4OFEA

Structural basis for thymine glycosylase activity on t:o6-methylg mismatch by methyl-cpg binding domain protein 4: implications for roles of arg468 in mismatch recognition and catalysis
Total Genus 51
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
51
sequence length
142
structure length
142
Chain Sequence
WTPPRSPFNLVQETLFHDPWKLLIATIFLNKTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPENHKLNKYHDWLWENHEKLSL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure of R468K/D560N MBD4 bound to G:T mispair DNA
rcsb
source organism Homo sapiens
molecule tags Hydrolase/dna
molecule keywords Methyl-CpG-binding domain protein 4
total genus 51
structure length 142
sequence length 142
ec nomenclature ec 3.2.2.-:
pdb deposition date 2014-01-14
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4ofeA00
3D4VA 2YG8A 2H56A 1MUNA 1ORPA 1N3CA 1P59A 2XHIA 3N0UA 3FHFA 3IHOA 3IH7A 3I0WA 5KN9A 2NOBA 1NKUA 4EJZA 2OFIA 2NOFA 4EA4A 3N5NX 4AIAA 1P7MA 4AI4A 1XQOA 1LWWA 1YQMA 1N3AA 2NOIA 1XG7A 4B21A 4B24A 1KG4A 1XQPA 1DIZA 3I0XA 5AN4A 1LWYA 4UOBA 1ORNA 1PU8A 1MPGA 4YOQA 2JHJA 4EW0A 4DK9A 1WEFA 3CVTA 1KG6A 1KO9A 1KG7A 4EVVA 4YPHA 4HSBA 2YG9A 3F0ZA 2NOEA 1RRSA 3CWTA 3KNTA 1KG3A 3FSPA 3G0QA 3CWAA 1KEAA 4PIIA 2JHNA 2JG6A 3FHGA 1KG2A 4E9EA 1FN7A 1KQJA 1WEGA 1EBMA 3CW7A 4E9FA 3CWSA 3OH9A 1PU7A 4YPRA 4EA5A 1MUDA 1LWVA 4E9GA 1YQLA 1M3HA 3CWUA 1LMZA 3S6IA 3OH6A 4E9HA 5CHZA 1WEIA 4EJYA 4EW4A 2NOHA 2NOZA 1NGNA 1HU0A 5KN8A 4UNFA 3OGDA 1N39A 4OFHA 1RRQA 1PU6A 1M3QA 2NOLA 1MUYA 2I5WA 4OFAA 4B22A 4OFEA 2OFKA 1YQRA 1YQKA 5DPKA 3F10A 3CVSA 4AI5A 3KTUA 1PVSA 4B23A 2ABKA 1VRLA 1KG5A
chains in the Genus database with same CATH superfamily
3D4VA 2YG8A 2H56A 1MUNA 1ORPA 1N3CA 4BDYA 1P59A 2XHIA 3L2WA 3N0UA 3FHFA 3R2XC 3IHOA 3IH7A 4BE0A 4E7LA 3I0WA 5KN9A 3L2RA 2NOBA 1NKUA 2W04A 3L2VA 2V75A 4EJZA 2OFIA 2NOFA 4BE2A 4EA4A 3N5NX 4AIAA 1P7MA 4AI4A 3OS1A 1XQOA 3OYAA 3OYJA 1LWWA 1YQMA 1N3AA 2NOIA 1XG7A 4B21A 5FRNA 3OY9A 4B24A 1KG4A 1XQPA 1DIZA 2W03A 4BE1A 3OYEA 3I0XA 3OS0A 3S3MA 5AN4A 1LWYA 4UOBA 1ORNA 1PU8A 1MPGA 4YOQA 2JHJA 4EW0A 4DK9A 1WEFA 3LCNA 4ZTFA 3CVTA 1KG6A 1KO9A 1KG7A 4EVVA 4YPHA 3OS2A 4HSBA 2YG9A 3F0ZA 2NOEA 3OYMA 4ZTJA 1RRSA 3KNTA 1U84A 3CWTA 1KG3A 3FSPA 3G0QA 3CWAA 1KEAA 3VW4A 4PIIA 2JHNA 2JG6A 3FHGA 1KG2A 4E9EA 1FN7A 1KQJA 1WEGA 3OYLA 1EBMA 3CW7A 4E9FA 4BDZA 3CWSA 3OH9A 3OYGA 4E7KA 1PU7A 4YPRA 4EA5A 1MUDA 1LWVA 4E9GA 5FROA 4E7IA 1YQLA 1M3HA 3CWUA 1LMZA 3S6IA 2JPSA 3OYDA 3L2QA 3OH6A 3S3NA 4E9HA 5CHZA 1WEIA 3OYBA 3OYFA 3OYHA 3OYNA 4EJYA 3NNQA 4EW4A 3S3OA 2NOHA 2NOZA 1NGNA 1HU0A 5KN8A 4UNFA 4BACA 3OGDA 3OYKA 1N39A 4OFHA 1RRQA 4E7JA 4IKFA 1PU6A 1M3QA 2NOLA 3L2UA 4NZGA 3OYIA 1MUYA 2I5WA 4OFAA 4E7HA 4B22A 3OYCA 4OFEA 2OFKA 1YQRA 1YQKA 5DPKA 3F10A 3CVSA 4AI5A 3KTUA 1PVSA 5FRMA 4B23A 2ABKA 1VRLA 1KG5A
chains in the Genus database with same CATH topology
3D4VA 2YG8A 2H56A 1MUNA 1ORPA 1N3CA 1P59A 2XHIA 3N0UA 3FHFA 3IHOA 3IH7A 3I0WA 5KN9A 2NOBA 1NKUA 4EJZA 2OFIA 2NOFA 4EA4A 3N5NX 4AIAA 1P7MA 4AI4A 1XQOA 1LWWA 1YQMA 1N3AA 2NOIA 1XG7A 4B21A 4B24A 1KG4A 1XQPA 1DIZA 3I0XA 5AN4A 1LWYA 4UOBA 1ORNA 1PU8A 1MPGA 4YOQA 2JHJA 4EW0A 4DK9A 1WEFA 3CVTA 1KG6A 1KO9A 1KG7A 4EVVA 4YPHA 4HSBA 2YG9A 3F0ZA 2NOEA 1RRSA 3CWTA 3KNTA 1KG3A 3FSPA 3G0QA 3CWAA 1KEAA 4PIIA 2JHNA 2JG6A 3FHGA 1KG2A 4E9EA 1FN7A 1KQJA 1WEGA 1EBMA 3CW7A 4E9FA 3CWSA 3OH9A 1PU7A 4YPRA 4EA5A 1MUDA 1LWVA 4E9GA 1YQLA 1M3HA 3CWUA 1LMZA 3S6IA 3OH6A 4E9HA 5CHZA 1WEIA 4EJYA 4EW4A 2NOHA 2NOZA 1NGNA 1HU0A 5KN8A 4UNFA 3OGDA 1N39A 4OFHA 1RRQA 1PU6A 1M3QA 2NOLA 1MUYA 2I5WA 4OFAA 4B22A 4OFEA 2OFKA 1YQRA 1YQKA 5DPKA 3F10A 3CVSA 4AI5A 3KTUA 1PVSA 4B23A 2ABKA 1VRLA 1KG5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3D4V A;  2YG8 A;  2H56 A;  1MUN A;  1ORP A;  1N3C A;  1P59 A;  2XHI A;  3N0U A;  3FHF A;  3IHO A;  3IH7 A;  3I0W A;  5KN9 A;  2NOB A;  1NKU A;  4EJZ A;  2OFI A;  2NOF A;  4EA4 A;  3N5N X;  4AIA A;  1P7M A;  4AI4 A;  1XQO A;  1LWW A;  1YQM A;  1N3A A;  2NOI A;  1XG7 A;  4B21 A;  4B24 A;  1KG4 A;  1XQP A;  1DIZ A;  3I0X A;  5AN4 A;  1LWY A;  4UOB A;  1ORN A;  1PU8 A;  1MPG A;  4YOQ A;  2JHJ A;  4EW0 A;  4DK9 A;  1WEF A;  3CVT A;  1KG6 A;  1KO9 A;  1KG7 A;  4EVV A;  4YPH A;  4HSB A;  2YG9 A;  3F0Z A;  2NOE A;  1RRS A;  3CWT A;  3KNT A;  1KG3 A;  3FSP A;  3G0Q A;  3CWA A;  1KEA A;  4PII A;  2JHN A;  2JG6 A;  3FHG A;  1KG2 A;  4E9E A;  1FN7 A;  1KQJ A;  1WEG A;  1EBM A;  3CW7 A;  4E9F A;  3CWS A;  3OH9 A;  1PU7 A;  4YPR A;  4EA5 A;  1MUD A;  1LWV A;  4E9G A;  1YQL A;  1M3H A;  3CWU A;  1LMZ A;  3S6I A;  3OH6 A;  4E9H A;  5CHZ A;  1WEI A;  4EJY A;  4EW4 A;  2NOH A;  2NOZ A;  1NGN A;  1HU0 A;  5KN8 A;  4UNF A;  3OGD A;  1N39 A;  4OFH A;  1RRQ A;  1PU6 A;  1M3Q A;  2NOL A;  1MUY A;  2I5W A;  4OFA A;  4B22 A;  4OFE A;  2OFK A;  1YQR A;  1YQK A;  5DPK A;  3F10 A;  3CVS A;  4AI5 A;  3KTU A;  1PVS A;  4B23 A;  2ABK A;  1VRL A;  1KG5 A; 
#chains in the Genus database with same CATH topology
 3D4V A;  2YG8 A;  2H56 A;  1MUN A;  1ORP A;  1N3C A;  4BDY A;  1P59 A;  2XHI A;  3L2W A;  3N0U A;  3FHF A;  3R2X C;  3IHO A;  3IH7 A;  4BE0 A;  4E7L A;  3I0W A;  5KN9 A;  3L2R A;  2NOB A;  1NKU A;  2W04 A;  3L2V A;  2V75 A;  4EJZ A;  2OFI A;  2NOF A;  4BE2 A;  4EA4 A;  3N5N X;  4AIA A;  1P7M A;  4AI4 A;  3OS1 A;  1XQO A;  3OYA A;  3OYJ A;  1LWW A;  1YQM A;  1N3A A;  2NOI A;  1XG7 A;  4B21 A;  5FRN A;  3OY9 A;  4B24 A;  1KG4 A;  1XQP A;  1DIZ A;  2W03 A;  4BE1 A;  3OYE A;  3I0X A;  3OS0 A;  3S3M A;  5AN4 A;  1LWY A;  4UOB A;  1ORN A;  1PU8 A;  1MPG A;  4YOQ A;  2JHJ A;  4EW0 A;  4DK9 A;  1WEF A;  3LCN A;  4ZTF A;  3CVT A;  1KG6 A;  1KO9 A;  1KG7 A;  4EVV A;  4YPH A;  3OS2 A;  4HSB A;  2YG9 A;  3F0Z A;  2NOE A;  3OYM A;  4ZTJ A;  1RRS A;  3KNT A;  1U84 A;  3CWT A;  1KG3 A;  3FSP A;  3G0Q A;  3CWA A;  1KEA A;  3VW4 A;  4PII A;  2JHN A;  2JG6 A;  3FHG A;  1KG2 A;  4E9E A;  1FN7 A;  1KQJ A;  1WEG A;  3OYL A;  1EBM A;  3CW7 A;  4E9F A;  4BDZ A;  3CWS A;  3OH9 A;  3OYG A;  4E7K A;  1PU7 A;  4YPR A;  4EA5 A;  1MUD A;  1LWV A;  4E9G A;  5FRO A;  4E7I A;  1YQL A;  1M3H A;  3CWU A;  1LMZ A;  3S6I A;  2JPS A;  3OYD A;  3L2Q A;  3OH6 A;  3S3N A;  4E9H A;  5CHZ A;  1WEI A;  3OYB A;  3OYF A;  3OYH A;  3OYN A;  4EJY A;  3NNQ A;  4EW4 A;  3S3O A;  2NOH A;  2NOZ A;  1NGN A;  1HU0 A;  5KN8 A;  4UNF A;  4BAC A;  3OGD A;  3OYK A;  1N39 A;  4OFH A;  1RRQ A;  4E7J A;  4IKF A;  1PU6 A;  1M3Q A;  2NOL A;  3L2U A;  4NZG A;  3OYI A;  1MUY A;  2I5W A;  4OFA A;  4E7H A;  4B22 A;  3OYC A;  4OFE A;  2OFK A;  1YQR A;  1YQK A;  5DPK A;  3F10 A;  3CVS A;  4AI5 A;  3KTU A;  1PVS A;  5FRM A;  4B23 A;  2ABK A;  1VRL A;  1KG5 A; 
#chains in the Genus database with same CATH homology
 3D4V A;  2YG8 A;  2H56 A;  1MUN A;  1ORP A;  1N3C A;  1P59 A;  2XHI A;  3N0U A;  3FHF A;  3IHO A;  3IH7 A;  3I0W A;  5KN9 A;  2NOB A;  1NKU A;  4EJZ A;  2OFI A;  2NOF A;  4EA4 A;  3N5N X;  4AIA A;  1P7M A;  4AI4 A;  1XQO A;  1LWW A;  1YQM A;  1N3A A;  2NOI A;  1XG7 A;  4B21 A;  4B24 A;  1KG4 A;  1XQP A;  1DIZ A;  3I0X A;  5AN4 A;  1LWY A;  4UOB A;  1ORN A;  1PU8 A;  1MPG A;  4YOQ A;  2JHJ A;  4EW0 A;  4DK9 A;  1WEF A;  3CVT A;  1KG6 A;  1KO9 A;  1KG7 A;  4EVV A;  4YPH A;  4HSB A;  2YG9 A;  3F0Z A;  2NOE A;  1RRS A;  3CWT A;  3KNT A;  1KG3 A;  3FSP A;  3G0Q A;  3CWA A;  1KEA A;  4PII A;  2JHN A;  2JG6 A;  3FHG A;  1KG2 A;  4E9E A;  1FN7 A;  1KQJ A;  1WEG A;  1EBM A;  3CW7 A;  4E9F A;  3CWS A;  3OH9 A;  1PU7 A;  4YPR A;  4EA5 A;  1MUD A;  1LWV A;  4E9G A;  1YQL A;  1M3H A;  3CWU A;  1LMZ A;  3S6I A;  3OH6 A;  4E9H A;  5CHZ A;  1WEI A;  4EJY A;  4EW4 A;  2NOH A;  2NOZ A;  1NGN A;  1HU0 A;  5KN8 A;  4UNF A;  3OGD A;  1N39 A;  4OFH A;  1RRQ A;  1PU6 A;  1M3Q A;  2NOL A;  1MUY A;  2I5W A;  4OFA A;  4B22 A;  4OFE A;  2OFK A;  1YQR A;  1YQK A;  5DPK A;  3F10 A;  3CVS A;  4AI5 A;  3KTU A;  1PVS A;  4B23 A;  2ABK A;  1VRL A;  1KG5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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