4OFEA

Structural basis for thymine glycosylase activity on t:o6-methylg mismatch by methyl-cpg binding domain protein 4: implications for roles of arg468 in mismatch recognition and catalysis
Total Genus 51
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
51
sequence length
142
structure length
142
Chain Sequence
WTPPRSPFNLVQETLFHDPWKLLIATIFLNKTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPENHKLNKYHDWLWENHEKLSL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Methyl-CpG-binding domain protein 4
publication title Structure of R468K/D560N MBD4 bound to G:T mispair DNA
rcsb
source organism Homo sapiens
molecule tags Hydrolase/dna
total genus 51
structure length 142
sequence length 142
ec nomenclature ec 3.2.2.-:
pdb deposition date 2014-01-14
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4ofeA00
3CWTA 1KQJA 2NOZA 2JHJA 5AN4A 4EJYA 1M3QA 4EA4A 4YOQA 4DK9A 4YPHA 5DPKA 3N0UA 1MUYA 2H56A 3D4VA 1WEGA 2I5WA 1KO9A 3CWAA 4EVVA 1PU6A 4E9EA 1KG3A 3N5NX 1N3CA 4B21A 1KG6A 1NGNA 3F10A 1YQLA 1HU0A 3CWSA 3KTUA 1RRQA 1MPGA 1PVSA 1LWVA 1VRLA 1YQRA 2NOLA 4EJZA 1XQOA 3CVSA 4EA5A 5KN8A 1ORNA 2YG8A 3CWUA 1P59A 5CHZA 2ABKA 4HSBA 4B22A 1N39A 3KNTA 2OFKA 4B24A 4AI5A 4UNFA 2JG6A 1LMZA 1ORPA 1M3HA 1PU8A 3IHOA 3IH7A 1WEFA 1NKUA 3I0XA 1KEAA 2YG9A 3S6IA 3G0QA 3FHFA 4B23A 4UOBA 4EW4A 4YPRA 2OFIA 1MUNA 1EBMA 1KG5A 2XHIA 1FN7A 4OFEA 4E9GA 3FSPA 1PU7A 4EW0A 1KG4A 1N3AA 1KG7A 3OH9A 4PIIA 1MUDA 1KG2A 2NOIA 1LWWA 3OH6A 2NOBA 2NOHA 1XQPA 3CW7A 3I0WA 4OFAA 1LWYA 3CVTA 4AI4A 5KN9A 1YQMA 1XG7A 3F0ZA 4E9FA 1RRSA 1P7MA 4AIAA 4E9HA 2NOFA 1DIZA 1YQKA 2NOEA 4OFHA 3FHGA 1WEIA 2JHNA 3OGDA
chains in the Genus database with same CATH superfamily
3CWTA 1KQJA 3L2RA 2JHJA 2NOZA 3OYCA 5AN4A 3OS0A 3L2VA 4EJYA 1M3QA 3OYEA 4EA4A 4YOQA 4DK9A 4BDYA 4YPHA 5DPKA 3N0UA 3OS2A 1MUYA 2H56A 3OYBA 3D4VA 1WEGA 5FRMA 4E7KA 1KO9A 3CWAA 2I5WA 4EVVA 1PU6A 4E7IA 3R2XC 4E9EA 4E7LA 4BE2A 2W03A 1KG3A 3N5NX 1N3CA 1KG6A 4B21A 1NGNA 3F10A 1YQLA 1HU0A 3CWSA 3KTUA 1RRQA 1MPGA 3OYLA 1PVSA 1LWVA 1VRLA 2W04A 1YQRA 4EJZA 2NOLA 3OYNA 1XQOA 3CVSA 3NNQA 4EA5A 5KN8A 4ZTJA 1ORNA 2YG8A 3CWUA 3OYDA 1P59A 5CHZA 2ABKA 4HSBA 4B22A 1N39A 3KNTA 2OFKA 4B24A 4AI5A 4UNFA 2JG6A 3OYIA 3L2WA 1LMZA 1ORPA 1M3HA 1PU8A 3IHOA 3VW4A 3IH7A 1WEFA 2V75A 1NKUA 3I0XA 1KEAA 4ZTFA 2YG9A 4BDZA 3S6IA 3G0QA 3FHFA 4B23A 4UOBA 4NZGA 4EW4A 4YPRA 2OFIA 1MUNA 1EBMA 1KG5A 3OYAA 3OYGA 3L2QA 2XHIA 4BE1A 5FRNA 1FN7A 3OYFA 4OFEA 4E9GA 3FSPA 1PU7A 4EW0A 3S3OA 1KG4A 4E7JA 1U84A 1N3AA 3OY9A 1KG7A 3OYHA 3OH9A 4PIIA 1MUDA 1KG2A 2NOIA 4IKFA 1LWWA 3OH6A 3OS1A 2NOBA 2NOHA 4E7HA 5FROA 3OYKA 1XQPA 3CW7A 3I0WA 4OFAA 3LCNA 1LWYA 3OYMA 4BE0A 3CVTA 4AI4A 5KN9A 4BACA 1YQMA 1XG7A 2JPSA 3F0ZA 4E9FA 1RRSA 1P7MA 3OYJA 4AIAA 3S3MA 4E9HA 2NOFA 1DIZA 1YQKA 2NOEA 3L2UA 4OFHA 3S3NA 3FHGA 1WEIA 2JHNA 3OGDA
chains in the Genus database with same CATH topology
3CWTA 1KQJA 2NOZA 2JHJA 5AN4A 4EJYA 1M3QA 4EA4A 4YOQA 4DK9A 4YPHA 5DPKA 3N0UA 1MUYA 2H56A 3D4VA 1WEGA 2I5WA 1KO9A 3CWAA 4EVVA 1PU6A 4E9EA 1KG3A 3N5NX 1N3CA 4B21A 1KG6A 1NGNA 3F10A 1YQLA 1HU0A 3CWSA 3KTUA 1RRQA 1MPGA 1PVSA 1LWVA 1VRLA 1YQRA 2NOLA 4EJZA 1XQOA 3CVSA 4EA5A 5KN8A 1ORNA 2YG8A 3CWUA 1P59A 5CHZA 2ABKA 4HSBA 4B22A 1N39A 3KNTA 2OFKA 4B24A 4AI5A 4UNFA 2JG6A 1LMZA 1ORPA 1M3HA 1PU8A 3IHOA 3IH7A 1WEFA 1NKUA 3I0XA 1KEAA 2YG9A 3S6IA 3G0QA 3FHFA 4B23A 4UOBA 4EW4A 4YPRA 2OFIA 1MUNA 1EBMA 1KG5A 2XHIA 1FN7A 4OFEA 4E9GA 3FSPA 1PU7A 4EW0A 1KG4A 1N3AA 1KG7A 3OH9A 4PIIA 1MUDA 1KG2A 2NOIA 1LWWA 3OH6A 2NOBA 2NOHA 1XQPA 3CW7A 3I0WA 4OFAA 1LWYA 3CVTA 4AI4A 5KN9A 1YQMA 1XG7A 3F0ZA 4E9FA 1RRSA 1P7MA 4AIAA 4E9HA 2NOFA 1DIZA 1YQKA 2NOEA 4OFHA 3FHGA 1WEIA 2JHNA 3OGDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CWT A;  1KQJ A;  2NOZ A;  2JHJ A;  5AN4 A;  4EJY A;  1M3Q A;  4EA4 A;  4YOQ A;  4DK9 A;  4YPH A;  5DPK A;  3N0U A;  1MUY A;  2H56 A;  3D4V A;  1WEG A;  2I5W A;  1KO9 A;  3CWA A;  4EVV A;  1PU6 A;  4E9E A;  1KG3 A;  3N5N X;  1N3C A;  4B21 A;  1KG6 A;  1NGN A;  3F10 A;  1YQL A;  1HU0 A;  3CWS A;  3KTU A;  1RRQ A;  1MPG A;  1PVS A;  1LWV A;  1VRL A;  1YQR A;  2NOL A;  4EJZ A;  1XQO A;  3CVS A;  4EA5 A;  5KN8 A;  1ORN A;  2YG8 A;  3CWU A;  1P59 A;  5CHZ A;  2ABK A;  4HSB A;  4B22 A;  1N39 A;  3KNT A;  2OFK A;  4B24 A;  4AI5 A;  4UNF A;  2JG6 A;  1LMZ A;  1ORP A;  1M3H A;  1PU8 A;  3IHO A;  3IH7 A;  1WEF A;  1NKU A;  3I0X A;  1KEA A;  2YG9 A;  3S6I A;  3G0Q A;  3FHF A;  4B23 A;  4UOB A;  4EW4 A;  4YPR A;  2OFI A;  1MUN A;  1EBM A;  1KG5 A;  2XHI A;  1FN7 A;  4OFE A;  4E9G A;  3FSP A;  1PU7 A;  4EW0 A;  1KG4 A;  1N3A A;  1KG7 A;  3OH9 A;  4PII A;  1MUD A;  1KG2 A;  2NOI A;  1LWW A;  3OH6 A;  2NOB A;  2NOH A;  1XQP A;  3CW7 A;  3I0W A;  4OFA A;  1LWY A;  3CVT A;  4AI4 A;  5KN9 A;  1YQM A;  1XG7 A;  3F0Z A;  4E9F A;  1RRS A;  1P7M A;  4AIA A;  4E9H A;  2NOF A;  1DIZ A;  1YQK A;  2NOE A;  4OFH A;  3FHG A;  1WEI A;  2JHN A;  3OGD A; 
#chains in the Genus database with same CATH topology
 3CWT A;  1KQJ A;  3L2R A;  2JHJ A;  2NOZ A;  3OYC A;  5AN4 A;  3OS0 A;  3L2V A;  4EJY A;  1M3Q A;  3OYE A;  4EA4 A;  4YOQ A;  4DK9 A;  4BDY A;  4YPH A;  5DPK A;  3N0U A;  3OS2 A;  1MUY A;  2H56 A;  3OYB A;  3D4V A;  1WEG A;  5FRM A;  4E7K A;  1KO9 A;  3CWA A;  2I5W A;  4EVV A;  1PU6 A;  4E7I A;  3R2X C;  4E9E A;  4E7L A;  4BE2 A;  2W03 A;  1KG3 A;  3N5N X;  1N3C A;  1KG6 A;  4B21 A;  1NGN A;  3F10 A;  1YQL A;  1HU0 A;  3CWS A;  3KTU A;  1RRQ A;  1MPG A;  3OYL A;  1PVS A;  1LWV A;  1VRL A;  2W04 A;  1YQR A;  4EJZ A;  2NOL A;  3OYN A;  1XQO A;  3CVS A;  3NNQ A;  4EA5 A;  5KN8 A;  4ZTJ A;  1ORN A;  2YG8 A;  3CWU A;  3OYD A;  1P59 A;  5CHZ A;  2ABK A;  4HSB A;  4B22 A;  1N39 A;  3KNT A;  2OFK A;  4B24 A;  4AI5 A;  4UNF A;  2JG6 A;  3OYI A;  3L2W A;  1LMZ A;  1ORP A;  1M3H A;  1PU8 A;  3IHO A;  3VW4 A;  3IH7 A;  1WEF A;  2V75 A;  1NKU A;  3I0X A;  1KEA A;  4ZTF A;  2YG9 A;  4BDZ A;  3S6I A;  3G0Q A;  3FHF A;  4B23 A;  4UOB A;  4NZG A;  4EW4 A;  4YPR A;  2OFI A;  1MUN A;  1EBM A;  1KG5 A;  3OYA A;  3OYG A;  3L2Q A;  2XHI A;  4BE1 A;  5FRN A;  1FN7 A;  3OYF A;  4OFE A;  4E9G A;  3FSP A;  1PU7 A;  4EW0 A;  3S3O A;  1KG4 A;  4E7J A;  1U84 A;  1N3A A;  3OY9 A;  1KG7 A;  3OYH A;  3OH9 A;  4PII A;  1MUD A;  1KG2 A;  2NOI A;  4IKF A;  1LWW A;  3OH6 A;  3OS1 A;  2NOB A;  2NOH A;  4E7H A;  5FRO A;  3OYK A;  1XQP A;  3CW7 A;  3I0W A;  4OFA A;  3LCN A;  1LWY A;  3OYM A;  4BE0 A;  3CVT A;  4AI4 A;  5KN9 A;  4BAC A;  1YQM A;  1XG7 A;  2JPS A;  3F0Z A;  4E9F A;  1RRS A;  1P7M A;  3OYJ A;  4AIA A;  3S3M A;  4E9H A;  2NOF A;  1DIZ A;  1YQK A;  2NOE A;  3L2U A;  4OFH A;  3S3N A;  3FHG A;  1WEI A;  2JHN A;  3OGD A; 
#chains in the Genus database with same CATH homology
 3CWT A;  1KQJ A;  2NOZ A;  2JHJ A;  5AN4 A;  4EJY A;  1M3Q A;  4EA4 A;  4YOQ A;  4DK9 A;  4YPH A;  5DPK A;  3N0U A;  1MUY A;  2H56 A;  3D4V A;  1WEG A;  2I5W A;  1KO9 A;  3CWA A;  4EVV A;  1PU6 A;  4E9E A;  1KG3 A;  3N5N X;  1N3C A;  4B21 A;  1KG6 A;  1NGN A;  3F10 A;  1YQL A;  1HU0 A;  3CWS A;  3KTU A;  1RRQ A;  1MPG A;  1PVS A;  1LWV A;  1VRL A;  1YQR A;  2NOL A;  4EJZ A;  1XQO A;  3CVS A;  4EA5 A;  5KN8 A;  1ORN A;  2YG8 A;  3CWU A;  1P59 A;  5CHZ A;  2ABK A;  4HSB A;  4B22 A;  1N39 A;  3KNT A;  2OFK A;  4B24 A;  4AI5 A;  4UNF A;  2JG6 A;  1LMZ A;  1ORP A;  1M3H A;  1PU8 A;  3IHO A;  3IH7 A;  1WEF A;  1NKU A;  3I0X A;  1KEA A;  2YG9 A;  3S6I A;  3G0Q A;  3FHF A;  4B23 A;  4UOB A;  4EW4 A;  4YPR A;  2OFI A;  1MUN A;  1EBM A;  1KG5 A;  2XHI A;  1FN7 A;  4OFE A;  4E9G A;  3FSP A;  1PU7 A;  4EW0 A;  1KG4 A;  1N3A A;  1KG7 A;  3OH9 A;  4PII A;  1MUD A;  1KG2 A;  2NOI A;  1LWW A;  3OH6 A;  2NOB A;  2NOH A;  1XQP A;  3CW7 A;  3I0W A;  4OFA A;  1LWY A;  3CVT A;  4AI4 A;  5KN9 A;  1YQM A;  1XG7 A;  3F0Z A;  4E9F A;  1RRS A;  1P7M A;  4AIA A;  4E9H A;  2NOF A;  1DIZ A;  1YQK A;  2NOE A;  4OFH A;  3FHG A;  1WEI A;  2JHN A;  3OGD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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