2BXGA

Human serum albumin complexed with ibuprofen
Total Genus 216
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
216
sequence length
578
structure length
578
Chain Sequence
SEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis of the Drug-Binding Specificity of Human Serum Albumin.
pubmed doi rcsb
molecule tags Transport protein
source organism Homo sapiens
molecule keywords SERUM ALBUMIN
total genus 216
structure length 578
sequence length 578
chains with identical sequence B
ec nomenclature
pdb deposition date 2005-07-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 2bxgA03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 2bxgA02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 2bxgA04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 2bxgA01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 2bxgA06
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 2bxgA05
4F5SA 2XW1A 2BXKA 5HOZA 4ZBQA 1HK2A 3SQJA 2XVWA 1HK1A 4LUFA 5ID7A 1HA2A 4LA0A 5DQFA 4LB2A 2BXOA 5IJ5A 3V03A 1E7IA 2VDBA 4F5VA 1N5UA 4S1YA 3LU6A 5IIXA 2VUEA 1E7CA 1LOTA 4L9KA 4J2VA 1HK3A 4ZBRA 1HK5A 4IW2A 4IW1A 4PO0A 1E7GA 4Z69A 2BX8A 1E7BA 2BXIA 2XVVA 2I30A 1O9XA 1J78A 2BXAA 1BJ5A 3B9MA 2BXNA 2BXFA 4N0UD 5IJEA 2BXDA 1KXPD 1AO6A 4L9QA 3B9LA 1E7AA 2VUFA 4L8UA 2BXHA 4F5UA 1BKEA 1MA9A 1GNIA 1E78A 2BXEA 3A73A 1GNJA 2BXCA 3UIVA 3JRYA 4E99A 2BXLA 4F5TA 3CX9A 4BKEA 1E7EA 2BXGA 2XVQA 4LUHA 5IJFA 3LU8A 2BXPA 3V08A 3TDLA 4G04A 4HGKA 1H9ZA 5IIHA 1HK4A 5DBYA 5FUOA 4JK4A 5IIUA 4OT2A 2BXMA 1KW2A 4N0FD 2BXBA 2YDFA 4OR0A 1TF0A 4LB9A 4EMXA 1J7EA 5IFOA 4K71A 1BM0A 2I2ZA 1E7HA 2BXQA 4HGMB 2XVUA 2XW0A 1E7FA 4K2CA 5ID9A 3LU7A 5GHKA 3V09A 1UORA 4G03A 3JQZA 2XSIA
chains in the Genus database with same CATH superfamily
3ICXA 3WHRA 4F5SA 4TQ1A 2LXSA 1JNBA 3SIVB 3W1SA 4OTUA 2XW1A 4W4UB 2BXKA 2KBZA 5HOZA 2OZBB 4DHXB 3GQXA 1HK2A 4ZBQA 2XVWA 1HK1A 2EFDA 3FWBC 3SQJA 4LUFA 5ID7A 2EFHA 1HA2A 3WHSA 4ZCGA 2GUTA 5GIOA 2LOQA 4LA0A 4NAWB 2AGHB 5DQFA 4LB2A 3A75A 1MM8A 2BXOA 1SB0A 5IJ5A 3H3AA 3V03A 3WHQA 3H37A 5BPKA 1E7IA 2VDBA 4BY9C 4F5VA 1N5UA 4S1YA 1MIWA 3LU6A 5IIXA 3PLAA 2VUEA 1E7CA 1LOTA 4FK5B 4L9KA 3KJLA 4J2VA 3NVMA 1HK3A 2KWFA 1HK5A 4ZBRA 3SIUB 4IW2A 4FIPB 5B5TA 2EFEA 4IW1A 4GDLB 3GA9L 1E7GA 4PO0A 4Z69A 2BX8A 1E7BA 2BXIA 2K0NA 2XVVA 1VFIA 2I30A 1O9XA 3KIKA 1H5WA 4TQ0A 2NQOA 1J78A 2BXAA 1BJ5A 3B9MA 2BXNA 2Z8IA 2BXFA 2DYMA 4N0UD 2ROHA 2BXDA 4OTTA 1KXPD 5IJEA 1AO6A 4L9QA 3B9LA 1E7AA 2VUFA 4L8UA 1LNSA 2BXHA 2LQIA 2JUHA 4GG2A 4F5UA 3BPJA 1BKEA 1MA9A 1GNIA 1E78A 2BXEA 4GDXA 3NVIA 5GIPA 3A73A 1GNJA 2BXCA 2DBUA 4MBEC 3UIVA 3JRYA 4E99A 2DG5A 2BXLA 4F5TA 2E0YA 1MIYA 3CX9A 4BKEA 1MUHA 4ZUXV 1MIVA 1E7EA 2LQHA 2BXGA 4C31B 2V36A 2XVQA 1TXUA 3NMUA 4LUHA 2EFCA 3FNMA 3LU8A 5IJFA 3VQIA 4DM0A 2BXPA 3V08A 3TDLA 4G04A 1VZSA 4HGKA 1NT2B 4FJCB 1H9ZA 5IIHA 1HK4A 5DBYA 5FUOA 4JK4A 2NNWA 2DBWA 2LXTA 5IIUA 4I9OA 4WA6B 4OT2A 2BXMA 4ZBKA 1KW2A 3G9KD 3MHSB 2Z8JA 4N0FD 3ECPA 1KDXA 2BXBA 1FOUA 3M99C 4ZC6A 4GDKB 2OT3A 2YDFA 4OR0A 1TF0A 2DBXA 4LB9A 4Z9OA 2E0XA 1J7EA 5IFOA 4EMXA 4K71A 1MUSA 3GQUA 1BM0A 2I2ZA 2XMOA 2QMCA 4N3ZA 4D7XA 4G01A 3NVKA 1E7HA 5D7GA 2DYOA 2Z8KA 2BXQA 4HGMB 2XVUA 2QHBA 2QM6A 2XW0A 5GINA 1E7FA 3MHHB 4K2CA 5ID9A 3LU7A 5GHKA 2AJEA 2CKXA 3V09A 1IJGA 1UORA 3FWCC 4M70B 4G03A 3JQZA 2XSIA
chains in the Genus database with same CATH topology
3ICXA 3WHRA 4F5SA 4TQ1A 1JNBA 3SIVB 3W1SA 4OTUA 2XW1A 4W4UB 2BXKA 2KBZA 5HOZA 2OZBB 4DHXB 3GQXA 1HK2A 4ZBQA 2XVWA 1HK1A 2EFDA 3FWBC 3SQJA 4LUFA 5ID7A 2EFHA 1HA2A 3WHSA 4ZCGA 5GIOA 2LOQA 4LA0A 4NAWB 5DQFA 4LB2A 3A75A 2BXOA 5IJ5A 3H3AA 3V03A 3WHQA 3H37A 5BPKA 1E7IA 2VDBA 4BY9C 4F5VA 1N5UA 4S1YA 1MIWA 3LU6A 5IIXA 3PLAA 2VUEA 1E7CA 1LOTA 4FK5B 4L9KA 3KJLA 4J2VA 3NVMA 1HK3A 4ZBRA 1HK5A 3SIUB 4IW2A 4FIPB 5B5TA 2EFEA 4IW1A 4GDLB 3GA9L 1E7GA 4PO0A 4Z69A 2BX8A 1E7BA 2BXIA 2XVVA 1VFIA 2I30A 1O9XA 3KIKA 1H5WA 4TQ0A 2NQOA 1J78A 2BXAA 1BJ5A 3B9MA 2BXNA 2Z8IA 2BXFA 2DYMA 4N0UD 2ROHA 2BXDA 4OTTA 1KXPD 5IJEA 1AO6A 4L9QA 3B9LA 1E7AA 2VUFA 4L8UA 1LNSA 2BXHA 4GG2A 2JUHA 4F5UA 1BKEA 1MA9A 1GNIA 1E78A 2BXEA 4GDXA 3NVIA 5GIPA 3A73A 1GNJA 2BXCA 2DBUA 4MBEC 3UIVA 3JRYA 4E99A 2DG5A 2BXLA 4F5TA 2E0YA 1MIYA 3CX9A 4BKEA 4ZUXV 1MIVA 1E7EA 2BXGA 4C31B 2V36A 2XVQA 1TXUA 3NMUA 4LUHA 2EFCA 3FNMA 3LU8A 5IJFA 3VQIA 2BXPA 3V08A 3TDLA 4G04A 1VZSA 4HGKA 1NT2B 4FJCB 1H9ZA 5IIHA 1HK4A 5DBYA 5FUOA 4JK4A 2NNWA 2DBWA 5IIUA 4WA6B 4OT2A 2BXMA 4ZBKA 1KW2A 3G9KD 3MHSB 2Z8JA 4N0FD 2BXBA 1FOUA 3M99C 4ZC6A 4GDKB 2OT3A 2YDFA 4OR0A 1TF0A 2DBXA 4LB9A 4Z9OA 2E0XA 1J7EA 5IFOA 4EMXA 4K71A 3GQUA 1BM0A 2I2ZA 2XMOA 2QMCA 4N3ZA 3NVKA 4G01A 1E7HA 5D7GA 2DYOA 2Z8KA 2BXQA 4HGMB 2XVUA 2QHBA 2QM6A 2XW0A 5GINA 1E7FA 3MHHB 4K2CA 5ID9A 3LU7A 5GHKA 2AJEA 2CKXA 3V09A 1IJGA 1UORA 3FWCC 4M70B 4G03A 3JQZA 2XSIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4F5S A;  2XW1 A;  2BXK A;  5HOZ A;  4ZBQ A;  1HK2 A;  3SQJ A;  2XVW A;  1HK1 A;  4LUF A;  5ID7 A;  1HA2 A;  4LA0 A;  5DQF A;  4LB2 A;  2BXO A;  5IJ5 A;  3V03 A;  1E7I A;  2VDB A;  4F5V A;  1N5U A;  4S1Y A;  3LU6 A;  5IIX A;  2VUE A;  1E7C A;  1LOT A;  4L9K A;  4J2V A;  1HK3 A;  4ZBR A;  1HK5 A;  4IW2 A;  4IW1 A;  4PO0 A;  1E7G A;  4Z69 A;  2BX8 A;  1E7B A;  2BXI A;  2XVV A;  2I30 A;  1O9X A;  1J78 A;  2BXA A;  1BJ5 A;  3B9M A;  2BXN A;  2BXF A;  4N0U D;  5IJE A;  2BXD A;  1KXP D;  1AO6 A;  4L9Q A;  3B9L A;  1E7A A;  2VUF A;  4L8U A;  2BXH A;  4F5U A;  1BKE A;  1MA9 A;  1GNI A;  1E78 A;  2BXE A;  3A73 A;  1GNJ A;  2BXC A;  3UIV A;  3JRY A;  4E99 A;  2BXL A;  4F5T A;  3CX9 A;  4BKE A;  1E7E A;  2BXG A;  2XVQ A;  4LUH A;  5IJF A;  3LU8 A;  2BXP A;  3V08 A;  3TDL A;  4G04 A;  4HGK A;  1H9Z A;  5IIH A;  1HK4 A;  5DBY A;  5FUO A;  4JK4 A;  5IIU A;  4OT2 A;  2BXM A;  1KW2 A;  4N0F D;  2BXB A;  2YDF A;  4OR0 A;  1TF0 A;  4LB9 A;  4EMX A;  1J7E A;  5IFO A;  4K71 A;  1BM0 A;  2I2Z A;  1E7H A;  2BXQ A;  4HGM B;  2XVU A;  2XW0 A;  1E7F A;  4K2C A;  5ID9 A;  3LU7 A;  5GHK A;  3V09 A;  1UOR A;  4G03 A;  3JQZ A;  2XSI A; 
#chains in the Genus database with same CATH topology
 3ICX A;  3WHR A;  4F5S A;  4TQ1 A;  2LXS A;  1JNB A;  3SIV B;  3W1S A;  4OTU A;  2XW1 A;  4W4U B;  2BXK A;  2KBZ A;  5HOZ A;  2OZB B;  4DHX B;  3GQX A;  1HK2 A;  4ZBQ A;  2XVW A;  1HK1 A;  2EFD A;  3FWB C;  3SQJ A;  4LUF A;  5ID7 A;  2EFH A;  1HA2 A;  3WHS A;  4ZCG A;  2GUT A;  5GIO A;  2LOQ A;  4LA0 A;  4NAW B;  2AGH B;  5DQF A;  4LB2 A;  3A75 A;  1MM8 A;  2BXO A;  1SB0 A;  5IJ5 A;  3H3A A;  3V03 A;  3WHQ A;  3H37 A;  5BPK A;  1E7I A;  2VDB A;  4BY9 C;  4F5V A;  1N5U A;  4S1Y A;  1MIW A;  3LU6 A;  5IIX A;  3PLA A;  2VUE A;  1E7C A;  1LOT A;  4FK5 B;  4L9K A;  3KJL A;  4J2V A;  3NVM A;  1HK3 A;  2KWF A;  1HK5 A;  4ZBR A;  3SIU B;  4IW2 A;  4FIP B;  5B5T A;  2EFE A;  4IW1 A;  4GDL B;  3GA9 L;  1E7G A;  4PO0 A;  4Z69 A;  2BX8 A;  1E7B A;  2BXI A;  2K0N A;  2XVV A;  1VFI A;  2I30 A;  1O9X A;  3KIK A;  1H5W A;  4TQ0 A;  2NQO A;  1J78 A;  2BXA A;  1BJ5 A;  3B9M A;  2BXN A;  2Z8I A;  2BXF A;  2DYM A;  4N0U D;  2ROH A;  2BXD A;  4OTT A;  1KXP D;  5IJE A;  1AO6 A;  4L9Q A;  3B9L A;  1E7A A;  2VUF A;  4L8U A;  1LNS A;  2BXH A;  2LQI A;  2JUH A;  4GG2 A;  4F5U A;  3BPJ A;  1BKE A;  1MA9 A;  1GNI A;  1E78 A;  2BXE A;  4GDX A;  3NVI A;  5GIP A;  3A73 A;  1GNJ A;  2BXC A;  2DBU A;  4MBE C;  3UIV A;  3JRY A;  4E99 A;  2DG5 A;  2BXL A;  4F5T A;  2E0Y A;  1MIY A;  3CX9 A;  4BKE A;  1MUH A;  4ZUX V;  1MIV A;  1E7E A;  2LQH A;  2BXG A;  4C31 B;  2V36 A;  2XVQ A;  1TXU A;  3NMU A;  4LUH A;  2EFC A;  3FNM A;  3LU8 A;  5IJF A;  3VQI A;  4DM0 A;  2BXP A;  3V08 A;  3TDL A;  4G04 A;  1VZS A;  4HGK A;  1NT2 B;  4FJC B;  1H9Z A;  5IIH A;  1HK4 A;  5DBY A;  5FUO A;  4JK4 A;  2NNW A;  2DBW A;  2LXT A;  5IIU A;  4I9O A;  4WA6 B;  4OT2 A;  2BXM A;  4ZBK A;  1KW2 A;  3G9K D;  3MHS B;  2Z8J A;  4N0F D;  3ECP A;  1KDX A;  2BXB A;  1FOU A;  3M99 C;  4ZC6 A;  4GDK B;  2OT3 A;  2YDF A;  4OR0 A;  1TF0 A;  2DBX A;  4LB9 A;  4Z9O A;  2E0X A;  1J7E A;  5IFO A;  4EMX A;  4K71 A;  1MUS A;  3GQU A;  1BM0 A;  2I2Z A;  2XMO A;  2QMC A;  4N3Z A;  4D7X A;  4G01 A;  3NVK A;  1E7H A;  5D7G A;  2DYO A;  2Z8K A;  2BXQ A;  4HGM B;  2XVU A;  2QHB A;  2QM6 A;  2XW0 A;  5GIN A;  1E7F A;  3MHH B;  4K2C A;  5ID9 A;  3LU7 A;  5GHK A;  2AJE A;  2CKX A;  3V09 A;  1IJG A;  1UOR A;  3FWC C;  4M70 B;  4G03 A;  3JQZ A;  2XSI A; 
#chains in the Genus database with same CATH homology
 3ICX A;  3WHR A;  4F5S A;  4TQ1 A;  1JNB A;  3SIV B;  3W1S A;  4OTU A;  2XW1 A;  4W4U B;  2BXK A;  2KBZ A;  5HOZ A;  2OZB B;  4DHX B;  3GQX A;  1HK2 A;  4ZBQ A;  2XVW A;  1HK1 A;  2EFD A;  3FWB C;  3SQJ A;  4LUF A;  5ID7 A;  2EFH A;  1HA2 A;  3WHS A;  4ZCG A;  5GIO A;  2LOQ A;  4LA0 A;  4NAW B;  5DQF A;  4LB2 A;  3A75 A;  2BXO A;  5IJ5 A;  3H3A A;  3V03 A;  3WHQ A;  3H37 A;  5BPK A;  1E7I A;  2VDB A;  4BY9 C;  4F5V A;  1N5U A;  4S1Y A;  1MIW A;  3LU6 A;  5IIX A;  3PLA A;  2VUE A;  1E7C A;  1LOT A;  4FK5 B;  4L9K A;  3KJL A;  4J2V A;  3NVM A;  1HK3 A;  4ZBR A;  1HK5 A;  3SIU B;  4IW2 A;  4FIP B;  5B5T A;  2EFE A;  4IW1 A;  4GDL B;  3GA9 L;  1E7G A;  4PO0 A;  4Z69 A;  2BX8 A;  1E7B A;  2BXI A;  2XVV A;  1VFI A;  2I30 A;  1O9X A;  3KIK A;  1H5W A;  4TQ0 A;  2NQO A;  1J78 A;  2BXA A;  1BJ5 A;  3B9M A;  2BXN A;  2Z8I A;  2BXF A;  2DYM A;  4N0U D;  2ROH A;  2BXD A;  4OTT A;  1KXP D;  5IJE A;  1AO6 A;  4L9Q A;  3B9L A;  1E7A A;  2VUF A;  4L8U A;  1LNS A;  2BXH A;  4GG2 A;  2JUH A;  4F5U A;  1BKE A;  1MA9 A;  1GNI A;  1E78 A;  2BXE A;  4GDX A;  3NVI A;  5GIP A;  3A73 A;  1GNJ A;  2BXC A;  2DBU A;  4MBE C;  3UIV A;  3JRY A;  4E99 A;  2DG5 A;  2BXL A;  4F5T A;  2E0Y A;  1MIY A;  3CX9 A;  4BKE A;  4ZUX V;  1MIV A;  1E7E A;  2BXG A;  4C31 B;  2V36 A;  2XVQ A;  1TXU A;  3NMU A;  4LUH A;  2EFC A;  3FNM A;  3LU8 A;  5IJF A;  3VQI A;  2BXP A;  3V08 A;  3TDL A;  4G04 A;  1VZS A;  4HGK A;  1NT2 B;  4FJC B;  1H9Z A;  5IIH A;  1HK4 A;  5DBY A;  5FUO A;  4JK4 A;  2NNW A;  2DBW A;  5IIU A;  4WA6 B;  4OT2 A;  2BXM A;  4ZBK A;  1KW2 A;  3G9K D;  3MHS B;  2Z8J A;  4N0F D;  2BXB A;  1FOU A;  3M99 C;  4ZC6 A;  4GDK B;  2OT3 A;  2YDF A;  4OR0 A;  1TF0 A;  2DBX A;  4LB9 A;  4Z9O A;  2E0X A;  1J7E A;  5IFO A;  4EMX A;  4K71 A;  3GQU A;  1BM0 A;  2I2Z A;  2XMO A;  2QMC A;  4N3Z A;  3NVK A;  4G01 A;  1E7H A;  5D7G A;  2DYO A;  2Z8K A;  2BXQ A;  4HGM B;  2XVU A;  2QHB A;  2QM6 A;  2XW0 A;  5GIN A;  1E7F A;  3MHH B;  4K2C A;  5ID9 A;  3LU7 A;  5GHK A;  2AJE A;  2CKX A;  3V09 A;  1IJG A;  1UOR A;  3FWC C;  4M70 B;  4G03 A;  3JQZ A;  2XSI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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