4E9HA

Structure of glycosylase domain of mbd4 bound to 5hmu containing dna
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
137
structure length
137
Chain Sequence
WTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEAHKLNKYHDWLWENH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.
pubmed doi rcsb
molecule tags Hydrolase/dna
source organism Homo sapiens
molecule keywords Methyl-CpG-binding domain protein 4
total genus 49
structure length 137
sequence length 137
ec nomenclature ec 3.2.2.-:
pdb deposition date 2012-03-21
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4e9hA00
3F0ZA 3IH7A 1KG2A 2ABKA 2OFKA 2YG9A 3D4VA 1MUYA 5KN8A 2NOEA 2JHJA 5DPKA 4HSBA 3S6IA 3N0UA 3CVSA 3OH9A 3OH6A 1VRLA 1N3CA 4E9HA 2NOZA 1PU6A 2JHNA 4YPHA 3KNTA 1KQJA 1LWYA 1RRSA 1WEGA 1KG4A 1XQOA 2I5WA 3IHOA 5CHZA 2JG6A 1KG7A 1YQLA 2NOLA 1N39A 4AI5A 1N3AA 3FHFA 3CWSA 3N5NX 1MUNA 1KG5A 1LWWA 3CWTA 1DIZA 1NGNA 1LWVA 3FHGA 4B23A 1FN7A 4YOQA 1ORPA 1MPGA 4EW4A 2YG8A 3CWAA 1LMZA 4OFEA 4OFAA 1NKUA 4UNFA 1P59A 4E9FA 4EJZA 4B24A 1WEFA 5AN4A 2NOFA 3CW7A 3KTUA 4EVVA 1HU0A 3I0XA 3G0QA 4E9GA 1YQMA 1M3HA 1PU7A 1ORNA 2OFIA 1KG3A 4E9EA 3CVTA 2NOHA 2NOIA 1YQRA 4OFHA 3I0WA 1PU8A 5KN9A 1EBMA 4UOBA 1PVSA 4PIIA 4EW0A 4EA5A 3FSPA 4AI4A 3F10A 1KO9A 1P7MA 1RRQA 4DK9A 4B22A 1XG7A 1XQPA 1YQKA 1M3QA 1KG6A 4EJYA 2NOBA 1MUDA 4EA4A 1WEIA 4YPRA 2XHIA 1KEAA 4B21A 2H56A 4AIAA 3OGDA 3CWUA
chains in the Genus database with same CATH superfamily
3F0ZA 4E7JA 3IH7A 3OYBA 1KG2A 2ABKA 3OYFA 2OFKA 2YG9A 3D4VA 1MUYA 5KN8A 2NOEA 4BE2A 2JHJA 5DPKA 3L2UA 4HSBA 3S6IA 3N0UA 3CVSA 3OS0A 3OH9A 3OH6A 4BDZA 1VRLA 1N3CA 1U84A 4E9HA 2NOZA 1PU6A 2JHNA 3NNQA 4YPHA 3KNTA 1KQJA 1LWYA 1RRSA 3L2QA 1WEGA 1KG4A 1XQOA 2I5WA 3IHOA 5CHZA 2JG6A 3L2VA 4E7LA 1KG7A 1YQLA 3OYNA 4BDYA 2W04A 4IKFA 4E7KA 2NOLA 1N39A 4AI5A 1N3AA 3FHFA 3OYIA 3OYDA 3CWSA 3N5NX 1MUNA 1KG5A 3OYCA 3OYKA 3OYAA 1LWWA 3OYJA 3CWTA 4ZTFA 1DIZA 1NGNA 1LWVA 3FHGA 4B23A 1FN7A 4YOQA 4E7HA 1ORPA 1MPGA 4EW4A 2YG8A 3VW4A 3CWAA 1LMZA 4OFEA 4OFAA 1NKUA 4UNFA 1P59A 4E9FA 4NZGA 4EJZA 2JPSA 4B24A 1WEFA 5AN4A 3OYEA 2NOFA 3CW7A 3LCNA 3KTUA 4EVVA 1HU0A 3I0XA 3G0QA 4E9GA 3OS1A 1YQMA 1M3HA 1PU7A 1ORNA 3OYGA 5FRMA 3OYLA 5FRNA 2OFIA 4BE0A 1KG3A 3S3NA 4E9EA 3CVTA 2NOHA 2NOIA 1YQRA 3S3OA 4OFHA 3I0WA 4ZTJA 1PU8A 5KN9A 1EBMA 3OYMA 4UOBA 1PVSA 5FROA 4PIIA 3S3MA 4BACA 4EW0A 4EA5A 2V75A 3FSPA 4AI4A 3F10A 1KO9A 1P7MA 1RRQA 3R2XC 4DK9A 4B22A 1XG7A 1XQPA 1YQKA 1M3QA 3OYHA 1KG6A 4EJYA 2NOBA 1MUDA 4EA4A 3OY9A 1WEIA 4YPRA 2XHIA 3L2RA 4BE1A 1KEAA 3OS2A 4E7IA 2W03A 4B21A 2H56A 3L2WA 4AIAA 3OGDA 3CWUA
chains in the Genus database with same CATH topology
3F0ZA 3IH7A 1KG2A 2ABKA 2OFKA 2YG9A 3D4VA 1MUYA 5KN8A 2NOEA 2JHJA 5DPKA 4HSBA 3S6IA 3N0UA 3CVSA 3OH9A 3OH6A 1VRLA 1N3CA 4E9HA 2NOZA 1PU6A 2JHNA 4YPHA 3KNTA 1KQJA 1LWYA 1RRSA 1WEGA 1KG4A 1XQOA 2I5WA 3IHOA 5CHZA 2JG6A 1KG7A 1YQLA 2NOLA 1N39A 4AI5A 1N3AA 3FHFA 3CWSA 3N5NX 1MUNA 1KG5A 1LWWA 3CWTA 1DIZA 1NGNA 1LWVA 3FHGA 4B23A 1FN7A 4YOQA 1ORPA 1MPGA 4EW4A 2YG8A 3CWAA 1LMZA 4OFEA 4OFAA 1NKUA 4UNFA 1P59A 4E9FA 4EJZA 4B24A 1WEFA 5AN4A 2NOFA 3CW7A 3KTUA 4EVVA 1HU0A 3I0XA 3G0QA 4E9GA 1YQMA 1M3HA 1PU7A 1ORNA 2OFIA 1KG3A 4E9EA 3CVTA 2NOHA 2NOIA 1YQRA 4OFHA 3I0WA 1PU8A 5KN9A 1EBMA 4UOBA 1PVSA 4PIIA 4EW0A 4EA5A 3FSPA 4AI4A 3F10A 1KO9A 1P7MA 1RRQA 4DK9A 4B22A 1XG7A 1XQPA 1YQKA 1M3QA 1KG6A 4EJYA 2NOBA 1MUDA 4EA4A 1WEIA 4YPRA 2XHIA 1KEAA 4B21A 2H56A 4AIAA 3OGDA 3CWUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3F0Z A;  3IH7 A;  1KG2 A;  2ABK A;  2OFK A;  2YG9 A;  3D4V A;  1MUY A;  5KN8 A;  2NOE A;  2JHJ A;  5DPK A;  4HSB A;  3S6I A;  3N0U A;  3CVS A;  3OH9 A;  3OH6 A;  1VRL A;  1N3C A;  4E9H A;  2NOZ A;  1PU6 A;  2JHN A;  4YPH A;  3KNT A;  1KQJ A;  1LWY A;  1RRS A;  1WEG A;  1KG4 A;  1XQO A;  2I5W A;  3IHO A;  5CHZ A;  2JG6 A;  1KG7 A;  1YQL A;  2NOL A;  1N39 A;  4AI5 A;  1N3A A;  3FHF A;  3CWS A;  3N5N X;  1MUN A;  1KG5 A;  1LWW A;  3CWT A;  1DIZ A;  1NGN A;  1LWV A;  3FHG A;  4B23 A;  1FN7 A;  4YOQ A;  1ORP A;  1MPG A;  4EW4 A;  2YG8 A;  3CWA A;  1LMZ A;  4OFE A;  4OFA A;  1NKU A;  4UNF A;  1P59 A;  4E9F A;  4EJZ A;  4B24 A;  1WEF A;  5AN4 A;  2NOF A;  3CW7 A;  3KTU A;  4EVV A;  1HU0 A;  3I0X A;  3G0Q A;  4E9G A;  1YQM A;  1M3H A;  1PU7 A;  1ORN A;  2OFI A;  1KG3 A;  4E9E A;  3CVT A;  2NOH A;  2NOI A;  1YQR A;  4OFH A;  3I0W A;  1PU8 A;  5KN9 A;  1EBM A;  4UOB A;  1PVS A;  4PII A;  4EW0 A;  4EA5 A;  3FSP A;  4AI4 A;  3F10 A;  1KO9 A;  1P7M A;  1RRQ A;  4DK9 A;  4B22 A;  1XG7 A;  1XQP A;  1YQK A;  1M3Q A;  1KG6 A;  4EJY A;  2NOB A;  1MUD A;  4EA4 A;  1WEI A;  4YPR A;  2XHI A;  1KEA A;  4B21 A;  2H56 A;  4AIA A;  3OGD A;  3CWU A; 
#chains in the Genus database with same CATH topology
 3F0Z A;  4E7J A;  3IH7 A;  3OYB A;  1KG2 A;  2ABK A;  3OYF A;  2OFK A;  2YG9 A;  3D4V A;  1MUY A;  5KN8 A;  2NOE A;  4BE2 A;  2JHJ A;  5DPK A;  3L2U A;  4HSB A;  3S6I A;  3N0U A;  3CVS A;  3OS0 A;  3OH9 A;  3OH6 A;  4BDZ A;  1VRL A;  1N3C A;  1U84 A;  4E9H A;  2NOZ A;  1PU6 A;  2JHN A;  3NNQ A;  4YPH A;  3KNT A;  1KQJ A;  1LWY A;  1RRS A;  3L2Q A;  1WEG A;  1KG4 A;  1XQO A;  2I5W A;  3IHO A;  5CHZ A;  2JG6 A;  3L2V A;  4E7L A;  1KG7 A;  1YQL A;  3OYN A;  4BDY A;  2W04 A;  4IKF A;  4E7K A;  2NOL A;  1N39 A;  4AI5 A;  1N3A A;  3FHF A;  3OYI A;  3OYD A;  3CWS A;  3N5N X;  1MUN A;  1KG5 A;  3OYC A;  3OYK A;  3OYA A;  1LWW A;  3OYJ A;  3CWT A;  4ZTF A;  1DIZ A;  1NGN A;  1LWV A;  3FHG A;  4B23 A;  1FN7 A;  4YOQ A;  4E7H A;  1ORP A;  1MPG A;  4EW4 A;  2YG8 A;  3VW4 A;  3CWA A;  1LMZ A;  4OFE A;  4OFA A;  1NKU A;  4UNF A;  1P59 A;  4E9F A;  4NZG A;  4EJZ A;  2JPS A;  4B24 A;  1WEF A;  5AN4 A;  3OYE A;  2NOF A;  3CW7 A;  3LCN A;  3KTU A;  4EVV A;  1HU0 A;  3I0X A;  3G0Q A;  4E9G A;  3OS1 A;  1YQM A;  1M3H A;  1PU7 A;  1ORN A;  3OYG A;  5FRM A;  3OYL A;  5FRN A;  2OFI A;  4BE0 A;  1KG3 A;  3S3N A;  4E9E A;  3CVT A;  2NOH A;  2NOI A;  1YQR A;  3S3O A;  4OFH A;  3I0W A;  4ZTJ A;  1PU8 A;  5KN9 A;  1EBM A;  3OYM A;  4UOB A;  1PVS A;  5FRO A;  4PII A;  3S3M A;  4BAC A;  4EW0 A;  4EA5 A;  2V75 A;  3FSP A;  4AI4 A;  3F10 A;  1KO9 A;  1P7M A;  1RRQ A;  3R2X C;  4DK9 A;  4B22 A;  1XG7 A;  1XQP A;  1YQK A;  1M3Q A;  3OYH A;  1KG6 A;  4EJY A;  2NOB A;  1MUD A;  4EA4 A;  3OY9 A;  1WEI A;  4YPR A;  2XHI A;  3L2R A;  4BE1 A;  1KEA A;  3OS2 A;  4E7I A;  2W03 A;  4B21 A;  2H56 A;  3L2W A;  4AIA A;  3OGD A;  3CWU A; 
#chains in the Genus database with same CATH homology
 3F0Z A;  3IH7 A;  1KG2 A;  2ABK A;  2OFK A;  2YG9 A;  3D4V A;  1MUY A;  5KN8 A;  2NOE A;  2JHJ A;  5DPK A;  4HSB A;  3S6I A;  3N0U A;  3CVS A;  3OH9 A;  3OH6 A;  1VRL A;  1N3C A;  4E9H A;  2NOZ A;  1PU6 A;  2JHN A;  4YPH A;  3KNT A;  1KQJ A;  1LWY A;  1RRS A;  1WEG A;  1KG4 A;  1XQO A;  2I5W A;  3IHO A;  5CHZ A;  2JG6 A;  1KG7 A;  1YQL A;  2NOL A;  1N39 A;  4AI5 A;  1N3A A;  3FHF A;  3CWS A;  3N5N X;  1MUN A;  1KG5 A;  1LWW A;  3CWT A;  1DIZ A;  1NGN A;  1LWV A;  3FHG A;  4B23 A;  1FN7 A;  4YOQ A;  1ORP A;  1MPG A;  4EW4 A;  2YG8 A;  3CWA A;  1LMZ A;  4OFE A;  4OFA A;  1NKU A;  4UNF A;  1P59 A;  4E9F A;  4EJZ A;  4B24 A;  1WEF A;  5AN4 A;  2NOF A;  3CW7 A;  3KTU A;  4EVV A;  1HU0 A;  3I0X A;  3G0Q A;  4E9G A;  1YQM A;  1M3H A;  1PU7 A;  1ORN A;  2OFI A;  1KG3 A;  4E9E A;  3CVT A;  2NOH A;  2NOI A;  1YQR A;  4OFH A;  3I0W A;  1PU8 A;  5KN9 A;  1EBM A;  4UOB A;  1PVS A;  4PII A;  4EW0 A;  4EA5 A;  3FSP A;  4AI4 A;  3F10 A;  1KO9 A;  1P7M A;  1RRQ A;  4DK9 A;  4B22 A;  1XG7 A;  1XQP A;  1YQK A;  1M3Q A;  1KG6 A;  4EJY A;  2NOB A;  1MUD A;  4EA4 A;  1WEI A;  4YPR A;  2XHI A;  1KEA A;  4B21 A;  2H56 A;  4AIA A;  3OGD A;  3CWU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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