2KWFA

The structure of e-protein activation domain 1 bound to the kix domain of cbp/p300 elucidates leukemia induction by e2a-pbx1
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
87
structure length
87
Chain Sequence
GVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structure of E-protein activation domain 1 bound to the KIX domain of CBP/p300 elucidates leukemia induction by E2A-PBX1
rcsb
molecule tags Transcription
source organism Homo sapiens
molecule keywords CREB-binding protein
total genus 25
structure length 87
sequence length 87
ec nomenclature ec 2.3.1.48: Histone acetyltransferase.
pdb deposition date 2010-04-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02172 KIX KIX domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.20 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Coactivator CBP, KIX domain 2kwfA00
2KWFA 1SB0A 4I9OA 2LXSA 1KDXA 2K0NA 2GUTA 2AGHB 4D7XA 2LQHA 2LXTA 2LQIA
chains in the Genus database with same CATH superfamily
2DBXA 2DYMA 4W4UB 2VUEA 3GQXA 5GHKA 4LA0A 4L8UA 5IIUA 4N0FD 2VUFA 4OR0A 5GIPA 4DHXB 3LU6A 1N5UA 3V03A 1AO6A 3GA9L 5IJ5A 4GDXA 3SQJA 1TXUA 1E7BA 2QM6A 2LXSA 1KDXA 2K0NA 4TQ1A 1H9ZA 3B9LA 2NNWA 2XW0A 4LUHA 2YDFA 1FOUA 3ICXA 4F5SA 2DG5A 4F5TA 3SIUB 1J78A 1E7IA 1MA9A 5B5TA 1BM0A 1LNSA 2EFHA 4NAWB 2AJEA 4L9KA 3B9MA 5HOZA 2CKXA 5GIOA 3LU8A 4G03A 3FNMA 5IIXA 4BKEA 4E99A 4N0UD 4ZCGA 4ZUXV 2QMCA 2BXAA 2Z8KA 2BXQA 2GUTA 1E7EA 4D7XA 3KJLA 5BPKA 2BXKA 1KW2A 5DBYA 1H5WA 4MBEC 2BXGA 2V36A 4LB2A 1J7EA 5IIHA 1MUHA 3LU7A 3PLAA 3MHSB 1BJ5A 2I2ZA 2XMOA 3A73A 3JQZA 4JK4A 4S1YA 1E7GA 2BXOA 3A75A 5GINA 2DBWA 2XVUA 1TF0A 1MIWA 4J2VA 2JUHA 4EMXA 2DYOA 1E7HA 4HGMB 4Z69A 4K2CA 2QHBA 4GDLB 1NT2B 4L9QA 3NVIA 4F5VA 4FIPB 4M70B 4K71A 4ZC6A 4LUFA 2NQOA 2LOQA 1VFIA 1HK1A 2BXFA 2KWFA 4GDKB 4C31B 2BXCA 1JNBA 3CX9A 2I30A 3V09A 1MUSA 3M99C 4PO0A 2EFEA 3ECPA 2LXTA 2BXDA 2XW1A 2LQIA 4OTUA 2XSIA 4IW2A 3MHHB 4F5UA 5ID9A 3NMUA 4HGKA 4N3ZA 3G9KD 1E7AA 2VDBA 4I9OA 3KIKA 4TQ0A 1E7FA 3TDLA 4DM0A 3H3AA 5D7GA 4WA6B 5ID7A 1GNJA 3VQIA 2BXBA 5IJEA 1SB0A 3NVMA 1IJGA 1MIYA 2AGHB 1E7CA 1O9XA 2BXIA 4OTTA 3WHQA 1KXPD 4FK5B 3H37A 3GQUA 5FUOA 4Z9OA 1HK4A 5IFOA 4ZBKA 3UIVA 2BXNA 2Z8IA 4G04A 4ZBQA 3WHRA 3V08A 2BXLA 3FWCC 2BXHA 3WHSA 5DQFA 4G01A 2XVVA 2EFCA 5IJFA 3FWBC 4IW1A 2ROHA 4LB9A 3SIVB 1VZSA 1HK3A 4GG2A 4FJCB 2BX8A 2EFDA 1HA2A 1GNIA 1E78A 4OT2A 3NVKA 2DBUA 1BKEA 4ZBRA 2BXMA 2E0YA 2XVQA 4BY9C 1HK2A 1UORA 2E0XA 2KBZA 2XVWA 1HK5A 1MIVA 2OT3A 2Z8JA 3W1SA 3BPJA 1MM8A 1LOTA 2BXEA 2BXPA 3JRYA 2LQHA 2OZBB
chains in the Genus database with same CATH topology
2KWFA 1SB0A 4I9OA 2LXSA 1KDXA 2K0NA 2GUTA 2AGHB 4D7XA 2LQHA 2LXTA 2LQIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2KWF A;  1SB0 A;  4I9O A;  2LXS A;  1KDX A;  2K0N A;  2GUT A;  2AGH B;  4D7X A;  2LQH A;  2LXT A;  2LQI A; 
#chains in the Genus database with same CATH topology
 2DBX A;  2DYM A;  4W4U B;  2VUE A;  3GQX A;  5GHK A;  4LA0 A;  4L8U A;  5IIU A;  4N0F D;  2VUF A;  4OR0 A;  5GIP A;  4DHX B;  3LU6 A;  1N5U A;  3V03 A;  1AO6 A;  3GA9 L;  5IJ5 A;  4GDX A;  3SQJ A;  1TXU A;  1E7B A;  2QM6 A;  2LXS A;  1KDX A;  2K0N A;  4TQ1 A;  1H9Z A;  3B9L A;  2NNW A;  2XW0 A;  4LUH A;  2YDF A;  1FOU A;  3ICX A;  4F5S A;  2DG5 A;  4F5T A;  3SIU B;  1J78 A;  1E7I A;  1MA9 A;  5B5T A;  1BM0 A;  1LNS A;  2EFH A;  4NAW B;  2AJE A;  4L9K A;  3B9M A;  5HOZ A;  2CKX A;  5GIO A;  3LU8 A;  4G03 A;  3FNM A;  5IIX A;  4BKE A;  4E99 A;  4N0U D;  4ZCG A;  4ZUX V;  2QMC A;  2BXA A;  2Z8K A;  2BXQ A;  2GUT A;  1E7E A;  4D7X A;  3KJL A;  5BPK A;  2BXK A;  1KW2 A;  5DBY A;  1H5W A;  4MBE C;  2BXG A;  2V36 A;  4LB2 A;  1J7E A;  5IIH A;  1MUH A;  3LU7 A;  3PLA A;  3MHS B;  1BJ5 A;  2I2Z A;  2XMO A;  3A73 A;  3JQZ A;  4JK4 A;  4S1Y A;  1E7G A;  2BXO A;  3A75 A;  5GIN A;  2DBW A;  2XVU A;  1TF0 A;  1MIW A;  4J2V A;  2JUH A;  4EMX A;  2DYO A;  1E7H A;  4HGM B;  4Z69 A;  4K2C A;  2QHB A;  4GDL B;  1NT2 B;  4L9Q A;  3NVI A;  4F5V A;  4FIP B;  4M70 B;  4K71 A;  4ZC6 A;  4LUF A;  2NQO A;  2LOQ A;  1VFI A;  1HK1 A;  2BXF A;  2KWF A;  4GDK B;  4C31 B;  2BXC A;  1JNB A;  3CX9 A;  2I30 A;  3V09 A;  1MUS A;  3M99 C;  4PO0 A;  2EFE A;  3ECP A;  2LXT A;  2BXD A;  2XW1 A;  2LQI A;  4OTU A;  2XSI A;  4IW2 A;  3MHH B;  4F5U A;  5ID9 A;  3NMU A;  4HGK A;  4N3Z A;  3G9K D;  1E7A A;  2VDB A;  4I9O A;  3KIK A;  4TQ0 A;  1E7F A;  3TDL A;  4DM0 A;  3H3A A;  5D7G A;  4WA6 B;  5ID7 A;  1GNJ A;  3VQI A;  2BXB A;  5IJE A;  1SB0 A;  3NVM A;  1IJG A;  1MIY A;  2AGH B;  1E7C A;  1O9X A;  2BXI A;  4OTT A;  3WHQ A;  1KXP D;  4FK5 B;  3H37 A;  3GQU A;  5FUO A;  4Z9O A;  1HK4 A;  5IFO A;  4ZBK A;  3UIV A;  2BXN A;  2Z8I A;  4G04 A;  4ZBQ A;  3WHR A;  3V08 A;  2BXL A;  3FWC C;  2BXH A;  3WHS A;  5DQF A;  4G01 A;  2XVV A;  2EFC A;  5IJF A;  3FWB C;  4IW1 A;  2ROH A;  4LB9 A;  3SIV B;  1VZS A;  1HK3 A;  4GG2 A;  4FJC B;  2BX8 A;  2EFD A;  1HA2 A;  1GNI A;  1E78 A;  4OT2 A;  3NVK A;  2DBU A;  1BKE A;  4ZBR A;  2BXM A;  2E0Y A;  2XVQ A;  4BY9 C;  1HK2 A;  1UOR A;  2E0X A;  2KBZ A;  2XVW A;  1HK5 A;  1MIV A;  2OT3 A;  2Z8J A;  3W1S A;  3BPJ A;  1MM8 A;  1LOT A;  2BXE A;  2BXP A;  3JRY A;  2LQH A;  2OZB B; 
#chains in the Genus database with same CATH homology
 2KWF A;  1SB0 A;  4I9O A;  2LXS A;  1KDX A;  2K0N A;  2GUT A;  2AGH B;  4D7X A;  2LQH A;  2LXT A;  2LQI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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