4E9HA

Structure of glycosylase domain of mbd4 bound to 5hmu containing dna
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
137
structure length
137
Chain Sequence
WTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEAHKLNKYHDWLWENH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/dna
source organism Homo sapiens
publication title Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.
pubmed doi rcsb
molecule keywords Methyl-CpG-binding domain protein 4
total genus 49
structure length 137
sequence length 137
ec nomenclature ec 3.2.2.-:
pdb deposition date 2012-03-21
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4e9hA00
1M3QA 3CWSA 2JHJA 4EA5A 1EBMA 4B23A 3OH6A 1FN7A 4E9FA 2I5WA 2NOFA 1RRQA 3KNTA 3CVTA 3CWTA 1KG7A 2NOLA 3N5NX 3FHGA 4AI5A 1XQOA 3OGDA 3CVSA 1WEFA 2H56A 2NOZA 1YQMA 2NOHA 1N3AA 2OFKA 1MUNA 1NGNA 2NOEA 3FHFA 2NOBA 1KQJA 3I0XA 4E9HA 1N39A 1KO9A 4OFHA 1KEAA 2YG9A 3G0QA 5DPKA 1YQLA 3N0UA 4B22A 1KG4A 4UOBA 1KG6A 4EJYA 1WEGA 3F10A 1NKUA 1PU8A 2JG6A 4E9EA 4EA4A 4PIIA 4AIAA 1PU6A 3OH9A 1MPGA 1LWWA 1YQKA 1LWYA 2NOIA 1DIZA 1WEIA 2XHIA 3FSPA 1KG3A 3F0ZA 2JHNA 2YG8A 3I0WA 4E9GA 4OFAA 2OFIA 1YQRA 1XQPA 4B24A 3CWAA 4B21A 1PU7A 1N3CA 3IH7A 4EW0A 4EJZA 1MUYA 5KN8A 4UNFA 3CW7A 5AN4A 3IHOA 4EVVA 5KN9A 1RRSA 1XG7A 4DK9A 1LWVA 1VRLA 4OFEA 3S6IA 3KTUA 4EW4A 1KG2A 1MUDA 4YPHA 4YPRA 1ORNA 1ORPA 1PVSA 4AI4A 5CHZA 1P7MA 4HSBA 1LMZA 2ABKA 3D4VA 4YOQA 1P59A 1HU0A 1M3HA 1KG5A 3CWUA
chains in the Genus database with same CATH superfamily
1M3QA 3CWSA 2JHJA 4EA5A 5FROA 3OYLA 3OYAA 1U84A 1EBMA 3OYFA 4B23A 3OH6A 1FN7A 4E9FA 2I5WA 2NOFA 1RRQA 3KNTA 3CVTA 3R2XC 3CWTA 4IKFA 1KG7A 2NOLA 3N5NX 3FHGA 3OYBA 4AI5A 4E7JA 1XQOA 3OGDA 3L2VA 3CVSA 1WEFA 2H56A 2NOZA 1YQMA 2NOHA 1N3AA 2OFKA 1MUNA 1NGNA 2NOEA 3FHFA 2NOBA 1KQJA 3I0XA 4E9HA 1N39A 4BDYA 1KO9A 3S3OA 4OFHA 1KEAA 3LCNA 2YG9A 3OYKA 3G0QA 4BACA 5DPKA 1YQLA 3N0UA 3OYIA 4B22A 5FRMA 1KG4A 4UOBA 1KG6A 4EJYA 1WEGA 4BDZA 3F10A 2W03A 4E7LA 1NKUA 1PU8A 2JPSA 2JG6A 4E9EA 4EA4A 3OYNA 4ZTFA 1HU0A 4PIIA 3L2WA 4AIAA 1PU6A 3OH9A 1MPGA 1LWWA 5FRNA 4E7KA 1YQKA 1LWYA 2V75A 3L2RA 2NOIA 3OYGA 1DIZA 3L2UA 1WEIA 2XHIA 3FSPA 1KG3A 3F0ZA 2JHNA 2YG8A 3OS2A 3I0WA 4E9GA 4OFAA 3OS1A 2OFIA 1YQRA 1XQPA 4B24A 3S3NA 4NZGA 3CWAA 4B21A 1PU7A 1N3CA 3IH7A 4EW0A 3L2QA 4EJZA 1MUYA 5KN8A 3S3MA 4UNFA 4E7HA 2W04A 3CW7A 3NNQA 5AN4A 3IHOA 3OYEA 4EVVA 5KN9A 3OY9A 1RRSA 1XG7A 3OS0A 3OYMA 4BE1A 3OYHA 4DK9A 1LWVA 1VRLA 4OFEA 4BE2A 4BE0A 3S6IA 3KTUA 3OYDA 4EW4A 4ZTJA 1KG2A 1MUDA 4YPHA 4YPRA 1ORNA 1ORPA 3VW4A 1PVSA 4AI4A 3OYCA 5CHZA 1P7MA 4HSBA 3OYJA 1LMZA 2ABKA 3D4VA 4YOQA 1P59A 4E7IA 1M3HA 1KG5A 3CWUA
chains in the Genus database with same CATH topology
1M3QA 3CWSA 2JHJA 4EA5A 1EBMA 4B23A 3OH6A 1FN7A 4E9FA 2I5WA 2NOFA 1RRQA 3KNTA 3CVTA 3CWTA 1KG7A 2NOLA 3N5NX 3FHGA 4AI5A 1XQOA 3OGDA 3CVSA 1WEFA 2H56A 2NOZA 1YQMA 2NOHA 1N3AA 2OFKA 1MUNA 1NGNA 2NOEA 3FHFA 2NOBA 1KQJA 3I0XA 4E9HA 1N39A 1KO9A 4OFHA 1KEAA 2YG9A 3G0QA 5DPKA 1YQLA 3N0UA 4B22A 1KG4A 4UOBA 1KG6A 4EJYA 1WEGA 3F10A 1NKUA 1PU8A 2JG6A 4E9EA 4EA4A 4PIIA 4AIAA 1PU6A 3OH9A 1MPGA 1LWWA 1YQKA 1LWYA 2NOIA 1DIZA 1WEIA 2XHIA 3FSPA 1KG3A 3F0ZA 2JHNA 2YG8A 3I0WA 4E9GA 4OFAA 2OFIA 1YQRA 1XQPA 4B24A 3CWAA 4B21A 1PU7A 1N3CA 3IH7A 4EW0A 4EJZA 1MUYA 5KN8A 4UNFA 3CW7A 5AN4A 3IHOA 4EVVA 5KN9A 1RRSA 1XG7A 4DK9A 1LWVA 1VRLA 4OFEA 3S6IA 3KTUA 4EW4A 1KG2A 1MUDA 4YPHA 4YPRA 1ORNA 1ORPA 1PVSA 4AI4A 5CHZA 1P7MA 4HSBA 1LMZA 2ABKA 3D4VA 4YOQA 1P59A 1HU0A 1M3HA 1KG5A 3CWUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1M3Q A;  3CWS A;  2JHJ A;  4EA5 A;  1EBM A;  4B23 A;  3OH6 A;  1FN7 A;  4E9F A;  2I5W A;  2NOF A;  1RRQ A;  3KNT A;  3CVT A;  3CWT A;  1KG7 A;  2NOL A;  3N5N X;  3FHG A;  4AI5 A;  1XQO A;  3OGD A;  3CVS A;  1WEF A;  2H56 A;  2NOZ A;  1YQM A;  2NOH A;  1N3A A;  2OFK A;  1MUN A;  1NGN A;  2NOE A;  3FHF A;  2NOB A;  1KQJ A;  3I0X A;  4E9H A;  1N39 A;  1KO9 A;  4OFH A;  1KEA A;  2YG9 A;  3G0Q A;  5DPK A;  1YQL A;  3N0U A;  4B22 A;  1KG4 A;  4UOB A;  1KG6 A;  4EJY A;  1WEG A;  3F10 A;  1NKU A;  1PU8 A;  2JG6 A;  4E9E A;  4EA4 A;  4PII A;  4AIA A;  1PU6 A;  3OH9 A;  1MPG A;  1LWW A;  1YQK A;  1LWY A;  2NOI A;  1DIZ A;  1WEI A;  2XHI A;  3FSP A;  1KG3 A;  3F0Z A;  2JHN A;  2YG8 A;  3I0W A;  4E9G A;  4OFA A;  2OFI A;  1YQR A;  1XQP A;  4B24 A;  3CWA A;  4B21 A;  1PU7 A;  1N3C A;  3IH7 A;  4EW0 A;  4EJZ A;  1MUY A;  5KN8 A;  4UNF A;  3CW7 A;  5AN4 A;  3IHO A;  4EVV A;  5KN9 A;  1RRS A;  1XG7 A;  4DK9 A;  1LWV A;  1VRL A;  4OFE A;  3S6I A;  3KTU A;  4EW4 A;  1KG2 A;  1MUD A;  4YPH A;  4YPR A;  1ORN A;  1ORP A;  1PVS A;  4AI4 A;  5CHZ A;  1P7M A;  4HSB A;  1LMZ A;  2ABK A;  3D4V A;  4YOQ A;  1P59 A;  1HU0 A;  1M3H A;  1KG5 A;  3CWU A; 
#chains in the Genus database with same CATH topology
 1M3Q A;  3CWS A;  2JHJ A;  4EA5 A;  5FRO A;  3OYL A;  3OYA A;  1U84 A;  1EBM A;  3OYF A;  4B23 A;  3OH6 A;  1FN7 A;  4E9F A;  2I5W A;  2NOF A;  1RRQ A;  3KNT A;  3CVT A;  3R2X C;  3CWT A;  4IKF A;  1KG7 A;  2NOL A;  3N5N X;  3FHG A;  3OYB A;  4AI5 A;  4E7J A;  1XQO A;  3OGD A;  3L2V A;  3CVS A;  1WEF A;  2H56 A;  2NOZ A;  1YQM A;  2NOH A;  1N3A A;  2OFK A;  1MUN A;  1NGN A;  2NOE A;  3FHF A;  2NOB A;  1KQJ A;  3I0X A;  4E9H A;  1N39 A;  4BDY A;  1KO9 A;  3S3O A;  4OFH A;  1KEA A;  3LCN A;  2YG9 A;  3OYK A;  3G0Q A;  4BAC A;  5DPK A;  1YQL A;  3N0U A;  3OYI A;  4B22 A;  5FRM A;  1KG4 A;  4UOB A;  1KG6 A;  4EJY A;  1WEG A;  4BDZ A;  3F10 A;  2W03 A;  4E7L A;  1NKU A;  1PU8 A;  2JPS A;  2JG6 A;  4E9E A;  4EA4 A;  3OYN A;  4ZTF A;  1HU0 A;  4PII A;  3L2W A;  4AIA A;  1PU6 A;  3OH9 A;  1MPG A;  1LWW A;  5FRN A;  4E7K A;  1YQK A;  1LWY A;  2V75 A;  3L2R A;  2NOI A;  3OYG A;  1DIZ A;  3L2U A;  1WEI A;  2XHI A;  3FSP A;  1KG3 A;  3F0Z A;  2JHN A;  2YG8 A;  3OS2 A;  3I0W A;  4E9G A;  4OFA A;  3OS1 A;  2OFI A;  1YQR A;  1XQP A;  4B24 A;  3S3N A;  4NZG A;  3CWA A;  4B21 A;  1PU7 A;  1N3C A;  3IH7 A;  4EW0 A;  3L2Q A;  4EJZ A;  1MUY A;  5KN8 A;  3S3M A;  4UNF A;  4E7H A;  2W04 A;  3CW7 A;  3NNQ A;  5AN4 A;  3IHO A;  3OYE A;  4EVV A;  5KN9 A;  3OY9 A;  1RRS A;  1XG7 A;  3OS0 A;  3OYM A;  4BE1 A;  3OYH A;  4DK9 A;  1LWV A;  1VRL A;  4OFE A;  4BE2 A;  4BE0 A;  3S6I A;  3KTU A;  3OYD A;  4EW4 A;  4ZTJ A;  1KG2 A;  1MUD A;  4YPH A;  4YPR A;  1ORN A;  1ORP A;  3VW4 A;  1PVS A;  4AI4 A;  3OYC A;  5CHZ A;  1P7M A;  4HSB A;  3OYJ A;  1LMZ A;  2ABK A;  3D4V A;  4YOQ A;  1P59 A;  4E7I A;  1M3H A;  1KG5 A;  3CWU A; 
#chains in the Genus database with same CATH homology
 1M3Q A;  3CWS A;  2JHJ A;  4EA5 A;  1EBM A;  4B23 A;  3OH6 A;  1FN7 A;  4E9F A;  2I5W A;  2NOF A;  1RRQ A;  3KNT A;  3CVT A;  3CWT A;  1KG7 A;  2NOL A;  3N5N X;  3FHG A;  4AI5 A;  1XQO A;  3OGD A;  3CVS A;  1WEF A;  2H56 A;  2NOZ A;  1YQM A;  2NOH A;  1N3A A;  2OFK A;  1MUN A;  1NGN A;  2NOE A;  3FHF A;  2NOB A;  1KQJ A;  3I0X A;  4E9H A;  1N39 A;  1KO9 A;  4OFH A;  1KEA A;  2YG9 A;  3G0Q A;  5DPK A;  1YQL A;  3N0U A;  4B22 A;  1KG4 A;  4UOB A;  1KG6 A;  4EJY A;  1WEG A;  3F10 A;  1NKU A;  1PU8 A;  2JG6 A;  4E9E A;  4EA4 A;  4PII A;  4AIA A;  1PU6 A;  3OH9 A;  1MPG A;  1LWW A;  1YQK A;  1LWY A;  2NOI A;  1DIZ A;  1WEI A;  2XHI A;  3FSP A;  1KG3 A;  3F0Z A;  2JHN A;  2YG8 A;  3I0W A;  4E9G A;  4OFA A;  2OFI A;  1YQR A;  1XQP A;  4B24 A;  3CWA A;  4B21 A;  1PU7 A;  1N3C A;  3IH7 A;  4EW0 A;  4EJZ A;  1MUY A;  5KN8 A;  4UNF A;  3CW7 A;  5AN4 A;  3IHO A;  4EVV A;  5KN9 A;  1RRS A;  1XG7 A;  4DK9 A;  1LWV A;  1VRL A;  4OFE A;  3S6I A;  3KTU A;  4EW4 A;  1KG2 A;  1MUD A;  4YPH A;  4YPR A;  1ORN A;  1ORP A;  1PVS A;  4AI4 A;  5CHZ A;  1P7M A;  4HSB A;  1LMZ A;  2ABK A;  3D4V A;  4YOQ A;  1P59 A;  1HU0 A;  1M3H A;  1KG5 A;  3CWU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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