4E9GA

Structure of the glycosylase domain of mbd4 bound to thymine containing dna
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
138
structure length
138
Chain Sequence
WTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEAHKLNKYHDWLWENHE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/dna
source organism Homo sapiens
publication title Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.
pubmed doi rcsb
molecule keywords Methyl-CpG-binding domain protein 4
total genus 43
structure length 138
sequence length 138
ec nomenclature ec 3.2.2.-:
pdb deposition date 2012-03-21
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4e9gA00
3KNTA 3FSPA 4YPRA 3FHGA 1N3AA 4E9GA 1MUYA 2YG8A 4AIAA 2JHNA 1M3HA 3CWUA 2NOFA 4EJYA 4UNFA 2H56A 1RRSA 2OFIA 4B21A 4EA4A 2NOIA 1WEGA 3N0UA 2I5WA 5AN4A 3CWSA 1MUNA 4OFAA 5DPKA 1MPGA 1KG6A 3F10A 1N3CA 2NOHA 2JG6A 2YG9A 4EJZA 1PU6A 4OFHA 1NGNA 4OFEA 1KG5A 1XQPA 4EA5A 4EW0A 3S6IA 1NKUA 1MUDA 4E9EA 3CVSA 3OGDA 1N39A 3OH9A 3G0QA 2JHJA 5KN8A 4B22A 2ABKA 3F0ZA 1WEIA 1WEFA 5KN9A 4PIIA 4DK9A 1YQMA 1YQLA 1PU7A 4E9FA 1FN7A 1KEAA 4B23A 1HU0A 3I0XA 1YQRA 1YQKA 2NOBA 3IH7A 1KG2A 3KTUA 1XQOA 4UOBA 1P59A 1P7MA 4B24A 3D4VA 1EBMA 4E9HA 1LWYA 1RRQA 1KG4A 1LMZA 1KG3A 2NOEA 3CWAA 4AI5A 3CVTA 1VRLA 3N5NX 1DIZA 4YOQA 3CW7A 3IHOA 2NOLA 5CHZA 3OH6A 4EW4A 1KQJA 1LWWA 4EVVA 4AI4A 1KO9A 1PU8A 2OFKA 4HSBA 2XHIA 3I0WA 3FHFA 2NOZA 1M3QA 4YPHA 1ORNA 3CWTA 1XG7A 1PVSA 1ORPA 1KG7A 1LWVA
chains in the Genus database with same CATH superfamily
3KNTA 3OYDA 3OYKA 3FSPA 4YPRA 3FHGA 1N3AA 4BE1A 4E9GA 3S3NA 1MUYA 2YG8A 4AIAA 2JHNA 1M3HA 3OYGA 3CWUA 2NOFA 4EJYA 4UNFA 2H56A 3OYIA 1RRSA 2OFIA 3OYHA 4B21A 4EA4A 2NOIA 1WEGA 3N0UA 2I5WA 5AN4A 3L2VA 1MUNA 4OFAA 3S3MA 5DPKA 3CWSA 1MPGA 3NNQA 1KG6A 3F10A 1N3CA 5FRMA 2NOHA 2JG6A 4ZTFA 2YG9A 3OYBA 3OS1A 5FRNA 3L2RA 4EJZA 1PU6A 4OFHA 3L2WA 1NGNA 4OFEA 1U84A 1KG5A 1XQPA 4EA5A 4EW0A 4E7LA 3S6IA 1NKUA 4E7HA 3OYJA 1MUDA 2JPSA 4BE2A 4E9EA 3CVSA 3OGDA 4BDYA 1N39A 4BACA 3OH9A 3G0QA 2JHJA 5KN8A 4B22A 2ABKA 3F0ZA 1WEIA 1WEFA 5KN9A 4PIIA 3OYCA 4DK9A 4E7KA 1YQMA 3VW4A 1YQLA 4E7JA 1PU7A 4E9FA 1FN7A 1KEAA 4B23A 3LCNA 1HU0A 3I0XA 1YQRA 1YQKA 2NOBA 3IH7A 1KG2A 4NZGA 3KTUA 5FROA 1XQOA 4UOBA 1P59A 1P7MA 3OY9A 4B24A 3D4VA 1EBMA 3L2UA 4E9HA 3OS2A 1LWYA 1RRQA 4BDZA 1KG4A 1LMZA 3OYMA 1KG3A 2NOEA 3OS0A 3CWAA 4AI5A 3CVTA 1VRLA 3N5NX 1DIZA 4YOQA 3OYNA 4BE0A 3CW7A 3IHOA 3L2QA 2NOLA 5CHZA 3OYLA 3OH6A 3OYEA 4EW4A 1KQJA 1LWWA 4EVVA 4AI4A 4ZTJA 3OYAA 1KO9A 1PU8A 2OFKA 2W03A 2XHIA 4HSBA 3S3OA 2V75A 3I0WA 3FHFA 3OYFA 4E7IA 2NOZA 1M3QA 4YPHA 1ORNA 3CWTA 1XG7A 4IKFA 2W04A 1PVSA 1ORPA 1KG7A 3R2XC 1LWVA
chains in the Genus database with same CATH topology
3KNTA 3FSPA 4YPRA 3FHGA 1N3AA 4E9GA 1MUYA 2YG8A 4AIAA 2JHNA 1M3HA 3CWUA 2NOFA 4EJYA 4UNFA 2H56A 1RRSA 2OFIA 4B21A 4EA4A 2NOIA 1WEGA 3N0UA 2I5WA 5AN4A 3CWSA 1MUNA 4OFAA 5DPKA 1MPGA 1KG6A 3F10A 1N3CA 2NOHA 2JG6A 2YG9A 4EJZA 1PU6A 4OFHA 1NGNA 4OFEA 1KG5A 1XQPA 4EA5A 4EW0A 3S6IA 1NKUA 1MUDA 4E9EA 3CVSA 3OGDA 1N39A 3OH9A 3G0QA 2JHJA 5KN8A 4B22A 2ABKA 3F0ZA 1WEIA 1WEFA 5KN9A 4PIIA 4DK9A 1YQMA 1YQLA 1PU7A 4E9FA 1FN7A 1KEAA 4B23A 1HU0A 3I0XA 1YQRA 1YQKA 2NOBA 3IH7A 1KG2A 3KTUA 1XQOA 4UOBA 1P59A 1P7MA 4B24A 3D4VA 1EBMA 4E9HA 1LWYA 1RRQA 1KG4A 1LMZA 1KG3A 2NOEA 3CWAA 4AI5A 3CVTA 1VRLA 3N5NX 1DIZA 4YOQA 3CW7A 3IHOA 2NOLA 5CHZA 3OH6A 4EW4A 1KQJA 1LWWA 4EVVA 4AI4A 1KO9A 1PU8A 2OFKA 4HSBA 2XHIA 3I0WA 3FHFA 2NOZA 1M3QA 4YPHA 1ORNA 3CWTA 1XG7A 1PVSA 1ORPA 1KG7A 1LWVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3KNT A;  3FSP A;  4YPR A;  3FHG A;  1N3A A;  4E9G A;  1MUY A;  2YG8 A;  4AIA A;  2JHN A;  1M3H A;  3CWU A;  2NOF A;  4EJY A;  4UNF A;  2H56 A;  1RRS A;  2OFI A;  4B21 A;  4EA4 A;  2NOI A;  1WEG A;  3N0U A;  2I5W A;  5AN4 A;  3CWS A;  1MUN A;  4OFA A;  5DPK A;  1MPG A;  1KG6 A;  3F10 A;  1N3C A;  2NOH A;  2JG6 A;  2YG9 A;  4EJZ A;  1PU6 A;  4OFH A;  1NGN A;  4OFE A;  1KG5 A;  1XQP A;  4EA5 A;  4EW0 A;  3S6I A;  1NKU A;  1MUD A;  4E9E A;  3CVS A;  3OGD A;  1N39 A;  3OH9 A;  3G0Q A;  2JHJ A;  5KN8 A;  4B22 A;  2ABK A;  3F0Z A;  1WEI A;  1WEF A;  5KN9 A;  4PII A;  4DK9 A;  1YQM A;  1YQL A;  1PU7 A;  4E9F A;  1FN7 A;  1KEA A;  4B23 A;  1HU0 A;  3I0X A;  1YQR A;  1YQK A;  2NOB A;  3IH7 A;  1KG2 A;  3KTU A;  1XQO A;  4UOB A;  1P59 A;  1P7M A;  4B24 A;  3D4V A;  1EBM A;  4E9H A;  1LWY A;  1RRQ A;  1KG4 A;  1LMZ A;  1KG3 A;  2NOE A;  3CWA A;  4AI5 A;  3CVT A;  1VRL A;  3N5N X;  1DIZ A;  4YOQ A;  3CW7 A;  3IHO A;  2NOL A;  5CHZ A;  3OH6 A;  4EW4 A;  1KQJ A;  1LWW A;  4EVV A;  4AI4 A;  1KO9 A;  1PU8 A;  2OFK A;  4HSB A;  2XHI A;  3I0W A;  3FHF A;  2NOZ A;  1M3Q A;  4YPH A;  1ORN A;  3CWT A;  1XG7 A;  1PVS A;  1ORP A;  1KG7 A;  1LWV A; 
#chains in the Genus database with same CATH topology
 3KNT A;  3OYD A;  3OYK A;  3FSP A;  4YPR A;  3FHG A;  1N3A A;  4BE1 A;  4E9G A;  3S3N A;  1MUY A;  2YG8 A;  4AIA A;  2JHN A;  1M3H A;  3OYG A;  3CWU A;  2NOF A;  4EJY A;  4UNF A;  2H56 A;  3OYI A;  1RRS A;  2OFI A;  3OYH A;  4B21 A;  4EA4 A;  2NOI A;  1WEG A;  3N0U A;  2I5W A;  5AN4 A;  3L2V A;  1MUN A;  4OFA A;  3S3M A;  5DPK A;  3CWS A;  1MPG A;  3NNQ A;  1KG6 A;  3F10 A;  1N3C A;  5FRM A;  2NOH A;  2JG6 A;  4ZTF A;  2YG9 A;  3OYB A;  3OS1 A;  5FRN A;  3L2R A;  4EJZ A;  1PU6 A;  4OFH A;  3L2W A;  1NGN A;  4OFE A;  1U84 A;  1KG5 A;  1XQP A;  4EA5 A;  4EW0 A;  4E7L A;  3S6I A;  1NKU A;  4E7H A;  3OYJ A;  1MUD A;  2JPS A;  4BE2 A;  4E9E A;  3CVS A;  3OGD A;  4BDY A;  1N39 A;  4BAC A;  3OH9 A;  3G0Q A;  2JHJ A;  5KN8 A;  4B22 A;  2ABK A;  3F0Z A;  1WEI A;  1WEF A;  5KN9 A;  4PII A;  3OYC A;  4DK9 A;  4E7K A;  1YQM A;  3VW4 A;  1YQL A;  4E7J A;  1PU7 A;  4E9F A;  1FN7 A;  1KEA A;  4B23 A;  3LCN A;  1HU0 A;  3I0X A;  1YQR A;  1YQK A;  2NOB A;  3IH7 A;  1KG2 A;  4NZG A;  3KTU A;  5FRO A;  1XQO A;  4UOB A;  1P59 A;  1P7M A;  3OY9 A;  4B24 A;  3D4V A;  1EBM A;  3L2U A;  4E9H A;  3OS2 A;  1LWY A;  1RRQ A;  4BDZ A;  1KG4 A;  1LMZ A;  3OYM A;  1KG3 A;  2NOE A;  3OS0 A;  3CWA A;  4AI5 A;  3CVT A;  1VRL A;  3N5N X;  1DIZ A;  4YOQ A;  3OYN A;  4BE0 A;  3CW7 A;  3IHO A;  3L2Q A;  2NOL A;  5CHZ A;  3OYL A;  3OH6 A;  3OYE A;  4EW4 A;  1KQJ A;  1LWW A;  4EVV A;  4AI4 A;  4ZTJ A;  3OYA A;  1KO9 A;  1PU8 A;  2OFK A;  2W03 A;  2XHI A;  4HSB A;  3S3O A;  2V75 A;  3I0W A;  3FHF A;  3OYF A;  4E7I A;  2NOZ A;  1M3Q A;  4YPH A;  1ORN A;  3CWT A;  1XG7 A;  4IKF A;  2W04 A;  1PVS A;  1ORP A;  1KG7 A;  3R2X C;  1LWV A; 
#chains in the Genus database with same CATH homology
 3KNT A;  3FSP A;  4YPR A;  3FHG A;  1N3A A;  4E9G A;  1MUY A;  2YG8 A;  4AIA A;  2JHN A;  1M3H A;  3CWU A;  2NOF A;  4EJY A;  4UNF A;  2H56 A;  1RRS A;  2OFI A;  4B21 A;  4EA4 A;  2NOI A;  1WEG A;  3N0U A;  2I5W A;  5AN4 A;  3CWS A;  1MUN A;  4OFA A;  5DPK A;  1MPG A;  1KG6 A;  3F10 A;  1N3C A;  2NOH A;  2JG6 A;  2YG9 A;  4EJZ A;  1PU6 A;  4OFH A;  1NGN A;  4OFE A;  1KG5 A;  1XQP A;  4EA5 A;  4EW0 A;  3S6I A;  1NKU A;  1MUD A;  4E9E A;  3CVS A;  3OGD A;  1N39 A;  3OH9 A;  3G0Q A;  2JHJ A;  5KN8 A;  4B22 A;  2ABK A;  3F0Z A;  1WEI A;  1WEF A;  5KN9 A;  4PII A;  4DK9 A;  1YQM A;  1YQL A;  1PU7 A;  4E9F A;  1FN7 A;  1KEA A;  4B23 A;  1HU0 A;  3I0X A;  1YQR A;  1YQK A;  2NOB A;  3IH7 A;  1KG2 A;  3KTU A;  1XQO A;  4UOB A;  1P59 A;  1P7M A;  4B24 A;  3D4V A;  1EBM A;  4E9H A;  1LWY A;  1RRQ A;  1KG4 A;  1LMZ A;  1KG3 A;  2NOE A;  3CWA A;  4AI5 A;  3CVT A;  1VRL A;  3N5N X;  1DIZ A;  4YOQ A;  3CW7 A;  3IHO A;  2NOL A;  5CHZ A;  3OH6 A;  4EW4 A;  1KQJ A;  1LWW A;  4EVV A;  4AI4 A;  1KO9 A;  1PU8 A;  2OFK A;  4HSB A;  2XHI A;  3I0W A;  3FHF A;  2NOZ A;  1M3Q A;  4YPH A;  1ORN A;  3CWT A;  1XG7 A;  1PVS A;  1ORP A;  1KG7 A;  1LWV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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