2LXSA

Allosteric communication in the kix domain proceeds through dynamic re-packing of the hydrophobic core
Total Genus 30
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
30
sequence length
87
structure length
87
Chain Sequence
GVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Allosteric Communication in the KIX Domain Proceeds through Dynamic Repacking of the Hydrophobic Core.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords CREB-binding protein
total genus 30
structure length 87
sequence length 87
ec nomenclature ec 2.3.1.48: Histone acetyltransferase.
pdb deposition date 2012-08-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02172 KIX KIX domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.20 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Coactivator CBP, KIX domain 2lxsA00
2KWFA 4I9OA 1KDXA 2LQIA 1SB0A 2K0NA 4D7XA 2AGHB 2LXTA 2GUTA 2LQHA 2LXSA
chains in the Genus database with same CATH superfamily
3MHSB 4ZC6A 3NVIA 3BPJA 5DBYA 1GNIA 4FJCB 3NMUA 2AGHB 4TQ1A 4S1YA 5GIPA 1MIWA 3JQZA 3PLAA 4G01A 1GNJA 4EMXA 3M99C 4M70B 4ZBRA 1BKEA 5B5TA 4G03A 1LOTA 3SIVB 4IW2A 4BY9C 2K0NA 5IIUA 5IIHA 4W4UB 2XVWA 4K71A 2LQHA 3H37A 4IW1A 2LXSA 1E7BA 2LQIA 4BKEA 3KIKA 1HK1A 1MUSA 3V03A 2BX8A 4F5SA 2DBUA 1E7CA 3V09A 1HK5A 2VUEA 1J7EA 3B9LA 3SQJA 2BXNA 2Z8JA 4HGKA 4L8UA 5FUOA 3SIUB 4HGMB 2DBXA 1N5UA 2DBWA 2JUHA 4K2CA 5IFOA 1HK4A 1KW2A 1E7IA 3W1SA 2VDBA 1BM0A 2BXIA 4L9KA 2EFHA 4N0UD 2BXMA 2OT3A 3KJLA 4TQ0A 4ZUXV 4ZBQA 1E7FA 2I30A 4ZBKA 2BXDA 2Z8KA 4FIPB 4FK5B 2EFDA 5BPKA 3NVKA 1J78A 2XVQA 4GDXA 2YDFA 3TDLA 1H9ZA 2VUFA 2BXBA 2E0XA 5IJ5A 3UIVA 2CKXA 1VFIA 2BXOA 1KXPD 1E7GA 1MIVA 2BXQA 4GDKB 3B9MA 4NAWB 4OTUA 4OT2A 5D7GA 3GQXA 3FNMA 3H3AA 4DM0A 4LUHA 1SB0A 4E99A 5GINA 5IIXA 1E7EA 2BXPA 2LXTA 3FWCC 5HOZA 4GG2A 2NNWA 2QM6A 2V36A 1KDXA 3ECPA 3V08A 3G9KD 3NVMA 2ROHA 2XW0A 4ZCGA 4LA0A 5GIOA 3LU8A 2BXKA 1HK2A 2DYOA 3VQIA 5DQFA 4F5UA 2DYMA 2EFCA 2NQOA 2XSIA 4LB9A 1E7AA 3A73A 4LB2A 3WHRA 1MUHA 2XVUA 1VZSA 4Z69A 2I2ZA 2DG5A 2XMOA 4I9OA 1NT2B 4MBEC 3MHHB 5IJEA 2E0YA 1MIYA 2BXFA 2BXCA 4N0FD 4GDLB 5IJFA 2QHBA 1HA2A 2XVVA 4N3ZA 3A75A 3GA9L 1FOUA 2BXLA 1E78A 2QMCA 3WHQA 3FWBC 2OZBB 1O9XA 2BXAA 3CX9A 1LNSA 1TF0A 3ICXA 5ID7A 5ID9A 2GUTA 3WHSA 1E7HA 3LU6A 4LUFA 2XW1A 5GHKA 4WA6B 2KWFA 1H5WA 4C31B 4L9QA 1BJ5A 2KBZA 2EFEA 3JRYA 1IJGA 2BXGA 2LOQA 4F5VA 1MA9A 2AJEA 1TXUA 1UORA 2Z8IA 4D7XA 4DHXB 1AO6A 4G04A 2BXHA 1HK3A 3GQUA 3LU7A 4JK4A 4OR0A 4F5TA 1MM8A 4J2VA 2BXEA 4OTTA 4PO0A 4Z9OA 1JNBA
chains in the Genus database with same CATH topology
2KWFA 4I9OA 1KDXA 2LQIA 1SB0A 2K0NA 4D7XA 2AGHB 2LXTA 2GUTA 2LQHA 2LXSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2KWF A;  4I9O A;  1KDX A;  2LQI A;  1SB0 A;  2K0N A;  4D7X A;  2AGH B;  2LXT A;  2GUT A;  2LQH A;  2LXS A; 
#chains in the Genus database with same CATH topology
 3MHS B;  4ZC6 A;  3NVI A;  3BPJ A;  5DBY A;  1GNI A;  4FJC B;  3NMU A;  2AGH B;  4TQ1 A;  4S1Y A;  5GIP A;  1MIW A;  3JQZ A;  3PLA A;  4G01 A;  1GNJ A;  4EMX A;  3M99 C;  4M70 B;  4ZBR A;  1BKE A;  5B5T A;  4G03 A;  1LOT A;  3SIV B;  4IW2 A;  4BY9 C;  2K0N A;  5IIU A;  5IIH A;  4W4U B;  2XVW A;  4K71 A;  2LQH A;  3H37 A;  4IW1 A;  2LXS A;  1E7B A;  2LQI A;  4BKE A;  3KIK A;  1HK1 A;  1MUS A;  3V03 A;  2BX8 A;  4F5S A;  2DBU A;  1E7C A;  3V09 A;  1HK5 A;  2VUE A;  1J7E A;  3B9L A;  3SQJ A;  2BXN A;  2Z8J A;  4HGK A;  4L8U A;  5FUO A;  3SIU B;  4HGM B;  2DBX A;  1N5U A;  2DBW A;  2JUH A;  4K2C A;  5IFO A;  1HK4 A;  1KW2 A;  1E7I A;  3W1S A;  2VDB A;  1BM0 A;  2BXI A;  4L9K A;  2EFH A;  4N0U D;  2BXM A;  2OT3 A;  3KJL A;  4TQ0 A;  4ZUX V;  4ZBQ A;  1E7F A;  2I30 A;  4ZBK A;  2BXD A;  2Z8K A;  4FIP B;  4FK5 B;  2EFD A;  5BPK A;  3NVK A;  1J78 A;  2XVQ A;  4GDX A;  2YDF A;  3TDL A;  1H9Z A;  2VUF A;  2BXB A;  2E0X A;  5IJ5 A;  3UIV A;  2CKX A;  1VFI A;  2BXO A;  1KXP D;  1E7G A;  1MIV A;  2BXQ A;  4GDK B;  3B9M A;  4NAW B;  4OTU A;  4OT2 A;  5D7G A;  3GQX A;  3FNM A;  3H3A A;  4DM0 A;  4LUH A;  1SB0 A;  4E99 A;  5GIN A;  5IIX A;  1E7E A;  2BXP A;  2LXT A;  3FWC C;  5HOZ A;  4GG2 A;  2NNW A;  2QM6 A;  2V36 A;  1KDX A;  3ECP A;  3V08 A;  3G9K D;  3NVM A;  2ROH A;  2XW0 A;  4ZCG A;  4LA0 A;  5GIO A;  3LU8 A;  2BXK A;  1HK2 A;  2DYO A;  3VQI A;  5DQF A;  4F5U A;  2DYM A;  2EFC A;  2NQO A;  2XSI A;  4LB9 A;  1E7A A;  3A73 A;  4LB2 A;  3WHR A;  1MUH A;  2XVU A;  1VZS A;  4Z69 A;  2I2Z A;  2DG5 A;  2XMO A;  4I9O A;  1NT2 B;  4MBE C;  3MHH B;  5IJE A;  2E0Y A;  1MIY A;  2BXF A;  2BXC A;  4N0F D;  4GDL B;  5IJF A;  2QHB A;  1HA2 A;  2XVV A;  4N3Z A;  3A75 A;  3GA9 L;  1FOU A;  2BXL A;  1E78 A;  2QMC A;  3WHQ A;  3FWB C;  2OZB B;  1O9X A;  2BXA A;  3CX9 A;  1LNS A;  1TF0 A;  3ICX A;  5ID7 A;  5ID9 A;  2GUT A;  3WHS A;  1E7H A;  3LU6 A;  4LUF A;  2XW1 A;  5GHK A;  4WA6 B;  2KWF A;  1H5W A;  4C31 B;  4L9Q A;  1BJ5 A;  2KBZ A;  2EFE A;  3JRY A;  1IJG A;  2BXG A;  2LOQ A;  4F5V A;  1MA9 A;  2AJE A;  1TXU A;  1UOR A;  2Z8I A;  4D7X A;  4DHX B;  1AO6 A;  4G04 A;  2BXH A;  1HK3 A;  3GQU A;  3LU7 A;  4JK4 A;  4OR0 A;  4F5T A;  1MM8 A;  4J2V A;  2BXE A;  4OTT A;  4PO0 A;  4Z9O A;  1JNB A; 
#chains in the Genus database with same CATH homology
 2KWF A;  4I9O A;  1KDX A;  2LQI A;  1SB0 A;  2K0N A;  4D7X A;  2AGH B;  2LXT A;  2GUT A;  2LQH A;  2LXS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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