4E9GA

Structure of the glycosylase domain of mbd4 bound to thymine containing dna
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
138
structure length
138
Chain Sequence
WTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEAHKLNKYHDWLWENHE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.
pubmed doi rcsb
molecule tags Hydrolase/dna
source organism Homo sapiens
molecule keywords Methyl-CpG-binding domain protein 4
total genus 43
structure length 138
sequence length 138
ec nomenclature ec 3.2.2.-:
pdb deposition date 2012-03-21
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4e9gA00
1LWVA 3CVSA 1KG7A 4OFAA 1RRSA 4EVVA 3CVTA 1M3HA 1KG6A 4YOQA 3I0WA 3KNTA 4PIIA 2NOZA 4B21A 4HSBA 1KQJA 4YPRA 4AI4A 3G0QA 3FHFA 1LWWA 4YPHA 2YG8A 2NOBA 1KEAA 1KG2A 2I5WA 1WEIA 1P7MA 1M3QA 1FN7A 1PU8A 1N3CA 1XG7A 3F10A 4B22A 4AI5A 1YQMA 1WEFA 4E9FA 4EA4A 1NKUA 2JHNA 2NOLA 5KN8A 1HU0A 3N0UA 3CW7A 3FHGA 3CWAA 4EJYA 1LMZA 1XQOA 4EW4A 4EA5A 1NGNA 1YQKA 1YQRA 1MUYA 2ABKA 1N39A 1KG3A 4B24A 2NOEA 4B23A 4EJZA 1ORNA 1DIZA 5AN4A 1VRLA 5DPKA 3OGDA 1MPGA 2NOIA 3D4VA 1EBMA 3CWSA 3F0ZA 1MUDA 4UOBA 4DK9A 3S6IA 4EW0A 3IH7A 2XHIA 1LWYA 3CWTA 5KN9A 1N3AA 1MUNA 1PU6A 3I0XA 2H56A 1RRQA 1KO9A 1PVSA 2NOFA 4AIAA 5CHZA 1WEGA 4E9EA 3OH6A 1PU7A 3KTUA 4OFHA 4OFEA 3OH9A 2OFKA 1YQLA 3CWUA 3N5NX 1XQPA 1P59A 1ORPA 2YG9A 3FSPA 4E9GA 4E9HA 1KG4A 2NOHA 4UNFA 2OFIA 3IHOA 2JG6A 2JHJA 1KG5A
chains in the Genus database with same CATH superfamily
3OYHA 4BE2A 5FRNA 1LWVA 3CVSA 1KG7A 4OFAA 1RRSA 4EVVA 4BE0A 3CVTA 3S3MA 1M3HA 1KG6A 4YOQA 3I0WA 3KNTA 4PIIA 2NOZA 4B21A 3OYCA 4HSBA 4E7KA 1KQJA 4YPRA 2W04A 4AI4A 3G0QA 3FHFA 1LWWA 4YPHA 2YG8A 2NOBA 1KEAA 3OS1A 1KG2A 2I5WA 1WEIA 1P7MA 1M3QA 3LCNA 1FN7A 3OY9A 1PU8A 1N3CA 1XG7A 3F10A 4B22A 4AI5A 3L2UA 3OYNA 1YQMA 1WEFA 5FRMA 3OYIA 3R2XC 4E9FA 4EA4A 1NKUA 2JHNA 2NOLA 5KN8A 1HU0A 3N0UA 3OYKA 4E7LA 3CW7A 3FHGA 3CWAA 4EJYA 3L2QA 1LMZA 4ZTJA 1XQOA 4NZGA 4EW4A 4EA5A 1NGNA 4ZTFA 1YQKA 1YQRA 1MUYA 2ABKA 3OYLA 1N39A 1KG3A 4B24A 3L2WA 3OYAA 2W03A 4B23A 2NOEA 3OS2A 1ORNA 1DIZA 4EJZA 5AN4A 4E7JA 1VRLA 3OYJA 5DPKA 3OGDA 1MPGA 2NOIA 3D4VA 1EBMA 3CWSA 3OYFA 3F0ZA 1MUDA 4UOBA 4DK9A 3S6IA 4EW0A 3L2RA 3IH7A 2XHIA 3OYMA 4BACA 2JPSA 2V75A 1LWYA 3OYBA 3CWTA 4IKFA 5KN9A 3S3OA 3OYEA 1MUNA 4BDZA 1N3AA 1PU6A 3I0XA 2H56A 1RRQA 1KO9A 1PVSA 2NOFA 4AIAA 5CHZA 1WEGA 4E9EA 3OH6A 1PU7A 1U84A 4OFHA 3OYGA 4OFEA 3NNQA 3KTUA 3OH9A 5FROA 2OFKA 4E7IA 1YQLA 3CWUA 3N5NX 1XQPA 3OS0A 3S3NA 1P59A 4BE1A 1ORPA 3L2VA 2YG9A 3FSPA 4BDYA 4E7HA 3VW4A 3OYDA 4E9GA 4E9HA 1KG4A 2NOHA 4UNFA 2OFIA 3IHOA 2JG6A 2JHJA 1KG5A
chains in the Genus database with same CATH topology
1LWVA 3CVSA 1KG7A 4OFAA 1RRSA 4EVVA 3CVTA 1M3HA 1KG6A 4YOQA 3I0WA 3KNTA 4PIIA 2NOZA 4B21A 4HSBA 1KQJA 4YPRA 4AI4A 3G0QA 3FHFA 1LWWA 4YPHA 2YG8A 2NOBA 1KEAA 1KG2A 2I5WA 1WEIA 1P7MA 1M3QA 1FN7A 1PU8A 1N3CA 1XG7A 3F10A 4B22A 4AI5A 1YQMA 1WEFA 4E9FA 4EA4A 1NKUA 2JHNA 2NOLA 5KN8A 1HU0A 3N0UA 3CW7A 3FHGA 3CWAA 4EJYA 1LMZA 1XQOA 4EW4A 4EA5A 1NGNA 1YQKA 1YQRA 1MUYA 2ABKA 1N39A 1KG3A 4B24A 2NOEA 4B23A 4EJZA 1ORNA 1DIZA 5AN4A 1VRLA 5DPKA 3OGDA 1MPGA 2NOIA 3D4VA 1EBMA 3CWSA 3F0ZA 1MUDA 4UOBA 4DK9A 3S6IA 4EW0A 3IH7A 2XHIA 1LWYA 3CWTA 5KN9A 1N3AA 1MUNA 1PU6A 3I0XA 2H56A 1RRQA 1KO9A 1PVSA 2NOFA 4AIAA 5CHZA 1WEGA 4E9EA 3OH6A 1PU7A 3KTUA 4OFHA 4OFEA 3OH9A 2OFKA 1YQLA 3CWUA 3N5NX 1XQPA 1P59A 1ORPA 2YG9A 3FSPA 4E9GA 4E9HA 1KG4A 2NOHA 4UNFA 2OFIA 3IHOA 2JG6A 2JHJA 1KG5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1LWV A;  3CVS A;  1KG7 A;  4OFA A;  1RRS A;  4EVV A;  3CVT A;  1M3H A;  1KG6 A;  4YOQ A;  3I0W A;  3KNT A;  4PII A;  2NOZ A;  4B21 A;  4HSB A;  1KQJ A;  4YPR A;  4AI4 A;  3G0Q A;  3FHF A;  1LWW A;  4YPH A;  2YG8 A;  2NOB A;  1KEA A;  1KG2 A;  2I5W A;  1WEI A;  1P7M A;  1M3Q A;  1FN7 A;  1PU8 A;  1N3C A;  1XG7 A;  3F10 A;  4B22 A;  4AI5 A;  1YQM A;  1WEF A;  4E9F A;  4EA4 A;  1NKU A;  2JHN A;  2NOL A;  5KN8 A;  1HU0 A;  3N0U A;  3CW7 A;  3FHG A;  3CWA A;  4EJY A;  1LMZ A;  1XQO A;  4EW4 A;  4EA5 A;  1NGN A;  1YQK A;  1YQR A;  1MUY A;  2ABK A;  1N39 A;  1KG3 A;  4B24 A;  2NOE A;  4B23 A;  4EJZ A;  1ORN A;  1DIZ A;  5AN4 A;  1VRL A;  5DPK A;  3OGD A;  1MPG A;  2NOI A;  3D4V A;  1EBM A;  3CWS A;  3F0Z A;  1MUD A;  4UOB A;  4DK9 A;  3S6I A;  4EW0 A;  3IH7 A;  2XHI A;  1LWY A;  3CWT A;  5KN9 A;  1N3A A;  1MUN A;  1PU6 A;  3I0X A;  2H56 A;  1RRQ A;  1KO9 A;  1PVS A;  2NOF A;  4AIA A;  5CHZ A;  1WEG A;  4E9E A;  3OH6 A;  1PU7 A;  3KTU A;  4OFH A;  4OFE A;  3OH9 A;  2OFK A;  1YQL A;  3CWU A;  3N5N X;  1XQP A;  1P59 A;  1ORP A;  2YG9 A;  3FSP A;  4E9G A;  4E9H A;  1KG4 A;  2NOH A;  4UNF A;  2OFI A;  3IHO A;  2JG6 A;  2JHJ A;  1KG5 A; 
#chains in the Genus database with same CATH topology
 3OYH A;  4BE2 A;  5FRN A;  1LWV A;  3CVS A;  1KG7 A;  4OFA A;  1RRS A;  4EVV A;  4BE0 A;  3CVT A;  3S3M A;  1M3H A;  1KG6 A;  4YOQ A;  3I0W A;  3KNT A;  4PII A;  2NOZ A;  4B21 A;  3OYC A;  4HSB A;  4E7K A;  1KQJ A;  4YPR A;  2W04 A;  4AI4 A;  3G0Q A;  3FHF A;  1LWW A;  4YPH A;  2YG8 A;  2NOB A;  1KEA A;  3OS1 A;  1KG2 A;  2I5W A;  1WEI A;  1P7M A;  1M3Q A;  3LCN A;  1FN7 A;  3OY9 A;  1PU8 A;  1N3C A;  1XG7 A;  3F10 A;  4B22 A;  4AI5 A;  3L2U A;  3OYN A;  1YQM A;  1WEF A;  5FRM A;  3OYI A;  3R2X C;  4E9F A;  4EA4 A;  1NKU A;  2JHN A;  2NOL A;  5KN8 A;  1HU0 A;  3N0U A;  3OYK A;  4E7L A;  3CW7 A;  3FHG A;  3CWA A;  4EJY A;  3L2Q A;  1LMZ A;  4ZTJ A;  1XQO A;  4NZG A;  4EW4 A;  4EA5 A;  1NGN A;  4ZTF A;  1YQK A;  1YQR A;  1MUY A;  2ABK A;  3OYL A;  1N39 A;  1KG3 A;  4B24 A;  3L2W A;  3OYA A;  2W03 A;  4B23 A;  2NOE A;  3OS2 A;  1ORN A;  1DIZ A;  4EJZ A;  5AN4 A;  4E7J A;  1VRL A;  3OYJ A;  5DPK A;  3OGD A;  1MPG A;  2NOI A;  3D4V A;  1EBM A;  3CWS A;  3OYF A;  3F0Z A;  1MUD A;  4UOB A;  4DK9 A;  3S6I A;  4EW0 A;  3L2R A;  3IH7 A;  2XHI A;  3OYM A;  4BAC A;  2JPS A;  2V75 A;  1LWY A;  3OYB A;  3CWT A;  4IKF A;  5KN9 A;  3S3O A;  3OYE A;  1MUN A;  4BDZ A;  1N3A A;  1PU6 A;  3I0X A;  2H56 A;  1RRQ A;  1KO9 A;  1PVS A;  2NOF A;  4AIA A;  5CHZ A;  1WEG A;  4E9E A;  3OH6 A;  1PU7 A;  1U84 A;  4OFH A;  3OYG A;  4OFE A;  3NNQ A;  3KTU A;  3OH9 A;  5FRO A;  2OFK A;  4E7I A;  1YQL A;  3CWU A;  3N5N X;  1XQP A;  3OS0 A;  3S3N A;  1P59 A;  4BE1 A;  1ORP A;  3L2V A;  2YG9 A;  3FSP A;  4BDY A;  4E7H A;  3VW4 A;  3OYD A;  4E9G A;  4E9H A;  1KG4 A;  2NOH A;  4UNF A;  2OFI A;  3IHO A;  2JG6 A;  2JHJ A;  1KG5 A; 
#chains in the Genus database with same CATH homology
 1LWV A;  3CVS A;  1KG7 A;  4OFA A;  1RRS A;  4EVV A;  3CVT A;  1M3H A;  1KG6 A;  4YOQ A;  3I0W A;  3KNT A;  4PII A;  2NOZ A;  4B21 A;  4HSB A;  1KQJ A;  4YPR A;  4AI4 A;  3G0Q A;  3FHF A;  1LWW A;  4YPH A;  2YG8 A;  2NOB A;  1KEA A;  1KG2 A;  2I5W A;  1WEI A;  1P7M A;  1M3Q A;  1FN7 A;  1PU8 A;  1N3C A;  1XG7 A;  3F10 A;  4B22 A;  4AI5 A;  1YQM A;  1WEF A;  4E9F A;  4EA4 A;  1NKU A;  2JHN A;  2NOL A;  5KN8 A;  1HU0 A;  3N0U A;  3CW7 A;  3FHG A;  3CWA A;  4EJY A;  1LMZ A;  1XQO A;  4EW4 A;  4EA5 A;  1NGN A;  1YQK A;  1YQR A;  1MUY A;  2ABK A;  1N39 A;  1KG3 A;  4B24 A;  2NOE A;  4B23 A;  4EJZ A;  1ORN A;  1DIZ A;  5AN4 A;  1VRL A;  5DPK A;  3OGD A;  1MPG A;  2NOI A;  3D4V A;  1EBM A;  3CWS A;  3F0Z A;  1MUD A;  4UOB A;  4DK9 A;  3S6I A;  4EW0 A;  3IH7 A;  2XHI A;  1LWY A;  3CWT A;  5KN9 A;  1N3A A;  1MUN A;  1PU6 A;  3I0X A;  2H56 A;  1RRQ A;  1KO9 A;  1PVS A;  2NOF A;  4AIA A;  5CHZ A;  1WEG A;  4E9E A;  3OH6 A;  1PU7 A;  3KTU A;  4OFH A;  4OFE A;  3OH9 A;  2OFK A;  1YQL A;  3CWU A;  3N5N X;  1XQP A;  1P59 A;  1ORP A;  2YG9 A;  3FSP A;  4E9G A;  4E9H A;  1KG4 A;  2NOH A;  4UNF A;  2OFI A;  3IHO A;  2JG6 A;  2JHJ A;  1KG5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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