4EA4A

Structure of the glycosylase domain of mbd4 bound to 5hmu-containing dna
Total Genus 45
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
45
sequence length
137
structure length
137
Chain Sequence
WTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEAHKLNKYHDWLWENH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/dna
molecule keywords Methyl-CpG-binding domain protein 4
publication title Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.
pubmed doi rcsb
source organism Homo sapiens
total genus 45
structure length 137
sequence length 137
ec nomenclature ec 3.2.2.-:
pdb deposition date 2012-03-22
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4ea4A00
3IH7A 3F10A 1LWWA 3OH6A 3CW7A 1XQOA 2ABKA 1NKUA 2NOIA 1EBMA 1LWYA 2NOFA 4E9HA 2H56A 1RRSA 4AIAA 3OGDA 1NGNA 1HU0A 1VRLA 4EVVA 3FHGA 1YQMA 3S6IA 4B23A 2NOZA 1WEGA 1PVSA 3I0WA 4YPRA 1MPGA 4YPHA 1KG6A 4YOQA 2NOBA 3FSPA 4HSBA 3N0UA 3I0XA 4EJZA 3CWSA 1RRQA 1MUDA 1WEIA 1N3CA 1KQJA 3CWTA 3CWAA 4E9GA 4AI5A 1P7MA 1WEFA 4UOBA 4E9EA 4OFAA 1KG2A 3KNTA 2NOLA 4B22A 2XHIA 3D4VA 1M3QA 2YG8A 4OFEA 3CWUA 3KTUA 4E9FA 2JG6A 3OH9A 1YQLA 4EA4A 3F0ZA 1KG3A 1PU6A 1DIZA 2OFKA 5CHZA 3CVSA 4AI4A 1LMZA 4EW0A 2JHNA 1KG7A 3G0QA 3CVTA 5KN8A 1PU8A 1XQPA 1N39A 1ORPA 4UNFA 4PIIA 1FN7A 1P59A 3N5NX 1YQKA 1KG4A 2YG9A 2I5WA 4EA5A 1YQRA 1KEAA 2OFIA 2NOHA 2JHJA 1ORNA 1MUYA 5DPKA 1MUNA 1XG7A 5KN9A 4OFHA 1KO9A 4EW4A 1LWVA 1KG5A 4B24A 1N3AA 4B21A 3IHOA 5AN4A 1M3HA 1PU7A 2NOEA 4DK9A 4EJYA 3FHFA
chains in the Genus database with same CATH superfamily
3IH7A 3F10A 1LWWA 3OH6A 3CW7A 1XQOA 5FRMA 3OYJA 2ABKA 4IKFA 2JPSA 1NKUA 3S3NA 2NOIA 1EBMA 1LWYA 2V75A 2NOFA 3OS1A 4E9HA 3LCNA 2H56A 1RRSA 4AIAA 3OGDA 1NGNA 1HU0A 1VRLA 4EVVA 3FHGA 3R2XC 1YQMA 3L2RA 3VW4A 3S6IA 4B23A 2NOZA 3OYEA 1WEGA 4E7JA 1PVSA 3I0WA 4YPRA 1MPGA 4YPHA 1KG6A 4YOQA 2NOBA 3FSPA 4HSBA 3N0UA 3I0XA 1U84A 4EJZA 3CWSA 1RRQA 3NNQA 1MUDA 1WEIA 1N3CA 1KQJA 3CWTA 3CWAA 4E9GA 3OS2A 2W04A 4AI5A 2W03A 1P7MA 1WEFA 4UOBA 4E9EA 4OFAA 3OYCA 1KG2A 3KNTA 2NOLA 3OYGA 4B22A 3OS0A 2XHIA 3D4VA 4ZTJA 4BDYA 1M3QA 3OYNA 2YG8A 4OFEA 3CWUA 3L2VA 3KTUA 4E9FA 2JG6A 3OH9A 1YQLA 4EA4A 3F0ZA 3OYHA 1KG3A 1PU6A 4E7KA 1DIZA 5FROA 3OYAA 4BACA 4BDZA 2OFKA 3S3MA 5CHZA 3OYDA 3CVSA 4NZGA 4AI4A 1LMZA 3S3OA 3L2WA 3L2UA 4BE2A 4EW0A 2JHNA 1KG7A 3G0QA 3CVTA 5KN8A 4E7HA 1PU8A 1XQPA 1N39A 1ORPA 4UNFA 4BE0A 4PIIA 1FN7A 3L2QA 1P59A 3N5NX 1YQKA 4ZTFA 1KG4A 4E7LA 2YG9A 3OY9A 2I5WA 4EA5A 1YQRA 1KEAA 3OYIA 2OFIA 2JHJA 3OYLA 2NOHA 1ORNA 4BE1A 1MUYA 5FRNA 5DPKA 1MUNA 1XG7A 5KN9A 4OFHA 1KO9A 3OYFA 3OYMA 4EW4A 1LWVA 1KG5A 4B24A 1N3AA 4E7IA 4B21A 3IHOA 5AN4A 3OYBA 1M3HA 1PU7A 2NOEA 4DK9A 4EJYA 3FHFA 3OYKA
chains in the Genus database with same CATH topology
3IH7A 3F10A 1LWWA 3OH6A 3CW7A 1XQOA 2ABKA 1NKUA 2NOIA 1EBMA 1LWYA 2NOFA 4E9HA 2H56A 1RRSA 4AIAA 3OGDA 1NGNA 1HU0A 1VRLA 4EVVA 3FHGA 1YQMA 3S6IA 4B23A 2NOZA 1WEGA 1PVSA 3I0WA 4YPRA 1MPGA 4YPHA 1KG6A 4YOQA 2NOBA 3FSPA 4HSBA 3N0UA 3I0XA 4EJZA 3CWSA 1RRQA 1MUDA 1WEIA 1N3CA 1KQJA 3CWTA 3CWAA 4E9GA 4AI5A 1P7MA 1WEFA 4UOBA 4E9EA 4OFAA 1KG2A 3KNTA 2NOLA 4B22A 2XHIA 3D4VA 1M3QA 2YG8A 4OFEA 3CWUA 3KTUA 4E9FA 2JG6A 3OH9A 1YQLA 4EA4A 3F0ZA 1KG3A 1PU6A 1DIZA 2OFKA 5CHZA 3CVSA 4AI4A 1LMZA 4EW0A 2JHNA 1KG7A 3G0QA 3CVTA 5KN8A 1PU8A 1XQPA 1N39A 1ORPA 4UNFA 4PIIA 1FN7A 1P59A 3N5NX 1YQKA 1KG4A 2YG9A 2I5WA 4EA5A 1YQRA 1KEAA 2OFIA 2NOHA 2JHJA 1ORNA 1MUYA 5DPKA 1MUNA 1XG7A 5KN9A 4OFHA 1KO9A 4EW4A 1LWVA 1KG5A 4B24A 1N3AA 4B21A 3IHOA 5AN4A 1M3HA 1PU7A 2NOEA 4DK9A 4EJYA 3FHFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3IH7 A;  3F10 A;  1LWW A;  3OH6 A;  3CW7 A;  1XQO A;  2ABK A;  1NKU A;  2NOI A;  1EBM A;  1LWY A;  2NOF A;  4E9H A;  2H56 A;  1RRS A;  4AIA A;  3OGD A;  1NGN A;  1HU0 A;  1VRL A;  4EVV A;  3FHG A;  1YQM A;  3S6I A;  4B23 A;  2NOZ A;  1WEG A;  1PVS A;  3I0W A;  4YPR A;  1MPG A;  4YPH A;  1KG6 A;  4YOQ A;  2NOB A;  3FSP A;  4HSB A;  3N0U A;  3I0X A;  4EJZ A;  3CWS A;  1RRQ A;  1MUD A;  1WEI A;  1N3C A;  1KQJ A;  3CWT A;  3CWA A;  4E9G A;  4AI5 A;  1P7M A;  1WEF A;  4UOB A;  4E9E A;  4OFA A;  1KG2 A;  3KNT A;  2NOL A;  4B22 A;  2XHI A;  3D4V A;  1M3Q A;  2YG8 A;  4OFE A;  3CWU A;  3KTU A;  4E9F A;  2JG6 A;  3OH9 A;  1YQL A;  4EA4 A;  3F0Z A;  1KG3 A;  1PU6 A;  1DIZ A;  2OFK A;  5CHZ A;  3CVS A;  4AI4 A;  1LMZ A;  4EW0 A;  2JHN A;  1KG7 A;  3G0Q A;  3CVT A;  5KN8 A;  1PU8 A;  1XQP A;  1N39 A;  1ORP A;  4UNF A;  4PII A;  1FN7 A;  1P59 A;  3N5N X;  1YQK A;  1KG4 A;  2YG9 A;  2I5W A;  4EA5 A;  1YQR A;  1KEA A;  2OFI A;  2NOH A;  2JHJ A;  1ORN A;  1MUY A;  5DPK A;  1MUN A;  1XG7 A;  5KN9 A;  4OFH A;  1KO9 A;  4EW4 A;  1LWV A;  1KG5 A;  4B24 A;  1N3A A;  4B21 A;  3IHO A;  5AN4 A;  1M3H A;  1PU7 A;  2NOE A;  4DK9 A;  4EJY A;  3FHF A; 
#chains in the Genus database with same CATH topology
 3IH7 A;  3F10 A;  1LWW A;  3OH6 A;  3CW7 A;  1XQO A;  5FRM A;  3OYJ A;  2ABK A;  4IKF A;  2JPS A;  1NKU A;  3S3N A;  2NOI A;  1EBM A;  1LWY A;  2V75 A;  2NOF A;  3OS1 A;  4E9H A;  3LCN A;  2H56 A;  1RRS A;  4AIA A;  3OGD A;  1NGN A;  1HU0 A;  1VRL A;  4EVV A;  3FHG A;  3R2X C;  1YQM A;  3L2R A;  3VW4 A;  3S6I A;  4B23 A;  2NOZ A;  3OYE A;  1WEG A;  4E7J A;  1PVS A;  3I0W A;  4YPR A;  1MPG A;  4YPH A;  1KG6 A;  4YOQ A;  2NOB A;  3FSP A;  4HSB A;  3N0U A;  3I0X A;  1U84 A;  4EJZ A;  3CWS A;  1RRQ A;  3NNQ A;  1MUD A;  1WEI A;  1N3C A;  1KQJ A;  3CWT A;  3CWA A;  4E9G A;  3OS2 A;  2W04 A;  4AI5 A;  2W03 A;  1P7M A;  1WEF A;  4UOB A;  4E9E A;  4OFA A;  3OYC A;  1KG2 A;  3KNT A;  2NOL A;  3OYG A;  4B22 A;  3OS0 A;  2XHI A;  3D4V A;  4ZTJ A;  4BDY A;  1M3Q A;  3OYN A;  2YG8 A;  4OFE A;  3CWU A;  3L2V A;  3KTU A;  4E9F A;  2JG6 A;  3OH9 A;  1YQL A;  4EA4 A;  3F0Z A;  3OYH A;  1KG3 A;  1PU6 A;  4E7K A;  1DIZ A;  5FRO A;  3OYA A;  4BAC A;  4BDZ A;  2OFK A;  3S3M A;  5CHZ A;  3OYD A;  3CVS A;  4NZG A;  4AI4 A;  1LMZ A;  3S3O A;  3L2W A;  3L2U A;  4BE2 A;  4EW0 A;  2JHN A;  1KG7 A;  3G0Q A;  3CVT A;  5KN8 A;  4E7H A;  1PU8 A;  1XQP A;  1N39 A;  1ORP A;  4UNF A;  4BE0 A;  4PII A;  1FN7 A;  3L2Q A;  1P59 A;  3N5N X;  1YQK A;  4ZTF A;  1KG4 A;  4E7L A;  2YG9 A;  3OY9 A;  2I5W A;  4EA5 A;  1YQR A;  1KEA A;  3OYI A;  2OFI A;  2JHJ A;  3OYL A;  2NOH A;  1ORN A;  4BE1 A;  1MUY A;  5FRN A;  5DPK A;  1MUN A;  1XG7 A;  5KN9 A;  4OFH A;  1KO9 A;  3OYF A;  3OYM A;  4EW4 A;  1LWV A;  1KG5 A;  4B24 A;  1N3A A;  4E7I A;  4B21 A;  3IHO A;  5AN4 A;  3OYB A;  1M3H A;  1PU7 A;  2NOE A;  4DK9 A;  4EJY A;  3FHF A;  3OYK A; 
#chains in the Genus database with same CATH homology
 3IH7 A;  3F10 A;  1LWW A;  3OH6 A;  3CW7 A;  1XQO A;  2ABK A;  1NKU A;  2NOI A;  1EBM A;  1LWY A;  2NOF A;  4E9H A;  2H56 A;  1RRS A;  4AIA A;  3OGD A;  1NGN A;  1HU0 A;  1VRL A;  4EVV A;  3FHG A;  1YQM A;  3S6I A;  4B23 A;  2NOZ A;  1WEG A;  1PVS A;  3I0W A;  4YPR A;  1MPG A;  4YPH A;  1KG6 A;  4YOQ A;  2NOB A;  3FSP A;  4HSB A;  3N0U A;  3I0X A;  4EJZ A;  3CWS A;  1RRQ A;  1MUD A;  1WEI A;  1N3C A;  1KQJ A;  3CWT A;  3CWA A;  4E9G A;  4AI5 A;  1P7M A;  1WEF A;  4UOB A;  4E9E A;  4OFA A;  1KG2 A;  3KNT A;  2NOL A;  4B22 A;  2XHI A;  3D4V A;  1M3Q A;  2YG8 A;  4OFE A;  3CWU A;  3KTU A;  4E9F A;  2JG6 A;  3OH9 A;  1YQL A;  4EA4 A;  3F0Z A;  1KG3 A;  1PU6 A;  1DIZ A;  2OFK A;  5CHZ A;  3CVS A;  4AI4 A;  1LMZ A;  4EW0 A;  2JHN A;  1KG7 A;  3G0Q A;  3CVT A;  5KN8 A;  1PU8 A;  1XQP A;  1N39 A;  1ORP A;  4UNF A;  4PII A;  1FN7 A;  1P59 A;  3N5N X;  1YQK A;  1KG4 A;  2YG9 A;  2I5W A;  4EA5 A;  1YQR A;  1KEA A;  2OFI A;  2NOH A;  2JHJ A;  1ORN A;  1MUY A;  5DPK A;  1MUN A;  1XG7 A;  5KN9 A;  4OFH A;  1KO9 A;  4EW4 A;  1LWV A;  1KG5 A;  4B24 A;  1N3A A;  4B21 A;  3IHO A;  5AN4 A;  1M3H A;  1PU7 A;  2NOE A;  4DK9 A;  4EJY A;  3FHF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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