2LXTA

Allosteric communication in the kix domain proceeds through dynamic re-packing of the hydrophobic core
Total Genus 29
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
29
sequence length
87
structure length
87
Chain Sequence
GVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Allosteric Communication in the KIX Domain Proceeds through Dynamic Repacking of the Hydrophobic Core.
pubmed doi rcsb
molecule tags Transferase/protein binding
source organism Homo sapiens
molecule keywords CREB-binding protein
total genus 29
structure length 87
sequence length 87
ec nomenclature ec 2.3.1.48: Histone acetyltransferase.
pdb deposition date 2012-08-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02172 KIX KIX domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.20 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Coactivator CBP, KIX domain 2lxtA00
2LQHA 2GUTA 2AGHB 2LXSA 4I9OA 1KDXA 2LQIA 4D7XA 2LXTA 2KWFA 1SB0A 2K0NA
chains in the Genus database with same CATH superfamily
5IJFA 3LU8A 4K71A 1E78A 4HGKA 2DBWA 4W4UB 4BY9C 5ID7A 5IIHA 2XVWA 2BXAA 3JQZA 3FWBC 4FJCB 2E0YA 4C31B 1MIVA 4PO0A 2QMCA 3WHQA 5B5TA 5ID9A 3PLAA 3M99C 2CKXA 3SIVB 1HK2A 3KJLA 4ZCGA 4BKEA 2BX8A 2LOQA 4MBEC 1J78A 3NVIA 1GNJA 2BXMA 3MHSB 4L9KA 4OTTA 2EFEA 1HK5A 2YDFA 4LB2A 3WHRA 3LU6A 4FK5B 3H3AA 3BPJA 2LXTA 4Z69A 4J2VA 5FUOA 5IJ5A 2LQHA 4G04A 4LA0A 5IIUA 5IIXA 2EFDA 1KW2A 2XW0A 2AGHB 4TQ1A 4N3ZA 1MUSA 2EFCA 5DQFA 2K0NA 3WHSA 1LOTA 1E7GA 4GDLB 2LXSA 2BXOA 4WA6B 3ECPA 3UIVA 4G03A 2BXDA 4HGMB 1H5WA 4ZBKA 4M70B 4Z9OA 1E7HA 3MHHB 4LUHA 2GUTA 2BXKA 1BJ5A 2DYOA 4E99A 2XVUA 1E7AA 1E7EA 2V36A 4OT2A 1JNBA 4L8UA 3V09A 3B9LA 2NNWA 3CX9A 4IW1A 2EFHA 4ZC6A 2DBXA 4DM0A 2OZBB 1E7CA 2JUHA 1KXPD 2QHBA 4N0FD 1IJGA 2LQIA 3H37A 1TXUA 1SB0A 1HK4A 2BXGA 1MIWA 4ZBQA 4LB9A 3JRYA 2BXQA 1N5UA 2Z8IA 3NMUA 1E7FA 2VDBA 2VUFA 3SIUB 2XVQA 2Z8KA 3LU7A 1HA2A 4IW2A 2I30A 5IJEA 4F5TA 1TF0A 1MM8A 4I9OA 2BXIA 1BM0A 2BXFA 5D7GA 2OT3A 1E7IA 2BXHA 4F5VA 3NVKA 2BXLA 2BXNA 2KBZA 4JK4A 4OTUA 3ICXA 1BKEA 1MA9A 3V08A 2BXBA 2XW1A 1HK3A 4FIPB 4LUFA 5IFOA 3B9MA 3A73A 2KWFA 2BXCA 4K2CA 2ROHA 5GIPA 1H9ZA 1J7EA 4OR0A 4G01A 2BXEA 1MIYA 1GNIA 1VZSA 3TDLA 2VUEA 2DBUA 3G9KD 4GDKB 4GDXA 5DBYA 4DHXB 1UORA 2XVVA 5GIOA 3A75A 1NT2B 3FNMA 4ZBRA 3V03A 1MUHA 4F5SA 2DYMA 2XMOA 4N0UD 3NVMA 4F5UA 3VQIA 2Z8JA 2QM6A 3GQUA 1O9XA 3GA9L 5GHKA 2BXPA 3GQXA 1HK1A 1KDXA 3SQJA 3FWCC 4GG2A 5BPKA 1AO6A 2AJEA 4L9QA 4ZUXV 4D7XA 1VFIA 5GINA 5HOZA 1E7BA 4TQ0A 2NQOA 1LNSA 4NAWB 2I2ZA 4S1YA 3KIKA 2DG5A 3W1SA 1FOUA 4EMXA 2XSIA 2E0XA
chains in the Genus database with same CATH topology
2LQHA 2GUTA 2AGHB 2LXSA 4I9OA 1KDXA 2LQIA 4D7XA 2LXTA 2KWFA 1SB0A 2K0NA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2LQH A;  2GUT A;  2AGH B;  2LXS A;  4I9O A;  1KDX A;  2LQI A;  4D7X A;  2LXT A;  2KWF A;  1SB0 A;  2K0N A; 
#chains in the Genus database with same CATH topology
 5IJF A;  3LU8 A;  4K71 A;  1E78 A;  4HGK A;  2DBW A;  4W4U B;  4BY9 C;  5ID7 A;  5IIH A;  2XVW A;  2BXA A;  3JQZ A;  3FWB C;  4FJC B;  2E0Y A;  4C31 B;  1MIV A;  4PO0 A;  2QMC A;  3WHQ A;  5B5T A;  5ID9 A;  3PLA A;  3M99 C;  2CKX A;  3SIV B;  1HK2 A;  3KJL A;  4ZCG A;  4BKE A;  2BX8 A;  2LOQ A;  4MBE C;  1J78 A;  3NVI A;  1GNJ A;  2BXM A;  3MHS B;  4L9K A;  4OTT A;  2EFE A;  1HK5 A;  2YDF A;  4LB2 A;  3WHR A;  3LU6 A;  4FK5 B;  3H3A A;  3BPJ A;  2LXT A;  4Z69 A;  4J2V A;  5FUO A;  5IJ5 A;  2LQH A;  4G04 A;  4LA0 A;  5IIU A;  5IIX A;  2EFD A;  1KW2 A;  2XW0 A;  2AGH B;  4TQ1 A;  4N3Z A;  1MUS A;  2EFC A;  5DQF A;  2K0N A;  3WHS A;  1LOT A;  1E7G A;  4GDL B;  2LXS A;  2BXO A;  4WA6 B;  3ECP A;  3UIV A;  4G03 A;  2BXD A;  4HGM B;  1H5W A;  4ZBK A;  4M70 B;  4Z9O A;  1E7H A;  3MHH B;  4LUH A;  2GUT A;  2BXK A;  1BJ5 A;  2DYO A;  4E99 A;  2XVU A;  1E7A A;  1E7E A;  2V36 A;  4OT2 A;  1JNB A;  4L8U A;  3V09 A;  3B9L A;  2NNW A;  3CX9 A;  4IW1 A;  2EFH A;  4ZC6 A;  2DBX A;  4DM0 A;  2OZB B;  1E7C A;  2JUH A;  1KXP D;  2QHB A;  4N0F D;  1IJG A;  2LQI A;  3H37 A;  1TXU A;  1SB0 A;  1HK4 A;  2BXG A;  1MIW A;  4ZBQ A;  4LB9 A;  3JRY A;  2BXQ A;  1N5U A;  2Z8I A;  3NMU A;  1E7F A;  2VDB A;  2VUF A;  3SIU B;  2XVQ A;  2Z8K A;  3LU7 A;  1HA2 A;  4IW2 A;  2I30 A;  5IJE A;  4F5T A;  1TF0 A;  1MM8 A;  4I9O A;  2BXI A;  1BM0 A;  2BXF A;  5D7G A;  2OT3 A;  1E7I A;  2BXH A;  4F5V A;  3NVK A;  2BXL A;  2BXN A;  2KBZ A;  4JK4 A;  4OTU A;  3ICX A;  1BKE A;  1MA9 A;  3V08 A;  2BXB A;  2XW1 A;  1HK3 A;  4FIP B;  4LUF A;  5IFO A;  3B9M A;  3A73 A;  2KWF A;  2BXC A;  4K2C A;  2ROH A;  5GIP A;  1H9Z A;  1J7E A;  4OR0 A;  4G01 A;  2BXE A;  1MIY A;  1GNI A;  1VZS A;  3TDL A;  2VUE A;  2DBU A;  3G9K D;  4GDK B;  4GDX A;  5DBY A;  4DHX B;  1UOR A;  2XVV A;  5GIO A;  3A75 A;  1NT2 B;  3FNM A;  4ZBR A;  3V03 A;  1MUH A;  4F5S A;  2DYM A;  2XMO A;  4N0U D;  3NVM A;  4F5U A;  3VQI A;  2Z8J A;  2QM6 A;  3GQU A;  1O9X A;  3GA9 L;  5GHK A;  2BXP A;  3GQX A;  1HK1 A;  1KDX A;  3SQJ A;  3FWC C;  4GG2 A;  5BPK A;  1AO6 A;  2AJE A;  4L9Q A;  4ZUX V;  4D7X A;  1VFI A;  5GIN A;  5HOZ A;  1E7B A;  4TQ0 A;  2NQO A;  1LNS A;  4NAW B;  2I2Z A;  4S1Y A;  3KIK A;  2DG5 A;  3W1S A;  1FOU A;  4EMX A;  2XSI A;  2E0X A; 
#chains in the Genus database with same CATH homology
 2LQH A;  2GUT A;  2AGH B;  2LXS A;  4I9O A;  1KDX A;  2LQI A;  4D7X A;  2LXT A;  2KWF A;  1SB0 A;  2K0N A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...