4OFHA

Structural basis for thymine glycosylase activity on t:o6-methylg mismatch by methyl-cpg binding domain protein 4: implications for roles of arg468 in mismatch recognition and catalysis
Total Genus 51
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
51
sequence length
141
structure length
141
Chain Sequence
WTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPENHKLNKYHDWLWENHEKLS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Methyl-CpG-binding domain protein 4
publication title Structure of MBD4 bound to O6MeG:T mispair DNA
rcsb
source organism Homo sapiens
molecule tags Hydrolase/dna
total genus 51
structure length 141
sequence length 141
ec nomenclature ec 3.2.2.-:
pdb deposition date 2014-01-14
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4ofhA00
1LWVA 4EA4A 1YQKA 1PU8A 3FHGA 4EVVA 1N3AA 3F0ZA 4AI4A 4DK9A 3OH9A 5KN9A 3CWAA 4OFAA 1N3CA 2NOZA 3N5NX 1M3QA 4YOQA 5DPKA 2NOEA 1NGNA 5KN8A 3OH6A 3CWUA 1KG2A 4E9GA 1WEIA 1YQMA 4UOBA 1ORNA 3I0XA 1XG7A 4B22A 4EA5A 1KQJA 1P59A 4OFEA 3IH7A 1MUYA 4E9HA 1HU0A 4B24A 3CW7A 1MUDA 1WEGA 2NOFA 3FSPA 1FN7A 3G0QA 1MPGA 3S6IA 3IHOA 4YPRA 3N0UA 5AN4A 4PIIA 3KTUA 2NOBA 1RRSA 2JHJA 1EBMA 2YG9A 2H56A 4EW4A 1WEFA 1NKUA 1KG4A 3KNTA 1ORPA 4UNFA 1P7MA 2JHNA 1KG5A 1MUNA 2ABKA 3CVTA 3OGDA 1LWYA 3CVSA 2NOIA 2OFIA 1KG7A 1KEAA 1LMZA 5CHZA 1VRLA 3FHFA 4HSBA 4E9FA 1XQOA 2NOLA 2YG8A 4AIAA 2NOHA 2OFKA 2JG6A 1N39A 4OFHA 1LWWA 1YQLA 4EW0A 2I5WA 1XQPA 3I0WA 1M3HA 1YQRA 4EJYA 4B21A 1KG3A 4YPHA 3CWSA 1KO9A 2XHIA 4EJZA 1PU7A 3F10A 1KG6A 3CWTA 1RRQA 4B23A 1DIZA 1PU6A 4AI5A 1PVSA 4E9EA 3D4VA
chains in the Genus database with same CATH superfamily
1LWVA 3S3MA 4EA4A 1YQKA 1PU8A 3FHGA 3OYNA 4EVVA 4ZTFA 1N3AA 3F0ZA 4AI4A 4DK9A 3OH9A 4BACA 5KN9A 3OYHA 3CWAA 4OFAA 1N3CA 2NOZA 3N5NX 1M3QA 4YOQA 3L2WA 3S3OA 5DPKA 2V75A 3S3NA 2NOEA 3NNQA 1NGNA 5KN8A 3OH6A 4ZTJA 3CWUA 1KG2A 4E9GA 4E7LA 1WEIA 3OY9A 4UOBA 3OYMA 1YQMA 1ORNA 3I0XA 1XG7A 3OS1A 3L2QA 4B22A 4EA5A 1KQJA 5FRNA 1P59A 2W04A 4OFEA 3IH7A 1MUYA 4E9HA 1HU0A 4B24A 3CW7A 1MUDA 1WEGA 3R2XC 2NOFA 3FSPA 4BE2A 1FN7A 3G0QA 1MPGA 3S6IA 3OYBA 3IHOA 4YPRA 3N0UA 5AN4A 4PIIA 3OYKA 3KTUA 2NOBA 3OYIA 1RRSA 2JHJA 2W03A 3VW4A 1EBMA 2YG9A 2H56A 4EW4A 1WEFA 2JPSA 1NKUA 1KG4A 3KNTA 1ORPA 4UNFA 1P7MA 2JHNA 1KG5A 1MUNA 2ABKA 3OYLA 3OS0A 3CVTA 3OGDA 1U84A 3CVSA 1LWYA 5FROA 4E7IA 2NOIA 2OFIA 1KG7A 1KEAA 1LMZA 5CHZA 3OYAA 1VRLA 3FHFA 4HSBA 4E9FA 1XQOA 2NOLA 2YG8A 4AIAA 4BDYA 2NOHA 3L2UA 2OFKA 3OYFA 2JG6A 1N39A 4OFHA 3OS2A 1LWWA 3OYGA 1YQLA 3OYEA 3L2VA 4EW0A 2I5WA 1XQPA 4BE0A 3I0WA 1M3HA 4E7HA 1YQRA 4EJYA 4B21A 1KG3A 4E7KA 4YPHA 3CWSA 1KO9A 4BDZA 3L2RA 2XHIA 4EJZA 1PU7A 4E7JA 3F10A 5FRMA 1KG6A 3OYCA 3CWTA 1RRQA 4B23A 3OYJA 1DIZA 4IKFA 1PU6A 3LCNA 4NZGA 4AI5A 1PVSA 4E9EA 3OYDA 3D4VA 4BE1A
chains in the Genus database with same CATH topology
1LWVA 4EA4A 1YQKA 1PU8A 3FHGA 4EVVA 1N3AA 3F0ZA 4AI4A 4DK9A 3OH9A 5KN9A 3CWAA 4OFAA 1N3CA 2NOZA 3N5NX 1M3QA 4YOQA 5DPKA 2NOEA 1NGNA 5KN8A 3OH6A 3CWUA 1KG2A 4E9GA 1WEIA 1YQMA 4UOBA 1ORNA 3I0XA 1XG7A 4B22A 4EA5A 1KQJA 1P59A 4OFEA 3IH7A 1MUYA 4E9HA 1HU0A 4B24A 3CW7A 1MUDA 1WEGA 2NOFA 3FSPA 1FN7A 3G0QA 1MPGA 3S6IA 3IHOA 4YPRA 3N0UA 5AN4A 4PIIA 3KTUA 2NOBA 1RRSA 2JHJA 1EBMA 2YG9A 2H56A 4EW4A 1WEFA 1NKUA 1KG4A 3KNTA 1ORPA 4UNFA 1P7MA 2JHNA 1KG5A 1MUNA 2ABKA 3CVTA 3OGDA 1LWYA 3CVSA 2NOIA 2OFIA 1KG7A 1KEAA 1LMZA 5CHZA 1VRLA 3FHFA 4HSBA 4E9FA 1XQOA 2NOLA 2YG8A 4AIAA 2NOHA 2OFKA 2JG6A 1N39A 4OFHA 1LWWA 1YQLA 4EW0A 2I5WA 1XQPA 3I0WA 1M3HA 1YQRA 4EJYA 4B21A 1KG3A 4YPHA 3CWSA 1KO9A 2XHIA 4EJZA 1PU7A 3F10A 1KG6A 3CWTA 1RRQA 4B23A 1DIZA 1PU6A 4AI5A 1PVSA 4E9EA 3D4VA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1LWV A;  4EA4 A;  1YQK A;  1PU8 A;  3FHG A;  4EVV A;  1N3A A;  3F0Z A;  4AI4 A;  4DK9 A;  3OH9 A;  5KN9 A;  3CWA A;  4OFA A;  1N3C A;  2NOZ A;  3N5N X;  1M3Q A;  4YOQ A;  5DPK A;  2NOE A;  1NGN A;  5KN8 A;  3OH6 A;  3CWU A;  1KG2 A;  4E9G A;  1WEI A;  1YQM A;  4UOB A;  1ORN A;  3I0X A;  1XG7 A;  4B22 A;  4EA5 A;  1KQJ A;  1P59 A;  4OFE A;  3IH7 A;  1MUY A;  4E9H A;  1HU0 A;  4B24 A;  3CW7 A;  1MUD A;  1WEG A;  2NOF A;  3FSP A;  1FN7 A;  3G0Q A;  1MPG A;  3S6I A;  3IHO A;  4YPR A;  3N0U A;  5AN4 A;  4PII A;  3KTU A;  2NOB A;  1RRS A;  2JHJ A;  1EBM A;  2YG9 A;  2H56 A;  4EW4 A;  1WEF A;  1NKU A;  1KG4 A;  3KNT A;  1ORP A;  4UNF A;  1P7M A;  2JHN A;  1KG5 A;  1MUN A;  2ABK A;  3CVT A;  3OGD A;  1LWY A;  3CVS A;  2NOI A;  2OFI A;  1KG7 A;  1KEA A;  1LMZ A;  5CHZ A;  1VRL A;  3FHF A;  4HSB A;  4E9F A;  1XQO A;  2NOL A;  2YG8 A;  4AIA A;  2NOH A;  2OFK A;  2JG6 A;  1N39 A;  4OFH A;  1LWW A;  1YQL A;  4EW0 A;  2I5W A;  1XQP A;  3I0W A;  1M3H A;  1YQR A;  4EJY A;  4B21 A;  1KG3 A;  4YPH A;  3CWS A;  1KO9 A;  2XHI A;  4EJZ A;  1PU7 A;  3F10 A;  1KG6 A;  3CWT A;  1RRQ A;  4B23 A;  1DIZ A;  1PU6 A;  4AI5 A;  1PVS A;  4E9E A;  3D4V A; 
#chains in the Genus database with same CATH topology
 1LWV A;  3S3M A;  4EA4 A;  1YQK A;  1PU8 A;  3FHG A;  3OYN A;  4EVV A;  4ZTF A;  1N3A A;  3F0Z A;  4AI4 A;  4DK9 A;  3OH9 A;  4BAC A;  5KN9 A;  3OYH A;  3CWA A;  4OFA A;  1N3C A;  2NOZ A;  3N5N X;  1M3Q A;  4YOQ A;  3L2W A;  3S3O A;  5DPK A;  2V75 A;  3S3N A;  2NOE A;  3NNQ A;  1NGN A;  5KN8 A;  3OH6 A;  4ZTJ A;  3CWU A;  1KG2 A;  4E9G A;  4E7L A;  1WEI A;  3OY9 A;  4UOB A;  3OYM A;  1YQM A;  1ORN A;  3I0X A;  1XG7 A;  3OS1 A;  3L2Q A;  4B22 A;  4EA5 A;  1KQJ A;  5FRN A;  1P59 A;  2W04 A;  4OFE A;  3IH7 A;  1MUY A;  4E9H A;  1HU0 A;  4B24 A;  3CW7 A;  1MUD A;  1WEG A;  3R2X C;  2NOF A;  3FSP A;  4BE2 A;  1FN7 A;  3G0Q A;  1MPG A;  3S6I A;  3OYB A;  3IHO A;  4YPR A;  3N0U A;  5AN4 A;  4PII A;  3OYK A;  3KTU A;  2NOB A;  3OYI A;  1RRS A;  2JHJ A;  2W03 A;  3VW4 A;  1EBM A;  2YG9 A;  2H56 A;  4EW4 A;  1WEF A;  2JPS A;  1NKU A;  1KG4 A;  3KNT A;  1ORP A;  4UNF A;  1P7M A;  2JHN A;  1KG5 A;  1MUN A;  2ABK A;  3OYL A;  3OS0 A;  3CVT A;  3OGD A;  1U84 A;  3CVS A;  1LWY A;  5FRO A;  4E7I A;  2NOI A;  2OFI A;  1KG7 A;  1KEA A;  1LMZ A;  5CHZ A;  3OYA A;  1VRL A;  3FHF A;  4HSB A;  4E9F A;  1XQO A;  2NOL A;  2YG8 A;  4AIA A;  4BDY A;  2NOH A;  3L2U A;  2OFK A;  3OYF A;  2JG6 A;  1N39 A;  4OFH A;  3OS2 A;  1LWW A;  3OYG A;  1YQL A;  3OYE A;  3L2V A;  4EW0 A;  2I5W A;  1XQP A;  4BE0 A;  3I0W A;  1M3H A;  4E7H A;  1YQR A;  4EJY A;  4B21 A;  1KG3 A;  4E7K A;  4YPH A;  3CWS A;  1KO9 A;  4BDZ A;  3L2R A;  2XHI A;  4EJZ A;  1PU7 A;  4E7J A;  3F10 A;  5FRM A;  1KG6 A;  3OYC A;  3CWT A;  1RRQ A;  4B23 A;  3OYJ A;  1DIZ A;  4IKF A;  1PU6 A;  3LCN A;  4NZG A;  4AI5 A;  1PVS A;  4E9E A;  3OYD A;  3D4V A;  4BE1 A; 
#chains in the Genus database with same CATH homology
 1LWV A;  4EA4 A;  1YQK A;  1PU8 A;  3FHG A;  4EVV A;  1N3A A;  3F0Z A;  4AI4 A;  4DK9 A;  3OH9 A;  5KN9 A;  3CWA A;  4OFA A;  1N3C A;  2NOZ A;  3N5N X;  1M3Q A;  4YOQ A;  5DPK A;  2NOE A;  1NGN A;  5KN8 A;  3OH6 A;  3CWU A;  1KG2 A;  4E9G A;  1WEI A;  1YQM A;  4UOB A;  1ORN A;  3I0X A;  1XG7 A;  4B22 A;  4EA5 A;  1KQJ A;  1P59 A;  4OFE A;  3IH7 A;  1MUY A;  4E9H A;  1HU0 A;  4B24 A;  3CW7 A;  1MUD A;  1WEG A;  2NOF A;  3FSP A;  1FN7 A;  3G0Q A;  1MPG A;  3S6I A;  3IHO A;  4YPR A;  3N0U A;  5AN4 A;  4PII A;  3KTU A;  2NOB A;  1RRS A;  2JHJ A;  1EBM A;  2YG9 A;  2H56 A;  4EW4 A;  1WEF A;  1NKU A;  1KG4 A;  3KNT A;  1ORP A;  4UNF A;  1P7M A;  2JHN A;  1KG5 A;  1MUN A;  2ABK A;  3CVT A;  3OGD A;  1LWY A;  3CVS A;  2NOI A;  2OFI A;  1KG7 A;  1KEA A;  1LMZ A;  5CHZ A;  1VRL A;  3FHF A;  4HSB A;  4E9F A;  1XQO A;  2NOL A;  2YG8 A;  4AIA A;  2NOH A;  2OFK A;  2JG6 A;  1N39 A;  4OFH A;  1LWW A;  1YQL A;  4EW0 A;  2I5W A;  1XQP A;  3I0W A;  1M3H A;  1YQR A;  4EJY A;  4B21 A;  1KG3 A;  4YPH A;  3CWS A;  1KO9 A;  2XHI A;  4EJZ A;  1PU7 A;  3F10 A;  1KG6 A;  3CWT A;  1RRQ A;  4B23 A;  1DIZ A;  1PU6 A;  4AI5 A;  1PVS A;  4E9E A;  3D4V A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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