2LXTA

Allosteric communication in the kix domain proceeds through dynamic re-packing of the hydrophobic core
Total Genus 29
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
29
sequence length
87
structure length
87
Chain Sequence
GVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Allosteric Communication in the KIX Domain Proceeds through Dynamic Repacking of the Hydrophobic Core.
pubmed doi rcsb
molecule tags Transferase/protein binding
source organism Homo sapiens
molecule keywords CREB-binding protein
total genus 29
structure length 87
sequence length 87
ec nomenclature ec 2.3.1.48: Histone acetyltransferase.
pdb deposition date 2012-08-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02172 KIX KIX domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.20 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Coactivator CBP, KIX domain 2lxtA00
4I9OA 1SB0A 2GUTA 2LQHA 2LXSA 1KDXA 2LXTA 2KWFA 2AGHB 2LQIA 2K0NA 4D7XA
chains in the Genus database with same CATH superfamily
4WA6B 3BPJA 3V03A 4G03A 2XVUA 3MHHB 4K2CA 4N0FD 5GHKA 2EFCA 3CX9A 4LUFA 4ZC6A 1GNJA 1H5WA 3H3AA 4OTUA 3A73A 2LXTA 5IJEA 2BXAA 2BXIA 1KXPD 4FK5B 4BKEA 2ROHA 1HK1A 2BXHA 2OZBB 4IW2A 5IIHA 3WHRA 4F5SA 1E7IA 1MIWA 5B5TA 4W4UB 3NVMA 4F5UA 4ZBQA 4LA0A 4HGMB 3PLAA 4NAWB 5IFOA 1KW2A 1MUHA 1IJGA 2EFHA 1TXUA 1TF0A 1LNSA 2BXKA 3FWCC 4MBEC 2DYOA 2BXLA 2K0NA 2BXNA 2XW0A 2BXFA 3G9KD 3JRYA 4K71A 3V09A 4DHXB 4F5TA 5ID9A 1E7AA 1HK5A 2LQHA 2LXSA 2OT3A 1BKEA 3A75A 4JK4A 2QM6A 4L8UA 4OR0A 1UORA 1O9XA 2BXQA 4GDKB 1AO6A 4HGKA 4G01A 2DYMA 3FNMA 3JQZA 1H9ZA 4L9KA 1LOTA 3ECPA 1GNIA 3NVIA 1MA9A 2NNWA 1NT2B 2Z8IA 5IIXA 2DBWA 4GG2A 5DBYA 1MUSA 3WHQA 2E0XA 5GIPA 1J7EA 2XVWA 2BXGA 2XVQA 4OT2A 3B9MA 2EFEA 3LU6A 5GIOA 1SB0A 3NVKA 2DG5A 2XVVA 3KIKA 4ZBRA 2BX8A 1J78A 2LQIA 2Z8JA 1E7GA 4ZBKA 2YDFA 3M99C 4LB9A 4ZCGA 4GDLB 3SQJA 4F5VA 4ZUXV 4BY9C 2BXOA 2V36A 3TDLA 3KJLA 4C31B 2XW1A 5IJ5A 2BXCA 3WHSA 5IJFA 1MIVA 2KBZA 3GQXA 2CKXA 4LB2A 4G04A 4J2VA 4LUHA 2BXEA 4FIPB 4TQ0A 4PO0A 5BPKA 2DBXA 2I30A 5ID7A 3SIVB 4TQ1A 1FOUA 5IIUA 3SIUB 4M70B 2AGHB 2VUEA 2VUFA 4N0UD 4FJCB 5DQFA 5FUOA 1HK4A 2NQOA 1E7CA 4S1YA 3MHSB 1VZSA 3ICXA 2LOQA 1E7HA 3H37A 4D7XA 3V08A 2QHBA 2XMOA 2GUTA 3GA9L 5HOZA 1E7EA 1MM8A 3LU7A 2JUHA 2Z8KA 1KDXA 4EMXA 5GINA 4I9OA 1BM0A 1E7FA 1JNBA 3B9LA 2BXBA 2VDBA 5D7GA 4L9QA 4Z9OA 4OTTA 3UIVA 1E7BA 4GDXA 1N5UA 2AJEA 4Z69A 1HK3A 2QMCA 3W1SA 3LU8A 2EFDA 2I2ZA 4E99A 4DM0A 2DBUA 2E0YA 1HA2A 2KWFA 2XSIA 4IW1A 2BXPA 4N3ZA 1VFIA 1E78A 3GQUA 1BJ5A 2BXMA 3FWBC 1MIYA 3NMUA 1HK2A 3VQIA 2BXDA
chains in the Genus database with same CATH topology
4I9OA 1SB0A 2GUTA 2LQHA 2LXSA 1KDXA 2LXTA 2KWFA 2AGHB 2LQIA 2K0NA 4D7XA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4I9O A;  1SB0 A;  2GUT A;  2LQH A;  2LXS A;  1KDX A;  2LXT A;  2KWF A;  2AGH B;  2LQI A;  2K0N A;  4D7X A; 
#chains in the Genus database with same CATH topology
 4WA6 B;  3BPJ A;  3V03 A;  4G03 A;  2XVU A;  3MHH B;  4K2C A;  4N0F D;  5GHK A;  2EFC A;  3CX9 A;  4LUF A;  4ZC6 A;  1GNJ A;  1H5W A;  3H3A A;  4OTU A;  3A73 A;  2LXT A;  5IJE A;  2BXA A;  2BXI A;  1KXP D;  4FK5 B;  4BKE A;  2ROH A;  1HK1 A;  2BXH A;  2OZB B;  4IW2 A;  5IIH A;  3WHR A;  4F5S A;  1E7I A;  1MIW A;  5B5T A;  4W4U B;  3NVM A;  4F5U A;  4ZBQ A;  4LA0 A;  4HGM B;  3PLA A;  4NAW B;  5IFO A;  1KW2 A;  1MUH A;  1IJG A;  2EFH A;  1TXU A;  1TF0 A;  1LNS A;  2BXK A;  3FWC C;  4MBE C;  2DYO A;  2BXL A;  2K0N A;  2BXN A;  2XW0 A;  2BXF A;  3G9K D;  3JRY A;  4K71 A;  3V09 A;  4DHX B;  4F5T A;  5ID9 A;  1E7A A;  1HK5 A;  2LQH A;  2LXS A;  2OT3 A;  1BKE A;  3A75 A;  4JK4 A;  2QM6 A;  4L8U A;  4OR0 A;  1UOR A;  1O9X A;  2BXQ A;  4GDK B;  1AO6 A;  4HGK A;  4G01 A;  2DYM A;  3FNM A;  3JQZ A;  1H9Z A;  4L9K A;  1LOT A;  3ECP A;  1GNI A;  3NVI A;  1MA9 A;  2NNW A;  1NT2 B;  2Z8I A;  5IIX A;  2DBW A;  4GG2 A;  5DBY A;  1MUS A;  3WHQ A;  2E0X A;  5GIP A;  1J7E A;  2XVW A;  2BXG A;  2XVQ A;  4OT2 A;  3B9M A;  2EFE A;  3LU6 A;  5GIO A;  1SB0 A;  3NVK A;  2DG5 A;  2XVV A;  3KIK A;  4ZBR A;  2BX8 A;  1J78 A;  2LQI A;  2Z8J A;  1E7G A;  4ZBK A;  2YDF A;  3M99 C;  4LB9 A;  4ZCG A;  4GDL B;  3SQJ A;  4F5V A;  4ZUX V;  4BY9 C;  2BXO A;  2V36 A;  3TDL A;  3KJL A;  4C31 B;  2XW1 A;  5IJ5 A;  2BXC A;  3WHS A;  5IJF A;  1MIV A;  2KBZ A;  3GQX A;  2CKX A;  4LB2 A;  4G04 A;  4J2V A;  4LUH A;  2BXE A;  4FIP B;  4TQ0 A;  4PO0 A;  5BPK A;  2DBX A;  2I30 A;  5ID7 A;  3SIV B;  4TQ1 A;  1FOU A;  5IIU A;  3SIU B;  4M70 B;  2AGH B;  2VUE A;  2VUF A;  4N0U D;  4FJC B;  5DQF A;  5FUO A;  1HK4 A;  2NQO A;  1E7C A;  4S1Y A;  3MHS B;  1VZS A;  3ICX A;  2LOQ A;  1E7H A;  3H37 A;  4D7X A;  3V08 A;  2QHB A;  2XMO A;  2GUT A;  3GA9 L;  5HOZ A;  1E7E A;  1MM8 A;  3LU7 A;  2JUH A;  2Z8K A;  1KDX A;  4EMX A;  5GIN A;  4I9O A;  1BM0 A;  1E7F A;  1JNB A;  3B9L A;  2BXB A;  2VDB A;  5D7G A;  4L9Q A;  4Z9O A;  4OTT A;  3UIV A;  1E7B A;  4GDX A;  1N5U A;  2AJE A;  4Z69 A;  1HK3 A;  2QMC A;  3W1S A;  3LU8 A;  2EFD A;  2I2Z A;  4E99 A;  4DM0 A;  2DBU A;  2E0Y A;  1HA2 A;  2KWF A;  2XSI A;  4IW1 A;  2BXP A;  4N3Z A;  1VFI A;  1E78 A;  3GQU A;  1BJ5 A;  2BXM A;  3FWB C;  1MIY A;  3NMU A;  1HK2 A;  3VQI A;  2BXD A; 
#chains in the Genus database with same CATH homology
 4I9O A;  1SB0 A;  2GUT A;  2LQH A;  2LXS A;  1KDX A;  2LXT A;  2KWF A;  2AGH B;  2LQI A;  2K0N A;  4D7X A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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