4EA4A

Structure of the glycosylase domain of mbd4 bound to 5hmu-containing dna
Total Genus 45
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
45
sequence length
137
structure length
137
Chain Sequence
WTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEAHKLNKYHDWLWENH
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Methyl-CpG-binding domain protein 4
publication title Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase/dna
total genus 45
structure length 137
sequence length 137
ec nomenclature ec 3.2.2.-:
pdb deposition date 2012-03-22
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4ea4A00
4EA5A 1VRLA 1PU7A 2NOBA 3CW7A 2JHJA 2NOIA 1LWYA 2JG6A 2I5WA 3N5NX 1P59A 1YQRA 1PVSA 4E9FA 1KG4A 1FN7A 4OFEA 4B21A 1KG2A 3F0ZA 3OH9A 3CVTA 1KG6A 4AIAA 4AI4A 3IH7A 4E9HA 1LWWA 5KN8A 2NOEA 4EJYA 1WEGA 4EW4A 1KQJA 1ORNA 2NOZA 2H56A 3N0UA 4HSBA 1M3HA 5KN9A 2YG8A 3I0XA 4PIIA 3G0QA 1MPGA 1KEAA 1P7MA 2ABKA 1N39A 4EW0A 3S6IA 1NKUA 4YOQA 2NOHA 3FHGA 2NOFA 1XQOA 1YQMA 2OFKA 4UOBA 1LMZA 1KG7A 4YPRA 1PU6A 3I0WA 4B24A 1M3QA 1KG5A 3KNTA 3CWUA 1ORPA 1LWVA 1NGNA 4B23A 5CHZA 4B22A 1MUDA 1PU8A 1YQLA 1RRQA 1KG3A 4OFAA 1KO9A 1XQPA 1N3AA 1DIZA 3CWTA 4AI5A 4E9GA 2JHNA 1YQKA 4EJZA 3D4VA 1MUNA 3KTUA 1WEIA 4YPHA 1XG7A 4OFHA 1WEFA 4DK9A 1N3CA 5AN4A 3OH6A 1MUYA 4EVVA 1RRSA 3CVSA 1EBMA 1HU0A 3FSPA 3CWAA 4E9EA 5DPKA 3FHFA 3OGDA 3CWSA 2NOLA 2YG9A 4EA4A 3F10A 2XHIA 4UNFA 2OFIA 3IHOA
chains in the Genus database with same CATH superfamily
4EA5A 1VRLA 1PU7A 2NOBA 3OYFA 3CW7A 2JHJA 3OYEA 2NOIA 1LWYA 2JG6A 2I5WA 3N5NX 3OS0A 1YQRA 1P59A 3OYDA 1PVSA 4E9FA 1KG4A 3OYIA 1FN7A 4OFEA 4B21A 2W04A 1KG2A 2W03A 3F0ZA 3OH9A 4IKFA 3CVTA 3OYAA 1KG6A 4AIAA 2V75A 1U84A 4AI4A 3IH7A 5FRMA 4E9HA 1LWWA 5KN8A 2NOEA 4EJYA 4E7HA 1WEGA 4EW4A 1KQJA 1ORNA 2NOZA 2H56A 3N0UA 3OYKA 3VW4A 4HSBA 1M3HA 5KN9A 3S3NA 2YG8A 3I0XA 4NZGA 4PIIA 3G0QA 4BACA 1MPGA 1KEAA 1P7MA 2ABKA 4E7KA 4ZTJA 1N39A 4EW0A 3S6IA 1NKUA 4BDYA 4BE0A 3L2VA 2JPSA 4YOQA 2NOHA 3FHGA 2NOFA 4E7LA 1XQOA 1YQMA 2OFKA 4UOBA 4E7JA 1LMZA 3L2UA 3R2XC 1KG7A 4YPRA 1PU6A 3OS2A 3L2WA 3I0WA 4B24A 3OY9A 1M3QA 1KG5A 3KNTA 3CWUA 3OYNA 1ORPA 1LWVA 3OYGA 1NGNA 4B23A 5CHZA 3OYMA 1MUDA 4B22A 1PU8A 1YQLA 1RRQA 5FRNA 5FROA 4BE2A 1KG3A 4OFAA 3OYLA 4BE1A 1KO9A 3L2RA 1XQPA 1N3AA 1DIZA 3CWTA 4AI5A 4E9GA 2JHNA 1YQKA 4EJZA 3OS1A 3D4VA 1MUNA 3OYJA 3KTUA 1WEIA 4YPHA 1XG7A 3OYBA 3S3MA 4ZTFA 4E7IA 4OFHA 1WEFA 4DK9A 1N3CA 5AN4A 3OH6A 3L2QA 1MUYA 4EVVA 1RRSA 3CVSA 1EBMA 1HU0A 3FSPA 3CWAA 4E9EA 5DPKA 3FHFA 3OGDA 3CWSA 4BDZA 2YG9A 4EA4A 2NOLA 3F10A 3OYCA 3NNQA 2XHIA 4UNFA 3OYHA 3LCNA 2OFIA 3IHOA 3S3OA
chains in the Genus database with same CATH topology
4EA5A 1VRLA 1PU7A 2NOBA 3CW7A 2JHJA 2NOIA 1LWYA 2JG6A 2I5WA 3N5NX 1P59A 1YQRA 1PVSA 4E9FA 1KG4A 1FN7A 4OFEA 4B21A 1KG2A 3F0ZA 3OH9A 3CVTA 1KG6A 4AIAA 4AI4A 3IH7A 4E9HA 1LWWA 5KN8A 2NOEA 4EJYA 1WEGA 4EW4A 1KQJA 1ORNA 2NOZA 2H56A 3N0UA 4HSBA 1M3HA 5KN9A 2YG8A 3I0XA 4PIIA 3G0QA 1MPGA 1KEAA 1P7MA 2ABKA 1N39A 4EW0A 3S6IA 1NKUA 4YOQA 2NOHA 3FHGA 2NOFA 1XQOA 1YQMA 2OFKA 4UOBA 1LMZA 1KG7A 4YPRA 1PU6A 3I0WA 4B24A 1M3QA 1KG5A 3KNTA 3CWUA 1ORPA 1LWVA 1NGNA 4B23A 5CHZA 4B22A 1MUDA 1PU8A 1YQLA 1RRQA 1KG3A 4OFAA 1KO9A 1XQPA 1N3AA 1DIZA 3CWTA 4AI5A 4E9GA 2JHNA 1YQKA 4EJZA 3D4VA 1MUNA 3KTUA 1WEIA 4YPHA 1XG7A 4OFHA 1WEFA 4DK9A 1N3CA 5AN4A 3OH6A 1MUYA 4EVVA 1RRSA 3CVSA 1EBMA 1HU0A 3FSPA 3CWAA 4E9EA 5DPKA 3FHFA 3OGDA 3CWSA 2NOLA 2YG9A 4EA4A 3F10A 2XHIA 4UNFA 2OFIA 3IHOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4EA5 A;  1VRL A;  1PU7 A;  2NOB A;  3CW7 A;  2JHJ A;  2NOI A;  1LWY A;  2JG6 A;  2I5W A;  3N5N X;  1P59 A;  1YQR A;  1PVS A;  4E9F A;  1KG4 A;  1FN7 A;  4OFE A;  4B21 A;  1KG2 A;  3F0Z A;  3OH9 A;  3CVT A;  1KG6 A;  4AIA A;  4AI4 A;  3IH7 A;  4E9H A;  1LWW A;  5KN8 A;  2NOE A;  4EJY A;  1WEG A;  4EW4 A;  1KQJ A;  1ORN A;  2NOZ A;  2H56 A;  3N0U A;  4HSB A;  1M3H A;  5KN9 A;  2YG8 A;  3I0X A;  4PII A;  3G0Q A;  1MPG A;  1KEA A;  1P7M A;  2ABK A;  1N39 A;  4EW0 A;  3S6I A;  1NKU A;  4YOQ A;  2NOH A;  3FHG A;  2NOF A;  1XQO A;  1YQM A;  2OFK A;  4UOB A;  1LMZ A;  1KG7 A;  4YPR A;  1PU6 A;  3I0W A;  4B24 A;  1M3Q A;  1KG5 A;  3KNT A;  3CWU A;  1ORP A;  1LWV A;  1NGN A;  4B23 A;  5CHZ A;  4B22 A;  1MUD A;  1PU8 A;  1YQL A;  1RRQ A;  1KG3 A;  4OFA A;  1KO9 A;  1XQP A;  1N3A A;  1DIZ A;  3CWT A;  4AI5 A;  4E9G A;  2JHN A;  1YQK A;  4EJZ A;  3D4V A;  1MUN A;  3KTU A;  1WEI A;  4YPH A;  1XG7 A;  4OFH A;  1WEF A;  4DK9 A;  1N3C A;  5AN4 A;  3OH6 A;  1MUY A;  4EVV A;  1RRS A;  3CVS A;  1EBM A;  1HU0 A;  3FSP A;  3CWA A;  4E9E A;  5DPK A;  3FHF A;  3OGD A;  3CWS A;  2NOL A;  2YG9 A;  4EA4 A;  3F10 A;  2XHI A;  4UNF A;  2OFI A;  3IHO A; 
#chains in the Genus database with same CATH topology
 4EA5 A;  1VRL A;  1PU7 A;  2NOB A;  3OYF A;  3CW7 A;  2JHJ A;  3OYE A;  2NOI A;  1LWY A;  2JG6 A;  2I5W A;  3N5N X;  3OS0 A;  1YQR A;  1P59 A;  3OYD A;  1PVS A;  4E9F A;  1KG4 A;  3OYI A;  1FN7 A;  4OFE A;  4B21 A;  2W04 A;  1KG2 A;  2W03 A;  3F0Z A;  3OH9 A;  4IKF A;  3CVT A;  3OYA A;  1KG6 A;  4AIA A;  2V75 A;  1U84 A;  4AI4 A;  3IH7 A;  5FRM A;  4E9H A;  1LWW A;  5KN8 A;  2NOE A;  4EJY A;  4E7H A;  1WEG A;  4EW4 A;  1KQJ A;  1ORN A;  2NOZ A;  2H56 A;  3N0U A;  3OYK A;  3VW4 A;  4HSB A;  1M3H A;  5KN9 A;  3S3N A;  2YG8 A;  3I0X A;  4NZG A;  4PII A;  3G0Q A;  4BAC A;  1MPG A;  1KEA A;  1P7M A;  2ABK A;  4E7K A;  4ZTJ A;  1N39 A;  4EW0 A;  3S6I A;  1NKU A;  4BDY A;  4BE0 A;  3L2V A;  2JPS A;  4YOQ A;  2NOH A;  3FHG A;  2NOF A;  4E7L A;  1XQO A;  1YQM A;  2OFK A;  4UOB A;  4E7J A;  1LMZ A;  3L2U A;  3R2X C;  1KG7 A;  4YPR A;  1PU6 A;  3OS2 A;  3L2W A;  3I0W A;  4B24 A;  3OY9 A;  1M3Q A;  1KG5 A;  3KNT A;  3CWU A;  3OYN A;  1ORP A;  1LWV A;  3OYG A;  1NGN A;  4B23 A;  5CHZ A;  3OYM A;  1MUD A;  4B22 A;  1PU8 A;  1YQL A;  1RRQ A;  5FRN A;  5FRO A;  4BE2 A;  1KG3 A;  4OFA A;  3OYL A;  4BE1 A;  1KO9 A;  3L2R A;  1XQP A;  1N3A A;  1DIZ A;  3CWT A;  4AI5 A;  4E9G A;  2JHN A;  1YQK A;  4EJZ A;  3OS1 A;  3D4V A;  1MUN A;  3OYJ A;  3KTU A;  1WEI A;  4YPH A;  1XG7 A;  3OYB A;  3S3M A;  4ZTF A;  4E7I A;  4OFH A;  1WEF A;  4DK9 A;  1N3C A;  5AN4 A;  3OH6 A;  3L2Q A;  1MUY A;  4EVV A;  1RRS A;  3CVS A;  1EBM A;  1HU0 A;  3FSP A;  3CWA A;  4E9E A;  5DPK A;  3FHF A;  3OGD A;  3CWS A;  4BDZ A;  2YG9 A;  4EA4 A;  2NOL A;  3F10 A;  3OYC A;  3NNQ A;  2XHI A;  4UNF A;  3OYH A;  3LCN A;  2OFI A;  3IHO A;  3S3O A; 
#chains in the Genus database with same CATH homology
 4EA5 A;  1VRL A;  1PU7 A;  2NOB A;  3CW7 A;  2JHJ A;  2NOI A;  1LWY A;  2JG6 A;  2I5W A;  3N5N X;  1P59 A;  1YQR A;  1PVS A;  4E9F A;  1KG4 A;  1FN7 A;  4OFE A;  4B21 A;  1KG2 A;  3F0Z A;  3OH9 A;  3CVT A;  1KG6 A;  4AIA A;  4AI4 A;  3IH7 A;  4E9H A;  1LWW A;  5KN8 A;  2NOE A;  4EJY A;  1WEG A;  4EW4 A;  1KQJ A;  1ORN A;  2NOZ A;  2H56 A;  3N0U A;  4HSB A;  1M3H A;  5KN9 A;  2YG8 A;  3I0X A;  4PII A;  3G0Q A;  1MPG A;  1KEA A;  1P7M A;  2ABK A;  1N39 A;  4EW0 A;  3S6I A;  1NKU A;  4YOQ A;  2NOH A;  3FHG A;  2NOF A;  1XQO A;  1YQM A;  2OFK A;  4UOB A;  1LMZ A;  1KG7 A;  4YPR A;  1PU6 A;  3I0W A;  4B24 A;  1M3Q A;  1KG5 A;  3KNT A;  3CWU A;  1ORP A;  1LWV A;  1NGN A;  4B23 A;  5CHZ A;  4B22 A;  1MUD A;  1PU8 A;  1YQL A;  1RRQ A;  1KG3 A;  4OFA A;  1KO9 A;  1XQP A;  1N3A A;  1DIZ A;  3CWT A;  4AI5 A;  4E9G A;  2JHN A;  1YQK A;  4EJZ A;  3D4V A;  1MUN A;  3KTU A;  1WEI A;  4YPH A;  1XG7 A;  4OFH A;  1WEF A;  4DK9 A;  1N3C A;  5AN4 A;  3OH6 A;  1MUY A;  4EVV A;  1RRS A;  3CVS A;  1EBM A;  1HU0 A;  3FSP A;  3CWA A;  4E9E A;  5DPK A;  3FHF A;  3OGD A;  3CWS A;  2NOL A;  2YG9 A;  4EA4 A;  3F10 A;  2XHI A;  4UNF A;  2OFI A;  3IHO A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...