2I2ZA

Human serum albumin complexed with myristate and aspirin
Total Genus 220
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
220
sequence length
582
structure length
581
Chain Sequence
HKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Effect of human serum albumin on drug metabolism: Structural evidence of esterase activity of human serum albumin
pubmed doi rcsb
molecule tags Lipid binding protein
molecule keywords Serum albumin
total genus 220
structure length 581
sequence length 582
ec nomenclature
pdb deposition date 2006-08-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 2i2zA03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 2i2zA02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 2i2zA04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 2i2zA01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 2i2zA06
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 2i2zA05
1HK3A 4J2VA 2BXCA 4LUFA 2BXIA 3TDLA 1J7EA 4LB9A 2BXPA 1GNJA 2BXNA 1HK5A 4L9QA 4IW1A 2YDFA 3B9MA 3JRYA 3LU8A 1KXPD 3V03A 1E7BA 1KW2A 2I30A 4L8UA 4HGKA 1BM0A 1E7CA 3V09A 5IIXA 5IIUA 3LU6A 4IW2A 4ZBRA 3UIVA 2BXDA 5IJEA 5DBYA 4K71A 3V08A 3CX9A 2XSIA 4JK4A 2XW1A 2BXEA 2XVUA 2VDBA 4Z69A 3A73A 4G04A 1UORA 5HOZA 1E78A 2BXBA 4LUHA 1TF0A 2BXLA 5IJ5A 1N5UA 2BXGA 2XW0A 1HK1A 4ZBQA 1HA2A 2XVWA 4OR0A 4S1YA 1AO6A 1E7EA 4N0FD 1HK2A 4BKEA 5IIHA 2BXFA 4E99A 4PO0A 1H9ZA 2XVVA 5IFOA 1E7FA 4L9KA 5ID7A 1MA9A 5GHKA 1LOTA 1E7AA 1E7HA 1GNIA 2BXHA 5FUOA 4F5UA 2BXMA 4LA0A 2XVQA 2BXKA 4EMXA 4OT2A 4LB2A 4F5VA 5IJFA 1BKEA 4K2CA 4HGMB 3LU7A 1BJ5A 2BXQA 4F5SA 2BX8A 2BXAA 1O9XA 2I2ZA 2VUFA 3SQJA 1J78A 4N0UD 1E7GA 5DQFA 3JQZA 1E7IA 4F5TA 5ID9A 1HK4A 2BXOA 2VUEA 4G03A 3B9LA
chains in the Genus database with same CATH superfamily
5B5TA 1HK3A 4J2VA 5BPKA 2K0NA 2BXCA 4LUFA 2BXIA 3TDLA 1J7EA 4LB9A 2BXPA 1SB0A 1GNJA 3W1SA 3PLAA 2BXNA 3MHHB 1HK5A 4L9QA 4IW1A 2YDFA 3B9MA 3JRYA 3LU8A 1VFIA 1KXPD 3MHSB 3V03A 1E7BA 3H37A 1KW2A 2GUTA 2I30A 3A75A 4I9OA 4L8UA 1IJGA 3M99C 2DBWA 4HGKA 4ZC6A 4GG2A 1BM0A 1E7CA 3V09A 5IIXA 3GQUA 3KJLA 5IIUA 3LU6A 3NVKA 2QMCA 3VQIA 4IW2A 3NVMA 4GDKB 4ZCGA 4ZBRA 3UIVA 4C31B 4DM0A 2BXDA 4NAWB 5IJEA 5DBYA 3FNMA 1NT2B 2JUHA 3GQXA 4K71A 3V08A 2LQHA 3GA9L 1TXUA 3CX9A 2LXTA 2XSIA 4JK4A 1MIYA 2E0XA 2EFEA 4ZBKA 3WHSA 4ZUXV 2Z8JA 1MIWA 5GINA 2XW1A 2BXEA 2XVUA 2VDBA 4Z69A 3A73A 4G04A 2DYOA 3ICXA 3WHRA 1UORA 5HOZA 3NVIA 4N3ZA 2OT3A 1E78A 2BXBA 4LUHA 2Z8KA 2KWFA 2LQIA 4D7XA 1TF0A 2DBUA 2BXLA 5IJ5A 5GIOA 1N5UA 2BXGA 2EFCA 1FOUA 4GDLB 2XW0A 1HK1A 4G01A 4ZBQA 4TQ0A 3WHQA 2NQOA 4OTUA 1HA2A 2DBXA 2XVWA 4OR0A 4S1YA 1E7EA 2DYMA 2KBZA 4N0FD 1HK2A 4BKEA 1AO6A 2CKXA 5IIHA 2BXFA 2LOQA 2V36A 4FK5B 3SIUB 4FIPB 3FWCC 4E99A 4PO0A 1JNBA 1H9ZA 2XVVA 4G03A 2AGHB 5IFOA 1MM8A 1E7FA 4L9KA 5ID7A 1MA9A 2ROHA 4Z9OA 3H3AA 5GHKA 5D7GA 1LOTA 1E7AA 1E7HA 4TQ1A 1GNIA 2BXHA 5FUOA 4F5UA 2BXMA 1LNSA 1H5WA 1MUSA 4LA0A 2EFHA 2XVQA 2BXKA 2QM6A 4W4UB 4EMXA 4OT2A 4BY9C 5GIPA 4LB2A 4F5VA 3KIKA 5IJFA 4M70B 1BKEA 3SIVB 3BPJA 4K2CA 2AJEA 4FJCB 4GDXA 4HGMB 2NNWA 3LU7A 1BJ5A 2OZBB 2BXQA 4F5SA 2BXAA 4DHXB 1O9XA 2XMOA 2LXSA 3G9KD 2I2ZA 2VUFA 1MUHA 3SQJA 3NMUA 2EFDA 4MBEC 1J78A 4N0UD 3ECPA 1VZSA 1E7GA 4WA6B 4OTTA 5DQFA 3JQZA 1E7IA 4F5TA 1MIVA 1HK4A 5ID9A 2Z8IA 3FWBC 1KDXA 2BXOA 2VUEA 2DG5A 2BX8A 3B9LA 2E0YA 2QHBA
chains in the Genus database with same CATH topology
5B5TA 1HK3A 4J2VA 5BPKA 2BXCA 4LUFA 2BXIA 3TDLA 1J7EA 4LB9A 2BXPA 3W1SA 1GNJA 3PLAA 2BXNA 3MHHB 1HK5A 4L9QA 4IW1A 2YDFA 3B9MA 3JRYA 3LU8A 1VFIA 1KXPD 3MHSB 3V03A 1E7BA 3H37A 1KW2A 2I30A 3A75A 4L8UA 1IJGA 3M99C 2DBWA 4HGKA 4ZC6A 4GG2A 1BM0A 1E7CA 3V09A 5IIXA 3GQUA 3KJLA 5IIUA 3LU6A 3NVKA 2QMCA 3VQIA 4IW2A 3NVMA 4GDKB 4ZCGA 4ZBRA 3UIVA 4C31B 2BXDA 4NAWB 5IJEA 5DBYA 3FNMA 1NT2B 2JUHA 3GQXA 4K71A 3V08A 3GA9L 1TXUA 3CX9A 2XSIA 4JK4A 1MIYA 2E0XA 2EFEA 4ZBKA 3WHSA 4ZUXV 2Z8JA 1MIWA 5GINA 2XW1A 2BXEA 2XVUA 2VDBA 4Z69A 3A73A 4G04A 2DYOA 3ICXA 3WHRA 1UORA 5HOZA 3NVIA 4N3ZA 2OT3A 1E78A 2BXBA 4LUHA 2Z8KA 1TF0A 2DBUA 2BXLA 5IJ5A 5GIOA 1N5UA 2BXGA 2EFCA 1FOUA 4GDLB 2XW0A 1HK1A 4G01A 4ZBQA 4TQ0A 3WHQA 2NQOA 4OTUA 1HA2A 2DBXA 2XVWA 4OR0A 4S1YA 1E7EA 2DYMA 2KBZA 4N0FD 1HK2A 4BKEA 1AO6A 2CKXA 5IIHA 2BXFA 2LOQA 2V36A 4FK5B 3SIUB 4FIPB 3FWCC 4E99A 4PO0A 1JNBA 1H9ZA 2XVVA 4G03A 5IFOA 1E7FA 4L9KA 5ID7A 1MA9A 2ROHA 4Z9OA 3H3AA 5GHKA 5D7GA 1LOTA 1E7AA 1E7HA 4TQ1A 1GNIA 2BXHA 5FUOA 4F5UA 2BXMA 1LNSA 1H5WA 4LA0A 2EFHA 2XVQA 2BXKA 2QM6A 4W4UB 4EMXA 4OT2A 4BY9C 5GIPA 4LB2A 4F5VA 3KIKA 5IJFA 4M70B 1BKEA 3SIVB 4K2CA 2AJEA 4FJCB 4GDXA 4HGMB 2NNWA 3LU7A 1BJ5A 2OZBB 2BXQA 4F5SA 2BXAA 4DHXB 1O9XA 2XMOA 3G9KD 2I2ZA 2VUFA 3SQJA 3NMUA 2EFDA 4MBEC 1J78A 4N0UD 1VZSA 1E7GA 4WA6B 4OTTA 5DQFA 3JQZA 1E7IA 4F5TA 1MIVA 1HK4A 5ID9A 2Z8IA 3FWBC 2BXOA 2VUEA 2DG5A 2BX8A 3B9LA 2E0YA 2QHBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1HK3 A;  4J2V A;  2BXC A;  4LUF A;  2BXI A;  3TDL A;  1J7E A;  4LB9 A;  2BXP A;  1GNJ A;  2BXN A;  1HK5 A;  4L9Q A;  4IW1 A;  2YDF A;  3B9M A;  3JRY A;  3LU8 A;  1KXP D;  3V03 A;  1E7B A;  1KW2 A;  2I30 A;  4L8U A;  4HGK A;  1BM0 A;  1E7C A;  3V09 A;  5IIX A;  5IIU A;  3LU6 A;  4IW2 A;  4ZBR A;  3UIV A;  2BXD A;  5IJE A;  5DBY A;  4K71 A;  3V08 A;  3CX9 A;  2XSI A;  4JK4 A;  2XW1 A;  2BXE A;  2XVU A;  2VDB A;  4Z69 A;  3A73 A;  4G04 A;  1UOR A;  5HOZ A;  1E78 A;  2BXB A;  4LUH A;  1TF0 A;  2BXL A;  5IJ5 A;  1N5U A;  2BXG A;  2XW0 A;  1HK1 A;  4ZBQ A;  1HA2 A;  2XVW A;  4OR0 A;  4S1Y A;  1AO6 A;  1E7E A;  4N0F D;  1HK2 A;  4BKE A;  5IIH A;  2BXF A;  4E99 A;  4PO0 A;  1H9Z A;  2XVV A;  5IFO A;  1E7F A;  4L9K A;  5ID7 A;  1MA9 A;  5GHK A;  1LOT A;  1E7A A;  1E7H A;  1GNI A;  2BXH A;  5FUO A;  4F5U A;  2BXM A;  4LA0 A;  2XVQ A;  2BXK A;  4EMX A;  4OT2 A;  4LB2 A;  4F5V A;  5IJF A;  1BKE A;  4K2C A;  4HGM B;  3LU7 A;  1BJ5 A;  2BXQ A;  4F5S A;  2BX8 A;  2BXA A;  1O9X A;  2I2Z A;  2VUF A;  3SQJ A;  1J78 A;  4N0U D;  1E7G A;  5DQF A;  3JQZ A;  1E7I A;  4F5T A;  5ID9 A;  1HK4 A;  2BXO A;  2VUE A;  4G03 A;  3B9L A; 
#chains in the Genus database with same CATH topology
 5B5T A;  1HK3 A;  4J2V A;  5BPK A;  2K0N A;  2BXC A;  4LUF A;  2BXI A;  3TDL A;  1J7E A;  4LB9 A;  2BXP A;  1SB0 A;  1GNJ A;  3W1S A;  3PLA A;  2BXN A;  3MHH B;  1HK5 A;  4L9Q A;  4IW1 A;  2YDF A;  3B9M A;  3JRY A;  3LU8 A;  1VFI A;  1KXP D;  3MHS B;  3V03 A;  1E7B A;  3H37 A;  1KW2 A;  2GUT A;  2I30 A;  3A75 A;  4I9O A;  4L8U A;  1IJG A;  3M99 C;  2DBW A;  4HGK A;  4ZC6 A;  4GG2 A;  1BM0 A;  1E7C A;  3V09 A;  5IIX A;  3GQU A;  3KJL A;  5IIU A;  3LU6 A;  3NVK A;  2QMC A;  3VQI A;  4IW2 A;  3NVM A;  4GDK B;  4ZCG A;  4ZBR A;  3UIV A;  4C31 B;  4DM0 A;  2BXD A;  4NAW B;  5IJE A;  5DBY A;  3FNM A;  1NT2 B;  2JUH A;  3GQX A;  4K71 A;  3V08 A;  2LQH A;  3GA9 L;  1TXU A;  3CX9 A;  2LXT A;  2XSI A;  4JK4 A;  1MIY A;  2E0X A;  2EFE A;  4ZBK A;  3WHS A;  4ZUX V;  2Z8J A;  1MIW A;  5GIN A;  2XW1 A;  2BXE A;  2XVU A;  2VDB A;  4Z69 A;  3A73 A;  4G04 A;  2DYO A;  3ICX A;  3WHR A;  1UOR A;  5HOZ A;  3NVI A;  4N3Z A;  2OT3 A;  1E78 A;  2BXB A;  4LUH A;  2Z8K A;  2KWF A;  2LQI A;  4D7X A;  1TF0 A;  2DBU A;  2BXL A;  5IJ5 A;  5GIO A;  1N5U A;  2BXG A;  2EFC A;  1FOU A;  4GDL B;  2XW0 A;  1HK1 A;  4G01 A;  4ZBQ A;  4TQ0 A;  3WHQ A;  2NQO A;  4OTU A;  1HA2 A;  2DBX A;  2XVW A;  4OR0 A;  4S1Y A;  1E7E A;  2DYM A;  2KBZ A;  4N0F D;  1HK2 A;  4BKE A;  1AO6 A;  2CKX A;  5IIH A;  2BXF A;  2LOQ A;  2V36 A;  4FK5 B;  3SIU B;  4FIP B;  3FWC C;  4E99 A;  4PO0 A;  1JNB A;  1H9Z A;  2XVV A;  4G03 A;  2AGH B;  5IFO A;  1MM8 A;  1E7F A;  4L9K A;  5ID7 A;  1MA9 A;  2ROH A;  4Z9O A;  3H3A A;  5GHK A;  5D7G A;  1LOT A;  1E7A A;  1E7H A;  4TQ1 A;  1GNI A;  2BXH A;  5FUO A;  4F5U A;  2BXM A;  1LNS A;  1H5W A;  1MUS A;  4LA0 A;  2EFH A;  2XVQ A;  2BXK A;  2QM6 A;  4W4U B;  4EMX A;  4OT2 A;  4BY9 C;  5GIP A;  4LB2 A;  4F5V A;  3KIK A;  5IJF A;  4M70 B;  1BKE A;  3SIV B;  3BPJ A;  4K2C A;  2AJE A;  4FJC B;  4GDX A;  4HGM B;  2NNW A;  3LU7 A;  1BJ5 A;  2OZB B;  2BXQ A;  4F5S A;  2BXA A;  4DHX B;  1O9X A;  2XMO A;  2LXS A;  3G9K D;  2I2Z A;  2VUF A;  1MUH A;  3SQJ A;  3NMU A;  2EFD A;  4MBE C;  1J78 A;  4N0U D;  3ECP A;  1VZS A;  1E7G A;  4WA6 B;  4OTT A;  5DQF A;  3JQZ A;  1E7I A;  4F5T A;  1MIV A;  1HK4 A;  5ID9 A;  2Z8I A;  3FWB C;  1KDX A;  2BXO A;  2VUE A;  2DG5 A;  2BX8 A;  3B9L A;  2E0Y A;  2QHB A; 
#chains in the Genus database with same CATH homology
 5B5T A;  1HK3 A;  4J2V A;  5BPK A;  2BXC A;  4LUF A;  2BXI A;  3TDL A;  1J7E A;  4LB9 A;  2BXP A;  3W1S A;  1GNJ A;  3PLA A;  2BXN A;  3MHH B;  1HK5 A;  4L9Q A;  4IW1 A;  2YDF A;  3B9M A;  3JRY A;  3LU8 A;  1VFI A;  1KXP D;  3MHS B;  3V03 A;  1E7B A;  3H37 A;  1KW2 A;  2I30 A;  3A75 A;  4L8U A;  1IJG A;  3M99 C;  2DBW A;  4HGK A;  4ZC6 A;  4GG2 A;  1BM0 A;  1E7C A;  3V09 A;  5IIX A;  3GQU A;  3KJL A;  5IIU A;  3LU6 A;  3NVK A;  2QMC A;  3VQI A;  4IW2 A;  3NVM A;  4GDK B;  4ZCG A;  4ZBR A;  3UIV A;  4C31 B;  2BXD A;  4NAW B;  5IJE A;  5DBY A;  3FNM A;  1NT2 B;  2JUH A;  3GQX A;  4K71 A;  3V08 A;  3GA9 L;  1TXU A;  3CX9 A;  2XSI A;  4JK4 A;  1MIY A;  2E0X A;  2EFE A;  4ZBK A;  3WHS A;  4ZUX V;  2Z8J A;  1MIW A;  5GIN A;  2XW1 A;  2BXE A;  2XVU A;  2VDB A;  4Z69 A;  3A73 A;  4G04 A;  2DYO A;  3ICX A;  3WHR A;  1UOR A;  5HOZ A;  3NVI A;  4N3Z A;  2OT3 A;  1E78 A;  2BXB A;  4LUH A;  2Z8K A;  1TF0 A;  2DBU A;  2BXL A;  5IJ5 A;  5GIO A;  1N5U A;  2BXG A;  2EFC A;  1FOU A;  4GDL B;  2XW0 A;  1HK1 A;  4G01 A;  4ZBQ A;  4TQ0 A;  3WHQ A;  2NQO A;  4OTU A;  1HA2 A;  2DBX A;  2XVW A;  4OR0 A;  4S1Y A;  1E7E A;  2DYM A;  2KBZ A;  4N0F D;  1HK2 A;  4BKE A;  1AO6 A;  2CKX A;  5IIH A;  2BXF A;  2LOQ A;  2V36 A;  4FK5 B;  3SIU B;  4FIP B;  3FWC C;  4E99 A;  4PO0 A;  1JNB A;  1H9Z A;  2XVV A;  4G03 A;  5IFO A;  1E7F A;  4L9K A;  5ID7 A;  1MA9 A;  2ROH A;  4Z9O A;  3H3A A;  5GHK A;  5D7G A;  1LOT A;  1E7A A;  1E7H A;  4TQ1 A;  1GNI A;  2BXH A;  5FUO A;  4F5U A;  2BXM A;  1LNS A;  1H5W A;  4LA0 A;  2EFH A;  2XVQ A;  2BXK A;  2QM6 A;  4W4U B;  4EMX A;  4OT2 A;  4BY9 C;  5GIP A;  4LB2 A;  4F5V A;  3KIK A;  5IJF A;  4M70 B;  1BKE A;  3SIV B;  4K2C A;  2AJE A;  4FJC B;  4GDX A;  4HGM B;  2NNW A;  3LU7 A;  1BJ5 A;  2OZB B;  2BXQ A;  4F5S A;  2BXA A;  4DHX B;  1O9X A;  2XMO A;  3G9K D;  2I2Z A;  2VUF A;  3SQJ A;  3NMU A;  2EFD A;  4MBE C;  1J78 A;  4N0U D;  1VZS A;  1E7G A;  4WA6 B;  4OTT A;  5DQF A;  3JQZ A;  1E7I A;  4F5T A;  1MIV A;  1HK4 A;  5ID9 A;  2Z8I A;  3FWB C;  2BXO A;  2VUE A;  2DG5 A;  2BX8 A;  3B9L A;  2E0Y A;  2QHB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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