4EA5A

Structure of the glycoslyase domain of mbd4 bound to a 5hmu containing dna
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
136
structure length
136
Chain Sequence
TPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEAHKLNKYHDWLWENH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/dna
molecule keywords Methyl-CpG-binding domain protein 4
publication title Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.
pubmed doi rcsb
source organism Homo sapiens
total genus 49
structure length 136
sequence length 136
ec nomenclature ec 3.2.2.-:
pdb deposition date 2012-03-22
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4ea5A00
4EVVA 4YPRA 3OH9A 1KG5A 4OFEA 4UOBA 1VRLA 1P7MA 1FN7A 4EJZA 1YQLA 2NOLA 3I0WA 2NOEA 4YPHA 1PVSA 2NOBA 4OFHA 3CWSA 1LWYA 3CW7A 4B24A 1PU6A 1PU7A 3FSPA 3N0UA 3G0QA 1XQPA 4E9GA 4B23A 2YG9A 2JG6A 4B21A 4EW0A 3S6IA 1ORPA 3OH6A 1P59A 1HU0A 3N5NX 4EJYA 1N39A 4E9FA 1NGNA 1NKUA 1N3CA 1LWWA 3CWAA 4AIAA 2I5WA 1WEGA 1N3AA 1WEFA 1RRSA 1LWVA 3FHGA 2OFKA 5KN9A 2NOFA 4B22A 2XHIA 1EBMA 3I0XA 2NOZA 1DIZA 1XQOA 3CVSA 1LMZA 4PIIA 4EA5A 1KG3A 4EW4A 1KG4A 2H56A 5AN4A 3D4VA 1KEAA 3F10A 5KN8A 2JHJA 1M3QA 2OFIA 3F0ZA 1KQJA 1WEIA 4AI5A 1YQKA 1MUDA 1KG2A 3IHOA 1M3HA 4HSBA 3CWTA 2ABKA 1MPGA 1RRQA 2NOIA 2YG8A 4UNFA 1PU8A 4YOQA 3KTUA 1MUNA 3OGDA 1KG7A 4AI4A 4E9EA 1YQRA 2NOHA 3KNTA 2JHNA 1YQMA 1ORNA 4OFAA 1KO9A 4E9HA 3CVTA 4DK9A 3IH7A 4EA4A 3CWUA 1MUYA 1XG7A 3FHFA 5DPKA 5CHZA 1KG6A
chains in the Genus database with same CATH superfamily
4EVVA 4YPRA 3OH9A 3OYFA 1KG5A 4OFEA 4UOBA 3L2QA 1VRLA 1P7MA 1FN7A 4EJZA 1YQLA 4E7HA 2NOLA 3I0WA 2NOEA 4YPHA 3OY9A 1PVSA 2NOBA 4OFHA 3CWSA 1LWYA 1U84A 4E7LA 3CW7A 4B24A 1PU6A 1PU7A 4BACA 3OYCA 3FSPA 3N0UA 3G0QA 5FROA 3OYLA 3OYNA 4IKFA 1XQPA 4E9GA 4B23A 2YG9A 2JG6A 3NNQA 3L2RA 2W03A 4B21A 4EW0A 3S6IA 4E7JA 1ORPA 3OH6A 1P59A 1HU0A 3N5NX 2V75A 3OYEA 4ZTFA 4EJYA 3OS1A 1N39A 4E9FA 2JPSA 1NGNA 1NKUA 1N3CA 3OYHA 3OYJA 1LWWA 3CWAA 4AIAA 4ZTJA 2I5WA 1WEGA 1N3AA 1WEFA 1RRSA 1LWVA 3OYKA 3LCNA 3OS2A 3FHGA 2OFKA 5KN9A 3OYAA 3OYDA 2NOFA 4B22A 4E7KA 3S3OA 5FRMA 2XHIA 1EBMA 3I0XA 2NOZA 1DIZA 1XQOA 3CVSA 1LMZA 4BE2A 4PIIA 4EA5A 1KG3A 4EW4A 5FRNA 1KG4A 3OYIA 2H56A 5AN4A 3D4VA 3VW4A 4NZGA 3OS0A 1KEAA 3F10A 4BE0A 5KN8A 2JHJA 1M3QA 2OFIA 3F0ZA 1KQJA 3R2XC 1WEIA 4AI5A 3L2VA 3S3NA 3OYGA 1YQKA 1MUDA 1KG2A 3L2UA 3IHOA 1M3HA 4HSBA 3CWTA 2ABKA 4BDYA 1MPGA 3L2WA 1RRQA 2NOIA 2YG8A 4UNFA 1PU8A 4YOQA 3KTUA 1MUNA 3OGDA 1KG7A 4AI4A 4E9EA 4BDZA 1YQRA 2NOHA 3KNTA 2JHNA 1YQMA 1ORNA 4E7IA 3S3MA 3OYBA 2W04A 4OFAA 1KO9A 4BE1A 4E9HA 4DK9A 3IH7A 4EA4A 3CVTA 3CWUA 1MUYA 1XG7A 3FHFA 5DPKA 5CHZA 3OYMA 1KG6A
chains in the Genus database with same CATH topology
4EVVA 4YPRA 3OH9A 1KG5A 4OFEA 4UOBA 1VRLA 1P7MA 1FN7A 4EJZA 1YQLA 2NOLA 3I0WA 2NOEA 4YPHA 1PVSA 2NOBA 4OFHA 3CWSA 1LWYA 3CW7A 4B24A 1PU6A 1PU7A 3FSPA 3N0UA 3G0QA 1XQPA 4E9GA 4B23A 2YG9A 2JG6A 4B21A 4EW0A 3S6IA 1ORPA 3OH6A 1P59A 1HU0A 3N5NX 4EJYA 1N39A 4E9FA 1NGNA 1NKUA 1N3CA 1LWWA 3CWAA 4AIAA 2I5WA 1WEGA 1N3AA 1WEFA 1RRSA 1LWVA 3FHGA 2OFKA 5KN9A 2NOFA 4B22A 2XHIA 1EBMA 3I0XA 2NOZA 1DIZA 1XQOA 3CVSA 1LMZA 4PIIA 4EA5A 1KG3A 4EW4A 1KG4A 2H56A 5AN4A 3D4VA 1KEAA 3F10A 5KN8A 2JHJA 1M3QA 2OFIA 3F0ZA 1KQJA 1WEIA 4AI5A 1YQKA 1MUDA 1KG2A 3IHOA 1M3HA 4HSBA 3CWTA 2ABKA 1MPGA 1RRQA 2NOIA 2YG8A 4UNFA 1PU8A 4YOQA 3KTUA 1MUNA 3OGDA 1KG7A 4AI4A 4E9EA 1YQRA 2NOHA 3KNTA 2JHNA 1YQMA 1ORNA 4OFAA 1KO9A 4E9HA 3CVTA 4DK9A 3IH7A 4EA4A 3CWUA 1MUYA 1XG7A 3FHFA 5DPKA 5CHZA 1KG6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4EVV A;  4YPR A;  3OH9 A;  1KG5 A;  4OFE A;  4UOB A;  1VRL A;  1P7M A;  1FN7 A;  4EJZ A;  1YQL A;  2NOL A;  3I0W A;  2NOE A;  4YPH A;  1PVS A;  2NOB A;  4OFH A;  3CWS A;  1LWY A;  3CW7 A;  4B24 A;  1PU6 A;  1PU7 A;  3FSP A;  3N0U A;  3G0Q A;  1XQP A;  4E9G A;  4B23 A;  2YG9 A;  2JG6 A;  4B21 A;  4EW0 A;  3S6I A;  1ORP A;  3OH6 A;  1P59 A;  1HU0 A;  3N5N X;  4EJY A;  1N39 A;  4E9F A;  1NGN A;  1NKU A;  1N3C A;  1LWW A;  3CWA A;  4AIA A;  2I5W A;  1WEG A;  1N3A A;  1WEF A;  1RRS A;  1LWV A;  3FHG A;  2OFK A;  5KN9 A;  2NOF A;  4B22 A;  2XHI A;  1EBM A;  3I0X A;  2NOZ A;  1DIZ A;  1XQO A;  3CVS A;  1LMZ A;  4PII A;  4EA5 A;  1KG3 A;  4EW4 A;  1KG4 A;  2H56 A;  5AN4 A;  3D4V A;  1KEA A;  3F10 A;  5KN8 A;  2JHJ A;  1M3Q A;  2OFI A;  3F0Z A;  1KQJ A;  1WEI A;  4AI5 A;  1YQK A;  1MUD A;  1KG2 A;  3IHO A;  1M3H A;  4HSB A;  3CWT A;  2ABK A;  1MPG A;  1RRQ A;  2NOI A;  2YG8 A;  4UNF A;  1PU8 A;  4YOQ A;  3KTU A;  1MUN A;  3OGD A;  1KG7 A;  4AI4 A;  4E9E A;  1YQR A;  2NOH A;  3KNT A;  2JHN A;  1YQM A;  1ORN A;  4OFA A;  1KO9 A;  4E9H A;  3CVT A;  4DK9 A;  3IH7 A;  4EA4 A;  3CWU A;  1MUY A;  1XG7 A;  3FHF A;  5DPK A;  5CHZ A;  1KG6 A; 
#chains in the Genus database with same CATH topology
 4EVV A;  4YPR A;  3OH9 A;  3OYF A;  1KG5 A;  4OFE A;  4UOB A;  3L2Q A;  1VRL A;  1P7M A;  1FN7 A;  4EJZ A;  1YQL A;  4E7H A;  2NOL A;  3I0W A;  2NOE A;  4YPH A;  3OY9 A;  1PVS A;  2NOB A;  4OFH A;  3CWS A;  1LWY A;  1U84 A;  4E7L A;  3CW7 A;  4B24 A;  1PU6 A;  1PU7 A;  4BAC A;  3OYC A;  3FSP A;  3N0U A;  3G0Q A;  5FRO A;  3OYL A;  3OYN A;  4IKF A;  1XQP A;  4E9G A;  4B23 A;  2YG9 A;  2JG6 A;  3NNQ A;  3L2R A;  2W03 A;  4B21 A;  4EW0 A;  3S6I A;  4E7J A;  1ORP A;  3OH6 A;  1P59 A;  1HU0 A;  3N5N X;  2V75 A;  3OYE A;  4ZTF A;  4EJY A;  3OS1 A;  1N39 A;  4E9F A;  2JPS A;  1NGN A;  1NKU A;  1N3C A;  3OYH A;  3OYJ A;  1LWW A;  3CWA A;  4AIA A;  4ZTJ A;  2I5W A;  1WEG A;  1N3A A;  1WEF A;  1RRS A;  1LWV A;  3OYK A;  3LCN A;  3OS2 A;  3FHG A;  2OFK A;  5KN9 A;  3OYA A;  3OYD A;  2NOF A;  4B22 A;  4E7K A;  3S3O A;  5FRM A;  2XHI A;  1EBM A;  3I0X A;  2NOZ A;  1DIZ A;  1XQO A;  3CVS A;  1LMZ A;  4BE2 A;  4PII A;  4EA5 A;  1KG3 A;  4EW4 A;  5FRN A;  1KG4 A;  3OYI A;  2H56 A;  5AN4 A;  3D4V A;  3VW4 A;  4NZG A;  3OS0 A;  1KEA A;  3F10 A;  4BE0 A;  5KN8 A;  2JHJ A;  1M3Q A;  2OFI A;  3F0Z A;  1KQJ A;  3R2X C;  1WEI A;  4AI5 A;  3L2V A;  3S3N A;  3OYG A;  1YQK A;  1MUD A;  1KG2 A;  3L2U A;  3IHO A;  1M3H A;  4HSB A;  3CWT A;  2ABK A;  4BDY A;  1MPG A;  3L2W A;  1RRQ A;  2NOI A;  2YG8 A;  4UNF A;  1PU8 A;  4YOQ A;  3KTU A;  1MUN A;  3OGD A;  1KG7 A;  4AI4 A;  4E9E A;  4BDZ A;  1YQR A;  2NOH A;  3KNT A;  2JHN A;  1YQM A;  1ORN A;  4E7I A;  3S3M A;  3OYB A;  2W04 A;  4OFA A;  1KO9 A;  4BE1 A;  4E9H A;  4DK9 A;  3IH7 A;  4EA4 A;  3CVT A;  3CWU A;  1MUY A;  1XG7 A;  3FHF A;  5DPK A;  5CHZ A;  3OYM A;  1KG6 A; 
#chains in the Genus database with same CATH homology
 4EVV A;  4YPR A;  3OH9 A;  1KG5 A;  4OFE A;  4UOB A;  1VRL A;  1P7M A;  1FN7 A;  4EJZ A;  1YQL A;  2NOL A;  3I0W A;  2NOE A;  4YPH A;  1PVS A;  2NOB A;  4OFH A;  3CWS A;  1LWY A;  3CW7 A;  4B24 A;  1PU6 A;  1PU7 A;  3FSP A;  3N0U A;  3G0Q A;  1XQP A;  4E9G A;  4B23 A;  2YG9 A;  2JG6 A;  4B21 A;  4EW0 A;  3S6I A;  1ORP A;  3OH6 A;  1P59 A;  1HU0 A;  3N5N X;  4EJY A;  1N39 A;  4E9F A;  1NGN A;  1NKU A;  1N3C A;  1LWW A;  3CWA A;  4AIA A;  2I5W A;  1WEG A;  1N3A A;  1WEF A;  1RRS A;  1LWV A;  3FHG A;  2OFK A;  5KN9 A;  2NOF A;  4B22 A;  2XHI A;  1EBM A;  3I0X A;  2NOZ A;  1DIZ A;  1XQO A;  3CVS A;  1LMZ A;  4PII A;  4EA5 A;  1KG3 A;  4EW4 A;  1KG4 A;  2H56 A;  5AN4 A;  3D4V A;  1KEA A;  3F10 A;  5KN8 A;  2JHJ A;  1M3Q A;  2OFI A;  3F0Z A;  1KQJ A;  1WEI A;  4AI5 A;  1YQK A;  1MUD A;  1KG2 A;  3IHO A;  1M3H A;  4HSB A;  3CWT A;  2ABK A;  1MPG A;  1RRQ A;  2NOI A;  2YG8 A;  4UNF A;  1PU8 A;  4YOQ A;  3KTU A;  1MUN A;  3OGD A;  1KG7 A;  4AI4 A;  4E9E A;  1YQR A;  2NOH A;  3KNT A;  2JHN A;  1YQM A;  1ORN A;  4OFA A;  1KO9 A;  4E9H A;  3CVT A;  4DK9 A;  3IH7 A;  4EA4 A;  3CWU A;  1MUY A;  1XG7 A;  3FHF A;  5DPK A;  5CHZ A;  1KG6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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