4OFHA

Structural basis for thymine glycosylase activity on t:o6-methylg mismatch by methyl-cpg binding domain protein 4: implications for roles of arg468 in mismatch recognition and catalysis
Total Genus 51
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
51
sequence length
141
structure length
141
Chain Sequence
WTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPENHKLNKYHDWLWENHEKLS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Methyl-CpG-binding domain protein 4
publication title Structure of MBD4 bound to O6MeG:T mispair DNA
rcsb
source organism Homo sapiens
molecule tags Hydrolase/dna
total genus 51
structure length 141
sequence length 141
ec nomenclature ec 3.2.2.-:
pdb deposition date 2014-01-14
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4ofhA00
1YQRA 4B22A 3S6IA 1PVSA 3KNTA 1KO9A 1ORNA 3F10A 2YG9A 1M3HA 1PU6A 2JHNA 4AIAA 4B21A 4UOBA 4YPRA 4OFHA 1KG3A 3KTUA 3CWAA 4E9EA 4EA5A 3CVSA 1LMZA 3FHFA 3FSPA 4YOQA 1EBMA 1KG2A 2NOIA 3OGDA 1WEGA 1MUYA 2NOBA 1RRSA 2NOFA 5CHZA 4B23A 5KN9A 4HSBA 3CWSA 4DK9A 4E9HA 3CW7A 1MPGA 5AN4A 2OFIA 1WEFA 5DPKA 1MUNA 4UNFA 3CWTA 1P7MA 1YQLA 1KG5A 3I0WA 1KG6A 2JHJA 1XQOA 4AI5A 1M3QA 2JG6A 3F0ZA 5KN8A 1MUDA 4OFEA 4AI4A 4PIIA 3G0QA 1N3CA 4EJZA 3OH6A 2NOHA 3D4VA 4YPHA 2YG8A 4EJYA 1NKUA 4EA4A 3CWUA 1YQMA 1N3AA 1ORPA 3IHOA 1PU8A 2OFKA 1HU0A 1P59A 3N5NX 1VRLA 1NGNA 4OFAA 3I0XA 4E9GA 2ABKA 3N0UA 1KG7A 4EVVA 1N39A 1LWYA 1YQKA 2NOLA 1KEAA 3OH9A 1FN7A 2NOEA 3FHGA 1XQPA 1WEIA 3CVTA 4EW0A 1PU7A 1LWWA 1DIZA 4E9FA 2NOZA 3IH7A 1KQJA 1LWVA 1XG7A 2I5WA 1KG4A 4EW4A 2XHIA 2H56A 4B24A 1RRQA
chains in the Genus database with same CATH superfamily
4BDZA 1YQRA 4B22A 3S6IA 1PVSA 3KNTA 3NNQA 3S3NA 3OYIA 1KO9A 1ORNA 3F10A 2YG9A 1M3HA 5FRMA 1PU6A 4BDYA 2JHNA 4AIAA 4B21A 4UOBA 4YPRA 4OFHA 1KG3A 3KTUA 3CWAA 4E9EA 4EA5A 3CVSA 1LMZA 3FHFA 3OYJA 3FSPA 1U84A 4YOQA 4BE0A 1EBMA 1KG2A 4BACA 3OS1A 2NOIA 3OGDA 3OYMA 3OYCA 4BE2A 1WEGA 1MUYA 4ZTJA 2W03A 2NOBA 1RRSA 3L2RA 2NOFA 5CHZA 4B23A 5KN9A 4HSBA 3CWSA 3OYDA 4DK9A 4E9HA 3CW7A 1MPGA 5AN4A 2OFIA 4BE1A 4IKFA 1WEFA 5DPKA 1MUNA 4UNFA 3CWTA 1P7MA 3OYLA 1YQLA 1KG5A 3I0WA 1KG6A 4E7HA 2JHJA 1XQOA 4E7JA 2V75A 3OY9A 4AI5A 1M3QA 2JG6A 3L2QA 3F0ZA 3OYGA 5KN8A 1MUDA 3L2UA 4OFEA 4AI4A 4PIIA 3G0QA 1N3CA 4EJZA 3OH6A 2NOHA 3D4VA 4YPHA 2YG8A 3LCNA 3S3MA 3R2XC 4EJYA 1NKUA 3OS2A 4EA4A 4E7IA 3CWUA 1YQMA 3OYKA 5FROA 1ORPA 1N3AA 3IHOA 3L2WA 3VW4A 1PU8A 2OFKA 3OYAA 3S3OA 1HU0A 1P59A 3OYFA 3N5NX 1VRLA 1NGNA 4OFAA 3I0XA 4E9GA 2ABKA 3N0UA 3L2VA 4E7LA 1KG7A 4EVVA 1N39A 1LWYA 1YQKA 3OYHA 2NOLA 4ZTFA 1KEAA 2W04A 3OH9A 1FN7A 2NOEA 3OS0A 3FHGA 1XQPA 1WEIA 3CVTA 5FRNA 3OYEA 4EW0A 1PU7A 1LWWA 4E7KA 4NZGA 1DIZA 4E9FA 2NOZA 2JPSA 3OYBA 3IH7A 3OYNA 1KQJA 1LWVA 1XG7A 2I5WA 1KG4A 4EW4A 2XHIA 2H56A 4B24A 1RRQA
chains in the Genus database with same CATH topology
1YQRA 4B22A 3S6IA 1PVSA 3KNTA 1KO9A 1ORNA 3F10A 2YG9A 1M3HA 1PU6A 2JHNA 4AIAA 4B21A 4UOBA 4YPRA 4OFHA 1KG3A 3KTUA 3CWAA 4E9EA 4EA5A 3CVSA 1LMZA 3FHFA 3FSPA 4YOQA 1EBMA 1KG2A 2NOIA 3OGDA 1WEGA 1MUYA 2NOBA 1RRSA 2NOFA 5CHZA 4B23A 5KN9A 4HSBA 3CWSA 4DK9A 4E9HA 3CW7A 1MPGA 5AN4A 2OFIA 1WEFA 5DPKA 1MUNA 4UNFA 3CWTA 1P7MA 1YQLA 1KG5A 3I0WA 1KG6A 2JHJA 1XQOA 4AI5A 1M3QA 2JG6A 3F0ZA 5KN8A 1MUDA 4OFEA 4AI4A 4PIIA 3G0QA 1N3CA 4EJZA 3OH6A 2NOHA 3D4VA 4YPHA 2YG8A 4EJYA 1NKUA 4EA4A 3CWUA 1YQMA 1N3AA 1ORPA 3IHOA 1PU8A 2OFKA 1HU0A 1P59A 3N5NX 1VRLA 1NGNA 4OFAA 3I0XA 4E9GA 2ABKA 3N0UA 1KG7A 4EVVA 1N39A 1LWYA 1YQKA 2NOLA 1KEAA 3OH9A 1FN7A 2NOEA 3FHGA 1XQPA 1WEIA 3CVTA 4EW0A 1PU7A 1LWWA 1DIZA 4E9FA 2NOZA 3IH7A 1KQJA 1LWVA 1XG7A 2I5WA 1KG4A 4EW4A 2XHIA 2H56A 4B24A 1RRQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YQR A;  4B22 A;  3S6I A;  1PVS A;  3KNT A;  1KO9 A;  1ORN A;  3F10 A;  2YG9 A;  1M3H A;  1PU6 A;  2JHN A;  4AIA A;  4B21 A;  4UOB A;  4YPR A;  4OFH A;  1KG3 A;  3KTU A;  3CWA A;  4E9E A;  4EA5 A;  3CVS A;  1LMZ A;  3FHF A;  3FSP A;  4YOQ A;  1EBM A;  1KG2 A;  2NOI A;  3OGD A;  1WEG A;  1MUY A;  2NOB A;  1RRS A;  2NOF A;  5CHZ A;  4B23 A;  5KN9 A;  4HSB A;  3CWS A;  4DK9 A;  4E9H A;  3CW7 A;  1MPG A;  5AN4 A;  2OFI A;  1WEF A;  5DPK A;  1MUN A;  4UNF A;  3CWT A;  1P7M A;  1YQL A;  1KG5 A;  3I0W A;  1KG6 A;  2JHJ A;  1XQO A;  4AI5 A;  1M3Q A;  2JG6 A;  3F0Z A;  5KN8 A;  1MUD A;  4OFE A;  4AI4 A;  4PII A;  3G0Q A;  1N3C A;  4EJZ A;  3OH6 A;  2NOH A;  3D4V A;  4YPH A;  2YG8 A;  4EJY A;  1NKU A;  4EA4 A;  3CWU A;  1YQM A;  1N3A A;  1ORP A;  3IHO A;  1PU8 A;  2OFK A;  1HU0 A;  1P59 A;  3N5N X;  1VRL A;  1NGN A;  4OFA A;  3I0X A;  4E9G A;  2ABK A;  3N0U A;  1KG7 A;  4EVV A;  1N39 A;  1LWY A;  1YQK A;  2NOL A;  1KEA A;  3OH9 A;  1FN7 A;  2NOE A;  3FHG A;  1XQP A;  1WEI A;  3CVT A;  4EW0 A;  1PU7 A;  1LWW A;  1DIZ A;  4E9F A;  2NOZ A;  3IH7 A;  1KQJ A;  1LWV A;  1XG7 A;  2I5W A;  1KG4 A;  4EW4 A;  2XHI A;  2H56 A;  4B24 A;  1RRQ A; 
#chains in the Genus database with same CATH topology
 4BDZ A;  1YQR A;  4B22 A;  3S6I A;  1PVS A;  3KNT A;  3NNQ A;  3S3N A;  3OYI A;  1KO9 A;  1ORN A;  3F10 A;  2YG9 A;  1M3H A;  5FRM A;  1PU6 A;  4BDY A;  2JHN A;  4AIA A;  4B21 A;  4UOB A;  4YPR A;  4OFH A;  1KG3 A;  3KTU A;  3CWA A;  4E9E A;  4EA5 A;  3CVS A;  1LMZ A;  3FHF A;  3OYJ A;  3FSP A;  1U84 A;  4YOQ A;  4BE0 A;  1EBM A;  1KG2 A;  4BAC A;  3OS1 A;  2NOI A;  3OGD A;  3OYM A;  3OYC A;  4BE2 A;  1WEG A;  1MUY A;  4ZTJ A;  2W03 A;  2NOB A;  1RRS A;  3L2R A;  2NOF A;  5CHZ A;  4B23 A;  5KN9 A;  4HSB A;  3CWS A;  3OYD A;  4DK9 A;  4E9H A;  3CW7 A;  1MPG A;  5AN4 A;  2OFI A;  4BE1 A;  4IKF A;  1WEF A;  5DPK A;  1MUN A;  4UNF A;  3CWT A;  1P7M A;  3OYL A;  1YQL A;  1KG5 A;  3I0W A;  1KG6 A;  4E7H A;  2JHJ A;  1XQO A;  4E7J A;  2V75 A;  3OY9 A;  4AI5 A;  1M3Q A;  2JG6 A;  3L2Q A;  3F0Z A;  3OYG A;  5KN8 A;  1MUD A;  3L2U A;  4OFE A;  4AI4 A;  4PII A;  3G0Q A;  1N3C A;  4EJZ A;  3OH6 A;  2NOH A;  3D4V A;  4YPH A;  2YG8 A;  3LCN A;  3S3M A;  3R2X C;  4EJY A;  1NKU A;  3OS2 A;  4EA4 A;  4E7I A;  3CWU A;  1YQM A;  3OYK A;  5FRO A;  1ORP A;  1N3A A;  3IHO A;  3L2W A;  3VW4 A;  1PU8 A;  2OFK A;  3OYA A;  3S3O A;  1HU0 A;  1P59 A;  3OYF A;  3N5N X;  1VRL A;  1NGN A;  4OFA A;  3I0X A;  4E9G A;  2ABK A;  3N0U A;  3L2V A;  4E7L A;  1KG7 A;  4EVV A;  1N39 A;  1LWY A;  1YQK A;  3OYH A;  2NOL A;  4ZTF A;  1KEA A;  2W04 A;  3OH9 A;  1FN7 A;  2NOE A;  3OS0 A;  3FHG A;  1XQP A;  1WEI A;  3CVT A;  5FRN A;  3OYE A;  4EW0 A;  1PU7 A;  1LWW A;  4E7K A;  4NZG A;  1DIZ A;  4E9F A;  2NOZ A;  2JPS A;  3OYB A;  3IH7 A;  3OYN A;  1KQJ A;  1LWV A;  1XG7 A;  2I5W A;  1KG4 A;  4EW4 A;  2XHI A;  2H56 A;  4B24 A;  1RRQ A; 
#chains in the Genus database with same CATH homology
 1YQR A;  4B22 A;  3S6I A;  1PVS A;  3KNT A;  1KO9 A;  1ORN A;  3F10 A;  2YG9 A;  1M3H A;  1PU6 A;  2JHN A;  4AIA A;  4B21 A;  4UOB A;  4YPR A;  4OFH A;  1KG3 A;  3KTU A;  3CWA A;  4E9E A;  4EA5 A;  3CVS A;  1LMZ A;  3FHF A;  3FSP A;  4YOQ A;  1EBM A;  1KG2 A;  2NOI A;  3OGD A;  1WEG A;  1MUY A;  2NOB A;  1RRS A;  2NOF A;  5CHZ A;  4B23 A;  5KN9 A;  4HSB A;  3CWS A;  4DK9 A;  4E9H A;  3CW7 A;  1MPG A;  5AN4 A;  2OFI A;  1WEF A;  5DPK A;  1MUN A;  4UNF A;  3CWT A;  1P7M A;  1YQL A;  1KG5 A;  3I0W A;  1KG6 A;  2JHJ A;  1XQO A;  4AI5 A;  1M3Q A;  2JG6 A;  3F0Z A;  5KN8 A;  1MUD A;  4OFE A;  4AI4 A;  4PII A;  3G0Q A;  1N3C A;  4EJZ A;  3OH6 A;  2NOH A;  3D4V A;  4YPH A;  2YG8 A;  4EJY A;  1NKU A;  4EA4 A;  3CWU A;  1YQM A;  1N3A A;  1ORP A;  3IHO A;  1PU8 A;  2OFK A;  1HU0 A;  1P59 A;  3N5N X;  1VRL A;  1NGN A;  4OFA A;  3I0X A;  4E9G A;  2ABK A;  3N0U A;  1KG7 A;  4EVV A;  1N39 A;  1LWY A;  1YQK A;  2NOL A;  1KEA A;  3OH9 A;  1FN7 A;  2NOE A;  3FHG A;  1XQP A;  1WEI A;  3CVT A;  4EW0 A;  1PU7 A;  1LWW A;  1DIZ A;  4E9F A;  2NOZ A;  3IH7 A;  1KQJ A;  1LWV A;  1XG7 A;  2I5W A;  1KG4 A;  4EW4 A;  2XHI A;  2H56 A;  4B24 A;  1RRQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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