2KWFA

The structure of e-protein activation domain 1 bound to the kix domain of cbp/p300 elucidates leukemia induction by e2a-pbx1
Total Genus 25
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
87
structure length
87
Chain Sequence
GVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title The structure of E-protein activation domain 1 bound to the KIX domain of CBP/p300 elucidates leukemia induction by E2A-PBX1
rcsb
molecule tags Transcription
source organism Homo sapiens
molecule keywords CREB-binding protein
total genus 25
structure length 87
sequence length 87
ec nomenclature ec 2.3.1.48: Histone acetyltransferase.
pdb deposition date 2010-04-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02172 KIX KIX domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.20 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Coactivator CBP, KIX domain 2kwfA00
2KWFA 2LXTA 2LQIA 1SB0A 4I9OA 2LQHA 2LXSA 2GUTA 1KDXA 4D7XA 2AGHB 2K0NA
chains in the Genus database with same CATH superfamily
4G01A 1H9ZA 4ZBKA 1JNBA 1GNIA 1BKEA 5BPKA 2VUFA 2XVQA 3BPJA 4WA6B 4D7XA 5IJEA 5IIXA 1E7EA 3H3AA 4FJCB 1HK3A 2BXCA 1E7CA 2LOQA 2LXSA 1VZSA 4OTUA 5HOZA 2LXTA 1E78A 1TXUA 2Z8IA 1UORA 3MHSB 1MA9A 4MBEC 2BXLA 2LQHA 2XMOA 4Z9OA 4ZBRA 4F5VA 2BXPA 2DYOA 4LUFA 1N5UA 3G9KD 2LQIA 4GDLB 4JK4A 2EFCA 4N3ZA 3M99C 3SQJA 4OT2A 3CX9A 3WHSA 3PLAA 2AGHB 2CKXA 1E7FA 4OR0A 2BXHA 2E0YA 1HK5A 2VUEA 2BXBA 3LU6A 5GINA 1IJGA 3ECPA 2VDBA 4L8UA 5DQFA 3SIUB 3JRYA 1HA2A 1HK4A 2QMCA 2BXMA 3A73A 4G04A 4K2CA 4K71A 1MIVA 2QM6A 4LA0A 2QHBA 1MUHA 1SB0A 2I2ZA 4GDXA 2BXAA 3VQIA 4DHXB 4G03A 4ZUXV 2Z8KA 3WHQA 5D7GA 4S1YA 4ZBQA 2YDFA 3LU7A 1J78A 5IIUA 2BXNA 3MHHB 1E7IA 2BXEA 3ICXA 4W4UB 4BY9C 2V36A 4TQ1A 3NVKA 2XW1A 4LUHA 2OT3A 4GDKB 3WHRA 1KXPD 2BXQA 2GUTA 4E99A 2DBUA 5GIPA 2BX8A 2JUHA 3NMUA 3KIKA 3NVMA 4N0FD 2E0XA 5IFOA 3FNMA 2DBWA 2XW0A 4NAWB 2AJEA 2EFEA 1VFIA 2BXDA 1H5WA 4BKEA 4ZCGA 3FWBC 3V09A 4Z69A 4DM0A 2XVVA 3V08A 1E7GA 4M70B 5GIOA 1MUSA 1AO6A 5IJFA 2BXFA 2EFDA 4OTTA 3NVIA 4L9QA 4FK5B 2DBXA 3UIVA 2KWFA 3A75A 2NQOA 4F5TA 1LOTA 3JQZA 1J7EA 4LB9A 4L9KA 5IIHA 5ID7A 3GQUA 2BXOA 4N0UD 4ZC6A 2KBZA 1HK1A 1O9XA 2XVWA 3KJLA 4GG2A 4IW1A 1FOUA 5B5TA 4F5UA 4C31B 1TF0A 5ID9A 3B9MA 2I30A 2BXGA 3FWCC 2K0NA 2Z8JA 1MIYA 5GHKA 3TDLA 1HK2A 3GQXA 3W1SA 2BXIA 4FIPB 5DBYA 2XVUA 5FUOA 2XSIA 4F5SA 1E7AA 1LNSA 1BM0A 3V03A 1GNJA 2DYMA 1MM8A 4IW2A 4HGKA 4TQ0A 1E7BA 2DG5A 4LB2A 3GA9L 4PO0A 2NNWA 1KW2A 1E7HA 4I9OA 2OZBB 1NT2B 1KDXA 3SIVB 3LU8A 3H37A 1BJ5A 4EMXA 1MIWA 5IJ5A 4HGMB 2EFHA 2ROHA 2BXKA 3B9LA 4J2VA
chains in the Genus database with same CATH topology
2KWFA 2LXTA 2LQIA 1SB0A 4I9OA 2LQHA 2LXSA 2GUTA 1KDXA 4D7XA 2AGHB 2K0NA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2KWF A;  2LXT A;  2LQI A;  1SB0 A;  4I9O A;  2LQH A;  2LXS A;  2GUT A;  1KDX A;  4D7X A;  2AGH B;  2K0N A; 
#chains in the Genus database with same CATH topology
 4G01 A;  1H9Z A;  4ZBK A;  1JNB A;  1GNI A;  1BKE A;  5BPK A;  2VUF A;  2XVQ A;  3BPJ A;  4WA6 B;  4D7X A;  5IJE A;  5IIX A;  1E7E A;  3H3A A;  4FJC B;  1HK3 A;  2BXC A;  1E7C A;  2LOQ A;  2LXS A;  1VZS A;  4OTU A;  5HOZ A;  2LXT A;  1E78 A;  1TXU A;  2Z8I A;  1UOR A;  3MHS B;  1MA9 A;  4MBE C;  2BXL A;  2LQH A;  2XMO A;  4Z9O A;  4ZBR A;  4F5V A;  2BXP A;  2DYO A;  4LUF A;  1N5U A;  3G9K D;  2LQI A;  4GDL B;  4JK4 A;  2EFC A;  4N3Z A;  3M99 C;  3SQJ A;  4OT2 A;  3CX9 A;  3WHS A;  3PLA A;  2AGH B;  2CKX A;  1E7F A;  4OR0 A;  2BXH A;  2E0Y A;  1HK5 A;  2VUE A;  2BXB A;  3LU6 A;  5GIN A;  1IJG A;  3ECP A;  2VDB A;  4L8U A;  5DQF A;  3SIU B;  3JRY A;  1HA2 A;  1HK4 A;  2QMC A;  2BXM A;  3A73 A;  4G04 A;  4K2C A;  4K71 A;  1MIV A;  2QM6 A;  4LA0 A;  2QHB A;  1MUH A;  1SB0 A;  2I2Z A;  4GDX A;  2BXA A;  3VQI A;  4DHX B;  4G03 A;  4ZUX V;  2Z8K A;  3WHQ A;  5D7G A;  4S1Y A;  4ZBQ A;  2YDF A;  3LU7 A;  1J78 A;  5IIU A;  2BXN A;  3MHH B;  1E7I A;  2BXE A;  3ICX A;  4W4U B;  4BY9 C;  2V36 A;  4TQ1 A;  3NVK A;  2XW1 A;  4LUH A;  2OT3 A;  4GDK B;  3WHR A;  1KXP D;  2BXQ A;  2GUT A;  4E99 A;  2DBU A;  5GIP A;  2BX8 A;  2JUH A;  3NMU A;  3KIK A;  3NVM A;  4N0F D;  2E0X A;  5IFO A;  3FNM A;  2DBW A;  2XW0 A;  4NAW B;  2AJE A;  2EFE A;  1VFI A;  2BXD A;  1H5W A;  4BKE A;  4ZCG A;  3FWB C;  3V09 A;  4Z69 A;  4DM0 A;  2XVV A;  3V08 A;  1E7G A;  4M70 B;  5GIO A;  1MUS A;  1AO6 A;  5IJF A;  2BXF A;  2EFD A;  4OTT A;  3NVI A;  4L9Q A;  4FK5 B;  2DBX A;  3UIV A;  2KWF A;  3A75 A;  2NQO A;  4F5T A;  1LOT A;  3JQZ A;  1J7E A;  4LB9 A;  4L9K A;  5IIH A;  5ID7 A;  3GQU A;  2BXO A;  4N0U D;  4ZC6 A;  2KBZ A;  1HK1 A;  1O9X A;  2XVW A;  3KJL A;  4GG2 A;  4IW1 A;  1FOU A;  5B5T A;  4F5U A;  4C31 B;  1TF0 A;  5ID9 A;  3B9M A;  2I30 A;  2BXG A;  3FWC C;  2K0N A;  2Z8J A;  1MIY A;  5GHK A;  3TDL A;  1HK2 A;  3GQX A;  3W1S A;  2BXI A;  4FIP B;  5DBY A;  2XVU A;  5FUO A;  2XSI A;  4F5S A;  1E7A A;  1LNS A;  1BM0 A;  3V03 A;  1GNJ A;  2DYM A;  1MM8 A;  4IW2 A;  4HGK A;  4TQ0 A;  1E7B A;  2DG5 A;  4LB2 A;  3GA9 L;  4PO0 A;  2NNW A;  1KW2 A;  1E7H A;  4I9O A;  2OZB B;  1NT2 B;  1KDX A;  3SIV B;  3LU8 A;  3H37 A;  1BJ5 A;  4EMX A;  1MIW A;  5IJ5 A;  4HGM B;  2EFH A;  2ROH A;  2BXK A;  3B9L A;  4J2V A; 
#chains in the Genus database with same CATH homology
 2KWF A;  2LXT A;  2LQI A;  1SB0 A;  4I9O A;  2LQH A;  2LXS A;  2GUT A;  1KDX A;  4D7X A;  2AGH B;  2K0N A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...