2LXTA

Allosteric communication in the kix domain proceeds through dynamic re-packing of the hydrophobic core
Total Genus 29
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
29
sequence length
87
structure length
87
Chain Sequence
GVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Allosteric Communication in the KIX Domain Proceeds through Dynamic Repacking of the Hydrophobic Core.
pubmed doi rcsb
molecule tags Transferase/protein binding
source organism Homo sapiens
molecule keywords CREB-binding protein
total genus 29
structure length 87
sequence length 87
ec nomenclature ec 2.3.1.48: Histone acetyltransferase.
pdb deposition date 2012-08-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02172 KIX KIX domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.20 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Coactivator CBP, KIX domain 2lxtA00
2GUTA 1KDXA 2AGHB 1SB0A 4I9OA 4D7XA 2LXTA 2K0NA 2KWFA 2LXSA 2LQIA 2LQHA
chains in the Genus database with same CATH superfamily
2GUTA 4DM0A 3V09A 3LU6A 4N0UD 2OZBB 3MHSB 3SQJA 1MA9A 1BJ5A 4Z9OA 4EMXA 1HK2A 4C31B 3GQUA 4FJCB 2DYMA 3A75A 4M70B 2QM6A 1N5UA 3ECPA 2BXQA 2XVWA 1KW2A 2BXHA 4FIPB 2BX8A 4L9KA 3ICXA 2BXLA 1E78A 3GA9L 5IIHA 1MIVA 4BY9C 3PLAA 2VUEA 2BXFA 2LXTA 2XW0A 2KWFA 3CX9A 3A73A 4FK5B 5IJFA 4OTTA 2EFDA 2EFCA 2LQHA 4LA0A 3WHSA 1TXUA 2NQOA 1E7CA 4OTUA 1JNBA 3BPJA 3FWBC 4ZC6A 2AJEA 1E7FA 2KBZA 4LUFA 2VUFA 1VZSA 2DBWA 1E7HA 2VDBA 2YDFA 3B9LA 3MHHB 4PO0A 1LNSA 5GHKA 3B9MA 5FUOA 3VQIA 2BXOA 2BXAA 4ZUXV 4N3ZA 3NMUA 4N0FD 2EFHA 2ROHA 5GIPA 2E0YA 2LOQA 4K2CA 1KXPD 4IW2A 5D7GA 1HA2A 1TF0A 1J7EA 4DHXB 3KJLA 4ZBQA 4ZBKA 3UIVA 3NVIA 2BXGA 3WHRA 4LB9A 4GDXA 4TQ0A 1HK1A 2I30A 3KIKA 2BXNA 2XVUA 4I9OA 4IW1A 1MUSA 3TDLA 5B5TA 5BPKA 2LXSA 3JQZA 2BXPA 3GQXA 4F5TA 4OT2A 3M99C 4WA6B 2DBUA 4W4UB 2I2ZA 1MIWA 4G01A 2XVVA 3WHQA 2BXDA 4L8UA 1HK5A 1KDXA 1SB0A 4BKEA 2QHBA 2CKXA 1IJGA 4NAWB 1E7GA 5IJ5A 1E7BA 2AGHB 5DBYA 4K71A 2DG5A 3H3AA 1J78A 2BXIA 5IJEA 3NVKA 1BM0A 2Z8JA 4E99A 2OT3A 4J2VA 5GINA 3SIVB 4JK4A 5HOZA 3V03A 4GG2A 2Z8IA 3G9KD 4HGMB 5IIUA 1O9XA 4TQ1A 2Z8KA 1LOTA 3JRYA 1AO6A 2LQIA 1BKEA 1UORA 2BXEA 5ID9A 1FOUA 2JUHA 1MUHA 4L9QA 4GDLB 5IFOA 4G04A 4F5VA 4G03A 2XSIA 4LUHA 1HK4A 2XVQA 5IIXA 2NNWA 1VFIA 3NVMA 3V08A 5ID7A 1HK3A 1H5WA 5DQFA 4OR0A 1H9ZA 2BXBA 2EFEA 2K0NA 1GNIA 4Z69A 5GIOA 1GNJA 2XW1A 4ZCGA 3H37A 4S1YA 4MBEC 4ZBRA 2QMCA 4F5SA 4F5UA 2XMOA 2V36A 3LU8A 2BXCA 2DYOA 4GDKB 3FNMA 3W1SA 3SIUB 1NT2B 2BXMA 1MIYA 4LB2A 4D7XA 1E7EA 1E7IA 4HGKA 1E7AA 2BXKA 2E0XA 3LU7A 2DBXA 1MM8A 3FWCC
chains in the Genus database with same CATH topology
2GUTA 1KDXA 2AGHB 1SB0A 4I9OA 4D7XA 2LXTA 2K0NA 2KWFA 2LXSA 2LQIA 2LQHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GUT A;  1KDX A;  2AGH B;  1SB0 A;  4I9O A;  4D7X A;  2LXT A;  2K0N A;  2KWF A;  2LXS A;  2LQI A;  2LQH A; 
#chains in the Genus database with same CATH topology
 2GUT A;  4DM0 A;  3V09 A;  3LU6 A;  4N0U D;  2OZB B;  3MHS B;  3SQJ A;  1MA9 A;  1BJ5 A;  4Z9O A;  4EMX A;  1HK2 A;  4C31 B;  3GQU A;  4FJC B;  2DYM A;  3A75 A;  4M70 B;  2QM6 A;  1N5U A;  3ECP A;  2BXQ A;  2XVW A;  1KW2 A;  2BXH A;  4FIP B;  2BX8 A;  4L9K A;  3ICX A;  2BXL A;  1E78 A;  3GA9 L;  5IIH A;  1MIV A;  4BY9 C;  3PLA A;  2VUE A;  2BXF A;  2LXT A;  2XW0 A;  2KWF A;  3CX9 A;  3A73 A;  4FK5 B;  5IJF A;  4OTT A;  2EFD A;  2EFC A;  2LQH A;  4LA0 A;  3WHS A;  1TXU A;  2NQO A;  1E7C A;  4OTU A;  1JNB A;  3BPJ A;  3FWB C;  4ZC6 A;  2AJE A;  1E7F A;  2KBZ A;  4LUF A;  2VUF A;  1VZS A;  2DBW A;  1E7H A;  2VDB A;  2YDF A;  3B9L A;  3MHH B;  4PO0 A;  1LNS A;  5GHK A;  3B9M A;  5FUO A;  3VQI A;  2BXO A;  2BXA A;  4ZUX V;  4N3Z A;  3NMU A;  4N0F D;  2EFH A;  2ROH A;  5GIP A;  2E0Y A;  2LOQ A;  4K2C A;  1KXP D;  4IW2 A;  5D7G A;  1HA2 A;  1TF0 A;  1J7E A;  4DHX B;  3KJL A;  4ZBQ A;  4ZBK A;  3UIV A;  3NVI A;  2BXG A;  3WHR A;  4LB9 A;  4GDX A;  4TQ0 A;  1HK1 A;  2I30 A;  3KIK A;  2BXN A;  2XVU A;  4I9O A;  4IW1 A;  1MUS A;  3TDL A;  5B5T A;  5BPK A;  2LXS A;  3JQZ A;  2BXP A;  3GQX A;  4F5T A;  4OT2 A;  3M99 C;  4WA6 B;  2DBU A;  4W4U B;  2I2Z A;  1MIW A;  4G01 A;  2XVV A;  3WHQ A;  2BXD A;  4L8U A;  1HK5 A;  1KDX A;  1SB0 A;  4BKE A;  2QHB A;  2CKX A;  1IJG A;  4NAW B;  1E7G A;  5IJ5 A;  1E7B A;  2AGH B;  5DBY A;  4K71 A;  2DG5 A;  3H3A A;  1J78 A;  2BXI A;  5IJE A;  3NVK A;  1BM0 A;  2Z8J A;  4E99 A;  2OT3 A;  4J2V A;  5GIN A;  3SIV B;  4JK4 A;  5HOZ A;  3V03 A;  4GG2 A;  2Z8I A;  3G9K D;  4HGM B;  5IIU A;  1O9X A;  4TQ1 A;  2Z8K A;  1LOT A;  3JRY A;  1AO6 A;  2LQI A;  1BKE A;  1UOR A;  2BXE A;  5ID9 A;  1FOU A;  2JUH A;  1MUH A;  4L9Q A;  4GDL B;  5IFO A;  4G04 A;  4F5V A;  4G03 A;  2XSI A;  4LUH A;  1HK4 A;  2XVQ A;  5IIX A;  2NNW A;  1VFI A;  3NVM A;  3V08 A;  5ID7 A;  1HK3 A;  1H5W A;  5DQF A;  4OR0 A;  1H9Z A;  2BXB A;  2EFE A;  2K0N A;  1GNI A;  4Z69 A;  5GIO A;  1GNJ A;  2XW1 A;  4ZCG A;  3H37 A;  4S1Y A;  4MBE C;  4ZBR A;  2QMC A;  4F5S A;  4F5U A;  2XMO A;  2V36 A;  3LU8 A;  2BXC A;  2DYO A;  4GDK B;  3FNM A;  3W1S A;  3SIU B;  1NT2 B;  2BXM A;  1MIY A;  4LB2 A;  4D7X A;  1E7E A;  1E7I A;  4HGK A;  1E7A A;  2BXK A;  2E0X A;  3LU7 A;  2DBX A;  1MM8 A;  3FWC C; 
#chains in the Genus database with same CATH homology
 2GUT A;  1KDX A;  2AGH B;  1SB0 A;  4I9O A;  4D7X A;  2LXT A;  2K0N A;  2KWF A;  2LXS A;  2LQI A;  2LQH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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