4EA4A

Structure of the glycosylase domain of mbd4 bound to 5hmu-containing dna
Total Genus 45
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
45
sequence length
137
structure length
137
Chain Sequence
WTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEAHKLNKYHDWLWENH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Methyl-CpG-binding domain protein 4
publication title Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase/dna
total genus 45
structure length 137
sequence length 137
ec nomenclature ec 3.2.2.-:
pdb deposition date 2012-03-22
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4ea4A00
3OH9A 4EJYA 2YG9A 3CVSA 4YPRA 2JHJA 3CW7A 3CWSA 2I5WA 1NGNA 1NKUA 4YOQA 1RRSA 1YQKA 1MUYA 3N5NX 1M3HA 4B21A 4E9FA 1KG4A 4EW4A 3IH7A 2NOFA 1WEIA 4AI4A 4B24A 1HU0A 1YQLA 1PVSA 1DIZA 2NOBA 5CHZA 4EW0A 4DK9A 2H56A 4OFAA 3KTUA 1PU8A 1M3QA 1RRQA 1P7MA 5AN4A 4OFEA 1KG5A 4B22A 5KN9A 1VRLA 1MUNA 1YQMA 4HSBA 1PU7A 3G0QA 1N3AA 4B23A 2XHIA 2NOHA 3CWUA 2ABKA 1WEFA 3F10A 3I0WA 5DPKA 2JG6A 3D4VA 2NOLA 1EBMA 1KG3A 1XQPA 1LWWA 2YG8A 1ORNA 1P59A 4UOBA 1LMZA 3OGDA 1ORPA 1MUDA 5KN8A 4E9HA 4OFHA 2JHNA 1KEAA 4AI5A 1KG7A 1WEGA 3IHOA 4E9EA 1N3CA 1FN7A 1MPGA 4UNFA 4E9GA 1PU6A 3CWTA 4EVVA 3CVTA 4YPHA 1KG2A 2NOZA 2NOIA 3F0ZA 3FHGA 4PIIA 4EJZA 2OFKA 1YQRA 3OH6A 1XQOA 3FSPA 1KQJA 3N0UA 4EA4A 2NOEA 2OFIA 1LWYA 1XG7A 3S6IA 1KO9A 3FHFA 4AIAA 3CWAA 1N39A 3KNTA 1LWVA 3I0XA 1KG6A 4EA5A
chains in the Genus database with same CATH superfamily
3LCNA 3OH9A 3L2RA 2YG9A 4EJYA 3CVSA 4BDZA 4YPRA 3OYEA 3OYHA 2JHJA 5FRNA 3R2XC 3CWSA 3CW7A 2I5WA 4BE1A 1NGNA 1NKUA 4YOQA 1RRSA 1U84A 1YQKA 1MUYA 3N5NX 1M3HA 4B21A 4E9FA 1KG4A 4EW4A 3IH7A 5FROA 2NOFA 1WEIA 4AI4A 3OYBA 4B24A 1HU0A 1YQLA 1PVSA 1DIZA 2NOBA 5CHZA 3OYMA 4EW0A 3OYNA 2W03A 4DK9A 2H56A 4OFAA 3KTUA 1PU8A 3OYKA 1M3QA 3S3NA 1RRQA 1P7MA 5AN4A 4OFEA 1KG5A 4B22A 5KN9A 1VRLA 1MUNA 1YQMA 3L2UA 1PU7A 3G0QA 4HSBA 1N3AA 4B23A 3OYFA 3L2QA 2XHIA 2NOHA 3OYDA 3CWUA 2V75A 2ABKA 1WEFA 3OYIA 3F10A 3I0WA 5DPKA 3VW4A 2JG6A 3OYAA 3D4VA 2NOLA 1EBMA 1KG3A 4NZGA 2W04A 1XQPA 3OS0A 1LWWA 2YG8A 1ORNA 3L2VA 1P59A 4UOBA 4E7IA 4ZTJA 1LMZA 3NNQA 3OGDA 1ORPA 1MUDA 5KN8A 4E9HA 4OFHA 2JHNA 1KEAA 4AI5A 4BE0A 1KG7A 3OS2A 3OY9A 4E7JA 1WEGA 3IHOA 4BE2A 3L2WA 4E9EA 4ZTFA 1N3CA 3S3OA 1FN7A 3OS1A 1MPGA 4UNFA 5FRMA 4E9GA 1PU6A 3CWTA 4EVVA 3CVTA 4E7LA 4YPHA 1KG2A 2NOZA 2NOIA 3OYCA 3S3MA 3F0ZA 3FHGA 4PIIA 3OYGA 4EJZA 2OFKA 4E7KA 1YQRA 3OH6A 1XQOA 3OYJA 3FSPA 1KQJA 4E7HA 3N0UA 2JPSA 4BDYA 4EA4A 2NOEA 2OFIA 3OYLA 4BACA 1LWYA 1XG7A 3S6IA 1KO9A 3FHFA 4AIAA 3CWAA 1N39A 3KNTA 1LWVA 3I0XA 1KG6A 4IKFA 4EA5A
chains in the Genus database with same CATH topology
3OH9A 4EJYA 2YG9A 3CVSA 4YPRA 2JHJA 3CW7A 3CWSA 2I5WA 1NGNA 1NKUA 4YOQA 1RRSA 1YQKA 1MUYA 3N5NX 1M3HA 4B21A 4E9FA 1KG4A 4EW4A 3IH7A 2NOFA 1WEIA 4AI4A 4B24A 1HU0A 1YQLA 1PVSA 1DIZA 2NOBA 5CHZA 4EW0A 4DK9A 2H56A 4OFAA 3KTUA 1PU8A 1M3QA 1RRQA 1P7MA 5AN4A 4OFEA 1KG5A 4B22A 5KN9A 1VRLA 1MUNA 1YQMA 4HSBA 1PU7A 3G0QA 1N3AA 4B23A 2XHIA 2NOHA 3CWUA 2ABKA 1WEFA 3F10A 3I0WA 5DPKA 2JG6A 3D4VA 2NOLA 1EBMA 1KG3A 1XQPA 1LWWA 2YG8A 1ORNA 1P59A 4UOBA 1LMZA 3OGDA 1ORPA 1MUDA 5KN8A 4E9HA 4OFHA 2JHNA 1KEAA 4AI5A 1KG7A 1WEGA 3IHOA 4E9EA 1N3CA 1FN7A 1MPGA 4UNFA 4E9GA 1PU6A 3CWTA 4EVVA 3CVTA 4YPHA 1KG2A 2NOZA 2NOIA 3F0ZA 3FHGA 4PIIA 4EJZA 2OFKA 1YQRA 3OH6A 1XQOA 3FSPA 1KQJA 3N0UA 4EA4A 2NOEA 2OFIA 1LWYA 1XG7A 3S6IA 1KO9A 3FHFA 4AIAA 3CWAA 1N39A 3KNTA 1LWVA 3I0XA 1KG6A 4EA5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3OH9 A;  4EJY A;  2YG9 A;  3CVS A;  4YPR A;  2JHJ A;  3CW7 A;  3CWS A;  2I5W A;  1NGN A;  1NKU A;  4YOQ A;  1RRS A;  1YQK A;  1MUY A;  3N5N X;  1M3H A;  4B21 A;  4E9F A;  1KG4 A;  4EW4 A;  3IH7 A;  2NOF A;  1WEI A;  4AI4 A;  4B24 A;  1HU0 A;  1YQL A;  1PVS A;  1DIZ A;  2NOB A;  5CHZ A;  4EW0 A;  4DK9 A;  2H56 A;  4OFA A;  3KTU A;  1PU8 A;  1M3Q A;  1RRQ A;  1P7M A;  5AN4 A;  4OFE A;  1KG5 A;  4B22 A;  5KN9 A;  1VRL A;  1MUN A;  1YQM A;  4HSB A;  1PU7 A;  3G0Q A;  1N3A A;  4B23 A;  2XHI A;  2NOH A;  3CWU A;  2ABK A;  1WEF A;  3F10 A;  3I0W A;  5DPK A;  2JG6 A;  3D4V A;  2NOL A;  1EBM A;  1KG3 A;  1XQP A;  1LWW A;  2YG8 A;  1ORN A;  1P59 A;  4UOB A;  1LMZ A;  3OGD A;  1ORP A;  1MUD A;  5KN8 A;  4E9H A;  4OFH A;  2JHN A;  1KEA A;  4AI5 A;  1KG7 A;  1WEG A;  3IHO A;  4E9E A;  1N3C A;  1FN7 A;  1MPG A;  4UNF A;  4E9G A;  1PU6 A;  3CWT A;  4EVV A;  3CVT A;  4YPH A;  1KG2 A;  2NOZ A;  2NOI A;  3F0Z A;  3FHG A;  4PII A;  4EJZ A;  2OFK A;  1YQR A;  3OH6 A;  1XQO A;  3FSP A;  1KQJ A;  3N0U A;  4EA4 A;  2NOE A;  2OFI A;  1LWY A;  1XG7 A;  3S6I A;  1KO9 A;  3FHF A;  4AIA A;  3CWA A;  1N39 A;  3KNT A;  1LWV A;  3I0X A;  1KG6 A;  4EA5 A; 
#chains in the Genus database with same CATH topology
 3LCN A;  3OH9 A;  3L2R A;  2YG9 A;  4EJY A;  3CVS A;  4BDZ A;  4YPR A;  3OYE A;  3OYH A;  2JHJ A;  5FRN A;  3R2X C;  3CWS A;  3CW7 A;  2I5W A;  4BE1 A;  1NGN A;  1NKU A;  4YOQ A;  1RRS A;  1U84 A;  1YQK A;  1MUY A;  3N5N X;  1M3H A;  4B21 A;  4E9F A;  1KG4 A;  4EW4 A;  3IH7 A;  5FRO A;  2NOF A;  1WEI A;  4AI4 A;  3OYB A;  4B24 A;  1HU0 A;  1YQL A;  1PVS A;  1DIZ A;  2NOB A;  5CHZ A;  3OYM A;  4EW0 A;  3OYN A;  2W03 A;  4DK9 A;  2H56 A;  4OFA A;  3KTU A;  1PU8 A;  3OYK A;  1M3Q A;  3S3N A;  1RRQ A;  1P7M A;  5AN4 A;  4OFE A;  1KG5 A;  4B22 A;  5KN9 A;  1VRL A;  1MUN A;  1YQM A;  3L2U A;  1PU7 A;  3G0Q A;  4HSB A;  1N3A A;  4B23 A;  3OYF A;  3L2Q A;  2XHI A;  2NOH A;  3OYD A;  3CWU A;  2V75 A;  2ABK A;  1WEF A;  3OYI A;  3F10 A;  3I0W A;  5DPK A;  3VW4 A;  2JG6 A;  3OYA A;  3D4V A;  2NOL A;  1EBM A;  1KG3 A;  4NZG A;  2W04 A;  1XQP A;  3OS0 A;  1LWW A;  2YG8 A;  1ORN A;  3L2V A;  1P59 A;  4UOB A;  4E7I A;  4ZTJ A;  1LMZ A;  3NNQ A;  3OGD A;  1ORP A;  1MUD A;  5KN8 A;  4E9H A;  4OFH A;  2JHN A;  1KEA A;  4AI5 A;  4BE0 A;  1KG7 A;  3OS2 A;  3OY9 A;  4E7J A;  1WEG A;  3IHO A;  4BE2 A;  3L2W A;  4E9E A;  4ZTF A;  1N3C A;  3S3O A;  1FN7 A;  3OS1 A;  1MPG A;  4UNF A;  5FRM A;  4E9G A;  1PU6 A;  3CWT A;  4EVV A;  3CVT A;  4E7L A;  4YPH A;  1KG2 A;  2NOZ A;  2NOI A;  3OYC A;  3S3M A;  3F0Z A;  3FHG A;  4PII A;  3OYG A;  4EJZ A;  2OFK A;  4E7K A;  1YQR A;  3OH6 A;  1XQO A;  3OYJ A;  3FSP A;  1KQJ A;  4E7H A;  3N0U A;  2JPS A;  4BDY A;  4EA4 A;  2NOE A;  2OFI A;  3OYL A;  4BAC A;  1LWY A;  1XG7 A;  3S6I A;  1KO9 A;  3FHF A;  4AIA A;  3CWA A;  1N39 A;  3KNT A;  1LWV A;  3I0X A;  1KG6 A;  4IKF A;  4EA5 A; 
#chains in the Genus database with same CATH homology
 3OH9 A;  4EJY A;  2YG9 A;  3CVS A;  4YPR A;  2JHJ A;  3CW7 A;  3CWS A;  2I5W A;  1NGN A;  1NKU A;  4YOQ A;  1RRS A;  1YQK A;  1MUY A;  3N5N X;  1M3H A;  4B21 A;  4E9F A;  1KG4 A;  4EW4 A;  3IH7 A;  2NOF A;  1WEI A;  4AI4 A;  4B24 A;  1HU0 A;  1YQL A;  1PVS A;  1DIZ A;  2NOB A;  5CHZ A;  4EW0 A;  4DK9 A;  2H56 A;  4OFA A;  3KTU A;  1PU8 A;  1M3Q A;  1RRQ A;  1P7M A;  5AN4 A;  4OFE A;  1KG5 A;  4B22 A;  5KN9 A;  1VRL A;  1MUN A;  1YQM A;  4HSB A;  1PU7 A;  3G0Q A;  1N3A A;  4B23 A;  2XHI A;  2NOH A;  3CWU A;  2ABK A;  1WEF A;  3F10 A;  3I0W A;  5DPK A;  2JG6 A;  3D4V A;  2NOL A;  1EBM A;  1KG3 A;  1XQP A;  1LWW A;  2YG8 A;  1ORN A;  1P59 A;  4UOB A;  1LMZ A;  3OGD A;  1ORP A;  1MUD A;  5KN8 A;  4E9H A;  4OFH A;  2JHN A;  1KEA A;  4AI5 A;  1KG7 A;  1WEG A;  3IHO A;  4E9E A;  1N3C A;  1FN7 A;  1MPG A;  4UNF A;  4E9G A;  1PU6 A;  3CWT A;  4EVV A;  3CVT A;  4YPH A;  1KG2 A;  2NOZ A;  2NOI A;  3F0Z A;  3FHG A;  4PII A;  4EJZ A;  2OFK A;  1YQR A;  3OH6 A;  1XQO A;  3FSP A;  1KQJ A;  3N0U A;  4EA4 A;  2NOE A;  2OFI A;  1LWY A;  1XG7 A;  3S6I A;  1KO9 A;  3FHF A;  4AIA A;  3CWA A;  1N39 A;  3KNT A;  1LWV A;  3I0X A;  1KG6 A;  4EA5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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