4E9EA

Structure of the glycosylase domain of mbd4
Total Genus 45
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
45
sequence length
140
structure length
140
Chain Sequence
KWTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEDHKLNKYHDWLWENHEK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Methyl-CpG-binding domain protein 4
publication title Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 45
structure length 140
sequence length 140
ec nomenclature ec 3.2.2.-:
pdb deposition date 2012-03-21
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4e9eA00
4UNFA 3FSPA 1VRLA 1MPGA 1KG2A 4HSBA 4E9GA 2YG8A 1LWWA 1KG6A 4EVVA 1KO9A 4OFHA 4EA5A 1M3QA 2XHIA 3I0WA 2ABKA 1LWVA 1KG7A 3CVSA 1XQOA 1PU8A 1LMZA 2OFKA 4EW0A 3FHGA 1N3AA 3F0ZA 1KG5A 4B22A 4EA4A 3FHFA 3S6IA 2H56A 1YQRA 3N5NX 5CHZA 1N39A 4EJZA 4E9EA 4AIAA 4E9HA 1P7MA 4OFAA 5KN8A 1YQLA 4YPHA 1NKUA 1M3HA 3CVTA 4AI5A 1YQMA 2NOZA 5KN9A 3CWSA 1P59A 2JHNA 1PU7A 3OH6A 2JG6A 4OFEA 5DPKA 1XG7A 1KG3A 3IH7A 4EJYA 1PVSA 3CWAA 3CW7A 4B21A 1YQKA 4PIIA 1ORNA 1HU0A 3OGDA 1KEAA 2OFIA 2NOFA 3KTUA 2NOBA 1EBMA 4B24A 2NOLA 1MUNA 3D4VA 3I0XA 4DK9A 2NOEA 1NGNA 3CWTA 2JHJA 5AN4A 3KNTA 4B23A 1RRQA 1KG4A 1WEFA 2YG9A 3IHOA 4EW4A 3OH9A 1PU6A 2NOHA 4AI4A 1MUDA 4YPRA 1KQJA 1DIZA 1ORPA 4YOQA 1N3CA 1WEGA 1FN7A 1LWYA 1MUYA 2I5WA 1XQPA 3N0UA 2NOIA 3G0QA 3F10A 4UOBA 1WEIA 1RRSA 4E9FA 3CWUA
chains in the Genus database with same CATH superfamily
4UNFA 3LCNA 3FSPA 4ZTFA 1VRLA 1MPGA 1KG2A 4HSBA 4E9GA 2YG8A 2JPSA 1LWWA 1KG6A 4EVVA 1KO9A 4OFHA 4NZGA 4EA5A 1M3QA 2XHIA 3I0WA 4E7JA 3OYGA 2W04A 2ABKA 1LWVA 3S3NA 1KG7A 3CVSA 3OYLA 1XQOA 1PU8A 3OYJA 1LMZA 2OFKA 4EW0A 2W03A 3FHGA 1N3AA 3F0ZA 1KG5A 4B22A 4EA4A 3FHFA 3OS1A 4E7HA 2H56A 3S6IA 4BDZA 1YQRA 3N5NX 5CHZA 3OYAA 3L2WA 1N39A 4EJZA 4E9EA 4AIAA 4E9HA 1P7MA 3OYEA 4OFAA 5KN8A 1YQLA 4YPHA 1NKUA 1M3HA 3CVTA 4AI5A 1YQMA 4BE0A 2NOZA 5KN9A 3CWSA 4ZTJA 4E7IA 1P59A 2JHNA 5FRMA 1PU7A 3OH6A 3OYCA 2JG6A 4OFEA 5DPKA 3S3OA 1XG7A 1KG3A 3IH7A 1U84A 3OYBA 4BACA 4EJYA 1PVSA 3CWAA 3VW4A 3CW7A 4B21A 4BE2A 1YQKA 4PIIA 1ORNA 1HU0A 3OGDA 1KEAA 2OFIA 5FRNA 2NOFA 3OYDA 3KTUA 2NOBA 3L2UA 3OYMA 3OYHA 1EBMA 4B24A 2NOLA 1MUNA 3D4VA 3L2VA 3I0XA 4DK9A 1NGNA 2NOEA 3CWTA 3OYIA 2JHJA 3L2QA 5AN4A 3KNTA 4B23A 1RRQA 1KG4A 1WEFA 2V75A 2YG9A 3IHOA 3OY9A 3OH9A 1PU6A 3OYFA 4EW4A 2NOHA 5FROA 4AI4A 1MUDA 4YPRA 3L2RA 1KQJA 3OS2A 3OYNA 4BE1A 1DIZA 1ORPA 4E7LA 4YOQA 1N3CA 1WEGA 1FN7A 3R2XC 1LWYA 3OYKA 1MUYA 2I5WA 1XQPA 3N0UA 2NOIA 3G0QA 3F10A 4UOBA 3S3MA 3OS0A 4BDYA 1WEIA 4IKFA 3NNQA 1RRSA 4E7KA 4E9FA 3CWUA
chains in the Genus database with same CATH topology
4UNFA 3FSPA 1VRLA 1MPGA 1KG2A 4HSBA 4E9GA 2YG8A 1LWWA 1KG6A 4EVVA 1KO9A 4OFHA 4EA5A 1M3QA 2XHIA 3I0WA 2ABKA 1LWVA 1KG7A 3CVSA 1XQOA 1PU8A 1LMZA 2OFKA 4EW0A 3FHGA 1N3AA 3F0ZA 1KG5A 4B22A 4EA4A 3FHFA 3S6IA 2H56A 1YQRA 3N5NX 5CHZA 1N39A 4EJZA 4E9EA 4AIAA 4E9HA 1P7MA 4OFAA 5KN8A 1YQLA 4YPHA 1NKUA 1M3HA 3CVTA 4AI5A 1YQMA 2NOZA 5KN9A 3CWSA 1P59A 2JHNA 1PU7A 3OH6A 2JG6A 4OFEA 5DPKA 1XG7A 1KG3A 3IH7A 4EJYA 1PVSA 3CWAA 3CW7A 4B21A 1YQKA 4PIIA 1ORNA 1HU0A 3OGDA 1KEAA 2OFIA 2NOFA 3KTUA 2NOBA 1EBMA 4B24A 2NOLA 1MUNA 3D4VA 3I0XA 4DK9A 2NOEA 1NGNA 3CWTA 2JHJA 5AN4A 3KNTA 4B23A 1RRQA 1KG4A 1WEFA 2YG9A 3IHOA 4EW4A 3OH9A 1PU6A 2NOHA 4AI4A 1MUDA 4YPRA 1KQJA 1DIZA 1ORPA 4YOQA 1N3CA 1WEGA 1FN7A 1LWYA 1MUYA 2I5WA 1XQPA 3N0UA 2NOIA 3G0QA 3F10A 4UOBA 1WEIA 1RRSA 4E9FA 3CWUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4UNF A;  3FSP A;  1VRL A;  1MPG A;  1KG2 A;  4HSB A;  4E9G A;  2YG8 A;  1LWW A;  1KG6 A;  4EVV A;  1KO9 A;  4OFH A;  4EA5 A;  1M3Q A;  2XHI A;  3I0W A;  2ABK A;  1LWV A;  1KG7 A;  3CVS A;  1XQO A;  1PU8 A;  1LMZ A;  2OFK A;  4EW0 A;  3FHG A;  1N3A A;  3F0Z A;  1KG5 A;  4B22 A;  4EA4 A;  3FHF A;  3S6I A;  2H56 A;  1YQR A;  3N5N X;  5CHZ A;  1N39 A;  4EJZ A;  4E9E A;  4AIA A;  4E9H A;  1P7M A;  4OFA A;  5KN8 A;  1YQL A;  4YPH A;  1NKU A;  1M3H A;  3CVT A;  4AI5 A;  1YQM A;  2NOZ A;  5KN9 A;  3CWS A;  1P59 A;  2JHN A;  1PU7 A;  3OH6 A;  2JG6 A;  4OFE A;  5DPK A;  1XG7 A;  1KG3 A;  3IH7 A;  4EJY A;  1PVS A;  3CWA A;  3CW7 A;  4B21 A;  1YQK A;  4PII A;  1ORN A;  1HU0 A;  3OGD A;  1KEA A;  2OFI A;  2NOF A;  3KTU A;  2NOB A;  1EBM A;  4B24 A;  2NOL A;  1MUN A;  3D4V A;  3I0X A;  4DK9 A;  2NOE A;  1NGN A;  3CWT A;  2JHJ A;  5AN4 A;  3KNT A;  4B23 A;  1RRQ A;  1KG4 A;  1WEF A;  2YG9 A;  3IHO A;  4EW4 A;  3OH9 A;  1PU6 A;  2NOH A;  4AI4 A;  1MUD A;  4YPR A;  1KQJ A;  1DIZ A;  1ORP A;  4YOQ A;  1N3C A;  1WEG A;  1FN7 A;  1LWY A;  1MUY A;  2I5W A;  1XQP A;  3N0U A;  2NOI A;  3G0Q A;  3F10 A;  4UOB A;  1WEI A;  1RRS A;  4E9F A;  3CWU A; 
#chains in the Genus database with same CATH topology
 4UNF A;  3LCN A;  3FSP A;  4ZTF A;  1VRL A;  1MPG A;  1KG2 A;  4HSB A;  4E9G A;  2YG8 A;  2JPS A;  1LWW A;  1KG6 A;  4EVV A;  1KO9 A;  4OFH A;  4NZG A;  4EA5 A;  1M3Q A;  2XHI A;  3I0W A;  4E7J A;  3OYG A;  2W04 A;  2ABK A;  1LWV A;  3S3N A;  1KG7 A;  3CVS A;  3OYL A;  1XQO A;  1PU8 A;  3OYJ A;  1LMZ A;  2OFK A;  4EW0 A;  2W03 A;  3FHG A;  1N3A A;  3F0Z A;  1KG5 A;  4B22 A;  4EA4 A;  3FHF A;  3OS1 A;  4E7H A;  2H56 A;  3S6I A;  4BDZ A;  1YQR A;  3N5N X;  5CHZ A;  3OYA A;  3L2W A;  1N39 A;  4EJZ A;  4E9E A;  4AIA A;  4E9H A;  1P7M A;  3OYE A;  4OFA A;  5KN8 A;  1YQL A;  4YPH A;  1NKU A;  1M3H A;  3CVT A;  4AI5 A;  1YQM A;  4BE0 A;  2NOZ A;  5KN9 A;  3CWS A;  4ZTJ A;  4E7I A;  1P59 A;  2JHN A;  5FRM A;  1PU7 A;  3OH6 A;  3OYC A;  2JG6 A;  4OFE A;  5DPK A;  3S3O A;  1XG7 A;  1KG3 A;  3IH7 A;  1U84 A;  3OYB A;  4BAC A;  4EJY A;  1PVS A;  3CWA A;  3VW4 A;  3CW7 A;  4B21 A;  4BE2 A;  1YQK A;  4PII A;  1ORN A;  1HU0 A;  3OGD A;  1KEA A;  2OFI A;  5FRN A;  2NOF A;  3OYD A;  3KTU A;  2NOB A;  3L2U A;  3OYM A;  3OYH A;  1EBM A;  4B24 A;  2NOL A;  1MUN A;  3D4V A;  3L2V A;  3I0X A;  4DK9 A;  1NGN A;  2NOE A;  3CWT A;  3OYI A;  2JHJ A;  3L2Q A;  5AN4 A;  3KNT A;  4B23 A;  1RRQ A;  1KG4 A;  1WEF A;  2V75 A;  2YG9 A;  3IHO A;  3OY9 A;  3OH9 A;  1PU6 A;  3OYF A;  4EW4 A;  2NOH A;  5FRO A;  4AI4 A;  1MUD A;  4YPR A;  3L2R A;  1KQJ A;  3OS2 A;  3OYN A;  4BE1 A;  1DIZ A;  1ORP A;  4E7L A;  4YOQ A;  1N3C A;  1WEG A;  1FN7 A;  3R2X C;  1LWY A;  3OYK A;  1MUY A;  2I5W A;  1XQP A;  3N0U A;  2NOI A;  3G0Q A;  3F10 A;  4UOB A;  3S3M A;  3OS0 A;  4BDY A;  1WEI A;  4IKF A;  3NNQ A;  1RRS A;  4E7K A;  4E9F A;  3CWU A; 
#chains in the Genus database with same CATH homology
 4UNF A;  3FSP A;  1VRL A;  1MPG A;  1KG2 A;  4HSB A;  4E9G A;  2YG8 A;  1LWW A;  1KG6 A;  4EVV A;  1KO9 A;  4OFH A;  4EA5 A;  1M3Q A;  2XHI A;  3I0W A;  2ABK A;  1LWV A;  1KG7 A;  3CVS A;  1XQO A;  1PU8 A;  1LMZ A;  2OFK A;  4EW0 A;  3FHG A;  1N3A A;  3F0Z A;  1KG5 A;  4B22 A;  4EA4 A;  3FHF A;  3S6I A;  2H56 A;  1YQR A;  3N5N X;  5CHZ A;  1N39 A;  4EJZ A;  4E9E A;  4AIA A;  4E9H A;  1P7M A;  4OFA A;  5KN8 A;  1YQL A;  4YPH A;  1NKU A;  1M3H A;  3CVT A;  4AI5 A;  1YQM A;  2NOZ A;  5KN9 A;  3CWS A;  1P59 A;  2JHN A;  1PU7 A;  3OH6 A;  2JG6 A;  4OFE A;  5DPK A;  1XG7 A;  1KG3 A;  3IH7 A;  4EJY A;  1PVS A;  3CWA A;  3CW7 A;  4B21 A;  1YQK A;  4PII A;  1ORN A;  1HU0 A;  3OGD A;  1KEA A;  2OFI A;  2NOF A;  3KTU A;  2NOB A;  1EBM A;  4B24 A;  2NOL A;  1MUN A;  3D4V A;  3I0X A;  4DK9 A;  2NOE A;  1NGN A;  3CWT A;  2JHJ A;  5AN4 A;  3KNT A;  4B23 A;  1RRQ A;  1KG4 A;  1WEF A;  2YG9 A;  3IHO A;  4EW4 A;  3OH9 A;  1PU6 A;  2NOH A;  4AI4 A;  1MUD A;  4YPR A;  1KQJ A;  1DIZ A;  1ORP A;  4YOQ A;  1N3C A;  1WEG A;  1FN7 A;  1LWY A;  1MUY A;  2I5W A;  1XQP A;  3N0U A;  2NOI A;  3G0Q A;  3F10 A;  4UOB A;  1WEI A;  1RRS A;  4E9F A;  3CWU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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