4E9HA

Structure of glycosylase domain of mbd4 bound to 5hmu containing dna
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
137
structure length
137
Chain Sequence
WTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEAHKLNKYHDWLWENH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.
pubmed doi rcsb
molecule tags Hydrolase/dna
source organism Homo sapiens
molecule keywords Methyl-CpG-binding domain protein 4
total genus 49
structure length 137
sequence length 137
ec nomenclature ec 3.2.2.-:
pdb deposition date 2012-03-21
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4e9hA00
3OH9A 1MPGA 2OFKA 5CHZA 1EBMA 3KNTA 4E9GA 2NOEA 1XQPA 3CWAA 1KEAA 1LWWA 2JHJA 1PVSA 4YPRA 3CWSA 1YQMA 3F10A 2H56A 4OFHA 4DK9A 1DIZA 2JG6A 4UNFA 4B23A 1YQLA 1XQOA 4EVVA 3I0XA 1KG4A 3D4VA 2NOBA 2OFIA 1VRLA 1WEFA 1YQKA 2YG9A 3IH7A 2I5WA 3FSPA 1YQRA 4EA5A 1KO9A 1FN7A 1XG7A 4EJZA 1KQJA 1PU6A 1WEGA 2ABKA 3CVSA 1KG2A 3CVTA 4E9FA 1KG7A 5KN9A 5DPKA 5KN8A 4AI4A 4B24A 1ORNA 1LWVA 1N3AA 1RRQA 4B22A 1P7MA 5AN4A 3G0QA 1LWYA 1PU8A 1KG5A 1KG6A 3CW7A 3OH6A 4EJYA 4OFEA 1PU7A 1N3CA 1HU0A 4OFAA 4YOQA 3KTUA 4EA4A 3F0ZA 1LMZA 3FHFA 4UOBA 1MUNA 3CWTA 4E9EA 3IHOA 4YPHA 1NKUA 2NOZA 2JHNA 1MUYA 1NGNA 3S6IA 3FHGA 1N39A 3N5NX 2NOFA 3I0WA 1MUDA 1M3QA 2NOIA 2XHIA 2NOHA 1KG3A 3CWUA 1ORPA 4AIAA 4EW0A 1P59A 4EW4A 4HSBA 1M3HA 4B21A 3OGDA 3N0UA 2NOLA 1RRSA 4PIIA 4E9HA 4AI5A 1WEIA 2YG8A
chains in the Genus database with same CATH superfamily
4IKFA 3OH9A 1MPGA 2OFKA 5CHZA 1EBMA 3OYAA 3KNTA 4E9GA 2NOEA 1XQPA 3CWAA 1KEAA 1LWWA 3OYMA 2JHJA 1PVSA 4YPRA 3CWSA 1YQMA 3F10A 2W04A 3OYDA 2H56A 5FRMA 4OFHA 4BE0A 4DK9A 1DIZA 2JG6A 4UNFA 4B23A 1YQLA 1XQOA 4EVVA 3I0XA 1KG4A 3D4VA 2NOBA 2OFIA 1VRLA 1WEFA 3OYIA 2YG9A 3IH7A 1YQKA 2I5WA 3S3NA 3FSPA 3L2VA 3OYHA 1YQRA 4EA5A 3L2WA 1KO9A 3LCNA 1XG7A 1FN7A 4EJZA 1KQJA 1PU6A 4E7LA 3OY9A 1WEGA 3OYCA 2ABKA 4E7KA 3S3OA 3R2XC 3CVSA 1KG2A 4NZGA 4E7IA 3CVTA 3OS0A 4E9FA 1KG7A 5KN9A 3OYJA 5KN8A 5DPKA 4AI4A 4B24A 1ORNA 1LWVA 1N3AA 1RRQA 3NNQA 5FROA 4B22A 1P7MA 3OYNA 5AN4A 3OS2A 2W03A 3G0QA 1LWYA 1PU8A 1KG5A 4ZTJA 1KG6A 1U84A 4BDYA 4BE2A 3OS1A 3CW7A 4BE1A 3OYBA 3OH6A 4BACA 4EJYA 4OFEA 1PU7A 1N3CA 1HU0A 4ZTFA 2V75A 4OFAA 4YOQA 3KTUA 4EA4A 3F0ZA 5FRNA 1LMZA 3FHFA 4UOBA 1MUNA 3CWTA 3OYKA 4E9EA 3OYLA 3IHOA 3L2QA 4YPHA 3S3MA 3OYEA 1NKUA 2NOZA 4E7JA 3OYFA 2JHNA 3L2UA 1MUYA 1NGNA 4BDZA 3S6IA 3FHGA 1N39A 3N5NX 2NOFA 3I0WA 1MUDA 1M3QA 2NOIA 2XHIA 3L2RA 2NOHA 1KG3A 2JPSA 3CWUA 4E7HA 1ORPA 4AIAA 4EW0A 1P59A 4EW4A 4HSBA 1M3HA 4B21A 3OGDA 3N0UA 2NOLA 1RRSA 4PIIA 3OYGA 4E9HA 4AI5A 1WEIA 2YG8A 3VW4A
chains in the Genus database with same CATH topology
3OH9A 1MPGA 2OFKA 5CHZA 1EBMA 3KNTA 4E9GA 2NOEA 1XQPA 3CWAA 1KEAA 1LWWA 2JHJA 1PVSA 4YPRA 3CWSA 1YQMA 3F10A 2H56A 4OFHA 4DK9A 1DIZA 2JG6A 4UNFA 4B23A 1YQLA 1XQOA 4EVVA 3I0XA 1KG4A 3D4VA 2NOBA 2OFIA 1VRLA 1WEFA 1YQKA 2YG9A 3IH7A 2I5WA 3FSPA 1YQRA 4EA5A 1KO9A 1FN7A 1XG7A 4EJZA 1KQJA 1PU6A 1WEGA 2ABKA 3CVSA 1KG2A 3CVTA 4E9FA 1KG7A 5KN9A 5DPKA 5KN8A 4AI4A 4B24A 1ORNA 1LWVA 1N3AA 1RRQA 4B22A 1P7MA 5AN4A 3G0QA 1LWYA 1PU8A 1KG5A 1KG6A 3CW7A 3OH6A 4EJYA 4OFEA 1PU7A 1N3CA 1HU0A 4OFAA 4YOQA 3KTUA 4EA4A 3F0ZA 1LMZA 3FHFA 4UOBA 1MUNA 3CWTA 4E9EA 3IHOA 4YPHA 1NKUA 2NOZA 2JHNA 1MUYA 1NGNA 3S6IA 3FHGA 1N39A 3N5NX 2NOFA 3I0WA 1MUDA 1M3QA 2NOIA 2XHIA 2NOHA 1KG3A 3CWUA 1ORPA 4AIAA 4EW0A 1P59A 4EW4A 4HSBA 1M3HA 4B21A 3OGDA 3N0UA 2NOLA 1RRSA 4PIIA 4E9HA 4AI5A 1WEIA 2YG8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3OH9 A;  1MPG A;  2OFK A;  5CHZ A;  1EBM A;  3KNT A;  4E9G A;  2NOE A;  1XQP A;  3CWA A;  1KEA A;  1LWW A;  2JHJ A;  1PVS A;  4YPR A;  3CWS A;  1YQM A;  3F10 A;  2H56 A;  4OFH A;  4DK9 A;  1DIZ A;  2JG6 A;  4UNF A;  4B23 A;  1YQL A;  1XQO A;  4EVV A;  3I0X A;  1KG4 A;  3D4V A;  2NOB A;  2OFI A;  1VRL A;  1WEF A;  1YQK A;  2YG9 A;  3IH7 A;  2I5W A;  3FSP A;  1YQR A;  4EA5 A;  1KO9 A;  1FN7 A;  1XG7 A;  4EJZ A;  1KQJ A;  1PU6 A;  1WEG A;  2ABK A;  3CVS A;  1KG2 A;  3CVT A;  4E9F A;  1KG7 A;  5KN9 A;  5DPK A;  5KN8 A;  4AI4 A;  4B24 A;  1ORN A;  1LWV A;  1N3A A;  1RRQ A;  4B22 A;  1P7M A;  5AN4 A;  3G0Q A;  1LWY A;  1PU8 A;  1KG5 A;  1KG6 A;  3CW7 A;  3OH6 A;  4EJY A;  4OFE A;  1PU7 A;  1N3C A;  1HU0 A;  4OFA A;  4YOQ A;  3KTU A;  4EA4 A;  3F0Z A;  1LMZ A;  3FHF A;  4UOB A;  1MUN A;  3CWT A;  4E9E A;  3IHO A;  4YPH A;  1NKU A;  2NOZ A;  2JHN A;  1MUY A;  1NGN A;  3S6I A;  3FHG A;  1N39 A;  3N5N X;  2NOF A;  3I0W A;  1MUD A;  1M3Q A;  2NOI A;  2XHI A;  2NOH A;  1KG3 A;  3CWU A;  1ORP A;  4AIA A;  4EW0 A;  1P59 A;  4EW4 A;  4HSB A;  1M3H A;  4B21 A;  3OGD A;  3N0U A;  2NOL A;  1RRS A;  4PII A;  4E9H A;  4AI5 A;  1WEI A;  2YG8 A; 
#chains in the Genus database with same CATH topology
 4IKF A;  3OH9 A;  1MPG A;  2OFK A;  5CHZ A;  1EBM A;  3OYA A;  3KNT A;  4E9G A;  2NOE A;  1XQP A;  3CWA A;  1KEA A;  1LWW A;  3OYM A;  2JHJ A;  1PVS A;  4YPR A;  3CWS A;  1YQM A;  3F10 A;  2W04 A;  3OYD A;  2H56 A;  5FRM A;  4OFH A;  4BE0 A;  4DK9 A;  1DIZ A;  2JG6 A;  4UNF A;  4B23 A;  1YQL A;  1XQO A;  4EVV A;  3I0X A;  1KG4 A;  3D4V A;  2NOB A;  2OFI A;  1VRL A;  1WEF A;  3OYI A;  2YG9 A;  3IH7 A;  1YQK A;  2I5W A;  3S3N A;  3FSP A;  3L2V A;  3OYH A;  1YQR A;  4EA5 A;  3L2W A;  1KO9 A;  3LCN A;  1XG7 A;  1FN7 A;  4EJZ A;  1KQJ A;  1PU6 A;  4E7L A;  3OY9 A;  1WEG A;  3OYC A;  2ABK A;  4E7K A;  3S3O A;  3R2X C;  3CVS A;  1KG2 A;  4NZG A;  4E7I A;  3CVT A;  3OS0 A;  4E9F A;  1KG7 A;  5KN9 A;  3OYJ A;  5KN8 A;  5DPK A;  4AI4 A;  4B24 A;  1ORN A;  1LWV A;  1N3A A;  1RRQ A;  3NNQ A;  5FRO A;  4B22 A;  1P7M A;  3OYN A;  5AN4 A;  3OS2 A;  2W03 A;  3G0Q A;  1LWY A;  1PU8 A;  1KG5 A;  4ZTJ A;  1KG6 A;  1U84 A;  4BDY A;  4BE2 A;  3OS1 A;  3CW7 A;  4BE1 A;  3OYB A;  3OH6 A;  4BAC A;  4EJY A;  4OFE A;  1PU7 A;  1N3C A;  1HU0 A;  4ZTF A;  2V75 A;  4OFA A;  4YOQ A;  3KTU A;  4EA4 A;  3F0Z A;  5FRN A;  1LMZ A;  3FHF A;  4UOB A;  1MUN A;  3CWT A;  3OYK A;  4E9E A;  3OYL A;  3IHO A;  3L2Q A;  4YPH A;  3S3M A;  3OYE A;  1NKU A;  2NOZ A;  4E7J A;  3OYF A;  2JHN A;  3L2U A;  1MUY A;  1NGN A;  4BDZ A;  3S6I A;  3FHG A;  1N39 A;  3N5N X;  2NOF A;  3I0W A;  1MUD A;  1M3Q A;  2NOI A;  2XHI A;  3L2R A;  2NOH A;  1KG3 A;  2JPS A;  3CWU A;  4E7H A;  1ORP A;  4AIA A;  4EW0 A;  1P59 A;  4EW4 A;  4HSB A;  1M3H A;  4B21 A;  3OGD A;  3N0U A;  2NOL A;  1RRS A;  4PII A;  3OYG A;  4E9H A;  4AI5 A;  1WEI A;  2YG8 A;  3VW4 A; 
#chains in the Genus database with same CATH homology
 3OH9 A;  1MPG A;  2OFK A;  5CHZ A;  1EBM A;  3KNT A;  4E9G A;  2NOE A;  1XQP A;  3CWA A;  1KEA A;  1LWW A;  2JHJ A;  1PVS A;  4YPR A;  3CWS A;  1YQM A;  3F10 A;  2H56 A;  4OFH A;  4DK9 A;  1DIZ A;  2JG6 A;  4UNF A;  4B23 A;  1YQL A;  1XQO A;  4EVV A;  3I0X A;  1KG4 A;  3D4V A;  2NOB A;  2OFI A;  1VRL A;  1WEF A;  1YQK A;  2YG9 A;  3IH7 A;  2I5W A;  3FSP A;  1YQR A;  4EA5 A;  1KO9 A;  1FN7 A;  1XG7 A;  4EJZ A;  1KQJ A;  1PU6 A;  1WEG A;  2ABK A;  3CVS A;  1KG2 A;  3CVT A;  4E9F A;  1KG7 A;  5KN9 A;  5DPK A;  5KN8 A;  4AI4 A;  4B24 A;  1ORN A;  1LWV A;  1N3A A;  1RRQ A;  4B22 A;  1P7M A;  5AN4 A;  3G0Q A;  1LWY A;  1PU8 A;  1KG5 A;  1KG6 A;  3CW7 A;  3OH6 A;  4EJY A;  4OFE A;  1PU7 A;  1N3C A;  1HU0 A;  4OFA A;  4YOQ A;  3KTU A;  4EA4 A;  3F0Z A;  1LMZ A;  3FHF A;  4UOB A;  1MUN A;  3CWT A;  4E9E A;  3IHO A;  4YPH A;  1NKU A;  2NOZ A;  2JHN A;  1MUY A;  1NGN A;  3S6I A;  3FHG A;  1N39 A;  3N5N X;  2NOF A;  3I0W A;  1MUD A;  1M3Q A;  2NOI A;  2XHI A;  2NOH A;  1KG3 A;  3CWU A;  1ORP A;  4AIA A;  4EW0 A;  1P59 A;  4EW4 A;  4HSB A;  1M3H A;  4B21 A;  3OGD A;  3N0U A;  2NOL A;  1RRS A;  4PII A;  4E9H A;  4AI5 A;  1WEI A;  2YG8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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