JQZ A;  3A75 A;  3PLA A;  4DHX B;  3H3A A;  1KW2 A;  3GA9 L;  3LU6 A;  1BM0 A;  4F5T A;  4JK4 A;  2BXC A;  4ZCG A;  5GIO A;  1E7C A;  1HK5 A;  1HK3 A;  1N5U A;  4Z69 A;  2Z8K A;  2CKX A;  3WHR A;  4TQ0 A;  2XVV A;  3WHQ A;  2XVU A;  4N0F D;  5GHK A;  3WHS A;  4G01 A;  4IW1 A;  3MHH B;  2DYM A;  4K71 A;  3TDL A;  1LNS A;  2BXI A;  1TF0 A;  1GNI A;  2XW1 A;  1MIV A;  1BJ5 A;  2BXG A;  1MM8 A;  2LOQ A;  1SB0 A;  4BKE A;  1UOR A;  3SQJ A;  5ID9 A;  5IJ5 A;  4E99 A;  4OTU A;  1HA2 A;  1HK4 A;  4N0U D;  1NT2 B;  4LA0 A;  1E78 A;  4ZBK A;  1IJG A;  1VFI A;  4ZBQ A;  2BX8 A;  4LB2 A;  4OT2 A;  3LU8 A;  1MIW A;  2E0X A;  4L8U A;  5GIP A;  4N3Z A;  1MUH A;  5IIX A;  1TXU A;  2AGH B;  4NAW B;  1E7I A;  4WA6 B;  3GQX A;  4ZC6 A;  1FOU A;  3FNM A;  4G04 A;  2XVW A;  5FUO A;  4W4U B;  3A73 A;  2QMC A;  1JNB A;  3V08 A;  2EFC A;  4HGK A;  4F5U A;  2EFD A;  2Z8J A;  2BXD A;  4HGM B;  2BXB A; 
#chains in the Genus database with same CATH homology
 2EFH A;  2XSI A;  1E7F A;  2JUH A;  3V03 A;  1H5W A;  2AJE A;  2V36 A;  4F5S A;  2OZB B;  2DBW A;  2DBU A;  2BXE A;  2VDB A;  4LUF A;  3NMU A;  4EMX A;  4K2C A;  2BXH A;  4TQ1 A;  5IJE A;  2BXK A;  1GNJ A;  4Z9O A;  1E7E A;  4G03 A;  1E7A A;  5B5T A;  1HK2 A;  2OT3 A;  1J78 A;  3FWC C;  5IFO A;  4C31 B;  5BPK A;  5GIN A;  2E0Y A;  2VUE A;  2DG5 A;  4BY9 C;  3UIV A;  5ID7 A;  2BXP A;  4OTT A;  3NVK A;  4LB9 A;  3H37 A;  2BXQ A;  4GG2 A;  5IIH A;  1O9X A;  2XMO A;  3SIU B;  5DQF A;  1HK1 A;  3LU7 A;  2EFE A;  4ZBR A;  3G9K D;  1J7E A;  2ROH A;  4L9K A;  4LUH A;  4FK5 B;  1MA9 A;  2KBZ A;  5D7G A;  2BXM A;  1MIY A;  3W1S A;  2BXA A;  3M99 C;  4OR0 A;  2QHB A;  4L9Q A;  4MBE C;  2NNW A;  3B9M A;  3CX9 A;  1VZS A;  4IW2 A;  1E7G A;  2NQO A;  4J2V A;  2I30 A;  3GQU A;  3FWB C;  3KIK A;  4GDK B;  3SIV B;  2BXL A;  3V09 A;  1E7H A;  2BXN A;  4GDX A;  1KXP D;  1E7B A;  1H9Z A;  3VQI A;  2DBX A;  3ICX A;  2BXF A;  1LOT A;  2BXO A;  1BKE A;  2DYO A;  3B9L A;  4S1Y A;  1AO6 A;  3NVI A;  2QM6 A;  4ZUX V;  4F5V A;  2XVQ A;  5IJF A;  2I2Z A;  2VUF A;  2Z8I A;  3KJL A;  4M70 B;  5HOZ A;  3MHS B;  2YDF A;  2XW0 A;  4FJC B;  5DBY A;  4PO0 A;  3NVM A;  5IIU A;  3JRY A;  4FIP B;  4GDL B;  3JQZ A;  3A75 A;  3PLA A;  4DHX B;  3H3A A;  1KW2 A;  3GA9 L;  3LU6 A;  1BM0 A;  4F5T A;  4JK4 A;  2BXC A;  4ZCG A;  5GIO A;  1E7C A;  1HK5 A;  1HK3 A;  1N5U A;  4Z69 A;  2Z8K A;  2CKX A;  3WHR A;  4TQ0 A;  2XVV A;  3WHQ A;  2XVU A;  4N0F D;  5GHK A;  3WHS A;  4G01 A;  4IW1 A;  3MHH B;  2DYM A;  4K71 A;  3TDL A;  1LNS A;  2BXI A;  1TF0 A;  1GNI A;  2XW1 A;  1MIV A;  1BJ5 A;  2BXG A;  2LOQ A;  4BKE A;  1UOR A;  3SQJ A;  5ID9 A;  5IJ5 A;  4E99 A;  4OTU A;  1HA2 A;  1HK4 A;  4N0U D;  1NT2 B;  4LA0 A;  1E78 A;  4ZBK A;  1IJG A;  1VFI A;  4ZBQ A;  2BX8 A;  4LB2 A;  4OT2 A;  3LU8 A;  1MIW A;  2E0X A;  4L8U A;  5GIP A;  4N3Z A;  5IIX A;  1TXU A;  4NAW B;  1E7I A;  4WA6 B;  3GQX A;  4ZC6 A;  1FOU A;  3FNM A;  4G04 A;  2XVW A;  5FUO A;  4W4U B;  3A73 A;  2QMC A;  1JNB A;  3V08 A;  2EFC A;  4HGK A;  4F5U A;  2EFD A;  2Z8J A;  2BXD A;  4HGM B;  2BXB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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