4OFEA

Structural basis for thymine glycosylase activity on t:o6-methylg mismatch by methyl-cpg binding domain protein 4: implications for roles of arg468 in mismatch recognition and catalysis
Total Genus 51
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
51
sequence length
142
structure length
142
Chain Sequence
WTPPRSPFNLVQETLFHDPWKLLIATIFLNKTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPENHKLNKYHDWLWENHEKLSL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/dna
molecule keywords Methyl-CpG-binding domain protein 4
publication title Structure of R468K/D560N MBD4 bound to G:T mispair DNA
rcsb
source organism Homo sapiens
total genus 51
structure length 142
sequence length 142
ec nomenclature ec 3.2.2.-:
pdb deposition date 2014-01-14
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4ofeA00
2I5WA 3S6IA 2JHNA 1M3HA 1LMZA 2JHJA 1LWYA 4HSBA 1LWVA 2NOZA 1P59A 1KG2A 4DK9A 3KNTA 1M3QA 1YQMA 1XG7A 1HU0A 1MUNA 1FN7A 2YG9A 1MUDA 4B22A 1ORPA 4EA4A 2NOFA 4EW4A 4OFAA 3D4VA 2NOHA 2XHIA 5CHZA 2ABKA 1NGNA 3IHOA 4AI5A 1RRSA 4EJZA 4YPHA 5KN9A 1N3CA 1VRLA 1KO9A 1YQRA 1DIZA 3FSPA 3OH6A 4YPRA 3F10A 2OFIA 3I0XA 1N3AA 4UOBA 2H56A 5KN8A 3G0QA 4E9HA 3IH7A 2NOBA 3CWSA 4YOQA 1KQJA 1WEFA 1KG6A 3CWAA 1P7MA 5AN4A 1RRQA 3N0UA 2NOIA 1PU6A 2YG8A 3N5NX 1KG4A 4B23A 3F0ZA 4OFHA 4B24A 4AIAA 2NOEA 4EW0A 1YQLA 1MPGA 4OFEA 4EJYA 1WEGA 3I0WA 1MUYA 4E9EA 2NOLA 1KG3A 2OFKA 3CWUA 5DPKA 3CW7A 1N39A 1PU7A 3FHGA 2JG6A 3OH9A 1KEAA 3CVTA 1ORNA 1PU8A 4PIIA 1EBMA 3CWTA 1KG7A 1YQKA 4EA5A 1LWWA 4B21A 3KTUA 1WEIA 4UNFA 1XQOA 4E9FA 4E9GA 1XQPA 1NKUA 4EVVA 3CVSA 1PVSA 3OGDA 3FHFA 4AI4A 1KG5A
chains in the Genus database with same CATH superfamily
2I5WA 3S6IA 2JHNA 1U84A 1M3HA 4BDZA 1LMZA 2JHJA 1LWYA 4HSBA 1LWVA 2NOZA 1P59A 1KG2A 4DK9A 3KNTA 1M3QA 1YQMA 1XG7A 3LCNA 1HU0A 1MUNA 1FN7A 2YG9A 1MUDA 4B22A 3OYNA 1ORPA 4BDYA 4EA4A 4EW4A 2NOFA 4OFAA 3S3NA 3D4VA 2NOHA 3L2VA 2XHIA 3S3OA 5CHZA 2ABKA 3OYFA 1NGNA 3IHOA 4AI5A 1RRSA 4IKFA 4EJZA 4YPHA 3OY9A 5KN9A 3OYGA 3L2RA 1N3CA 1VRLA 1KO9A 1YQRA 1DIZA 3NNQA 3OYHA 2JPSA 4BACA 3OH6A 3FSPA 4YPRA 3F10A 2OFIA 4E7LA 5FRNA 3I0XA 4ZTFA 3OYIA 4BE0A 3L2UA 5FRMA 5FROA 4UOBA 3OYAA 1N3AA 2H56A 3OYBA 5KN8A 3G0QA 4E7HA 3OS0A 4E9HA 3IH7A 2NOBA 3CWSA 4YOQA 4BE2A 1KQJA 1WEFA 2W04A 4NZGA 1KG6A 3CWAA 1P7MA 5AN4A 3OYMA 1RRQA 3OYLA 3N0UA 2NOIA 1PU6A 3S3MA 2YG8A 3N5NX 1KG4A 3OYKA 4B23A 3F0ZA 3OYDA 4OFHA 2W03A 4B24A 4ZTJA 4AIAA 2NOEA 4EW0A 1YQLA 3OYEA 1MPGA 4OFEA 4EJYA 4BE1A 1WEGA 3I0WA 1MUYA 4E9EA 3OYJA 2NOLA 1KG3A 2OFKA 3CWUA 4E7IA 3OS2A 5DPKA 3CW7A 1N39A 1PU7A 3L2QA 3FHGA 2JG6A 3OH9A 1KEAA 3CVTA 1ORNA 1PU8A 2V75A 4PIIA 1EBMA 3OYCA 1KG7A 1YQKA 4EA5A 3CWTA 1LWWA 4B21A 3KTUA 1WEIA 4UNFA 1XQOA 4E9FA 4E7JA 4E9GA 1XQPA 1NKUA 3OS1A 3VW4A 4EVVA 3CVSA 1PVSA 3OGDA 3R2XC 4E7KA 3FHFA 4AI4A 3L2WA 1KG5A
chains in the Genus database with same CATH topology
2I5WA 3S6IA 2JHNA 1M3HA 1LMZA 2JHJA 1LWYA 4HSBA 1LWVA 2NOZA 1P59A 1KG2A 4DK9A 3KNTA 1M3QA 1YQMA 1XG7A 1HU0A 1MUNA 1FN7A 2YG9A 1MUDA 4B22A 1ORPA 4EA4A 2NOFA 4EW4A 4OFAA 3D4VA 2NOHA 2XHIA 5CHZA 2ABKA 1NGNA 3IHOA 4AI5A 1RRSA 4EJZA 4YPHA 5KN9A 1N3CA 1VRLA 1KO9A 1YQRA 1DIZA 3FSPA 3OH6A 4YPRA 3F10A 2OFIA 3I0XA 1N3AA 4UOBA 2H56A 5KN8A 3G0QA 4E9HA 3IH7A 2NOBA 3CWSA 4YOQA 1KQJA 1WEFA 1KG6A 3CWAA 1P7MA 5AN4A 1RRQA 3N0UA 2NOIA 1PU6A 2YG8A 3N5NX 1KG4A 4B23A 3F0ZA 4OFHA 4B24A 4AIAA 2NOEA 4EW0A 1YQLA 1MPGA 4OFEA 4EJYA 1WEGA 3I0WA 1MUYA 4E9EA 2NOLA 1KG3A 2OFKA 3CWUA 5DPKA 3CW7A 1N39A 1PU7A 3FHGA 2JG6A 3OH9A 1KEAA 3CVTA 1ORNA 1PU8A 4PIIA 1EBMA 3CWTA 1KG7A 1YQKA 4EA5A 1LWWA 4B21A 3KTUA 1WEIA 4UNFA 1XQOA 4E9FA 4E9GA 1XQPA 1NKUA 4EVVA 3CVSA 1PVSA 3OGDA 3FHFA 4AI4A 1KG5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2I5W A;  3S6I A;  2JHN A;  1M3H A;  1LMZ A;  2JHJ A;  1LWY A;  4HSB A;  1LWV A;  2NOZ A;  1P59 A;  1KG2 A;  4DK9 A;  3KNT A;  1M3Q A;  1YQM A;  1XG7 A;  1HU0 A;  1MUN A;  1FN7 A;  2YG9 A;  1MUD A;  4B22 A;  1ORP A;  4EA4 A;  2NOF A;  4EW4 A;  4OFA A;  3D4V A;  2NOH A;  2XHI A;  5CHZ A;  2ABK A;  1NGN A;  3IHO A;  4AI5 A;  1RRS A;  4EJZ A;  4YPH A;  5KN9 A;  1N3C A;  1VRL A;  1KO9 A;  1YQR A;  1DIZ A;  3FSP A;  3OH6 A;  4YPR A;  3F10 A;  2OFI A;  3I0X A;  1N3A A;  4UOB A;  2H56 A;  5KN8 A;  3G0Q A;  4E9H A;  3IH7 A;  2NOB A;  3CWS A;  4YOQ A;  1KQJ A;  1WEF A;  1KG6 A;  3CWA A;  1P7M A;  5AN4 A;  1RRQ A;  3N0U A;  2NOI A;  1PU6 A;  2YG8 A;  3N5N X;  1KG4 A;  4B23 A;  3F0Z A;  4OFH A;  4B24 A;  4AIA A;  2NOE A;  4EW0 A;  1YQL A;  1MPG A;  4OFE A;  4EJY A;  1WEG A;  3I0W A;  1MUY A;  4E9E A;  2NOL A;  1KG3 A;  2OFK A;  3CWU A;  5DPK A;  3CW7 A;  1N39 A;  1PU7 A;  3FHG A;  2JG6 A;  3OH9 A;  1KEA A;  3CVT A;  1ORN A;  1PU8 A;  4PII A;  1EBM A;  3CWT A;  1KG7 A;  1YQK A;  4EA5 A;  1LWW A;  4B21 A;  3KTU A;  1WEI A;  4UNF A;  1XQO A;  4E9F A;  4E9G A;  1XQP A;  1NKU A;  4EVV A;  3CVS A;  1PVS A;  3OGD A;  3FHF A;  4AI4 A;  1KG5 A; 
#chains in the Genus database with same CATH topology
 2I5W A;  3S6I A;  2JHN A;  1U84 A;  1M3H A;  4BDZ A;  1LMZ A;  2JHJ A;  1LWY A;  4HSB A;  1LWV A;  2NOZ A;  1P59 A;  1KG2 A;  4DK9 A;  3KNT A;  1M3Q A;  1YQM A;  1XG7 A;  3LCN A;  1HU0 A;  1MUN A;  1FN7 A;  2YG9 A;  1MUD A;  4B22 A;  3OYN A;  1ORP A;  4BDY A;  4EA4 A;  4EW4 A;  2NOF A;  4OFA A;  3S3N A;  3D4V A;  2NOH A;  3L2V A;  2XHI A;  3S3O A;  5CHZ A;  2ABK A;  3OYF A;  1NGN A;  3IHO A;  4AI5 A;  1RRS A;  4IKF A;  4EJZ A;  4YPH A;  3OY9 A;  5KN9 A;  3OYG A;  3L2R A;  1N3C A;  1VRL A;  1KO9 A;  1YQR A;  1DIZ A;  3NNQ A;  3OYH A;  2JPS A;  4BAC A;  3OH6 A;  3FSP A;  4YPR A;  3F10 A;  2OFI A;  4E7L A;  5FRN A;  3I0X A;  4ZTF A;  3OYI A;  4BE0 A;  3L2U A;  5FRM A;  5FRO A;  4UOB A;  3OYA A;  1N3A A;  2H56 A;  3OYB A;  5KN8 A;  3G0Q A;  4E7H A;  3OS0 A;  4E9H A;  3IH7 A;  2NOB A;  3CWS A;  4YOQ A;  4BE2 A;  1KQJ A;  1WEF A;  2W04 A;  4NZG A;  1KG6 A;  3CWA A;  1P7M A;  5AN4 A;  3OYM A;  1RRQ A;  3OYL A;  3N0U A;  2NOI A;  1PU6 A;  3S3M A;  2YG8 A;  3N5N X;  1KG4 A;  3OYK A;  4B23 A;  3F0Z A;  3OYD A;  4OFH A;  2W03 A;  4B24 A;  4ZTJ A;  4AIA A;  2NOE A;  4EW0 A;  1YQL A;  3OYE A;  1MPG A;  4OFE A;  4EJY A;  4BE1 A;  1WEG A;  3I0W A;  1MUY A;  4E9E A;  3OYJ A;  2NOL A;  1KG3 A;  2OFK A;  3CWU A;  4E7I A;  3OS2 A;  5DPK A;  3CW7 A;  1N39 A;  1PU7 A;  3L2Q A;  3FHG A;  2JG6 A;  3OH9 A;  1KEA A;  3CVT A;  1ORN A;  1PU8 A;  2V75 A;  4PII A;  1EBM A;  3OYC A;  1KG7 A;  1YQK A;  4EA5 A;  3CWT A;  1LWW A;  4B21 A;  3KTU A;  1WEI A;  4UNF A;  1XQO A;  4E9F A;  4E7J A;  4E9G A;  1XQP A;  1NKU A;  3OS1 A;  3VW4 A;  4EVV A;  3CVS A;  1PVS A;  3OGD A;  3R2X C;  4E7K A;  3FHF A;  4AI4 A;  3L2W A;  1KG5 A; 
#chains in the Genus database with same CATH homology
 2I5W A;  3S6I A;  2JHN A;  1M3H A;  1LMZ A;  2JHJ A;  1LWY A;  4HSB A;  1LWV A;  2NOZ A;  1P59 A;  1KG2 A;  4DK9 A;  3KNT A;  1M3Q A;  1YQM A;  1XG7 A;  1HU0 A;  1MUN A;  1FN7 A;  2YG9 A;  1MUD A;  4B22 A;  1ORP A;  4EA4 A;  2NOF A;  4EW4 A;  4OFA A;  3D4V A;  2NOH A;  2XHI A;  5CHZ A;  2ABK A;  1NGN A;  3IHO A;  4AI5 A;  1RRS A;  4EJZ A;  4YPH A;  5KN9 A;  1N3C A;  1VRL A;  1KO9 A;  1YQR A;  1DIZ A;  3FSP A;  3OH6 A;  4YPR A;  3F10 A;  2OFI A;  3I0X A;  1N3A A;  4UOB A;  2H56 A;  5KN8 A;  3G0Q A;  4E9H A;  3IH7 A;  2NOB A;  3CWS A;  4YOQ A;  1KQJ A;  1WEF A;  1KG6 A;  3CWA A;  1P7M A;  5AN4 A;  1RRQ A;  3N0U A;  2NOI A;  1PU6 A;  2YG8 A;  3N5N X;  1KG4 A;  4B23 A;  3F0Z A;  4OFH A;  4B24 A;  4AIA A;  2NOE A;  4EW0 A;  1YQL A;  1MPG A;  4OFE A;  4EJY A;  1WEG A;  3I0W A;  1MUY A;  4E9E A;  2NOL A;  1KG3 A;  2OFK A;  3CWU A;  5DPK A;  3CW7 A;  1N39 A;  1PU7 A;  3FHG A;  2JG6 A;  3OH9 A;  1KEA A;  3CVT A;  1ORN A;  1PU8 A;  4PII A;  1EBM A;  3CWT A;  1KG7 A;  1YQK A;  4EA5 A;  1LWW A;  4B21 A;  3KTU A;  1WEI A;  4UNF A;  1XQO A;  4E9F A;  4E9G A;  1XQP A;  1NKU A;  4EVV A;  3CVS A;  1PVS A;  3OGD A;  3FHF A;  4AI4 A;  1KG5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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