4EA4 | Genus

Total Genus 45

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	45
sequence length	137
structure length	137
Chain Sequence	WTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEAHKLNKYHDWLWENH

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Hydrolase/dna
source organism	Homo sapiens
publication title	Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA. pubmed doi rcsb
molecule keywords	Methyl-CpG-binding domain protein 4
total genus	45
structure length	137
sequence length	137
ec nomenclature	ec 3.2.2.-:
pdb deposition date	2012-03-22

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.340.30	Mainly Alpha	Orthogonal Bundle	Endonuclease III; domain 1	Hypothetical protein; domain 2	4ea4A00

1MPGA 1KG6A 1PU7A 3KTUA 1LWYA 1KG4A 1PVSA 4YOQA 5DPKA 4HSBA 1N39A 4EW0A 4EJZA 5AN4A 1XQOA 2NOIA 1P59A 4OFEA 1N3AA 1YQRA 1NKUA 3D4VA 1PU8A 1MUYA 2YG8A 3S6IA 3FHGA 3I0WA 2OFKA 3OH6A 1LWWA 2NOEA 1WEIA 3CWSA 2XHIA 3F0ZA 3I0XA 4EA5A 4E9GA 3OH9A 2NOBA 2I5WA 1YQLA 4EJYA 1YQMA 1KG2A 3IH7A 1FN7A 1XG7A 5CHZA 1YQKA 2YG9A 3FSPA 1EBMA 2ABKA 2OFIA 3CW7A 4E9HA 3KNTA 3CVSA 3N0UA 4B23A 2NOZA 3OGDA 4B22A 3CWUA 1HU0A 4YPHA 2JHNA 4B21A 1KEAA 1RRSA 3G0QA 1MUNA 1WEGA 1XQPA 3N5NX 4AI4A 3CWAA 1N3CA 2JHJA 1LWVA 5KN8A 4E9FA 1MUDA 1M3QA 4YPRA 4PIIA 1KG3A 4B24A 1PU6A 4EA4A 2NOHA 2NOLA 1KG7A 2H56A 4EVVA 1ORPA 1WEFA 4AI5A 2JG6A 3IHOA 1P7MA 1VRLA 3FHFA 1M3HA 1KG5A 4AIAA 1RRQA 3CWTA 3F10A 4UNFA 5KN9A 1NGNA 1LMZA 1KQJA 1KO9A 4UOBA 2NOFA 1ORNA 4OFAA 4EW4A 4DK9A 3CVTA 1DIZA 4E9EA 4OFHA
chains in the Genus database with same CATH superfamily

1MPGA 3VW4A 1KG6A 1PU7A 3KTUA 4BDYA 1LWYA 1KG4A 1PVSA 4YOQA 5DPKA 3OYMA 4HSBA 1N39A 4EW0A 4EJZA 5AN4A 4BACA 4E7IA 1XQOA 2NOIA 1P59A 4OFEA 1N3AA 3OYKA 3OYAA 3OYEA 1YQRA 1NKUA 3LCNA 3R2XC 3D4VA 1PU8A 1MUYA 2YG8A 3S3MA 3S6IA 3OS1A 3FHGA 3I0WA 2OFKA 3OH6A 1LWWA 2NOEA 1WEIA 3S3NA 3CWSA 2XHIA 3S3OA 3F0ZA 3I0XA 4EA5A 4E9GA 3OH9A 2NOBA 2I5WA 1YQLA 4EJYA 1YQMA 1KG2A 3IH7A 1FN7A 5FRNA 1XG7A 5CHZA 4BE1A 3OYNA 1YQKA 2YG9A 3FSPA 3OYLA 4IKFA 1EBMA 2ABKA 4E7HA 2OFIA 2W03A 3CW7A 4E9HA 3KNTA 3CVSA 3N0UA 4B23A 4BDZA 2NOZA 3OGDA 4B22A 3CWUA 3OY9A 1HU0A 4YPHA 2JHNA 2JPSA 4B21A 1KEAA 1RRSA 3G0QA 4ZTFA 4E7KA 1MUNA 1WEGA 1XQPA 3NNQA 3N5NX 3OYIA 2V75A 3L2WA 5FRMA 3OYDA 4AI4A 3CWAA 1N3CA 2JHJA 3OYGA 1LWVA 5KN8A 4E9FA 3OYHA 3OS0A 1MUDA 1M3QA 5FROA 4YPRA 4PIIA 1KG3A 4B24A 1PU6A 4EA4A 3OS2A 2NOHA 3L2UA 2NOLA 1KG7A 2W04A 2H56A 4EVVA 1ORPA 1WEFA 3L2QA 4E7JA 4AI5A 2JG6A 3IHOA 1P7MA 4E7LA 3FHFA 1VRLA 1M3HA 1KG5A 4AIAA 1RRQA 4BE2A 3CWTA 3OYFA 3F10A 4UNFA 5KN9A 1NGNA 1LMZA 1KQJA 1KO9A 3L2RA 4UOBA 2NOFA 3OYCA 3L2VA 3OYJA 1ORNA 4OFAA 4EW4A 4DK9A 3CVTA 1DIZA 1U84A 4E9EA 4ZTJA 4OFHA 4BE0A 4NZGA 3OYBA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 1MPG A;  1KG6 A;  1PU7 A;  3KTU A;  1LWY A;  1KG4 A;  1PVS A;  4YOQ A;  5DPK A;  4HSB A;  1N39 A;  4EW0 A;  4EJZ A;  5AN4 A;  1XQO A;  2NOI A;  1P59 A;  4OFE A;  1N3A A;  1YQR A;  1NKU A;  3D4V A;  1PU8 A;  1MUY A;  2YG8 A;  3S6I A;  3FHG A;  3I0W A;  2OFK A;  3OH6 A;  1LWW A;  2NOE A;  1WEI A;  3CWS A;  2XHI A;  3F0Z A;  3I0X A;  4EA5 A;  4E9G A;  3OH9 A;  2NOB A;  2I5W A;  1YQL A;  4EJY A;  1YQM A;  1KG2 A;  3IH7 A;  1FN7 A;  1XG7 A;  5CHZ A;  1YQK A;  2YG9 A;  3FSP A;  1EBM A;  2ABK A;  2OFI A;  3CW7 A;  4E9H A;  3KNT A;  3CVS A;  3N0U A;  4B23 A;  2NOZ A;  3OGD A;  4B22 A;  3CWU A;  1HU0 A;  4YPH A;  2JHN A;  4B21 A;  1KEA A;  1RRS A;  3G0Q A;  1MUN A;  1WEG A;  1XQP A;  3N5N X;  4AI4 A;  3CWA A;  1N3C A;  2JHJ A;  1LWV A;  5KN8 A;  4E9F A;  1MUD A;  1M3Q A;  4YPR A;  4PII A;  1KG3 A;  4B24 A;  1PU6 A;  4EA4 A;  2NOH A;  2NOL A;  1KG7 A;  2H56 A;  4EVV A;  1ORP A;  1WEF A;  4AI5 A;  2JG6 A;  3IHO A;  1P7M A;  1VRL A;  3FHF A;  1M3H A;  1KG5 A;  4AIA A;  1RRQ A;  3CWT A;  3F10 A;  4UNF A;  5KN9 A;  1NGN A;  1LMZ A;  1KQJ A;  1KO9 A;  4UOB A;  2NOF A;  1ORN A;  4OFA A;  4EW4 A;  4DK9 A;  3CVT A;  1DIZ A;  4E9E A;  4OFH A; 
#chains in the Genus database with same CATH topology
 1MPG A;  3VW4 A;  1KG6 A;  1PU7 A;  3KTU A;  4BDY A;  1LWY A;  1KG4 A;  1PVS A;  4YOQ A;  5DPK A;  3OYM A;  4HSB A;  1N39 A;  4EW0 A;  4EJZ A;  5AN4 A;  4BAC A;  4E7I A;  1XQO A;  2NOI A;  1P59 A;  4OFE A;  1N3A A;  3OYK A;  3OYA A;  3OYE A;  1YQR A;  1NKU A;  3LCN A;  3R2X C;  3D4V A;  1PU8 A;  1MUY A;  2YG8 A;  3S3M A;  3S6I A;  3OS1 A;  3FHG A;  3I0W A;  2OFK A;  3OH6 A;  1LWW A;  2NOE A;  1WEI A;  3S3N A;  3CWS A;  2XHI A;  3S3O A;  3F0Z A;  3I0X A;  4EA5 A;  4E9G A;  3OH9 A;  2NOB A;  2I5W A;  1YQL A;  4EJY A;  1YQM A;  1KG2 A;  3IH7 A;  1FN7 A;  5FRN A;  1XG7 A;  5CHZ A;  4BE1 A;  3OYN A;  1YQK A;  2YG9 A;  3FSP A;  3OYL A;  4IKF A;  1EBM A;  2ABK A;  4E7H A;  2OFI A;  2W03 A;  3CW7 A;  4E9H A;  3KNT A;  3CVS A;  3N0U A;  4B23 A;  4BDZ A;  2NOZ A;  3OGD A;  4B22 A;  3CWU A;  3OY9 A;  1HU0 A;  4YPH A;  2JHN A;  2JPS A;  4B21 A;  1KEA A;  1RRS A;  3G0Q A;  4ZTF A;  4E7K A;  1MUN A;  1WEG A;  1XQP A;  3NNQ A;  3N5N X;  3OYI A;  2V75 A;  3L2W A;  5FRM A;  3OYD A;  4AI4 A;  3CWA A;  1N3C A;  2JHJ A;  3OYG A;  1LWV A;  5KN8 A;  4E9F A;  3OYH A;  3OS0 A;  1MUD A;  1M3Q A;  5FRO A;  4YPR A;  4PII A;  1KG3 A;  4B24 A;  1PU6 A;  4EA4 A;  3OS2 A;  2NOH A;  3L2U A;  2NOL A;  1KG7 A;  2W04 A;  2H56 A;  4EVV A;  1ORP A;  1WEF A;  3L2Q A;  4E7J A;  4AI5 A;  2JG6 A;  3IHO A;  1P7M A;  4E7L A;  3FHF A;  1VRL A;  1M3H A;  1KG5 A;  4AIA A;  1RRQ A;  4BE2 A;  3CWT A;  3OYF A;  3F10 A;  4UNF A;  5KN9 A;  1NGN A;  1LMZ A;  1KQJ A;  1KO9 A;  3L2R A;  4UOB A;  2NOF A;  3OYC A;  3L2V A;  3OYJ A;  1ORN A;  4OFA A;  4EW4 A;  4DK9 A;  3CVT A;  1DIZ A;  1U84 A;  4E9E A;  4ZTJ A;  4OFH A;  4BE0 A;  4NZG A;  3OYB A; 
#chains in the Genus database with same CATH homology
 1MPG A;  1KG6 A;  1PU7 A;  3KTU A;  1LWY A;  1KG4 A;  1PVS A;  4YOQ A;  5DPK A;  4HSB A;  1N39 A;  4EW0 A;  4EJZ A;  5AN4 A;  1XQO A;  2NOI A;  1P59 A;  4OFE A;  1N3A A;  1YQR A;  1NKU A;  3D4V A;  1PU8 A;  1MUY A;  2YG8 A;  3S6I A;  3FHG A;  3I0W A;  2OFK A;  3OH6 A;  1LWW A;  2NOE A;  1WEI A;  3CWS A;  2XHI A;  3F0Z A;  3I0X A;  4EA5 A;  4E9G A;  3OH9 A;  2NOB A;  2I5W A;  1YQL A;  4EJY A;  1YQM A;  1KG2 A;  3IH7 A;  1FN7 A;  1XG7 A;  5CHZ A;  1YQK A;  2YG9 A;  3FSP A;  1EBM A;  2ABK A;  2OFI A;  3CW7 A;  4E9H A;  3KNT A;  3CVS A;  3N0U A;  4B23 A;  2NOZ A;  3OGD A;  4B22 A;  3CWU A;  1HU0 A;  4YPH A;  2JHN A;  4B21 A;  1KEA A;  1RRS A;  3G0Q A;  1MUN A;  1WEG A;  1XQP A;  3N5N X;  4AI4 A;  3CWA A;  1N3C A;  2JHJ A;  1LWV A;  5KN8 A;  4E9F A;  1MUD A;  1M3Q A;  4YPR A;  4PII A;  1KG3 A;  4B24 A;  1PU6 A;  4EA4 A;  2NOH A;  2NOL A;  1KG7 A;  2H56 A;  4EVV A;  1ORP A;  1WEF A;  4AI5 A;  2JG6 A;  3IHO A;  1P7M A;  1VRL A;  3FHF A;  1M3H A;  1KG5 A;  4AIA A;  1RRQ A;  3CWT A;  3F10 A;  4UNF A;  5KN9 A;  1NGN A;  1LMZ A;  1KQJ A;  1KO9 A;  4UOB A;  2NOF A;  1ORN A;  4OFA A;  4EW4 A;  4DK9 A;  3CVT A;  1DIZ A;  4E9E A;  4OFH A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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4EA4A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization