4OFHA

Structural basis for thymine glycosylase activity on t:o6-methylg mismatch by methyl-cpg binding domain protein 4: implications for roles of arg468 in mismatch recognition and catalysis
Total Genus 51
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
51
sequence length
141
structure length
141
Chain Sequence
WTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPENHKLNKYHDWLWENHEKLS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure of MBD4 bound to O6MeG:T mispair DNA
rcsb
molecule tags Hydrolase/dna
source organism Homo sapiens
molecule keywords Methyl-CpG-binding domain protein 4
total genus 51
structure length 141
sequence length 141
ec nomenclature ec 3.2.2.-:
pdb deposition date 2014-01-14
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4ofhA00
2NOZA 4E9EA 3CVSA 1KQJA 3CWAA 3IH7A 1WEIA 1LWWA 4AIAA 5DPKA 3FSPA 4YOQA 1XQOA 2NOLA 2YG9A 3CWTA 1PU7A 1N3AA 3IHOA 2NOIA 4E9HA 3N0UA 3F10A 3CWUA 1LMZA 4EW0A 2NOHA 1N39A 1KG5A 3OGDA 1VRLA 3N5NX 2OFKA 1KG6A 3I0WA 1XQPA 3KNTA 1ORNA 1N3CA 1YQMA 5KN9A 4EJZA 3S6IA 1KO9A 4B24A 1PVSA 4OFHA 4PIIA 4EA5A 4EW4A 5CHZA 1DIZA 3CVTA 4UOBA 1NGNA 3FHGA 1WEFA 2JHJA 2NOBA 4EA4A 1PU6A 4YPRA 5AN4A 1MUYA 2JHNA 4DK9A 1FN7A 4OFAA 1WEGA 1MPGA 3F0ZA 1YQLA 4B22A 3CW7A 2ABKA 2NOEA 4E9GA 3OH6A 1XG7A 1KEAA 4EJYA 2XHIA 3I0XA 1ORPA 1YQKA 1P59A 1KG7A 4UNFA 4B23A 4OFEA 1EBMA 1LWVA 3KTUA 2I5WA 4B21A 1P7MA 1NKUA 1RRQA 4AI5A 3FHFA 1PU8A 1MUNA 3G0QA 1M3HA 2NOFA 1RRSA 1LWYA 3D4VA 1KG3A 1KG2A 4EVVA 3OH9A 1MUDA 2OFIA 1M3QA 4HSBA 2JG6A 2YG8A 3CWSA 4YPHA 5KN8A 2H56A 1KG4A 1HU0A 4AI4A 1YQRA 4E9FA
chains in the Genus database with same CATH superfamily
3OYEA 2NOZA 4E9EA 3CVSA 1KQJA 3VW4A 3OS0A 3CWAA 3IH7A 1WEIA 1LWWA 4AIAA 5DPKA 3FSPA 4YOQA 1XQOA 2NOLA 2YG9A 3CWTA 4EW4A 1PU7A 3OYGA 4ZTFA 1N3AA 3IHOA 2NOIA 4E9HA 5FROA 3N0UA 3OY9A 4IKFA 3F10A 3CWUA 1LMZA 4EW0A 2NOHA 4BDZA 3OYIA 1N39A 1KG5A 3OGDA 4E7LA 1VRLA 3N5NX 2OFKA 3LCNA 4E7JA 1KG6A 3I0WA 1XQPA 3KNTA 4BE0A 1ORNA 5FRNA 4BE1A 4ZTJA 3R2XC 3OYMA 1N3CA 1YQMA 5KN9A 4EJZA 5FRMA 3OYAA 3S6IA 2V75A 1KO9A 4B24A 1PVSA 4OFHA 4PIIA 3OYCA 4BACA 4EA5A 3OYLA 4BE2A 5CHZA 3OYJA 1U84A 4UOBA 1NGNA 3FHGA 1WEFA 2JHJA 3OYFA 1DIZA 2NOBA 4EA4A 1PU6A 4E7IA 4YPRA 5AN4A 1MUYA 2JHNA 4DK9A 3S3OA 1FN7A 4OFAA 1WEGA 1MPGA 3F0ZA 1YQLA 4B22A 3CW7A 3OYHA 2ABKA 4NZGA 3OYBA 4E7KA 2NOEA 3CVTA 4BDYA 4E9GA 3OH6A 1XG7A 1KEAA 4EJYA 2JPSA 2XHIA 3I0XA 3L2WA 1ORPA 1YQKA 1P59A 1KG7A 4UNFA 4B23A 4OFEA 1EBMA 3OS1A 3L2UA 3L2QA 1LWVA 3KTUA 2W03A 2I5WA 4B21A 1P7MA 3OS2A 1NKUA 1RRQA 4AI5A 3OYKA 3FHFA 2W04A 1PU8A 3OYNA 3NNQA 1MUNA 3G0QA 1M3HA 2NOFA 1RRSA 1LWYA 3D4VA 1KG3A 1KG2A 4EVVA 3OH9A 1MUDA 2OFIA 1M3QA 4HSBA 2JG6A 2YG8A 3L2VA 4E7HA 3L2RA 3OYDA 3CWSA 4YPHA 5KN8A 2H56A 1KG4A 3S3MA 3S3NA 4AI4A 1YQRA 1HU0A 4E9FA
chains in the Genus database with same CATH topology
2NOZA 4E9EA 3CVSA 1KQJA 3CWAA 3IH7A 1WEIA 1LWWA 4AIAA 5DPKA 3FSPA 4YOQA 1XQOA 2NOLA 2YG9A 3CWTA 1PU7A 1N3AA 3IHOA 2NOIA 4E9HA 3N0UA 3F10A 3CWUA 1LMZA 4EW0A 2NOHA 1N39A 1KG5A 3OGDA 1VRLA 3N5NX 2OFKA 1KG6A 3I0WA 1XQPA 3KNTA 1ORNA 1N3CA 1YQMA 5KN9A 4EJZA 3S6IA 1KO9A 4B24A 1PVSA 4OFHA 4PIIA 4EA5A 4EW4A 5CHZA 1DIZA 3CVTA 4UOBA 1NGNA 3FHGA 1WEFA 2JHJA 2NOBA 4EA4A 1PU6A 4YPRA 5AN4A 1MUYA 2JHNA 4DK9A 1FN7A 4OFAA 1WEGA 1MPGA 3F0ZA 1YQLA 4B22A 3CW7A 2ABKA 2NOEA 4E9GA 3OH6A 1XG7A 1KEAA 4EJYA 2XHIA 3I0XA 1ORPA 1YQKA 1P59A 1KG7A 4UNFA 4B23A 4OFEA 1EBMA 1LWVA 3KTUA 2I5WA 4B21A 1P7MA 1NKUA 1RRQA 4AI5A 3FHFA 1PU8A 1MUNA 3G0QA 1M3HA 2NOFA 1RRSA 1LWYA 3D4VA 1KG3A 1KG2A 4EVVA 3OH9A 1MUDA 2OFIA 1M3QA 4HSBA 2JG6A 2YG8A 3CWSA 4YPHA 5KN8A 2H56A 1KG4A 1HU0A 4AI4A 1YQRA 4E9FA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2NOZ A;  4E9E A;  3CVS A;  1KQJ A;  3CWA A;  3IH7 A;  1WEI A;  1LWW A;  4AIA A;  5DPK A;  3FSP A;  4YOQ A;  1XQO A;  2NOL A;  2YG9 A;  3CWT A;  1PU7 A;  1N3A A;  3IHO A;  2NOI A;  4E9H A;  3N0U A;  3F10 A;  3CWU A;  1LMZ A;  4EW0 A;  2NOH A;  1N39 A;  1KG5 A;  3OGD A;  1VRL A;  3N5N X;  2OFK A;  1KG6 A;  3I0W A;  1XQP A;  3KNT A;  1ORN A;  1N3C A;  1YQM A;  5KN9 A;  4EJZ A;  3S6I A;  1KO9 A;  4B24 A;  1PVS A;  4OFH A;  4PII A;  4EA5 A;  4EW4 A;  5CHZ A;  1DIZ A;  3CVT A;  4UOB A;  1NGN A;  3FHG A;  1WEF A;  2JHJ A;  2NOB A;  4EA4 A;  1PU6 A;  4YPR A;  5AN4 A;  1MUY A;  2JHN A;  4DK9 A;  1FN7 A;  4OFA A;  1WEG A;  1MPG A;  3F0Z A;  1YQL A;  4B22 A;  3CW7 A;  2ABK A;  2NOE A;  4E9G A;  3OH6 A;  1XG7 A;  1KEA A;  4EJY A;  2XHI A;  3I0X A;  1ORP A;  1YQK A;  1P59 A;  1KG7 A;  4UNF A;  4B23 A;  4OFE A;  1EBM A;  1LWV A;  3KTU A;  2I5W A;  4B21 A;  1P7M A;  1NKU A;  1RRQ A;  4AI5 A;  3FHF A;  1PU8 A;  1MUN A;  3G0Q A;  1M3H A;  2NOF A;  1RRS A;  1LWY A;  3D4V A;  1KG3 A;  1KG2 A;  4EVV A;  3OH9 A;  1MUD A;  2OFI A;  1M3Q A;  4HSB A;  2JG6 A;  2YG8 A;  3CWS A;  4YPH A;  5KN8 A;  2H56 A;  1KG4 A;  1HU0 A;  4AI4 A;  1YQR A;  4E9F A; 
#chains in the Genus database with same CATH topology
 3OYE A;  2NOZ A;  4E9E A;  3CVS A;  1KQJ A;  3VW4 A;  3OS0 A;  3CWA A;  3IH7 A;  1WEI A;  1LWW A;  4AIA A;  5DPK A;  3FSP A;  4YOQ A;  1XQO A;  2NOL A;  2YG9 A;  3CWT A;  4EW4 A;  1PU7 A;  3OYG A;  4ZTF A;  1N3A A;  3IHO A;  2NOI A;  4E9H A;  5FRO A;  3N0U A;  3OY9 A;  4IKF A;  3F10 A;  3CWU A;  1LMZ A;  4EW0 A;  2NOH A;  4BDZ A;  3OYI A;  1N39 A;  1KG5 A;  3OGD A;  4E7L A;  1VRL A;  3N5N X;  2OFK A;  3LCN A;  4E7J A;  1KG6 A;  3I0W A;  1XQP A;  3KNT A;  4BE0 A;  1ORN A;  5FRN A;  4BE1 A;  4ZTJ A;  3R2X C;  3OYM A;  1N3C A;  1YQM A;  5KN9 A;  4EJZ A;  5FRM A;  3OYA A;  3S6I A;  2V75 A;  1KO9 A;  4B24 A;  1PVS A;  4OFH A;  4PII A;  3OYC A;  4BAC A;  4EA5 A;  3OYL A;  4BE2 A;  5CHZ A;  3OYJ A;  1U84 A;  4UOB A;  1NGN A;  3FHG A;  1WEF A;  2JHJ A;  3OYF A;  1DIZ A;  2NOB A;  4EA4 A;  1PU6 A;  4E7I A;  4YPR A;  5AN4 A;  1MUY A;  2JHN A;  4DK9 A;  3S3O A;  1FN7 A;  4OFA A;  1WEG A;  1MPG A;  3F0Z A;  1YQL A;  4B22 A;  3CW7 A;  3OYH A;  2ABK A;  4NZG A;  3OYB A;  4E7K A;  2NOE A;  3CVT A;  4BDY A;  4E9G A;  3OH6 A;  1XG7 A;  1KEA A;  4EJY A;  2JPS A;  2XHI A;  3I0X A;  3L2W A;  1ORP A;  1YQK A;  1P59 A;  1KG7 A;  4UNF A;  4B23 A;  4OFE A;  1EBM A;  3OS1 A;  3L2U A;  3L2Q A;  1LWV A;  3KTU A;  2W03 A;  2I5W A;  4B21 A;  1P7M A;  3OS2 A;  1NKU A;  1RRQ A;  4AI5 A;  3OYK A;  3FHF A;  2W04 A;  1PU8 A;  3OYN A;  3NNQ A;  1MUN A;  3G0Q A;  1M3H A;  2NOF A;  1RRS A;  1LWY A;  3D4V A;  1KG3 A;  1KG2 A;  4EVV A;  3OH9 A;  1MUD A;  2OFI A;  1M3Q A;  4HSB A;  2JG6 A;  2YG8 A;  3L2V A;  4E7H A;  3L2R A;  3OYD A;  3CWS A;  4YPH A;  5KN8 A;  2H56 A;  1KG4 A;  3S3M A;  3S3N A;  4AI4 A;  1YQR A;  1HU0 A;  4E9F A; 
#chains in the Genus database with same CATH homology
 2NOZ A;  4E9E A;  3CVS A;  1KQJ A;  3CWA A;  3IH7 A;  1WEI A;  1LWW A;  4AIA A;  5DPK A;  3FSP A;  4YOQ A;  1XQO A;  2NOL A;  2YG9 A;  3CWT A;  1PU7 A;  1N3A A;  3IHO A;  2NOI A;  4E9H A;  3N0U A;  3F10 A;  3CWU A;  1LMZ A;  4EW0 A;  2NOH A;  1N39 A;  1KG5 A;  3OGD A;  1VRL A;  3N5N X;  2OFK A;  1KG6 A;  3I0W A;  1XQP A;  3KNT A;  1ORN A;  1N3C A;  1YQM A;  5KN9 A;  4EJZ A;  3S6I A;  1KO9 A;  4B24 A;  1PVS A;  4OFH A;  4PII A;  4EA5 A;  4EW4 A;  5CHZ A;  1DIZ A;  3CVT A;  4UOB A;  1NGN A;  3FHG A;  1WEF A;  2JHJ A;  2NOB A;  4EA4 A;  1PU6 A;  4YPR A;  5AN4 A;  1MUY A;  2JHN A;  4DK9 A;  1FN7 A;  4OFA A;  1WEG A;  1MPG A;  3F0Z A;  1YQL A;  4B22 A;  3CW7 A;  2ABK A;  2NOE A;  4E9G A;  3OH6 A;  1XG7 A;  1KEA A;  4EJY A;  2XHI A;  3I0X A;  1ORP A;  1YQK A;  1P59 A;  1KG7 A;  4UNF A;  4B23 A;  4OFE A;  1EBM A;  1LWV A;  3KTU A;  2I5W A;  4B21 A;  1P7M A;  1NKU A;  1RRQ A;  4AI5 A;  3FHF A;  1PU8 A;  1MUN A;  3G0Q A;  1M3H A;  2NOF A;  1RRS A;  1LWY A;  3D4V A;  1KG3 A;  1KG2 A;  4EVV A;  3OH9 A;  1MUD A;  2OFI A;  1M3Q A;  4HSB A;  2JG6 A;  2YG8 A;  3CWS A;  4YPH A;  5KN8 A;  2H56 A;  1KG4 A;  1HU0 A;  4AI4 A;  1YQR A;  4E9F A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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