4E9GA

Structure of the glycosylase domain of mbd4 bound to thymine containing dna
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
138
structure length
138
Chain Sequence
WTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEAHKLNKYHDWLWENHE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.
pubmed doi rcsb
molecule tags Hydrolase/dna
source organism Homo sapiens
molecule keywords Methyl-CpG-binding domain protein 4
total genus 43
structure length 138
sequence length 138
ec nomenclature ec 3.2.2.-:
pdb deposition date 2012-03-21
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4e9gA00
1KG6A 5DPKA 3CWUA 3IH7A 1KG7A 4OFAA 3CW7A 3FSPA 3D4VA 2I5WA 2NOEA 3FHFA 3IHOA 1N3CA 3CWTA 3I0XA 1YQLA 4EW4A 4AI4A 1DIZA 1EBMA 1LWYA 1WEIA 1PVSA 4PIIA 1PU6A 1KG3A 4OFHA 1NKUA 2OFKA 2ABKA 4EJZA 1YQMA 3FHGA 2NOIA 1LMZA 4B24A 1XQOA 3G0QA 3CVTA 4DK9A 1KQJA 1HU0A 4UOBA 1ORPA 1ORNA 1FN7A 2NOFA 2H56A 4EJYA 1MUYA 2NOBA 1N3AA 1KG2A 4YPHA 5CHZA 4E9FA 1PU7A 4E9HA 3I0WA 1PU8A 4EA4A 4B22A 2JHNA 1WEFA 3CVSA 1VRLA 1NGNA 1KO9A 1LWVA 2NOHA 1XG7A 1YQKA 1P59A 4EVVA 5KN9A 3CWAA 2JG6A 1N39A 4E9EA 1MUNA 1YQRA 4OFEA 1M3QA 3OGDA 5AN4A 4E9GA 1M3HA 3S6IA 2NOLA 4AIAA 3KTUA 3KNTA 4B23A 3F0ZA 2XHIA 1KG5A 1MPGA 1P7MA 5KN8A 1LWWA 2JHJA 1RRSA 3N0UA 1RRQA 2YG8A 3F10A 3OH9A 1KEAA 3N5NX 4UNFA 2OFIA 4YPRA 2NOZA 1WEGA 1MUDA 1XQPA 4AI5A 4EA5A 3CWSA 1KG4A 4HSBA 4YOQA 2YG9A 3OH6A 4EW0A 4B21A
chains in the Genus database with same CATH superfamily
1KG6A 5DPKA 3CWUA 3IH7A 1KG7A 4OFAA 3CW7A 3FSPA 3D4VA 3OY9A 2I5WA 2NOEA 2W04A 3FHFA 4BE2A 3IHOA 1N3CA 3CWTA 3I0XA 1YQLA 4EW0A 4EW4A 4BDZA 4AI4A 4ZTFA 4BE1A 1DIZA 1EBMA 1LWYA 1WEIA 1PVSA 4PIIA 1PU6A 1KG3A 3NNQA 4OFHA 1NKUA 2OFKA 2ABKA 3L2RA 5FRNA 3OH6A 4EJZA 1YQMA 3FHGA 3OS0A 2NOIA 3OYDA 1LMZA 4B24A 1XQOA 3G0QA 3CVTA 4DK9A 1KQJA 1HU0A 4UOBA 1ORPA 5FROA 1ORNA 3L2VA 1FN7A 4BACA 2NOFA 2H56A 3S3NA 1MUYA 4EJYA 2NOBA 1N3AA 1KG2A 4YPHA 5CHZA 3OYJA 4BE0A 4E9FA 1PU7A 3OYBA 3OYLA 4BDYA 3OYCA 3I0WA 4E9HA 1PU8A 3VW4A 4EA4A 3OYHA 4B22A 4IKFA 2JHNA 1WEFA 3OYNA 3CVSA 1VRLA 1NGNA 1KO9A 1LWVA 2NOHA 1XG7A 3OYFA 1YQKA 1P59A 4EVVA 5KN9A 3CWAA 2JG6A 2JPSA 3OYAA 1N39A 4E9EA 3OYKA 1MUNA 1YQRA 4OFEA 4E7KA 1M3QA 3OYGA 3OGDA 5AN4A 4E9GA 4E7IA 1M3HA 3S6IA 2NOLA 4E7JA 4AIAA 3KTUA 3KNTA 2V75A 1U84A 3S3MA 3L2UA 4B23A 5FRMA 3F0ZA 2XHIA 1KG5A 1MPGA 3L2WA 1P7MA 5KN8A 1LWWA 2JHJA 1RRSA 3N0UA 1RRQA 3OYMA 2YG8A 4NZGA 3R2XC 3F10A 4ZTJA 3OH9A 1KEAA 3N5NX 4UNFA 3OYEA 4YPRA 3L2QA 4E7LA 2OFIA 2NOZA 1WEGA 1MUDA 3OYIA 1XQPA 4AI5A 4EA5A 3CWSA 3LCNA 4E7HA 3S3OA 1KG4A 4HSBA 4YOQA 2W03A 2YG9A 3OS2A 3OS1A 4B21A
chains in the Genus database with same CATH topology
1KG6A 5DPKA 3CWUA 3IH7A 1KG7A 4OFAA 3CW7A 3FSPA 3D4VA 2I5WA 2NOEA 3FHFA 3IHOA 1N3CA 3CWTA 3I0XA 1YQLA 4EW4A 4AI4A 1DIZA 1EBMA 1LWYA 1WEIA 1PVSA 4PIIA 1PU6A 1KG3A 4OFHA 1NKUA 2OFKA 2ABKA 4EJZA 1YQMA 3FHGA 2NOIA 1LMZA 4B24A 1XQOA 3G0QA 3CVTA 4DK9A 1KQJA 1HU0A 4UOBA 1ORPA 1ORNA 1FN7A 2NOFA 2H56A 4EJYA 1MUYA 2NOBA 1N3AA 1KG2A 4YPHA 5CHZA 4E9FA 1PU7A 4E9HA 3I0WA 1PU8A 4EA4A 4B22A 2JHNA 1WEFA 3CVSA 1VRLA 1NGNA 1KO9A 1LWVA 2NOHA 1XG7A 1YQKA 1P59A 4EVVA 5KN9A 3CWAA 2JG6A 1N39A 4E9EA 1MUNA 1YQRA 4OFEA 1M3QA 3OGDA 5AN4A 4E9GA 1M3HA 3S6IA 2NOLA 4AIAA 3KTUA 3KNTA 4B23A 3F0ZA 2XHIA 1KG5A 1MPGA 1P7MA 5KN8A 1LWWA 2JHJA 1RRSA 3N0UA 1RRQA 2YG8A 3F10A 3OH9A 1KEAA 3N5NX 4UNFA 2OFIA 4YPRA 2NOZA 1WEGA 1MUDA 1XQPA 4AI5A 4EA5A 3CWSA 1KG4A 4HSBA 4YOQA 2YG9A 3OH6A 4EW0A 4B21A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KG6 A;  5DPK A;  3CWU A;  3IH7 A;  1KG7 A;  4OFA A;  3CW7 A;  3FSP A;  3D4V A;  2I5W A;  2NOE A;  3FHF A;  3IHO A;  1N3C A;  3CWT A;  3I0X A;  1YQL A;  4EW4 A;  4AI4 A;  1DIZ A;  1EBM A;  1LWY A;  1WEI A;  1PVS A;  4PII A;  1PU6 A;  1KG3 A;  4OFH A;  1NKU A;  2OFK A;  2ABK A;  4EJZ A;  1YQM A;  3FHG A;  2NOI A;  1LMZ A;  4B24 A;  1XQO A;  3G0Q A;  3CVT A;  4DK9 A;  1KQJ A;  1HU0 A;  4UOB A;  1ORP A;  1ORN A;  1FN7 A;  2NOF A;  2H56 A;  4EJY A;  1MUY A;  2NOB A;  1N3A A;  1KG2 A;  4YPH A;  5CHZ A;  4E9F A;  1PU7 A;  4E9H A;  3I0W A;  1PU8 A;  4EA4 A;  4B22 A;  2JHN A;  1WEF A;  3CVS A;  1VRL A;  1NGN A;  1KO9 A;  1LWV A;  2NOH A;  1XG7 A;  1YQK A;  1P59 A;  4EVV A;  5KN9 A;  3CWA A;  2JG6 A;  1N39 A;  4E9E A;  1MUN A;  1YQR A;  4OFE A;  1M3Q A;  3OGD A;  5AN4 A;  4E9G A;  1M3H A;  3S6I A;  2NOL A;  4AIA A;  3KTU A;  3KNT A;  4B23 A;  3F0Z A;  2XHI A;  1KG5 A;  1MPG A;  1P7M A;  5KN8 A;  1LWW A;  2JHJ A;  1RRS A;  3N0U A;  1RRQ A;  2YG8 A;  3F10 A;  3OH9 A;  1KEA A;  3N5N X;  4UNF A;  2OFI A;  4YPR A;  2NOZ A;  1WEG A;  1MUD A;  1XQP A;  4AI5 A;  4EA5 A;  3CWS A;  1KG4 A;  4HSB A;  4YOQ A;  2YG9 A;  3OH6 A;  4EW0 A;  4B21 A; 
#chains in the Genus database with same CATH topology
 1KG6 A;  5DPK A;  3CWU A;  3IH7 A;  1KG7 A;  4OFA A;  3CW7 A;  3FSP A;  3D4V A;  3OY9 A;  2I5W A;  2NOE A;  2W04 A;  3FHF A;  4BE2 A;  3IHO A;  1N3C A;  3CWT A;  3I0X A;  1YQL A;  4EW0 A;  4EW4 A;  4BDZ A;  4AI4 A;  4ZTF A;  4BE1 A;  1DIZ A;  1EBM A;  1LWY A;  1WEI A;  1PVS A;  4PII A;  1PU6 A;  1KG3 A;  3NNQ A;  4OFH A;  1NKU A;  2OFK A;  2ABK A;  3L2R A;  5FRN A;  3OH6 A;  4EJZ A;  1YQM A;  3FHG A;  3OS0 A;  2NOI A;  3OYD A;  1LMZ A;  4B24 A;  1XQO A;  3G0Q A;  3CVT A;  4DK9 A;  1KQJ A;  1HU0 A;  4UOB A;  1ORP A;  5FRO A;  1ORN A;  3L2V A;  1FN7 A;  4BAC A;  2NOF A;  2H56 A;  3S3N A;  1MUY A;  4EJY A;  2NOB A;  1N3A A;  1KG2 A;  4YPH A;  5CHZ A;  3OYJ A;  4BE0 A;  4E9F A;  1PU7 A;  3OYB A;  3OYL A;  4BDY A;  3OYC A;  3I0W A;  4E9H A;  1PU8 A;  3VW4 A;  4EA4 A;  3OYH A;  4B22 A;  4IKF A;  2JHN A;  1WEF A;  3OYN A;  3CVS A;  1VRL A;  1NGN A;  1KO9 A;  1LWV A;  2NOH A;  1XG7 A;  3OYF A;  1YQK A;  1P59 A;  4EVV A;  5KN9 A;  3CWA A;  2JG6 A;  2JPS A;  3OYA A;  1N39 A;  4E9E A;  3OYK A;  1MUN A;  1YQR A;  4OFE A;  4E7K A;  1M3Q A;  3OYG A;  3OGD A;  5AN4 A;  4E9G A;  4E7I A;  1M3H A;  3S6I A;  2NOL A;  4E7J A;  4AIA A;  3KTU A;  3KNT A;  2V75 A;  1U84 A;  3S3M A;  3L2U A;  4B23 A;  5FRM A;  3F0Z A;  2XHI A;  1KG5 A;  1MPG A;  3L2W A;  1P7M A;  5KN8 A;  1LWW A;  2JHJ A;  1RRS A;  3N0U A;  1RRQ A;  3OYM A;  2YG8 A;  4NZG A;  3R2X C;  3F10 A;  4ZTJ A;  3OH9 A;  1KEA A;  3N5N X;  4UNF A;  3OYE A;  4YPR A;  3L2Q A;  4E7L A;  2OFI A;  2NOZ A;  1WEG A;  1MUD A;  3OYI A;  1XQP A;  4AI5 A;  4EA5 A;  3CWS A;  3LCN A;  4E7H A;  3S3O A;  1KG4 A;  4HSB A;  4YOQ A;  2W03 A;  2YG9 A;  3OS2 A;  3OS1 A;  4B21 A; 
#chains in the Genus database with same CATH homology
 1KG6 A;  5DPK A;  3CWU A;  3IH7 A;  1KG7 A;  4OFA A;  3CW7 A;  3FSP A;  3D4V A;  2I5W A;  2NOE A;  3FHF A;  3IHO A;  1N3C A;  3CWT A;  3I0X A;  1YQL A;  4EW4 A;  4AI4 A;  1DIZ A;  1EBM A;  1LWY A;  1WEI A;  1PVS A;  4PII A;  1PU6 A;  1KG3 A;  4OFH A;  1NKU A;  2OFK A;  2ABK A;  4EJZ A;  1YQM A;  3FHG A;  2NOI A;  1LMZ A;  4B24 A;  1XQO A;  3G0Q A;  3CVT A;  4DK9 A;  1KQJ A;  1HU0 A;  4UOB A;  1ORP A;  1ORN A;  1FN7 A;  2NOF A;  2H56 A;  4EJY A;  1MUY A;  2NOB A;  1N3A A;  1KG2 A;  4YPH A;  5CHZ A;  4E9F A;  1PU7 A;  4E9H A;  3I0W A;  1PU8 A;  4EA4 A;  4B22 A;  2JHN A;  1WEF A;  3CVS A;  1VRL A;  1NGN A;  1KO9 A;  1LWV A;  2NOH A;  1XG7 A;  1YQK A;  1P59 A;  4EVV A;  5KN9 A;  3CWA A;  2JG6 A;  1N39 A;  4E9E A;  1MUN A;  1YQR A;  4OFE A;  1M3Q A;  3OGD A;  5AN4 A;  4E9G A;  1M3H A;  3S6I A;  2NOL A;  4AIA A;  3KTU A;  3KNT A;  4B23 A;  3F0Z A;  2XHI A;  1KG5 A;  1MPG A;  1P7M A;  5KN8 A;  1LWW A;  2JHJ A;  1RRS A;  3N0U A;  1RRQ A;  2YG8 A;  3F10 A;  3OH9 A;  1KEA A;  3N5N X;  4UNF A;  2OFI A;  4YPR A;  2NOZ A;  1WEG A;  1MUD A;  1XQP A;  4AI5 A;  4EA5 A;  3CWS A;  1KG4 A;  4HSB A;  4YOQ A;  2YG9 A;  3OH6 A;  4EW0 A;  4B21 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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