4EA5A

Structure of the glycoslyase domain of mbd4 bound to a 5hmu containing dna
Total Genus 49
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
136
structure length
136
Chain Sequence
TPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEAHKLNKYHDWLWENH
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Methyl-CpG-binding domain protein 4
publication title Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase/dna
total genus 49
structure length 136
sequence length 136
ec nomenclature ec 3.2.2.-:
pdb deposition date 2012-03-22
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4ea5A00
1LMZA 1XQPA 4OFEA 1RRSA 3N5NX 1N3CA 1WEFA 1PU8A 1KO9A 1WEIA 1KG2A 4YPHA 4E9EA 1VRLA 4EJYA 2XHIA 4EA5A 4OFHA 3CVSA 1P7MA 3F0ZA 3OGDA 1KG3A 4EA4A 5AN4A 3CWSA 3KTUA 1NGNA 3CWUA 4OFAA 1KEAA 1KG6A 1PVSA 3KNTA 2OFKA 2JG6A 4PIIA 3S6IA 4EW4A 1RRQA 2I5WA 1M3HA 1FN7A 3FSPA 4E9GA 4EW0A 3N0UA 1MUDA 2NOLA 1M3QA 1PU6A 4HSBA 1ORPA 1KQJA 3G0QA 2YG9A 4E9FA 1YQRA 2NOBA 1N39A 4AI5A 4UNFA 5KN8A 2NOZA 1KG7A 4B23A 3IH7A 4EVVA 4E9HA 1MPGA 3CW7A 1DIZA 1P59A 2YG8A 4B21A 3I0WA 4B22A 1PU7A 1LWWA 1XG7A 2JHNA 2JHJA 2NOIA 3F10A 1YQMA 5DPKA 1KG5A 4YOQA 5CHZA 4EJZA 4UOBA 1N3AA 3CWTA 1NKUA 2H56A 3D4VA 4B24A 5KN9A 3FHGA 2NOEA 2OFIA 4DK9A 1MUNA 3OH6A 1YQLA 2NOHA 1YQKA 1LWYA 3I0XA 3CVTA 2ABKA 3FHFA 4YPRA 3OH9A 3CWAA 1MUYA 1LWVA 1WEGA 1XQOA 1ORNA 4AIAA 2NOFA 3IHOA 4AI4A 1KG4A 1HU0A 1EBMA
chains in the Genus database with same CATH superfamily
1LMZA 1XQPA 4OFEA 3OYDA 3OYGA 4BE2A 3OY9A 3VW4A 3S3MA 1RRSA 3N5NX 3S3NA 1N3CA 1WEFA 1PU8A 1KO9A 1WEIA 1KG2A 3OYJA 4YPHA 4E9EA 1VRLA 3OYKA 4EJYA 3OYMA 2XHIA 4EA5A 4OFHA 3L2QA 3CVSA 1P7MA 3F0ZA 3R2XC 3OGDA 1KG3A 4EA4A 5AN4A 3CWSA 5FRNA 3KTUA 1NGNA 2W03A 3NNQA 3CWUA 4BE0A 4OFAA 1KEAA 1KG6A 1PVSA 3KNTA 2OFKA 2JG6A 4PIIA 2W04A 3S6IA 4EW4A 4E7JA 1RRQA 2I5WA 1M3HA 1FN7A 3FSPA 4BDZA 4E9GA 3L2WA 3OYBA 3L2UA 4EW0A 3N0UA 3OYIA 1MUDA 2NOLA 1M3QA 1PU6A 4HSBA 1ORPA 1KQJA 4E7IA 3G0QA 2YG9A 4BACA 3OS0A 4E9FA 3OYHA 3OYLA 1YQRA 2NOBA 3OYCA 1N39A 3L2RA 4AI5A 4UNFA 5KN8A 2NOZA 1KG7A 4B23A 3IH7A 4EVVA 4E9HA 1MPGA 3CW7A 1DIZA 1P59A 2YG8A 4B21A 3I0WA 3OYNA 4B22A 1PU7A 1LWWA 1XG7A 2JHNA 4E7LA 1U84A 3OS1A 2JHJA 4ZTJA 2NOIA 3F10A 5FROA 3OYAA 1YQMA 5DPKA 1KG5A 4YOQA 5CHZA 4EJZA 4UOBA 1N3AA 3CWTA 1NKUA 2H56A 4E7HA 4E7KA 3LCNA 3D4VA 4ZTFA 4B24A 5KN9A 3FHGA 2NOEA 2OFIA 3OYEA 4DK9A 4BDYA 1MUNA 3OH6A 1YQLA 2NOHA 1YQKA 1LWYA 3I0XA 3OYFA 3L2VA 3CVTA 2ABKA 4IKFA 3FHFA 4YPRA 3OH9A 4BE1A 3CWAA 1MUYA 1LWVA 1WEGA 4NZGA 3OS2A 1XQOA 2V75A 1ORNA 4AIAA 2NOFA 3S3OA 3IHOA 4AI4A 5FRMA 2JPSA 1KG4A 1HU0A 1EBMA
chains in the Genus database with same CATH topology
1LMZA 1XQPA 4OFEA 1RRSA 3N5NX 1N3CA 1WEFA 1PU8A 1KO9A 1WEIA 1KG2A 4YPHA 4E9EA 1VRLA 4EJYA 2XHIA 4EA5A 4OFHA 3CVSA 1P7MA 3F0ZA 3OGDA 1KG3A 4EA4A 5AN4A 3CWSA 3KTUA 1NGNA 3CWUA 4OFAA 1KEAA 1KG6A 1PVSA 3KNTA 2OFKA 2JG6A 4PIIA 3S6IA 4EW4A 1RRQA 2I5WA 1M3HA 1FN7A 3FSPA 4E9GA 4EW0A 3N0UA 1MUDA 2NOLA 1M3QA 1PU6A 4HSBA 1ORPA 1KQJA 3G0QA 2YG9A 4E9FA 1YQRA 2NOBA 1N39A 4AI5A 4UNFA 5KN8A 2NOZA 1KG7A 4B23A 3IH7A 4EVVA 4E9HA 1MPGA 3CW7A 1DIZA 1P59A 2YG8A 4B21A 3I0WA 4B22A 1PU7A 1LWWA 1XG7A 2JHNA 2JHJA 2NOIA 3F10A 1YQMA 5DPKA 1KG5A 4YOQA 5CHZA 4EJZA 4UOBA 1N3AA 3CWTA 1NKUA 2H56A 3D4VA 4B24A 5KN9A 3FHGA 2NOEA 2OFIA 4DK9A 1MUNA 3OH6A 1YQLA 2NOHA 1YQKA 1LWYA 3I0XA 3CVTA 2ABKA 3FHFA 4YPRA 3OH9A 3CWAA 1MUYA 1LWVA 1WEGA 1XQOA 1ORNA 4AIAA 2NOFA 3IHOA 4AI4A 1KG4A 1HU0A 1EBMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1LMZ A;  1XQP A;  4OFE A;  1RRS A;  3N5N X;  1N3C A;  1WEF A;  1PU8 A;  1KO9 A;  1WEI A;  1KG2 A;  4YPH A;  4E9E A;  1VRL A;  4EJY A;  2XHI A;  4EA5 A;  4OFH A;  3CVS A;  1P7M A;  3F0Z A;  3OGD A;  1KG3 A;  4EA4 A;  5AN4 A;  3CWS A;  3KTU A;  1NGN A;  3CWU A;  4OFA A;  1KEA A;  1KG6 A;  1PVS A;  3KNT A;  2OFK A;  2JG6 A;  4PII A;  3S6I A;  4EW4 A;  1RRQ A;  2I5W A;  1M3H A;  1FN7 A;  3FSP A;  4E9G A;  4EW0 A;  3N0U A;  1MUD A;  2NOL A;  1M3Q A;  1PU6 A;  4HSB A;  1ORP A;  1KQJ A;  3G0Q A;  2YG9 A;  4E9F A;  1YQR A;  2NOB A;  1N39 A;  4AI5 A;  4UNF A;  5KN8 A;  2NOZ A;  1KG7 A;  4B23 A;  3IH7 A;  4EVV A;  4E9H A;  1MPG A;  3CW7 A;  1DIZ A;  1P59 A;  2YG8 A;  4B21 A;  3I0W A;  4B22 A;  1PU7 A;  1LWW A;  1XG7 A;  2JHN A;  2JHJ A;  2NOI A;  3F10 A;  1YQM A;  5DPK A;  1KG5 A;  4YOQ A;  5CHZ A;  4EJZ A;  4UOB A;  1N3A A;  3CWT A;  1NKU A;  2H56 A;  3D4V A;  4B24 A;  5KN9 A;  3FHG A;  2NOE A;  2OFI A;  4DK9 A;  1MUN A;  3OH6 A;  1YQL A;  2NOH A;  1YQK A;  1LWY A;  3I0X A;  3CVT A;  2ABK A;  3FHF A;  4YPR A;  3OH9 A;  3CWA A;  1MUY A;  1LWV A;  1WEG A;  1XQO A;  1ORN A;  4AIA A;  2NOF A;  3IHO A;  4AI4 A;  1KG4 A;  1HU0 A;  1EBM A; 
#chains in the Genus database with same CATH topology
 1LMZ A;  1XQP A;  4OFE A;  3OYD A;  3OYG A;  4BE2 A;  3OY9 A;  3VW4 A;  3S3M A;  1RRS A;  3N5N X;  3S3N A;  1N3C A;  1WEF A;  1PU8 A;  1KO9 A;  1WEI A;  1KG2 A;  3OYJ A;  4YPH A;  4E9E A;  1VRL A;  3OYK A;  4EJY A;  3OYM A;  2XHI A;  4EA5 A;  4OFH A;  3L2Q A;  3CVS A;  1P7M A;  3F0Z A;  3R2X C;  3OGD A;  1KG3 A;  4EA4 A;  5AN4 A;  3CWS A;  5FRN A;  3KTU A;  1NGN A;  2W03 A;  3NNQ A;  3CWU A;  4BE0 A;  4OFA A;  1KEA A;  1KG6 A;  1PVS A;  3KNT A;  2OFK A;  2JG6 A;  4PII A;  2W04 A;  3S6I A;  4EW4 A;  4E7J A;  1RRQ A;  2I5W A;  1M3H A;  1FN7 A;  3FSP A;  4BDZ A;  4E9G A;  3L2W A;  3OYB A;  3L2U A;  4EW0 A;  3N0U A;  3OYI A;  1MUD A;  2NOL A;  1M3Q A;  1PU6 A;  4HSB A;  1ORP A;  1KQJ A;  4E7I A;  3G0Q A;  2YG9 A;  4BAC A;  3OS0 A;  4E9F A;  3OYH A;  3OYL A;  1YQR A;  2NOB A;  3OYC A;  1N39 A;  3L2R A;  4AI5 A;  4UNF A;  5KN8 A;  2NOZ A;  1KG7 A;  4B23 A;  3IH7 A;  4EVV A;  4E9H A;  1MPG A;  3CW7 A;  1DIZ A;  1P59 A;  2YG8 A;  4B21 A;  3I0W A;  3OYN A;  4B22 A;  1PU7 A;  1LWW A;  1XG7 A;  2JHN A;  4E7L A;  1U84 A;  3OS1 A;  2JHJ A;  4ZTJ A;  2NOI A;  3F10 A;  5FRO A;  3OYA A;  1YQM A;  5DPK A;  1KG5 A;  4YOQ A;  5CHZ A;  4EJZ A;  4UOB A;  1N3A A;  3CWT A;  1NKU A;  2H56 A;  4E7H A;  4E7K A;  3LCN A;  3D4V A;  4ZTF A;  4B24 A;  5KN9 A;  3FHG A;  2NOE A;  2OFI A;  3OYE A;  4DK9 A;  4BDY A;  1MUN A;  3OH6 A;  1YQL A;  2NOH A;  1YQK A;  1LWY A;  3I0X A;  3OYF A;  3L2V A;  3CVT A;  2ABK A;  4IKF A;  3FHF A;  4YPR A;  3OH9 A;  4BE1 A;  3CWA A;  1MUY A;  1LWV A;  1WEG A;  4NZG A;  3OS2 A;  1XQO A;  2V75 A;  1ORN A;  4AIA A;  2NOF A;  3S3O A;  3IHO A;  4AI4 A;  5FRM A;  2JPS A;  1KG4 A;  1HU0 A;  1EBM A; 
#chains in the Genus database with same CATH homology
 1LMZ A;  1XQP A;  4OFE A;  1RRS A;  3N5N X;  1N3C A;  1WEF A;  1PU8 A;  1KO9 A;  1WEI A;  1KG2 A;  4YPH A;  4E9E A;  1VRL A;  4EJY A;  2XHI A;  4EA5 A;  4OFH A;  3CVS A;  1P7M A;  3F0Z A;  3OGD A;  1KG3 A;  4EA4 A;  5AN4 A;  3CWS A;  3KTU A;  1NGN A;  3CWU A;  4OFA A;  1KEA A;  1KG6 A;  1PVS A;  3KNT A;  2OFK A;  2JG6 A;  4PII A;  3S6I A;  4EW4 A;  1RRQ A;  2I5W A;  1M3H A;  1FN7 A;  3FSP A;  4E9G A;  4EW0 A;  3N0U A;  1MUD A;  2NOL A;  1M3Q A;  1PU6 A;  4HSB A;  1ORP A;  1KQJ A;  3G0Q A;  2YG9 A;  4E9F A;  1YQR A;  2NOB A;  1N39 A;  4AI5 A;  4UNF A;  5KN8 A;  2NOZ A;  1KG7 A;  4B23 A;  3IH7 A;  4EVV A;  4E9H A;  1MPG A;  3CW7 A;  1DIZ A;  1P59 A;  2YG8 A;  4B21 A;  3I0W A;  4B22 A;  1PU7 A;  1LWW A;  1XG7 A;  2JHN A;  2JHJ A;  2NOI A;  3F10 A;  1YQM A;  5DPK A;  1KG5 A;  4YOQ A;  5CHZ A;  4EJZ A;  4UOB A;  1N3A A;  3CWT A;  1NKU A;  2H56 A;  3D4V A;  4B24 A;  5KN9 A;  3FHG A;  2NOE A;  2OFI A;  4DK9 A;  1MUN A;  3OH6 A;  1YQL A;  2NOH A;  1YQK A;  1LWY A;  3I0X A;  3CVT A;  2ABK A;  3FHF A;  4YPR A;  3OH9 A;  3CWA A;  1MUY A;  1LWV A;  1WEG A;  1XQO A;  1ORN A;  4AIA A;  2NOF A;  3IHO A;  4AI4 A;  1KG4 A;  1HU0 A;  1EBM A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...