4E9FA

Structure of the glycosylase domain of mbd4 bound to ap site containing dna
Total Genus 46
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
46
sequence length
138
structure length
138
Chain Sequence
KWTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEDHKLNKYHDWLWENH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.
pubmed doi rcsb
molecule tags Hydrolase/dna
source organism Homo sapiens
molecule keywords Methyl-CpG-binding domain protein 4
total genus 46
structure length 138
sequence length 138
ec nomenclature ec 3.2.2.-:
pdb deposition date 2012-03-21
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4e9fA00
3S6IA 1NKUA 3G0QA 1KG5A 4EVVA 1M3HA 1LWWA 1KG2A 3I0XA 1LWYA 3KTUA 1KG3A 2NOHA 5AN4A 2YG8A 3FHFA 3D4VA 3N5NX 3CWSA 1YQRA 2NOFA 3CVSA 3IH7A 5DPKA 1XQPA 3N0UA 4AIAA 1P59A 4UOBA 2JHNA 4EA4A 1N3CA 1YQLA 4HSBA 1M3QA 2JHJA 2H56A 1VRLA 5KN8A 1N39A 2NOLA 3F0ZA 2NOIA 1PU7A 4B24A 2ABKA 3FHGA 1MUDA 3CW7A 1WEIA 1P7MA 4E9FA 1LWVA 4DK9A 4OFEA 1KG7A 4YPHA 2NOBA 1KG4A 4B21A 4AI5A 4EW0A 1KQJA 1KEAA 1DIZA 2NOEA 4PIIA 4EW4A 4EJZA 4E9EA 4EA5A 5KN9A 3CWAA 1XQOA 3FSPA 1MPGA 1WEGA 3CWUA 3CWTA 4YPRA 3CVTA 4E9HA 1ORNA 3OH6A 4OFHA 1XG7A 1YQKA 4YOQA 1NGNA 1YQMA 1RRQA 4E9GA 1EBMA 2XHIA 1LMZA 1PVSA 1MUNA 2OFKA 1RRSA 1ORPA 1PU6A 1N3AA 4B22A 3IHOA 2I5WA 1WEFA 2NOZA 4AI4A 1PU8A 2JG6A 3F10A 4EJYA 1HU0A 1FN7A 4OFAA 3KNTA 2YG9A 1KG6A 3OGDA 3OH9A 2OFIA 4B23A 4UNFA 5CHZA 1MUYA 3I0WA 1KO9A
chains in the Genus database with same CATH superfamily
3OYAA 3S6IA 1NKUA 3G0QA 1KG5A 4EVVA 1M3HA 1LWWA 1KG2A 3I0XA 1LWYA 3OYKA 3KTUA 3OYBA 1KG3A 2NOHA 5FRNA 5AN4A 3L2QA 2YG8A 3OYIA 3FHFA 3D4VA 3N5NX 3CWSA 1YQRA 3OY9A 2NOFA 3CVSA 3IH7A 5DPKA 1XQPA 3N0UA 5FROA 4AIAA 1P59A 4UOBA 2JHNA 4EA4A 1N3CA 1YQLA 4HSBA 1M3QA 2JHJA 2H56A 1VRLA 5KN8A 1N39A 2NOLA 3F0ZA 2NOIA 3L2UA 1PU7A 1U84A 3R2XC 4E7KA 4B24A 3OS2A 2ABKA 3FHGA 1MUDA 3CW7A 1WEIA 1P7MA 4E9FA 4BE0A 1LWVA 3OYHA 4DK9A 4OFEA 4IKFA 3OYNA 5FRMA 1KG7A 4YPHA 2NOBA 1KG4A 4B21A 3OS0A 4E7LA 3OYDA 3LCNA 4AI5A 3OYLA 3L2VA 3NNQA 1KQJA 4EW0A 1KEAA 1DIZA 3OYJA 2NOEA 4PIIA 2JPSA 4EW4A 4EJZA 4E9EA 4EA5A 5KN9A 3CWAA 3S3NA 3OYEA 3OYGA 1XQOA 3FSPA 1MPGA 1WEGA 3CWUA 3CWTA 4YPRA 2W04A 3CVTA 4E9HA 1ORNA 4NZGA 3OH6A 4OFHA 4BE2A 1XG7A 3OYMA 1YQKA 3S3MA 4YOQA 1NGNA 3OS1A 1YQMA 4ZTFA 1RRQA 4E9GA 1EBMA 2XHIA 4E7IA 1LMZA 1PVSA 1MUNA 2OFKA 1RRSA 1ORPA 3VW4A 1PU6A 1N3AA 4B22A 3S3OA 4BDZA 3OYCA 3IHOA 2I5WA 1WEFA 2W03A 2NOZA 4AI4A 1PU8A 4BDYA 2JG6A 3F10A 4EJYA 1HU0A 3L2RA 4ZTJA 1FN7A 4OFAA 3KNTA 2YG9A 1KG6A 3OGDA 3OH9A 2OFIA 4B23A 4BACA 4UNFA 4E7JA 3OYFA 3L2WA 5CHZA 4BE1A 1MUYA 3I0WA 4E7HA 1KO9A 2V75A
chains in the Genus database with same CATH topology
3S6IA 1NKUA 3G0QA 1KG5A 4EVVA 1M3HA 1LWWA 1KG2A 3I0XA 1LWYA 3KTUA 1KG3A 2NOHA 5AN4A 2YG8A 3FHFA 3D4VA 3N5NX 3CWSA 1YQRA 2NOFA 3CVSA 3IH7A 5DPKA 1XQPA 3N0UA 4AIAA 1P59A 4UOBA 2JHNA 4EA4A 1N3CA 1YQLA 4HSBA 1M3QA 2JHJA 2H56A 1VRLA 5KN8A 1N39A 2NOLA 3F0ZA 2NOIA 1PU7A 4B24A 2ABKA 3FHGA 1MUDA 3CW7A 1WEIA 1P7MA 4E9FA 1LWVA 4DK9A 4OFEA 1KG7A 4YPHA 2NOBA 1KG4A 4B21A 4AI5A 4EW0A 1KQJA 1KEAA 1DIZA 2NOEA 4PIIA 4EW4A 4EJZA 4E9EA 4EA5A 5KN9A 3CWAA 1XQOA 3FSPA 1MPGA 1WEGA 3CWUA 3CWTA 4YPRA 3CVTA 4E9HA 1ORNA 3OH6A 4OFHA 1XG7A 1YQKA 4YOQA 1NGNA 1YQMA 1RRQA 4E9GA 1EBMA 2XHIA 1LMZA 1PVSA 1MUNA 2OFKA 1RRSA 1ORPA 1PU6A 1N3AA 4B22A 3IHOA 2I5WA 1WEFA 2NOZA 4AI4A 1PU8A 2JG6A 3F10A 4EJYA 1HU0A 1FN7A 4OFAA 3KNTA 2YG9A 1KG6A 3OGDA 3OH9A 2OFIA 4B23A 4UNFA 5CHZA 1MUYA 3I0WA 1KO9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3S6I A;  1NKU A;  3G0Q A;  1KG5 A;  4EVV A;  1M3H A;  1LWW A;  1KG2 A;  3I0X A;  1LWY A;  3KTU A;  1KG3 A;  2NOH A;  5AN4 A;  2YG8 A;  3FHF A;  3D4V A;  3N5N X;  3CWS A;  1YQR A;  2NOF A;  3CVS A;  3IH7 A;  5DPK A;  1XQP A;  3N0U A;  4AIA A;  1P59 A;  4UOB A;  2JHN A;  4EA4 A;  1N3C A;  1YQL A;  4HSB A;  1M3Q A;  2JHJ A;  2H56 A;  1VRL A;  5KN8 A;  1N39 A;  2NOL A;  3F0Z A;  2NOI A;  1PU7 A;  4B24 A;  2ABK A;  3FHG A;  1MUD A;  3CW7 A;  1WEI A;  1P7M A;  4E9F A;  1LWV A;  4DK9 A;  4OFE A;  1KG7 A;  4YPH A;  2NOB A;  1KG4 A;  4B21 A;  4AI5 A;  4EW0 A;  1KQJ A;  1KEA A;  1DIZ A;  2NOE A;  4PII A;  4EW4 A;  4EJZ A;  4E9E A;  4EA5 A;  5KN9 A;  3CWA A;  1XQO A;  3FSP A;  1MPG A;  1WEG A;  3CWU A;  3CWT A;  4YPR A;  3CVT A;  4E9H A;  1ORN A;  3OH6 A;  4OFH A;  1XG7 A;  1YQK A;  4YOQ A;  1NGN A;  1YQM A;  1RRQ A;  4E9G A;  1EBM A;  2XHI A;  1LMZ A;  1PVS A;  1MUN A;  2OFK A;  1RRS A;  1ORP A;  1PU6 A;  1N3A A;  4B22 A;  3IHO A;  2I5W A;  1WEF A;  2NOZ A;  4AI4 A;  1PU8 A;  2JG6 A;  3F10 A;  4EJY A;  1HU0 A;  1FN7 A;  4OFA A;  3KNT A;  2YG9 A;  1KG6 A;  3OGD A;  3OH9 A;  2OFI A;  4B23 A;  4UNF A;  5CHZ A;  1MUY A;  3I0W A;  1KO9 A; 
#chains in the Genus database with same CATH topology
 3OYA A;  3S6I A;  1NKU A;  3G0Q A;  1KG5 A;  4EVV A;  1M3H A;  1LWW A;  1KG2 A;  3I0X A;  1LWY A;  3OYK A;  3KTU A;  3OYB A;  1KG3 A;  2NOH A;  5FRN A;  5AN4 A;  3L2Q A;  2YG8 A;  3OYI A;  3FHF A;  3D4V A;  3N5N X;  3CWS A;  1YQR A;  3OY9 A;  2NOF A;  3CVS A;  3IH7 A;  5DPK A;  1XQP A;  3N0U A;  5FRO A;  4AIA A;  1P59 A;  4UOB A;  2JHN A;  4EA4 A;  1N3C A;  1YQL A;  4HSB A;  1M3Q A;  2JHJ A;  2H56 A;  1VRL A;  5KN8 A;  1N39 A;  2NOL A;  3F0Z A;  2NOI A;  3L2U A;  1PU7 A;  1U84 A;  3R2X C;  4E7K A;  4B24 A;  3OS2 A;  2ABK A;  3FHG A;  1MUD A;  3CW7 A;  1WEI A;  1P7M A;  4E9F A;  4BE0 A;  1LWV A;  3OYH A;  4DK9 A;  4OFE A;  4IKF A;  3OYN A;  5FRM A;  1KG7 A;  4YPH A;  2NOB A;  1KG4 A;  4B21 A;  3OS0 A;  4E7L A;  3OYD A;  3LCN A;  4AI5 A;  3OYL A;  3L2V A;  3NNQ A;  1KQJ A;  4EW0 A;  1KEA A;  1DIZ A;  3OYJ A;  2NOE A;  4PII A;  2JPS A;  4EW4 A;  4EJZ A;  4E9E A;  4EA5 A;  5KN9 A;  3CWA A;  3S3N A;  3OYE A;  3OYG A;  1XQO A;  3FSP A;  1MPG A;  1WEG A;  3CWU A;  3CWT A;  4YPR A;  2W04 A;  3CVT A;  4E9H A;  1ORN A;  4NZG A;  3OH6 A;  4OFH A;  4BE2 A;  1XG7 A;  3OYM A;  1YQK A;  3S3M A;  4YOQ A;  1NGN A;  3OS1 A;  1YQM A;  4ZTF A;  1RRQ A;  4E9G A;  1EBM A;  2XHI A;  4E7I A;  1LMZ A;  1PVS A;  1MUN A;  2OFK A;  1RRS A;  1ORP A;  3VW4 A;  1PU6 A;  1N3A A;  4B22 A;  3S3O A;  4BDZ A;  3OYC A;  3IHO A;  2I5W A;  1WEF A;  2W03 A;  2NOZ A;  4AI4 A;  1PU8 A;  4BDY A;  2JG6 A;  3F10 A;  4EJY A;  1HU0 A;  3L2R A;  4ZTJ A;  1FN7 A;  4OFA A;  3KNT A;  2YG9 A;  1KG6 A;  3OGD A;  3OH9 A;  2OFI A;  4B23 A;  4BAC A;  4UNF A;  4E7J A;  3OYF A;  3L2W A;  5CHZ A;  4BE1 A;  1MUY A;  3I0W A;  4E7H A;  1KO9 A;  2V75 A; 
#chains in the Genus database with same CATH homology
 3S6I A;  1NKU A;  3G0Q A;  1KG5 A;  4EVV A;  1M3H A;  1LWW A;  1KG2 A;  3I0X A;  1LWY A;  3KTU A;  1KG3 A;  2NOH A;  5AN4 A;  2YG8 A;  3FHF A;  3D4V A;  3N5N X;  3CWS A;  1YQR A;  2NOF A;  3CVS A;  3IH7 A;  5DPK A;  1XQP A;  3N0U A;  4AIA A;  1P59 A;  4UOB A;  2JHN A;  4EA4 A;  1N3C A;  1YQL A;  4HSB A;  1M3Q A;  2JHJ A;  2H56 A;  1VRL A;  5KN8 A;  1N39 A;  2NOL A;  3F0Z A;  2NOI A;  1PU7 A;  4B24 A;  2ABK A;  3FHG A;  1MUD A;  3CW7 A;  1WEI A;  1P7M A;  4E9F A;  1LWV A;  4DK9 A;  4OFE A;  1KG7 A;  4YPH A;  2NOB A;  1KG4 A;  4B21 A;  4AI5 A;  4EW0 A;  1KQJ A;  1KEA A;  1DIZ A;  2NOE A;  4PII A;  4EW4 A;  4EJZ A;  4E9E A;  4EA5 A;  5KN9 A;  3CWA A;  1XQO A;  3FSP A;  1MPG A;  1WEG A;  3CWU A;  3CWT A;  4YPR A;  3CVT A;  4E9H A;  1ORN A;  3OH6 A;  4OFH A;  1XG7 A;  1YQK A;  4YOQ A;  1NGN A;  1YQM A;  1RRQ A;  4E9G A;  1EBM A;  2XHI A;  1LMZ A;  1PVS A;  1MUN A;  2OFK A;  1RRS A;  1ORP A;  1PU6 A;  1N3A A;  4B22 A;  3IHO A;  2I5W A;  1WEF A;  2NOZ A;  4AI4 A;  1PU8 A;  2JG6 A;  3F10 A;  4EJY A;  1HU0 A;  1FN7 A;  4OFA A;  3KNT A;  2YG9 A;  1KG6 A;  3OGD A;  3OH9 A;  2OFI A;  4B23 A;  4UNF A;  5CHZ A;  1MUY A;  3I0W A;  1KO9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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